Detailed information for compound 1009898

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 510.024 | Formula: C28H32ClN3O4
  • H donors: 0 H acceptors: 3 LogP: 5.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCc1ccccc1C(=O)N(C(c1noc(n1)C)Cc1ccc(cc1)Cl)C1CCC2(CC1)OCCO2
  • InChi: 1S/C28H32ClN3O4/c1-3-21-6-4-5-7-24(21)27(33)32(23-12-14-28(15-13-23)34-16-17-35-28)25(26-30-19(2)36-31-26)18-20-8-10-22(29)11-9-20/h4-11,23,25H,3,12-18H2,1-2H3
  • InChiKey: RXLFSZALAMVPJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens complement component 5a receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis G-protein coupled receptor, putative complement component 5a receptor 1 350 aa 293 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi G-protein coupled receptor 0.0176 0.0892 0.0892
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0536 0.1153
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0128 0.0099
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0144 0.0194
Echinococcus granulosus peregrin 0.0028 0.0092 0.0116
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0035 0.0048
Schistosoma mansoni glutamate receptor kainate 0.0014 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0266 0.1383 0.1383
Loa Loa (eye worm) DR-78 0.0018 0.0035 0.0035
Echinococcus granulosus glycine receptor subunit beta 0.0034 0.0123 0.0153
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0828 0.4429 1
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0352 0.1931
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0125 0.0156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0129 0.0227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0013
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni nuclear receptor 0.0018 0.0035 0.0048
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0021 0.005 0.0062
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0047 0.0063
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0013 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0129 0.01
Echinococcus granulosus g protein coupled receptor 0.0176 0.0892 0.1115
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0076 0.0352 0.4705
Schistosoma mansoni biogenic amine receptor 0.0176 0.0892 0.12
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0029 0.0019
Echinococcus multilocularis GPCR, family 2 0.0063 0.0279 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0144 0.0144
Brugia malayi hypothetical protein 0.0148 0.0742 0.0742
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0141 0.0112
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0034 0.0123 0.0123
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Brugia malayi Pre-SET motif family protein 0.0223 0.1147 0.1147
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0062 0.0277 0.0563
Schistosoma mansoni ap endonuclease 0.0037 0.0141 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0352 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0129
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Brugia malayi CXXC zinc finger family protein 0.0028 0.0089 0.0089
Loa Loa (eye worm) beta-lactamase 0.0035 0.0129 0.0129
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.0063
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0176 0.0892 0.0892
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0034 0.0123 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0057 0.0071
Loa Loa (eye worm) hypothetical protein 0.0135 0.0671 0.0671
Schistosoma mansoni neuropeptide receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0603 0.1304
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0141 0.0255
Loa Loa (eye worm) hypothetical protein 0.1854 1 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.02 0.02
Echinococcus granulosus 7TM GPCR rhodopsin 0.0176 0.0892 0.1115
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0129 0.0227
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0279 0.0348
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0035 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0144 0.0194
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.1011
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0128 0.0099
Echinococcus granulosus glutamate receptor subunit protein glur 0.0014 0.0017 0.0021
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0035 0.0044
Loa Loa (eye worm) hypothetical protein 0.0287 0.1494 0.1494
Echinococcus granulosus biogenic amine 5HT receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0047 0.0059
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0144 0.0181
Echinococcus multilocularis neuropeptide s receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0692 0.0866
Giardia lamblia CDC72 0.0325 0.1701 1
Echinococcus granulosus nAChR subunit 0.0034 0.0123 0.0153
Brugia malayi putative neuropeptide receptor 0.0176 0.0892 0.0892
Echinococcus granulosus neuropeptide receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.123 0.6614 0.6614
Schistosoma mansoni hypothetical protein 0.0176 0.0892 0.12
Brugia malayi Cation transporter family protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) ACC-1 protein 0.0034 0.0123 0.0123
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0036
Leishmania major cytochrome p450-like protein 0.0019 0.0043 0.0014
Echinococcus granulosus neuropeptide s receptor 0.0176 0.0892 0.1115
Brugia malayi excitatory GABA receptor EXP-1A 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0287 0.1494 0.1494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0144 0.0181
Brugia malayi nuclear hormone receptor 0.0038 0.0144 0.0144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0603 0.1304
Echinococcus granulosus orexin receptor type 2 0.0176 0.0892 0.1115
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Schistosoma mansoni glutamate receptor AMPA 0.0014 0.0017 0.0023
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0176 0.0892 0.0892
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0047 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0144 0.0194
Brugia malayi Glutamate receptor 2 precursor 0.0014 0.0017 0.0017
Brugia malayi PHD-finger family protein 0.0028 0.0092 0.0092
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0176 0.0892 0.1115
Mycobacterium ulcerans monoamine oxidase 0.0076 0.0352 0.0671
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0386 0.2033 0.2033
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Leishmania major UDP-galactopyranose mutase 0.0076 0.0352 0.0324
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.0027
Loa Loa (eye worm) glutamate receptor 1 0.0014 0.0017 0.0017
Echinococcus granulosus neuropeptide receptor 0.0176 0.0892 0.1115
Onchocerca volvulus 0.0038 0.0144 0.0299
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0114 0.0143
Loa Loa (eye worm) hypothetical protein 0.0076 0.0352 0.0352
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0027 0.0033
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0325 0.1701 0.2126
Schistosoma mansoni zinc finger protein 0.0018 0.0035 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Echinococcus multilocularis 0.0076 0.0352 0.044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0042 0.0181
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.1011
Onchocerca volvulus 0.0032 0.0114 0.0231
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0034 0.0123 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0144 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0047 0.0063
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0035 0.0044
Brugia malayi nuclear receptor NHR-67 0.0018 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0114 0.0154
Echinococcus granulosus jumonji domain containing protein 0.004 0.0153 0.0191
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0035 0.0044
Entamoeba histolytica hypothetical protein 0.0037 0.0138 0.0748
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0057 0.0071
Echinococcus granulosus nAChR subunit 0.0013 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Brugia malayi ORL1-like opioid receptor 0.0176 0.0892 0.0892
Entamoeba histolytica hypothetical protein 0.0037 0.0138 0.0748
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0279 0.0279
Schistosoma mansoni glutamate receptor NMDA 0.0014 0.0017 0.0023
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0023 0.0063 0.104
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Echinococcus multilocularis geminin 0.0508 0.2692 0.3366
Echinococcus multilocularis serotonin transporter 0.0135 0.0671 0.0839
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0144 0.0144
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0144 0.0144
Schistosoma mansoni adenoreceptor 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.1381 0.7432 0.7432
Trypanosoma cruzi phytoene synthase, putative 0.0062 0.0277 0.0249
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0057 0.0071
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0836 0.4473 1
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0325 0.1701 0.2126
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0123 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0092 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0042 0.0029
Echinococcus granulosus serotonin receptor 0.0176 0.0892 0.1115
Schistosoma mansoni biogenic amine receptor 0.0176 0.0892 0.12
Echinococcus multilocularis sodium and chloride dependent glycine 0.0023 0.0063 0.0078
Brugia malayi neuropeptide F receptor 0.0176 0.0892 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0144 0.0144
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0023 0.0063 0.0084
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0037 0.014 0.0252
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Onchocerca volvulus 0.0176 0.0892 0.1974
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0034 0.0123 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0129 0.0635
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0014 0.0017 0.0021
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0037 0.014 0.023
Echinococcus granulosus sex peptide receptor 0.0176 0.0892 0.1115
Brugia malayi Cytochrome P450 family protein 0.0019 0.0043 0.0043
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0123 0.0165
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0123 0.0123
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0128 0.0099
Schistosoma mansoni neuropeptide F-like receptor 0.0176 0.0892 0.12
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0287 0.1494 0.201
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0042 0.0118
Echinococcus granulosus geminin 0.0508 0.2692 0.3366
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.005 0.005
Echinococcus granulosus biogenic amine 5HT receptor 0.1267 0.6813 0.8519
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi Dopamine receptor 0.0176 0.0892 0.0892
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0144 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Loa Loa (eye worm) ACC-1 protein 0.0034 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0062 0.0277 0.0373
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0043 0.0043
Onchocerca volvulus 0.0035 0.0129 0.0263
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0129
Schistosoma mansoni neuropeptide receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0123 0.0123
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0129 0.0161
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0176 0.0892 0.12
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0034 0.0123 0.0153
Echinococcus granulosus GPCR family 2 0.0063 0.0279 0.0348
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0144 0.0181
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0129 0.064 0.0861
Schistosoma mansoni biogenic amine (5HT) receptor 0.1267 0.6813 0.9168
Schistosoma mansoni hypothetical protein 0.0395 0.2082 0.2802
Brugia malayi nuclear receptor RXR 0.002 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0135 0.067 0.067
Trypanosoma brucei N-myristoyl transferase, putative 0.0325 0.1701 0.1693
Echinococcus granulosus glycine receptor subunit alpha 1 0.0034 0.0123 0.0153
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0035 0.0044
Schistosoma mansoni amine GPCR 0.0176 0.0892 0.12
Schistosoma mansoni smad1 5 8 and 0.0016 0.0027 0.0036
Brugia malayi TAR-binding protein 0.0066 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.1381 0.7432 0.7432
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.423 0.5288
Onchocerca volvulus 0.0023 0.0063 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0144 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0144 0.0194
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0032 0.0043
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0129 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0493
Schistosoma mansoni glutamate receptor AMPA 0.0014 0.0017 0.0023
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0023 0.0063 0.0084
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0035 0.0035
Schistosoma mansoni cpg binding protein 0.0028 0.0089 0.0119
Plasmodium falciparum protoporphyrinogen oxidase 0.0076 0.0352 0.1931
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0144 0.0194
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.02 0.025
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0128 0.0119
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0023 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0176 0.0892 0.1115
Brugia malayi nuclear hormone receptor 0.0018 0.0035 0.0035
Echinococcus granulosus tm gpcr rhodopsin 0.0176 0.0892 0.1115
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0138 0.0172
Echinococcus granulosus allatostatin A receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis g protein coupled receptor 0.0176 0.0892 0.1115
Echinococcus granulosus alpha 1A adrenergic receptor 0.0176 0.0892 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0493
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0034 0.0123 0.0123
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0035 0.0044
Loa Loa (eye worm) TYRA-2 protein 0.0176 0.0892 0.0892
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0021 0.005 0.005
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0057 0.0071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0138 0.0172
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0078 0.0361 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni hypothetical protein 0.0176 0.0892 0.12
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0123 0.0123
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0043 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Loa Loa (eye worm) acetylcholine receptor protein 0.0021 0.005 0.005
Brugia malayi Cytochrome P450 family protein 0.0019 0.0043 0.0043
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0129 0.0227
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0035 0.0044
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0144 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0129
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0129 0.0635
Onchocerca volvulus 0.0176 0.0892 0.1974
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0034 0.0123 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0399
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0042 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0027 0.0033
Brugia malayi AKH receptor 0.0176 0.0892 0.0892
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0129 0.0596
Echinococcus multilocularis neuropeptide receptor A26 0.0176 0.0892 0.1115
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.1239 0.1239
Brugia malayi glutathione reductase 0.0048 0.02 0.02
Brugia malayi follicle stimulating hormone receptor 0.0176 0.0892 0.0892
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Schistosoma mansoni histamine h1 receptor 0.0176 0.0892 0.12
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0133 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0352 0.1931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0325 0.1701 1
Echinococcus multilocularis g protein coupled receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0129 0.0173
Echinococcus granulosus neuropeptide FF receptor 2 0.0176 0.0892 0.1115
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0034 0.0123 0.0153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.005 0.005
Trypanosoma cruzi squalene synthase, putative 0.02 0.1025 0.0999
Plasmodium falciparum thioredoxin reductase 0.0048 0.02 0.1025
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni myosin xvIII 0.0176 0.0892 0.12
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0128 0.0632
Echinococcus granulosus cpg binding protein 0.0029 0.0097 0.0122
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0024 0.0068 0.0272
Echinococcus multilocularis Squalene phytoene synthase 0.0062 0.0277 0.0346
Echinococcus granulosus vesicular acetylcholine transporter 0.0836 0.4473 0.5593
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0034 0.0123 0.0153
Schistosoma mansoni N-myristoyltransferase 0.0325 0.1701 0.2288
Onchocerca volvulus 0.0034 0.0123 0.025
Onchocerca volvulus 0.0176 0.0892 0.1974
Schistosoma mansoni sodium-dependent amino acid transporter 0.0023 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi MH2 domain containing protein 0.024 0.1239 0.1239
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1854 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0279 0.0348
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0176 0.0892 0.0892
Brugia malayi hypothetical protein 0.0037 0.0138 0.0138
Loa Loa (eye worm) RNA binding protein 0.0066 0.0296 0.0296
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0076 0.0352 0.1931
Schistosoma mansoni sodium/chloride dependent transporter 0.0023 0.0063 0.0084
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0034 0.0123 0.0153
Toxoplasma gondii hypothetical protein 0.0031 0.0105 0.2285
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0057 0.0071
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Brugia malayi hypothetical protein 0.0021 0.005 0.005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.005 0.0062
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Loa Loa (eye worm) serotonin transporter b 0.0135 0.0671 0.0671
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0603 0.1304
Echinococcus multilocularis G protein coupled receptor 139 0.0176 0.0892 0.1115
Echinococcus multilocularis neuropeptides capa receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) G-protein coupled receptor 0.0176 0.0892 0.0892
Loa Loa (eye worm) N-myristoyltransferase 2 0.0325 0.1701 0.1701
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0021 0.005 0.005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0141 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0035 0.0044
Schistosoma mansoni alpha-1 adrenergic receptor 0.0176 0.0892 0.12
Entamoeba histolytica hypothetical protein 0.0037 0.0138 0.0748
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Brugia malayi hypothetical protein 0.0021 0.005 0.005
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0015 0.0022 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Onchocerca volvulus Neuropeptide F receptor homolog 0.0176 0.0892 0.1974
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0034 0.0123 0.0123
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0141 0.067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.1014 0.1014
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0176 0.0892 0.12
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0034 0.0123 0.0153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.005 0.005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0076 0.0352 0.1931
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0023 0.0063 0.0084
Schistosoma mansoni hypothetical protein 0.0063 0.0279 0.0375
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0034 0.0123 0.0153
Schistosoma mansoni neuropeptide receptor 0.0176 0.0892 0.12
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0023 0.0063 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium ulcerans phytoene synthase, CrtB 0.0062 0.0277 0.0515
Echinococcus granulosus sodium and chloride dependent glycine 0.0023 0.0063 0.0078
Schistosoma mansoni DNA polymerase eta 0.0019 0.0042 0.0056
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0034 0.0123 0.0123
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.0063
Echinococcus granulosus neuropeptide receptor A26 0.0176 0.0892 0.1115
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0123 0.0123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0005 0.0005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0034 0.0123 0.0153
Echinococcus granulosus serotonin transporter 0.0135 0.0671 0.0839
Onchocerca volvulus 0.0287 0.1494 0.3323
Brugia malayi larval opioid receptor 0.0176 0.0892 0.0892
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0023 0.0063 0.0084
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0014 0.0017 0.0021
Onchocerca volvulus 0.0176 0.0892 0.1974
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0076 0.0352 0.0473
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0176 0.0892 0.1115
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0176 0.0892 0.12
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0144 0.0181
Giardia lamblia PHD finger protein 15 0.0028 0.0092 0.038
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0043 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0692 0.0932
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Leishmania major DNA polymerase eta, putative 0.0019 0.0042 0.0013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0129 0.0129
Echinococcus multilocularis dna polymerase eta 0.0019 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0144 0.0181
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0443 0.0554
Onchocerca volvulus 0.0176 0.0892 0.1974
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0029 0.0019
Schistosoma mansoni hypothetical protein 0.0136 0.0674 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0399
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0129 0.0635
Echinococcus granulosus tm gpcr rhodopsin 0.1485 0.7998 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0021 0.005 0.0062
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0023 0.0063 0.0078
Onchocerca volvulus Alhambra homolog 0.0028 0.0092 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus somatostatin receptor 0.0176 0.0892 0.1115
Mycobacterium ulcerans dehydrogenase 0.0076 0.0352 0.0671
Echinococcus granulosus fmrfamide receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni neurotransmitter gated ion channel 0.0013 0.0011 0.0015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0296 0.0296
Onchocerca volvulus 0.0176 0.0892 0.1974
Schistosoma mansoni hypothetical protein 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0129 0.064 0.064
Mycobacterium tuberculosis Possible oxidoreductase 0.0076 0.0352 0.0734
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0034 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0032
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0176 0.0892 0.0892
Schistosoma mansoni sodium/chloride dependent transporter 0.0135 0.0671 0.0903
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0536 0.1153
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0176 0.0892 0.1115
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0027 0.0033
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0076 0.0352 0.1931
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0114 0.0154
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0144 0.0181
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0041 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0035 0.0048
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Brugia malayi nuclear receptor NHR-88 0.0038 0.0144 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0063 0.0201
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0076 0.0352 0.0671
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0141 0.0233
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0171 0.0231
Onchocerca volvulus 0.0023 0.0063 0.0115
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0144 0.0144
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0128 0.0119
Schistosoma mansoni hypothetical protein 0.0176 0.0892 0.12
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0092 0.0116
Schistosoma mansoni hypothetical protein 0.0063 0.0279 0.0375
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0123 0.0165
Plasmodium falciparum glutathione reductase 0.0048 0.02 0.1025
Echinococcus multilocularis G-protein coupled receptor, putative 0.0176 0.0892 0.1115
Echinococcus multilocularis neuropeptide Y receptor 0.0176 0.0892 0.1115
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Schistosoma mansoni cpg binding protein 0.0029 0.0097 0.0131
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0057 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0037 0.014 0.1725
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0129 0.0173
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0024 0.0068 0.0039
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0034 0.0123 0.0123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0114 0.2571
Loa Loa (eye worm) hypothetical protein 0.0062 0.0277 0.0277
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0035 0.0044
Mycobacterium ulcerans beta-lactamase 0.0035 0.0129 0.0207
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0043 0.0033
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0035 0.0035
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0176 0.0892 0.0892
Brugia malayi neuropeptide F receptor 0.0176 0.0892 0.0892
Onchocerca volvulus 0.0253 0.1313 0.2918
Schistosoma mansoni neuropeptide receptor 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0032 0.0114 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0141 0.0709
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0034 0.0123 0.0153
Onchocerca volvulus Putative nachr subunit 0.0034 0.0123 0.025
Loa Loa (eye worm) hypothetical protein 0.0948 0.5081 0.5081
Loa Loa (eye worm) hypothetical protein 0.0198 0.1014 0.1014
Schistosoma mansoni opsin-like receptor 0.0176 0.0892 0.12
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0047 0.0047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi jmjC domain containing protein 0.0093 0.0443 0.0443
Schistosoma mansoni coup transcription factor 0.0038 0.0144 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0141 0.0112
Plasmodium falciparum phd finger protein, putative 0.0028 0.0092 0.038
Loa Loa (eye worm) neuropeptide F receptor 0.0176 0.0892 0.0892
Plasmodium falciparum transporter, putative 0.0023 0.0063 0.0201
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus multilocularis sex peptide receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis g-protein coupled receptor 0.0176 0.0892 0.1115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0141 0.0112
Onchocerca volvulus 0.0021 0.005 0.0086
Mycobacterium tuberculosis Conserved protein 0.0035 0.0129 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0141 0.0768
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0141 0.067
Echinococcus multilocularis neuropeptide FF receptor 2 0.0176 0.0892 0.1115
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0176 0.0892 0.12
Onchocerca volvulus 0.0287 0.1494 0.3323
Onchocerca volvulus 0.0034 0.0123 0.025
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0144 0.0181
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0904 0.4842 1
Brugia malayi beta-lactamase family protein 0.0035 0.0129 0.0129
Echinococcus multilocularis neuropeptide receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis orexin receptor type 2 0.0176 0.0892 0.1115
Echinococcus granulosus tar DNA binding protein 0.0066 0.0296 0.037
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0023 0.0063 0.0078
Loa Loa (eye worm) hypothetical protein 0.0082 0.0382 0.0382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0144 0.0144
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0024 0.0068 0.0272
Brugia malayi G protein-coupled receptor F59B2.13 0.0176 0.0892 0.0892
Brugia malayi MH2 domain containing protein 0.0016 0.0027 0.0027
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0034 0.0123 0.0153
Brugia malayi MH1 domain containing protein 0.0016 0.0027 0.0027
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1381 0.7432 0.7432
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0144 0.0194
Trypanosoma cruzi N-myristoyl transferase, putative 0.0325 0.1701 0.1676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.1014 0.1014
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0692 0.0866
Trypanosoma brucei unspecified product 0.0019 0.0042 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0063 0.0279 0.0279
Echinococcus multilocularis serotonin receptor 0.1267 0.6813 0.8519
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Loa Loa (eye worm) Smad1 0.0016 0.0027 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0144 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0144 0.0181
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni hypothetical protein 0.0508 0.2692 0.3622
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0023 0.0063 0.0078
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0035 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Leishmania major hypothetical protein, conserved 0.0035 0.0129 0.01
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0138 0.0689
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0035 0.0044
Echinococcus granulosus glycine receptor subunit alpha 1 0.0034 0.0123 0.0153
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0092 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0257 0.0257
Echinococcus granulosus tm gpcr rhodopsin 0.0176 0.0892 0.1115
Echinococcus multilocularis NMDA receptor 0.0014 0.0017 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0399
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.005 0.005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.02 0.025
Schistosoma mansoni neuropeptide F-like receptor 0.0176 0.0892 0.12
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0019
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0176 0.0892 0.1115
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.0027
Onchocerca volvulus 0.0034 0.0123 0.025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0279 0.0279
Onchocerca volvulus 0.0135 0.0671 0.1479
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0043 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0124
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0129 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Brugia malayi N-myristoyltransferase 2 0.0325 0.1701 0.1701
Brugia malayi Serotonin receptor 0.0176 0.0892 0.0892
Loa Loa (eye worm) G-protein coupled receptor 0.0176 0.0892 0.0892
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0133 0.018
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0092 0.1911
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0176 0.0892 0.1974
Brugia malayi Dopamine receptor protein 2 0.0176 0.0892 0.0892
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.0218 0.0273
Echinococcus multilocularis Smad4 0.0016 0.0027 0.0033
Schistosoma mansoni amine GPCR 0.0176 0.0892 0.12
Schistosoma mansoni cpg binding protein 0.0029 0.0097 0.0131
Onchocerca volvulus 0.0018 0.0035 0.0054
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0042 0.0052
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0123 0.0165
Onchocerca volvulus 0.0287 0.1494 0.3323
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0135 0.0671 0.0903
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi putative neuropeptide receptor NPR1 0.0176 0.0892 0.0892
Echinococcus multilocularis fmrfamide receptor 0.0176 0.0892 0.1115
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.0218 0.0273
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0011 0.0015
Schistosoma mansoni growth hormone secretagogue receptor 0.0176 0.0892 0.12
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus granulosus peptide allatostatin:somatostatin 0.0176 0.0892 0.1115
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0129 0.0227
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1155 0.256
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) solute carrier family 6 member 4 0.0135 0.0671 0.0671
Entamoeba histolytica hypothetical protein 0.0037 0.0138 0.0748
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0047 0.0047
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0035 0.0044
Onchocerca volvulus 0.0028 0.0089 0.0173
Brugia malayi GnHR receptor homolog 0.0176 0.0892 0.0892
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0279 0.0348
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0035 0.0048
Echinococcus granulosus 7tm_1 domain containing protein 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Onchocerca volvulus 0.0176 0.0892 0.1974
Toxoplasma gondii ABC1 family protein 0.0035 0.0129 0.3003
Schistosoma mansoni acetylcholine receptor subunit beta 0.0021 0.005 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0279 0.0279
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0144 0.0144
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi nuclear receptor NHR-88 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0536 0.1153
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0144 0.0144
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0076 0.0352 0.0324
Schistosoma mansoni amine oxidase 0.0076 0.0352 0.0473
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.02 0.1025
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0105 0.0131
Giardia lamblia DINP protein human, muc B family 0.0019 0.0042 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis N-myristoyl transferase, putative 0.0213 0.1096 0.6399
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0144 0.0181
Brugia malayi RE15519p 0.0176 0.0892 0.0892
Schistosoma mansoni smad1 5 8 and 0.0016 0.0027 0.0036
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0176 0.0892 0.1115
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0138 0.0689
Brugia malayi G-protein coupled receptor 0.0176 0.0892 0.0892
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0057 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0144 0.0144
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0049 0.0203 0.0203
Echinococcus granulosus lysine specific histone demethylase 1A 0.0076 0.0352 0.044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Brugia malayi nuclear receptor RXR 0.0018 0.0035 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0692 0.0932
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis somatostatin receptor 0.0176 0.0892 0.1115
Brugia malayi Dopamine receptor protein 1 0.1154 0.6202 0.6202
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0144 0.0144
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0023 0.0063 0.0084
Brugia malayi beta-lactamase 0.0035 0.0129 0.0129
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0443 0.0554
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0536 0.1153
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0035 0.0048
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0013 0.0011 0.0015
Onchocerca volvulus 0.0023 0.0063 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Echinococcus multilocularis nAChR subunit 0.0013 0.0011 0.0014
Onchocerca volvulus 0.0135 0.067 0.1477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni ATP-binding cassette transporter 0.0014 0.0017 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0144 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0144 0.0194
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0141 0.0176
Loa Loa (eye worm) hypothetical protein 0.1267 0.6813 0.6813
Echinococcus granulosus neuropeptide Y receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.02 0.02
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0144 0.0144
Trypanosoma cruzi squalene synthase, putative 0.02 0.1025 0.0999
Schistosoma mansoni Smad4 0.0016 0.0027 0.0036
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0035 0.0054
Echinococcus granulosus g protein coupled receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis nAChR subunit 0.0034 0.0123 0.0153
Brugia malayi Serotonin receptor 0.062 0.3304 0.3304
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0029 0.0041
Echinococcus multilocularis glutamate receptor 2 0.0014 0.0017 0.0021
Echinococcus multilocularis glycine receptor subunit beta 0.0034 0.0123 0.0153
Schistosoma mansoni neuropeptide f receptor 76f 0.0176 0.0892 0.12
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0692 0.0866
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0176 0.0892 0.12
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0015 0.0022 0.0028
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0005 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0144 0.0194
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0129 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0114 0.0154
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis vesicular acetylcholine transporter 0.0836 0.4473 0.5593
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0034 0.0123 0.0153
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0042 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Schistosoma mansoni smad1 5 8 and 0.0016 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0092 0.1911
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0029 0.0041
Leishmania major trypanothione reductase 0.0048 0.02 0.0172
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0034 0.0123 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0144 0.0144
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0076 0.0352 0.1931
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0141 0.1744
Leishmania major DNA polymerase kappa, putative 0.0019 0.0042 0.0013
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0141 0.0141
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0152 0.019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0144 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0264 0.0355
Brugia malayi sulfakinin receptor protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Brugia malayi hypothetical protein 0.0076 0.0352 0.0352
Schistosoma mansoni nAChR subunit 0.0021 0.005 0.0067
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0296 0.0296
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.005 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Onchocerca volvulus 0.0176 0.0892 0.1974
Schistosoma mansoni amine GPCR 0.0176 0.0892 0.12
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0034 0.0123 0.0153
Leishmania major hypothetical protein, conserved 0.0062 0.0277 0.0249
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0035 0.0044
Chlamydia trachomatis protoporphyrinogen oxidase 0.0076 0.0352 1
Echinococcus multilocularis neuropeptide receptor 0.0176 0.0892 0.1115
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0034 0.0123 0.0123
Loa Loa (eye worm) LGC-31 protein 0.0034 0.0123 0.0123
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0176 0.0892 0.1115
Brugia malayi G protein-coupled receptor 0.0176 0.0892 0.0892
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1313 0.7694
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0399
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0043 0.0029
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0039
Brugia malayi conserved hypotetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0176 0.0892 0.12
Toxoplasma gondii histone lysine-specific demethylase 0.0076 0.0352 0.9724
Brugia malayi Smad1 0.0016 0.0027 0.0027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0129 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0144 0.0181
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0171 0.0231
Echinococcus multilocularis sodium and chloride dependent glycine 0.0023 0.0063 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.1011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1381 0.7432 1
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.1147 0.1147
Echinococcus multilocularis dro:myosuppressin receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Brugia malayi hypothetical protein 0.002 0.0047 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0144 0.0181
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Schistosoma mansoni hypothetical protein 0.0508 0.2692 0.3622
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) neuropeptide F receptor 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0037 0.0138 0.0185
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0296 0.0296
Brugia malayi RNA binding protein 0.0066 0.0296 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0144 0.0144
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0176 0.0892 0.1115
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0152 0.0152
Echinococcus granulosus G protein coupled receptor 139 0.0176 0.0892 0.1115
Treponema pallidum sodium- and chloride- dependent transporter 0.0135 0.0671 1
Echinococcus multilocularis allatostatin A receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0129 0.064 0.08
Loa Loa (eye worm) glutamate receptor 2 0.0014 0.0017 0.0017
Brugia malayi hypothetical protein 0.002 0.0047 0.0047
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1485 0.7998 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Echinococcus granulosus glycine receptor subunit alpha 1 0.0034 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Schistosoma mansoni glutamate receptor kainate 0.0014 0.0017 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.023 0.6047
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0129 0.0635
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0904 0.4842 1
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0023 0.0063 0.0063
Loa Loa (eye worm) GABA receptor subunit 0.0013 0.0011 0.0011
Leishmania major squalene synthase, putative 0.02 0.1025 0.0999
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0176 0.0892 0.12
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0176 0.0892 0.1115
Brugia malayi Cation transporter family protein 0.0034 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0493
Echinococcus granulosus Squalene phytoene synthase 0.0062 0.0277 0.0346
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0129 0.0227
Brugia malayi hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni acetylcholine receptor-related 0.0021 0.005 0.0067
Echinococcus granulosus lysine specific histone demethylase 1A 0.0129 0.064 0.08
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0536 0.8593
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0021 0.005 0.005
Brugia malayi MH1 domain containing protein 0.0016 0.0027 0.0027
Echinococcus granulosus dna polymerase kappa 0.0019 0.0042 0.0052
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0034 0.0123 0.0153
Onchocerca volvulus 0.0018 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0176 0.0892 0.1115
Trypanosoma cruzi UDP-galactopyranose mutase 0.0076 0.0352 0.0324
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0144 0.0299
Echinococcus multilocularis g protein coupled receptor 0.0176 0.0892 0.1115
Trypanosoma brucei C-8 sterol isomerase, putative 0.1854 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.1014 0.1014
Brugia malayi Glutamate receptor 1 precursor 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0062 0.0277 0.0595
Echinococcus multilocularis fmrfamide receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni nAChR subunit 0.0021 0.005 0.0067
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Toxoplasma gondii thioredoxin reductase 0.0048 0.02 0.5161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0128 0.016
Brugia malayi SWIRM domain containing protein 0.0135 0.067 0.067
Schistosoma mansoni amine GPCR 0.0176 0.0892 0.12
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0021 0.005 0.0062
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.0218 0.0273
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0035 0.0035
Brugia malayi hypothetical protein 0.0023 0.0063 0.0063
Toxoplasma gondii hypothetical protein 0.0023 0.0063 0.1011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0035 0.0054
Brugia malayi Bromodomain containing protein 0.0028 0.0092 0.0092
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0015 0.0022 0.0028
Brugia malayi jmjC domain containing protein 0.0036 0.0133 0.0133
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0042 0.0013
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0133 0.0167
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0144 0.0181
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus granulosus glutamate receptor 2 0.0022 0.0057 0.0071
Brugia malayi hypothetical protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0014 0.0017 0.0021
Schistosoma mansoni hypothetical protein 0.0028 0.0092 0.0124
Loa Loa (eye worm) hypothetical protein 0.1154 0.6202 0.6202
Echinococcus multilocularis smad 0.0016 0.0027 0.0033
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0023 0.0063 0.0078
Echinococcus granulosus dna polymerase eta 0.0019 0.0042 0.0052
Echinococcus granulosus g-protein coupled receptor 0.0176 0.0892 0.1115
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0029 0.0036
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0035 0.0035
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0144 0.0144
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus granulosus Smad4 0.0016 0.0027 0.0033
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0176 0.0892 0.1115
Mycobacterium tuberculosis Conserved protein 0.0035 0.0129 0.0227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0013
Loa Loa (eye worm) hypothetical protein 0.0135 0.0671 0.0671
Leishmania major N-myristoyl transferase, putative 0.0325 0.1701 0.1676
Brugia malayi vesicular acetylcholine transporter unc-17 0.0836 0.4473 0.4473
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis cpg binding protein 0.0029 0.0097 0.0122
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0057 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0129 0.0227
Echinococcus multilocularis neuropeptides capa receptor 0.0176 0.0892 0.1115
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0144 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0692 0.0692
Mycobacterium ulcerans hypothetical protein 0.0035 0.0129 0.0207
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0176 0.0892 0.12
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.005 0.0062
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0014 0.0017 0.0021
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0032
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0176 0.0892 0.12
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Schistosoma mansoni biogenic amine receptor 0.0176 0.0892 0.12
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0399
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0063 0.0279 0.0375
Loa Loa (eye worm) hypothetical protein 0.0136 0.0674 0.0674
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0114 0.0154
Echinococcus granulosus neuropeptides capa receptor 0.0176 0.0892 0.1115
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.02 0.0172
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0176 0.0892 0.1115
Schistosoma mansoni ap endonuclease 0.0037 0.0141 0.019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0674 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0144 0.0144
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.02 0.0389
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0013
Echinococcus multilocularis neuropeptide Y receptor 0.0176 0.0892 0.1115
Echinococcus granulosus tachykinin peptides receptor 99D 0.0176 0.0892 0.1115
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0057 0.0077
Mycobacterium ulcerans oxidoreductase 0.0076 0.0352 0.0671
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Schistosoma mansoni amine oxidase 0.0076 0.0352 0.0473
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0325 0.1701 1
Schistosoma mansoni nuclear receptor 0.0018 0.0035 0.0048
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0141 0.067
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0023 0.0063 0.0084
Trypanosoma brucei N-myristoyltransferase 0.0325 0.1701 0.1693
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0015 0.0022 0.0022
Schistosoma mansoni vesicular acetylcholine transporter 0.0836 0.4473 0.6019
Echinococcus granulosus rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis serotonin receptor 0.1267 0.6813 0.8519
Echinococcus granulosus neuropeptide Y receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0092
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0035 0.0035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0034 0.0123 0.0123
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0021 0.005 0.005
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0128 0.0632
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Schistosoma mansoni jumonji domain containing protein 0.0074 0.034 0.0457
Brugia malayi hypothetical protein 0.0176 0.0892 0.0892
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0296 0.037
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0135 0.0671 0.0671
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0034 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0129
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0034 0.0123 0.0123
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0035 0.0048
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0138 0.0185
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0042 0.0118
Schistosoma mansoni amine GPCR 0.0176 0.0892 0.12
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.1239 0.1239
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2082 0.2603
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0144 0.0194
Schistosoma mansoni glutamate receptor kainate 0.0014 0.0017 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0176 0.0892 0.1115
Loa Loa (eye worm) norepinephrine transporter 0.0135 0.0671 0.0671
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0014 0.0017 0.0021
Mycobacterium tuberculosis Probable reductase 0.011 0.0536 0.1153
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0144 0.0194
Trypanosoma brucei trypanothione reductase 0.0048 0.02 0.0191
Onchocerca volvulus 0.0021 0.005 0.0086
Trypanosoma brucei squalene synthase, putative 0.02 0.1025 0.1016
Plasmodium vivax glutathione reductase, putative 0.0048 0.02 0.1025
Brugia malayi tailless protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni hypothetical protein 0.0063 0.0279 0.0375
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0128 0.016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0144 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0144 0.0144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0114 0.0143
Loa Loa (eye worm) hypothetical protein 0.0076 0.0352 0.0352
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0035 0.0035
Toxoplasma gondii hypothetical protein 0.0023 0.0063 0.1011
Brugia malayi hypothetical protein 0.0021 0.005 0.005
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0034 0.0123 0.0123
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0027 0.0036
Chlamydia trachomatis glutamine binding protein 0.0037 0.014 0.3432
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0123
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0023 0.0063 0.0084
Trichomonas vaginalis N-myristoyl transferase, putative 0.0325 0.1701 1
Schistosoma mansoni opsin-like receptor 0.0176 0.0892 0.12
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0034 0.0123 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0692 0.0692
Echinococcus granulosus hypothetical protein 0.0176 0.0892 0.1115
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0133 0.0133
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0023 0.0063 0.0078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0129 0.0207
Echinococcus granulosus g protein coupled receptor 0.0176 0.0892 0.1115
Brugia malayi Melatonin receptor type 1A 0.0176 0.0892 0.0892
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0144 0.0144
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0114 0.0143
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0279 0.0348
Echinococcus multilocularis protoporphyrinogen oxidase 0.0076 0.0352 0.044
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.005 0.0067
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0011 0.0011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0144 0.0181
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0325 0.1701 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Trichomonas vaginalis esterase, putative 0.0035 0.0129 0.0635
Brugia malayi Thioredoxin reductase 0.0048 0.02 0.02
Trypanosoma cruzi N-myristoyl transferase, putative 0.0325 0.1701 0.1676
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Echinococcus granulosus glycine receptor subunit beta 0.0034 0.0123 0.0153
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0034 0.0123 0.0153
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0141 0.0709
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Onchocerca volvulus 0.0176 0.0892 0.1974
Leishmania major C-8 sterol isomerase-like protein 0.1854 1 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0034 0.0123 0.0123
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0023 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.1267 0.6813 0.6813
Echinococcus granulosus dro:myosuppressin receptor 0.0176 0.0892 0.1115
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0144 0.0194
Plasmodium vivax amine transporter, putative 0.0023 0.0063 0.0201
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0141 0.0176
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0176 0.0892 0.12
Brugia malayi steroid hormone receptor 0.0038 0.0144 0.0144
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0152 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0176 0.0892 0.0892
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0144 0.0181
Brugia malayi MH2 domain containing protein 0.0016 0.0027 0.0027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0089 0.0089
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0011 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0692 0.0866
Echinococcus granulosus smad 0.0016 0.0027 0.0033
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0536 0.1153
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0287 0.1494 0.201
Onchocerca volvulus 0.0035 0.0129 0.0263
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0176 0.0892 0.1115
Mycobacterium tuberculosis Conserved protein 0.0035 0.0129 0.0227
Onchocerca volvulus 0.0021 0.005 0.0086
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0176 0.0892 0.1115
Brugia malayi Cation transporter family protein 0.0287 0.1494 0.1494
Brugia malayi hypothetical protein 0.0021 0.005 0.005
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0027 0.0033
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0027 0.0027
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Onchocerca volvulus 0.0035 0.0129 0.0263
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Brugia malayi ecdysone receptor 0.0018 0.0035 0.0035
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0836 0.4473 0.4473
Toxoplasma gondii exonuclease III APE 0.0037 0.0141 0.3374
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0023 0.0063 0.0078
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0176 0.0892 0.1115
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2082 0.2603
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0023
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0037 0.014 0.1725
Onchocerca volvulus 0.0176 0.0892 0.1974
Brugia malayi ecdysteroid receptor 0.0038 0.0144 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0129 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0176 0.0892 0.1115
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0042 0.0029
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0037 0.014 0.3432
Loa Loa (eye worm) hypothetical protein 0.0135 0.0671 0.0671
Schistosoma mansoni sodium/chloride dependent transporter 0.0023 0.0063 0.0084
Schistosoma mansoni nAChR subunit 0.0034 0.0123 0.0165
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Echinococcus granulosus sodium and chloride dependent glycine 0.0023 0.0063 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0043 0.0043
Onchocerca volvulus 0.0176 0.0892 0.1974
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0063
Schistosoma mansoni opsin-like receptor 0.0176 0.0892 0.12
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0603 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0057 0.0071
Echinococcus granulosus glutamate NMDA receptor subunit 0.0014 0.0017 0.0021
Loa Loa (eye worm) melatonin receptor type 1A 0.0176 0.0892 0.0892
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0153 0.0191
Plasmodium falciparum amino acid transporter, putative 0.0023 0.0063 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0692 0.0932
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0035 0.0128 0.0172
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0144 0.0299
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0129
Echinococcus multilocularis glycine receptor subunit beta 0.0034 0.0123 0.0153
Echinococcus multilocularis peregrin 0.0028 0.0092 0.0116
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0176 0.0892 0.0892
Schistosoma mansoni smad 0.0016 0.0027 0.0036
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0034 0.0123 0.0153
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0128 0.0632
Brugia malayi amine oxidase, flavin-containing family protein 0.0082 0.0382 0.0382
Mycobacterium ulcerans lipase LipD 0.0035 0.0129 0.0207
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0176 0.0892 0.0892
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0129
Plasmodium vivax SET domain protein, putative 0.0032 0.0114 0.0511
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0092 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0129 0.0635
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0141 0.0131
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0176 0.0892 0.0892
Brugia malayi beta-lactamase family protein 0.0035 0.0129 0.0129
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0129 0.0119
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0034 0.0123 0.0123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0176 0.0892 0.1115
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0176 0.0892 0.1115
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0176 0.0892 0.0892
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0129 0.0227

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8 nM Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assay ChEMBL. 18804369
IC50 (functional) = 40 nM Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 mins prior to C5a challenge using p-nitroanilide as substrate ChEMBL. 18804369

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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