Detailed information for compound 867309

Basic information

Technical information
  • TDR Targets ID: 867309
  • Name: methyl 4-[3-[(2-ethyl-3-oxo-4H-1,4-benzothiaz in-6-yl)sulfonyl]propanoylamino]benzoate
  • MW: 462.539 | Formula: C21H22N2O6S2
  • H donors: 2 H acceptors: 5 LogP: 2.24 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1Sc2ccc(cc2NC1=O)S(=O)(=O)CCC(=O)Nc1ccc(cc1)C(=O)OC
  • InChi: 1S/C21H22N2O6S2/c1-3-17-20(25)23-16-12-15(8-9-18(16)30-17)31(27,28)11-10-19(24)22-14-6-4-13(5-7-14)21(26)29-2/h4-9,12,17H,3,10-11H2,1-2H3,(H,22,24)(H,23,25)
  • InChiKey: LKJNNLYCLJCNDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[3-[(2-ethyl-3-oxo-4H-1,4-benzothiazin-6-yl)sulfonyl]-1-oxopropyl]amino]benzoic acid methyl ester
  • 4-[3-[(2-ethyl-3-keto-4H-1,4-benzothiazin-6-yl)sulfonyl]propanoylamino]benzoic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) tubulin alpha 2 0.0099 0.1197 0.1869
Giardia lamblia Beta tubulin 0.0461 0.6404 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0056 0.0585 0.0585
Loa Loa (eye worm) ABC transporter 0.0034 0.0258 0.0403
Echinococcus granulosus tubulin alpha 1C chain 0.0349 0.4789 0.4789
Trichomonas vaginalis tubulin alpha chain, putative 0.0141 0.1807 0.2098
Brugia malayi ABC transporter family protein 0.0034 0.0258 0.0403
Trichomonas vaginalis tubulin epsilon chain, putative 0.0108 0.1334 0.1285
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0033 0.0252 0.0405
Trichomonas vaginalis tubulin alpha chain, putative 0.0141 0.1807 0.2098
Leishmania major beta tubulin 0.0461 0.6404 1
Plasmodium falciparum tubulin epsilon chain, putative 0.025 0.3366 0.5186
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0056 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0169 0.2198 0.2198
Giardia lamblia Epsilon tubulin 0.0108 0.1334 0.172
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0255 0.3436 0.8572
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0108 0.1334 0.1965
Echinococcus granulosus RUN 0.0119 0.1484 0.1484
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0022 0.0094 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Leishmania major beta tubulin 0.0461 0.6404 1
Leishmania major gamma-tubulin 0.025 0.3366 0.5186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0125 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0125 0.0196
Trichomonas vaginalis tubulin gamma chain, putative 0.025 0.3366 0.4778
Leishmania major beta tubulin 0.0461 0.6404 1
Schistosoma mansoni lipoxygenase 0.0711 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0487 0.0761
Trypanosoma brucei beta tubulin 0.0461 0.6404 1
Loa Loa (eye worm) tubulin alpha chain 0.0349 0.4789 0.7478
Echinococcus multilocularis tubulin subunit TubB 0.0349 0.4789 0.4789
Echinococcus granulosus Tubulin alpha 1 chain 0.0349 0.4789 0.4789
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0125 0.0125
Echinococcus granulosus tubulin beta 4A class IVa 0.0461 0.6404 0.6404
Brugia malayi Tubulin beta chain 0.0108 0.1334 0.2083
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0293 0.3993 1
Plasmodium vivax unspecified product 0.0104 0.1275 0.1872
Loa Loa (eye worm) hypothetical protein 0.0056 0.0585 0.0914
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0676 0.0676
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0125 0.0196
Leishmania major beta tubulin 0.0461 0.6404 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0349 0.4789 0.7223
Schistosoma mansoni alpha tubulin 0.0349 0.4789 0.4789
Echinococcus granulosus Tubulin beta 2C chain 0.0461 0.6404 0.6404
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0125 0.0196
Echinococcus multilocularis tubulin beta 1 chain 0.0461 0.6404 0.6404
Echinococcus granulosus tubulin alpha 0.025 0.3366 0.3366
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0487 0.0761
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1433 0.1433
Echinococcus multilocularis tubulin alpha chain 0.0349 0.4789 0.4789
Trypanosoma brucei zeta tubulin 0.0108 0.1334 0.1632
Echinococcus granulosus Tubulin beta 2C chain 0.0461 0.6404 0.6404
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0125 0.0125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0125 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1482 0.2314
Trypanosoma brucei beta tubulin 0.0461 0.6404 1
Echinococcus granulosus alpha tubulin 0.0349 0.4789 0.4789
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1415 0.3952
Schistosoma mansoni tubulin subunit beta 0.0461 0.6404 0.6404
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0387 0.0387
Trypanosoma brucei beta tubulin 0.0461 0.6404 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1415 0.2209
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0108 0.1334 0.1285
Plasmodium falciparum ABC transporter G family member 2 0.004 0.0345 0.0398
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0141 0.1807 0.2098
Schistosoma mansoni lipoxygenase 0.0497 0.6923 0.6923
Trypanosoma cruzi epsilon tubulin, putative 0.025 0.3366 0.5186
Brugia malayi RNA binding protein 0.0063 0.0676 0.1055
Echinococcus multilocularis beta tubulin 0.0461 0.6404 0.6404
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1415 0.2093
Echinococcus granulosus netrin receptor unc 5 0.0056 0.0585 0.0585
Echinococcus granulosus ATP binding cassette sub family G 0.004 0.0345 0.0345
Echinococcus granulosus tubulin subunit beta 0.0461 0.6404 0.6404
Giardia lamblia Kinase, PLK 0.0114 0.1415 0.1852
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1415 0.2093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0125 0.0125
Echinococcus granulosus tubulin alpha 1C chain 0.0349 0.4789 0.4789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0125 0.0196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Schistosoma mansoni amine oxidase 0.0022 0.0094 0.0094
Echinococcus granulosus tubulin delta chain 0.0108 0.1334 0.1334
Schistosoma mansoni tubulin subunit epsilon 0.025 0.3366 0.3366
Loa Loa (eye worm) hypothetical protein 0.0179 0.2343 0.3658
Schistosoma mansoni ankyrin 23/unc44 0.0056 0.0585 0.0585
Schistosoma mansoni alpha tubulin 0.0349 0.4789 0.4789
Plasmodium vivax unspecified product 0.0112 0.1382 0.2041
Echinococcus multilocularis geminin 0.0169 0.2198 0.2198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0281 0.0438
Echinococcus multilocularis ATP binding cassette sub family G 0.004 0.0345 0.0345
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0345 0.0595
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0479 0.0479
Schistosoma mansoni tubulin subunit alpha 0.0349 0.4789 0.4789
Entamoeba histolytica tubulin gamma chain 0.025 0.3366 0.4986
Brugia malayi PHD-finger family protein 0.0035 0.0281 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0125 0.0196
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0125 0.0196
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.004 0.0345 0.0345
Brugia malayi TAR-binding protein 0.0063 0.0676 0.1055
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0125 0.0196
Echinococcus multilocularis Tubulin beta 2C chain 0.0461 0.6404 0.6404
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Giardia lamblia Alpha-tubulin 0.0349 0.4789 0.7362
Loa Loa (eye worm) tubulin alpha chain 0.0349 0.4789 0.7478
Schistosoma mansoni amine oxidase 0.0022 0.0094 0.0094
Brugia malayi Tubulin alpha-2 chain 0.0349 0.4789 0.7478
Echinococcus multilocularis tubulin alpha 1C chain 0.0349 0.4789 0.4789
Echinococcus multilocularis protoporphyrinogen oxidase 0.0022 0.0094 0.0094
Brugia malayi nuclear hormone receptor 0.0024 0.0125 0.0196
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0125 0.0125
Loa Loa (eye worm) tubulin beta chain 0.0461 0.6404 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0207 0.2756 0.373
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0086 0.1012 0.1012
Plasmodium falciparum tubulin beta chain 0.0461 0.6404 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0125 0.0125
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0086 0.1012 0.1012
Loa Loa (eye worm) BEN-1 protein 0.0461 0.6404 1
Schistosoma mansoni hypothetical protein 0.0033 0.0252 0.0252
Echinococcus multilocularis Tubulin beta 2C chain 0.0461 0.6404 0.6404
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Echinococcus multilocularis Tubulin beta 2C chain 0.0461 0.6404 0.6404
Echinococcus granulosus Polycystic kidney disease protein 0.0119 0.1484 0.1484
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0094 0.0094
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0125 0.0125
Echinococcus granulosus tubulin alpha chain 0.0349 0.4789 0.4789
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.1484 0.1484
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Giardia lamblia Alpha-tubulin 0.0349 0.4789 0.7362
Loa Loa (eye worm) tubulin beta chain 0.0108 0.1334 0.2083
Trypanosoma brucei beta tubulin 0.025 0.3366 0.4986
Trichomonas vaginalis tubulin alpha chain, putative 0.0141 0.1807 0.2098
Echinococcus multilocularis RUN 0.0119 0.1484 0.1484
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0387 0.0387
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Loa Loa (eye worm) alpha-tubulin 0.0349 0.4789 0.7478
Schistosoma mansoni hypothetical protein 0.0119 0.1484 0.1484
Plasmodium vivax ABC transporter G family member 2, putative 0.004 0.0345 0.0398
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0281 0.0438
Echinococcus multilocularis Tubulin alpha 1 chain 0.0349 0.4789 0.4789
Echinococcus granulosus tubulin epsilon chain 0.025 0.3366 0.3366
Giardia lamblia ABC transporter 0.0039 0.0338 0.0094
Schistosoma mansoni tubulin subunit gamma 0.025 0.3366 0.3366
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0125 0.0125
Leishmania major beta tubulin 0.0461 0.6404 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0711 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.2343 0.6729
Trypanosoma brucei alpha tubulin 0.0349 0.4789 0.7334
Trypanosoma brucei beta tubulin 0.0461 0.6404 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0345 0.0595
Loa Loa (eye worm) tubulin alpha 2 0.024 0.3229 0.5042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0281 0.0281
Echinococcus granulosus death domain containing protein 0.0056 0.0585 0.0585
Echinococcus granulosus Tubulin beta 2C chain 0.0461 0.6404 0.6404
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0125 0.0125
Plasmodium vivax tubulin alpha chain, putative 0.0349 0.4789 0.744
Brugia malayi N-terminal motif family protein 0.0179 0.2343 0.3658
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0676 0.0676
Brugia malayi Tubulin beta-1 chain 0.0461 0.6404 1
Trichomonas vaginalis tubulin beta chain, putative 0.0461 0.6404 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0147
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0094 0.5
Brugia malayi Tubulin alpha chain 0.0108 0.1334 0.2083
Trichomonas vaginalis tubulin gamma chain, putative 0.0461 0.6404 1
Brugia malayi tubulin alpha-2 chain 0.0349 0.4789 0.7478
Schistosoma mansoni tubulin subunit delta 0.0108 0.1334 0.1334
Loa Loa (eye worm) tubulin alpha-3 chain 0.0207 0.2756 0.4304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0125 0.0125
Brugia malayi Protein kinase domain containing protein 0.0057 0.0591 0.0922
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0094 0.0094
Echinococcus multilocularis Tubulin alpha 1 chain 0.0349 0.4789 0.4789
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0125 0.0196
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.4789 0.7223
Plasmodium falciparum cysteine proteinase falcipain 1 0.0112 0.1382 0.2041
Plasmodium falciparum tubulin gamma chain 0.025 0.3366 0.5186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0147
Schistosoma mansoni tubulin subunit alpha 0.0108 0.1334 0.1334
Loa Loa (eye worm) hypothetical protein 0.0119 0.1484 0.2317
Echinococcus multilocularis tubulin epsilon chain 0.025 0.3366 0.3366
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1415 0.2209
Leishmania major beta tubulin 0.0461 0.6404 1
Schistosoma mansoni rab6-interacting 0.0119 0.1484 0.1484
Trypanosoma brucei alpha tubulin 0.0349 0.4789 0.7334
Loa Loa (eye worm) beta-tubulin 0.0461 0.6404 1
Leishmania major beta tubulin 0.0461 0.6404 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0125 0.0196
Loa Loa (eye worm) alpha-tubulin isotype 2 0.024 0.3229 0.5042
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1482 0.2314
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0125 0.0125
Echinococcus multilocularis tubulin alpha 0.025 0.3366 0.3366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0125 0.0196
Echinococcus granulosus beta tubulin 0.0461 0.6404 0.6404
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0255 0.3436 0.5365
Schistosoma mansoni hypothetical protein 0.0056 0.0585 0.0585
Echinococcus granulosus Tubulin beta 2C chain 0.0461 0.6404 0.6404
Brugia malayi alpha-tubulin 0.0349 0.4789 0.7478
Trypanosoma brucei zeta tubulin, putative 0.0108 0.1334 0.1632
Echinococcus granulosus Tubulin alpha 1 chain 0.0349 0.4789 0.4789
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0676 0.1055
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.1484 0.1484
Loa Loa (eye worm) doublecortin family protein 0.0119 0.1484 0.2317
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.024 0.3229 0.4543
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0255 0.3436 0.7923
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0125 0.0196
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0585 0.0914
Brugia malayi MH2 domain containing protein 0.0119 0.1482 0.2314
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0255 0.3436 0.5153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0125 0.0196
Brugia malayi Tubulin beta chain 0.0141 0.1807 0.2821
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0125 0.0125
Brugia malayi nuclear receptor NHR-88 0.0024 0.0125 0.0196
Onchocerca volvulus Alhambra homolog 0.0035 0.0281 0.0559
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0255 0.3436 0.4898
Entamoeba histolytica tubulin alpha chain, putative 0.0349 0.4789 0.7334
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1092 0.1092
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0108 0.1334 0.1965
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0022 0.0094 0.0094
Trypanosoma brucei epsilon tubulin 0.025 0.3366 0.4986
Schistosoma mansoni tubulin subunit beta 0.0461 0.6404 0.6404
Brugia malayi Cell division protein ftsZ 0.0108 0.1334 0.2083
Loa Loa (eye worm) tubulin alpha 2 0.024 0.3229 0.5042
Plasmodium vivax multidomain scavenger receptor, putative 0.0119 0.1484 0.2203
Loa Loa (eye worm) tubulin gamma chain 0.025 0.3366 0.5256
Loa Loa (eye worm) hypothetical protein 0.0349 0.4789 0.7478
Leishmania major epsilon tubulin, putative 0.025 0.3366 0.5186
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0676 0.1055
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0262 0.0409
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0479 0.0479
Echinococcus multilocularis ATP binding cassette sub family G 0.004 0.0345 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0387 0.0605
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Schistosoma mansoni tubulin subunit beta 0.0461 0.6404 0.6404
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0094 0.0147
Trichomonas vaginalis tubulin epsilon chain, putative 0.0349 0.4789 0.7223
Schistosoma mansoni tubulin subunit beta 0.0461 0.6404 0.6404
Toxoplasma gondii alpha-tubulin I, putative 0.0349 0.4789 0.744
Leishmania major beta tubulin 0.0461 0.6404 1
Leishmania major beta tubulin 0.0461 0.6404 1
Echinococcus granulosus tubulin alpha chain 0.0349 0.4789 0.4789
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0255 0.3436 0.4898
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0125 0.0196
Echinococcus granulosus tubulin alpha 3 chain 0.0349 0.4789 0.4789
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0147
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0125 0.0125
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.025 0.3366 0.5186
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0255 0.3436 0.4898
Echinococcus granulosus ATP binding cassette sub family G 0.004 0.0345 0.0345
Brugia malayi Tubulin alpha-2 chain 0.0349 0.4789 0.7478
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.004 0.0345 0.0398
Mycobacterium leprae cell division protein FtsZ 0.0108 0.1334 1
Schistosoma mansoni polycystin 1-related 0.0119 0.1484 0.1484
Trichomonas vaginalis tubulin gamma chain, putative 0.0108 0.1334 0.1285
Leishmania major beta tubulin 0.0461 0.6404 1
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.4789 0.7223
Trypanosoma cruzi tubulin delta chain 0.0108 0.1334 0.1965
Schistosoma mansoni tubulin subunit alpha 0.0349 0.4789 0.4789
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.004 0.0345 0.0398
Echinococcus multilocularis tubulin delta chain 0.0108 0.1334 0.1334
Schistosoma mansoni hypothetical protein 0.0035 0.0281 0.0281
Brugia malayi Uncoordinated protein 44 0.0056 0.0585 0.0914
Plasmodium vivax tubulin epsilon chain, putative 0.025 0.3366 0.5186
Brugia malayi tubulin alpha chain - mouse 0.0349 0.4789 0.7478
Brugia malayi beta-tubulin, identical 0.0461 0.6404 1
Giardia lamblia Delta tubulin 0.0108 0.1334 0.172
Trypanosoma cruzi zeta tubulin, putative 0.0108 0.1334 0.1965
Plasmodium falciparum LCCL domain-containing protein 0.0119 0.1484 0.2203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0125 0.0196
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0255 0.3436 0.5365
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0125 0.0125
Trichomonas vaginalis tubulin epsilon chain, putative 0.0349 0.4789 0.7223
Toxoplasma gondii alpha tubulin TUBA1 0.0349 0.4789 0.744
Schistosoma mansoni rab6-interacting 0.0119 0.1484 0.1484
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0281 0.0296
Echinococcus multilocularis tubulin alpha 3 chain 0.0349 0.4789 0.4789
Echinococcus granulosus tar DNA binding protein 0.0063 0.0676 0.0676
Toxoplasma gondii beta-tubulin, putative 0.0461 0.6404 1
Trypanosoma cruzi beta tubulin, putative 0.0461 0.6404 1
Leishmania major beta tubulin 0.0461 0.6404 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0125 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1415 0.1415
Leishmania major beta tubulin 0.0461 0.6404 1
Schistosoma mansoni tubulin subunit beta 0.0461 0.6404 0.6404
Schistosoma mansoni netrin receptor unc5 0.0056 0.0585 0.0585
Echinococcus granulosus tubulin alpha chain 0.0349 0.4789 0.4789
Trypanosoma brucei alpha tubulin, putative 0.0141 0.1807 0.2412
Schistosoma mansoni tubulin subunit beta 0.0108 0.1334 0.1334
Echinococcus granulosus tubulin alpha chain 0.0349 0.4789 0.4789
Leishmania major beta tubulin 0.0461 0.6404 1
Giardia lamblia Beta tubulin 0.0461 0.6404 1
Echinococcus multilocularis tubulin alpha chain 0.0349 0.4789 0.4789
Loa Loa (eye worm) tubulin beta-1 chain 0.0461 0.6404 1
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.4789 0.7223
Plasmodium falciparum tubulin delta chain, putative 0.0108 0.1334 0.1965
Loa Loa (eye worm) hypothetical protein 0.0034 0.0262 0.0409
Echinococcus multilocularis peroxisome assembly protein 26 0.0349 0.4789 0.4789
Treponema pallidum cell division protein FtsZ 0.0108 0.1334 0.5
Echinococcus granulosus tubulin alpha 3 chain 0.0349 0.4789 0.4789
Brugia malayi hypothetical protein 0.0119 0.1484 0.2317
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0125 0.0196
Plasmodium falciparum phd finger protein, putative 0.0035 0.0281 0.0296
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.4789 0.7223
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0255 0.3436 0.4898
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.006 0.0642 0.1003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.1484 0.1484
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Trypanosoma brucei tubulin gamma chain 0.025 0.3366 0.4986
Brugia malayi hypothetical protein 0.0119 0.1484 0.2317
Trichomonas vaginalis tubulin alpha chain, putative 0.025 0.3366 0.4778
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1433 0.1433
Trypanosoma brucei alpha tubulin 0.0349 0.4789 0.7334
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0086 0.1012 0.1012
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0125 0.0125
Echinococcus granulosus peroxisome assembly protein 26 0.0349 0.4789 0.4789
Trypanosoma brucei epsilon tubulin 0.025 0.3366 0.4986
Plasmodium vivax delta tubulin, putative 0.0108 0.1334 0.1965
Loa Loa (eye worm) tubulin alpha-2 chain 0.0349 0.4789 0.7478
Echinococcus granulosus tubulin gamma 1 chain 0.025 0.3366 0.3366
Brugia malayi SWIRM domain containing protein 0.0022 0.0094 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1334 0.1285
Trichomonas vaginalis tubulin beta chain, putative 0.0141 0.1807 0.2098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0487 0.0761
Onchocerca volvulus 0.0141 0.1807 0.5125
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.1484 0.1484
Trypanosoma cruzi tubulin gamma chain 0.025 0.3366 0.5186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0125 0.0125
Schistosoma mansoni tumor necrosis factor receptor related 0.0086 0.1012 0.1012
Echinococcus multilocularis 0.0022 0.0094 0.0094
Echinococcus multilocularis Tubulin beta 2C chain 0.0461 0.6404 0.6404
Leishmania major zeta tubulin, putative 0.0108 0.1334 0.1965
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0316 0.4312 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0316 0.4312 1
Trichomonas vaginalis tubulin, putative 0.0141 0.1807 0.2098
Brugia malayi steroid hormone receptor 0.0024 0.0125 0.0196
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0281 0.0296
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0125 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0125 0.0196
Echinococcus multilocularis tubulin subunit beta 0.0461 0.6404 0.6404
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0387 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0676 0.0676
Onchocerca volvulus 0.0255 0.3436 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Brugia malayi Doublecortin family protein 0.0119 0.1484 0.2317
Echinococcus granulosus tubulin alpha chain 0.0349 0.4789 0.4789
Echinococcus granulosus peregrin 0.0035 0.0281 0.0281
Entamoeba histolytica tubulin family protein 0.0461 0.6404 1
Brugia malayi Tubulin alpha chain 0.0349 0.4789 0.7478
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0125 0.0125
Loa Loa (eye worm) RNA binding protein 0.0063 0.0676 0.1055
Echinococcus multilocularis tubulin gamma 1 chain 0.025 0.3366 0.3366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0125 0.0196
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0125 0.0125
Plasmodium falciparum alpha tubulin 1 0.0349 0.4789 0.744
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0676 0.1055
Echinococcus multilocularis peregrin 0.0035 0.0281 0.0281
Loa Loa (eye worm) alpha-tubulin 0.0349 0.4789 0.7478
Schistosoma mansoni alpha tubulin 0.0349 0.4789 0.4789
Brugia malayi Tubulin gamma chain 0.025 0.3366 0.5256
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0108 0.1334 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0281 0.0296
Echinococcus multilocularis beta tubulin 0.0461 0.6404 0.6404
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0056 0.0585 0.0585
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0255 0.3436 0.4898
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0255 0.3436 0.5101
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Trichomonas vaginalis tubulin, putative 0.0108 0.1334 0.1285
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0125 0.0125
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.004 0.0345 0.0398
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0056 0.0585 0.0914
Trypanosoma cruzi zeta tubulin, putative 0.0108 0.1334 0.1965
Trypanosoma cruzi ATP-binding cassette protein, putative 0.004 0.0345 0.0398
Echinococcus multilocularis ATP binding cassette sub family G 0.004 0.0345 0.0345
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0255 0.3436 0.5101
Onchocerca volvulus 0.0024 0.0125 0.0094
Trypanosoma cruzi ABC transporter, putative 0.004 0.0345 0.0398
Toxoplasma gondii beta-1 tubulin, putative 0.0461 0.6404 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0349 0.4789 0.4789
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0461 0.6404 0.6404
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0125 0.0125
Schistosoma mansoni ABC transporter 0.0034 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0147
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0125 0.0125
Echinococcus multilocularis Tubulin beta 2C chain 0.0461 0.6404 0.6404
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0125 0.0094
Plasmodium falciparum alpha tubulin 2 0.0349 0.4789 0.744
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1415 0.1415
Echinococcus multilocularis netrin receptor unc 5 0.0056 0.0585 0.0585
Entamoeba histolytica tubulin alpha-1 chain 0.0349 0.4789 0.7334
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0086 0.1012 0.1012
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0125 0.0125
Echinococcus granulosus Tubulin beta 2C chain 0.0461 0.6404 0.6404
Echinococcus multilocularis tubulin alpha 1C chain 0.0349 0.4789 0.4789
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0676 0.0676
Echinococcus multilocularis Ankyrin 0.0056 0.0585 0.0585
Loa Loa (eye worm) tubulin beta-4 chain 0.0461 0.6404 1
Echinococcus multilocularis tubulin alpha chain 0.0349 0.4789 0.4789
Schistosoma mansoni coup transcription factor 0.0024 0.0125 0.0125
Brugia malayi Bromodomain containing protein 0.0035 0.0281 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0125 0.0196
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0125 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0125 0.0125
Entamoeba histolytica tubulin family protein 0.0461 0.6404 1
Schistosoma mansoni hypothetical protein 0.0169 0.2198 0.2198
Trichomonas vaginalis tubulin epsilon chain, putative 0.0461 0.6404 1
Echinococcus granulosus geminin 0.0169 0.2198 0.2198
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1334 0.1285
Brugia malayi Death domain containing protein 0.0056 0.0585 0.0914
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0387 0.0387
Mycobacterium tuberculosis Cell division protein FtsZ 0.0108 0.1334 0.3181
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.004 0.0345 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0676 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0676 0.0676
Onchocerca volvulus Netrin receptor homolog 0.0056 0.0585 0.147
Onchocerca volvulus 0.0119 0.1484 0.4159
Trypanosoma brucei epsilon tubulin 0.025 0.3366 0.4986
Echinococcus multilocularis tubulin alpha chain 0.0349 0.4789 0.4789
Leishmania major delta tubulin, putative 0.0108 0.1334 0.1965
Trypanosoma brucei tubulin delta chain 0.0108 0.1334 0.1632
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0125 0.0125
Schistosoma mansoni kinase 0.0058 0.0608 0.0608
Plasmodium vivax tubulin beta chain, putative 0.0461 0.6404 1
Leishmania major beta tubulin 0.0461 0.6404 1
Echinococcus granulosus tubulin subunit TubB 0.0349 0.4789 0.4789
Mycobacterium ulcerans cell division protein FtsZ 0.0108 0.1334 0.294
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0147
Echinococcus granulosus beta tubulin 0.0461 0.6404 0.6404
Loa Loa (eye worm) hypothetical protein 0.0056 0.0585 0.0914
Loa Loa (eye worm) hypothetical protein 0.0119 0.1484 0.2317
Echinococcus granulosus ATP binding cassette sub family G 0.004 0.0345 0.0345
Trichomonas vaginalis tubulin alpha chain, putative 0.0461 0.6404 1
Trypanosoma cruzi alpha tubulin, putative 0.0349 0.4789 0.744
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0255 0.3436 0.4898
Trypanosoma cruzi epsilon tubulin, putative 0.025 0.3366 0.5186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0125 0.0196
Trichomonas vaginalis tubulin gamma chain, putative 0.025 0.3366 0.4778
Schistosoma mansoni tubulin subunit alpha 0.0349 0.4789 0.4789
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.4789 0.7223
Giardia lamblia Beta tubulin 0.0461 0.6404 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.1415 0.1765
Leishmania major beta tubulin 0.0461 0.6404 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0125 0.0125
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1415 0.1415
Plasmodium vivax vivapain-1 0.0112 0.1382 0.2041
Loa Loa (eye worm) BEN-1 protein 0.0461 0.6404 1
Schistosoma mansoni tubulin subunit beta 0.0461 0.6404 0.6404
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1415 0.2093
Schistosoma mansoni loxhd1 0.0119 0.1484 0.1484
Leishmania major beta tubulin 0.0461 0.6404 1
Brugia malayi hypothetical protein 0.0022 0.0094 0.0147
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0281 0.0281
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0125 0.0125
Echinococcus multilocularis hypothetical protein 0.0349 0.4789 0.4789
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Leishmania major beta tubulin 0.0461 0.6404 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0125 0.0196
Trichomonas vaginalis tubulin beta chain, putative 0.0349 0.4789 0.7223
Echinococcus multilocularis Tubulin alpha 1 chain 0.0349 0.4789 0.4789
Toxoplasma gondii beta tubulin 0.0461 0.6404 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0022 0.0094 0.0094
Giardia lamblia Gamma tubulin 0.025 0.3366 0.5039
Onchocerca volvulus 0.0119 0.1484 0.4159
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0147
Trichomonas vaginalis tubulin, putative 0.0141 0.1807 0.2098
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Brugia malayi jmjC domain containing protein 0.0115 0.1433 0.2237
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1415 0.1424
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.082 0.128
Echinococcus granulosus Ankyrin 0.0056 0.0585 0.0585
Leishmania major beta tubulin 0.0461 0.6404 1
Plasmodium vivax tubulin gamma chain, putative 0.025 0.3366 0.5186
Loa Loa (eye worm) hypothetical protein 0.0207 0.2756 0.4304
Brugia malayi ecdysteroid receptor 0.0024 0.0125 0.0196
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0125 0.0125
Brugia malayi jmjC domain containing protein 0.0043 0.0387 0.0605
Echinococcus multilocularis tubulin alpha 3 chain 0.0349 0.4789 0.4789
Loa Loa (eye worm) hypothetical protein 0.024 0.3229 0.5042
Plasmodium vivax tubulin alpha chain, putative 0.0349 0.4789 0.744
Schistosoma mansoni hypothetical protein 0.0034 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0125 0.0196
Leishmania major alpha tubulin 0.0349 0.4789 0.744
Loa Loa (eye worm) tubulin beta-2A chain 0.0461 0.6404 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0487 0.0761
Trichomonas vaginalis tubulin epsilon chain, putative 0.0461 0.6404 1
Trypanosoma brucei alpha tubulin 0.0349 0.4789 0.7334
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1415 0.1765
Echinococcus multilocularis tubulin alpha chain 0.0349 0.4789 0.4789
Trichomonas vaginalis tubulin, putative 0.0461 0.6404 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0119 0.1484 0.1484
Trypanosoma cruzi tubulin delta chain 0.0108 0.1334 0.1965
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Echinococcus granulosus tubulin beta 1 chain 0.0461 0.6404 0.6404
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0125 0.0094
Loa Loa (eye worm) hypothetical protein 0.0024 0.0125 0.0196
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0281 0.0281
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0125 0.0196

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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