Detailed information for compound 879847

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.535 | Formula: C21H27N5O4S
  • H donors: 1 H acceptors: 5 LogP: 2.25 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CCCCCNC(=O)N1CCCN1C(=O)c1csc(n1)c1cccnc1
  • InChi: 1S/C21H27N5O4S/c1-2-30-18(27)9-4-3-5-11-23-21(29)26-13-7-12-25(26)20(28)17-15-31-19(24-17)16-8-6-10-22-14-16/h6,8,10,14-15H,2-5,7,9,11-13H2,1H3,(H,23,29)
  • InChiKey: XIXXDJQMLSYLFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0161 0.1271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0829 0.0806 0.8462
Plasmodium falciparum casein kinase II beta chain 0.004 0.0025 0.0782
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0006 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0135 0.1364
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0006 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.352 0.3473 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) hypothetical protein 0.0055 0.0039 0.0305
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0017 0.0203
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0859 0.0836 0.0835
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0276 0.0258 0.2665
Giardia lamblia Kinase, CMGC CK2 0.0151 0.0135 0.1421
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.0801 0.8408
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0798 0.0775 0.8137
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0009 0.0063
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0276 0.0258 0.1818
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0276 0.0258 0.2665
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.043 0.041 0.4312
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0355 0.0336 1
Schistosoma mansoni hypothetical protein 0.009 0.0074 0.052
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0212 0.0194 0.0528
Loa Loa (eye worm) hypothetical protein 0.0716 0.0694 0.5497
Loa Loa (eye worm) hypoxia-induced factor 1 0.0166 0.0149 0.1182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0849 0.0826 0.8674
Brugia malayi bHLH-PAS transcription factor 0.004 0.0024 0.025
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0037
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0151 0.0135 0.522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0178 0.0161 0.0457
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0212 0.0194 0.0194
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0009 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Schistosoma mansoni hypothetical protein 0.0338 0.0319 0.2253
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0118
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0869 0.0846 0.2431
Brugia malayi Death domain containing protein 0.0016 0 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0051 0.0142
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0585 0.0564 0.6603
Loa Loa (eye worm) hypothetical protein 0.0521 0.05 0.3961
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0178 0.0161 0.1958
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0161 0.016
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.0336 0.2662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.0846 0.8887
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0017 0.0017
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0006 0.0037
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.002 0.0204
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0821 0.0798 0.8385
Loa Loa (eye worm) hypothetical protein 0.0466 0.0446 0.353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Loa Loa (eye worm) hypothetical protein 0.0338 0.0319 0.2526
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0006 0.0037
Onchocerca volvulus 0.0055 0.0039 0.1143
Brugia malayi hypoxia-induced factor 1 0.0166 0.0149 0.1569
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0829 0.0806 0.8462
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0006 0.0005
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0017 0.5
Schistosoma mansoni hypothetical protein 0.0186 0.0169 0.1189
Echinococcus granulosus expressed protein 0.0413 0.0393 0.0393
Giardia lamblia Kinase, CMGC GSK 0.0056 0.004 0.0285
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0006 0.0005
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.043 0.041 0.4815
Entamoeba histolytica hypothetical protein 0.0178 0.0161 0.1641
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.002 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0161 0.1271
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0104 0.073
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0194 0.0177 0.0503
Giardia lamblia Phosphatidylinositol 4-kinase 0.0178 0.0161 0.1736
Trypanosoma brucei protein kinase, putative 0.0056 0.004 0.0412
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.004 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0815 0.0792 0.8319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.0118
Toxoplasma gondii hypothetical protein 0.0021 0.0006 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0178 0.0161 0.6236
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.0194 0.1372
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0869 0.0846 0.0846
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0014 0.009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0252 0.0234 0.0669
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0067 0.0051 0.0543
Plasmodium falciparum casein kinase II beta chain 0.004 0.0025 0.0782
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0017 0.0017
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0338 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0304 0.0286 0.2261
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0276 0.0258 0.0736
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0869 0.0846 0.2314
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0025 0.0024
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.004 0.0024 0.0167
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0178 0.0161 0.1844
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0859 0.0836 0.2402
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0859 0.0836 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0515 0.0495 0.5179
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.003 0.0014 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0109
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.0104 1
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0815 0.0792 0.2167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.078 0.8195
Brugia malayi Pre-SET motif family protein 0.0228 0.0211 0.2212
Echinococcus multilocularis serine protein kinase ATM 0.0482 0.0462 0.0462
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0017 0.0467
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0022
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0195
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0006 0.0005
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0975 0.0951 0.2735
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0104 0.1037
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.002 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0261 0.0243 0.2557
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.0104 1
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0025 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.0846 0.8887
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.0194 0.0554
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0006 0.0071
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0739 0.0717 0.7523
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0037
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0178 0.0161 0.1133
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.043 0.041 0.428
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0161 0.1271
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0466 0.0446 0.1279
Echinococcus multilocularis survival motor neuron protein 1 0.0521 0.05 0.05
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.0336 0.2662
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.0082 0.0082
Onchocerca volvulus 0.0111 0.0095 0.2804
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0042
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0014 0.0145
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0276 0.0258 0.2665
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0009 0.0071
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.003 0.0014 0.0014
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0025 0.0225
Entamoeba histolytica protein kinase rad3, putative 0.0466 0.0446 0.4656
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0043 0.0398
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0006 0.0037
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.009 0.0941
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0006 0.0005
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Brugia malayi Serotonin receptor 0.0515 0.0495 0.5207
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.004 0.1404
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.0104 0.6313
Loa Loa (eye worm) intermediate filament protein 0.003 0.0014 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0006 0.0044
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0042
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0178 0.0161 0.1133
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0038 0.0265
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.002 0.0137
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0006 0.0056
Echinococcus granulosus tumor protein p63 0.0373 0.0355 0.0354
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0053 0.0037 0.029
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0051 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.004 0.0368
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0849 0.0826 0.8674
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.003 0.0014 0.0097
Plasmodium vivax unspecified product 0.0151 0.0135 0.522
Loa Loa (eye worm) phosphatidylinositol 3 0.0815 0.0792 0.6273
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Schistosoma mansoni kinase 0.0109 0.0093 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.0486 0.5082
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0006 0.0011
Brugia malayi Casein kinase II, alpha chain 0.0151 0.0135 0.1412
Schistosoma mansoni hypothetical protein 0.0186 0.0169 0.1189
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0104 0.1037
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.004 0.0318
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0006 0.0042
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0006 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Echinococcus multilocularis high voltage activated calcium channel beta 0.0096 0.008 0.0079
Schistosoma mansoni intermediate filament proteins 0.003 0.0014 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0521 0.05 0.05
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0065 0.0065
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0355 0.0336 0.3535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.0801 0.8408
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1444 0.1415 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0288 0.027 0.2794
Entamoeba histolytica serine/threonine protein kinase, putative 0.0212 0.0194 0.1998
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0035
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.004 0.0368
Echinococcus granulosus lamin dm0 0.003 0.0014 0.0014
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0039 0.0271
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0017 0.0203
Toxoplasma gondii FATC domain-containing protein 0.0482 0.0462 0.5628
Leishmania major phosphatidylinositol kinase related protein, putative 0.0194 0.0177 0.0479
Trypanosoma cruzi target of rapamycin kinase 3 0.0849 0.0826 0.2374
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0276 0.0258 0.2665
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0515 0.0495 0.6035
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.048 0.046 0.4806
Echinococcus granulosus cyclin dependent kinase 19 0.0148 0.0131 0.0131
Loa Loa (eye worm) calcium channel 0.0035 0.002 0.0154
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0212 0.0194 0.1539
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0178 0.0161 0.1641
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Leishmania major hypothetical protein, unknown function 0.0178 0.0161 0.0435
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0482 0.0462 0.1325
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.043 0.041 0.428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0849 0.0826 0.8674
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0869 0.0846 0.8887
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0178 0.0161 0.6166
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0024 0.0167
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0006 0.0005
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.0095 0.0992
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0218 0.0201 0.2322
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0017 0.0206
Echinococcus multilocularis musashi 0.003 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0043 0.0398
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0006 0.0042
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.0492 0.5142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0042
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0006 0.0005
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0178 0.0161 0.6236
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0006 0.0056
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0067 0.0051 0.0051
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0719 0.0697 0.7325
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.0161 0.1687
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0276 0.0258 0.2038
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0024 0.0024
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0025 0.0202
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.0161 0.1687
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0006 0.0056
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0009 0.0071
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0869 0.0846 0.8887
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.002 0.0019
Echinococcus multilocularis Zinc finger, PHD finger 0.0276 0.0258 0.0257
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0104 0.073
Brugia malayi PXA domain containing protein 0.0023 0.0007 0.0072
Brugia malayi hypothetical protein 0.0521 0.05 0.5259
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0104 0.1037
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0276 0.0258 0.3138
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0017 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.0336 0.2375
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0975 0.0951 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0051 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Brugia malayi Protein kinase domain containing protein 0.002 0.0004 0.004
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0869 0.0846 0.0846
Entamoeba histolytica hypothetical protein 0.0178 0.0161 0.1641
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0025 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.0511 0.5348
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0008 0.0023
Brugia malayi PAS domain containing protein 0.0054 0.0038 0.0395
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.0082 0.0082
Brugia malayi PXA domain containing protein 0.0023 0.0007 0.0072
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0104 0.1037
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0975 0.0951 1
Brugia malayi hypothetical protein 0.0021 0.0006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0466 0.0446 0.4686
Echinococcus granulosus expressed conserved protein 0.009 0.0074 0.0074
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.043 0.041 0.1176
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0276 0.0258 0.0701
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0276 0.0258 1
Trypanosoma brucei Casein kinase II 0.0151 0.0135 0.1533
Giardia lamblia Casein kinase II beta chain 0.004 0.0025 0.0096
Entamoeba histolytica hypothetical protein 0.0821 0.0798 0.8385
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.0211 0.1666
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0037
Giardia lamblia Kinase, PLK 0.0212 0.0194 0.2144
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0212 0.0194 0.0194
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0716 0.0694 0.0694
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0007 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Entamoeba histolytica hypothetical protein 0.0482 0.0462 0.4826
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0043 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0482 0.0462 0.4826
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0025 0.0065
Echinococcus granulosus geminin 0.0186 0.0169 0.0168
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0046 0.003 0.026
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0025 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0332 0.0313 0.3578
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0 0.0000000040817
Brugia malayi intermediate filament protein 0.003 0.0014 0.0143
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0006 0.0005
Onchocerca volvulus 0.0111 0.0095 0.2804
Onchocerca volvulus 0.0106 0.009 0.2662
Echinococcus multilocularis protein kinase shaggy 0.0056 0.004 0.004
Brugia malayi Protein kinase domain containing protein 0.0148 0.0131 0.1376
Plasmodium vivax hypothetical protein 0.0178 0.0161 0.6236
Echinococcus granulosus single minded 2 0.004 0.0024 0.0024
Loa Loa (eye worm) phosphofructokinase 0.012 0.0104 0.0819
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.0104 0.0103
Onchocerca volvulus 0.0045 0.0029 0.0865
Loa Loa (eye worm) hypothetical protein 0.0111 0.0095 0.0748
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0276 0.0258 0.0257
Entamoeba histolytica hypothetical protein 0.0178 0.0161 0.1641
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0276 0.0258 0.0257
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0006 0.0044
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0338 0.0319 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.08 0.8407
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0008 0.0079
Schistosoma mansoni hypothetical protein 0.0057 0.0041 0.0286
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0006 0.0007
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0151 0.0135 0.1064
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0304 0.0286 0.0817
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Leishmania major hypothetical protein, conserved 0.3698 0.3649 1
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0025 0.0062
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.043 0.041 0.428
Loa Loa (eye worm) phosphatidylinositol 3 0.129 0.1263 1
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.004 0.0368
Loa Loa (eye worm) phosphatidylinositol kinase 0.0178 0.0161 0.1271
Echinococcus granulosus protein kinase shaggy 0.0056 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0003
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.002 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.0319 0.3317
Toxoplasma gondii hypothetical protein 0.0059 0.0043 0.0526
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0025 0.0725
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0006 0.0005
Echinococcus granulosus 6 phosphofructokinase 0.012 0.0104 0.0103
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.027 0.2794
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0014 0.0108
Echinococcus multilocularis geminin 0.0186 0.0169 0.0168
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0178 0.0161 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.009 0.0893
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0025 0.095
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0276 0.0258 0.0257
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0014 0.009
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1444 0.1415 0.1415
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0025 0.03
Schistosoma mansoni protein kinase 0.0151 0.0135 0.0949
Echinococcus multilocularis lamin 0.003 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.0801 0.8408
Echinococcus multilocularis expressed protein 0.0413 0.0393 0.0393
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0067 0.0051 0.0361
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0025 0.0065
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0154
Schistosoma mansoni ankyrin 23/unc44 0.0016 0 0.000000028841
Brugia malayi hypothetical protein 0.0021 0.0006 0.0056
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0017 0.0467
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.004 0.1561
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0869 0.0846 0.5975
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0355 0.0336 0.0336
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0466 0.0446 0.0446
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0178 0.0161 0.1641
Loa Loa (eye worm) hypothetical protein 0.018 0.0163 0.1292
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0104 0.1164
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0017 0.0641
Loa Loa (eye worm) Csnk2b protein 0.004 0.0025 0.0194
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0178 0.0161 0.1844
Schistosoma mansoni hypothetical protein 0.0106 0.009 0.0632
Onchocerca volvulus 0.026 0.0242 0.719
Loa Loa (eye worm) phosphatidylinositol 3 0.0252 0.0234 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 0.0846 0.8887
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0006 0.0037
Echinococcus granulosus bloom syndrome protein 0.0023 0.0008 0.0007
Onchocerca volvulus 0.003 0.0014 0.0403
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0469 0.0449 0.4718
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0276 0.0258 0.1818
Mycobacterium leprae conserved hypothetical protein 0.0178 0.0161 1
Leishmania major phosphatidylinositol kinase, putative 0.0178 0.0161 0.0435
Toxoplasma gondii hypothetical protein 0.0021 0.0006 0.0071
Entamoeba histolytica casein kinase, putative 0.0151 0.0135 0.1364
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0108
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.004 0.0318
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0104 0.1037
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.0446 0.4656
Brugia malayi Uncoordinated protein 44 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0198 0.0181 0.1853
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.0107 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0104 0.0819
Echinococcus multilocularis 0.0178 0.0161 0.016
Schistosoma mansoni lamin 0.003 0.0014 0.0096
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0195
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0859 0.0836 0.8784
Echinococcus granulosus lamin 0.003 0.0014 0.0014
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0869 0.0846 0.2314
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0046 0.003 0.026
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.002 0.0137
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0037
Onchocerca volvulus 0.004 0.0024 0.0705
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0482 0.0462 0.3262
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.0161 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0458 0.4781
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0975 0.0951 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0869 0.0846 0.8893
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0118
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.002 0.0019
Echinococcus multilocularis cyclin dependent kinase 19 0.0148 0.0131 0.0131
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0017 0.5
Trypanosoma brucei polo-like protein kinase 0.0212 0.0194 0.2246
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0096 0.0079 0.0079
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0009 0.0009
Schistosoma mansoni lamin 0.003 0.0014 0.0096
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.002 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0017 0.0017
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0515 0.0495 0.3921
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0194 0.1998
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0195
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0276 0.0258 0.2997
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0161 0.016
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0009 0.0095
Echinococcus multilocularis lamin dm0 0.003 0.0014 0.0014
Echinococcus granulosus high voltage activated calcium channel beta 0.0096 0.008 0.0079
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0104 0.1037
Leishmania major cytochrome p450-like protein 0.0021 0.0006 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0824 0.0801 0.8408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0561 0.0541 0.5658
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0849 0.0826 0.2259
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.0194 0.0554
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0849 0.0826 0.9761
Brugia malayi 6-phosphofructokinase 0.012 0.0104 0.1087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0178 0.0161 0.1687
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0029 0.0205
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0024 0.0024
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0869 0.0846 1
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0006 0.0218
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0482 0.0463 0.3266
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0178 0.0161 0.0457
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0006 0.0037
Leishmania major casein kinase II, putative 0.0151 0.0135 0.0363
Loa Loa (eye worm) hypothetical protein 0.0178 0.0161 0.1271
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0006 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0042
Brugia malayi hypothetical protein 0.004 0.0024 0.0249
Schistosoma mansoni survival motor neuron protein 0.0106 0.009 0.0632
Onchocerca volvulus 0.0178 0.0161 0.4772
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0 0.0000000040817
Onchocerca volvulus 0.0056 0.004 0.1193
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0803 0.078 0.9221
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0042
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0006 0.0005
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0276 0.0258 0.0736
Loa Loa (eye worm) RecQ helicase 0.0023 0.0008 0.0059
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) hypothetical protein 0.0111 0.0095 0.0747
Toxoplasma gondii CMGC kinase, CK2 family 0.0151 0.0135 0.1639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.078 0.8195
Echinococcus granulosus casein kinase ii subunit alpha 0.0151 0.0135 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0131 0.0924
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) phosphatidylinositol 3 0.0178 0.0161 0.1271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0024 0.0024
Echinococcus multilocularis casein kinase ii subunit alpha 0.0151 0.0135 0.0134
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0006 0.0005
Leishmania major phosphatidylinositol 3-kinase, putative 0.0803 0.078 0.2134
Echinococcus granulosus serine protein kinase ATM 0.0482 0.0462 0.0462
Brugia malayi Pre-SET motif family protein 0.0033 0.0017 0.0176
Schistosoma mansoni hypothetical protein 0.0178 0.0161 0.1133
Schistosoma mansoni fkbp-rapamycin associated protein 0.0466 0.0446 0.3148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.078 0.8195
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0482 0.0462 0.5429
Giardia lamblia GTOR 0.0869 0.0846 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0849 0.0826 0.8674
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0198 0.018 0.1894
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) hypothetical protein 0.0309 0.0291 0.2305
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0869 0.0846 0.2431
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0017 0.0203
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.004 0.0368
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0355 0.0336 0.0336
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.002 0.0019
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0006 0.0044
Brugia malayi FAT domain containing protein 0.0338 0.0319 0.3354
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0178 0.0161 0.016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) phosphatidylinositol 3 0.0869 0.0846 0.6698
Plasmodium vivax SET domain protein, putative 0.0033 0.0017 0.0651
Leishmania major phosphatidylinositol 3-kinase, putative 0.0276 0.0258 0.0701
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0118
Brugia malayi 6-phosphofructokinase 0.012 0.0104 0.1087
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0276 0.0258 0.3138
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0477 0.0458 0.4781
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0276 0.0258 0.2665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0849 0.0826 0.8674
Onchocerca volvulus 0.0178 0.0161 0.4772
Echinococcus granulosus intermediate filament protein 0.003 0.0014 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0014 0.0143
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0118
Loa Loa (eye worm) hypothetical protein 0.0376 0.0357 0.2825
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0178 0.0161 0.6166
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0466 0.0446 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.0491 0.5135
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0859 0.0836 0.5902
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0067 0.0051 0.0543
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0051 0.0485
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0096 0.008 0.056
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0025 0.0725
Trichomonas vaginalis set domain proteins, putative 0.026 0.0242 0.2499
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0161 0.016
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.003 0.0081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0482 0.0462 0.4855
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0536 0.0515 0.6067
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0896 0.0873 0.0872
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0198 0.018 0.1426
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0178 0.0161 0.016
Leishmania major ATP-dependent phosphofructokinase 0.012 0.0104 0.0278
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0082 0.0578
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0006 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0739 0.0717 0.7523
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0006 0.0007
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1444 0.1415 0.1415
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0716 0.0694 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.0243 0.1926
Plasmodium falciparum casein kinase 2, alpha subunit 0.0151 0.0135 0.5131
Loa Loa (eye worm) gastrulation defective protein 1 0.0144 0.0127 0.1007
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0276 0.0258 0.2706
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.043 0.041 0.428
Brugia malayi hypothetical protein 0.018 0.0163 0.1715
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0135 0.1364
Entamoeba histolytica hypothetical protein 0.004 0.0024 0.0195
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0178 0.0161 0.1958
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0178 0.0161 0.1133
Schistosoma mansoni voltage-gated cation channel 0.0035 0.002 0.0137
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0815 0.0792 0.9361
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0051 0.0142
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0104 0.1037
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0017 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.08 0.8407
Onchocerca volvulus 0.003 0.0014 0.0403
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.004 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0161 0.1641
Toxoplasma gondii ck2 beta subunit 0.004 0.0025 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.078 0.8195
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0017 0.0641
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.0486 0.5082
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0096 0.0079 0.0079
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0178 0.0161 0.6236
Brugia malayi phosphofructokinase 0.012 0.0104 0.1087
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.002 0.0019
Brugia malayi intracellular kinase 0.0056 0.004 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0859 0.0836 0.2402
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.003 0.0014 0.0014
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0009 0.0009
Brugia malayi hypothetical protein 0.0111 0.0095 0.0993
Toxoplasma gondii target of rapamycin (TOR), putative 0.0844 0.0821 1
Echinococcus multilocularis tumor protein p63 0.0373 0.0355 0.0354
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0869 0.0846 1
Schistosoma mansoni single-minded 0.0054 0.0038 0.0265
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0016 0.0015
Brugia malayi Cytochrome P450 family protein 0.0021 0.0006 0.0058
Onchocerca volvulus Serine\/threonine kinase homolog 0.0212 0.0194 0.5778
Giardia lamblia Hypothetical protein 0.0178 0.0161 0.1736
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0178 0.0161 0.6236
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0008 0.0023
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Echinococcus multilocularis expressed conserved protein 0.009 0.0074 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0161 0.1641
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0051 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0017 0.0118
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.0104 0.6313
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0025 0.0172
Brugia malayi Csnk2b protein 0.004 0.0025 0.0257
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0178 0.0161 0.0457
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0017 0.0133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0975 0.0951 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0104 0.0819
Giardia lamblia Kinase, CMGC GSK 0.0056 0.004 0.0285
Brugia malayi Cytochrome P450 family protein 0.0033 0.0017 0.0177
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0276 0.0258 1
Trypanosoma cruzi casein kinase II, putative 0.0151 0.0135 0.0382
Mycobacterium ulcerans putative regulatory protein 0.004 0.0024 0.1861
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0975 0.0951 0.2735
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0082 0.0578
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0014 0.009
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.004 0.011
Entamoeba histolytica protein kinase, putative 0.0056 0.004 0.0368
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0148 0.0131 0.1036
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0051 0.0485
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0044
Brugia malayi serine/threonine-protein kinase plk-2 0.0212 0.0194 0.2043
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0006 0.0056
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0178 0.0161 0.1958
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.002 0.0019
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0006 0.0011
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0178 0.0161 0.1641
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0104 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0009 0.0063
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.0486 0.5082
Brugia malayi Protein kinase domain containing protein 0.0355 0.0336 0.3535
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0975 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0823 0.08 0.8407
Brugia malayi Cytochrome P450 family protein 0.0021 0.0006 0.0058
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0067 0.0051 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.009 0.0893
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.004 0.0492
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.002 0.0019
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0006 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.0821 0.862
Leishmania major phosphatidylinositol 4-kinase, putative 0.0178 0.0161 0.0435
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0025 0.0202
Brugia malayi SH2 domain containing protein 0.0376 0.0357 0.375
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0025 0.0202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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