Detailed information for compound 1063204

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.379 | Formula: C18H24O7
  • H donors: 2 H acceptors: 4 LogP: 0.31 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1(CO)[C@@H]2OCO[C@@]32[C@](C1=O)(C)[C@@H]1OC(=O)C(=C)[C@@H]1CC[C@@H]3C
  • InChi: 1S/C18H24O7/c1-9-4-5-11-10(2)13(21)25-12(11)16(3)14(22)17(6-19,7-20)15-18(9,16)24-8-23-15/h9,11-12,15,19-20H,2,4-8H2,1,3H3/t9-,11-,12+,15-,16+,18-/m0/s1
  • InChiKey: IKRDODCFBMBHOZ-CGODKZNHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Onchocerca volvulus 0.004 0.0048 0.0869
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0032 0.0359
Trypanosoma brucei protein kinase, putative 0.0114 0.0176 0.1505
Schistosoma mansoni hypothetical protein 0.0023 0.0017 0.0184
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.141
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0008 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.01 0.01
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0017 0.0017
Plasmodium vivax hypothetical protein, conserved 0.004 0.0048 0.3824
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0391 0.0391
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0062 0.0817
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0085 0.0085
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0043
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0048 0.0448
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0371 0.5488
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.004 0.004
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.008 0.0117 0.1724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0094 0.0141 0.0396
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0048 0.0702
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.01 0.096
Echinococcus multilocularis GPCR, family 2 0.0031 0.0031 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0094 0.1394
Loa Loa (eye worm) hypothetical protein 0.0061 0.0083 0.1227
Loa Loa (eye worm) hypothetical protein 0.0062 0.0085 0.1257
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0243 0.0243
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0398 0.5895
Echinococcus granulosus serine protein kinase ATM 0.0225 0.0371 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0111 0.141
Brugia malayi Pre-SET motif family protein 0.0217 0.0357 0.5283
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0008 0.0039
Entamoeba histolytica hypothetical protein 0.0077 0.0111 0.141
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0316 0.0531 0.4608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0111 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0111 0.1643
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0425 0.0721 1
Echinococcus granulosus cpg binding protein 0.0033 0.0035 0.0035
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0008 0.0039
Entamoeba histolytica hypothetical protein 0.0026 0.0023 0.0065
Entamoeba histolytica hypothetical protein 0.0225 0.0371 0.5362
Entamoeba histolytica hypothetical protein 0.008 0.0117 0.1493
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.0583 0.8629
Leishmania major phosphatidylinositol 3-kinase, putative 0.0399 0.0675 0.1858
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0077 0.0111 0.0308
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0021 0.0013 0.0132
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0391 0.5393
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0029 0.0029
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0399 0.0675 0.0675
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0048 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0048 0.0126
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0077 0.0111 0.0937
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0077 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0067 0.0094 0.1394
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.141
Schistosoma mansoni hypothetical protein 0.0031 0.0031 0.0381
Leishmania major phosphatidylinositol 4-kinase, putative 0.0077 0.0111 0.0297
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0077 0.0111 0.0111
Echinococcus granulosus peregrin 0.0032 0.0033 0.0033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0399 0.0675 0.193
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0176 0.24
Echinococcus multilocularis mitogen activated protein kinase 0.0114 0.0176 0.0176
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0148 0.0236 0.0668
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0029 0.0427
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0033 0.0378
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0048 0.0448
Entamoeba histolytica hypothetical protein 0.008 0.0117 0.1493
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0077 0.0111 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.0111 0.1756
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0399 0.0675 0.1858
Schistosoma mansoni ran 0.0024 0.0018 0.0204
Brugia malayi MH2 domain containing protein 0.0126 0.0197 0.2922
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0225 0.0371 0.3204
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0399 0.0675 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Onchocerca volvulus 0.003 0.0029 0.04
Plasmodium vivax hypothetical protein, conserved 0.003 0.0029 0.203
Brugia malayi isocitrate dehydrogenase 0.0018 0.0008 0.0119
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0399 0.0675 0.1858
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0008 0.0119
Echinococcus granulosus geminin 0.0176 0.0285 0.0285
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0048 0.0671
Echinococcus multilocularis cpg binding protein 0.0033 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.0281 0.4001
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0111 0.0111
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0018 0.0995
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0399 0.0675 0.5865
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0079 0.0079
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0077 0.0111 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0048 0.0671
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0023 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0197 0.2922
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0111 0.1495
Schistosoma mansoni zinc finger protein 0.0021 0.0014 0.0147
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0111 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.0236 0.3316
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0077 0.0111 0.141
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0111 1
Schistosoma mansoni rab6-interacting 0.0021 0.0013 0.013
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0077 0.0111 0.141
Brugia malayi follicle stimulating hormone receptor 0.024 0.0398 0.5895
Trichomonas vaginalis PIKK family atypical protein kinase 0.025 0.0416 0.6048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0077 0.0111 0.1495
Loa Loa (eye worm) hypothetical protein 0.025 0.0416 0.6155
Onchocerca volvulus 0.0077 0.0111 0.2473
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0148 0.0236 0.3497
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0174 0.0281 0.0281
Echinococcus granulosus mitogen activated protein kinase 3 0.0114 0.0176 0.0176
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0114 0.0176 0.0495
Brugia malayi Doublecortin family protein 0.0021 0.0013 0.0192
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0316 0.0531 0.1516
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0111 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0077 0.0111 0.0308
Onchocerca volvulus 0.004 0.0048 0.0869
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0048 0.0382
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0048 0.0676
Trypanosoma cruzi hypothetical protein, conserved 0.2001 0.3482 1
Schistosoma mansoni lipoxygenase 0.0058 0.0079 0.1045
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0077 0.0111 0.0308
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0008 0.0013
Onchocerca volvulus 0.0032 0.0032 0.0481
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0399 0.0675 0.0675
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0111 0.141
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0399 0.0675 0.5865
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0029 0.0029
Leishmania major phosphatidylinositol kinase related protein, putative 0.0077 0.0111 0.0297
Echinococcus multilocularis mitogen activated protein kinase 3 0.0114 0.0176 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Schistosoma mansoni hypothetical protein 0.003 0.0029 0.0353
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0033 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0111 0.1643
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0085 0.1257
Toxoplasma gondii hypothetical protein 0.0108 0.0166 0.2361
Mycobacterium tuberculosis Conserved protein 0.004 0.0048 0.0671
Loa Loa (eye worm) hypothetical protein 0.0071 0.0102 0.1508
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0111 0.1643
Brugia malayi Importin beta-1 subunit 0.0032 0.0033 0.0493
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0077 0.0111 0.0937
Entamoeba histolytica hypothetical protein 0.0077 0.0111 0.141
Echinococcus multilocularis lamin 0.0062 0.0085 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0047 0.0595
Leishmania major hypothetical protein, conserved 0.2077 0.3617 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0077 0.0111 0.0308
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0114 0.0176 0.2606
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0077 0.0111 0.0308
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0048 0.5
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0008 0.0119
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0399 0.0675 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0029 0.0427
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.0177 0.0499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0149 0.22
Entamoeba histolytica protein kinase rad3, putative 0.0225 0.0371 0.5362
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0077 0.0111 0.0297
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0008 0.0062
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.025 0.0416 0.3597
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0077 0.0111 0.0111
Brugia malayi Bromodomain containing protein 0.0078 0.0113 0.1664
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0008 0.0013
Entamoeba histolytica hypothetical protein 0.008 0.0117 0.1493
Giardia lamblia GTOR 0.0399 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0045 0.0659
Onchocerca volvulus 0.0062 0.0085 0.1815
Echinococcus multilocularis zinc finger protein 0.0021 0.0014 0.0014
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0114 0.0176 0.0495
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0077 0.0111 0.1495
Plasmodium vivax SET domain protein, putative 0.0032 0.0032 0.2329
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0048 0.0443
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0111 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0033 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Schistosoma mansoni ap endonuclease 0.0041 0.0048 0.0614
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0702
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0115
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0083 0.1272
Onchocerca volvulus 0.0247 0.0409 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0048 0.0443
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.0111 0.141
Trypanosoma cruzi target of rapamycin kinase 3 0.0399 0.0675 0.193
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0111 0.0111
Leishmania major hypothetical protein, conserved 0.0051 0.0067 0.0174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0048 0.0671
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0111 0.1495
Loa Loa (eye worm) hypothetical protein 0.0098 0.0149 0.22
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0176 0.24
Schistosoma mansoni hypothetical protein 0.0176 0.0285 0.3922
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0083 0.0644
Echinococcus multilocularis serine protein kinase ATM 0.0225 0.0371 0.0371
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0029 0.0429
Echinococcus granulosus dnaJ subfamily B 0.0425 0.0721 0.0721
Schistosoma mansoni intermediate filament proteins 0.0062 0.0085 0.1132
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0192
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0399 0.0675 0.1858
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0077 0.0111 0.1643
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0048 0.0671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0149 0.22
Plasmodium vivax importin-beta 2, putative 0.0032 0.0033 0.2452
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0076 0.1118
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0148 0.0148
Echinococcus granulosus muscleblind protein 0.0152 0.0243 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Leishmania major importin beta-1 subunit, putative 0.0026 0.0023 0.0052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.01 0.1567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0391 0.0391
Echinococcus granulosus zinc finger protein 0.0021 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0067 0.0094 0.1261
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0176 0.2401
Plasmodium falciparum phd finger protein, putative 0.003 0.0029 0.203
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0048 0.3853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0391 0.5393
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0048 0.0706
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0018 0.0995
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0029 0.0353
Entamoeba histolytica hypothetical protein 0.008 0.0117 0.1493
Brugia malayi intermediate filament protein 0.0062 0.0085 0.1257
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0008 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0031 0.0458
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.0111 0.141
Giardia lamblia Phosphatidylinositol 4-kinase 0.0077 0.0111 0.141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.0429 0.7192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Schistosoma mansoni polycystin 1-related 0.0021 0.0013 0.013
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0077 0.0111 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0067 0.5666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0111 0.1542
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0371 0.5488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0391 0.5393
Giardia lamblia Kinase, CMGC MAPK 0.0114 0.0176 0.24
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0048 0.3853
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0399 0.0675 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0077 0.0111 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0023 0.0065
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0399 0.0675 0.193
Loa Loa (eye worm) phosphatidylinositol 3 0.0399 0.0675 1
Schistosoma mansoni hypothetical protein 0.0176 0.0285 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Brugia malayi beta-lactamase 0.004 0.0048 0.0702
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0077 0.0111 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0111 0.1542
Entamoeba histolytica hypothetical protein 0.0077 0.0111 0.141
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0031 0.0458
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0079 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0391 0.0391
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0018 0.0042
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0083 0.11
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0048 0.0443
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0047 0.0595
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.01 0.1376
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0702
Brugia malayi hypothetical protein 0.0021 0.0013 0.0192
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0048 0.0702
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0117 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0176 0.24
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0669 0.1148 0.329
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0399 0.0675 0.5865
Loa Loa (eye worm) hypothetical protein 0.0152 0.0243 0.3601
Mycobacterium tuberculosis Conserved protein 0.004 0.0048 0.0671
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.0983
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0048 0.0126
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0174 0.0281 0.0281
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0035 0.0511
Onchocerca volvulus Alhambra homolog 0.003 0.0029 0.0403
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0047 0.0686
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0077 0.0111 0.141
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0111 0.1643
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.0391 0.5787
Echinococcus multilocularis musashi 0.0062 0.0085 0.0085
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0399 0.0675 0.5865
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0111 0.1643
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0048 0.0122
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0018 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0702
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0085 0.1256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0493
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0031 0.0031
Leishmania major hypothetical protein, unknown function 0.0077 0.0111 0.0297
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0077 0.0111 0.141
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0077 0.0111 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0077 0.0111 0.1643
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0013 0.0013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0114 0.0176 0.0477
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0458
Mycobacterium ulcerans hypothetical protein 0.0352 0.0594 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0702
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0111 0.141
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0111 0.141
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.01 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0416 0.6048
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0399 0.0675 0.0675
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0009 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0085 0.1257
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0043
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0225 0.0371 0.5362
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0399 0.0675 0.193
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.004 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0048 0.0127
Brugia malayi jmjC domain containing protein 0.004 0.0047 0.0686
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0067 0.5666
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0391 0.0391
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0048 0.0048
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0077 0.0111 0.0111
Brugia malayi hypothetical protein 0.0033 0.0035 0.0511
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0426
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0029 0.0029
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0048 0.0005
Echinococcus multilocularis RUN 0.0021 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0062 0.0817
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0018 0.0018
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0083 0.0083
Echinococcus granulosus RUN 0.0021 0.0013 0.0013
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0111 0.141
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0067 0.018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0148 0.0148
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0113 0.1523
Echinococcus granulosus importin subunit beta 1 0.0032 0.0033 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0045 0.0055 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0077 0.0111 0.141
Loa Loa (eye worm) hypothetical protein 0.0225 0.0371 0.5488
Brugia malayi Bromodomain containing protein 0.0039 0.0045 0.0657
Schistosoma mansoni lipoxygenase 0.0021 0.0013 0.013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0083 0.0644
Schistosoma mansoni hypothetical protein 0.008 0.0117 0.1571
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0077 0.0111 0.1495
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.002 0.022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0031 0.0031
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.002 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0399 0.0675 1
Leishmania major hypothetical protein, conserved 0.004 0.0048 0.0121
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0018 0.0271
Leishmania major phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.0297
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0077 0.0111 0.0308
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.141
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0114 0.0176 0.0477
Schistosoma mansoni cpg binding protein 0.003 0.0029 0.0351
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0048 0.0671
Brugia malayi hypothetical protein 0.0051 0.0067 0.0983
Leishmania major GTP-binding protein, putative 0.0024 0.0018 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Onchocerca volvulus 0.004 0.0048 0.0869
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0018 0.0271
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.141
Echinococcus multilocularis Zinc finger, PHD finger 0.0077 0.0111 0.0111
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.572 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0111 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.005 0.005
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0077 0.0111 0.0937
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0085 0.0085
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0111 0.1542
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0048 0.0443
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0023 0.0065
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.01 0.0266
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.0111 0.141
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0225 0.0371 0.1054
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0013 0.0477
Schistosoma mansoni loxhd1 0.0021 0.0013 0.013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Brugia malayi RNA, U transporter 1 0.0092 0.0138 0.2043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0141 0.0396
Brugia malayi FAT domain containing protein 0.0174 0.0281 0.4164
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0399 0.0675 1
Schistosoma mansoni ran 0.0024 0.0018 0.0204
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0077 0.0111 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0048 0.0443
Leishmania major mitochondrial DNA polymerase beta 0.0669 0.1148 0.3168
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0013 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0149 0.22
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0236 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Brugia malayi PHD-finger family protein 0.003 0.0029 0.0429
Brugia malayi beta-lactamase family protein 0.004 0.0048 0.0702
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0031 0.0458
Plasmodium falciparum importin beta, putative 0.0032 0.0033 0.2452
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0067 0.0548
Schistosoma mansoni hypothetical protein 0.0031 0.0031 0.0381
Toxoplasma gondii ABC1 family protein 0.004 0.0048 0.059
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0077 0.0111 0.0308
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0048 0.0048
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0669 0.1148 0.329
Echinococcus multilocularis geminin 0.0176 0.0285 0.0285
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0031 0.0031 0.0381
Echinococcus granulosus intermediate filament protein 0.0062 0.0085 0.0085
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.0176 0.0495
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0021 0.0013 0.013
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0077 0.0111 0.0111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0111 0.1643
Schistosoma mansoni cpg binding protein 0.0033 0.0035 0.044
Schistosoma mansoni ap endonuclease 0.0041 0.0048 0.0614
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0176 0.24
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.0111 0.1495
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0702
Echinococcus granulosus lamin 0.0062 0.0085 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0048 0.0127
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0399 0.0675 0.9355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Echinococcus multilocularis muscleblind protein 0.0152 0.0243 0.0243
Toxoplasma gondii FATC domain-containing protein 0.0225 0.0371 0.5434
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0032 0.0396
Loa Loa (eye worm) hypothetical protein 0.0174 0.0281 0.4164
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0048 0.0671
Leishmania major phosphatidylinositol kinase, putative 0.0077 0.0111 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Trichomonas vaginalis esterase, putative 0.004 0.0048 0.0443
Onchocerca volvulus 0.0062 0.0085 0.1815
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0067 0.018
Brugia malayi Pre-SET motif family protein 0.0032 0.0032 0.0474
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0669 0.1148 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0111 0.1643
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0114 0.0176 0.1505
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0048 0.061
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.01 0.096
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0192
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.0111 0.141
Schistosoma mansoni lamin 0.0062 0.0085 0.1132
Schistosoma mansoni hypothetical protein 0.0031 0.0031 0.0381
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0111 0.1643
Onchocerca volvulus 0.0077 0.0111 0.2473
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0067 0.5666
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0111 0.1542
Loa Loa (eye worm) beta-lactamase 0.004 0.0048 0.0702
Schistosoma mansoni rab6-interacting 0.0021 0.0013 0.013
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0077 0.0111 0.0308
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0077 0.0111 0.1495
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0117 0.1571
Brugia malayi PHD-finger family protein 0.0027 0.0024 0.035
Loa Loa (eye worm) phosphatidylinositol 3 0.0399 0.0675 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0048 0.0671
Echinococcus multilocularis peregrin 0.0032 0.0033 0.0033
Giardia lamblia PHD finger protein 15 0.003 0.0029 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Plasmodium vivax hypothetical protein 0.0077 0.0111 1
Schistosoma mansoni cpg binding protein 0.0033 0.0035 0.044
Schistosoma mansoni importin beta-1 0.0032 0.0033 0.0413
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.01 0.096
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0035 0.0511
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0397
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0048 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0082 0.1105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0062 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0111 0.1643
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0048 0.0671
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0029 0.0029
Schistosoma mansoni bromodomain containing protein 0.0066 0.0092 0.1226
Entamoeba histolytica hypothetical protein 0.0077 0.0111 0.141
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0225 0.0371 0.0371
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0083 0.1223
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0018 0.0128
Echinococcus granulosus snurportin 1 0.0346 0.0583 0.0583
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0032 0.0032
Brugia malayi Bromodomain containing protein 0.0032 0.0033 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0243 0.3601
Echinococcus granulosus lamin dm0 0.0062 0.0085 0.0085
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0013 0.0192
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0013 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0721
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0077 0.0111 0.0937
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0077 0.0111 0.1643
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.0141 0.0396
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0399 0.0675 0.5865
Toxoplasma gondii non-specific serine/threonine protein kinase 0.025 0.0416 0.6108
Echinococcus granulosus jumonji domain containing protein 0.0042 0.005 0.005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.1437 0.1437
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0316 0.0531 0.146
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0702
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.0111 0.141
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0399 0.0675 0.9355
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0015 0.0222
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0018 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0048 0.0448
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.009 0.1196
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0399 0.0675 0.1858
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0029 0.0029
Echinococcus granulosus GPCR family 2 0.0031 0.0031 0.0031
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0077 0.0111 0.141
Loa Loa (eye worm) hypothetical protein 0.0077 0.0111 0.1643
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0077 0.0111 0.0308
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0357 0.5283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0111 0.141
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.0176 0.0495
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0083 0.0219
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0048 0.0048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0048 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.0391 0.5787
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0225 0.0371 0.0371
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0077 0.0111 0.141
Schistosoma mansoni hypothetical protein 0.0174 0.0281 0.3866
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0023 0.0065
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0013 0.0013
Brugia malayi hypothetical protein 0.0021 0.0013 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0077 0.0111 0.141
Brugia malayi jmjC domain containing protein 0.0098 0.0148 0.2196
Schistosoma mansoni lamin 0.0062 0.0085 0.1132
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0111 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.01 0.1341
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.141
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0399 0.0675 0.193
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0409 0.5949
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0225 0.0371 0.5111
Brugia malayi beta-lactamase family protein 0.004 0.0048 0.0702
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0077 0.0111 0.141
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0094 0.0141 0.1203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0032 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0048 0.0706
Brugia malayi MAP kinase sur-1 0.0114 0.0176 0.2606
Echinococcus multilocularis 0.0077 0.0111 0.0111
Toxoplasma gondii target of rapamycin (TOR), putative 0.0399 0.0675 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Echinococcus multilocularis snurportin 1 0.0346 0.0583 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0371 0.5362
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0114 0.0176 0.2517
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0085 0.1257
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0397
Echinococcus granulosus mitogen activated protein kinase 0.0114 0.0176 0.0176
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0029 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0399 0.0675 1
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0067 0.0874
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0111 0.141
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0197 0.2922
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0031 0.0031
Brugia malayi Muscleblind-like protein 0.0152 0.0243 0.3601
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0048 0.061
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0062 0.0922
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0111 0.1542
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0077 0.0111 0.0937
Schistosoma mansoni hypothetical protein 0.0346 0.0583 0.8066
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0077 0.0111 1
Echinococcus multilocularis lamin dm0 0.0062 0.0085 0.0085
Toxoplasma gondii exonuclease III APE 0.0041 0.0048 0.0594
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0225 0.0371 0.1054
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0029 0.0313
Giardia lamblia Hypothetical protein 0.0077 0.0111 0.141
Schistosoma mansoni fkbp-rapamycin associated protein 0.0225 0.0371 0.5111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0352 0.0594 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0111 0.1643
Schistosoma mansoni hypothetical protein 0.0077 0.0111 0.1495
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0033 0.0259

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2.61 % Induction of apoptosis in human HL60 cells assessed as DNA population at sub G0/G1 phase at 10 uM after 6 hrs by flow cytometry ChEMBL. 19501509
IC50 (functional) = 17 uM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19501509
IC50 (functional) = 70 uM Cytotoxicity against human HeLa cells after 48 hrs by MTT assay ChEMBL. 19501509

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19501509

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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