Detailed information for compound 886342

Basic information

Technical information
  • TDR Targets ID: 886342
  • Name: 1-[2-[2-(2-methyl-1H-indol-3-yl)acetyl]pyrazo lidin-1-yl]propan-1-one
  • MW: 299.368 | Formula: C17H21N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCCN1C(=O)Cc1c(C)[nH]c2c1cccc2
  • InChi: 1S/C17H21N3O2/c1-3-16(21)19-9-6-10-20(19)17(22)11-14-12(2)18-15-8-5-4-7-13(14)15/h4-5,7-8,18H,3,6,9-11H2,1-2H3
  • InChiKey: USYZCWCUJAGQCC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[2-(2-methyl-1H-indol-3-yl)-1-oxoethyl]-1-pyrazolidinyl]propan-1-one
  • 1-[2-[2-(2-methyl-1H-indol-3-yl)ethanoyl]pyrazolidin-1-yl]propan-1-one
  • Oprea1_415388

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0316 0.0963 0.2609
Entamoeba histolytica hypothetical protein 0.0197 0.0583 0.2597
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0347 0.106 0.2872
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0016 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0705 0.22 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0077 0.0202 0.0574
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0056 0.0056
Onchocerca volvulus 0.005 0.0116 0.1193
Brugia malayi hypothetical protein 0.0019 0.0016 0.0069
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0365 0.1117 1
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0298 0.1023
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0071 0.0189
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0198 0.0587 0.1697
Giardia lamblia Casein kinase II beta chain 0.0036 0.0071 0.0193
Giardia lamblia Phosphatidylinositol 4-kinase 0.0077 0.0202 0.1301
Echinococcus granulosus protein kinase shaggy 0.005 0.0116 0.0115
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0048 0.5
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.0236 0.0235
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0183 0.0537 0.0536
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.2507 0.2507
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0069 0.0068
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0202 0.1935
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus multilocularis lamin 0.0026 0.004 0.0039
Echinococcus multilocularis protein kinase shaggy 0.005 0.0116 0.0115
Echinococcus granulosus expressed conserved protein 0.0081 0.0212 0.0211
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.0116 0.0351
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0156 0.0452 0.1555
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0016 0.0052
Giardia lamblia Kinase, CMGC CK2 0.0135 0.0386 0.2854
Brugia malayi Cytochrome P450 family protein 0.0019 0.0016 0.0072
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0056 0.0056
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0016 0.0052
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0077 0.0202 0.4466
Brugia malayi Casein kinase II, alpha chain 0.0135 0.0386 0.1754
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0071 0.0242
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0026 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0147
Brugia malayi PAS domain containing protein 0.0048 0.0109 0.0491
Echinococcus granulosus survival motor neuron protein 1 0.0466 0.1438 0.1437
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0156 0.0452 0.1998
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0298 0.129
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0298 0.0904
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0022 0.0098
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0386 0.1697
Schistosoma mansoni hypothetical protein 0.0077 0.0202 0.0614
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0146
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0069 0.0068
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0147 0.0147
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0202 0.0694
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0298 0.0297
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0705 0.22 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0048 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0069 0.0068
Entamoeba histolytica hypothetical protein 0.0036 0.0069 0.0242
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0316 0.0963 0.8599
Leishmania major phosphatidylinositol 4-kinase, putative 0.0077 0.0202 0.0535
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0336 0.1025 0.3529
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0147
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0202 0.1935
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0298 0.0795
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0056 0.0056
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.0116 0.0115
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0365 0.1117 0.34
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0365 0.1117 0.3247
Echinococcus granulosus lamin dm0 0.0026 0.004 0.0039
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0026 0.0026
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0077 0.0202 0.0574
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0356 0.1088 0.3161
Echinococcus granulosus serine protein kinase ATM 0.0197 0.0583 0.0582
Onchocerca volvulus 0.0036 0.0069 0.0705
Echinococcus granulosus tumor protein p63 0.0334 0.1019 0.1018
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0016 0.0015
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Toxoplasma gondii hypothetical protein 0.0019 0.0017 0.0159
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1046 0.3286 0.3285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4448
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.1088 0.4944
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.0236 0.0235
Schistosoma mansoni hypothetical protein 0.0166 0.0485 0.1473
Loa Loa (eye worm) hypothetical protein 0.0077 0.0202 0.0694
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0147 0.0414
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0135 0.0386 0.8544
Trichomonas vaginalis PIKK family atypical protein kinase 0.0219 0.0652 0.2915
Giardia lamblia Kinase, PLK 0.0189 0.0559 0.4307
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0114 0.0318 0.2736
Entamoeba histolytica hypothetical protein 0.0036 0.0069 0.0242
Brugia malayi phosphofructokinase 0.0107 0.0298 0.135
Onchocerca volvulus 0.0099 0.0272 0.2807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0056 0.0056
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.1048
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Leishmania major phosphatidylinositol kinase, putative 0.0077 0.0202 0.0535
Schistosoma mansoni lamin 0.0026 0.004 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.106 0.478
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0348 0.1522
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0116 0.0458
Onchocerca volvulus 0.0026 0.004 0.0404
Echinococcus granulosus lamin 0.0026 0.004 0.0039
Giardia lamblia GTOR 0.0365 0.1117 0.9018
Echinococcus multilocularis geminin 0.0166 0.0485 0.0484
Echinococcus multilocularis cyclin dependent kinase 19 0.0132 0.0376 0.0376
Loa Loa (eye worm) phosphatidylinositol 3 0.0198 0.0587 0.2018
Plasmodium vivax SET domain protein, putative 0.0029 0.0049 0.1067
Loa Loa (eye worm) hypothetical protein 0.0245 0.0737 0.2537
Loa Loa (eye worm) gastrulation defective protein 1 0.0129 0.0366 0.1258
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0317 0.0966 0.0966
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0365 0.1117 0.5079
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0147 0.0414
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0147 0.0603
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0202 0.0917
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0071 0.0725
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0156 0.0452 0.1374
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0086 0.0323
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0298 0.2553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.093 0.4184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4449
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Echinococcus multilocularis 0.0077 0.0202 0.0202
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0298 0.0852
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0705 0.22 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0202 0.0917
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.034 0.1037 0.4675
Brugia malayi hypothetical protein 0.0466 0.1438 0.6537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.1117 0.5045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.093 0.4184
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.1568 0.7128
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.0559 0.0558
Schistosoma mansoni protein kinase 0.0135 0.0386 0.1174
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.0773
Loa Loa (eye worm) calcium channel 0.0032 0.0056 0.0192
Entamoeba histolytica protein kinase, putative 0.005 0.0116 0.0458
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0197 0.0583 0.4516
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Brugia malayi Protein kinase domain containing protein 0.0132 0.0376 0.1709
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.0559 0.0558
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0016 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0049 0.0048
Entamoeba histolytica hypothetical protein 0.0585 0.1819 0.8254
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0146
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0183 0.0537 0.1551
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0202 0.0202
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0276 0.0833 0.3744
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Plasmodium vivax hypothetical protein 0.0077 0.0202 0.4466
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0086 0.0228 0.0227
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0236 0.0717
Brugia malayi SH2 domain containing protein 0.0336 0.1025 0.4659
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0202 0.0854
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0258 0.1111
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Trypanosoma brucei Casein kinase II 0.0135 0.0386 0.336
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0016 0.0046
Brugia malayi Cytochrome P450 family protein 0.0029 0.0049 0.022
Brugia malayi 6-phosphofructokinase 0.0107 0.0298 0.135
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0306 0.093 0.8293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0242 0.0725 0.3247
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0016 0.0046
Brugia malayi 6-phosphofructokinase 0.0107 0.0298 0.135
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0016 0.0046
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0132 0.0376 0.1294
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0086 0.0228 0.0693
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Onchocerca volvulus 0.0095 0.0258 0.2663
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0016 0.0015
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0071 0.007
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0077 0.0202 0.0854
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0376 0.1144
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0001 0.000000035725
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0016 0.0015
Toxoplasma gondii target of rapamycin (TOR), putative 0.0342 0.1045 1
Giardia lamblia Kinase, CMGC GSK 0.005 0.0116 0.0573
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0016 0.0069
Schistosoma mansoni hypothetical protein 0.0036 0.0069 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0559 0.1699
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0022 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0016 0.0046
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0077 0.0202 0.4466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.106 0.478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.1117 0.5045
Entamoeba histolytica casein kinase, putative 0.0135 0.0386 0.1697
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0365 0.1117 0.3029
Leishmania major phosphatidylinositol 3-kinase, putative 0.0156 0.0452 0.1216
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0202 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0084 0.0255
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0071 0.0189
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0401 0.1234 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.093 0.4184
Echinococcus multilocularis musashi 0.0026 0.004 0.0039
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0048 0.0458
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0056 0.0056
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0156 0.0452 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0017 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0966 0.294
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus granulosus single minded 2 0.0036 0.0069 0.0068
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0156 0.0452 0.0452
Entamoeba histolytica protein kinase rad3, putative 0.0183 0.0537 0.2386
Echinococcus granulosus cyclin dependent kinase 19 0.0132 0.0376 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0147 0.0603
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0077 0.0202 0.4296
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.004 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0026 0.0078
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0071 0.007
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0276 0.0833 0.742
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0123 0.0348 0.0347
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0276 0.0833 0.3787
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0705 0.22 0.6409
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus granulosus expressed protein 0.0369 0.113 0.1129
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0049 0.0048
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0056 0.0056
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0077 0.0202 0.4466
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0156 0.0452 0.1304
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0049 0.0048
Echinococcus multilocularis expressed conserved protein 0.0081 0.0212 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0026 0.0078
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.0559 0.5778
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0298 0.0904
Loa Loa (eye worm) hypothetical protein 0.012 0.0336 0.1156
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0016 0.0015
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.004 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0258 0.1111
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.0116 0.03
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Onchocerca volvulus 0.0077 0.0202 0.2087
Brugia malayi Uncoordinated protein 44 0.0014 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0699 0.2406
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.004 0.018
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.012 0.0336 0.0965
Leishmania major casein kinase II, putative 0.0135 0.0386 0.1037
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3154 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0202 0.0694
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0071 0.1295
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0365 0.1117 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0147 0.0414
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0086 0.0235
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.004 0.004
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0627 0.1953 0.887
Toxoplasma gondii hypothetical protein 0.0019 0.0017 0.0159
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0056 0.0056
Trypanosoma cruzi casein kinase II, putative 0.0135 0.0386 0.1112
Entamoeba histolytica hypothetical protein 0.0077 0.0202 0.0854
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0049 0.0466
Toxoplasma gondii ck2 beta subunit 0.0036 0.0071 0.0677
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0298 0.129
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0077 0.0202 0.1687
Loa Loa (eye worm) hypothetical protein 0.0161 0.0469 0.1613
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0504 0.1561 0.156
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0156 0.0452 1
Leishmania major cytochrome p450-like protein 0.0019 0.0016 0.0029
Loa Loa (eye worm) RecQ helicase 0.0021 0.0022 0.0074
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0276 0.0833 0.3744
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.004 0.0178
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0135
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0177 0.0518 0.1782
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1046 0.3286 0.3285
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0069 0.1861
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0236 0.0717
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.106 0.478
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.0595 0.2652
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0071 0.0493
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0147 0.119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0001 0.0001
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0056 0.0056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.0504 0.1561 0.5374
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.0116 0.0321
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0147
Toxoplasma gondii FATC domain-containing protein 0.0197 0.0583 0.5578
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0298 1
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0699 0.3177
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0071 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0219 0.0652 0.2915
Loa Loa (eye worm) phosphatidylinositol 3 0.0926 0.2904 1
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.0116 0.2324
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0298 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0016 0.0069
Trypanosoma brucei protein kinase, putative 0.005 0.0116 0.0903
Loa Loa (eye worm) hypothetical protein 0.0032 0.0056 0.0192
Brugia malayi Death domain containing protein 0.0014 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0156 0.0452 0.1998
Toxoplasma gondii hypothetical protein 0.0053 0.0124 0.1185
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0069 0.031
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0016 0.0069
Echinococcus multilocularis casein kinase ii subunit alpha 0.0135 0.0386 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0298 0.129
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.004 0.0135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0202 0.0694
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0077 0.0202 0.0574
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0071 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0202 0.4466
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.0116 0.1109
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0298 0.1023
Schistosoma mansoni hypothetical protein 0.0081 0.0212 0.0644
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0202 0.0202
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Onchocerca volvulus 0.0077 0.0202 0.2087
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0077 0.0202 0.0614
Schistosoma mansoni fkbp-rapamycin associated protein 0.0183 0.0537 0.1632
Onchocerca volvulus 0.004 0.0084 0.0866
Schistosoma mansoni hypothetical protein 0.0123 0.0348 0.1058
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0177 0.0518 0.2352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Trypanosoma cruzi target of rapamycin kinase 3 0.0347 0.106 0.3079
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0147
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.0559 0.2538
Brugia malayi PXA domain containing protein 0.002 0.002 0.0089
Schistosoma mansoni hypothetical protein 0.0051 0.0117 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Loa Loa (eye worm) hypothetical protein 0.0099 0.0272 0.0935
Brugia malayi hypothetical protein 0.0019 0.0016 0.0069
Leishmania major hypothetical protein, conserved 0.1168 0.3676 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0092 0.0248 0.0708
Brugia malayi Csnk2b protein 0.0036 0.0071 0.0319
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0156 0.0452 0.3957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4449
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0156 0.0452 0.1374
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0156 0.0452 0.0452
Brugia malayi PXA domain containing protein 0.002 0.002 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0316 0.0963 0.3315
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0258 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0124 0.0495
Plasmodium vivax unspecified product 0.0135 0.0386 0.8544
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Leishmania major phosphatidylinositol 3-kinase, putative 0.0306 0.093 0.2517
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0086 0.0323
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0071 0.1295
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.0559 0.1506
Leishmania major phosphatidylinositol kinase related protein, putative 0.0092 0.0248 0.0661
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0001 0.000000011736
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0016 0.0046
Echinococcus multilocularis lamin dm0 0.0026 0.004 0.0039
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0077 0.0202 0.1687
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0116 0.0458
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Brugia malayi Protein kinase domain containing protein 0.0018 0.0011 0.0049
Toxoplasma gondii CMGC kinase, CK2 family 0.0135 0.0386 0.3698
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.1819 0.8254
Entamoeba histolytica hypothetical protein 0.0077 0.0202 0.0854
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.002 0.0068
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0109 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4449
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0071 0.0725
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0202 0.0202
Echinococcus granulosus bloom syndrome protein 0.0021 0.0022 0.0021
Brugia malayi Cytochrome P450 family protein 0.0019 0.0016 0.0072
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0705 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0219 0.0652 0.2915
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.0559 0.1922
Onchocerca volvulus 0.0232 0.0696 0.7197
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0077 0.0202 0.0614
Schistosoma mansoni hypothetical protein 0.0166 0.0485 0.1473
Echinococcus multilocularis high voltage activated calcium channel beta 0.0086 0.0228 0.0228
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus granulosus geminin 0.0166 0.0485 0.0484
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Echinococcus granulosus casein kinase ii subunit alpha 0.0135 0.0386 0.0386
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0026 0.0089
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0016 0.0015
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0521 0.1615 0.7323
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Trypanosoma brucei polo-like protein kinase 0.0189 0.0559 0.4924
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0056 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0202 0.0854
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0317 0.0966 0.3326
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0022 0.0021
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0705 0.22 0.6409
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0183 0.0537 0.0536
Echinococcus multilocularis serine protein kinase ATM 0.0197 0.0583 0.0582
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0048 0.5
Entamoeba histolytica hypothetical protein 0.0077 0.0202 0.0854
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0123 0.0348 0.0347
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0202 0.0917
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0016 0.0015
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0048 0.0147
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0156 0.0452 0.1998
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.004 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0124 0.0495
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0317 0.0966 0.4391
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0016 0.0015
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0099 0.0272 0.0934
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0022 0.0029
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0356 0.1088 0.1087
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0298 0.129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0329 0.1002 0.4516
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.093 0.4184
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0365 0.1117 0.1117
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0317 0.0966 0.3326
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0276 0.0833 0.3744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0202 0.0854
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0056 0.0056
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0071 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.029 0.1256
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0156 0.0452 0.4327
Brugia malayi FAT domain containing protein 0.0123 0.0348 0.158
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0605 0.2083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0276 0.0833 0.3744
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0365 0.1117 0.3029
Brugia malayi Serotonin receptor 0.0461 0.1423 0.6468
Loa Loa (eye worm) phosphatidylinositol kinase 0.0077 0.0202 0.0694
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0116 0.0458
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0016 0.0069
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0016 0.0031
Brugia malayi hypothetical protein 0.0036 0.0069 0.031
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.004 0.0112
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0077 0.0202 0.0574
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0317 0.0966 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0187 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.106 0.478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0583 0.2597
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1046 0.3286 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0156 0.0452 0.1304
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0559 0.1615
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0116 0.0458
Schistosoma mansoni intermediate filament proteins 0.0026 0.004 0.0119
Onchocerca volvulus 0.0049 0.0111 0.1143
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0001 0.000000011736
Schistosoma mansoni single-minded 0.0048 0.0109 0.0328
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0056 0.0169
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0047 0.0106 0.0362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0197 0.0583 0.2648
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0017 0.0007
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0147 0.0447
Brugia malayi intracellular kinase 0.005 0.0116 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.1117 0.5045
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0017 0.0357
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.0116 0.2554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Echinococcus granulosus high voltage activated calcium channel beta 0.0086 0.0228 0.0228
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.004 0.004
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0077 0.0202 0.0614
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0016 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.0963 0.4338
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0086 0.0228 0.0227
Brugia malayi intermediate filament protein 0.0026 0.004 0.0178
Loa Loa (eye worm) hypothetical protein 0.0183 0.0537 0.1847
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0069 0.0207
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0026 0.0026
Echinococcus granulosus intermediate filament protein 0.0026 0.004 0.0039
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0071 0.0677
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0242 0.0725 0.3247
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0124 0.0495
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0017 0.006
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0202 0.1935
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0016 0.0046
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0116 0.0397
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Brugia malayi Protein kinase domain containing protein 0.0317 0.0966 0.4391
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0016 0.0015
Loa Loa (eye worm) intermediate filament protein 0.0026 0.004 0.0135
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0077 0.0202 0.0854
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0016 0.0046
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0298 0.129
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0016 0.0046
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0202 0.0202
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0056 0.0056
Brugia malayi hypothetical protein 0.0161 0.0469 0.213
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0202 0.6608
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0504 0.1561 0.156
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0016 0.0015
Echinococcus multilocularis Zinc finger, PHD finger 0.0156 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0329 0.1002 0.4516
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0219 0.0653 0.5779
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0055
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0298 1
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0695 0.3111
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0135 0.0386 0.1329
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0321 0.0976 0.4398
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0197 0.0583 0.1686
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0052
Leishmania major hypothetical protein, unknown function 0.0077 0.0202 0.0535
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0077 0.0202 0.4296
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Plasmodium falciparum casein kinase 2, alpha subunit 0.0135 0.0386 0.8499
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0365 0.1117 0.5045
Brugia malayi hypoxia-induced factor 1 0.0149 0.0429 0.1949
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0365 0.1117 0.5045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.004 0.0112
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0317 0.0966 0.0966
Schistosoma mansoni survival motor neuron protein 0.0095 0.0258 0.0783
Giardia lamblia Hypothetical protein 0.0077 0.0202 0.1301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Onchocerca volvulus 0.0026 0.004 0.0404
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0341 0.1041 0.4732
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0048 0.0458
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0276 0.0833 0.2418
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0156 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0028
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0016 0.0015
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0071 0.0177
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0705 0.22 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0298 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.0202 0.6608
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0056 0.0253
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0156 0.0452 0.4327
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0298 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Giardia lamblia Kinase, CMGC GSK 0.005 0.0116 0.0573
Loa Loa (eye worm) hypothetical protein 0.0123 0.0348 0.1197
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.0116 0.0115
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0048 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0016 0.0046
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0429 0.1476
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0298 0.129
Echinococcus multilocularis expressed protein 0.0369 0.113 0.1129
Schistosoma mansoni lamin 0.0026 0.004 0.0119
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0156 0.0452 0.1216
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0147 0.0147
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0193 0.0571 0.2541
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0559 0.1615
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.0773
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0071 0.0252
Loa Loa (eye worm) hypothetical protein 0.0466 0.1438 0.4951
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.0559 0.2486
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0016 0.0046
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0071 0.0252
Brugia malayi Pre-SET motif family protein 0.0029 0.0049 0.0219
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0016 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0017 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis survival motor neuron protein 1 0.0466 0.1438 0.1437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.1045 0.4713
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0056 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0193 0.0571 0.2541
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0356 0.1088 0.3161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0667 0.2982
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0147
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0016 0.0015
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0356 0.1088 0.1087
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0272 0.1233
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.0381
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0045 0.0045
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0187 0.0187
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0356 0.1088 0.3309
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0017 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0116 0.0397
Entamoeba histolytica hypothetical protein 0.0036 0.0069 0.0242
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0201 0.0595 0.2047
Brugia malayi Pre-SET motif family protein 0.0204 0.0605 0.275
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0156 0.0452 0.1998
Schistosoma mansoni hypothetical protein 0.0095 0.0258 0.0783
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0026 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0521 0.1615 0.7323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0146
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0147 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4448
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0323 0.0984 0.2992
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0129
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0156 0.0452 0.1998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.029 0.1256
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0386 0.1697
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0197 0.0583 0.1772
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0559 0.2486
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0026 0.0118
Echinococcus multilocularis tumor protein p63 0.0334 0.1019 0.1018
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0197 0.0583 0.5145
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0201 0.0595 0.5693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0537 0.2386
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0077 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.0987 0.4448
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0156 0.0452 0.2053
Brugia malayi hypothetical protein 0.0099 0.0272 0.1235
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0365 0.1117 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.026 0.1118
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0071 0.0213
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0016 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0365 0.1117 0.3847
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0298 0.129
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0298 0.1023
Entamoeba histolytica hypothetical protein 0.0036 0.0069 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0347 0.106 0.478
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0017 0.0159
Onchocerca volvulus 0.0099 0.0272 0.2807
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0016 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.1091 0.3429 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0147 0.119
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0147 0.0603
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0111 0.0336
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0071 0.0252
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0183 0.0537 0.2439
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0365 0.1117 0.3247
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0049 0.0166
Schistosoma mansoni kinase 0.0098 0.0266 0.0809
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0347 0.106 0.9477

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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