Detailed information for compound 886290

Basic information

Technical information
  • TDR Targets ID: 886290
  • Name: 4-(2-methoxyphenyl)-N-(2,4,4-trimethylpentan- 2-yl)piperidine-1-carboxamide
  • MW: 346.507 | Formula: C21H34N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C1CCN(CC1)C(=O)NC(CC(C)(C)C)(C)C
  • InChi: 1S/C21H34N2O2/c1-20(2,3)15-21(4,5)22-19(24)23-13-11-16(12-14-23)17-9-7-8-10-18(17)25-6/h7-10,16H,11-15H2,1-6H3,(H,22,24)
  • InChiKey: PHCWECSRMOZEJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-methoxyphenyl)-N-(1,1,3,3-tetramethylbutyl)piperidine-1-carboxamide
  • 4-(2-methoxyphenyl)-N-(1,1,3,3-tetramethylbutyl)-1-piperidinecarboxamide
  • Oprea1_805948

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0164 0.041 0.2072
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0023 0.0116
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0258 0.1015
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0258 0.1278
Echinococcus multilocularis survival motor neuron protein 1 0.0469 0.1248 0.1247
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0101 0.0394
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0001 0.000000010184
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0042 0.0042
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0014 0.0069
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0258 0.0898
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Brugia malayi bHLH-PAS transcription factor 0.0036 0.006 0.0307
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0061 0.0249
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0049 0.0168
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0717 0.1927 0.5598
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0085 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0139 0.0342 0.1347
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0128 0.0597
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0085 0.0193 0.0193
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Schistosoma mansoni hypothetical protein 0.0036 0.006 0.0206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0133 0.0326 0.0935
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0085 0.0193 0.4705
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0108 0.049
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0014 0.0069
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0342 0.0899 0.8443
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0085 0.0193 0.0193
Giardia lamblia Casein kinase II beta chain 0.0036 0.0061 0.019
Entamoeba histolytica hypothetical protein 0.0036 0.006 0.024
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0603 0.3082
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0401 0.1062 0.37
Echinococcus granulosus p2X purinoceptor 4 0.0455 0.1208 0.1208
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0035 0.0034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0401 0.1062 0.3078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0085 0.0193 0.7335
Onchocerca volvulus 0.0027 0.0034 0.0404
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0085 0.0193 0.0671
Toxoplasma gondii hypothetical protein 0.0019 0.0014 0.0145
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0051 0.0101 0.1007
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0061 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0899 0.4626
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0717 0.1927 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0392 0.1036 0.1036
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0014 0.0013
Onchocerca volvulus 0.0234 0.0604 0.7197
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0607 0.3148
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0061 0.1487
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0061 0.045
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0401 0.1062 0.2884
Brugia malayi phosphofructokinase 0.0108 0.0258 0.1338
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.2176 0.2175
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0191 0.0485 0.0484
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0099 0.0233 0.0664
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0101 0.0394
Schistosoma mansoni lamin 0.0027 0.0034 0.0118
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0085 0.0193 0.0938
Onchocerca volvulus 0.0085 0.0193 0.2299
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0049 0.0048
Toxoplasma gondii hypothetical protein 0.0053 0.0108 0.1076
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0085 0.0193 0.1934
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0342 0.1717
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0052
Schistosoma mansoni intermediate filament proteins 0.0027 0.0034 0.0118
Brugia malayi Csnk2b protein 0.0036 0.0061 0.0316
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0128 0.0127
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0224 0.1159
Plasmodium vivax unspecified product 0.0136 0.0335 0.8174
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0193 0.4705
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0014 0.0069
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0164 0.041 0.041
Leishmania major phosphatidylinositol 3-kinase, putative 0.0164 0.041 0.1105
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0128 0.0597
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0525 0.2068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0517 0.1379 0.7155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0899 0.4626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0401 0.1062 0.5479
Loa Loa (eye worm) hypothetical protein 0.0469 0.1248 0.4916
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.1003
Loa Loa (eye worm) hypothetical protein 0.0203 0.0518 0.2039
Brugia malayi Serine/threonine-protein kinase Pim-3 0.032 0.0839 0.4351
Schistosoma mansoni hypothetical protein 0.0085 0.0193 0.0671
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0485 0.1688
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0101 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0223 0.0574 0.2929
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0061 0.0164
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0146
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0049 0.0048
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0596 0.1596 0.827
Entamoeba histolytica hypothetical protein 0.0217 0.0558 0.2844
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0136 0.0335 0.1681
Echinococcus granulosus expressed conserved protein 0.0081 0.0184 0.0184
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0205 0.0712
Plasmodium vivax hypothetical protein 0.0085 0.0193 0.4705
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Toxoplasma gondii target of rapamycin (TOR), putative 0.0378 0.0999 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0236 0.0929
Onchocerca volvulus 0.0096 0.0224 0.2663
Loa Loa (eye worm) hypothetical protein 0.0338 0.089 0.3504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.1012 0.5217
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0121 0.0293 0.2665
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0049 0.0048
Leishmania major cytochrome p450-like protein 0.0019 0.0014 0.0025
Loa Loa (eye worm) CAMK/PIM protein kinase 0.032 0.0839 0.3303
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0061 0.0061
Brugia malayi M-phase phosphoprotein, mpp8 0.01 0.0236 0.1222
Entamoeba histolytica casein kinase, putative 0.0136 0.0335 0.1681
Onchocerca volvulus Serine\/threonine kinase homolog 0.0191 0.0485 0.5778
Schistosoma mansoni kinase 0.0098 0.0231 0.0804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Echinococcus granulosus high voltage activated calcium channel beta 0.0086 0.0198 0.0198
Brugia malayi PXA domain containing protein 0.002 0.0018 0.0089
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.106 0.2869 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0019 0.0097
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0401 0.1062 0.5479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0962 0.4955
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0101 0.01
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0392 0.1036 0.3003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0035 0.0179
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0258 0.0898
Loa Loa (eye worm) gastrulation defective protein 1 0.013 0.0317 0.1249
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.02 0.0509 0.1468
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0741 0.3844
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0139 0.0342 0.0342
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Onchocerca volvulus 0.0085 0.0193 0.2299
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0042 0.0416
Loa Loa (eye worm) calcium channel 0.0032 0.0049 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.1012 0.5217
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni P2X receptor subunit 0.0455 0.1208 0.4211
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0344 0.0904 0.4688
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0085 0.0193 0.1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Brugia malayi Pre-SET motif family protein 0.0029 0.0042 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.0618 0.3159
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0411 0.1089 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0191 0.0485 0.1397
Trypanosoma cruzi casein kinase II, putative 0.0136 0.0335 0.0962
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0134
Echinococcus multilocularis lamin dm0 0.0027 0.0034 0.0034
Giardia lamblia Kinase, CMGC CK2 0.0136 0.0335 0.2806
Loa Loa (eye worm) CAMK/PIM protein kinase 0.032 0.0839 0.3303
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4888
Echinococcus granulosus tumor protein p63 0.0336 0.0884 0.0884
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0085 0.0193 0.0193
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0717 0.1927 1
Toxoplasma gondii CMGC kinase, CK2 family 0.0136 0.0335 0.3357
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0164 0.041 0.2072
Leishmania major phosphatidylinositol 4-kinase, putative 0.0085 0.0193 0.0513
Brugia malayi serine/threonine-protein kinase plk-2 0.0191 0.0485 0.2514
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0061 0.1487
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0286 0.1423
Trypanosoma brucei protein kinase, putative 0.0051 0.0101 0.0824
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0352 0.0928 0.8722
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0052
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0128 0.1085
Schistosoma mansoni hypothetical protein 0.0081 0.0184 0.064
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0035 0.0111
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.006 0.0206
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0164 0.041 0.118
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0042 0.0165
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0061 0.0164
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0035 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0146
Loa Loa (eye worm) phosphatidylinositol 3 0.0085 0.0193 0.0759
Leishmania major casein kinase II, putative 0.0136 0.0335 0.0901
Echinococcus multilocularis expressed conserved protein 0.0081 0.0184 0.0184
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0128 0.0597
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0001 0.0001
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0061 0.1237
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0164 0.041 0.041
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0717 0.1927 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0332 0.0871 0.3036
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.032 0.0839 0.0838
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0007 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0042 0.0145
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0164 0.041 0.2072
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0205 0.0204
Entamoeba histolytica hypothetical protein 0.0085 0.0193 0.0938
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.006 0.0059
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0035 0.0111
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0042 0.0146
Echinococcus granulosus p2X purinoceptor 4 0.0455 0.1208 0.1208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0243 0.12
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Brugia malayi Cytochrome P450 family protein 0.0019 0.0014 0.0071
Schistosoma mansoni survival motor neuron protein 0.0096 0.0224 0.0778
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0085 0.0193 0.0548
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0055
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0327 0.1137
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0014 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0518 0.2635
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0061 0.0249
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0014 0.0145
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0023 0.0088
Brugia malayi Casein kinase II, alpha chain 0.0136 0.0335 0.1738
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0051 0.0101 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.1012 0.5217
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0014 0.0013
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0014 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0401 0.1062 0.5479
Echinococcus granulosus geminin 0.0167 0.0421 0.042
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0401 0.1062 0.5479
Loa Loa (eye worm) phosphatidylinositol 3 0.0085 0.0193 0.0759
Schistosoma mansoni hypothetical protein 0.0139 0.0342 0.1191
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0085 0.0193 0.1934
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0019 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0392 0.1036 0.5376
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4889
Echinococcus multilocularis p2X purinoceptor 4 0.0455 0.1208 0.1208
Brugia malayi SH2 domain containing protein 0.0338 0.089 0.4616
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0096 0.0334
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Mycobacterium ulcerans putative regulatory protein 0.0036 0.006 0.1861
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0392 0.1036 0.1036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0042 0.0145
Leishmania major phosphatidylinositol kinase related protein, putative 0.0099 0.0233 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.0618 0.3159
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0034 0.0134
Schistosoma mansoni single-minded 0.0048 0.0094 0.0326
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.106 0.2869 0.2869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0558 0.2844
Echinococcus granulosus protein kinase shaggy 0.0051 0.0101 0.01
Plasmodium vivax SET domain protein, putative 0.0029 0.0042 0.102
Loa Loa (eye worm) hypothetical protein 0.0514 0.1372 0.5406
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0284 0.0741 0.3802
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0258 0.0737
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0014 0.0069
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0046
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0101 0.0454
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0014 0.0341
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0258 0.1015
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0101 0.01
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0061 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0681 0.3488
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Loa Loa (eye worm) phosphatidylinositol 3 0.0939 0.2538 1
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0014 0.0057
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0086 0.0198 0.0689
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0136
Schistosoma mansoni fkbp-rapamycin associated protein 0.0203 0.0518 0.1803
Brugia malayi hypoxia-induced factor 1 0.015 0.0373 0.1931
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0133 0.0327 0.1285
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0014 0.0054
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0193 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0547 0.2788
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0164 0.041 0.2127
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0014 0.0046
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0014 0.0027
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0136 0.0335 0.8174
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0258 0.0258
Brugia malayi intracellular kinase 0.0051 0.0101 0.0519
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0042 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0258 0.1278
Brugia malayi Uncoordinated protein 44 0.0014 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0203 0.0518 0.1494
Echinococcus granulosus p2X purinoceptor 4 0.0455 0.1208 0.1208
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0049 0.0048
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0014 0.0013
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0632 0.1695 0.8788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0042 0.0145
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0101 0.0454
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0162 0.0162
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0284 0.0741 0.6937
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0014 0.0007
Echinococcus multilocularis high voltage activated calcium channel beta 0.0086 0.0198 0.0198
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Onchocerca volvulus 0.0041 0.0073 0.0866
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0164 0.041 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.366 1 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0086 0.0198 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0146
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0136 0.0335 0.1319
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0258 0.1278
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0085 0.0193 0.1934
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0139 0.0342 0.0342
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0075 0.032
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0738
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0085 0.0193 0.0938
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0014 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0023 0.0078
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0034 0.0134
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.032 0.0839 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0191 0.0485 0.1909
Trypanosoma brucei polo-like protein kinase 0.0191 0.0485 0.4492
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0514 0.1372 0.1372
Entamoeba histolytica hypothetical protein 0.0596 0.1596 0.827
Trypanosoma brucei Casein kinase II 0.0136 0.0335 0.3065
Brugia malayi hypothetical protein 0.0019 0.0014 0.0069
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0094 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4888
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0023 0.0078
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0085 0.0193 0.0548
Plasmodium vivax glycogen synthase kinase 3, putative 0.0051 0.0101 0.2443
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0128 0.0358
Entamoeba histolytica hypothetical protein 0.0085 0.0193 0.0938
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0164 0.041 0.1105
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0191 0.0485 0.1309
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0284 0.0741 0.3802
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0085 0.0193 0.1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0518 0.2686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0687 0.352
Schistosoma mansoni hypothetical protein 0.0096 0.0224 0.0778
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0717 0.1927 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0023 0.0078
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0085 0.0193 0.0671
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0049 0.0048
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0014 0.0013
Echinococcus granulosus lamin dm0 0.0027 0.0034 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0532 0.1419 0.7348
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Trypanosoma cruzi polo-like protein kinase, putative 0.0191 0.0485 0.1397
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0085 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0049 0.0096 0.0378
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0085 0.0193 0.4705
Giardia lamblia Phosphatidylinositol 4-kinase 0.0085 0.0193 0.1449
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0717 0.1927 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0042 0.0423
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0223 0.0574 0.5747
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0035 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4889
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0049 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Loa Loa (eye worm) hypothetical protein 0.0085 0.0193 0.0759
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0061 0.0249
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0086 0.0198 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Onchocerca volvulus 0.0049 0.0096 0.1143
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Mycobacterium leprae conserved hypothetical protein 0.0085 0.0193 0.7335
Loa Loa (eye worm) phosphatidylinositol kinase 0.0085 0.0193 0.0759
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0051 0.0101 0.0278
Echinococcus multilocularis cyclin dependent kinase 19 0.0133 0.0327 0.0326
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0205 0.0712
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0128 0.0358
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0023 0.0088
Leishmania major hypothetical protein, conserved 0.1352 0.367 1
Onchocerca volvulus 0.01 0.0236 0.2807
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0014 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0258 0.1278
Brugia malayi Pre-SET motif family protein 0.0206 0.0525 0.2725
Brugia malayi Cytochrome P450 family protein 0.0019 0.0014 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Echinococcus multilocularis serine protein kinase ATM 0.0217 0.0558 0.0557
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0392 0.1036 0.3003
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0049 0.0048
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.01 0.0236 0.0927
Leishmania major phosphatidylinositol 3-kinase, putative 0.0342 0.0899 0.2438
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0383 0.1012 0.2747
Echinococcus multilocularis geminin 0.0167 0.0421 0.042
Brugia malayi hypothetical protein 0.0036 0.006 0.0307
Echinococcus multilocularis Zinc finger, PHD finger 0.0164 0.041 0.041
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0164 0.041 0.118
Echinococcus granulosus expressed protein 0.0372 0.0981 0.098
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0014 0.0013
Brugia malayi Protein kinase domain containing protein 0.0018 0.001 0.0048
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0214 0.0547 0.2788
Onchocerca volvulus 0.01 0.0236 0.2807
Entamoeba histolytica hypothetical protein 0.0036 0.006 0.024
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0085 0.0193 0.455
Echinococcus multilocularis lamin 0.0027 0.0034 0.0034
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0014 0.0013
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0101 0.0564
Brugia malayi hypothetical protein 0.0162 0.0407 0.2111
Echinococcus multilocularis tumor protein p63 0.0336 0.0884 0.0884
Entamoeba histolytica hypothetical protein 0.0036 0.006 0.024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0027
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0085 0.0193 0.0671
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0193 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4889
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0014 0.0054
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0101 0.0348
Leishmania major phosphatidylinositol kinase, putative 0.0085 0.0193 0.0513
Toxoplasma gondii hypothetical protein 0.0019 0.0014 0.0145
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0075 0.0203
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0101 0.0454
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0035 0.0111
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0001 0.000000035502
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.106 0.2869 0.2869
Loa Loa (eye worm) hypothetical protein 0.0223 0.0574 0.226
Giardia lamblia GTOR 0.0401 0.1062 0.9745
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0014 0.0046
Entamoeba histolytica protein kinase, putative 0.0051 0.0101 0.0454
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0014 0.0013
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0203 0.0518 0.0517
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0164 0.041 0.2072
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0162 0.0162
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0607 0.2389
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0014 0.0052
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0101 0.0564
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.0128 0.0444
Schistosoma mansoni hypothetical protein 0.0051 0.0102 0.0352
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0043
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0061 0.0725
Loa Loa (eye worm) hypothetical protein 0.0032 0.0049 0.0191
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0014 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0899 0.4626
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0224 0.1101
Loa Loa (eye worm) hypothetical protein 0.0162 0.0407 0.1602
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0224 0.1101
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0383 0.1012 0.9523
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0128 0.0127
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0101 0.01
Loa Loa (eye worm) RecQ helicase 0.0021 0.0019 0.0074
Echinococcus multilocularis p2X purinoceptor 4 0.0455 0.1208 0.1208
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0085 0.0193 0.455
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0349 0.0917 0.4724
Brugia malayi hypothetical protein 0.0019 0.0014 0.0069
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0014 0.0046
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0128 0.0358
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Brugia malayi Death domain containing protein 0.0014 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0335 0.1681
Schistosoma mansoni hypothetical protein 0.0167 0.0421 0.1464
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0049 0.0048
Brugia malayi PXA domain containing protein 0.002 0.0018 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0085 0.0193 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0401 0.1062 0.5479
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0286 0.1423
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0019 0.0019
Brugia malayi 6-phosphofructokinase 0.0108 0.0258 0.1338
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0014 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.0352 0.0928 0.3655
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Entamoeba histolytica protein kinase rad3, putative 0.0203 0.0518 0.2635
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0205 0.0204
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0001 0.000000010184
Brugia malayi Protein kinase domain containing protein 0.032 0.0839 0.4351
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0738
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0164 0.041 0.041
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0401 0.1062 0.1061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0899 0.4626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0401 0.1062 0.551
Brugia malayi Serotonin receptor 0.0464 0.1235 0.6409
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.006 0.0059
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0329 0.0865 0.445
Loa Loa (eye worm) hypothetical protein 0.0247 0.064 0.2519
Schistosoma mansoni protein kinase 0.0136 0.0335 0.1167
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0164 0.041 0.1428
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0258 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0073 0.0253
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0164 0.041 0.1614
Echinococcus multilocularis p2X purinoceptor 4 0.0455 0.1208 0.1208
Schistosoma mansoni P2X receptor subunit 0.0455 0.1208 0.4211
Brugia malayi FAT domain containing protein 0.0139 0.0342 0.1774
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0061 0.0212
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0018 0.0067
Toxoplasma gondii ck2 beta subunit 0.0036 0.0061 0.0615
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0717 0.1927 0.5598
Schistosoma mansoni lamin 0.0027 0.0034 0.0118
Giardia lamblia Hypothetical protein 0.0085 0.0193 0.1449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.1012 0.5217
Brugia malayi hypothetical protein 0.01 0.0236 0.1223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0352 0.0928 0.478
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.5
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0178 0.0449 0.1769
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.032 0.0839 0.0838
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.1003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Echinococcus granulosus casein kinase ii subunit alpha 0.0136 0.0335 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0108 0.049
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0014 0.0046
Trypanosoma cruzi target of rapamycin kinase 3 0.0383 0.1012 0.2933
Brugia malayi Cytochrome P450 family protein 0.003 0.0042 0.0218
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0258 0.1278
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0164 0.041 1
Onchocerca volvulus 0.0036 0.006 0.0705
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0085 0.0193 0.4705
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0258 0.1278
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0164 0.041 0.4106
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0061 0.1237
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0205 0.0524 0.4609
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0049 0.0168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0217 0.0558 0.2893
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0014 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.02 0.0509 0.2004
Echinococcus granulosus survival motor neuron protein 1 0.0469 0.1248 0.1247
Schistosoma mansoni P2X receptor subunit 0.0455 0.1208 0.4211
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0164 0.041 0.3779
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0258 1
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0178 0.0449 0.2331
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0034 0.0176
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0075 0.032
Echinococcus granulosus lamin 0.0027 0.0034 0.0034
Echinococcus granulosus intermediate filament protein 0.0027 0.0034 0.0034
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0039 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0485 0.2463
Echinococcus granulosus bloom syndrome protein 0.0021 0.0019 0.0019
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0085 0.0193 0.1708
Echinococcus multilocularis musashi 0.0027 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0014 0.0054
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0258 0.0691
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0128 0.1085
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0061 0.0615
Schistosoma mansoni serine/threonine protein kinase 0.032 0.0839 0.2921
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0352 0.0928 0.2518
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0108 0.049
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0014 0.0013
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0085 0.0193 0.0938
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0191 0.0485 0.0484
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0085 0.0193 0.0938
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.0092 0.0359
Echinococcus granulosus single minded 2 0.0036 0.006 0.0059
Schistosoma mansoni hypothetical protein 0.0167 0.0421 0.1464
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0014 0.0069
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0514 0.1372 0.1372
Leishmania major hypothetical protein, unknown function 0.0085 0.0193 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4888
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0085 0.0193 0.0548
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0085 0.0193 0.1708
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0014 0.0013
Echinococcus granulosus serine protein kinase ATM 0.0217 0.0558 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Echinococcus multilocularis casein kinase ii subunit alpha 0.0136 0.0335 0.0335
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0284 0.0741 0.3802
Brugia malayi Protein kinase domain containing protein 0.0133 0.0327 0.1693
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0014 0.0013
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0284 0.0741 0.2144
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0258 0.1278
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0164 0.041 0.1428
Echinococcus multilocularis expressed protein 0.0372 0.0981 0.098
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0401 0.1062 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0999 0.515
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0203 0.0518 0.0517
Onchocerca volvulus 0.0027 0.0034 0.0404
Loa Loa (eye worm) phosphatidylinositol 3 0.0085 0.0193 0.0759
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0242 0.0624 0.5823
Giardia lamblia Kinase, PLK 0.0191 0.0485 0.4234
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0217 0.0558 0.161
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0401 0.1062 0.2884
Echinococcus granulosus cyclin dependent kinase 19 0.0133 0.0327 0.0326
Brugia malayi PAS domain containing protein 0.0048 0.0094 0.0486
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0014 0.0013
Brugia malayi 6-phosphofructokinase 0.0108 0.0258 0.1338
Echinococcus multilocularis 0.0085 0.0193 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.1267 0.3438 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0014 0.0013
Plasmodium falciparum glycogen synthase kinase 3 0.0051 0.0101 0.2221
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0128 0.0597
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0401 0.1062 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0061 0.0249
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0133 0.0326 0.1282
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0258 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0014 0.0027
Schistosoma mansoni P2X receptor subunit 0.0455 0.1208 0.4211
Entamoeba histolytica serine/threonine protein kinase, putative 0.0191 0.0485 0.2463
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0392 0.1036 0.361
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0258 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0049 0.0251
Entamoeba histolytica hypothetical protein 0.0036 0.006 0.024
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0042 0.0416
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0042 0.0042
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0401 0.1062 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0284 0.0741 0.3802
Toxoplasma gondii FATC domain-containing protein 0.0217 0.0558 0.5584
Loa Loa (eye worm) phosphatidylinositol 3 0.0401 0.1062 0.4183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.1012 0.5217
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0049 0.0168
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0023 0.0022
Brugia malayi hypothetical protein 0.0469 0.1248 0.6476
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0014 0.0013
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0049 0.0048
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0019 0.0029
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0373 0.1466
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0014 0.0013
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0085 0.0193 0.0548
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0401 0.1062 0.1061
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.0631 0.3226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0239 0.0618 0.3159
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0128 0.0597
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0052
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0061 0.024
Onchocerca volvulus 0.0051 0.0101 0.1193
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0258 0.2328
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0217 0.0558 0.1943
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0085 0.0193 0.1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0042 0.0416
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0532 0.1419 0.7348
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0014 0.0046
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0035 0.0034
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0258 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0164 0.041 0.4106
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0258 0.1015
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0164 0.041 0.2072
Brugia malayi intermediate filament protein 0.0027 0.0034 0.0176
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0217 0.0558 0.5188
Plasmodium falciparum casein kinase 2, alpha subunit 0.0136 0.0335 0.812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0962 0.4955
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.0949 0.4889

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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