Detailed information for compound 912200

Basic information

Technical information
  • TDR Targets ID: 912200
  • Name: 2-(4-ethoxyphenyl)quinoxaline
  • MW: 250.295 | Formula: C16H14N2O
  • H donors: 0 H acceptors: 2 LogP: 3.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)c1cnc2c(n1)cccc2
  • InChi: 1S/C16H14N2O/c1-2-19-13-9-7-12(8-10-13)16-11-17-14-5-3-4-6-15(14)18-16/h3-11H,2H2,1H3
  • InChiKey: MMPGRBFWTQALIM-UHFFFAOYSA-N  


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Synonyms

  • 2-(4-Ethoxy-phenyl)-quinoxaline
  • ZINC00240436
  • SMR000432179
  • CBDivE_009949
  • STOCK3S-41174
  • MLS000768882

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Mus musculus heat shock factor 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica heat shock transcription factor, putative Get druggable targets OG5_129203 All targets in OG5_129203
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129203 All targets in OG5_129203
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae Heat Shock Factor HSF1 (YGL073W) RNA Pol II transcriptional activator Get druggable targets OG5_129203 All targets in OG5_129203
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Heat shock factor protein 2 homolog Get druggable targets OG5_129203 All targets in OG5_129203
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica heat shock transcription factor, putative Get druggable targets OG5_129203 All targets in OG5_129203
Brugia malayi HSF-type DNA-binding domain containing protein Get druggable targets OG5_129203 All targets in OG5_129203
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica heat shock transcription factor, putative Get druggable targets OG5_129203 All targets in OG5_129203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans similar to S. cerevisiae Heat Shock Factor HSF1 (YGL073W) RNA Pol II transcriptional activator Get druggable targets OG5_129203 All targets in OG5_129203
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.018 0.1684 0.1985
Brugia malayi Bromodomain containing protein 0.0084 0.0676 0.4016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0602 0.3576
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0337 0.0397
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0021 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0225 0.1337
Trichomonas vaginalis guanosine-diphosphatase, putative 0.0038 0.0206 0.6125
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.032 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0234 0.1391
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0375
Echinococcus multilocularis protein dispatched 1 0.0058 0.0412 0.0412
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.032 1
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0098 0.0934
Echinococcus multilocularis pyruvate kinase 0.0021 0.0021 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.032 0.0786
Echinococcus multilocularis pyruvate kinase 0.0021 0.0021 0.0021
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0098 0.0584
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.032 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0432 0.2569
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8481 0.8481
Brugia malayi PHD-finger family protein 0.0028 0.0095 0.0563
Loa Loa (eye worm) hypothetical protein 0.0079 0.0626 0.3721
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0169
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0602 0.3576
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0516 0.0609
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0602 0.071
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0004 0.0024
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.2453
Echinococcus multilocularis muscleblind protein 0.018 0.1684 0.1684
Echinococcus granulosus pyruvate kinase 0.004 0.0225 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0004 0.0004
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.0516 0.0609
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0499 0.0588
Mycobacterium ulcerans hypothetical protein 0.0029 0.0104 0.2011
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0225 0.1279
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1063 0.1253
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0258 0.0304
Trichomonas vaginalis adenosine diphosphatase, putative 0.0038 0.0206 0.6125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0432 0.2569
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.2453
Trypanosoma brucei pyruvate kinase 1 0.004 0.0225 0.7045
Echinococcus multilocularis pyruvate kinase 0.004 0.0225 0.0225
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0516 0.0516
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8481 1
Echinococcus multilocularis protein patched 0.0051 0.0337 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0104 0.2011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0104 0.2011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0337 0.0397
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0004 0.0024
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0028 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0617
Schistosoma mansoni guanosine-diphosphatase 0.0038 0.0206 0.0243
Echinococcus granulosus pyruvate kinase 0.0021 0.0021 0.0025
Brugia malayi Muscleblind-like protein 0.018 0.1684 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0021 0.0025
Leishmania major hypothetical protein, conserved 0.0049 0.032 0.619
Schistosoma mansoni ATP-diphosphohydrolase 1 0.0409 0.4068 0.4797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0337 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0206 0.6125
Trypanosoma brucei nucleoside diphosphatase, putative 0.0038 0.0206 0.6457
Loa Loa (eye worm) hypothetical protein 0.0045 0.0279 0.1654
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0104 0.2011
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.032 1
Brugia malayi hypothetical protein 0.0049 0.032 0.1898
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0409 0.4068 0.4068
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1575 0.1575
Brugia malayi RNA binding protein 0.0076 0.0602 0.3576
Entamoeba histolytica heat shock transcription factor, putative 0.012 0.1052 1
Schistosoma mansoni hypothetical protein 0.0043 0.0258 0.0304
Plasmodium vivax pyruvate kinase, putative 0.004 0.0225 0.7045
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0225 0.6682
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0104 0.2011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0104 0.2011
Echinococcus granulosus zinc finger protein 0.0022 0.0033 0.0039
Echinococcus granulosus pyruvate kinase 0.0021 0.0021 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0602 0.071
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0104 0.2011
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0225 0.1279
Echinococcus multilocularis pyruvate kinase 0.0032 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0169
Trichomonas vaginalis adenosine/guanosine diphosphatase, putative 0.0038 0.0206 0.6125
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0011 0.0064
Trichomonas vaginalis guanosine-diphosphatase, putative 0.0038 0.0206 0.6125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0316
Schistosoma mansoni zinc finger protein 0.0022 0.0033 0.0039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0004 0.0005
Schistosoma mansoni adenosine diphosphatase 0.0038 0.0206 0.0243
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.032 1
Trichomonas vaginalis guanosine-diphosphatase, putative 0.0038 0.0206 0.6125
Brugia malayi HSF-type DNA-binding domain containing protein 0.012 0.1052 0.625
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0432 0.2569
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0036 0.0036
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0104 0.2011
Echinococcus granulosus GPCR family 2 0.0019 0.0004 0.0005
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0225 0.1337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0337 0.0337
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0602 0.0602
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0337 0.0397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0004 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0104 0.0987
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0316
Brugia malayi hypothetical protein 0.0043 0.0258 0.1533
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0104 0.0617
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0225 0.7045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0036 0.0043
Echinococcus granulosus pyruvate kinase 0.004 0.0225 0.0265
Loa Loa (eye worm) hypothetical protein 0.0119 0.1043 0.6198
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0602 0.071
Plasmodium falciparum apyrase, putative 0.0409 0.4068 1
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0375
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0028 0.0552
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0004 0.0004
Schistosoma mansoni bromodomain containing protein 0.0071 0.054 0.0637
Echinococcus multilocularis zinc finger protein 0.0022 0.0033 0.0033
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.0516 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8481 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0021 0.0021
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein 0.0038 0.0206 0.6457
Loa Loa (eye worm) hypothetical protein 0.0051 0.0337 0.2001
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0225 0.7045
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0104 0.2011
Chlamydia trachomatis pyruvate kinase 0.004 0.0225 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0104 0.0617
Trypanosoma cruzi nucleoside phosphatase, putative 0.0038 0.0206 0.6457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0316
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Leishmania major pyruvate kinase 0.004 0.0225 0.4361
Loa Loa (eye worm) hypothetical protein 0.0028 0.0098 0.0584
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0004 0.0024
Schistosoma mansoni hypothetical protein 0.0041 0.0234 0.0276
Brugia malayi Bromodomain containing protein 0.0043 0.025 0.1486
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0004 0.0004
Schistosoma mansoni pyruvate kinase 0.004 0.0225 0.0265
Loa Loa (eye worm) hypothetical protein 0.012 0.1052 0.625
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0499 0.0499
Plasmodium falciparum pyruvate kinase 0.004 0.0225 0.0553
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.2453
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0427 0.2534
Echinococcus granulosus 3'partial|ectonucleoside triphosphate diphosphohydrolase 0.0038 0.0206 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0206 0.6125
Echinococcus granulosus ectonucleoside triphosphate diphosphohydrolase 0.0038 0.0206 0.0243
Toxoplasma gondii Nucleoside-diphosphatase 0.0038 0.0206 0.6457
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1043 0.6198
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0104 0.2011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.1786
Loa Loa (eye worm) pyruvate kinase 0.004 0.0225 0.1337
Toxoplasma gondii NTPase II 0.0038 0.0206 0.6457
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0104 0.2011
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0409 0.4068 0.4068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0337 0.0337
Brugia malayi hypothetical protein 0.0032 0.0137 0.0817
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0024
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0225 0.6682
Echinococcus granulosus expressed conserved protein 0.0112 0.0968 0.1142
Schistosoma mansoni pyruvate kinase 0.0021 0.0021 0.0025
Trypanosoma cruzi nucleoside phosphatase, putative 0.0038 0.0206 0.6457
Trichomonas vaginalis adenosine diphosphatase, putative 0.0038 0.0206 0.6125
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0225 0.1337
Loa Loa (eye worm) hypothetical protein 0.018 0.1684 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0067 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0016 0.0316
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0021 0.0658
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0021 0.0658
Plasmodium falciparum nucleoside-diphosphatase, putative 0.0038 0.0206 0.0507
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0104 0.0617
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0617
Brugia malayi Nucleoside-diphosphatase mig-23 0.0038 0.0206 0.1226
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0104 0.0987
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0258 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0104 0.2011
Trichomonas vaginalis adenosine diphosphatase, putative 0.0038 0.0206 0.6125
Schistosoma mansoni patched 1 0.0051 0.0337 0.0397
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0004 0.0004
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0225 0.4361
Mycobacterium ulcerans pyruvate kinase 0.004 0.0225 0.4361
Entamoeba histolytica heat shock transcription factor, putative 0.012 0.1052 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0225 0.1337
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0337 0.0337
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0258 0.0304
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0337 0.2001
Echinococcus granulosus tar DNA binding protein 0.0076 0.0602 0.071
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0337 0.1999
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0337 0.1999
Loa Loa (eye worm) pyruvate kinase 0.004 0.0225 0.1337
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.0516 1
Brugia malayi TAR-binding protein 0.0076 0.0602 0.3576
Echinococcus multilocularis muscleblind protein 1 0.018 0.1684 0.1684
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0038 0.0206 0.0206
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.032 0.0786
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0004 0.0004
Trypanosoma brucei nucleoside phosphatase, putative 0.0038 0.0206 0.6457
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0005
Echinococcus multilocularis pyruvate kinase 0.004 0.0225 0.0225
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.0516 0.3067
Giardia lamblia Pyruvate kinase 0.004 0.0225 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0104 0.0987
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0375
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0602 0.3576
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0375
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0028 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0602 0.071
Echinococcus multilocularis GPCR, family 2 0.0019 0.0004 0.0004
Echinococcus multilocularis expressed conserved protein 0.0112 0.0968 0.0968
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0225 0.7045
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0516 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0022
Schistosoma mansoni guanosine-diphosphatase 0.0038 0.0206 0.0243
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0516 1
Leishmania major ATP diphosphohydrolase 0.0038 0.0206 0.3997
Loa Loa (eye worm) hypothetical protein 0.0049 0.032 0.1898
Plasmodium vivax nucleoside-diphosphatase mig-23, putative 0.0038 0.0206 0.6457
Schistosoma mansoni hypothetical protein 0.0023 0.0045 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0337 1
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0617
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0004 0.0004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0223 0.0263
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0169
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0045 0.0269
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0004 0.0004
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1575 0.1857
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein 0.0038 0.0206 0.6457
Brugia malayi CHE-14 protein 0.0051 0.0337 0.2001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0337 0.0397
Schistosoma mansoni pyruvate kinase 0.004 0.0225 0.0265
Leishmania major nucleoside phosphatase, putative,guanosine diphosphatase, putative 0.0038 0.0206 0.3997
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0337 0.0397
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1043 0.123
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0004 0.0004
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1043 0.9917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0337 0.0397
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0067 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.1391
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.1491
Onchocerca volvulus Heat shock factor protein 2 homolog 0.012 0.1052 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0067 0.0079
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1043 0.1043
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0225 0.7045
Trichomonas vaginalis adenosine diphosphatase, putative 0.0038 0.0206 0.6125
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0004 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0432 0.2569
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.2453
Entamoeba histolytica heat shock transcription factor, putative 0.012 0.1052 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0602 0.071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0104 0.2011
Toxoplasma gondii GDA1/CD39 (nucleoside phosphatase) family protein 0.0038 0.0206 0.6457
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0004 0.0004
Echinococcus multilocularis ectonucleoside triphosphate diphosphohydrolase 0.0409 0.4068 0.4068
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0028 0.0892
Echinococcus granulosus ectonucleoside triphosphate diphosphohydrolase 0.0409 0.4068 0.4797
Giardia lamblia Pyruvate kinase 0.0021 0.0021 0.0934
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0223 0.0223
Leishmania major pyruvate kinase 0.004 0.0225 0.4361
Loa Loa (eye worm) hypothetical protein 0.018 0.1684 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0456 0.2711
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0225 0.1279
Loa Loa (eye worm) hypothetical protein 0.0038 0.0206 0.1226
Loa Loa (eye worm) RNA binding protein 0.0076 0.0602 0.3576

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 97.43 uM PUBCHEM_BIOASSAY: Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488968] ChEMBL. No reference
EC50 (functional) = 10.029 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
IC50 (functional) > 100 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1694 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 0.2617 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.5171 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 0.5171 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS assay for re-activators of p53 using a Luc reporter: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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