Detailed information for compound 848442

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.515 | Formula: C22H25N3O6S
  • H donors: 1 H acceptors: 5 LogP: 1.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)NC(=O)CN(S(=O)(=O)c1ccc2c(c1)C(C)(C)C(=O)N2C)C
  • InChi: 1S/C22H25N3O6S/c1-22(2)17-12-16(10-11-18(17)25(4)21(22)28)32(29,30)24(3)13-19(26)23-15-8-6-14(7-9-15)20(27)31-5/h6-12H,13H2,1-5H3,(H,23,26)
  • InChiKey: OGZPIZWZWCORAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0036 0.0019 0.0019
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0037
Echinococcus granulosus lamin 0.003 0.0014 0.0013
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0888 0.0844 0.2308
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0046 0.003 0.0256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0878 0.0834 0.8788
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0041 0.0024 0.0061
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0199 0.0177 0.1869
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.0357 1 1
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0102 0.0102
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0182 0.0161 0.016
Schistosoma mansoni lamin 0.003 0.0014 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0476 0.0445 0.4664
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0102 0.1023
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.004 0.0103
Loa Loa (eye worm) intermediate filament protein 0.003 0.0014 0.0106
Entamoeba histolytica casein kinase, putative 0.0153 0.0132 0.1346
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0005 0.0005
Echinococcus multilocularis 0.0182 0.0161 0.016
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0161 0.1271
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0281 0.0257 0.1815
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0014 0.0141
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0482 0.0451 0.4752
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0044
Loa Loa (eye worm) phosphatidylinositol 3 0.0257 0.0234 0.1849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0888 0.0844 0.889
Onchocerca volvulus 0.0262 0.0238 0.719
Schistosoma mansoni hypothetical protein 0.0107 0.0088 0.0623
Leishmania major phosphatidylinositol 4-kinase, putative 0.0182 0.0161 0.0435
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0016 0.0117
Brugia malayi Csnk2b protein 0.0041 0.0024 0.0254
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0102 0.0288
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0182 0.0161 0.1848
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0476 0.0445 0.0445
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0182 0.0161 0.0457
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0358 0.0331 0.0331
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0016 0.0117
Echinococcus multilocularis protein kinase shaggy 0.0057 0.004 0.0039
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0888 0.0844 0.5964
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0005 0.0055
Loa Loa (eye worm) calcium channel 0.0036 0.0019 0.0151
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0 0.0000000040169
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0051 0.0536
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Echinococcus multilocularis expressed protein 0.0416 0.0387 0.0387
Schistosoma mansoni intermediate filament proteins 0.003 0.0014 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8417
Schistosoma mansoni protein kinase 0.0153 0.0132 0.0934
Echinococcus multilocularis casein kinase ii subunit beta 0.0041 0.0024 0.0024
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1479 0.1415 0.1414
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0281 0.0257 0.0257
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0014 0.0106
Echinococcus granulosus single minded 2 0.004 0.0024 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0089 0.0881
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0102 0.1023
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0037
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.003 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.027 0.28
Echinococcus granulosus geminin 0.0187 0.0166 0.0166
Plasmodium vivax hypothetical protein 0.0182 0.0161 0.6246
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.0319 0.3324
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0042 0.0393
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0214 0.0191 0.1515
Brugia malayi Death domain containing protein 0.0016 0 0.0001
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0036 0.0019 0.0135
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.004 0.1385
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0005 0.0037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0182 0.0161 0.1645
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.004 0.0364
Loa Loa (eye worm) phosphatidylinositol 3 0.1321 0.1262 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0439 0.0409 0.4283
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0024 0.02
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0008 0.0023
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0257 0.0734
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0024 0.0023
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0005 0.0005
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.004 0.0039
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0005 0.0055
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0822 0.0779 0.9232
Brugia malayi Uncoordinated protein 44 0.0016 0 0.0001
Giardia lamblia Phosphatidylinositol 4-kinase 0.0182 0.0161 0.1742
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Onchocerca volvulus 0.0107 0.0088 0.2662
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Mycobacterium ulcerans putative regulatory protein 0.004 0.0024 0.1861
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0037
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0182 0.0161 0.6177
Brugia malayi Casein kinase II, alpha chain 0.0153 0.0132 0.1394
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0182 0.0161 0.1133
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0005 0.0037
Entamoeba histolytica hypothetical protein 0.0493 0.0461 0.4831
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0006 0.0007
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0888 0.0844 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.003 0.0079
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0191 0.0546
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0868 0.0824 0.9764
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0102 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0161 0.1645
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0868 0.0824 0.2254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.0539 0.566
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0102 0.1149
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0006 0.001
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0009 0.0062
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.003 0.0014 0.0096
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0078 0.0078
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0182 0.0161 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0051 0.0478
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0257 0.2998
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Echinococcus multilocularis survival motor neuron protein 1 0.0525 0.0492 0.0492
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0005 0.0005
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0051 0.014
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0019 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0016 0.0117
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Echinococcus multilocularis lamin dm0 0.003 0.0014 0.0013
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0009 0.0009
Trypanosoma brucei polo-like protein kinase 0.0214 0.0191 0.2216
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0129 0.091
Brugia malayi Pre-SET motif family protein 0.0033 0.0017 0.0174
Echinococcus multilocularis high voltage activated calcium channel beta 0.0097 0.0078 0.0078
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0019 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0016 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0888 0.0844 0.8896
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0997 0.0949 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0488 0.0457 0.4787
Mycobacterium leprae conserved hypothetical protein 0.0182 0.0161 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0493 0.0461 0.486
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0024 0.0064
Brugia malayi intracellular kinase 0.0057 0.004 0.0417
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0182 0.0161 0.6177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8416
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.003 0.0014 0.0143
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0102 0.1023
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0016 0.0632
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0036 0.0019 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.0834 0.0791 0.6266
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0182 0.0161 0.196
Brugia malayi hypothetical protein 0.004 0.0024 0.0246
Schistosoma mansoni hypothetical protein 0.0182 0.0161 0.1133
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0281 0.0257 0.2707
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0182 0.0161 0.196
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0439 0.0409 0.4283
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Loa Loa (eye worm) gastrulation defective protein 1 0.0145 0.0125 0.0992
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.024 0.1897
Toxoplasma gondii CMGC kinase, CK2 family 0.0153 0.0132 0.1616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Loa Loa (eye worm) hypothetical protein 0.0731 0.0692 0.5482
Toxoplasma gondii hypothetical protein 0.0022 0.0006 0.007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1479 0.1415 0.1414
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0755 0.0715 0.7522
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0099 0.0081 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.0859 0.0859
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0182 0.0161 0.0457
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0199 0.0177 0.1404
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0102 0.1023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0548 0.0514 0.6071
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0493 0.0461 0.5434
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.0161 0.1691
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0046 0.003 0.0256
Trichomonas vaginalis set domain proteins, putative 0.0262 0.0238 0.2465
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0078 0.0078
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0878 0.0834 0.5892
Brugia malayi Serotonin receptor 0.052 0.0488 0.5139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0161 0.1645
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0476 0.0445 0.0445
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0016 0.0632
Loa Loa (eye worm) hypothetical protein 0.0379 0.0351 0.2781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0868 0.0824 0.8679
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0281 0.0257 0.2667
Loa Loa (eye worm) hypothetical protein 0.0182 0.0161 0.1271
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0014 0.0089
Echinococcus multilocularis musashi 0.003 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0488 0.0457 0.4787
Brugia malayi 6-phosphofructokinase 0.0121 0.0102 0.1073
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0281 0.0257 0.3137
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0016 0.0117
Leishmania major phosphatidylinositol 3-kinase, putative 0.0281 0.0257 0.0699
Loa Loa (eye worm) phosphatidylinositol 3 0.0888 0.0844 0.6685
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0016 0.0117
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0005 0.0005
Brugia malayi FAT domain containing protein 0.0346 0.0319 0.336
Onchocerca volvulus 0.0182 0.0161 0.4846
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0068 0.0051 0.0355
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0358 0.0331 0.0331
Onchocerca volvulus 0.0057 0.004 0.1193
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0019 0.0019
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0016 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.018 0.1854
Loa Loa (eye worm) hypothetical protein 0.0316 0.029 0.2298
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0888 0.0844 0.2425
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0493 0.0461 0.4831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0868 0.0824 0.8679
Giardia lamblia GTOR 0.0888 0.0844 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.0779 0.8207
Entamoeba histolytica protein kinase rad3, putative 0.0476 0.0445 0.4664
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0493 0.0461 0.3258
Leishmania major phosphatidylinositol 3-kinase, putative 0.0822 0.0779 0.2132
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0182 0.0161 0.016
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0017 0.0016
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0005 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0161 0.1271
Echinococcus multilocularis casein kinase ii subunit alpha 0.0153 0.0132 0.0132
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0192
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Brugia malayi Protein kinase domain containing protein 0.0149 0.0129 0.1358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.0779 0.8207
Plasmodium falciparum casein kinase 2, alpha subunit 0.0153 0.0132 0.506
Trypanosoma brucei Casein kinase II 0.0153 0.0132 0.1512
Loa Loa (eye worm) hypothetical protein 0.0112 0.0093 0.0736
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0051 0.014
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0192
Brugia malayi SH2 domain containing protein 0.0379 0.0351 0.3701
Loa Loa (eye worm) Csnk2b protein 0.0041 0.0024 0.0191
Leishmania major phosphatidylinositol kinase, putative 0.0182 0.0161 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0037
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.004 0.0109
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0036 0.0019 0.0135
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0088 0.0929
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0997 0.0949 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8416
Brugia malayi Protein kinase domain containing protein 0.0358 0.0331 0.3489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0485 0.5084
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0009 0.007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0102 0.0274
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0182 0.0161 0.1645
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0019 0.0019
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0182 0.0161 0.1645
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0005 0.0055
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0051 0.0536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0041
Brugia malayi serine/threonine-protein kinase plk-2 0.0214 0.0191 0.2016
Echinococcus granulosus protein kinase shaggy 0.0057 0.004 0.0039
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0149 0.0129 0.102
Onchocerca volvulus 0.003 0.0014 0.0403
Schistosoma mansoni hypothetical protein 0.0057 0.004 0.0281
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0081 0.057
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0024 0.0937
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0997 0.0949 0.2727
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0281 0.0257 1
Trypanosoma cruzi casein kinase II, putative 0.0153 0.0132 0.0376
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.013
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.004 0.154
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0102 0.0806
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0016 0.0461
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0997 0.0949 1
Brugia malayi hypothetical protein 0.0182 0.0161 0.1692
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0024 0.02
Giardia lamblia Casein kinase II beta chain 0.0041 0.0024 0.0095
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0102 0.0719
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0051 0.005
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0024 0.02
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0017 0.0204
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.0161 0.1691
Echinococcus multilocularis expressed conserved protein 0.0091 0.0073 0.0072
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0008 0.0078
Leishmania major hypothetical protein, unknown function 0.0182 0.0161 0.0435
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0182 0.0161 0.1848
Onchocerca volvulus Serine\/threonine kinase homolog 0.0214 0.0191 0.5778
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0005 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0888 0.0844 1
Brugia malayi PAS domain containing protein 0.0054 0.0037 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.0116
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0024 0.0165
Toxoplasma gondii target of rapamycin (TOR), putative 0.0863 0.0819 1
Echinococcus multilocularis tumor protein p63 0.0377 0.0349 0.0349
Brugia malayi M-phase phosphoprotein, mpp8 0.0112 0.0093 0.0979
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0009 0.007
Onchocerca volvulus 0.003 0.0014 0.0403
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0878 0.0834 0.2396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.004 0.0313
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0019 0.0019
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0182 0.0161 0.1133
Brugia malayi phosphofructokinase 0.0121 0.0102 0.1073
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.0779 0.8207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0485 0.5084
Echinococcus granulosus high voltage activated calcium channel beta 0.0097 0.0078 0.0078
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0024 0.0023
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0439 0.0409 0.4816
Echinococcus granulosus expressed protein 0.0416 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0041
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0024 0.0725
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.004 0.0485
Schistosoma mansoni hypothetical protein 0.0187 0.0166 0.1171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0847 0.0804 0.847
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0005 0.0005
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0064 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0015 0.0015
Onchocerca volvulus 0.0055 0.0038 0.1143
Brugia malayi hypoxia-induced factor 1 0.0168 0.0147 0.1549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0005 0.0037
Plasmodium vivax SET domain protein, putative 0.0033 0.0017 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Loa Loa (eye worm) hypothetical protein 0.0476 0.0445 0.3527
Loa Loa (eye worm) hypothetical protein 0.0346 0.0319 0.2525
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0036 0.0019 0.0019
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0839 0.0796 0.8384
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0888 0.0844 0.889
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0006 0.0007
Plasmodium falciparum GAF domain-related protein, putative 0.0022 0.0006 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0017 0.0016
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0358 0.0331 0.2622
Onchocerca volvulus 0.0182 0.0161 0.4846
Plasmodium vivax hypothetical protein, conserved 0.0182 0.0161 0.6246
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0527 0.0495 0.5188
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0597 0.0562 0.6598
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0888 0.0844 0.2425
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0016 0.0461
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0 0.0000000040169
Schistosoma mansoni hypothetical protein 0.0346 0.0319 0.2253
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0009 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0214 0.0191 0.0191
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0182 0.0161 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0005 0.0005
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0024 0.0771
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0153 0.0132 0.5149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0868 0.0824 0.8679
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.0147 0.1164
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0214 0.0191 0.0519
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0731 0.0692 0.0692
Schistosoma mansoni hypothetical protein 0.0091 0.0073 0.0512
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0281 0.0257 0.2667
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0439 0.0409 0.4314
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0358 0.0331 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0815 0.0773 0.8136
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0009 0.0094
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0281 0.0257 0.1815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8417
Entamoeba histolytica protein kinase domain containing protein 0.0153 0.0132 0.1346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.0116
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0878 0.0834 0.0833
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0281 0.0257 0.2667
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.004 0.0024 0.0165
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.03
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trypanosoma cruzi hypothetical protein, conserved 0.3607 0.3473 1
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0005 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Toxoplasma gondii hypothetical protein 0.0022 0.0006 0.007
Onchocerca volvulus 0.004 0.0024 0.0705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0847 0.0804 0.847
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0182 0.0161 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0041
Loa Loa (eye worm) phosphatidylinositol kinase 0.0182 0.0161 0.1271
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0006 0.0043
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0102 0.0806
Echinococcus granulosus lamin dm0 0.003 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0041
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0523 0.0491 0.5145
Entamoeba histolytica protein kinase, putative 0.0057 0.004 0.0364
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0022 0.0006 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0089 0.0881
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.006 0.0042 0.0518
Schistosoma mansoni fkbp-rapamycin associated protein 0.0476 0.0445 0.3147
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0024 0.0725
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0024 0.0064
Echinococcus multilocularis lamin 0.003 0.0014 0.0013
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0192
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0281 0.0257 0.2667
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0106
Loa Loa (eye worm) hypothetical protein 0.0112 0.0093 0.0735
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0099 0.0081 0.0081
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0005 0.0005
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0358 0.0331 0.2622
Loa Loa (eye worm) hypothetical protein 0.0527 0.0495 0.3918
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0161 0.1271
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0476 0.0445 0.1277
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0161 0.1271
Toxoplasma gondii GAF domain-containing protein 0.0022 0.0006 0.007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0439 0.0409 0.4283
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0755 0.0715 0.7522
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0191 0.0546
Leishmania major cytochrome p450-like protein 0.0022 0.0006 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0888 0.0844 0.889
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0102 0.1023
Brugia malayi follicle stimulating hormone receptor 0.0263 0.024 0.2524
Loa Loa (eye worm) hypothetical protein 0.0036 0.0019 0.0151
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0102 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0997 0.0949 0.2727
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0006 0.0216
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0003 0.0018
Brugia malayi Pre-SET motif family protein 0.023 0.0207 0.2183
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0016 0.02
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0492 0.0461 0.3256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.0779 0.8207
Brugia malayi intermediate filament protein 0.003 0.0014 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0834 0.0791 0.833
Giardia lamblia Kinase, CMGC CK2 0.0153 0.0132 0.1402
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0102 0.0102
Brugia malayi hypothetical protein 0.0525 0.0492 0.519
Echinococcus granulosus intermediate filament protein 0.003 0.0014 0.0013
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0878 0.0834 0.2396
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0878 0.0834 0.0833
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0191 0.1351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.0161 0.1691
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0024 0.0771
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0005 0.0005
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0257 0.0734
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0888 0.0844 0.2308
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0024 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0017 0.0131
Loa Loa (eye worm) hypothetical protein 0.0311 0.0285 0.2259
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0346 0.0319 0.0319
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0051 0.014
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0257 0.0234 0.0667
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.003 0.0014 0.0014
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0888 0.0844 0.0844
Giardia lamblia Hypothetical protein 0.0182 0.0161 0.1742
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0006 0.0043
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0834 0.0791 0.2163
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0016 0.02
Giardia lamblia Kinase, CMGC GSK 0.0057 0.004 0.0282
Entamoeba histolytica hypothetical protein 0.0182 0.0161 0.1645
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.004 0.0364
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0198 0.0176 0.0502
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0182 0.0161 0.6246
Brugia malayi 6-phosphofructokinase 0.0121 0.0102 0.1073
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0182 0.0161 0.1133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0734 0.0695 0.7322
Entamoeba histolytica hypothetical protein 0.0182 0.0161 0.1645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0863 0.0819 0.8626
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0008 0.0023
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0051 0.0478
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0005 0.0037
Loa Loa (eye worm) hypothetical protein 0.0182 0.0161 0.1272
Brugia malayi Cytochrome P450 family protein 0.0022 0.0006 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0522 0.049 0.5137
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0005 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0042 0.0393
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0005 0.0055
Schistosoma mansoni lamin 0.003 0.0014 0.0094
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0223 0.02 0.232
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0016 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0006 0.0043
Onchocerca volvulus 0.0112 0.0093 0.2804
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0192
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0182 0.0161 0.1645
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0888 0.0844 0.889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0868 0.0824 0.8679
Echinococcus granulosus serine protein kinase ATM 0.0493 0.0461 0.0461
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0439 0.0409 0.4283
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0161 1
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0041 0.0024 0.0222
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0182 0.0161 0.6246
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0036 0.0019 0.0202
Echinococcus multilocularis cyclin dependent kinase 19 0.0149 0.0129 0.0129
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.049 0.0458 0.4802
Echinococcus granulosus survival motor neuron protein 1 0.0525 0.0492 0.0492
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0051 0.005
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0281 0.0257 0.2667
Leishmania major phosphatidylinositol kinase related protein, putative 0.0198 0.0176 0.0478
Trypanosoma cruzi target of rapamycin kinase 3 0.0868 0.0824 0.2368
Echinococcus multilocularis serine protein kinase ATM 0.0493 0.0461 0.0461
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0016 0.0117
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0038 0.0267
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0108
Brugia malayi Protein kinase domain containing protein 0.002 0.0004 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.004 0.0364
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0294 0.027 0.28
Entamoeba histolytica serine/threonine protein kinase, putative 0.0214 0.0191 0.1972
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1479 0.1415 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0358 0.0331 0.3489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8417
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0525 0.0492 0.39
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0097 0.0078 0.0551
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0014 0.0143
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0005 0.0037
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0041 0.0024 0.0296
Giardia lamblia Kinase, CMGC GSK 0.0057 0.004 0.0282
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0102 0.1023
Leishmania major casein kinase II, putative 0.0153 0.0132 0.0357
Echinococcus multilocularis geminin 0.0187 0.0166 0.0166
Brugia malayi hypothetical protein 0.0021 0.0005 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.0485 0.5084
Schistosoma mansoni kinase 0.011 0.0091 0.0643
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0014 0.0089
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0834 0.0791 0.937
Echinococcus granulosus casein kinase ii subunit alpha 0.0153 0.0132 0.0132
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trypanosoma brucei protein kinase, putative 0.0057 0.004 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0868 0.0824 0.8679
Brugia malayi Cytochrome P450 family protein 0.0022 0.0006 0.0057
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.004 0.0039
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0051 0.0478
Echinococcus granulosus tumor protein p63 0.0377 0.0349 0.0349
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0005 0.0041
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0053 0.0036 0.0285
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Schistosoma mansoni voltage-gated cation channel 0.0036 0.0019 0.0135
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0037 0.0261
Schistosoma mansoni ankyrin 23/unc44 0.0016 0 0.000000028401
Leishmania major hypothetical protein, conserved 0.3789 0.3649 1
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0153 0.0132 0.1047
Brugia malayi hypothetical protein 0.0021 0.0005 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0311 0.0285 0.0816
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0007 0.0053
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.004 0.0313
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0346 0.0319 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.0799 0.8417
Brugia malayi Cytochrome P450 family protein 0.0033 0.0017 0.0175
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0041
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0281 0.0257 0.0257
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0182 0.0161 0.016
Onchocerca volvulus 0.0046 0.0029 0.0865
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0281 0.0257 0.0257
Brugia malayi hypothetical protein 0.0112 0.0093 0.098
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0102 0.6215
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0102 0.1023
Echinococcus granulosus cyclin dependent kinase 19 0.0149 0.0129 0.0129
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0182 0.0161 0.6246
Schistosoma mansoni survival motor neuron protein 0.0107 0.0088 0.0623
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.004 0.0364
Onchocerca volvulus 0.0112 0.0093 0.2804
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0014 0.0089
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0339 0.0313 0.3584
Echinococcus granulosus casein kinase ii subunit beta 0.0041 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0029 0.0202
Schistosoma mansoni casein kinase II beta subunit 0.0041 0.0024 0.017
Toxoplasma gondii FATC domain-containing protein 0.0493 0.0461 0.563
Schistosoma mansoni hypothetical protein 0.0187 0.0166 0.1171
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0042 0.0393
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0132 0.1346
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0493 0.0461 0.1323
Brugia malayi PXA domain containing protein 0.0023 0.0007 0.0071
Giardia lamblia Kinase, PLK 0.0214 0.0191 0.2115
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0731 0.0692 0.0692
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0214 0.0191 0.0191
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0006 0.001
Entamoeba histolytica hypothetical protein 0.0839 0.0796 0.8384
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.0207 0.164
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0024 0.02
Plasmodium vivax unspecified product 0.0153 0.0132 0.5149
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0281 0.0257 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0476 0.0445 0.4693
Echinococcus granulosus expressed conserved protein 0.0091 0.0073 0.0072
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0257 0.0699
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0439 0.0409 0.1173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.0116
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0997 0.0949 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0005 0.0041
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0102 0.0719
Loa Loa (eye worm) RecQ helicase 0.0024 0.0008 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.051 0.5347
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0024 0.0937
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0081 0.057
Schistosoma mansoni single-minded 0.0054 0.0037 0.0261
Brugia malayi PXA domain containing protein 0.0023 0.0007 0.0071
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0888 0.0844 0.0844
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0182 0.0161 0.196
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0034
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0191 0.1972
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.004 0.0279
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0102 0.6215
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0997 0.0949 1
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0016 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.0331 0.2339
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0281 0.0257 0.3137
Echinococcus granulosus bloom syndrome protein 0.0024 0.0008 0.0007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0527 0.0495 0.604
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0102 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0281 0.0257 0.0257
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0019 0.0019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0888 0.0844 0.889
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0005 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0009 0.0062
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0182 0.0161 0.016
Toxoplasma gondii ck2 beta subunit 0.0041 0.0024 0.0296
Brugia malayi bHLH-PAS transcription factor 0.004 0.0024 0.0246
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0281 0.0257 0.2034
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0051 0.0478

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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