Detailed information for compound 86163

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 836.887 | Formula: C40H70BrNO12
  • H donors: 4 H acceptors: 5 LogP: 4.06 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C#CC[N+](C1CC(C)OC(C1O)O[C@@H]1C(C)C(OC2OC(C)C(C(C2)(C)OC)O)C(C)C(=O)OC([C@@]([C@@H]([C@H](C2O[C@@]1(C)C[C@H]2C)C)O)(C)O)CC)(C)C.[Br-]
  • InChi: 1S/C40H70NO12.BrH/c1-15-17-41(12,13)27-18-22(4)48-37(30(27)42)52-35-24(6)32(51-29-20-38(9,47-14)34(44)26(8)49-29)25(7)36(45)50-28(16-2)40(11,46)33(43)23(5)31-21(3)19-39(35,10)53-31;/h1,21-35,37,42-44,46H,16-20H2,2-14H3;1H/q+1;/p-1/t21-,22?,23+,24?,25?,26?,27?,28?,29?,30?,31?,32?,33-,34?,35-,37?,38?,39+,40-;/m1./s1
  • InChiKey: SWWGTIZLXJPPLM-ZBJJUFLDSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0018 0.0016 0.0039
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0361 0.099
Loa Loa (eye worm) hypothetical protein 0.0079 0.0652 0.0637
Onchocerca volvulus 0.003 0.0141 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0517 0.3183
Schistosoma mansoni protein kinase 0.0127 0.1152 0.3164
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0178 0.0463
Loa Loa (eye worm) glutathione reductase 0.0051 0.0359 0.0343
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0652 0.1259
Brugia malayi PXA domain containing protein 0.0031 0.0148 0.0139
Trypanosoma cruzi cdc2-related kinase 3 0.0141 0.1299 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.0148 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1152 0.2152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0361 0.0393
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.001 0.0075
Trichomonas vaginalis esterase, putative 0.0079 0.0652 0.1209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0178 0.137
Brugia malayi mbt repeat family protein 0.0051 0.0361 0.0351
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.001 0.0075
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0031 0.0148 0.0132
Loa Loa (eye worm) jmjC domain-containing protein 0.0129 0.1171 0.1157
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0178 0.1056
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0874 0.8936 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0333 0.0609
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0016 0.0123
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0359 0.0684
Loa Loa (eye worm) hypothetical protein 0.0031 0.0149 0.0133
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0031 0.0148 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0182 0.05
Echinococcus granulosus Regulator of G protein signaling 20 0.0031 0.0148 0.0381
Entamoeba histolytica cyclin, putative 0.0076 0.0617 0.4687
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0178 0.0189
Echinococcus granulosus peptidase Clp S14 family 0.0112 0.0991 0.2701
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.2977 0.8173
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0034 0.0182 0.0166
Schistosoma mansoni regulator of G protein signaling 0.0031 0.0148 0.0407
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1488 0.1657
Brugia malayi hypothetical protein 0.0018 0.0016 0.0006
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0141 0.1299 0.8088
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0652 0.5017
Echinococcus multilocularis regulator of G protein signaling 3 0.0031 0.0148 0.0155
Echinococcus granulosus cyclins 0.0018 0.0016 0.0017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0112 0.0991 0.1924
Echinococcus granulosus cyclin A3 4 0.0018 0.0016 0.0017
Echinococcus granulosus phd:f box containing protein 0.0034 0.0178 0.0463
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0652 0.1209
Echinococcus granulosus zinc finger protein 0.0025 0.0089 0.0219
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0435 0.0426
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0127 0.1152 0.8857
Echinococcus granulosus geminin 0.0366 0.3642 1
Entamoeba histolytica hypothetical protein 0.004 0.0237 0.1723
Echinococcus multilocularis aurora kinase A 0.0127 0.1152 0.128
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0141 0.1299 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0178 0.137
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0018 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0132
Echinococcus multilocularis zinc finger protein 0.0025 0.0089 0.0089
Brugia malayi A-kinase anchor protein 10, precursor 0.0031 0.0148 0.0139
Trichomonas vaginalis cyclins, putative 0.0102 0.0888 0.1655
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.1299 0.2428
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.002 0.0055
Brugia malayi mbt repeat family protein 0.0051 0.0361 0.0351
Brugia malayi Thioredoxin reductase 0.0051 0.0359 0.0349
Brugia malayi cell division control protein 2 homolog 0.0141 0.1299 0.1291
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0031 0.0148 0.0261
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0085 0.0713 0.0787
Trichomonas vaginalis cyclin B, putative 0.0102 0.0888 0.1655
Trypanosoma cruzi mitotic cyclin, putative 0.0018 0.0016 0.0123
Giardia lamblia G2/mitotic-specific cyclin B 0.0102 0.0888 0.6814
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0148 0.0261
Schistosoma mansoni lamin 0.003 0.0141 0.0388
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0361 0.0393
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0044
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Plasmodium falciparum cyclin 0.0076 0.0617 0.3811
Echinococcus granulosus cyclin B3 1 0.0076 0.0617 0.1673
Echinococcus granulosus cyclin dependent kinase 5 0.0141 0.1299 0.355
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.0148 0.0381
Echinococcus granulosus axis inhibition protein axin 0.0031 0.0148 0.0381
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0652 0.5017
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0302 0.2977 0.2965
Echinococcus multilocularis geminin 0.0366 0.3642 0.4069
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0127 0.1152 0.128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0652 0.4028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0713 0.1957
Echinococcus multilocularis lysine specific demethylase 5A 0.0127 0.115 0.1277
Onchocerca volvulus 0.0066 0.0517 0.0502
Schistosoma mansoni peptidase Clp (S14 family) 0.0171 0.1604 0.4404
Schistosoma mansoni axis inhibition protein axin 0.0031 0.0148 0.0407
Leishmania major trypanothione reductase 0.0051 0.0359 0.276
Schistosoma mansoni hypothetical protein 0.0312 0.3083 0.8465
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0076 0.0617 0.1673
Schistosoma mansoni jumonji domain containing protein 0.0127 0.115 0.3157
Brugia malayi regulator of G-protein signaling egl-10 0.0031 0.0148 0.0139
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0016 0.0012
Loa Loa (eye worm) cyclin domain-containing protein 0.0782 0.7982 0.7979
Schistosoma mansoni cyclin d 0.0018 0.0016 0.0044
Brugia malayi glutathione reductase 0.0051 0.0359 0.0349
Trypanosoma brucei cyclin 9 0.0018 0.0016 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0237 0.0651
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0168
Echinococcus granulosus cyclin b3 0.0076 0.0617 0.1673
Echinococcus multilocularis lamin dm0 0.003 0.0141 0.0147
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0087 0.0146
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0178 0.0489
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1488 0.148
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0652 0.1209
Toxoplasma gondii ABC1 family protein 0.0079 0.0652 0.4028
Entamoeba histolytica protein kinase, putative 0.0127 0.1152 0.8857
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0141 0.1299 0.1285
Schistosoma mansoni hypothetical protein 0.0052 0.0367 0.1007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0132
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0031 0.0148 0.0381
Schistosoma mansoni importin beta-1 0.0031 0.0149 0.0408
Onchocerca volvulus Huntingtin homolog 0.0132 0.1201 0.1187
Brugia malayi Protein kinase domain containing protein 0.0141 0.1299 0.1291
Loa Loa (eye worm) hypothetical protein 0.0255 0.2482 0.247
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0178 0.1056
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1937 0.2159
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0617 0.1144
Schistosoma mansoni regulator of G protein signaling 0.0031 0.0148 0.0407
Onchocerca volvulus 0.0079 0.0652 0.0637
Schistosoma mansoni lamin 0.003 0.0141 0.0388
Trypanosoma brucei aurora B kinase 0.0127 0.1152 0.8871
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0271 0.2653 0.2961
Schistosoma mansoni axis inhibition protein axin 0.0031 0.0148 0.0407
Leishmania major protein kinase, putative 0.0127 0.1152 0.8871
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0652 0.0643
Schistosoma mansoni cyclin B 0.0102 0.0888 0.2439
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0141 0.1299 0.1285
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0141 0.1299 0.355
Plasmodium vivax cyclin homologue, putative 0.0018 0.0016 0.0039
Trichomonas vaginalis cyclin A, putative 0.0018 0.0016 0.0012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0102 0.0888 0.0879
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0359 0.0961
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1043 0.5187
Echinococcus multilocularis expressed protein 0.0031 0.0148 0.0155
Loa Loa (eye worm) hypothetical protein 0.0079 0.0652 0.0637
Mycobacterium leprae Probable lipase LipE 0.0079 0.0652 0.1836
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0652 0.4028
Echinococcus granulosus snurportin 1 0.0332 0.3283 0.9013
Trypanosoma cruzi cdc2-related kinase 1 0.0141 0.1299 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0016 0.0006
Onchocerca volvulus 0.0051 0.0361 0.0345
Schistosoma mansoni z-protein (S1r protein) 0.0031 0.0148 0.0407
Entamoeba histolytica hypothetical protein 0.0031 0.0148 0.103
Loa Loa (eye worm) AUR protein kinase 0.0127 0.1152 0.1138
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0125
Schistosoma mansoni hypothetical protein 0.004 0.0237 0.0651
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.1178 0.2292
Mycobacterium ulcerans beta-lactamase 0.0079 0.0652 0.4028
Schistosoma mansoni Cyclin fold protein 0.0018 0.0016 0.0044
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.001 0.0027
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0112 0.0991 0.4744
Echinococcus granulosus cyclin dependent kinase 1 0.0141 0.1299 0.355
Leishmania major mitotic cyclin, putative 0.0018 0.0016 0.0123
Brugia malayi Cyclin, N-terminal domain containing protein 0.0102 0.0888 0.0879
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.001 0.0075
Mycobacterium tuberculosis Conserved protein 0.0079 0.0652 0.1259
Echinococcus granulosus beta-adrenergic receptor kinase 0.0302 0.2977 0.8168
Echinococcus multilocularis cyclin y 0.0018 0.0016 0.0007
Trichomonas vaginalis cyclin B3, putative 0.0076 0.0617 0.1144
Plasmodium falciparum protein kinase 5 0.0141 0.1299 0.8088
Schistosoma mansoni cyclin G 0.0018 0.0016 0.0044
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Plasmodium falciparum cyclin 1 0.0018 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0162
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0018 0.0016 0.0017
Brugia malayi Pre-SET motif family protein 0.0463 0.4653 0.4647
Trypanosoma brucei cyclin 3 0.0018 0.0016 0.0123
Echinococcus granulosus lysine specific demethylase 5A 0.0129 0.1171 0.3199
Entamoeba histolytica protein kinase domain containing protein 0.0127 0.1152 0.8857
Plasmodium falciparum glutathione reductase 0.0051 0.0359 0.2188
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0438 0.2685
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0127 0.1152 0.3146
Echinococcus multilocularis cyclin dependent kinase 1 0.0141 0.1299 0.1445
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0178 0.0189
Schistosoma mansoni hypothetical protein 0.0332 0.3283 0.9015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Brugia malayi beta-lactamase 0.0079 0.0652 0.0643
Loa Loa (eye worm) hypothetical protein 0.0102 0.0888 0.0874
Trypanosoma brucei mitotic cyclin 0.0018 0.0016 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0148 0.0261
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0171 0.1604 1
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.1299 0.2428
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.1178 0.2292
Trichomonas vaginalis cyclins, putative 0.0102 0.0888 0.1655
Giardia lamblia Hypothetical protein 0.0076 0.0617 0.4712
Trypanosoma brucei cdc2-related kinase 1 0.0141 0.1299 1
Toxoplasma gondii aurora kinase 0.0127 0.1152 0.7168
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0652 0.1259
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.002 0.0055
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0435 0.0476
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0031 0.0148 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0507 0.5109 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0148 0.0261
Schistosoma mansoni hypothetical protein 0.0366 0.3642 1
Brugia malayi hypothetical protein 0.0132 0.1201 0.1193
Trypanosoma brucei cdc2-related kinase 3 0.0141 0.1299 1
Mycobacterium ulcerans hypothetical protein 0.0079 0.0652 0.4028
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.001 0.0075
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0016 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1152 0.2152
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0149 0.1144
Entamoeba histolytica hypothetical protein 0.0031 0.0148 0.103
Giardia lamblia Kinase, CMGC CDK 0.0141 0.1299 1
Trypanosoma brucei trypanothione reductase 0.0051 0.0359 0.276
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0652 0.1259
Echinococcus multilocularis cyclin dependent kinase 1 0.0141 0.1299 0.1445
Trichomonas vaginalis cyclin D, putative 0.0076 0.0617 0.1144
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0359 0.2188
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0652 0.1768
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1043 0.2025
Echinococcus multilocularis lamin 0.003 0.0141 0.0147
Brugia malayi Importin beta-1 subunit 0.0031 0.0149 0.0139
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0359 0.276
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0652 0.0637
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0016 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.001 0.0075
Echinococcus multilocularis cyclin dependent kinase 5 0.0141 0.1299 0.1445
Brugia malayi Regulator of G protein signaling domain containing protein 0.0031 0.0148 0.0139
Trypanosoma cruzi cdc2-related kinase 1 0.0141 0.1299 1
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0178 0.0463
Trichomonas vaginalis cyclin B, putative 0.0018 0.0016 0.0012
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0141 0.1299 1
Echinococcus multilocularis Cyclin L1 0.0018 0.0016 0.0007
Entamoeba histolytica cell division protein kinase 2, putative 0.0141 0.1299 1
Echinococcus multilocularis axis inhibition protein axin 0.0031 0.0148 0.0155
Brugia malayi RNA, U transporter 1 0.0088 0.0746 0.0737
Echinococcus multilocularis musashi 0.003 0.0141 0.0147
Brugia malayi hypothetical protein 0.0018 0.0016 0.0006
Brugia malayi hypothetical protein 0.0031 0.0148 0.0139
Toxoplasma gondii hypothetical protein 0.0059 0.0438 0.2685
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1043 0.2025
Entamoeba histolytica protein kinase , putative 0.0127 0.1152 0.8857
Trichomonas vaginalis cyclin B, putative 0.0102 0.0888 0.1655
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0083 0.0228
Leishmania major hypothetical protein, conserved 0.0034 0.0178 0.137
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0517 0.0569
Leishmania major mitotic cyclin, putative 0.0018 0.0016 0.0123
Echinococcus granulosus importin subunit beta 1 0.0031 0.0149 0.0383
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0034 0.0182 0.0173
Trypanosoma cruzi CYC2-like cyclin, putative 0.0102 0.0888 0.6838
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0087 0.0146
Trichomonas vaginalis cyclins, putative 0.0044 0.0287 0.0522
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0018 0.0016 0.0007
Loa Loa (eye worm) intermediate filament protein 0.003 0.0141 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1152 0.2152
Brugia malayi Probable ClpP-like protease 0.0171 0.1604 0.1596
Loa Loa (eye worm) RGS-3 protein 0.0031 0.0148 0.0132
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0652 0.1836
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0438 0.2685
Echinococcus granulosus cyclin G2 0.0018 0.0016 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0085 0.0713 0.1935
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0018 0.0016 0.0123
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.1415 0.387
Trichomonas vaginalis cyclins, putative 0.0018 0.0016 0.0012
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0018 0.0016 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0141 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.1299 0.3567
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0141 0.1299 0.1285
Mycobacterium tuberculosis Conserved protein 0.0079 0.0652 0.1259
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0178 0.1056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.1171 0.3217
Trichomonas vaginalis cyclin B, putative 0.0076 0.0617 0.1144
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0178 0.0489
Loa Loa (eye worm) hypothetical protein 0.0079 0.0652 0.0637
Trypanosoma cruzi aurora B kinase, putative 0.0127 0.1152 0.8871
Trichomonas vaginalis cyclins, putative 0.0018 0.0016 0.0012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0435 0.117
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.0148 0.0155
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0361 0.0966
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.2482 0.2769
Brugia malayi Bromodomain containing protein 0.0086 0.0724 0.0715
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.012
Echinococcus granulosus cyclins 0.0076 0.0617 0.1673
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.001 0.0075
Loa Loa (eye worm) acetyltransferase 0.016 0.1488 0.1475
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0018 0.0016 0.0007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Schistosoma mansoni cyclin k 0.0018 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0132 0.1201 0.1187
Mycobacterium tuberculosis Conserved protein 0.0079 0.0652 0.1259
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.1299 0.3567
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0517 0.142
Brugia malayi beta-lactamase family protein 0.0079 0.0652 0.0643
Schistosoma mansoni regulator of G protein signaling 0.0031 0.0148 0.0407
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0435 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0517 0.142
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.1604 1
Entamoeba histolytica cyclin family protein 0.0076 0.0617 0.4687
Onchocerca volvulus 0.003 0.0141 0.0125
Brugia malayi serine/threonine kinase 12 0.0127 0.1152 0.1144
Schistosoma mansoni cyclin l 0.0018 0.0016 0.0044
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0652 0.1259
Echinococcus multilocularis regulator of G protein signaling 3 0.0031 0.0148 0.0155
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0162
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0076 0.0617 0.0681
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Loa Loa (eye worm) hypothetical protein 0.0051 0.0354 0.0338
Brugia malayi Cyclin, N-terminal domain containing protein 0.0076 0.0617 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0012
Brugia malayi cyclin fold protein 1 variant b 0.0018 0.0016 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.001 0.0075
Echinococcus granulosus regulator of G protein signaling 3 0.0031 0.0148 0.0381
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0333 0.2028
Echinococcus granulosus cyclin B 0.0102 0.0888 0.2419
Brugia malayi regulator of G-protein signaling rgs-7 0.0031 0.0148 0.0139
Schistosoma mansoni cyclin G2 0.0018 0.0016 0.0044
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0266 0.1987
Echinococcus granulosus cyclin 0.0018 0.0016 0.0017
Brugia malayi hypothetical protein 0.004 0.0237 0.0228
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0132
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0361 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.2977 0.8173
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0237 0.0255
Leishmania major hypothetical protein, conserved 0.0079 0.0652 0.5017
Brugia malayi serine/threonine protein kinase 6 0.0127 0.1152 0.1144
Schistosoma mansoni bromodomain containing protein 0.0073 0.059 0.162
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0463 0.4653 0.4644
Loa Loa (eye worm) hypothetical protein 0.0138 0.1265 0.1251
Echinococcus granulosus axis inhibition protein axin 0.0031 0.0148 0.0381
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0127 0.1152 0.7168
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0018 0.0016 0.0017
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0171 0.1604 0.1786
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0266 0.1607
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0162
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0018 0.0016 0.0039
Plasmodium vivax JmjC domain containing protein 0.0034 0.0178 0.1056
Echinococcus multilocularis G1:S specific cyclin D1 0.0018 0.0016 0.0007
Brugia malayi PHD-finger family protein 0.0031 0.015 0.0141
Entamoeba histolytica cell division protein kinase 2, putative 0.0141 0.1299 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0016 0.0006
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0178 0.137
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0018 0.0016 0.0039
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0178 0.0463
Echinococcus multilocularis Protein lozenge 0.0122 0.1101 0.1223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0713 0.1957
Leishmania major cyclin 9, putative 0.0018 0.0016 0.0123
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0178 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0132
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0087 0.0673
Schistosoma mansoni cyclins 0.0076 0.0617 0.1695
Loa Loa (eye worm) beta-lactamase 0.0079 0.0652 0.0637
Brugia malayi PXA domain containing protein 0.0031 0.0148 0.0139
Plasmodium vivax glutathione reductase, putative 0.0051 0.0359 0.2188
Trichomonas vaginalis cyclin A, putative 0.0102 0.0888 0.1655
Echinococcus multilocularis peptidase Clp (S14 family) 0.0112 0.0991 0.1099
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.001 0.0075
Leishmania major cyclin 0.0102 0.0888 0.6838
Schistosoma mansoni lozenge 0.0122 0.1101 0.3023
Echinococcus granulosus lamin 0.003 0.0141 0.0362
Onchocerca volvulus 0.0079 0.0652 0.0637
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0127 0.1152 0.8857
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0031 0.0148 0.0407
Brugia malayi intermediate filament protein 0.003 0.0141 0.0132
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0361 0.0966
Trypanosoma brucei mitotic cyclin 6 0.0102 0.0888 0.6838
Loa Loa (eye worm) AUR protein kinase 0.0127 0.1152 0.1138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0171 0.1604 1
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0067 0.0051
Trypanosoma cruzi mitotic cyclin, putative 0.0018 0.0016 0.0123
Toxoplasma gondii thioredoxin reductase 0.0051 0.0359 0.2188
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0549 0.0604
Onchocerca volvulus Huntingtin homolog 0.0132 0.1201 0.1187
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0085 0.0713 0.0698
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0016 0.0006
Echinococcus multilocularis cyclin t1 0.0018 0.0016 0.0007
Trypanosoma cruzi cyclin 6, putative 0.0102 0.0888 0.6838
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.02 0.0213
Loa Loa (eye worm) AUR protein kinase 0.0127 0.1152 0.1138
Schistosoma mansoni zinc finger protein 0.0025 0.0089 0.0245
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0149 0.1144
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.002 0.0029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0367 0.0357
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1043 0.2025
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0652 0.1209
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0492 0.1327
Onchocerca volvulus 0.0079 0.0652 0.0637
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0016 0.0012
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.02 0.0524
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.0148 0.0381
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0359 0.0343
Echinococcus multilocularis cyclin 0.0018 0.0016 0.0007
Echinococcus granulosus G protein coupled receptor kinase 1 0.0271 0.2653 0.7278
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0171 0.1604 0.4389
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1178 0.2292
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1152 0.3164
Plasmodium falciparum importin beta, putative 0.0031 0.0149 0.0872
Loa Loa (eye worm) hypothetical protein 0.0976 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0148 0.0261
Echinococcus multilocularis regulator of G protein signaling 0.0031 0.0148 0.0155
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0016 0.0006
Entamoeba histolytica cyclin, putative 0.0102 0.0888 0.6799
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0018 0.0016 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0652 0.179
Echinococcus granulosus G1:S specific cyclin D1 0.0018 0.0016 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0652 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0012
Echinococcus multilocularis snurportin 1 0.0332 0.3283 0.3667
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0359 0.0391
Loa Loa (eye worm) hypothetical protein 0.0079 0.0652 0.0637
Echinococcus multilocularis cyclin B 0.0102 0.0888 0.0984
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0236 0.0624
Echinococcus granulosus cyclin k 0.0018 0.0016 0.0017
Trichomonas vaginalis cyclin D, putative 0.0076 0.0617 0.1144
Trichomonas vaginalis cyclin B, putative 0.0018 0.0016 0.0012
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0361 0.099
Echinococcus granulosus lamin dm0 0.003 0.0141 0.0362
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.001 0.0075
Trichomonas vaginalis cyclins, putative 0.0076 0.0617 0.1144
Echinococcus multilocularis cyclin A3 4 0.0018 0.0016 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0333 0.2028
Echinococcus granulosus Cyclin L1 0.0018 0.0016 0.0017
Loa Loa (eye worm) PXA domain-containing protein 0.0031 0.0148 0.0132
Loa Loa (eye worm) hypothetical protein 0.0059 0.0435 0.042
Trichomonas vaginalis cyclin D, putative 0.0018 0.0016 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0236 0.0254
Loa Loa (eye worm) hypothetical protein 0.0051 0.0361 0.0345
Echinococcus multilocularis cyclin G2 0.0018 0.0016 0.0007
Giardia lamblia Hypothetical protein 0.0018 0.0016 0.0049
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0178 0.0489
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0087 0.0146
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0061 0.0045
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0361 0.0345
Schistosoma mansoni regulator of G protein signaling 0.0031 0.0148 0.0407
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0149 0.0156
Schistosoma mansoni intermediate filament proteins 0.003 0.0141 0.0388
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.002 0.0012
Entamoeba histolytica hypothetical protein 0.004 0.0237 0.1723
Echinococcus granulosus expressed protein 0.0031 0.0148 0.0381
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.1178 0.6352
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0178 0.0162
Schistosoma mansoni g1/s-specific cyclin C 0.0018 0.0016 0.0044
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0132
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1488 0.4087
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0168
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0031 0.0148 0.0407
Echinococcus granulosus cyclin dependent kinase 0.0141 0.1299 0.355
Giardia lamblia Hypothetical protein 0.0018 0.0016 0.0049
Echinococcus multilocularis cyclin B3 1 0.0076 0.0617 0.0681
Entamoeba histolytica cyclin family protein 0.0076 0.0617 0.4687
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0178 0.0489
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0361 0.099
Echinococcus multilocularis Regulator of G protein signaling 20 0.0031 0.0148 0.0155
Plasmodium vivax protein kinase Crk2 0.0141 0.1299 0.8088
Brugia malayi Cyclin, N-terminal domain containing protein 0.0782 0.7982 0.798
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0435 0.1194
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0178 0.0162
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0031 0.0148 0.0155
Plasmodium vivax cyclin 4, putative 0.0018 0.0016 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.2482 0.6806
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0112 0.0991 0.1924
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0148 0.0261
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0332 0.0316
Giardia lamblia Aurora kinase 0.0127 0.1152 0.8862
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0652 0.1259
Onchocerca volvulus 0.0527 0.532 0.5312
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0333 0.2028
Plasmodium falciparum serine/threonine protein kinase, putative 0.0127 0.1152 0.7168
Schistosoma mansoni survival motor neuron protein 0.0052 0.0367 0.1007
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0168
Giardia lamblia Kinase, CMGC CDK 0.0141 0.1299 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1043 0.2025
Echinococcus granulosus cyclins 0.0076 0.0617 0.1673
Entamoeba histolytica hypothetical protein 0.004 0.0237 0.1723
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0333 0.089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0652 0.179
Trichomonas vaginalis cyclins, putative 0.0102 0.0888 0.1655
Loa Loa (eye worm) hypothetical protein 0.0079 0.0652 0.0637
Trichomonas vaginalis cyclin B, putative 0.0102 0.0888 0.1655
Plasmodium vivax importin-beta 2, putative 0.0031 0.0149 0.0872
Trypanosoma cruzi cyclin 9, putative 0.0018 0.0016 0.0123
Trichomonas vaginalis set domain proteins, putative 0.0527 0.532 1
Echinococcus granulosus cyclin y 0.0018 0.0016 0.0017
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0333 0.0609
Plasmodium falciparum thioredoxin reductase 0.0051 0.0359 0.2188
Loa Loa (eye worm) hypothetical protein 0.0102 0.0888 0.0874
Onchocerca volvulus 0.0102 0.0888 0.0874
Toxoplasma gondii cyclin 4, putative 0.0018 0.0016 0.0039
Schistosoma mansoni hypothetical protein 0.0023 0.0061 0.0168
Entamoeba histolytica protein kinase, putative 0.0127 0.1152 0.8857
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0083 0.0202
Schistosoma mansoni cyclin B3 0.0076 0.0617 0.1695
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0435 0.117
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0078 0.0635 0.062
Entamoeba histolytica hypothetical protein 0.004 0.0237 0.1723
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0141 0.0125
Loa Loa (eye worm) hypothetical protein 0.0171 0.1604 0.159
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0549 0.1485
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Trichomonas vaginalis cyclins, putative 0.0102 0.0888 0.1655
Loa Loa (eye worm) MBCTL1 0.0059 0.0435 0.042
Echinococcus granulosus regulator of G protein signaling 3 0.0031 0.0148 0.0381
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0018 0.0016 0.0039
Echinococcus multilocularis beta adrenergic receptor kinase 0.0302 0.2977 0.3324
Echinococcus granulosus cyclins 0.0076 0.0617 0.1673
Trypanosoma cruzi cyclin, putative 0.0102 0.0888 0.6838
Plasmodium vivax SET domain protein, putative 0.0066 0.0517 0.3183
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0127 0.115 0.1277
Toxoplasma gondii hypothetical protein 0.0058 0.0426 0.2612
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0652 0.0719
Entamoeba histolytica hypothetical protein 0.0031 0.0148 0.103
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0178 0.0162
Brugia malayi jmjC domain containing protein 0.0127 0.115 0.1141
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0178 0.0189
Trypanosoma cruzi cyclin, putative 0.0102 0.0888 0.6838
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0652 0.1259
Echinococcus multilocularis cyclin G2 0.0018 0.0016 0.0007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1043 0.2025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.3283 0.3273
Echinococcus multilocularis cyclin k 0.0018 0.0016 0.0007
Giardia lamblia Cyclin B-like protein 0.0018 0.0016 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1152 0.2152
Brugia malayi hypothetical protein 0.0255 0.2482 0.2474
Loa Loa (eye worm) hypothetical protein 0.0042 0.0264 0.0249
Entamoeba histolytica hypothetical protein 0.0025 0.0087 0.0557
Loa Loa (eye worm) hypothetical protein 0.0079 0.0652 0.0637
Onchocerca volvulus 0.0976 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0652 0.5017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.0438 0.2685
Brugia malayi Bromodomain containing protein 0.0046 0.0304 0.0294
Loa Loa (eye worm) hypothetical protein 0.0976 1 1
Echinococcus granulosus cyclin G2 0.0018 0.0016 0.0017
Echinococcus granulosus cyclin t1 0.0018 0.0016 0.0017
Echinococcus multilocularis cyclin b3 0.0076 0.0617 0.0681
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0149 0.0872
Trichomonas vaginalis cyclin B, putative 0.0102 0.0888 0.1655
Brugia malayi hypothetical protein 0.0031 0.0148 0.0139
Leishmania major importin beta-1 subunit, putative 0.0025 0.0087 0.0673
Mycobacterium tuberculosis Probable reductase 0.0117 0.1043 0.2025
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0266 0.1947
Loa Loa (eye worm) cyclin domain-containing protein 0.0076 0.0617 0.0602
Loa Loa (eye worm) runx1 0.0122 0.1101 0.1087
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0102 0.0888 0.6838
Loa Loa (eye worm) hypothetical protein 0.0132 0.1201 0.1187
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0652 0.4028
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0652 0.1259
Brugia malayi Cyclin C 0.0018 0.0016 0.0006
Echinococcus granulosus cyclins 0.0076 0.0617 0.1673
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0178 0.0489
Giardia lamblia Cyclin A 0.0076 0.0617 0.4712
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0127 0.115 0.3138
Echinococcus granulosus aurora kinase A 0.0127 0.1152 0.3146
Brugia malayi beta-lactamase family protein 0.0079 0.0652 0.0643
Echinococcus multilocularis axis inhibition protein axin 0.0031 0.0148 0.0155
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1937 0.5305
Schistosoma mansoni hypothetical protein 0.0366 0.3642 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.008
Giardia lamblia Cyclin fold protein 1, putative 0.0018 0.0016 0.0049
Echinococcus multilocularis cyclin y 0.0018 0.0016 0.0007
Brugia malayi serine/threonine-protein kinase 6 0.0127 0.1152 0.1144
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0148 0.0261
Echinococcus granulosus intermediate filament protein 0.003 0.0141 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0031 0.0148 0.0407
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0127 0.1152 0.8857
Brugia malayi Pre-SET motif family protein 0.0066 0.0517 0.0508
Echinococcus multilocularis cyclins 0.0076 0.0617 0.0681
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0168
Mycobacterium ulcerans lipase LipD 0.0079 0.0652 0.4028
Toxoplasma gondii cyclin dependent kinase binding protein 0.0018 0.0016 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.1299 0.2428
Echinococcus granulosus cyclin y 0.0018 0.0016 0.0017
Onchocerca volvulus 0.0052 0.0367 0.0351
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0237 0.0626
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.1604 1
Echinococcus granulosus cyclins 0.0076 0.0617 0.1673
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0652 0.1209
Brugia malayi jmjC domain containing protein 0.0129 0.1171 0.1163
Echinococcus multilocularis cyclin dependent kinase 0.0141 0.1299 0.1445
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.1604 1
Trypanosoma cruzi cdc2-related kinase 3 0.0141 0.1299 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.1171 0.3217

Activities

Activity type Activity value Assay description Source Reference
GMS activity (functional) = 202 Evaluated for gastrointestinal motor stimulating (GMS) activity in dog estimated in vivo by 2 x 2 points parallel line assay. Activity of EM-A was assumed to be 1 ChEMBL. 3669001
MIC (functional) > 100 ug ml-1 Antibacterial activity against Staphylococcus aureus ATCC 6538P ChEMBL. 3669001
MIC (functional) > 100 ug ml-1 Antibacterial activity against Bacillus subtilis ATCC 6633 ChEMBL. 3669001
MIC (functional) > 100 ug ml-1 Antibacterial activity against Bacillus cereus IFO 3001 ChEMBL. 3669001
MIC (functional) > 100 ug ml-1 Antibacterial activity against Escherichia coli NIHJ ChEMBL. 3669001
MIC (functional) > 100 ug ml-1 Antibacterial activity against Klebsiella pneumoniae ATCC 10031 ChEMBL. 3669001
MIC (functional) > 100 ug ml-1 Antibacterial activity against Escherichia coli NIHJ ChEMBL. 3669001

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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