TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 575.124 | Formula: C30H31ClN6O2S
H donors: 1 H acceptors: 3 LogP: 6.31 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2ncnc(c2cc1OCCCN1CCN(CC1)C)Nc1ccc(cc1)c1nc2c(s1)ccc(c2)Cl
InChi: 1S/C30H31ClN6O2S/c1-36-11-13-37(14-12-36)10-3-15-39-27-17-23-24(18-26(27)38-2)32-19-33-29(23)34-22-7-4-20(5-8-22)30-35-25-16-21(31)6-9-28(25)40-30/h4-9,16-19H,3,10-15H2,1-2H3,(H,32,33,34)
InChiKey: WCRYRBRNFCXTTR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	platelet-derived growth factor receptor, beta polypeptide	Starlite/ChEMBL	References
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References
Homo sapiens	erb-b2 receptor tyrosine kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0019	0.0044
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0058	0.0136
Echinococcus granulosus	titin	0.0015	0.003	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0054	0.0437	0.0557
Schistosoma mansoni	importin beta-1	0.0034	0.0235	0.03
Brugia malayi	Muscleblind-like protein	0.0178	0.174	0.411
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0022	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0178	0.174	0.411
Brugia malayi	protein unc-22	0.0015	0.003	0.0071
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0198	0.1951	0.2486
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0156	0.0369
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.025	0.0279
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0469	0.0597
Echinococcus multilocularis	epidermal growth factor receptor	0.0365	0.3698	0.3698
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.025	0.1488
Schistosoma mansoni	vesicular amine transporter	0.0022	0.0111	0.0141
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0363	0.0347
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0043	0.01
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0451	0.1066
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0088	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0019	0.0044
Trypanosoma brucei	aurora B kinase	0.0136	0.1303	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.025	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0473	0.1116
Onchocerca volvulus		0.0036	0.025	0.0586
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.025	0.1328
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0292	0.0691
Echinococcus multilocularis	Immunoglobulin subtype	0.0012	0.0000090706	0.0000090706
Schistosoma mansoni	neuroglian	0.0026	0.0143	0.0182
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0136	0.1303	0.1809
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0025	0.014	0.0079
Onchocerca volvulus		0.0034	0.0234	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0428	0.1012
Schistosoma mansoni	hypothetical protein	0.0487	0.4982	0.6347
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.025	0.0279
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.025	0.0171
Entamoeba histolytica	protein kinase, putative	0.0136	0.1303	0.1809
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0054	0.0437	0.0462
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0073	0.0642	0.4557
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0016	0.0046	0.0058
Schistosoma mansoni	septate junction protein	0.0021	0.0098	0.0124
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.003	0.0071
Entamoeba histolytica	protein kinase domain containing protein	0.0136	0.1303	0.1809
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0367	0.3719	0.8782
Echinococcus granulosus	neuroglian	0.0032	0.0209	0.0266
Schistosoma mansoni	cpg binding protein	0.0034	0.0234	0.0298
Entamoeba histolytica	protein kinase , putative	0.0136	0.1303	0.1809
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.025	0.1488
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0034	0.0236	0.03
Echinococcus granulosus	epidermal growth factor receptor	0.0365	0.3698	0.4711
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0019	0.0044
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0269	0.0635
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0057	0.0469	0.0469
Schistosoma mansoni	pyruvate kinase	0.004	0.0292	0.0372
Schistosoma mansoni	hypothetical protein	0.0367	0.3719	0.4738
Onchocerca volvulus		0.0015	0.003	0.003
Schistosoma mansoni	serine/threonine protein kinase	0.0136	0.1303	0.166
Onchocerca volvulus		0.0375	0.3805	0.9577
Echinococcus multilocularis		0.0111	0.1044	0.1044
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Echinococcus granulosus	twitchin	0.0033	0.022	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0269	0.0636
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0124	0.1175	0.1497
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0416	0.4234	1
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0028	0.0167	0.5
Echinococcus multilocularis	lachesin	0.0021	0.0098	0.0098
Mycobacterium tuberculosis	Conserved protein	0.0036	0.025	0.0279
Loa Loa (eye worm)	acetyltransferase	0.0176	0.1715	0.4049
Leishmania major	GTP-binding protein, putative	0.0025	0.014	0.0598
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0167	0.0042
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0249	0.2482	0.5861
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0026	0.0143	0.0182
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0058	0.0058
Trypanosoma brucei	hypothetical protein, conserved	0.0028	0.0167	0.0816
Echinococcus granulosus	roundabout 2	0.0026	0.0143	0.0183
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0021	0.0098	0.0098
Entamoeba histolytica	hypothetical protein	0.0028	0.0167	0.0042
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0054	0.0437	0.2867
Leishmania major	pyruvate kinase	0.004	0.0292	0.1823
Mycobacterium tuberculosis	Conserved protein	0.0036	0.025	0.0279
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0025	0.014	0.0422
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0026	0.0143	0.0338
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.025	0.0279
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0016	0.0046	0.0046
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0058	0.0136
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0014	0.0019	0.0024
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0167	0.0816
Echinococcus multilocularis	Immunoglobulin	0.0022	0.0111	0.0111
Brugia malayi	beta-lactamase family protein	0.0036	0.025	0.0591
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0133	0.0314
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0058	0.0058
Onchocerca volvulus		0.0099	0.0913	0.2264
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0025	0.014	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0758	0.1791
Echinococcus multilocularis	roundabout 2	0.0026	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0054	0.0437	0.2867
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0017	0.0058	0.0073
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0176	0.1715	0.1715
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.003	0.0038
Echinococcus granulosus	contactin	0.0026	0.0143	0.0183
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Schistosoma mansoni	hypothetical protein	0.0025	0.0133	0.0169
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0088	0.0088
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0312	0.3145	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0058	0.0073
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0124	0.1175	0.1175
Onchocerca volvulus	Huntingtin homolog	0.0146	0.1405	0.3507
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0469	0.1107
Brugia malayi	acetyltransferase, GNAT family protein	0.0176	0.1715	0.4049
Schistosoma mansoni	zinc finger protein	0.0018	0.0066	0.0084
Brugia malayi	hypothetical protein	0.0027	0.0156	0.0369
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0098	0.0231
Echinococcus granulosus	hemicentin 1	0.0021	0.0098	0.0125
Loa Loa (eye worm)	bromodomain containing protein	0.0025	0.014	0.0331
Loa Loa (eye worm)	TK/ROR protein kinase	0.0016	0.0043	0.0101
Schistosoma mansoni	roundabout	0.0021	0.0098	0.0124
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0324	0.0413
Schistosoma mansoni	ran	0.0025	0.014	0.0179
Echinococcus multilocularis	hemicentin 1	0.0021	0.0098	0.0098
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0365	0.3698	0.8733
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0054	0.0437	0.2867
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0046	0.0108
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0098	0.0124
Echinococcus multilocularis	zinc finger protein	0.003	0.0185	0.0185
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0324	0.0324
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.0292	0.1823
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0099	0.0913	0.1164
Schistosoma mansoni	titin	0.0021	0.0098	0.0124
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0026	0.0143	0.0143
Brugia malayi	Bromodomain containing protein	0.005	0.0398	0.0939
Echinococcus granulosus	GPCR family 2	0.0017	0.0058	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0156	0.0369
Brugia malayi	MH2 domain containing protein	0.0132	0.1255	0.2963
Loa Loa (eye worm)	hypothetical protein	0.004	0.0292	0.0689
Schistosoma mansoni	cell adhesion molecule	0.0026	0.0143	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0136	0.1303	0.1809
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0058	0.0073
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Echinococcus multilocularis	hemicentin 1	0.0021	0.0098	0.0098
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.025	0.0279
Schistosoma mansoni	nephrin	0.0036	0.0254	0.0323
Mycobacterium leprae	Probable pyruvate kinase PykA	0.004	0.0292	0.0418
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0143	0.0338
Schistosoma mansoni	myosin-binding protein-related	0.0014	0.0019	0.0024
Trypanosoma brucei	pyruvate kinase 1	0.004	0.0292	0.1823
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.025	0.0591
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0019	0.0044
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0021	0.0098	0.02
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0354	0.0837
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0363	0.2258
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0022	0.0111	0.0141
Brugia malayi	Furin-like cysteine rich region family protein	0.0365	0.3698	0.8732
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0088	0.0112
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0016	0.0043	0.0054
Echinococcus granulosus	histone lysine methyltransferase setb	0.0057	0.0469	0.0597
Schistosoma mansoni	tyrosine kinase	0.0028	0.0167	0.0213
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.025	0.0591
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0143	0.0338
Echinococcus multilocularis	pyruvate kinase	0.002	0.0089	0.0089
Brugia malayi	beta-lactamase	0.0036	0.025	0.0591
Loa Loa (eye worm)	pyruvate kinase-PB	0.0028	0.0166	0.0392
Brugia malayi	PHD-finger family protein	0.0036	0.0251	0.0593
Echinococcus granulosus	Immunoglobulin	0.0022	0.0111	0.0141
Loa Loa (eye worm)	beta-lactamase	0.0036	0.025	0.0591
Mycobacterium ulcerans	pyruvate kinase	0.004	0.0292	0.0418
Echinococcus multilocularis	roundabout 2	0.0048	0.0379	0.0379
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0028	0.0167	0.0644
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0292	0.0689
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0046	0.0107
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0143	0.0143
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0256	0.0256
Trichomonas vaginalis	AGC family protein kinase	0.0136	0.1303	0.1809
Leishmania major	pyruvate kinase	0.004	0.0292	0.1823
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0058	0.0073
Loa Loa (eye worm)	projectin	0.0014	0.0019	0.0044
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0021	0.0098	0.0231
Schistosoma mansoni	tyrosine kinase	0.012	0.113	0.1439
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0363	0.0423
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0058	0.0058
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.025	0.0319
Schistosoma mansoni	hypothetical protein	0.0027	0.0159	0.0202
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0292	0.0691
Mycobacterium ulcerans	beta-lactamase	0.0036	0.025	0.0279
Brugia malayi	Pyruvate kinase, muscle isozyme	0.004	0.0292	0.0689
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0019	0.0044
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.025	0.0279
Echinococcus multilocularis	protein quaking	0.0027	0.0159	0.0159
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0111	0.1041	0.7881
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0099	0.0913	0.0913
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0088	0.0112
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0027	0.0156	0.0369
Onchocerca volvulus		0.0283	0.2841	0.7139
Echinococcus granulosus	aurora kinase A	0.0136	0.1303	0.166
Echinococcus granulosus	insulin receptor	0.012	0.113	0.1439
Leishmania major	phosphopantetheinyl transferase-like protein	0.0028	0.0167	0.0816
Brugia malayi	Pre-SET motif family protein	0.0036	0.0256	0.0604
Trypanosoma brucei	calpain, putative	0.0111	0.1041	0.7881
Brugia malayi	serine/threonine-protein kinase 6	0.0136	0.1303	0.3077
Echinococcus granulosus	snurportin 1	0.0367	0.3719	0.4738
Echinococcus granulosus	L aminoadipate semialdehyde	0.0099	0.0913	0.1164
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0019	0.0044
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0235	0.1367
Echinococcus granulosus	muscleblind protein	0.0178	0.174	0.2217
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Echinococcus multilocularis	roundabout 2	0.0026	0.0143	0.0143
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0312	0.3145	1
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0235	0.03
Echinococcus granulosus	tyrosine protein kinase otk	0.0021	0.0098	0.0125
Trypanosoma brucei	calpain-like protein, putative	0.0111	0.1041	0.7881
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.014	0.0598
Trichomonas vaginalis	AGC family protein kinase	0.0136	0.1303	0.1809
Giardia lamblia	Aurora kinase	0.0136	0.1303	0.1873
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Schistosoma mansoni	titin	0.0014	0.0019	0.0024
Brugia malayi	hypothetical protein	0.0027	0.0159	0.0375
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.025	0.025
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0028	0.0167	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0178	0.174	0.411
Mycobacterium tuberculosis	Conserved protein	0.0036	0.025	0.0279
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0136	0.1303	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0451	0.1066
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0292	0.0689
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0058	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0019	0.0044
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0167	0.0042
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0136	0.1303	0.1809
Echinococcus granulosus	epidermal growth factor receptor	0.0198	0.1951	0.2486
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0136	0.1303	0.1809
Brugia malayi	beta-lactamase family protein	0.0036	0.025	0.0591
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0029	0.0177	0.0177
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0167	0.0816
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0111	0.1041	0.7881
Schistosoma mansoni	pyruvate kinase	0.004	0.0292	0.0372
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0025	0.014	0.0422
Echinococcus granulosus	hypothetical protein	0.0027	0.0159	0.0202
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0098	0.0231
Brugia malayi	Peroxidasin	0.0021	0.0098	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Plasmodium vivax	pyruvate kinase, putative	0.004	0.0292	0.167
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0136	0.1303	0.166
Echinococcus granulosus	peroxidasin	0.0021	0.0098	0.0125
Trypanosoma cruzi	aurora B kinase, putative	0.0136	0.1303	1
Echinococcus granulosus	dnaJ subfamily B	0.0487	0.4982	0.6348
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0639	0.6569	1
Echinococcus multilocularis	aurora kinase A	0.0136	0.1303	0.1303
Schistosoma mansoni	cell adhesion molecule	0.0039	0.0281	0.0358
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0043	0.0101
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.1255	0.2963
Loa Loa (eye worm)	CAMK protein kinase	0.0015	0.003	0.0071
Echinococcus granulosus	pyruvate kinase	0.004	0.0292	0.0372
Echinococcus granulosus	pyruvate kinase	0.002	0.0089	0.0114
Echinococcus multilocularis	neuroglian	0.0026	0.0143	0.0143
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0416	0.4234	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0111	0.1041	0.7881
Trichomonas vaginalis	set domain proteins, putative	0.0283	0.2841	0.4201
Echinococcus multilocularis	titin	0.0015	0.003	0.003
Schistosoma mansoni	bromodomain containing protein	0.0082	0.073	0.093
Echinococcus multilocularis	Immunoglobulin	0.0022	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0262
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0098	0.0231
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.025	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0166	0.0392
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0256	0.0326
Brugia malayi	Pre-SET motif family protein	0.0249	0.2482	0.5861
Chlamydia trachomatis	pyruvate kinase	0.004	0.0292	1
Schistosoma mansoni	zinc finger protein	0.003	0.0185	0.0235
Brugia malayi	Fibronectin type III domain containing protein	0.0027	0.0156	0.0369
Giardia lamblia	Pyruvate kinase	0.004	0.0292	0.0313
Trypanosoma brucei	hypothetical protein	0.0111	0.1041	0.7881
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.0292	0.1823
Echinococcus multilocularis	peroxidasin	0.0021	0.0098	0.0098
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0012	0.0000090706	0.0000090706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0019	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0036	0.025	0.0591
Schistosoma mansoni	hypothetical protein	0.0014	0.0019	0.0024
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0111	0.1041	0.7881
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.004	0.0292	0.0418
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.014	0.0598
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0019	0.0044
Echinococcus granulosus	pyruvate kinase	0.004	0.0292	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0333	0.0787
Trichomonas vaginalis	esterase, putative	0.0036	0.025	0.0171
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0019	0.0024
Onchocerca volvulus	Tyrosine kinase homolog	0.0391	0.3972	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.004	0.0292	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1405	0.3318
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0025	0.014	0.0422
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.025	0.0279
Schistosoma mansoni	hypothetical protein	0.0017	0.0058	0.0073
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.0292	0.0236
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.025	0.0171
Mycobacterium ulcerans	lipase LipD	0.0036	0.025	0.0279
Onchocerca volvulus		0.0036	0.025	0.0586
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.025	0.0171
Schistosoma mansoni	nephrin	0.0026	0.0143	0.0182
Brugia malayi	serine/threonine protein kinase 6	0.0136	0.1303	0.3077
Entamoeba histolytica	hypothetical protein	0.0028	0.0167	0.0042
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0054	0.0437	0.0462
Mycobacterium ulcerans	hypothetical protein	0.0036	0.025	0.0279
Trichomonas vaginalis	AGC family protein kinase	0.0136	0.1303	0.1809
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0469	0.0597
Echinococcus multilocularis	transfer RNA-Phe	0.0014	0.0019	0.0019
Toxoplasma gondii	aurora kinase	0.0136	0.1303	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.2271	0.7066
Plasmodium falciparum	pyruvate kinase	0.004	0.0292	0.167
Echinococcus multilocularis	neuroglian	0.0032	0.0209	0.0209
Loa Loa (eye worm)	TK/INSR protein kinase	0.012	0.113	0.2667
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0234	0.0552
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.025	0.0279
Onchocerca volvulus	Pyruvate kinase homolog	0.004	0.0292	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0159	0.0375
Echinococcus multilocularis	Immunoglobulin	0.0012	0.0000090706	0.0000090706
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0143	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0036	0.025	0.0591
Echinococcus granulosus	titin	0.0015	0.003	0.0038
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0099	0.0913	0.2157
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0028	0.0167	0.0644
Schistosoma mansoni	tyrosine kinase	0.0365	0.3698	0.4711
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0077	0.0686	0.0873
Brugia malayi	Temporarily assigned gene name protein 44	0.0027	0.0159	0.0375
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0016	0.0043	0.0043
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0234	0.0552
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0235	0.1367
Schistosoma mansoni	tyrosine kinase	0.0198	0.1951	0.2486
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0143	0.0338
Toxoplasma gondii	ABC1 family protein	0.0036	0.025	0.1328
Loa Loa (eye worm)	AUR protein kinase	0.0136	0.1303	0.3077
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.025	0.0171
Schistosoma mansoni	tyrosine kinase	0.0191	0.1882	0.2397
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.014	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0136	0.1303	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0014	0.0022	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Loa Loa (eye worm)	pyruvate kinase	0.004	0.0292	0.0689
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Trypanosoma brucei	pyruvate kinase 1, putative	0.004	0.0292	0.1823
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0913	0.2157
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0021	0.0098	0.0231
Echinococcus granulosus	lachesin	0.0021	0.0098	0.0125
Schistosoma mansoni	tyrosine kinase	0.0191	0.1882	0.2397
Echinococcus granulosus	roundabout 2	0.0048	0.0379	0.0483
Plasmodium vivax	SET domain protein, putative	0.0036	0.0256	0.1374
Schistosoma mansoni	microtubule-associated protein tau	0.0761	0.7849	1
Schistosoma mansoni	cpg binding protein	0.0038	0.0278	0.0354
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0027	0.0155	0.0366
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.025	0.0319
Echinococcus multilocularis	tyrosine protein kinase otk	0.0021	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0451	0.1066
Echinococcus multilocularis	netrin receptor unc 5	0.0012	0.0000090706	0.0000090706
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0262
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0077	0.0686	0.0686
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.025	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0036	0.025	0.0591
Echinococcus multilocularis	insulin receptor	0.012	0.113	0.113
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0012	0.0001	0.0003
Echinococcus multilocularis	snurportin 1	0.0367	0.3719	0.3719
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.025	0.1488
Brugia malayi	RNA, U transporter 1	0.0098	0.0899	0.2123
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Brugia malayi	Importin beta-1 subunit	0.0034	0.0235	0.0556
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.025	0.0319
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.025	0.0171
Brugia malayi	hypothetical protein	0.0146	0.1405	0.3318
Echinococcus multilocularis	Immunoglobulin	0.0012	0.0000090706	0.0000090706
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.0012	0.0000090706	0.0000090706
Loa Loa (eye worm)	tumor suppressor	0.032	0.3225	0.7616
Echinococcus granulosus	pyruvate kinase	0.002	0.0089	0.0114
Treponema pallidum	fructose-bisphosphate aldolase	0.0639	0.6569	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0026	0.0143	0.0143
Schistosoma mansoni	tyrosine kinase	0.0198	0.1951	0.2486
Echinococcus granulosus	neuroglian	0.0026	0.0143	0.0183
Schistosoma mansoni	hypothetical protein	0.0018	0.0066	0.0084
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0136	0.1303	0.1303
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0451	0.1066
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Leishmania major	protein kinase, putative	0.0136	0.1303	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.1041	0.7881
Schistosoma mansoni	cell adhesion molecule	0.0014	0.0019	0.0024
Onchocerca volvulus	Huntingtin homolog	0.0146	0.1405	0.3507
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0098	0.0231
Echinococcus granulosus	roundabout 2	0.0026	0.0143	0.0183
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.003	0.0071
Schistosoma mansoni	hemicentin	0.0014	0.0019	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Echinococcus granulosus	nephrin	0.0014	0.0019	0.0024
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0098	0.0231
Schistosoma mansoni	septate junction protein	0.0021	0.0098	0.0124
Schistosoma mansoni	cpg binding protein	0.0038	0.0278	0.0354
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.1255	0.2963
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0111	0.0262
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.014	0.0331
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0256	0.1374
Echinococcus granulosus	cpg binding protein	0.0038	0.0278	0.0354
Schistosoma mansoni	hypothetical protein	0.0027	0.0159	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0098	0.0231
Mycobacterium leprae	Probable lipase LipE	0.0036	0.025	0.0279
Loa Loa (eye worm)	AUR protein kinase	0.0136	0.1303	0.3077
Echinococcus multilocularis	pyruvate kinase	0.0031	0.0204	0.0204
Schistosoma mansoni	protein kinase	0.0136	0.1303	0.166
Schistosoma mansoni	hypothetical protein	0.0017	0.0058	0.0073
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0019	0.0044
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0019	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0235	0.0556
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.014	0.0331
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0026	0.0143	0.0143
Brugia malayi	tumor suppressor.	0.032	0.3225	0.7616
Echinococcus multilocularis	cpg binding protein	0.0038	0.0278	0.0278
Echinococcus granulosus	microtubule associated protein 2	0.0761	0.7849	1
Plasmodium falciparum	importin beta, putative	0.0034	0.0235	0.1205
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0235	0.1205
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0168	0.1634	0.2082
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0021	0.0098	0.0124
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0234	0.0299
Schistosoma mansoni	tyrosine kinase	0.0191	0.1882	0.2397
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0312	0.3145	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0235	0.1205
Brugia malayi	Prion-like-	0.0021	0.0098	0.0231
Onchocerca volvulus		0.0036	0.025	0.0586
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0098	0.0231
Entamoeba histolytica	pyruvate kinase, putative	0.0028	0.0166	0.004
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0639	0.6569	1
Schistosoma mansoni	titin	0.0015	0.003	0.0038
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0012	0.0000090706	0.0000090706
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0028	0.0167	0.0644
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.065	0.0828
Brugia malayi	Protein kinase domain containing protein	0.012	0.113	0.2667
Echinococcus multilocularis	epidermal growth factor receptor	0.0198	0.1951	0.1951
Leishmania major	hypothetical protein, conserved	0.0036	0.025	0.1488
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0111	0.1041	0.7881
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0111	0.1041	0.7881
Echinococcus multilocularis	dnaJ subfamily B	0.0487	0.4982	0.4982
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0256	0.0326
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0022	0.0111	0.0141
Echinococcus multilocularis	pyruvate kinase	0.004	0.0292	0.0292
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0176	0.1715	0.2184
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0012	0.0000090706	0.0000090706
Echinococcus multilocularis	muscleblind protein 1	0.0178	0.174	0.174
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0333	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0156	0.0369
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0029	0.0177	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1405	0.3318
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0143	0.0183
Schistosoma mansoni	ran	0.0025	0.014	0.0179
Brugia malayi	Bromodomain containing protein	0.0096	0.0877	0.207
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0111	0.1041	0.7881
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0058	0.0136
Schistosoma mansoni	tyrosine kinase	0.012	0.113	0.1439
Entamoeba histolytica	protein kinase, putative	0.0136	0.1303	0.1809
Schistosoma mansoni	hypothetical protein	0.0038	0.0269	0.0343
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.0012	0.0000090706	0.0000090706
Echinococcus multilocularis	pyruvate kinase	0.002	0.0089	0.0089
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.0292	0.0236
Echinococcus granulosus	defective proboscis extension response	0.0022	0.0111	0.0141
Echinococcus multilocularis	muscleblind protein	0.0178	0.174	0.174
Echinococcus multilocularis	microtubule associated protein 2	0.0761	0.7849	0.7849
Onchocerca volvulus		0.0036	0.0256	0.06
Echinococcus granulosus	fetal alzheimer antigen falz	0.0029	0.0177	0.0226
Brugia malayi	serine/threonine kinase 12	0.0136	0.1303	0.3077
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0236	0.0556
Echinococcus multilocularis	pyruvate kinase	0.002	0.0089	0.0089
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0167	0.0042
Echinococcus granulosus	zinc finger protein	0.003	0.0185	0.0235
Echinococcus multilocularis	pyruvate kinase	0.004	0.0292	0.0292
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.025	0.0591
Toxoplasma gondii	pyruvate kinase PyK1	0.004	0.0292	0.167
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.014	0.014
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0639	0.6569	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.025	0.0591
Schistosoma mansoni	cell adhesion molecule	0.0026	0.0143	0.0182
Giardia lamblia	Fructose-bisphosphate aldolase	0.0639	0.6569	1
Echinococcus granulosus	protein quaking	0.0027	0.0159	0.0202
Schistosoma mansoni	pyruvate kinase	0.002	0.0089	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0036	0.025	0.0591
Loa Loa (eye worm)	AUR protein kinase	0.0136	0.1303	0.3077
Echinococcus granulosus	pyruvate kinase	0.002	0.0089	0.0114

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.4 uM	Inhibition of Aurora-A by microplate scintillation counting	ChEMBL.	19692247
IC50 (binding)	= 0.5 uM	Inhibition of Aurora-B by microplate scintillation counting	ChEMBL.	19692247
IC50 (binding)	= 4 uM	Inhibition of TIE2 by microplate scintillation counting	ChEMBL.	19692247
IC50 (binding)	= 9.9 uM	Inhibition of PDGFRbeta by microplate scintillation counting	ChEMBL.	19692247
IC50 (binding)	> 10 uM	Inhibition of wild type EGF-R by microplate scintillation counting	ChEMBL.	19692247
IC50 (binding)	> 10 uM	Inhibition of ERBB2 by microplate scintillation counting	ChEMBL.	19692247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL593971

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1089703