Detailed information for compound 1040452

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 688.507 | Formula: C29H24F12N4O2
  • H donors: 3 H acceptors: 4 LogP: 5.67 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNCCN(CC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)O)CC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)O
  • InChi: 1S/C29H24F12N4O2/c1-42-8-9-45(12-20(46)16-10-22(28(36,37)38)43-24-14(16)4-2-6-18(24)26(30,31)32)13-21(47)17-11-23(29(39,40)41)44-25-15(17)5-3-7-19(25)27(33,34)35/h2-7,10-11,20-21,42,46-47H,8-9,12-13H2,1H3
  • InChiKey: WXDAOZFUGCCMAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0254 0.0313
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0017 0.011
Brugia malayi serine/threonine-protein kinase plk-2 0.0209 0.2748 0.2748
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0017 0.2359
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0228 0.3016 0.3717
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0055 0.0126
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0206 0.1333
Leishmania major cytochrome p450-like protein 0.0032 0.0206 0.0682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0055 0.0055
Loa Loa (eye worm) aspartyl aminopeptidase 0.0228 0.3016 0.3016
Mycobacterium tuberculosis Probable reductase 0.0127 0.1572 0.4104
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0065 0.0675 0.0675
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.1572 0.4104
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1289 0.1589
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1289 0.2988
Entamoeba histolytica Ran family GTPase 0.0022 0.0054 0.0067
Entamoeba histolytica serine/threonine protein kinase, putative 0.0209 0.2748 0.3387
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0055 0.0055
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0206 0.0682
Leishmania major GTP-binding protein, putative 0.0022 0.0054 0.0179
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0054 0.0054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0055 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0055 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0055 0.0055
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0419 0.0971
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.1544 0.3579
Entamoeba histolytica hypothetical protein 0.0023 0.0072 0.0089
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0158 0.0522
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0254 0.0254
Onchocerca volvulus 0.0047 0.0419 0.0512
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0206 0.0537
Brugia malayi nuclear hormone receptor 0.0022 0.0055 0.0055
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0254 0.0313
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.1572 0.4104
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0206 0.0537
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.1544 0.512
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0055 0.0126
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0055 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0017 0.0021
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0158 0.102
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0206 0.0537
Echinococcus granulosus aspartyl aminopeptidase 0.0228 0.3016 0.699
Echinococcus granulosus importin subunit beta 1 0.003 0.0167 0.0388
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0419 0.0971
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.8114 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0242 0.0802
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0206 0.0537
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0209 0.2748 0.2748
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0072 0.0188
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0242 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0206 0.0537
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0072 0.0467
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0228 0.3016 0.3717
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0242 0.0632
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0055 0.0055
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0206 0.0477
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0017 0.0044
Onchocerca volvulus 0.0517 0.7173 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0055 0.0055
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0206 0.0537
Onchocerca volvulus 0.0093 0.1083 0.1445
Brugia malayi Cytochrome P450 family protein 0.0112 0.1344 0.1344
Loa Loa (eye worm) beta-lactamase 0.0035 0.0242 0.0242
Echinococcus multilocularis aspartyl aminopeptidase 0.0228 0.3016 0.699
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1289 0.1589
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1289 0.1289
Echinococcus multilocularis snurportin 1 0.0318 0.4315 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0086 0.0106
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0513 0.0513
Trypanosoma brucei polo-like protein kinase 0.0209 0.2748 0.9112
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0017 0.0056
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0209 0.2748 0.9112
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0589 0.1952
Brugia malayi Cytochrome P450 family protein 0.0032 0.0206 0.0206
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0206 0.0537
Giardia lamblia Kinase, PLK 0.0209 0.2748 0.3387
Schistosoma mansoni importin beta-1 0.003 0.0167 0.0388
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0017 0.0056
Leishmania major importin beta-1 subunit, putative 0.0024 0.0086 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.1275 0.1571
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1289 0.4275
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0055 0.0126
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.1344 0.1344
Schistosoma mansoni hypothetical protein 0.0175 0.2258 0.5232
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0419 0.0419
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0055 0.0126
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0513 0.119
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0086 0.0286
Treponema pallidum fructose-bisphosphate aldolase 0.0582 0.8114 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0017 0.0039
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0206 0.0537
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0242 0.0561
Schistosoma mansoni hypothetical protein 0.0175 0.2258 0.5232
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0206 0.0537
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0055 0.0126
Loa Loa (eye worm) cytochrome P450 0.0032 0.0206 0.0206
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0206 0.0537
Plasmodium falciparum thioredoxin reductase 0.0056 0.0542 0.1798
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0542 0.1256
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0254 0.0313
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0158 0.102
Trichomonas vaginalis set domain proteins, putative 0.0517 0.7173 0.884
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0242 0.0298
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0158 0.0522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0206 0.0682
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0055 0.0126
Onchocerca volvulus 0.0035 0.0242 0.0263
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.1544 0.3579
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0055 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0055 0.0055
Plasmodium vivax glutathione reductase, putative 0.0056 0.0542 0.1798
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0055 0.0055
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.2063 0.4781
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1544 0.4032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.627 0.627
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.1572 0.4104
Brugia malayi mbt repeat family protein 0.0047 0.0419 0.0419
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0055 0.0126
Leishmania major trypanothione reductase 0.0056 0.0542 0.1798
Brugia malayi steroid hormone receptor 0.0022 0.0055 0.0055
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1544 0.3579
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0054 0.0179
Leishmania major cytochrome p450-like protein 0.0032 0.0206 0.0682
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0318 0.4315 1
Brugia malayi 6-phosphofructokinase 0.0108 0.1289 0.1289
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0228 0.3016 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Schistosoma mansoni kinase 0.0106 0.1268 0.2939
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0072 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0072 0.0089
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0072 0.3925
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0242 0.0632
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0254 0.0843
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0206 0.0537
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0228 0.3016 0.3717
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0542 0.0542
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0017 0.0056
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0206 0.0537
Mycobacterium leprae putative cytochrome p450 0.0032 0.0206 0.0356
Loa Loa (eye worm) glutathione reductase 0.0056 0.0542 0.0542
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1289 0.1589
Loa Loa (eye worm) hypothetical protein 0.0054 0.0513 0.0513
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0054 0.0179
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0017 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Mycobacterium tuberculosis Conserved protein 0.0035 0.0242 0.0632
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0017 0.0021
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1289 0.1289
Toxoplasma gondii thioredoxin reductase 0.0056 0.0542 0.3511
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0158 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0054 0.0179
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0542 0.1256
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0589 0.0589
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0242 0.0632
Plasmodium falciparum glutathione reductase 0.0019 0.0017 0.0056
Trypanosoma brucei trypanothione reductase 0.0056 0.0542 0.1798
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0158 0.0194
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.4315 0.4315
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Loa Loa (eye worm) MBCTL1 0.0054 0.0513 0.0513
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0055 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0254 0.0843
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0242 0.0298
Brugia malayi Importin beta-1 subunit 0.003 0.0167 0.0167
Trypanosoma brucei glucosidase, putative 0.0036 0.0254 0.0843
Leishmania major hypothetical protein, conserved 0.0035 0.0242 0.0802
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0206 0.0537
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1544 0.3579
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0675 0.1565
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0242 0.0632
Echinococcus multilocularis geminin 0.0175 0.2258 0.5232
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.0228 0.3016 0.3016
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.2473 0.5732
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0925 0.2143
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0017 0.0056
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0419 0.0971
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0206 0.0537
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1289 0.4275
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0242 0.0632
Mycobacterium tuberculosis Conserved protein 0.0035 0.0242 0.0632
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0419 0.0971
Schistosoma mansoni hypothetical protein 0.0032 0.0206 0.0477
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0158 0.0194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0254 0.0313
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0107 0.1275 0.1571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0206 0.0537
Loa Loa (eye worm) hypothetical protein 0.0228 0.3016 0.3016
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1228 0.1514
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0206 0.0537
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0242 0.0561
Brugia malayi beta-lactamase family protein 0.0035 0.0242 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Entamoeba histolytica aminopeptidase, putative 0.0228 0.3016 0.3717
Plasmodium vivax importin-beta 2, putative 0.003 0.0167 0.0554
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0254 0.0313
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.1572 0.3991
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0254 0.0254
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0158 0.0194
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0228 0.3016 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0054 0.0179
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2063 0.4781
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0017 0.0056
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0054 0.0054
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1289 0.2988
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0513 0.119
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0513 0.119
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.1275 0.1571
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0055 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0055 0.0055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2955 0.7715
Leishmania major cytochrome p450-like protein 0.0059 0.0589 0.1952
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0254 0.0313
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0713 1 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0419 0.0971
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0206 0.0537
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0242 0.0802
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0072 0.0239
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0675 0.1565
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0017 0.011
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0072 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1228 0.1514
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0242 0.0298
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1289 0.2988
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0017 0.0044
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0107 0.1275 0.1571
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0284 0.383 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0206 0.0537
Brugia malayi 6-phosphofructokinase 0.0108 0.1289 0.1289
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0242 0.0561
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.2748 0.6369
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1544 0.4032
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0925 0.0925
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0209 0.2748 0.6369
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0055 0.0126
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0055 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0206 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0055 0.0055
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0158 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0589 0.1952
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0122
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0228 0.3016 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0055 0.0126
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0072 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0055 0.0055
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0206 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0675 0.1565
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0589 0.0589
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0589 0.1538
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1289 0.3367
Brugia malayi ecdysteroid receptor 0.0022 0.0055 0.0055
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0167 0.1083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0675 0.1565
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0055 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0206 0.0537
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0419 0.0971
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1544 0.4032
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0055 0.0126
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0167 0.0554
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0142 0.1776 0.4638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1289 0.1589
Mycobacterium ulcerans lipase LipD 0.0035 0.0242 0.0632
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0054 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0242 0.0802
Plasmodium falciparum glutathione reductase 0.0056 0.0542 0.1798
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0167 0.0554
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0419 0.0419
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0017 0.0039
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0055 0.0126
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0242 0.0632
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0589 0.1952
Brugia malayi Cytochrome P450 family protein 0.0059 0.0589 0.0589
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0072 0.0239
Brugia malayi Aspartyl aminopeptidase 0.0228 0.3016 0.3016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0055 0.0055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0082 0.0925 0.0925
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0206 0.0537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0242 0.0561
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0206 0.0682
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0055 0.0126
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0254 0.0589
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0206 0.0537
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0086 0.0106
Mycobacterium tuberculosis Conserved protein 0.0035 0.0242 0.0632
Onchocerca volvulus 0.0035 0.0242 0.0263
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0513 0.119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0641 0.1485
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0206 0.0537
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0542 0.1798
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0242 0.0802
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0158 0.0194
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Mycobacterium tuberculosis Probable oxidoreductase 0.0142 0.1776 0.4638
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0542 0.1798
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0017 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0055 0.0126
Brugia malayi phosphofructokinase 0.0108 0.1289 0.1289
Brugia malayi Cytochrome P450 family protein 0.0059 0.0589 0.0589
Onchocerca volvulus 0.0035 0.0242 0.0263
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0419 0.0512
Brugia malayi cytochrome P450 0.0032 0.0206 0.0206
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0242 0.0632
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0055 0.0126
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0513 0.119
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0054 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0206 0.0537
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0242 0.0452
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1289 0.1589
Trichomonas vaginalis hypothetical protein 0.0107 0.1275 0.1571
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0206 0.0682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0055 0.0055
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0228 0.3016 0.3717
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.1544 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2063 0.4781
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0206 0.0537
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0254 0.1647
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1289 0.1289
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0142 0.1776 0.4535
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0284 0.383 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1289 0.1589
Toxoplasma gondii ABC1 family protein 0.0035 0.0242 0.1567
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0017 0.0056
Echinococcus multilocularis importin subunit beta 1 0.003 0.0167 0.0388
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2748 0.9112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0228 0.3016 1
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1289 0.2988
Mycobacterium ulcerans hypothetical protein 0.0035 0.0242 0.0632
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0055 0.0126
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0158 0.0522
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.2063 0.2063
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.2063 0.2063
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1289 0.3367
Trichomonas vaginalis ran, putative 0.0022 0.0054 0.0067
Trichomonas vaginalis esterase, putative 0.0035 0.0242 0.0298
Schistosoma mansoni cytochrome P450 0.0032 0.0206 0.0477
Echinococcus multilocularis 0.0032 0.0206 0.0477
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0242 0.0298
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.1572 0.4104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0675 0.4374
Schistosoma mansoni ran 0.0022 0.0054 0.0125
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0542 0.1416
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0206 0.0537
Schistosoma mansoni alpha-glucosidase 0.0139 0.1739 0.4031
Plasmodium falciparum thioredoxin reductase 0.0019 0.0017 0.0056
Schistosoma mansoni alpha-glucosidase 0.0139 0.1739 0.4031
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0228 0.3016 0.7876
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0242 0.0298
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0206 0.0537
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0206 0.0537
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1289 0.4275
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0086 0.0106
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0419 0.0971
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0206 0.0537
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0054 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0055 0.0055
Treponema pallidum NADH oxidase 0.0019 0.0017 0.0021
Schistosoma mansoni ran 0.0022 0.0054 0.0125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0055 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0675 0.1565
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2748 0.9112
Entamoeba histolytica hypothetical protein 0.0024 0.0086 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0055 0.0055
Brugia malayi beta-lactamase family protein 0.0035 0.0242 0.0242
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0206 0.0537
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0228 0.3016 0.699
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0925 0.2143
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0228 0.3016 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0254 0.0589
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0072 0.0239
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0022 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0675 0.1565
Schistosoma mansoni coup transcription factor 0.0022 0.0055 0.0126
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0055 0.0126
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.1572 0.4104
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0925 0.2143
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0254 0.0313
Mycobacterium ulcerans beta-lactamase 0.0035 0.0242 0.0632
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0017 0.2359
Schistosoma mansoni alpha glucosidase 0.0036 0.0254 0.0589
Brugia malayi mbt repeat family protein 0.0047 0.0419 0.0419
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0206 0.0356
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.2473 0.5732
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0158 0.0194
Mycobacterium leprae Probable lipase LipE 0.0035 0.0242 0.0452
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0675 0.1565
Brugia malayi Pre-SET motif family protein 0.0454 0.627 0.627
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0017 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0017 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0254 0.0843
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0242 0.0242
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0142 0.1776 0.4638
Onchocerca volvulus 0.0065 0.0675 0.0872
Brugia malayi RNA, U transporter 1 0.0085 0.0958 0.0958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0055 0.0055
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0017 0.0056
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0055 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0055 0.0055
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0209 0.2748 0.6369
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0206 0.0537
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0228 0.3016 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0206 0.0537
Echinococcus granulosus geminin 0.0175 0.2258 0.5232
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0242 0.0632
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0228 0.3016 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0055 0.0055
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0254 0.0313
Brugia malayi glutathione reductase 0.0056 0.0542 0.0542
Onchocerca volvulus 0.0082 0.0925 0.1223
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0284 0.383 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0055 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1289 0.1589
Schistosoma mansoni hypothetical protein 0.0291 0.3929 0.9104
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1289 0.1589
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0206 0.0537
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0254 0.0313
Echinococcus granulosus snurportin 1 0.0318 0.4315 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.1544 0.4032
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0206 0.0537
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0242 0.0632
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0072 0.0188
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0017 0.0056
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0158 0.0194
Onchocerca volvulus Serine\/threonine kinase homolog 0.0209 0.2748 0.3785
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0206 0.0537
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0158 0.0194
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0228 0.3016 0.7835
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0055 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0206 0.0537
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0158 0.0194
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0206 0.0537
Brugia malayi nuclear receptor NHR-88 0.0022 0.0055 0.0055
Brugia malayi Pre-SET motif family protein 0.0065 0.0675 0.0675
Brugia malayi Thioredoxin reductase 0.0056 0.0542 0.0542
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0158 0.102
Brugia malayi beta-lactamase 0.0035 0.0242 0.0242
Plasmodium falciparum importin beta, putative 0.003 0.0167 0.0554
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0254 0.0313
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.8114 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0055 0.0055
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0055 0.0126
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0017 0.0039
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0254 0.0313
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0072 0.0188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.8114 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0206 0.0537
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0158 0.0522
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0055 0.0055
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0107 0.1275 0.1571
Giardia lamblia Fructose-bisphosphate aldolase 0.0582 0.8114 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0167
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0158 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.1275 0.1571
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0055 0.0126
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0206 0.0537
Plasmodium vivax SET domain protein, putative 0.0065 0.0675 0.2239
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0054 0.0125
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0054 0.035
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2748 0.3387
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0206 0.0682
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1289 0.3239
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0158 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0055 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0055 0.0126
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0228 0.3016 0.699
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0017 0.0056

Activities

Activity type Activity value Assay description Source Reference
IC90 (functional) = 22 ng/ml Antimalarial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6 by SYBR Green I-based fluorescence assay ChEMBL. 21854078
IC90 (functional) = 30 ng/ml Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM91C235 by SYBR Green I-based fluorescence assay ChEMBL. 21854078

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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