Detailed information for compound 977473

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.585 | Formula: C27H25N5OS
  • H donors: 2 H acceptors: 2 LogP: 5.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc2c(c1Nc1ccc3c(c1C)cc[nH]3)cc(s2)c1cccc(c1OC)CN(C)C
  • InChi: 1S/C27H25N5OS/c1-16-19-10-11-29-23(19)9-8-22(16)31-25-18(13-28)14-30-27-21(25)12-24(34-27)20-7-5-6-17(15-32(2)3)26(20)33-4/h5-12,14,29H,15H2,1-4H3,(H,30,31)
  • InChiKey: ZBGKNKIERAXNKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens protein kinase C, theta Starlite/ChEMBL References
Homo sapiens protein kinase C, delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus granulosus Diacylglycerol kinase theta 0.0018 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Echinococcus granulosus myotubularin protein 13 0.0018 0.0005 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0149 0.2249
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) LGC-31 protein 0.0043 0.0181 0.0392
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0149 0.0303
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0045 0.0195 0.0628
Schistosoma mansoni calcium-activated potassium channel 0.0462 0.3174 0.3174
Loa Loa (eye worm) carboxylesterase 0.0056 0.0274 0.0601
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0045 0.0195 0.3575
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0169 0.0331
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0181 0.0181
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0026 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0181 0.0392
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Plasmodium falciparum thioredoxin reductase 0.0038 0.0149 0.2346
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0908 0.0908
Echinococcus granulosus twik family of potassium channels 0.0023 0.0036 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.1419 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1608 0.3578
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0169 0.2656
Entamoeba histolytica hypothetical protein 0.0023 0.004 0.238
Schistosoma mansoni nAChR subunit 0.002 0.0016 0.0016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0034 0.0034
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0512 0.0512
Schistosoma mansoni protein kinase C 0.0018 0.0005 0.0005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0016 0.0016
Plasmodium vivax SET domain protein, putative 0.0093 0.0536 1
Schistosoma mansoni biogenic amine receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0023 0.0036 0.0068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0034 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0043 0.0181 0.0181
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0023 0.0036 0.0068
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0043 0.0181 0.0392
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0365
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Loa Loa (eye worm) hypothetical protein 0.0378 0.257 0.5726
Echinococcus granulosus raf serine:threonine protein kinase 0.002 0.0014 0.0014
Echinococcus granulosus PHD finger protein rhinoceros 0.009 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0181 0.0392
Echinococcus granulosus neuropeptide receptor 0.0022 0.0034 0.0034
Onchocerca volvulus 0.0022 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.0462 0.3174 0.7074
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0208
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0059 0.0059
Echinococcus multilocularis geminin 0.0329 0.2223 0.2223
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0169 0.2772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0034 0.0063
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0169 0.0331
Onchocerca volvulus 0.0023 0.0036 0.006
Schistosoma mansoni adenoreceptor 0.0022 0.0034 0.0034
Echinococcus granulosus nAChR subunit 0.0043 0.0181 0.0181
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0034 0.0034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0034 0.0063
Brugia malayi hypothetical protein 0.0041 0.0169 0.0365
Onchocerca volvulus 0.0022 0.0034 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0169 0.2656
Brugia malayi Bromodomain containing protein 0.0043 0.018 0.0391
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0026 0.0059 0.0059
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0034 0.0034
Onchocerca volvulus 0.0022 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0034 0.0034
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Onchocerca volvulus 0.0023 0.0036 0.006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0045 0.0195 0.0195
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0034 0.0063
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0043 0.0181 0.0181
Echinococcus granulosus unc 13 munc13 0.0018 0.0005 0.0005
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis phd:f box containing protein 0.0045 0.0195 0.0195
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0036 0.0036
Echinococcus granulosus zinc finger protein 0.0024 0.0043 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Echinococcus granulosus potassium channel subfamily K 0.0023 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0365
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0169 0.0169
Echinococcus granulosus sex peptide receptor 0.0022 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0014 0.0014
Onchocerca volvulus 0.002 0.0016 0.0021
Echinococcus multilocularis zinc finger protein 0.0024 0.0043 0.0043
Schistosoma mansoni neuropeptide receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) uncoordinated protein 58 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0034 0.0034
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0152 0.0152
Echinococcus granulosus lysine specific demethylase 5A 0.017 0.1089 0.1089
Loa Loa (eye worm) hypothetical protein 0.009 0.0515 0.1139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.011 0.0661 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0661 0.0661
Echinococcus granulosus serotonin receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0499 0.1245
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0059 0.0059
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0195 0.0424
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0034 0.0034
Echinococcus granulosus acetylcholinesterase 0.0331 0.2238 0.2238
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0181 0.0392
Leishmania major trypanothione reductase 0.0038 0.0149 0.0444
Brugia malayi Carboxylesterase family protein 0.0331 0.2238 0.4986
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0354 0.2397 0.2397
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Onchocerca volvulus 0.0023 0.0036 0.006
Brugia malayi Cation transporter family protein 0.0043 0.0181 0.0392
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.009 0.0515 0.0515
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0034 0.0063
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0009
Echinococcus granulosus glycine receptor subunit beta 0.0043 0.0181 0.0181
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.002 0.0016 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Echinococcus multilocularis JmjC domain containing protein 4 0.0045 0.0195 0.0195
Echinococcus granulosus g protein coupled receptor 0.0022 0.0034 0.0034
Schistosoma mansoni rac gtpase activating protein 0.0018 0.0005 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0169 0.0358
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0169 0.1062
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0034 0.0034
Plasmodium falciparum glutathione reductase 0.0038 0.0149 0.2346
Onchocerca volvulus 0.0049 0.0222 0.0424
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0059 0.0059
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0908 0.0908
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Echinococcus multilocularis microtubule associated protein 2 0.1419 1 1
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.015 0.015
Onchocerca volvulus 0.0022 0.0034 0.0055
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni amine GPCR 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni hypothetical protein 0.0329 0.2223 0.2223
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0169 0.0524
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0034 0.0034
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0005 0.0005
Schistosoma mansoni biogenic amine receptor 0.0022 0.0034 0.0034
Brugia malayi jmjC domain containing protein 0.0045 0.0195 0.0424
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0585 0.4046 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.006 0.0093
Onchocerca volvulus 0.0022 0.0034 0.0055
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0043 0.0181 0.0181
Onchocerca volvulus 0.0333 0.2253 0.4394
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.004 0.004
Echinococcus granulosus JmjC domain containing protein 4 0.0045 0.0195 0.0195
Brugia malayi RhoGAP domain containing protein 0.0023 0.0038 0.0072
Loa Loa (eye worm) hypothetical protein 0.0073 0.0393 0.0865
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0034 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0084 0.0968
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0206 0.0206
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.0189 0.0189
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) ACC-1 protein 0.0043 0.0181 0.0392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1052 0.2338
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) carboxylesterase 0.0331 0.2238 0.4986
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0034 0.0034
Schistosoma mansoni phd/f-box containing protein 0.0045 0.0195 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0189 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis unc 13 (munc13) 0.0018 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Brugia malayi jmjC domain containing protein 0.017 0.1089 0.242
Onchocerca volvulus 0.0056 0.0274 0.0526
Brugia malayi Cation transporter family protein 0.0043 0.0181 0.0392
Schistosoma mansoni serine/threonine kinase 0.0026 0.0059 0.0059
Onchocerca volvulus 0.0041 0.0169 0.032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0191 0.0305
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0056 0.0274 0.0642
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Echinococcus multilocularis neuroligin 0.0056 0.0274 0.0274
Giardia lamblia PHD finger protein 15 0.009 0.0515 1
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0056 0.0274 0.0274
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0026 0.0059 0.012
Onchocerca volvulus 0.0043 0.0181 0.0343
Brugia malayi excitatory GABA receptor EXP-1A 0.0043 0.0181 0.0392
Schistosoma mansoni protein phosphatase 2C 0.0045 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0331 0.2238 0.4986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0191 0.0305
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0023 0.0036 0.0068
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0034 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0499 0.1245
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0181 0.0392
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0169 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0295 0.0295
Echinococcus granulosus acetylcholinesterase 0.0331 0.2238 0.2238
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0536 0.0536
Echinococcus granulosus jumonji domain containing protein 0.0125 0.0766 0.0766
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0543 0.3752 1
Schistosoma mansoni calcium-activated potassium channel 0.044 0.3013 0.3013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0023 0.0038 0.0072
Brugia malayi C1-like domain containing protein 0.0019 0.0009 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0568 0.1432
Schistosoma mansoni amine GPCR 0.0022 0.0034 0.0034
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0084 0.0191
Onchocerca volvulus 0.0056 0.0274 0.0526
Brugia malayi hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni alpha-glucosidase 0.0142 0.0888 0.0888
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0034 0.0034
Brugia malayi Carboxylesterase family protein 0.0331 0.2238 0.4986
Echinococcus multilocularis serotonin receptor 0.0141 0.0883 0.0883
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0206 0.0447
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0169 0.2772
Plasmodium falciparum phd finger protein, putative 0.009 0.0515 1
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0043 0.0181 0.0392
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0034 0.0063
Brugia malayi PHD-finger family protein 0.009 0.0515 0.1139
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Brugia malayi Carboxylesterase family protein 0.0056 0.0274 0.0601
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0136 0.0197
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0862 0.0862
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0043 0.0181 0.0181
Echinococcus multilocularis small conductance calcium activated potassium 0.0462 0.3174 0.3174
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0043 0.0181 0.0392
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) acetyltransferase 0.0145 0.0908 0.2015
Mycobacterium ulcerans oxidoreductase 0.0041 0.0169 0.0331
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0034 0.0063
Onchocerca volvulus 0.0043 0.0181 0.0343
Schistosoma mansoni histamine h1 receptor 0.0022 0.0034 0.0034
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0908 0.2015
Loa Loa (eye worm) hypothetical protein 0.0359 0.2437 0.543
Loa Loa (eye worm) hypothetical protein 0.0141 0.0883 0.1959
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus calcium activated potassium channel variant 0.0023 0.0036 0.0036
Brugia malayi Dopamine receptor protein 1 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Onchocerca volvulus 0.0022 0.0034 0.0055
Schistosoma mansoni protein kinase C mu 0.0018 0.0005 0.0005
Mycobacterium tuberculosis Probable reductase 0.0087 0.0499 0.1245
Brugia malayi putative neuropeptide receptor 0.0022 0.0034 0.0063
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0034 0.0034
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0181 0.0392
Echinococcus multilocularis PHD finger protein rhinoceros 0.009 0.0515 0.0515
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0034 0.0034
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0056 0.0274 0.0274
Echinococcus granulosus biogenic amine 5HT receptor 0.0141 0.0883 0.0883
Onchocerca volvulus 0.0022 0.0034 0.0055
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0043 0.0181 0.0181
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0036 0.0036
Onchocerca volvulus 0.0093 0.0536 0.1038
Onchocerca volvulus 0.0023 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Onchocerca volvulus Putative nachr subunit 0.0043 0.0181 0.0343
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0274 0.0274
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0222 0.0484
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Echinococcus multilocularis protein kinase c iota type 0.0044 0.0189 0.0189
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0023 0.0036 0.2115
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.0189 0.0189
Schistosoma mansoni zinc finger protein 0.0024 0.0043 0.0043
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Onchocerca volvulus 0.0022 0.0034 0.0055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0034 0.0034
Echinococcus granulosus allatostatin A receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Schistosoma mansoni amine GPCR 0.0022 0.0034 0.0034
Toxoplasma gondii AGC kinase 0.0026 0.0059 0.1016
Echinococcus granulosus small conductance calcium activated potassium 0.0462 0.3174 0.3174
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0023 0.0036 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0295 0.5452
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0034 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0034 0.0034
Schistosoma mansoni inositol monophosphatase 0.0039 0.015 0.015
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0023 0.004 0.004
Brugia malayi jmjC domain containing protein 0.0045 0.0195 0.0424
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0138 0.0138
Onchocerca volvulus 0.0023 0.0036 0.006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0169 0.2772
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0034 0.0063
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0043 0.0181 0.0392
Brugia malayi Pre-SET motif family protein 0.0646 0.4484 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0136 0.0293
Echinococcus multilocularis serotonin receptor 0.0141 0.0883 0.0883
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0018 0.0005 0.0005
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0026 0.0059 0.012
Echinococcus granulosus NDR protein kinase 0.0026 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Echinococcus granulosus protein kinase c eta type 0.0018 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Echinococcus granulosus protein kinase C gamma type 0.0026 0.0059 0.0059
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Echinococcus granulosus orexin receptor type 2 0.0022 0.0034 0.0034
Loa Loa (eye worm) glutathione reductase 0.0038 0.0149 0.032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0169 0.308
Echinococcus granulosus para nitrobenzyl esterase 0.0056 0.0274 0.0274
Brugia malayi Hr1 repeat family protein 0.0026 0.0059 0.012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0365
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni amine GPCR 0.0022 0.0034 0.0034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus BC026374 protein S09 family 0.0056 0.0274 0.0274
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0123 0.0262
Schistosoma mansoni jumonji/arid domain-containing protein 0.017 0.1089 0.1089
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1576 0.1576
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0034 0.0034
Trypanosoma brucei trypanothione reductase 0.0038 0.0149 0.0444
Onchocerca volvulus 0.0022 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Onchocerca volvulus 0.0022 0.0034 0.0055
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0136 0.0197
Echinococcus granulosus carboxylesterase 5A 0.0331 0.2238 0.2238
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni vav2 0.0023 0.0038 0.0038
Trypanosoma brucei glucosidase, putative 0.0037 0.0136 0.0396
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0034 0.0034
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.0169 0.308
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0515 0.9607
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0208 0.1359 0.3023
Brugia malayi Bromodomain containing protein 0.008 0.0449 0.099
Echinococcus granulosus Rac GTPase activating protein 1 0.0018 0.0005 0.0005
Echinococcus granulosus g protein coupled receptor 0.0022 0.0034 0.0034
Schistosoma mansoni diacylglycerol kinase theta 0.0018 0.0005 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.006 0.1022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0138 0.0138
Schistosoma mansoni opsin-like receptor 0.0022 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.0045 0.0195 0.0628
Trichomonas vaginalis set domain proteins, putative 0.0735 0.5121 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0646 0.4484 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0023 0.0036 0.0068
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0043 0.0181 0.0392
Echinococcus multilocularis nAChR subunit 0.0023 0.004 0.004
Mycobacterium ulcerans dehydrogenase 0.0041 0.0169 0.0331
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Schistosoma mansoni acetylcholine receptor-related 0.002 0.0016 0.0016
Brugia malayi sulfakinin receptor protein 0.0022 0.0034 0.0063
Onchocerca volvulus 0.0023 0.0036 0.006
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0034 0.0063
Onchocerca volvulus 0.0043 0.0181 0.0343
Schistosoma mansoni alpha glucosidase 0.0037 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Onchocerca volvulus 0.0043 0.0181 0.0343
Onchocerca volvulus 0.0095 0.0556 0.1076
Brugia malayi SWIRM domain containing protein 0.0041 0.0169 0.0365
Loa Loa (eye worm) hypothetical protein 0.0193 0.1252 0.2784
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.006 0.0493
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0169 0.0169
Brugia malayi jmjC domain containing protein 0.0354 0.2397 0.534
Brugia malayi Carboxylesterase family protein 0.0056 0.0274 0.0601
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.004 0.0077
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0034 0.0034
Echinococcus granulosus glycine receptor subunit beta 0.0043 0.0181 0.0181
Onchocerca volvulus Alhambra homolog 0.009 0.0515 0.0997
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.257 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Echinococcus multilocularis lysine specific demethylase 5A 0.0168 0.1075 0.1075
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0121 0.023
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0043 0.0181 0.0181
Echinococcus granulosus glycine receptor subunit alpha 1 0.0043 0.0181 0.0181
Echinococcus granulosus N chimaerin 0.0023 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0352 0.2383 0.5309
Onchocerca volvulus 0.0022 0.0034 0.0055
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1052 0.1052
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0034 0.0034
Loa Loa (eye worm) AGC/NDR protein kinase 0.0026 0.0059 0.012
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.015 0.015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0034 0.0034
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.004 0.004
Toxoplasma gondii ion channel protein 0.0023 0.0036 0.0577
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0023 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0034 0.0034
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni hypothetical protein 0.0462 0.3174 0.3174
Brugia malayi larval opioid receptor 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni opsin-like receptor 0.0022 0.0034 0.0034
Echinococcus granulosus serine:threonine protein kinase N2 0.0026 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0045 0.0195 0.0424
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0034 0.0034
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0026 0.0059 0.0059
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus multilocularis para nitrobenzyl esterase 0.0056 0.0274 0.0274
Brugia malayi Dopamine receptor protein 2 0.0022 0.0034 0.0063
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0036 0.0036
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0195 0.0628
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0206
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0045 0.0195 0.0424
Loa Loa (eye worm) hypothetical protein 0.011 0.0661 0.1464
Brugia malayi Thioredoxin reductase 0.0038 0.0149 0.032
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.0084 0.101
Leishmania major UDP-galactopyranose mutase 0.0041 0.0169 0.0524
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Brugia malayi MH2 domain containing protein 0.0243 0.1608 0.3578
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0034 0.0034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0333 0.2253 0.5019
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0043 0.0181 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0136 0.0197
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0036 0.0036
Brugia malayi p70 ribosomal S6 kinase beta 0.0026 0.0059 0.012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0034 0.0034
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0019 0.0009 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0043 0.0181 0.0181
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0169 0.0169
Echinococcus multilocularis myotubularin protein 13 0.0018 0.0005 0.0005
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0585 0.4046 1
Brugia malayi glutathione reductase 0.0038 0.0149 0.032
Brugia malayi RE15519p 0.0022 0.0034 0.0063
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0023 0.0036 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.011 0.0661 0.0661
Brugia malayi jmjC domain containing protein 0.0045 0.0195 0.0424
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0023 0.0038 0.0038
Echinococcus multilocularis potassium channel subfamily K 0.0023 0.0036 0.0036
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0034 0.0034
Schistosoma mansoni acetylcholinesterase 0.0056 0.0274 0.0274
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0043 0.0181 0.0181
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0026 0.0059 0.0059
Echinococcus granulosus glycine receptor subunit alpha 1 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1052 0.1052
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0462
Plasmodium falciparum JmjC domain-containing protein, putative 0.0045 0.0195 0.332
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.004 0.0077
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0034 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0337 0.0337
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0018 0.0005 0.0005
Loa Loa (eye worm) TWK-28 protein 0.0023 0.0036 0.0068
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0136 0.0197
Schistosoma mansoni jumonji/arid domain-containing protein 0.017 0.1089 0.1089
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0034 0.0034
Brugia malayi G protein-coupled receptor 0.0022 0.0034 0.0063
Echinococcus granulosus neuroligin 0.0056 0.0274 0.0274
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0023 0.0036 0.0068
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.006 0.0472
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.009 0.0515 0.0515
Echinococcus granulosus g protein coupled receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0232 0.1529 0.3402
Loa Loa (eye worm) hypothetical protein 0.0238 0.1576 0.3508
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0047 0.0209 0.0209
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0365
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0295 0.0295
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.004 0.004
Schistosoma mansoni neuropeptide receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Brugia malayi Pre-SET motif family protein 0.0093 0.0536 0.1185
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0331 0.2238 0.4986
Schistosoma mansoni jumonji domain containing protein 0.0293 0.1966 0.1966
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.002 0.0016 0.0024
Echinococcus multilocularis nAChR subunit 0.0043 0.0181 0.0181
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.0181 0.0392
Brugia malayi jmjC domain containing protein 0.0045 0.0195 0.0424
Echinococcus granulosus jumonji domain containing 1A 0.0045 0.0195 0.0195
Onchocerca volvulus 0.0735 0.5121 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0331 0.2238 0.4986
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0034 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0043 0.0181 0.0181
Schistosoma mansoni myosin xvIII 0.0022 0.0034 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0185 0.1197 0.2661
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.002 0.0016 0.0016
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0136 0.0396
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0568 1
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.0059 0.012
Entamoeba histolytica protein kinase, putative 0.0026 0.0059 0.3722
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0181 0.0392
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0034 0.0034
Echinococcus multilocularis jumonji domain containing 1A 0.0045 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0365
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0661 0.0661
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.015 0.0225
Schistosoma mansoni amine GPCR 0.0022 0.0034 0.0034
Schistosoma mansoni amine oxidase 0.0041 0.0169 0.0169
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0026 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0034 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0568 0.1432
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0195 0.0424
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0084 0.149
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.015 0.0225
Entamoeba histolytica protein kinase, putative 0.0026 0.0059 0.3722
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0043 0.0181 0.0181
Entamoeba histolytica protein kinase, putative 0.0026 0.0059 0.3722
Echinococcus multilocularis sex peptide receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0026 0.0059 0.012
Brugia malayi Carboxylesterase family protein 0.0056 0.0274 0.0601
Onchocerca volvulus 0.0022 0.0034 0.0055
Brugia malayi hypothetical protein 0.0023 0.0036 0.0068
Leishmania major hypothetical protein, conserved 0.0026 0.006 0.0093
Loa Loa (eye worm) hypothetical protein 0.017 0.1086 0.2413
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0488 0.3358 0.7486
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0043 0.0181 0.0181
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0337 0.0337
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.006 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0536 1
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0045 0.0198 0.043
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0043 0.0181 0.0392
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0295 0.0645
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0034 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0189 0.0189
Schistosoma mansoni bromodomain containing protein 0.0068 0.0363 0.0363
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Brugia malayi Serotonin receptor 0.0022 0.0034 0.0063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0499 0.8443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0206 0.0206
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.015 0.273
Brugia malayi hypothetical protein 0.002 0.0016 0.0024
Onchocerca volvulus 0.0023 0.004 0.0067
Mycobacterium tuberculosis Carboxylesterase LipT 0.0056 0.0274 0.0642
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0045 0.0195 0.3575
Echinococcus granulosus geminin 0.0329 0.2223 0.2223
Onchocerca volvulus 0.002 0.0016 0.0021
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0023 0.0036 0.0068
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.004 0.0077
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0195 0.0195
Brugia malayi Inositol-1 0.0039 0.015 0.0324
Brugia malayi Serotonin receptor 0.0022 0.0034 0.0063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.004 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Echinococcus multilocularis glycine receptor subunit beta 0.0043 0.0181 0.0181
Schistosoma mansoni biogenic amine receptor 0.0022 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0136 0.0197
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0023 0.0036 0.0036
Echinococcus multilocularis jumonji domain containing protein 0.0125 0.0766 0.0766
Loa Loa (eye worm) GABA receptor subunit 0.0023 0.004 0.0077
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0043 0.0181 0.0392
Brugia malayi G-protein coupled receptor 0.0022 0.0034 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Echinococcus multilocularis acetylcholinesterase 0.0331 0.2238 0.2238
Brugia malayi hypothetical protein 0.0026 0.006 0.0121
Brugia malayi hypothetical protein 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni diacylglycerol kinase theta 0.0018 0.0005 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0295 0.1021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.006 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0536 0.0536
Echinococcus granulosus glycine receptor subunit alpha 1 0.0043 0.0181 0.0181
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0034 0.0034
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Echinococcus granulosus twik family of potassium channels 0.0023 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0206 0.0206
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Echinococcus granulosus protein kinase c iota type 0.0044 0.0189 0.0189
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0295 0.0295
Brugia malayi Protein kinase domain containing protein 0.0026 0.0059 0.012
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1052 0.1052
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0136 0.0197
Schistosoma mansoni survival motor neuron protein 0.0049 0.0222 0.0222
Onchocerca volvulus 0.0056 0.0274 0.0526
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.257 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0169 0.0365
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0121
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0034 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0568 0.1432
Brugia malayi protein kinase C II. 0.0044 0.0189 0.0411
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.004 0.004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0034 0.0063
Schistosoma mansoni atypical protein kinase C 0.0044 0.0189 0.0189
Plasmodium vivax JmjC domain containing protein 0.0045 0.0195 0.3181
Mycobacterium ulcerans carboxylesterase, LipT 0.0056 0.0274 0.0595
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0023 0.0038 0.0038
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0025 0.0055 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0034 0.0063
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0026 0.0059 0.0059
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0046
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0189 0.0189
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0149 0.2355
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0038 0.0072
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0034 0.0034
Brugia malayi G-protein coupled receptor 0.0022 0.0034 0.0063
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0034 0.0063
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0016 0.0024
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0043 0.0181 0.0392
Brugia malayi AKH receptor 0.0022 0.0034 0.0063
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0034 0.0034
Brugia malayi protein kinase C3,putative 0.0019 0.0009 0.0009
Brugia malayi Protein kinase domain containing protein 0.0019 0.0009 0.0009
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0023 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0049 0.0222 0.0222
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0056 0.0274 0.0642
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0149 0.032
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0365
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0034 0.0034
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0084 0.149
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.257 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0026 0.0059 0.012
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0034 0.0063
Loa Loa (eye worm) TWK-7 protein 0.0023 0.0036 0.0068
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus granulosus peregrin 0.0096 0.0558 0.0558
Schistosoma mansoni BC026374 protein (S09 family) 0.0056 0.0274 0.0274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0206 0.0206
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0136 0.0197
Brugia malayi Protein kinase domain containing protein 0.0026 0.0059 0.012
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0023 0.0038 0.0038
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.015 1
Schistosoma mansoni protein kinase C mu 0.0019 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.015 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0019 0.0009 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.006 0.0493
Schistosoma mansoni biogenic amine (5HT) receptor 0.0141 0.0883 0.0883
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0336
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.015 0.0225
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0034 0.0034
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1608 0.3578
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.0181 0.0181
Entamoeba histolytica protein kinase, putative 0.0026 0.0059 0.3722
Onchocerca volvulus 0.0023 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0191 0.31
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0499 0.1245
Schistosoma mansoni inositol monophosphatase 0.0039 0.015 0.015
Echinococcus multilocularis acetylcholinesterase 0.0331 0.2238 0.2238
Brugia malayi hypothetical protein 0.0238 0.1576 0.3508
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0043 0.0181 0.0181
Echinococcus multilocularis serine:threonine protein kinase 38 0.0026 0.0059 0.0059
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0034 0.0055
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0023 0.0038 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0034 0.0034
Schistosoma mansoni alpha-glucosidase 0.0142 0.0888 0.0888
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0034 0.0034
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0195 0.0628
Echinococcus multilocularis Diacylglycerol kinase theta 0.0018 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.009 0.0515 0.9583
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0536 0.0536
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0023 0.0036 0.0068
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0331 0.2238 0.2238
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0499 0.1245
Brugia malayi neuropeptide F receptor 0.0022 0.0034 0.0063
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0149 0.2355
Brugia malayi hypothetical protein 0.002 0.0016 0.0024
Brugia malayi Cation transporter family protein 0.0043 0.0181 0.0392
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0026 0.0059 0.0059
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.015 0.0451
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0023 0.0036 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0136 0.0293
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0136 0.9042
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.0189 0.0411
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0029 0.0084 0.0084
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0047 0.0209 0.0209
Schistosoma mansoni acetylcholine receptor subunit beta 0.002 0.0016 0.0016
Trichomonas vaginalis spcc417.12 protein, putative 0.0056 0.0274 0.0469
Brugia malayi ORL1-like opioid receptor 0.0022 0.0034 0.0063
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0191 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0136 0.0396
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0026 0.0059 0.012
Echinococcus granulosus neuropeptide receptor 0.0022 0.0034 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0181 0.0392
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Onchocerca volvulus 0.0022 0.0034 0.0055
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.002 0.0016 0.0024
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0023 0.0036 0.0068
Echinococcus multilocularis raf serine:threonine protein kinase 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0169 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0189 0.0189
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0016 0.0016
Plasmodium vivax glutathione reductase, putative 0.0038 0.0149 0.2249
Schistosoma mansoni phosphatidylserine receptor 0.0045 0.0195 0.0195
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0016 0.0024
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0043 0.0181 0.0392
Brugia malayi hypothetical protein 0.002 0.0016 0.0024
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0036 0.0036
Onchocerca volvulus 0.0023 0.0036 0.006
Onchocerca volvulus 0.0043 0.0181 0.0343
Echinococcus granulosus somatostatin receptor 0.0022 0.0034 0.0034
Onchocerca volvulus 0.0056 0.0274 0.0526
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0034 0.0034
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0056 0.0274 0.0469
Brugia malayi GnHR receptor homolog 0.0022 0.0034 0.0063
Echinococcus multilocularis serine threonine protein kinase 0.0026 0.0059 0.0059
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0149 0.9905
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0333 0.2253 0.5019
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Echinococcus multilocularis BC026374 protein (S09 family) 0.0056 0.0274 0.0274
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0043 0.0181 0.0181
Loa Loa (eye worm) PHD-finger family protein 0.009 0.0515 0.1139
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.015 0.0285
Onchocerca volvulus 0.0023 0.0036 0.006
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0206
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0136 0.2468
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0043 0.0181 0.0392
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0149 0.0444
Echinococcus multilocularis protein kinase c eta type 0.0018 0.0005 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0034 0.0034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0499 0.1245
Schistosoma mansoni neuropeptide receptor 0.0022 0.0034 0.0034
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0034 0.0034
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0206 0.0447
Brugia malayi Bromodomain containing protein 0.0096 0.0558 0.1233
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0034 0.0063
Brugia malayi neuropeptide F receptor 0.0022 0.0034 0.0063
Onchocerca volvulus 0.002 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0333 0.2253 0.5019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0034 0.0034
Echinococcus granulosus fmrfamide receptor 0.0022 0.0034 0.0034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0023 0.0036 0.0068
Onchocerca volvulus 0.0056 0.0274 0.0526
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0136 0.0396
Brugia malayi Carboxylesterase family protein 0.0056 0.0274 0.0601
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0043 0.0181 0.0181
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0023 0.0036 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0169 0.2656
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0043 0.0181 0.0181
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.015 0.0451
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.015 0.0451
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.015 0.0451
Echinococcus multilocularis peregrin 0.0096 0.0558 0.0558
Echinococcus granulosus nAChR subunit 0.0023 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Toxoplasma gondii thioredoxin reductase 0.0038 0.0149 0.2696
Brugia malayi Melatonin receptor type 1A 0.0022 0.0034 0.0063
Onchocerca volvulus 0.0022 0.0034 0.0055
Schistosoma mansoni nAChR subunit 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0043 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) carboxylesterase 0.0056 0.0274 0.0601
Onchocerca volvulus 0.0022 0.0034 0.0055
Brugia malayi PHD-finger family protein 0.0031 0.0098 0.0208
Schistosoma mansoni opsin-like receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis 0.0041 0.0169 0.0169
Loa Loa (eye worm) ACC-1 protein 0.0043 0.0181 0.0392
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0034 0.0034
Brugia malayi follicle stimulating hormone receptor 0.0488 0.3358 0.7486
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0136 0.0197
Toxoplasma gondii ion channel protein 0.0023 0.0036 0.0577
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Trypanosoma brucei rac serine-threonine kinase, putative 0.0026 0.0059 0.0092
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Onchocerca volvulus 0.0043 0.0181 0.0343
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0169 0.0358
Schistosoma mansoni amine oxidase 0.0041 0.0169 0.0169
Brugia malayi Dopamine receptor 0.0022 0.0034 0.0063
Echinococcus multilocularis lysine specific demethylase 6a 0.0045 0.0195 0.0195
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0023 0.0036 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0034 0.0034
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0043 0.0181 0.0181
Brugia malayi hypothetical protein 0.0056 0.0274 0.0601
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0601
Onchocerca volvulus 0.0022 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0181 0.0392
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0034 0.0034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0023 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis carboxylesterase 5A 0.0331 0.2238 0.2238
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0043 0.0181 0.0181
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0019 0.0009 0.0009
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0023 0.0036 0.0036
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.257 0.5726
Echinococcus multilocularis Rac GTPase activating protein 1 0.0018 0.0005 0.0005
Echinococcus multilocularis somatostatin receptor 0.0022 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0191 0.3498
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0034 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0295 0.0645
Echinococcus granulosus lysine specific demethylase 6a 0.0045 0.0195 0.0195
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0084 0.0191
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0023 0.0036 0.0068
Echinococcus granulosus phd:f box containing protein 0.0045 0.0195 0.0195
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0016 0.0016
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0515 0.9607
Echinococcus multilocularis N chimaerin 0.0023 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0026 0.0059 0.012
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Echinococcus granulosus hypothetical protein 0.0022 0.0034 0.0034
Onchocerca volvulus 0.0022 0.0034 0.0055
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0354 0.2397 0.2397
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0191 0.3498
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0043 0.0181 0.0392
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0034 0.0063
Echinococcus multilocularis calcium activated potassium channel variant 0.0023 0.0036 0.0036
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0136 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0295 0.0696
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0034 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0034 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.017 0.1089 0.242
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) hypothetical protein 0.0141 0.0883 0.1959
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0034 0.0034
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0059 0.0059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0274 0.0274
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0034 0.0034
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0043 0.0181 0.0392
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Brugia malayi Protein kinase c protein 2 0.0019 0.0009 0.0009
Echinococcus multilocularis glycine receptor subunit beta 0.0043 0.0181 0.0181
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0043 0.0181 0.0392
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.004 0.0077
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1052 0.2338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0169 0.2656
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0195 0.0424
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0136 0.9042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0029 0.0054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.004 0.0077
Schistosoma mansoni neuroligin 3 (S09 family) 0.0056 0.0274 0.0274
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1576 0.1576
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0024
Brugia malayi hypothetical protein 0.0022 0.0034 0.0063
Schistosoma mansoni nAChR subunit 0.0043 0.0181 0.0181
Schistosoma mansoni gliotactin 0.0056 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0068
Loa Loa (eye worm) acetylcholine receptor protein 0.002 0.0016 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0295 0.0645
Schistosoma mansoni hypothetical protein 0.0329 0.2223 0.2223
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0392
Brugia malayi PHD-finger family protein 0.0029 0.0082 0.0172
Brugia malayi hypothetical protein 0.002 0.0016 0.0024
Loa Loa (eye worm) inositol-1 0.0039 0.015 0.0324
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0063
Brugia malayi AF-10 protein 0.0029 0.0084 0.0177

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12 nM Inhibition of human full length PKCtheta ChEMBL. 19111463
IC50 (binding) = 27 nM Inhibition of human full length PKCdelta ChEMBL. 19111463
IC50 (binding) = 1700 nM Inhibition of Lyn ChEMBL. 19111463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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