TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 261.272 | Formula: C13H8FNO2S
H donors: 1 H acceptors: 2 LogP: 2.76 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc(c1)n1sc2c(c1=O)cccc2F
InChi: 1S/C13H8FNO2S/c14-11-6-2-5-10-12(11)18-15(13(10)17)8-3-1-4-9(16)7-8/h1-7,16H
InChiKey: CULCLVLIEPNXCD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Macrophage migration inhibitory factor, related	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania major	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium falciparum	macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Loa Loa (eye worm)	macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium berghei	macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium knowlesi	macrophage migration inhibitory factor, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_129767	All targets in OG5_129767
Brugia malayi	Bm-MIF-1, identical	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania donovani	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania major	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania mexicana	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_129767	All targets in OG5_129767
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Toxoplasma gondii	macrophage migration inhibitory factor, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Giardia lamblia	Macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania infantum	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium vivax	macrophage migration inhibitory factor, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania infantum	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania mexicana	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania donovani	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania braziliensis	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0021	0.0178	0.0119
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0825	0.1272
Schistosoma mansoni	cpg binding protein	0.0059	0.0665	0.0665
Leishmania major	cytochrome p450-like protein	0.0021	0.0178	0.0278
Loa Loa (eye worm)	acetyltransferase	0.014	0.1692	0.5493
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0021	0.0178	0.0119
Onchocerca volvulus	Glucosylceramidase homolog	0.0164	0.1993	1
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0024	0.0224	0.0892
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0477	0.0477
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.0757	0.2456
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0017	0.0017
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0305	0.0305
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0825	0.2672
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0825	0.1272
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Schistosoma mansoni	ap endonuclease	0.0018	0.0147	0.0147
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0021	0.0178	0.0464
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0112	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0757	0.2456
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0147	0.0476
Trypanosoma brucei	cytochrome P450, putative	0.0046	0.0503	0.5481
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0021	0.0178	0.0464
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.3081	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.2105	0.6828
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0017	0.0017
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0021	0.0178	0.0119
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0147	0.0476
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0825	0.2672
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.1692	0.5493
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0825	0.2677
Leishmania major	hypothetical protein, conserved	0.0072	0.0825	0.2971
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0021	0.0178	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1146	0.3718
Brugia malayi	beta-lactamase family protein	0.0072	0.0825	0.2677
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0147	0.0147
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0458	0.5722	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0017	0.0017
Brugia malayi	beta-lactamase family protein	0.0072	0.0825	0.2677
Toxoplasma gondii	t-complex protein beta subunit	0.0024	0.0224	0.0469
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0077	0.0241
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0825	0.0825
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0112	0.0111
Brugia malayi	T-complex protein 1, beta subunit	0.0024	0.0224	0.0727
Trypanosoma cruzi	cytochrome P450, putative	0.0046	0.0503	0.5481
Leishmania major	cytochrome p450-like protein	0.0021	0.0178	0.0278
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0092	0.0092
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0147	0.0147
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0147	0.0469
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0825	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0147	0.0469
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0825	0.0825
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.1301	0.4953
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0021	0.0178	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0825	0.2677
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0077	0.0241
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0477	0.0477
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0021	0.0178	0.0119
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0018	0.0018
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0825	0.2971
Schistosoma mansoni	cpg binding protein	0.0056	0.0624	0.0624
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0021	0.0178	0.0119
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0825	1
Mycobacterium ulcerans	lipase LipD	0.0072	0.0825	1
Trichomonas vaginalis	esterase, putative	0.0072	0.0825	0.2672
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0147	0.0147
Brugia malayi	Bm-MIF-1, identical	0.0205	0.2513	0.8158
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Onchocerca volvulus		0.0072	0.0825	0.1466
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0017	0.0017
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0825	1
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0021	0.0178	0.0464
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0305	0.099
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0825	0.1272
Giardia lamblia	Macrophage migration inhibitory factor	0.0205	0.2513	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0305	0.0305
Schistosoma mansoni	hypothetical protein	0.0031	0.0305	0.0305
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0021	0.0178	0.0119
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0021	0.0178	0.0119
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0205	0.2513	0.8158
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0439	0.1362
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0087	0.1024	0.3324
Echinococcus multilocularis	neuropeptide s receptor	0.045	0.5621	0.562
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0439	0.1417
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0024	0.0224	0.1579
Echinococcus multilocularis	cpg binding protein	0.0059	0.0665	0.0665
Schistosoma mansoni	hypothetical protein	0.0031	0.0305	0.0305
Echinococcus multilocularis		0.0021	0.0178	0.0178
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0825	1
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0021	0.0178	0.0464
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0017	0.0054
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0825	1
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0021	0.0178	0.0464
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0077	0.0241
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0825	0.2672
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0024	0.0224	0.1579
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0077	0.0241
Echinococcus granulosus	neuropeptide receptor A26	0.045	0.5621	0.562
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0825	0.2677
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0021	0.0178	0.0278
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0021	0.0178	0.0464
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0021	0.0178	0.0278
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0017	0.0054
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0178	0.0578
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0305	0.099
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0477	0.0477
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.3081	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0147	0.5
Schistosoma mansoni	smad	0.0008	0.0017	0.0017
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0825	0.2677
Brugia malayi	beta-lactamase	0.0072	0.0825	0.2677
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0024	0.0224	0.0892
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0147	0.0496
Brugia malayi	MH1 domain containing protein	0.0008	0.0017	0.0054
Echinococcus granulosus	smad	0.0008	0.0017	0.0017
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0112	0.0361
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0305	0.099
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0825	0.2677
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1394	0.4524
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0224	0.0224
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0092	0.0092
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0305	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Echinococcus multilocularis	dnaJ subfamily B	0.0795	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0477	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0825	0.2677
Onchocerca volvulus		0.0072	0.0825	0.1466
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0024	0.0224	0.0224
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0205	0.2513	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0021	0.0178	0.0119
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0147	0.0147
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0118	0.1418	0.1418
Loa Loa (eye worm)	T-complex protein 1	0.0024	0.0224	0.0727
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Brugia malayi	MH2 domain containing protein	0.0116	0.1394	0.4524
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0477	0.0477
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0825	0.1272
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0017	0.0017
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0477	0.1547
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.3081	1
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0024	0.0224	0.0224
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0021	0.0178	0.0464
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.2105	0.6828
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0825	0.2672
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0112	0.0111
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0112	0.0361
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0021	0.0178	0.0464
Leishmania major	macrophage migration inhibitory factor-like protein	0.0205	0.2513	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0021	0.0178	0.0119
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0017	0.0017
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.3081	1
Schistosoma mansoni	hypothetical protein	0.0021	0.0178	0.0178
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0249	0.3081	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0046	0.0503	0.1631
Trypanosoma cruzi	cytochrome P450, putative	0.0046	0.0503	0.5481
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0305	0.099
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0112	0.0111
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0024	0.0224	0.072
Echinococcus multilocularis	Smad4	0.0008	0.0017	0.0017
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0021	0.0178	0.0464
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0021	0.0178	0.0937
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0205	0.2513	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0112	0.0111
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0395	0.1572
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0021	0.0178	0.0464
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0205	0.2513	1
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0825	0.1272
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0021	0.0178	0.0464
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0825	0.1272
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0021	0.0178	0.0119
Echinococcus granulosus	cpg binding protein	0.0059	0.0665	0.0665
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0439	0.0438
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0021	0.0178	0.0464
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0112	0.0111
Plasmodium falciparum	macrophage migration inhibitory factor	0.0205	0.2513	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0305	0.0305
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0825	1
Trichomonas vaginalis	helicase, putative	0.0013	0.0077	0.0241
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.1146	0.3718
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.1146	0.3718
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0147	0.0063
Brugia malayi	Cytochrome P450 family protein	0.0046	0.0503	0.1631
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0395	0.1572
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0112	0.0112
Schistosoma mansoni	hypothetical protein	0.0795	1	1
Schistosoma mansoni	cytochrome P450	0.0021	0.0178	0.0178
Brugia malayi	MH2 domain containing protein	0.0008	0.0017	0.0054
Toxoplasma gondii	exonuclease III APE	0.0018	0.0147	0.0147
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0092	0.0092
Brugia malayi	MH1 domain containing protein	0.0008	0.0017	0.0054
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0624	0.2026
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.3081	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0477	0.0477
Loa Loa (eye worm)	CYP4Cod1	0.0046	0.0503	0.1631
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.1146	0.3718
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0021	0.0178	0.0937
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0092	0.0092
Echinococcus multilocularis	neuropeptide receptor A26	0.045	0.5621	0.562
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0147	0.0584
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0087	0.1024	0.3324
Leishmania major	cytochrome p450-like protein	0.0046	0.0503	0.1628
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.0136	0.0135
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0783	0.9852	0.9852
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0021	0.0178	0.0464
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0305	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0825	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Brugia malayi	MH2 domain containing protein	0.0008	0.0017	0.0054
Schistosoma mansoni	hypothetical protein	0.0031	0.0305	0.0305
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0021	0.0178	0.0937
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0147	0.0496
Leishmania major	T-complex protein 1, beta subunit, putative	0.0024	0.0224	0.0469
Echinococcus granulosus	neuropeptide s receptor	0.045	0.5621	0.562
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0477	0.0477
Trichomonas vaginalis	chaperonin, putative	0.0024	0.0224	0.072
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0439	0.1362
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0825	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0305	0.0305
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0024	0.0224	0.0469
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.1692	0.1692
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0477	0.1547
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0021	0.0178	0.0464
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0077	0.0241
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0825	1
Brugia malayi	Cytochrome P450 family protein	0.0076	0.0885	0.287
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0092	0.0092
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0077	0.0241
Brugia malayi	Cytochrome P450 family protein	0.0046	0.0503	0.1631
Loa Loa (eye worm)	histone methyltransferase	0.0017	0.0136	0.0439
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0147	0.5
Leishmania major	macrophage migration inhibitory factor-like protein	0.0205	0.2513	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0439	0.1417
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1394	0.4524
Brugia malayi	Smad1	0.0008	0.0017	0.0054
Loa Loa (eye worm)	cytochrome P450 family protein	0.0076	0.0885	0.287
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0825	0.2677
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.1692	0.1692
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0205	0.2513	0.8157
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0017	0.0017
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0021	0.0178	0.0119
Brugia malayi	cytochrome P450	0.0021	0.0178	0.0578
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0021	0.0178	0.0119
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.1643	0.1642
Loa Loa (eye worm)	Smad1	0.0008	0.0017	0.0054
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0024	0.0224	0.0326
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0147	0.0496
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0046	0.0503	0.5245
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0021	0.0178	0.0119
Loa Loa (eye worm)	cytochrome P450 family protein	0.0046	0.0503	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0825	0.2677
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0439	0.1362
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0825	0.1272
Echinococcus multilocularis	geminin	0.0165	0.2005	0.2005
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0825	0.0825
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0224	0.0224
Schistosoma mansoni	ap endonuclease	0.0018	0.0147	0.0147
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0021	0.0178	0.0119
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0077	0.0241
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0077	0.0241
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0825	0.1272
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0825	0.0825
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0624	0.2026
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0021	0.0178	0.0119
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0133	0.043
Echinococcus multilocularis	smad	0.0008	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0241	0.078
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0147	0.0584
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0021	0.0178	0.0937
Schistosoma mansoni	cpg binding protein	0.0059	0.0665	0.0665
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.0136	0.0135
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0021	0.0178	0.0464
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0825	0.2672
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0112	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0825	0.2677
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0249	0.3081	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0021	0.0178	0.0119
Schistosoma mansoni	hypothetical protein	0.0165	0.2005	0.2005
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0021	0.0178	0.0119
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0021	0.0178	0.0464
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0112	0.0361
Echinococcus granulosus	geminin	0.0165	0.2005	0.2005
Brugia malayi	T-complex protein 1, beta subunit	0.0024	0.0224	0.0727
Trichomonas vaginalis	conserved hypothetical protein	0.0205	0.2513	0.8157
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0021	0.0178	0.0464
Schistosoma mansoni	Smad4	0.0008	0.0017	0.0017
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0395	0.1049
Echinococcus granulosus	GPCR family 2	0.0031	0.0305	0.0305
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0021	0.0178	0.0464
Echinococcus granulosus	cytochrome P450 2K1	0.0021	0.0178	0.0178
Trichomonas vaginalis	glucosylceramidase, putative	0.0164	0.1993	0.6465
Schistosoma mansoni	hypothetical protein	0.0165	0.2005	0.2005
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0021	0.0178	0.0464
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0825	0.1272
Toxoplasma gondii	ABC1 family protein	0.0072	0.0825	0.2971
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0021	0.0178	0.0119
Schistosoma mansoni	hypothetical protein	0.0066	0.0757	0.0757
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0224	0.0224
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0825	0.1272
Loa Loa (eye worm)	cytochrome P450	0.0021	0.0178	0.0578
Onchocerca volvulus		0.0072	0.0825	0.1466
Echinococcus granulosus	Smad4	0.0008	0.0017	0.0017
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0077	0.0241
Trichomonas vaginalis	glucosylceramidase, putative	0.0249	0.3081	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0021	0.0178	0.0119

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.9 uM	Inhibition of human recombinant MIF tautomerase activity using 4-hydroxyphenylpyruvate as substrate	ChEMBL.	21719283

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1807941

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1022737