TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.132 | Formula: C15H8BrNO4
H donors: 0 H acceptors: 3 LogP: 3.7 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc2c(c1)c(=O)cc(o2)c1ccccc1[N+](=O)[O-]
InChi: 1S/C15H8BrNO4/c16-9-5-6-14-11(7-9)13(18)8-15(21-14)10-3-1-2-4-12(10)17(19)20/h1-8H
InChiKey: GXUSNZYZTBJMIT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	No references
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.1153	0.2296
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0122	0.259	0.5159
Brugia malayi	cytochrome P450	0.0014	0.0003	0.0006
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.056	0.1172
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0413	0.8107
Echinococcus granulosus	lysine specific demethylase 5A	0.0118	0.2477	0.634
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0038	0.056	0.1434
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0388	0.7805
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0107	0.0275
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0417	0.0872
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0107	0.2107
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.056	0.1434
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.1153	0.4451
Brugia malayi	jmjC domain containing protein	0.0118	0.2477	0.5179
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0107	0.0414
Brugia malayi	jmjC domain containing protein	0.0031	0.0409	0.0856
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0038	0.056	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0201	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0014	0.0003	0.0011
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.4783	1
Loa Loa (eye worm)	sugar transporter	0.0102	0.2094	0.4378
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0388	0.0707
Schistosoma mansoni	nAChR subunit	0.0017	0.0074	0.0189
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0388	0.0994
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.007	0.1383
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0404	0.0844
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0413	0.0752
Mycobacterium ulcerans	lipase LipD	0.0035	0.0497	0.1918
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0413	0.0752
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0031	0.0409	0.8033
Brugia malayi	jmjC domain containing protein	0.0031	0.0409	0.0856
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0003	0.0056
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0404	0.7919
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0031	0.0409	0.8033
Schistosoma mansoni	glucose transport protein	0.0102	0.2094	0.536
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0038	0.056	0.1434
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.056	0.1434
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0014	0.0003	0.0011
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0144	0.0368
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0017	0.0074	0.0155
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Echinococcus multilocularis	nAChR subunit	0.0038	0.056	0.1434
Onchocerca volvulus		0.0017	0.0074	0.0135
Schistosoma mansoni	hypothetical protein	0.0032	0.0417	0.1067
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.1153	0.1762
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0497	0.9751
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.056	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Brugia malayi	beta-lactamase	0.0035	0.0497	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.056	0.1434
Echinococcus granulosus	GPCR family 2	0.0032	0.0417	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Echinococcus multilocularis		0.0014	0.0003	0.0007
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0134	0.0244
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0497	0.099
Schistosoma mansoni	protein kinase	0.0031	0.0404	0.1033
Toxoplasma gondii	protein kinase, putative	0.0287	0.6542	1
Brugia malayi	Pre-SET motif family protein	0.0214	0.4783	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.2058	0.4302
Schistosoma mansoni	glucose transport protein	0.0102	0.2094	0.536
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0107	0.0275
Entamoeba histolytica	protein kinase, putative	0.0031	0.0404	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0388	0.0812
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0404	0.0735
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0497	0.1272
Schistosoma mansoni	cytochrome P450	0.0014	0.0003	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0413	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.1153	0.4451
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0155
Brugia malayi	Cation transporter family protein	0.0038	0.056	0.1172
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0038	0.056	0.1434
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0038	0.056	0.1172
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0074	0.0155
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0122	0.259	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0201	0.5182
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0393	0.1005
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0017	0.0074	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0497	0.099
Schistosoma mansoni	acetylcholine receptor-related	0.0017	0.0074	0.0189
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0497	0.0905
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0014	0.0003	0.0006
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0497	0.099
Onchocerca volvulus		0.0038	0.056	0.1021
Loa Loa (eye worm)	jmjC domain-containing protein	0.0031	0.0409	0.0856
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.1153	0.4451
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0393	0.06
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.056	0.1172
Entamoeba histolytica	protein kinase, putative	0.0031	0.0404	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0037	0.0544	0.2102
Leishmania major	glucose transporter, lmgt2	0.0031	0.0413	0.1595
Brugia malayi	Pre-SET motif family protein	0.0031	0.0393	0.0821
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0031	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0497	0.1039
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0014	0.0003	0.0011
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0278	0.5459
Onchocerca volvulus		0.0035	0.0497	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0404	0.0404
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0038	0.056	0.1172
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Onchocerca volvulus		0.002	0.0144	0.0262
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0017	0.0074	0.0189
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0357	0.0915
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0118	0.2477	0.634
Plasmodium vivax	hexose transporter	0.0102	0.2094	0.2094
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0107	0.2764
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Brugia malayi	Cation transporter family protein	0.0038	0.056	0.1172
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0413	0.8107
Loa Loa (eye worm)	jmjC domain-containing protein	0.0031	0.0409	0.0856
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0038	0.056	0.1172
Schistosoma mansoni	hypothetical protein	0.0032	0.0417	0.1067
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0003	0.0006
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0017	0.0074	0.0189
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0107	0.0275
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.051	0.051
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.2058	0.4302
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0409	0.0856
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.2058	0.4302
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.051	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0417	0.1067
Echinococcus multilocularis	jumonji domain containing 1A	0.0031	0.0409	0.1048
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0017	0.0074	0.0189
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0107	0.0214
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.056	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0038	0.056	0.1434
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0413	0.8107
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.056	0.1434
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.1153	0.2951
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0409	0.0856
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0497	0.1272
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0417	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0497	0.1039
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0014	0.0003	0.0006
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.056	0.1172
Brugia malayi	Cytochrome P450 family protein	0.0023	0.022	0.0461
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0003	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0393	0.0821
Leishmania major	hypothetical protein, conserved	0.0026	0.0278	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0404	0.0404
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0155
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2094	0.536
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0031	0.0409	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.056	0.1434
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0122	0.259	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0038	0.056	0.1172
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0413	0.8107
Toxoplasma gondii	ABC1 family protein	0.0035	0.0497	0.0759
Loa Loa (eye worm)	acetylcholine receptor protein	0.0017	0.0074	0.0155
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0107	0.0195
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0014	0.0003	0.0006
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0404	0.0404
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2094	0.3201
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.056	0.1172
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0014	0.0003	0.0011
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0404	0.0617
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0074	0.0189
Plasmodium vivax	JmjC domain containing protein	0.0031	0.0409	0.0409
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.051	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0014	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0107	0.0414
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0014	0.0003	0.0006
Plasmodium falciparum	hexose transporter	0.0102	0.2094	0.2094
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0003	0.0006
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0393	0.1005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0497	0.1039
Plasmodium falciparum	protein kinase 7	0.0287	0.6542	0.6542
Loa Loa (eye worm)	jmjC domain-containing protein	0.0118	0.2477	0.5179
Loa Loa (eye worm)	LGC-31 protein	0.0038	0.056	0.1172
Echinococcus multilocularis	JmjC domain containing protein 4	0.0031	0.0409	0.1048
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0017	0.0074	0.0155
Brugia malayi	jmjC domain containing protein	0.0031	0.0409	0.0856
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0014	0.0003	0.0004
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0118	0.2477	0.634
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0497	0.1272
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0014	0.0003	0.0006
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0107	0.0275
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.056	0.1434
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0014	0.0003	0.0011
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0038	0.056	0.1434
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0038	0.056	0.1172
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0122	0.259	0.6629
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.022	0.4326
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0497	0.0905
Onchocerca volvulus		0.0038	0.056	0.1021
Echinococcus granulosus	nAChR subunit	0.0038	0.056	0.1434
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.022	0.0461
Leishmania major	hypothetical protein, conserved	0.0031	0.0409	0.158
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Onchocerca volvulus		0.0035	0.0497	0.0905
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0014	0.0003	0.0011
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.056	0.1434
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0107	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.1298	0.2714
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0404	0.0404
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0014	0.0003	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0404	0.1033
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Leishmania major	DNA polymerase eta, putative	0.0019	0.0107	0.0414
Loa Loa (eye worm)	hypothetical protein	0.003	0.0388	0.0812
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0278	0.0278
Onchocerca volvulus		0.0035	0.0497	0.0905
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.056	0.1434
Schistosoma mansoni	jumonji domain containing protein	0.0031	0.0409	0.1048
Echinococcus multilocularis	lysine specific demethylase 5A	0.0118	0.2477	0.634
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0413	0.8107
Brugia malayi	beta-lactamase family protein	0.0035	0.0497	0.1039
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0038	0.056	0.1172
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0107	0.0414
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.056	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0409	0.0856
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0118	0.2477	0.634
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.056	0.1434
Onchocerca volvulus		0.0017	0.0074	0.0135
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0014	0.0003	0.0011
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.002	0.0144	0.0301
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.056	0.1172
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0038	0.056	0.1172
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0038	0.056	0.1172
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.056	0.1172
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.022	0.0461
Echinococcus granulosus	General substrate transporter	0.0087	0.1752	0.4483
Entamoeba histolytica	hypothetical protein	0.0023	0.0201	0.3171
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0003	0.0006
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0404	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Brugia malayi	Cam kinase protein 1	0.0031	0.0404	0.0844
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0014	0.0003	0.0006
Leishmania major	glucose transporter, lmgt3	0.0031	0.0413	0.1595
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0497	0.1272
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0201	0.0515
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0388	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0388	0.949
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0014	0.0003	0.0006
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.5021	1
Trichomonas vaginalis	esterase, putative	0.0035	0.0497	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0497	0.1039
Loa Loa (eye worm)	jmjC domain-containing protein	0.0031	0.0409	0.0856
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0278	0.0278
Schistosoma mansoni	hypothetical protein	0.0177	0.3907	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0017	0.0074	0.0155
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0014	0.0003	0.0011
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0014	0.0003	0.0011
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0201	0.0777
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0107	0.0224
Brugia malayi	jmjC domain containing protein	0.0118	0.2477	0.5179
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0497	0.099
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0497	0.1039
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0017	0.0074	0.0189
Echinococcus granulosus	phd:f box containing protein	0.0031	0.0409	0.1048
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0201	0.5
Echinococcus multilocularis	General substrate transporter	0.0087	0.1752	0.4483
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0107	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0278	0.0582
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0201	0.0515
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0014	0.0003	0.0011
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.022	0.0851
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Leishmania major	glucose transporter, lmgt1	0.0031	0.0413	0.1595
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0413	0.8107
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0497	0.1039
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0155
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0497	1
Onchocerca volvulus		0.0038	0.056	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0014	0.0003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0014	0.0003	0.0006
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0014	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.051	0.1967
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0393	0.1005
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0014	0.0003	0.0011
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0038	0.056	0.1172
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0201	0.0777
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0404	0.0404
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0201	0.0515
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0122	0.259	0.6629
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0404	0.0617
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0122	0.259	0.6629
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.022	0.0461
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.1153	0.4451
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0014	0.0003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0014	0.0003	0.0006
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0201	0.0308
Echinococcus granulosus	JmjC domain containing protein 4	0.0031	0.0409	0.1048
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0201	0.0515
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0164	0.3595	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0201	0.0201
Plasmodium vivax	SET domain protein, putative	0.0031	0.0393	0.0393
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0038	0.056	0.1434
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0003	0.0006
Onchocerca volvulus		0.002	0.0144	0.0262
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0417	0.1067
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.056	0.1434
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.1153	0.2951
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0164	0.3595	0.5495
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0014	0.0003	0.0006
Schistosoma mansoni	phd/f-box containing protein	0.0031	0.0409	0.1048
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0497	0.099
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0107	0.0224
Echinococcus multilocularis	nAChR subunit	0.002	0.0144	0.0368
Trypanosoma cruzi	hexose transporter	0.0031	0.0413	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0404	0.0844
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.1153	0.2951
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0122	0.259	0.5415
Echinococcus multilocularis	geminin	0.0177	0.3907	1
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0107	0.0275
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0413	0.1595
Schistosoma mansoni	nAChR subunit	0.0017	0.0074	0.0189
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0404	0.0404
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0107	0.0275
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0497	0.1918
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0107	0.2107
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0014	0.0003	0.0011
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0278	0.5459
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.011	0.2304	0.4817
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0417	0.1067
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0404	0.1033
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0201	0.0201
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0393	0.1005
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0388	0.0994
Leishmania major	cytochrome p450-like protein	0.0014	0.0003	0.0011
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0164	0.3595	0.3595
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0417	0.0872
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0017	0.0074	0.0155
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0038	0.056	0.1172
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0014	0.0003	0.0011
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0014	0.0003	0.0011
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0014	0.0003	0.0056
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0393	0.1005
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.056	0.1172
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0107	0.2107
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0497	0.1918
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0144	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0417	0.1067
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.056	0.1172
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.022	0.4326
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0074	0.0155
Onchocerca volvulus		0.0017	0.0074	0.0135
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0119	0.0238
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0014	0.0003	0.0006
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0144	0.0368
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0404	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2094	0.536
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.056	0.1434
Brugia malayi	Cation transporter family protein	0.0038	0.056	0.1172
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0201	0.395
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0014	0.0003	0.0006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0393	0.1005
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0119	0.0238
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.056	0.1434
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.056	0.1434
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0119	0.2357
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0038	0.056	0.1172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0301
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0201	0.0421
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0014	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.056	0.1172
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0155
Schistosoma mansoni	hypothetical protein	0.0102	0.2094	0.536
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0014	0.0003	0.0011
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0497	0.1918
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0038	0.056	0.1434
Leishmania major	protein kinase, putative	0.0031	0.0404	0.1558
Loa Loa (eye worm)	hypothetical protein	0.01	0.2058	0.4302
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0497	0.1039
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.056	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0413	0.0752
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0038	0.056	0.1434
Brugia malayi	hypothetical protein	0.0017	0.0058	0.0122
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0413	0.0752
Brugia malayi	hypothetical protein	0.0017	0.0074	0.0155
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0107	0.0195
Entamoeba histolytica	hypothetical protein	0.002	0.0144	0.1234
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0497	0.0905
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0031	0.0409	0.0626
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0404	0.0404
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.0074	0.0189
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0014	0.0003	0.0056
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0413	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0497	0.1039
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0278	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0404	0.0844
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0413	0.8107
Schistosoma mansoni	hypothetical protein	0.0068	0.1298	0.3323
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0497	0.099
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0	0.5
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.056	0.1434
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0497	0.099
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0017	0.0074	0.0155
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0031	0.0409	0.1048
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0107	0.2107
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0201	0.4017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0251	0.0525
Echinococcus granulosus	sodium channel protein	0.0037	0.0544	0.1393
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Onchocerca volvulus		0.0038	0.056	0.1021
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0388	0.0994
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0014	0.0003	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0413	0.0752
Schistosoma mansoni	jumonji domain containing protein	0.0118	0.2477	0.634
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0144	0.0301
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.056	0.1434
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0017	0.0074	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1298	0.2714
Leishmania major	cytochrome p450-like protein	0.0014	0.0003	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2094	0.3813
Loa Loa (eye worm)	hypothetical protein	0.003	0.0388	0.0812
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0014	0.0003	0.0006
Schistosoma mansoni	protein kinase	0.0031	0.0404	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0404	0.0844
Echinococcus granulosus	dna polymerase eta	0.0019	0.0107	0.0275
Echinococcus multilocularis	lysine specific demethylase 6a	0.0031	0.0409	0.1048
Onchocerca volvulus		0.0038	0.056	0.1021
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.056	0.1434
Echinococcus granulosus	jumonji domain containing 1A	0.0031	0.0409	0.1048
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0014	0.0003	0.0006
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0201	0.395
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0038	0.056	0.1172
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.051	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Onchocerca volvulus		0.0243	0.5492	1
Schistosoma mansoni	glucose transport protein	0.0102	0.2094	0.536
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0014	0.0003	0.0006
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0497	0.0905
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0014	0.0003	0.0006
Leishmania major	cytochrome p450-like protein	0.0023	0.022	0.0851
Onchocerca volvulus		0.0038	0.056	0.1021
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.056	0.1434
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0014	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0038	0.056	0.1434
Schistosoma mansoni	protein kinase	0.0031	0.0404	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0107	0.0224
Brugia malayi	jmjC domain containing protein	0.0031	0.0409	0.0856
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.5492	1
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.056	0.1172
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0497	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Echinococcus granulosus	geminin	0.0177	0.3907	1
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0031	0.0409	0.8033
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0497	0.099
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0201	0.0367
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0278	0.5459
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0278	0.0278
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0003	0.0056
Brugia malayi	hypothetical protein	0.0026	0.0278	0.0582
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0497	0.099
Schistosoma mansoni	phosphatidylserine receptor	0.0031	0.0409	0.1048
Schistosoma mansoni	hypothetical protein	0.0014	0.0003	0.0007
Echinococcus granulosus	nAChR subunit	0.002	0.0144	0.0368
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0107	0.0224
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0497	0.0905
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.051	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.1153	0.2951
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0201	0.0777
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0497	0.9751
Onchocerca volvulus	Putative nachr subunit	0.0038	0.056	0.1021
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0497	0.9751
Echinococcus multilocularis	sodium channel protein	0.0037	0.0544	0.1393
Brugia malayi	Sugar transporter family protein	0.0102	0.2094	0.4378
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.022	0.4326
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.056	0.1434
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Schistosoma mansoni	protein phosphatase 2C	0.0031	0.0409	0.1048
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0417	0.0872
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0497	0.0497
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0357	0.0915
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0037	0.0544	0.1393
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0497	0.1918
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0031	0.0409	0.1048
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0144	0.0301
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.002	0.0144	0.0368
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0107	0.2107
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0497	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.051	0.051
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0014	0.0003	0.0011
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0393	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Echinococcus multilocularis	phd:f box containing protein	0.0031	0.0409	0.1048
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0388	0.0812
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.056	0.1172
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0014	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0074	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0417	0.0872
Leishmania major	hypothetical protein, conserved	0.0035	0.0497	0.1918
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0122	0.259	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0031	0.0409	0.0626
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0404	0.0617
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0038	0.056	0.1434
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0107	0.0414
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0417	0.1067
Brugia malayi	beta-lactamase family protein	0.0035	0.0497	0.1039
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0388	0.0994
Trypanosoma brucei	unspecified product	0.0019	0.0107	0.2107
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.056	0.1172
Onchocerca volvulus		0.0031	0.0393	0.0715
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0366	0.0936
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0413	0.0752
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0107	0.2107
Echinococcus granulosus	lysine specific demethylase 6a	0.0031	0.0409	0.1048
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0413	0.8107
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0107	0.0275
Schistosoma mansoni	nAChR subunit	0.0038	0.056	0.1434
Brugia malayi	Cytochrome P450 family protein	0.0023	0.022	0.0461
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.051	0.1967
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0431	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0074	0.0155
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0404	0.0404
Schistosoma mansoni	hypothetical protein	0.0032	0.0417	0.1067
Loa Loa (eye worm)	GABA receptor subunit	0.002	0.0144	0.0301
Schistosoma mansoni	hypothetical protein	0.0177	0.3907	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0497	0.099
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0118	0.2477	0.634

Activities

Activity type	Activity value	Assay description	Source	Reference
-Log Ki (binding)	= 6.68	Binding affinity towards benzodiazepine site in GABAA receptor	ChEMBL.	11384234
Ki (binding)	= 6.68	Binding affinity towards benzodiazepine site in GABAA receptor	ChEMBL.	11384234
Ki (binding)	= 208 nM	Inhibition of [3H]-flunitrazepam [3H]-FNZ) binding to GABA-A Benzodiazepine receptor of synaptosomal membranes from rat cerebral cortex	ChEMBL.	No reference
Ki (binding)	= 208 nM	Inhibition of [3H]-flunitrazepam [3H]-FNZ) binding to GABA-A Benzodiazepine receptor of synaptosomal membranes from rat cerebral cortex	ChEMBL.	No reference
Ki (binding)	= 0.208 uM	Displacement of [3H]-flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane	ChEMBL.	No reference
Ki (binding)	= 0.208 uM	Displacement of [3H]-flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 84078