Detailed information for compound 993842

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.557 | Formula: C30H29NO
  • H donors: 1 H acceptors: 1 LogP: 6.87 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCc1ccccc1
  • InChi: 1S/C30H29NO/c32-29(31-24-22-25-13-5-1-6-14-25)21-23-30(26-15-7-2-8-16-26,27-17-9-3-10-18-27)28-19-11-4-12-20-28/h1-20H,21-24H2,(H,31,32)
  • InChiKey: WXHHCDPGIAJHIZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0099 0.018 0.5158
Echinococcus multilocularis expressed protein 0.0374 0.0763 0.0762
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0015 0.0014
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0032 0.0143
Entamoeba histolytica serine/threonine protein kinase, putative 0.0192 0.0377 0.2414
Entamoeba histolytica protein kinase rad3, putative 0.0246 0.049 0.3159
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0736 0.1528 0.4421
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.018 0.1933
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0038 0.0038
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0261 0.1648
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0018 0.0077
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0011 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.055 0.1134 0.74
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.01 0.0586
Brugia malayi hypothetical protein 0.0036 0.0046 0.0301
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0179 0.0349 0.2228
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0048 0.136
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0192 0.0377 0.188
Toxoplasma gondii FATC domain-containing protein 0.026 0.0521 0.5593
Echinococcus multilocularis expressed conserved protein 0.0082 0.0143 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0568 0.3673
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0179 0.035 0.1743
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.018 0.0897
Schistosoma mansoni hypothetical protein 0.0099 0.018 0.0795
Brugia malayi PXA domain containing protein 0.0021 0.0014 0.0087
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0011 0.0067
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0736 0.1528 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0033 0.0143
Brugia malayi Protein kinase domain containing protein 0.0018 0.0008 0.0048
Trypanosoma brucei Casein kinase II 0.0137 0.0261 0.2575
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0615 0.1271 0.8304
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0073 0.0322
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0159 0.0159
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0015 0.0028
Brugia malayi Csnk2b protein 0.0037 0.0048 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.0854 0.5557
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0169 0.0327 0.1445
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0048 0.0127
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0 0.0000000079185
Entamoeba histolytica hypothetical protein 0.0099 0.018 0.1116
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0409 0.2038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0051
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0027 0.0175
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.018 0.018
Toxoplasma gondii hypothetical protein 0.0054 0.0084 0.0897
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.029 0.1444
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.0652 0.0652
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0048 0.0047
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0058 0.0314
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0015 0.0028
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.0652 0.4266
Loa Loa (eye worm) hypothetical protein 0.0099 0.018 0.0897
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0048 0.0047
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0179 0.035 0.2285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Leishmania major cytochrome p450-like protein 0.0019 0.0011 0.0019
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0179 0.0349 0.0348
Loa Loa (eye worm) phosphatidylinositol 3 0.0428 0.0877 0.4374
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0349 0.0943
Echinococcus granulosus bloom syndrome protein 0.0021 0.0015 0.0014
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0051 0.0078 0.0215
Loa Loa (eye worm) phosphatidylinositol 3 0.0201 0.0396 0.1974
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0011 0.001
Onchocerca volvulus 0.0101 0.0183 0.2807
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0099 0.018 0.1116
Leishmania major hypothetical protein, conserved 0.1744 0.3661 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0179 0.0349 0.1541
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0011 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0033 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Onchocerca volvulus 0.0236 0.0469 0.7196
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0099 0.018 0.1116
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0048 0.0244
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0099 0.018 0.5029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.018 0.1176
Trypanosoma brucei polo-like protein kinase 0.0192 0.0377 0.3774
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0057 0.025
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Plasmodium vivax glycogen synthase kinase 3, putative 0.0051 0.0078 0.2234
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0174 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0219 0.1373
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.018 0.0897
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0011 0.001
Echinococcus multilocularis tumor protein p63 0.0339 0.0687 0.0687
Brugia malayi hypoxia-induced factor 1 0.0151 0.029 0.1894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.018 0.1116
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0478 0.0981 1
Mycobacterium ulcerans putative regulatory protein 0.002 0.0011 0.0007
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0051 0.0078 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Giardia lamblia Hypothetical protein 0.0099 0.018 0.1558
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0132
Leishmania major hypothetical protein, unknown function 0.0099 0.018 0.0481
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0048 0.0071 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0256 0.0513 0.331
Brugia malayi hypothetical protein 0.0019 0.0011 0.0067
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0051 0.0078 0.0839
Schistosoma mansoni single-minded 0.0049 0.0073 0.0322
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0 0.0000000079185
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0038 0.0166
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Echinococcus granulosus intermediate filament protein 0.0027 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.005 0.0075 0.0372
Trypanosoma cruzi target of rapamycin kinase 3 0.0459 0.0942 0.272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0246 0.049 0.3159
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1082 0.2261 0.226
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0179 0.0349 1
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0042
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0078 0.0445
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0005 0.0022
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0027 0.0027
Echinococcus multilocularis high voltage activated calcium channel beta 0.0087 0.0154 0.0154
Echinococcus granulosus expressed protein 0.0374 0.0763 0.0762
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0126 0.0126
Schistosoma mansoni kinase 0.0099 0.018 0.0793
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0078 0.0388
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0011 0.0051
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.007
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0048 0.1128
Echinococcus granulosus survival motor neuron protein 1 0.0473 0.097 0.097
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0478 0.0981 0.098
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0038 0.0038
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0201 0.0538
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0048 0.136
Brugia malayi FAT domain containing protein 0.0172 0.0334 0.2182
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0136 0.0258 0.2547
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.026 0.0521 0.2304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0617 0.3995
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0377 0.1082
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0346 0.0703 0.4597
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.03 0.0606 0.3924
Entamoeba histolytica hypothetical protein 0.0099 0.018 0.1116
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0032 0.0917
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.0652 0.2883
Loa Loa (eye worm) hypothetical protein 0.0473 0.097 0.4843
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0161 0.0311 0.0891
Brugia malayi PXA domain containing protein 0.0021 0.0014 0.0087
Brugia malayi Serotonin receptor 0.0468 0.096 0.6284
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0201 0.1956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0428 0.0877 0.5707
Mycobacterium ulcerans putative regulatory protein 0.002 0.0011 0.0007
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.01 0.0438
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0051
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0201 0.0886
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0027 0.0109
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0011 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0084 0.0481
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0341 0.0692 0.3452
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0137 0.0261 0.7475
Echinococcus granulosus single minded 2 0.0036 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0099 0.018 0.0511
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0121
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0033 0.0163
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0179 0.0349 0.2228
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Brugia malayi Pre-SET motif family protein 0.003 0.0033 0.0213
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0246 0.049 0.049
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0201 0.0396 0.1137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0046 0.0046
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0478 0.0981 0.4337
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0192 0.0377 0.102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0051
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0201 0.1
Schistosoma mansoni hypothetical protein 0.0169 0.0327 0.1445
Giardia lamblia GTOR 0.0478 0.0981 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0027 0.0109
Echinococcus multilocularis Zinc finger, PHD finger 0.0179 0.0349 0.0348
Entamoeba histolytica protein kinase, putative 0.0051 0.0078 0.0445
Schistosoma mansoni protein kinase 0.0137 0.0261 0.1152
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0078 0.0445
Plasmodium vivax SET domain protein, putative 0.003 0.0033 0.0933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0011 0.001
Brugia malayi phosphofructokinase 0.0109 0.0201 0.1312
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.018 0.1176
Loa Loa (eye worm) hypothetical protein 0.0172 0.0334 0.1664
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0201 0.0571
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0161 0.0311 0.1551
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0027
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0736 0.1528 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0027 0.0027
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0365 0.0743 0.4828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Mycobacterium leprae conserved hypothetical protein 0.0099 0.018 0.8908
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0099 0.018 0.1743
Onchocerca volvulus 0.0027 0.0027 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5814
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.03 0.0606 0.1746
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0143
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0179 0.0349 1
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Loa Loa (eye worm) phosphatidylinositol 3 0.0478 0.0981 0.4894
Echinococcus granulosus geminin 0.0169 0.0327 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0478 0.0981 0.6393
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0048 0.0725
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0418 0.0854 0.8692
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0246 0.049 0.049
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0011 0.0045
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0159 0.0703
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0099 0.018 0.0795
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0428 0.0877 0.2386
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0271 0.0544 0.5836
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.0211 0.0601
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0568 0.3673
Brugia malayi Casein kinase II, alpha chain 0.0137 0.0261 0.1704
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0038 0.0246
Toxoplasma gondii ck2 beta subunit 0.0037 0.0048 0.0512
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0099 0.018 0.0795
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0179 0.0349 0.0348
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0532 0.1097 0.1096
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0011 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0349 0.3482
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0099 0.018 0.0795
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0011 0.0045
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.018 0.1933
Echinococcus granulosus lamin dm0 0.0027 0.0027 0.0026
Toxoplasma gondii GAF domain-containing protein 0.002 0.0011 0.0121
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.1253
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0011 0.0045
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0048 0.0127
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.029 0.0583 0.5897
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0084 0.0481
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0051
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0174 0.1137
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0011 0.0045
Brugia malayi intracellular kinase 0.0051 0.0078 0.0509
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0346 0.0702 0.4559
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.0235
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0134
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0018 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Brugia malayi intermediate filament protein 0.0027 0.0027 0.0173
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0192 0.0377 0.0377
Brugia malayi serine/threonine-protein kinase plk-2 0.0192 0.0377 0.2465
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0478 0.0981 0.098
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0101 0.0183 0.0913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0459 0.0942 0.6135
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.0235
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0032 0.0674
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.1645 0.3451 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0075 0.033
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.1253
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0459 0.0942 0.2564
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0046 0.1861
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0011 0.0045
Loa Loa (eye worm) hypothetical protein 0.0101 0.0184 0.0915
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0468 0.0961 0.4248
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0201 0.02
Brugia malayi hypothetical protein 0.0101 0.0184 0.1199
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Brugia malayi hypothetical protein 0.0019 0.0011 0.0067
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0428 0.0877 0.8927
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0179 0.0349 0.0348
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.1253
Brugia malayi hypothetical protein 0.0473 0.097 0.635
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0018 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5814
Loa Loa (eye worm) hypothetical protein 0.0246 0.049 0.2445
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0192 0.0377 0.0377
Entamoeba histolytica hypothetical protein 0.026 0.0521 0.3364
Echinococcus granulosus expressed conserved protein 0.0082 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0127
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0172 0.0334 0.0333
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0201 0.1
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0137 0.0261 0.13
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0246 0.049 0.141
Leishmania major phosphatidylinositol 3-kinase, putative 0.0418 0.0854 0.2324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.0854 0.5557
Brugia malayi follicle stimulating hormone receptor 0.0237 0.0472 0.3086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0031 0.003
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.055 0.1134 0.74
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0179 0.0349 0.3743
Entamoeba histolytica hypothetical protein 0.0099 0.018 0.1116
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0018 0.0114
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0459 0.0942 0.6135
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0126 0.0126
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.028 0.1775
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0011 0.0045
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0048 0.0244
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0078 0.0484
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.026 0.0521 0.5261
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.026 0.0521 0.15
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.1253
Onchocerca volvulus 0.005 0.0075 0.1143
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.0472 0.2354
Trichomonas vaginalis conserved hypothetical protein 0.0271 0.0544 0.3514
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0459 0.0942 0.9599
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0032 0.0143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0051
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0468 0.0961 0.2775
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0033 0.0143
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0011 0.0052
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0478 0.0981 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0121
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0038 0.0038
Toxoplasma gondii target of rapamycin (TOR), putative 0.0454 0.0932 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0468 0.0961 0.6286
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0256 0.0513 0.331
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0046 0.0203
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0468 0.0961 0.096
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0478 0.0981 0.6393
Echinococcus multilocularis lamin 0.0027 0.0027 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0018 0.0077
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.018 0.1933
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0099 0.018 0.5029
Leishmania major phosphatidylinositol kinase related protein, putative 0.0114 0.0211 0.0566
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0038 0.0038
Plasmodium falciparum glycogen synthase kinase 3 0.0051 0.0078 0.2026
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.0235
Echinococcus granulosus high voltage activated calcium channel beta 0.0087 0.0154 0.0154
Echinococcus granulosus tumor protein p63 0.0339 0.0687 0.0687
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0032 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5813
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0048 0.0725
Brugia malayi 6-phosphofructokinase 0.0109 0.0201 0.1312
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0736 0.1528 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0033 0.0032
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Schistosoma mansoni hypothetical protein 0.0082 0.0143 0.0631
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0048 0.0244
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0143
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.01 0.0912
Plasmodium vivax hypothetical protein 0.0099 0.018 0.5158
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0179 0.0349 0.3743
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0201 0.02
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0201 0.0886
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0014 0.0066
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0032 0.0917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0478 0.0981 0.6393
Brugia malayi PAS domain containing protein 0.0049 0.0073 0.0477
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0011 0.001
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0011 0.0045
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0038 0.0166
Echinococcus multilocularis casein kinase ii subunit alpha 0.0137 0.0261 0.026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.018 0.1176
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0018 0.0077
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0099 0.018 0.1116
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0078 0.0445
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0172 0.0334 0.0333
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0011 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.01 0.0586
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0011 0.001
Leishmania major casein kinase II, putative 0.0137 0.0261 0.0702
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.018 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.1692 0.1691
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0159 0.0703
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.01 0.0277
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0078 0.0388
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0027 0.0132
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.018 0.018
Echinococcus granulosus protein kinase shaggy 0.0051 0.0078 0.0078
Brugia malayi Cytochrome P450 family protein 0.003 0.0033 0.0214
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Echinococcus multilocularis serine protein kinase ATM 0.026 0.0521 0.0521
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0468 0.0961 0.2775
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.1253
Schistosoma mansoni survival motor neuron protein 0.0096 0.0174 0.0768
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.01 0.0099
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0038 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0078 0.0445
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.007
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0249 0.0497 0.2482
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0736 0.1528 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0011 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0201 0.1253
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0033 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0441 0.0903 0.5879
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.0652 0.3253
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.03 0.0606 0.3924
Giardia lamblia Kinase, CMGC CK2 0.0137 0.0261 0.2409
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0046 0.0046
Onchocerca volvulus 0.0099 0.018 0.2756
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.018 0.018
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0099 0.018 0.1743
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.018 0.0897
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.018 0.8908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5813
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0377 0.1666
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0032 0.0347
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0099 0.018 0.0511
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.03 0.0606 0.3924
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0188
Schistosoma mansoni fkbp-rapamycin associated protein 0.0246 0.049 0.2166
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0078 0.0344
Echinococcus granulosus casein kinase ii subunit alpha 0.0137 0.0261 0.026
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0011 0.0053
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0469 0.3021
Entamoeba histolytica hypothetical protein 0.0615 0.1271 0.8304
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0162
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Brugia malayi Pre-SET motif family protein 0.0207 0.0409 0.2672
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0535 0.1102 0.721
Echinococcus multilocularis geminin 0.0169 0.0327 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5814
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0478 0.0981 0.2833
Brugia malayi Protein kinase domain containing protein 0.0322 0.0652 0.4266
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0478 0.0981 0.267
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.0652 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.0854 0.5557
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0099 0.018 0.5158
Echinococcus multilocularis cyclin dependent kinase 19 0.0134 0.0254 0.0254
Brugia malayi hypothetical protein 0.0164 0.0317 0.2069
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0736 0.1528 1
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0159 0.0159
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0048 0.012
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0349 0.1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0058 0.0157
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0201 0.1
Brugia malayi SH2 domain containing protein 0.0341 0.0692 0.4526
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0478 0.0981 0.6417
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0087 0.0154 0.068
Echinococcus multilocularis musashi 0.0027 0.0027 0.0026
Onchocerca volvulus 0.0027 0.0027 0.0404
Entamoeba histolytica casein kinase, putative 0.0137 0.0261 0.1648
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0478 0.0981 0.267
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0179 0.0349 0.1739
Echinococcus granulosus serine protein kinase ATM 0.026 0.0521 0.0521
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0032 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.03 0.0606 0.3964
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0027 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0454 0.0932 0.607
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0078 0.0078
Plasmodium falciparum casein kinase 2, alpha subunit 0.0137 0.0261 0.7407
Loa Loa (eye worm) hypothetical protein 0.0271 0.0544 0.2713
Toxoplasma gondii CMGC kinase, CK2 family 0.0137 0.0261 0.2799
Trypanosoma cruzi polo-like protein kinase, putative 0.0192 0.0377 0.1082
Schistosoma mansoni hypothetical protein 0.0036 0.0046 0.0203
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0134 0.0254 0.1266
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0201 1
Onchocerca volvulus 0.0101 0.0183 0.2807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0441 0.0903 0.5879
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0038 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0143
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0099 0.018 0.5158
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.01 0.0912
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.018 0.0897
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0179 0.0349 0.1541
Echinococcus multilocularis 0.0099 0.018 0.018
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5813
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1082 0.2261 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0011 0.0007
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0428 0.0876 0.8899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0459 0.0942 0.6135
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0038 0.0166
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0154 0.0153
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0179 0.0349 0.2228
Giardia lamblia Phosphatidylinositol 4-kinase 0.0099 0.018 0.1558
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0032 0.0143
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0018 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0478 0.0981 0.6393
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0032 0.0347
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0736 0.1528 0.4421
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0048 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.0632 0.4092
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0254 0.1122
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.03 0.0606 0.3924
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0154 0.0153
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0027 0.0173
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0018 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Leishmania major phosphatidylinositol 3-kinase, putative 0.0179 0.0349 0.0943
Giardia lamblia Casein kinase II beta chain 0.0037 0.0048 0.0163
Giardia lamblia Kinase, PLK 0.0192 0.0377 0.3635
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0348 0.0707 0.3127
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0011 0.001
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.01 0.0099
Schistosoma mansoni intermediate filament proteins 0.0027 0.0027 0.0116
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0033 0.0353
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0172 0.0334 0.1474
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0478 0.0981 0.2833
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.0652 0.3253
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0011 0.001
Onchocerca volvulus 0.0041 0.0057 0.0866
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.01 0.0586
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0468 0.0961 0.096
Plasmodium vivax unspecified product 0.0137 0.0261 0.7475
Leishmania major phosphatidylinositol kinase, putative 0.0099 0.018 0.0481
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0179 0.0349 0.2228
Echinococcus multilocularis survival motor neuron protein 1 0.0473 0.097 0.097
Plasmodium vivax hypothetical protein, conserved 0.002 0.0011 0.0312
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0099 0.018 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.0854 0.5557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0459 0.0942 0.6135
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.0053
Onchocerca volvulus 0.0036 0.0046 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414
Loa Loa (eye worm) RecQ helicase 0.0021 0.0015 0.0073
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.01 0.0586
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Schistosoma mansoni ankyrin 23/unc44 0.0014 0 0.000000035033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0893 0.5814
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0011 0.0067
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.018 0.1116
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0011 0.001
Trypanosoma cruzi casein kinase II, putative 0.0137 0.0261 0.0745
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0046 0.0301
Onchocerca volvulus 0.0099 0.018 0.2756
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0048 0.0378
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.0053
Onchocerca volvulus 0.0096 0.0174 0.2663
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0011 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0201 0.1253
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0011 0.0051
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Onchocerca volvulus Serine\/threonine kinase homolog 0.0192 0.0377 0.5778
Schistosoma mansoni lamin 0.0027 0.0027 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.028 0.1775
Loa Loa (eye worm) gastrulation defective protein 1 0.0131 0.0247 0.123
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0099 0.018 0.5158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0174 0.1079
Entamoeba histolytica hypothetical protein 0.0036 0.0046 0.0235
Brugia malayi Death domain containing protein 0.0014 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0334 0.2129
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0084 0.0481
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0221 0.0437 0.4271
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0078 0.0484
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0201 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0011 0.0067
Onchocerca volvulus 0.0051 0.0078 0.1193
Loa Loa (eye worm) calcium channel 0.0032 0.0038 0.0188
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0048 0.1128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.0521 0.3409
Loa Loa (eye worm) phosphatidylinositol 3 0.0961 0.2003 1
Loa Loa (eye worm) hypothetical protein 0.0532 0.1097 0.5474
Schistosoma mansoni hypothetical protein 0.0051 0.0079 0.0347
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0032 0.0674
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0246 0.049 0.3205
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0568 0.3673
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.01 0.0277
Brugia malayi Uncoordinated protein 44 0.0014 0 0.0001
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0038 0.0038
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0011 0.0067
Loa Loa (eye worm) phosphatidylinositol kinase 0.0099 0.018 0.0897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0459 0.0942 0.6135
Echinococcus multilocularis lamin dm0 0.0027 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.026 0.0521 0.3364
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0027 0.0109
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0179 0.0349 0.1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1082 0.2261 0.226
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0048 0.0236
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0015 0.0095
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0011 0.0045
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.03 0.0606 0.6136
Echinococcus granulosus lamin 0.0027 0.0027 0.0026
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0179 0.0349 0.2228
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0532 0.1097 0.1096
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0179 0.0349 0.228
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0201 1
Schistosoma mansoni hypothetical protein 0.0096 0.0174 0.0768
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0261 0.1648
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0099 0.018 0.0511
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0048 0.0512
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0032 0.0347
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0478 0.0981 0.6393
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0058 0.0314
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.01 0.0586
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0027 0.0132
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0637 0.1318 0.8615
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0011 0.0045
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0038 0.0038
Leishmania major phosphatidylinositol 4-kinase, putative 0.0099 0.018 0.0481
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.01 0.0277
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0578 0.3738
Echinococcus granulosus cyclin dependent kinase 19 0.0134 0.0254 0.0254
Schistosoma mansoni lamin 0.0027 0.0027 0.0116
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4739 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0099 0.018 0.0511
Loa Loa (eye worm) hypothetical protein 0.0164 0.0317 0.1578
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0048 0.0244
Brugia malayi 6-phosphofructokinase 0.0109 0.0201 0.1312
Brugia malayi Protein kinase domain containing protein 0.0134 0.0254 0.166
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0011 0.001
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0027 0.0175
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.0183 0.1198
Trypanosoma brucei protein kinase, putative 0.0051 0.0078 0.0692
Trichomonas vaginalis CAMK family protein kinase 0.0192 0.0377 0.2414

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.5 uM Growth inhibition of human SK-MEL-5 cells after 72 hrs by SRB assay ChEMBL. 18710803
IC50 (functional) = 50 uM Growth inhibition of human UACC62 cells after 72 hrs by SRB assay ChEMBL. 18710803

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18710803

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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