Detailed information for compound 1070962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 483.58 | Formula: C16H25N3O8S3
  • H donors: 1 H acceptors: 7 LogP: 1.61 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN([C@H]1C[C@H](C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N)C(=O)CCCCCO[N+](=O)[O-]
  • InChi: 1S/C16H25N3O8S3/c1-3-18(14(20)7-5-4-6-8-27-19(21)22)13-9-11(2)29(23,24)16-12(13)10-15(28-16)30(17,25)26/h10-11,13H,3-9H2,1-2H3,(H2,17,25,26)/t11-,13-/m0/s1
  • InChiKey: NURFQAXKIXSLRE-AAEUAGOBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IV Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase IV 312 aa 270 aa 26.7 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0397 0.1988 0.4632
Echinococcus multilocularis SAM and MBT domain containing protein 0.0165 0.0722 0.0712
Echinococcus multilocularis microtubule associated protein 2 0.1586 0.8483 0.8482
Leishmania major cathepsin L-like protease 0.0221 0.1026 1
Trypanosoma cruzi ISWI complex protein 0.0053 0.0109 0.0158
Onchocerca volvulus 0.0058 0.0136 0.1024
Leishmania major cathepsin L-like protease 0.0058 0.0136 0.0451
Brugia malayi Cathepsin L-like precursor 0.0039 0.0032 0.0074
Echinococcus granulosus carbonic anhydrase 0.0101 0.037 0.0423
Loa Loa (eye worm) hypothetical protein 0.015 0.0637 0.1477
Echinococcus multilocularis lamin dm0 0.0093 0.033 0.0319
Loa Loa (eye worm) hypothetical protein 0.0043 0.0057 0.0124
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0021 0.0012
Schistosoma mansoni lipoxygenase 0.0065 0.0173 0.0204
Onchocerca volvulus 0.0272 0.1303 1
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0025
Loa Loa (eye worm) PHD-finger family protein 0.0071 0.021 0.0482
Echinococcus granulosus carbonic anhydrase II 0.0214 0.099 0.1156
Echinococcus granulosus lysine specific demethylase 5A 0.0197 0.0896 0.1045
Loa Loa (eye worm) hypothetical protein 0.006 0.0146 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0613 0.0722
Toxoplasma gondii cathepsin CPL 0.0058 0.0136 0.2837
Echinococcus granulosus histone acetyltransferase MYST2 0.0188 0.0847 0.0987
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0988 0.5216 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0188 0.0847 0.1973
Leishmania major carbonic anhydrase-like protein 0.0214 0.099 0.9612
Trypanosoma cruzi major cysteine proteinase, putative 0.0174 0.0768 0.7229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0413 0.2078 0.4837
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0499 0.0489
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0021 0.0041
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0032 0.0074
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0136 0.0303
Echinococcus multilocularis carbonic anhydrase 0.0101 0.037 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni lamin 0.0093 0.033 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0011 0.0025
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0328 0.1612 0.293
Schistosoma mansoni hypothetical protein 0.0167 0.0732 0.0863
Loa Loa (eye worm) hypothetical protein 0.0101 0.0371 0.0858
Echinococcus multilocularis jumonji domain containing protein 0.0141 0.0587 0.0577
Schistosoma mansoni cpg binding protein 0.0034 0.0003 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.0093 0.033 0.0768
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Loa Loa (eye worm) TAR-binding protein 0.0145 0.0613 0.1421
Brugia malayi hypothetical protein 0.0125 0.05 0.1165
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0188 0.0847 0.0837
Loa Loa (eye worm) hypothetical protein 0.0045 0.0066 0.0146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0011 0.0013
Toxoplasma gondii isocitrate dehydrogenase 0.0055 0.0119 0.2465
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Plasmodium vivax vivapain-2 0.0058 0.0136 0.0241
Loa Loa (eye worm) hypothetical protein 0.0058 0.0136 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni hypothetical protein 0.0587 0.3024 0.3565
Onchocerca volvulus 0.0097 0.0348 0.2655
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0136 0.0303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0055 0.0119 0.0108
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.099 0.9612
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0371 0.0692
Loa Loa (eye worm) isocitrate dehydrogenase 0.0055 0.0119 0.0269
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0136 0.0161
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0066
Echinococcus granulosus cathepsin l1 0.0058 0.0136 0.0148
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0227 0.1418
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0055 0.0119 0.1155
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0165 0.0722 0.0851
Trypanosoma cruzi transcription factor btf3, putative 0.0121 0.0481 0.4149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0047 0.0101
Schistosoma mansoni sex comb on midleg homolog 0.0165 0.0722 0.0851
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0397 0.1988 0.1979
Brugia malayi CXXC zinc finger family protein 0.0034 0.0003 0.0008
Brugia malayi Muscleblind-like protein 0.0342 0.169 0.3937
Leishmania major hypothetical protein, conserved 0.0053 0.0109 0.0158
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0065 0.0173 0.0162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0055 0.0119 0.0108
Brugia malayi mbt repeat family protein 0.0165 0.0722 0.1682
Schistosoma mansoni transcription factor btf3 0.0121 0.0481 0.0567
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.037 0.0861
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0136 0.031
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.099 0.2307
Brugia malayi jmjC domain containing protein 0.0197 0.0896 0.2088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0011 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni hypothetical protein 0.0071 0.021 0.0248
Brugia malayi Isocitrate dehydrogenase 0.0055 0.0119 0.0276
Echinococcus granulosus survival motor neuron protein 1 0.0819 0.4292 0.5053
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0094 0.0212
Echinococcus multilocularis histone acetyltransferase MYST2 0.0188 0.0847 0.0837
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0348 0.0398
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.099 0.1167
Onchocerca volvulus 0.0035 0.0011 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0136 0.0303
Trypanosoma brucei ISWI complex protein 0.0053 0.0109 0.1063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Entamoeba histolytica hypothetical protein 0.0125 0.05 0.1355
Schistosoma mansoni hypothetical protein 0.0587 0.3024 0.3565
Brugia malayi PHD-finger family protein 0.0042 0.0047 0.0109
Trypanosoma cruzi cruzipain precursor, putative 0.0221 0.1026 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0055 0.0119 0.026
Schistosoma mansoni carbonic anhydrase 0.0101 0.037 0.0436
Echinococcus granulosus SAM and MBT domain containing protein 0.0165 0.0722 0.0839
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0613 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0011 0.0025
Brugia malayi hypothetical protein 0.0819 0.4292 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0499 0.0576
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0227 0.1418
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.005 0.0094 0.016
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0055 0.0119 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0011 0.0018
Echinococcus granulosus PHD finger protein rhinoceros 0.0101 0.0371 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0011 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0011 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0146 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0146 0.0172
Brugia malayi nuclear receptor NHR-88 0.0035 0.0011 0.0025
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0227 0.0563
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.037 0.0436
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.037 0.0861
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0011 0.0013
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0055 0.0119 0.0127
Loa Loa (eye worm) ICD-1 protein 0.0121 0.0481 0.1114
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0011 0.0013
Onchocerca volvulus Alhambra homolog 0.0101 0.0371 0.283
Loa Loa (eye worm) hypothetical protein 0.0101 0.037 0.0854
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Echinococcus granulosus intermediate filament protein 0.0093 0.033 0.0376
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0136 0.0126
Brugia malayi jmjC domain containing protein 0.005 0.0094 0.022
Brugia malayi nuclear hormone receptor 0.0035 0.0011 0.0025
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.037 0.0436
Schistosoma mansoni bromodomain containing protein 0.0221 0.1027 0.1211
Brugia malayi Cathepsin L-like precursor 0.0058 0.0136 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0011 0.0025
Brugia malayi Bromodomain containing protein 0.0133 0.0544 0.1268
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.005 0.0094 0.092
Echinococcus granulosus jumonji domain containing protein 0.0141 0.0587 0.068
Brugia malayi MH2 domain containing protein 0.0413 0.2078 0.4841
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0025
Brugia malayi ecdysteroid receptor 0.0035 0.0011 0.0025
Loa Loa (eye worm) ctsf protein 0.0058 0.0136 0.031
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0011 0.0025
Echinococcus granulosus JmjC domain containing protein 4 0.005 0.0094 0.0099
Schistosoma mansoni lamin 0.0093 0.033 0.0389
Schistosoma mansoni cpg binding protein 0.0042 0.005 0.0059
Schistosoma mansoni hypothetical protein 0.0053 0.0109 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0613 0.0722
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0165 0.0722 0.553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0021 0.0012
Echinococcus granulosus cathepsin l1 0.0039 0.0032 0.0025
Echinococcus multilocularis cysteine protease 0.0058 0.0136 0.0126
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0254 0.0593
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.0455 0.1061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0011 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0011 0.0025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0058 0.0136 0.0241
Trypanosoma cruzi ISWI complex protein 0.0053 0.0109 0.0158
Leishmania major cysteine peptidase A (CPA) 0.0058 0.0136 0.0451
Giardia lamblia Fructose-bisphosphate aldolase 0.0672 0.3489 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Entamoeba histolytica hypothetical protein 0.0125 0.05 0.1355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.005 0.0094 0.0111
Echinococcus multilocularis transcription factor btf3 0.0121 0.0481 0.0471
Onchocerca volvulus 0.0093 0.033 0.2512
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0481 0.1299
Brugia malayi RNA recognition motif domain containing protein 0.0145 0.0613 0.1428
Echinococcus granulosus tar DNA binding protein 0.0145 0.0613 0.071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0011 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0613 0.0722
Echinococcus granulosus carbonic anhydrase 0.0101 0.037 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0146 0.0136
Echinococcus multilocularis cpg binding protein 0.0042 0.005 0.0039
Echinococcus multilocularis carbonic anhydrase 0.0101 0.037 0.0359
Schistosoma mansoni methyl-cpg binding protein mbd 0.0059 0.0142 0.0168
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0988 0.5216 1
Schistosoma mansoni microtubule-associated protein tau 0.1586 0.8483 1
Onchocerca volvulus 0.0058 0.0136 0.1024
Leishmania major basic transcription factor 3a, putative 0.0121 0.0481 0.4149
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0059 0.0142 0.0132
Echinococcus granulosus geminin 0.0587 0.3024 0.3557
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0021 0.001
Echinococcus multilocularis survival motor neuron protein 1 0.0819 0.4292 0.4286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0227 0.1418
Echinococcus granulosus cpg binding protein 0.0042 0.005 0.0046
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0058 0.0136 0.031
Schistosoma mansoni phd/f-box containing protein 0.005 0.0094 0.0111
Echinococcus multilocularis fetal alzheimer antigen, falz 0.008 0.0257 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0011 0.0025
Echinococcus multilocularis muscleblind protein 0.0342 0.169 0.1681
Schistosoma mansoni hypothetical protein 0.0101 0.0371 0.0438
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0348 0.0812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.059 0.1368
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0055 0.0119 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0101 0.0371 0.0361
Echinococcus multilocularis phd:f box containing protein 0.005 0.0094 0.0084
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Brugia malayi steroid hormone receptor 0.0035 0.0011 0.0025
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0025
Onchocerca volvulus 0.0165 0.0722 0.553
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.037 0.0861
Entamoeba histolytica hypothetical protein 0.0121 0.0481 0.1299
Schistosoma mansoni hypothetical protein 0.0125 0.05 0.059
Echinococcus granulosus transcription factor btf3 0.0121 0.0481 0.0555
Echinococcus multilocularis muscleblind protein 1 0.0342 0.169 0.1681
Loa Loa (eye worm) hypothetical protein 0.0165 0.0722 0.1675
Schistosoma mansoni survival motor neuron protein 0.0167 0.0732 0.0863
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Echinococcus granulosus muscleblind protein 0.0342 0.169 0.1982
Loa Loa (eye worm) cysteine protease 0.0058 0.0136 0.031
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0032 0.0037
Onchocerca volvulus 0.0058 0.0136 0.1024
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0988 0.5216 1
Brugia malayi beta-NAC-like protein 0.0121 0.0481 0.1121
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0136 0.0318
Brugia malayi jmjC domain containing protein 0.005 0.0094 0.022
Schistosoma mansoni protein phosphatase 2C 0.005 0.0094 0.0111
Loa Loa (eye worm) PHD-finger family protein 0.0101 0.0371 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0011 0.0025
Schistosoma mansoni phosphatidylserine receptor 0.005 0.0094 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0057 0.0124
Loa Loa (eye worm) hypothetical protein 0.0819 0.4292 1
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0011 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0101 0.037 0.0854
Brugia malayi RNA binding protein 0.0145 0.0613 0.1428
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0065 0.0173 0.0191
Echinococcus granulosus dnaJ subfamily B 0.0479 0.2435 0.2861
Brugia malayi Bromodomain containing protein 0.0109 0.0416 0.0969
Onchocerca volvulus 0.0058 0.0136 0.1024
Toxoplasma gondii hypothetical protein 0.0101 0.037 0.7683
Echinococcus multilocularis geminin 0.0587 0.3024 0.3017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0011 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0221 0.1026 1
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0011 0.0013
Brugia malayi intermediate filament protein 0.0093 0.033 0.0768
Brugia malayi TAR-binding protein 0.0145 0.0613 0.1428
Loa Loa (eye worm) jmjC domain-containing protein 0.0208 0.0958 0.2227
Echinococcus granulosus lamin dm0 0.0093 0.033 0.0376
Entamoeba histolytica hypothetical protein 0.0125 0.05 0.1355
Toxoplasma gondii isocitrate dehydrogenase 0.0055 0.0119 0.2465
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0066
Brugia malayi Cathepsin L-like precursor 0.0058 0.0136 0.0318
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.008 0.0257 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0011 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0011 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0146 0.0172
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0136 0.1024
Plasmodium vivax vivapain-2 0.0058 0.0136 0.0241
Plasmodium falciparum basic transcription factor 3b, putative 0.0121 0.0481 0.0903
Entamoeba histolytica cysteine protease, putative 0.0058 0.0136 0.0303
Echinococcus multilocularis carbonic anhydrase 0.0101 0.037 0.0359
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0011 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Loa Loa (eye worm) RNA binding protein 0.0145 0.0613 0.1421
Echinococcus multilocularis GPCR, family 2 0.0037 0.0021 0.001
Brugia malayi PHD-finger family protein 0.0101 0.0371 0.0865
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0227 0.0267
Entamoeba histolytica hypothetical protein 0.0125 0.05 0.1355
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.099 0.2301
Echinococcus multilocularis zinc finger protein 0.007 0.02 0.019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0655 0.3399 0.3999
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0011 0.0013
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0136 0.0126
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0136 0.0126
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0202 0.0922 0.8877
Loa Loa (eye worm) hypothetical protein 0.0245 0.1157 0.2691
Loa Loa (eye worm) hypothetical protein 0.0037 0.0021 0.0041
Schistosoma mansoni zinc finger protein 0.007 0.02 0.0236
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0188 0.0847 0.1967
Entamoeba histolytica transcription factor BTF3, putative 0.0121 0.0481 0.1299
Loa Loa (eye worm) hypothetical protein 0.0101 0.037 0.0854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0011 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0413 0.2078 0.4837
Echinococcus multilocularis tar DNA binding protein 0.0145 0.0613 0.0603
Plasmodium falciparum cysteine proteinase falcipain 3 0.0058 0.0136 0.0241
Plasmodium vivax basic transcription factor 3b, putative 0.0121 0.0481 0.0903
Echinococcus multilocularis peregrin 0.0109 0.0416 0.0405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0125 0.05 0.049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni hypothetical protein 0.0479 0.2435 0.287
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0094 0.0212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0046 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0011 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0094 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0011 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0481 0.1299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0021 0.001
Plasmodium vivax JmjC domain containing protein 0.005 0.0094 0.016
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0136 0.0451
Loa Loa (eye worm) hypothetical protein 0.005 0.0094 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0125 0.05 0.0577
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.1303 0.303
Toxoplasma gondii histone lysine demethylase JMJD6a 0.005 0.0094 0.1962
Loa Loa (eye worm) hypothetical protein 0.0092 0.032 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0227 0.0528
Brugia malayi Pax transcription factor protein 2 0.0272 0.1303 0.3035
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0348 0.0411
Leishmania major cathepsin L-like protease 0.0221 0.1026 1
Brugia malayi mbt repeat family protein 0.0165 0.0722 0.1682
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.099 0.2307
Schistosoma mansoni hypothetical protein 0.0101 0.037 0.0436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.0455 0.1054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Schistosoma mansoni methyl-cpg binding protein mbd 0.0059 0.0142 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0059 0.0141 0.0154
Plasmodium falciparum carbonic anhydrase 0.0101 0.037 0.0688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0101 0.0371 0.0438
Leishmania major cathepsin L-like protease 0.0058 0.0136 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0011 0.0025
Brugia malayi Cathepsin L-like precursor 0.0058 0.0136 0.0318
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0055 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0342 0.169 0.3933
Echinococcus granulosus cathepsin L cysteine proteinase 0.0058 0.0136 0.0148
Brugia malayi F/Y-rich N-terminus family protein 0.005 0.0092 0.0215
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0066
Toxoplasma gondii PHD-finger domain-containing protein 0.0101 0.0371 0.7716
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0059 0.0141 0.013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0672 0.3489 1
Echinococcus granulosus lamin 0.0093 0.033 0.0376
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0145 0.0613 0.1421
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0021 0.0049
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0227 0.2207
Brugia malayi jmjC domain containing protein 0.005 0.0094 0.022
Loa Loa (eye worm) hypothetical protein 0.0093 0.033 0.0761
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0055 0.0119 0.0206
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0011 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0011 0.0018
Onchocerca volvulus 0.0093 0.033 0.2512
Loa Loa (eye worm) hypothetical protein 0.005 0.0094 0.0212
Loa Loa (eye worm) mbt repeat family protein 0.0165 0.0722 0.1675
Leishmania major cathepsin L-like protease 0.0221 0.1026 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.099 0.2301
Schistosoma mansoni cpg binding protein 0.0042 0.005 0.0059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0018
Echinococcus granulosus microtubule associated protein 2 0.1586 0.8483 1
Onchocerca volvulus 0.0058 0.0136 0.1024
Echinococcus multilocularis dnaJ subfamily B 0.0479 0.2435 0.2426
Schistosoma mansoni intermediate filament proteins 0.0093 0.033 0.0389
Echinococcus multilocularis jumonji domain containing 1A 0.005 0.0094 0.0084
Plasmodium falciparum phd finger protein, putative 0.0101 0.0371 0.0692
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0055 0.0119 0.026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0197 0.0896 0.1056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0045 0.0066 0.0055
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.037 0.0861
Loa Loa (eye worm) intermediate filament protein 0.0093 0.033 0.0761
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0188 0.0847 0.0987
Echinococcus granulosus lysine specific demethylase 6a 0.005 0.0094 0.0099
Brugia malayi Cathepsin L-like precursor 0.0058 0.0136 0.0318
Loa Loa (eye worm) hypothetical protein 0.0342 0.169 0.3933
Schistosoma mansoni jumonji/arid domain-containing protein 0.0197 0.0896 0.1056
Echinococcus granulosus methyl CpG binding domain protein 2 0.0059 0.0142 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0116 0.0455 0.1054
Echinococcus granulosus phd:f box containing protein 0.005 0.0094 0.0099
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0055 0.0119 0.014
Brugia malayi Cathepsin L-like precursor 0.0039 0.0032 0.0074
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.099 0.9648
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0011 0.0025
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0988 0.5216 1
Echinococcus multilocularis cysteine protease 0.0058 0.0136 0.0126
Echinococcus multilocularis isocitrate dehydrogenase 0.0055 0.0119 0.0108
Schistosoma mansoni coup transcription factor 0.0035 0.0011 0.0013
Trypanosoma cruzi transcription factor btf3, putative 0.0121 0.0481 0.4149
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.037 0.0436
Onchocerca volvulus 0.0167 0.0732 0.5607
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0045 0.0066 0.0065
Brugia malayi PHD-finger family protein 0.0088 0.0301 0.0702
Loa Loa (eye worm) jmjC domain-containing protein 0.0197 0.0896 0.2082
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0655 0.3399 0.3392
Toxoplasma gondii PHD-finger domain-containing protein 0.0101 0.0371 0.7716
Toxoplasma gondii NAC domain-containing protein 0.0121 0.0481 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0209 0.0247
Onchocerca volvulus 0.0058 0.0136 0.1024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0209 0.0959 0.0949
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0055 0.0119 0.0108
Brugia malayi Cathepsin L-like precursor 0.0058 0.0136 0.0318
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.037 0.0861
Echinococcus multilocularis musashi 0.0093 0.033 0.0319
Leishmania major cathepsin L-like protease 0.0058 0.0136 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0397 0.1988 0.2334
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0227 0.052
Onchocerca volvulus 0.0058 0.0136 0.1024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.0455 0.1061
Echinococcus granulosus peregrin 0.0109 0.0416 0.0478
Loa Loa (eye worm) bromodomain containing protein 0.0061 0.0154 0.0351
Brugia malayi cytoplasmic intermediate filament protein 0.005 0.0093 0.0217
Loa Loa (eye worm) fibroinase 0.0058 0.0136 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.0221 0.1026 1
Schistosoma mansoni transcription factor LCR-F1 0.0125 0.05 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0227 0.0254
Loa Loa (eye worm) hypothetical protein 0.0097 0.0348 0.0804
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni hypothetical protein 0.1009 0.5328 0.628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0136 0.1024
Leishmania major cathepsin L-like protease 0.0058 0.0136 0.0451
Echinococcus multilocularis lysine specific demethylase 5A 0.0189 0.085 0.084
Echinococcus multilocularis lamin 0.0093 0.033 0.0319
Onchocerca volvulus 0.0039 0.0032 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0145 0.0613 0.0722
Echinococcus granulosus GPCR family 2 0.0037 0.0021 0.0012
Schistosoma mansoni sex comb on midleg homolog 0.0165 0.0722 0.0851
Brugia malayi Cathepsin L-like precursor 0.0058 0.0136 0.0318
Loa Loa (eye worm) hypothetical protein 0.0133 0.0545 0.1264
Echinococcus granulosus fetal alzheimer antigen falz 0.008 0.0257 0.029
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.037 0.0854
Echinococcus granulosus cathepsin l cysteine peptidase 0.0058 0.0136 0.0148
Schistosoma mansoni zinc finger protein 0.0053 0.0109 0.0129
Treponema pallidum hypothetical protein 0.0988 0.5216 1
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0481 0.1299
Loa Loa (eye worm) MBCTL1 0.0188 0.0847 0.1967
Brugia malayi Bromodomain containing protein 0.0262 0.1249 0.2909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0191 0.0862 0.2001
Schistosoma mansoni jumonji domain containing protein 0.005 0.0094 0.0111
Schistosoma mansoni jumonji domain containing protein 0.0329 0.1617 0.1906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0672 0.3489 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0348 0.0338
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0167 0.0732 0.1705
Loa Loa (eye worm) hypothetical protein 0.008 0.0254 0.0585
Echinococcus granulosus carbonic anhydrase 0.0101 0.037 0.0423
Echinococcus multilocularis polycomb protein SCMH1 0.0165 0.0722 0.0712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0136 0.0303
Echinococcus granulosus polycomb protein SCMH1 0.0165 0.0722 0.0839
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0136 0.0126
Schistosoma mansoni hypothetical protein 0.0037 0.0021 0.0025
Onchocerca volvulus Cathepsin F homolog 0.0058 0.0136 0.1024
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.099 0.9612
Schistosoma mansoni myelin transcription factor 1 myt1 0.0188 0.0847 0.0998
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0209 0.0959 0.1119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0136 0.0303
Brugia malayi cathepsin L-like precursor 0.0039 0.0032 0.0074
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0988 0.5216 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0011 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0212 0.4415
Trypanosoma brucei transcription factor BTF3, putative 0.0121 0.0481 0.4687
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0055 0.0119 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0058 0.0136 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0221 0.1026 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0093 0.033 0.0761
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0136 0.0161
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.099 0.098
Brugia malayi isocitrate dehydrogenase 0.0055 0.0119 0.0276
Schistosoma mansoni hypothetical protein 0.008 0.0254 0.03
Echinococcus multilocularis lysine specific demethylase 6a 0.005 0.0094 0.0084
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0672 0.3489 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.099 0.1167
Echinococcus granulosus jumonji domain containing 1A 0.005 0.0094 0.0099
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.005 0.0094 0.1962
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0011 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0055 0.0119 0.1155
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0227 0.0216
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.005 0.0093 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0136 0.0303
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0011 0.0058
Leishmania major cathepsin L-like protease 0.0058 0.0136 0.0451
Brugia malayi jmjC domain containing protein 0.005 0.0094 0.022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0011 0.0025
Echinococcus multilocularis JmjC domain containing protein 4 0.005 0.0094 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1026 1
Echinococcus granulosus zinc finger protein 0.007 0.02 0.0224

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 14 nM Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assay ChEMBL. 19854054
Ki (binding) = 2950 nM Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assay ChEMBL. 19854054
Ki (binding) = 4360 nM Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assay ChEMBL. 19854054

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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