Detailed information for compound 1092187

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.501 | Formula: C28H25NO6
  • H donors: 1 H acceptors: 3 LogP: 5.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1c(C)n(c2c1cccc2)C(=O)c1ccc(cc1C)OC[C@@H]1COc2c(O1)cccc2
  • InChi: 1S/C28H25NO6/c1-17-13-19(33-15-20-16-34-25-9-5-6-10-26(25)35-20)11-12-21(17)28(32)29-18(2)23(14-27(30)31)22-7-3-4-8-24(22)29/h3-13,20H,14-16H2,1-2H3,(H,30,31)/t20-/m1/s1
  • InChiKey: LHONMOULGYVETO-HXUWFJFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus prostaglandin D receptor Starlite/ChEMBL References
Homo sapiens prostaglandin I2 (prostacyclin) receptor (IP) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0084 0.0453
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0062 0.0964 0.4343
Schistosoma mansoni hypothetical protein 0.002 0.0141 0.031
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0035
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0202 0.0584
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0484 0.0617
Schistosoma mansoni rab6-interacting 0.0023 0.0193 0.0466
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0062 0.0964 0.4568
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Brugia malayi cytochrome P450 0.0062 0.0964 0.0909
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2109 0.6252
Leishmania major glucose transporter, lmgt1 0.0038 0.0493 0.2197
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0035
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Loa Loa (eye worm) hypothetical protein 0.003 0.0333 0.03
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0318 0.0362
Loa Loa (eye worm) hypothetical protein 0.0046 0.0647 0.0623
Loa Loa (eye worm) sugar transporter 0.0122 0.216 0.218
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0122 0.216 0.6368
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0039 0.0009
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0589 0.5498
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0484 0.0404
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0062 0.0964 0.4467
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.2022 0.2003
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0062 0.0964 0.4568
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1014 0.9746
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0297 0.0687
Plasmodium vivax SET domain protein, putative 0.0029 0.0318 0.0237
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0589 0.051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Loa Loa (eye worm) cytochrome P450 0.0062 0.0964 0.0948
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1014 0.9746
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1014 0.9746
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0062 0.0964 0.4568
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0469 0.121
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0182 0.3351 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0062 0.0964 0.4343
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0438 0.1116
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0182 0.3351 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0062 0.0964 0.4568
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0493 0.4543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Leishmania major glucose transporter, lmgt3 0.0038 0.0493 0.2197
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0647 0.1752
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.1014 0.2874
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0455 0.2346
Leishmania major protein kinase, putative 0.0037 0.0484 0.2151
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0062 0.0964 0.4568
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0084 0.0035
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0484 0.0455
Trichomonas vaginalis set domain proteins, putative 0.0231 0.4303 1
Mycobacterium leprae putative cytochrome p450 0.0062 0.0964 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0893 0.2503
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0283 0.0739
Leishmania major glucose transporter, lmgt2 0.0038 0.0493 0.2197
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Brugia malayi Bromodomain containing protein 0.0037 0.0481 0.0411
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0156
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0137
Toxoplasma gondii hypothetical protein 0.0018 0.0106 0.0035
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0469 0.2538
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0469 0.0398
Loa Loa (eye worm) hypothetical protein 0.0042 0.0565 0.0538
Loa Loa (eye worm) hypothetical protein 0.0026 0.0255 0.022
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0255 0.0264
Loa Loa (eye worm) calcium channel 0.0182 0.3351 0.3405
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0178 0.0322
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0066 0.104 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0062 0.0964 0.4568
Onchocerca volvulus 0.0036 0.0454 0.0877
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0484 0.1345
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2109 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Echinococcus multilocularis sodium channel protein 0.0047 0.0678 0.1847
Brugia malayi Bromodomain containing protein 0.0073 0.1187 0.114
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0283 0.2446
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0283 1
Echinococcus multilocularis voltage dependent calcium channel 0.0182 0.3351 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2109 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0493 0.4543
Mycobacterium ulcerans sugar transporter 0.0017 0.0084 0.0397
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.044
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0182 0.3351 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0084 0.0035
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Plasmodium vivax CDK-related protein kinase 6, putative 0.0519 1 1
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0589 0.051
Brugia malayi Pre-SET motif family protein 0.0029 0.0318 0.0243
Schistosoma mansoni protein kinase 0.0037 0.0484 0.1345
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0197 0.3649 0.5495
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0484 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0062 0.0964 0.4343
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0062 0.0964 0.4568
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0072 0.0102
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0455 0.2011
Echinococcus multilocularis zinc finger protein 0.0019 0.0121 0.0148
Schistosoma mansoni protein kinase 0.0037 0.0484 0.1345
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0484 0.0413
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0455 0.1167
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0193 0.0368
Trypanosoma brucei sugar transporter, putative 0.0017 0.0084 0.0453
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.375 0.3814
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.2109 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0136 0.2428 0.7186
Onchocerca volvulus 0.0029 0.0318 0.0556
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0062 0.0964 0.4343
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0062 0.0964 0.4343
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0062 0.0964 0.4343
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0193 0.011
Schistosoma mansoni bromodomain containing protein 0.0062 0.0962 0.2788
Loa Loa (eye worm) hypothetical protein 0.0018 0.0106 0.0066
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Schistosoma mansoni inositol monophosphatase 0.0036 0.0455 0.1257
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0438 0.1116
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.2712 0.2747
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0035
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0647 0.1752
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0893 0.2503
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0193 0.0368
Toxoplasma gondii protein kinase, putative 0.0345 0.6571 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.1014 0.1001
Toxoplasma gondii facilitative glucose transporter GT1 0.0122 0.216 0.3201
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0062 0.0964 0.4343
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0484 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0084 0.0453
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.1869 0.188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0647 0.1836
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0193 0.0368
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0455 0.1167
Echinococcus granulosus single minded 2 0.0036 0.0454 0.1163
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0484 0.0948
Schistosoma mansoni lipoxygenase 0.0095 0.1621 0.4776
Loa Loa (eye worm) hypothetical protein 0.0182 0.3351 0.3405
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0035
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0455 0.088
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0062 0.0964 0.9238
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0178 0.0322
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0507 0.9763 1
Schistosoma mansoni rab6-interacting 0.0023 0.0193 0.0466
Schistosoma mansoni polycystin 1-related 0.0023 0.0193 0.0466
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.1014 0.2946
Plasmodium falciparum hexose transporter 0.0122 0.216 0.2094
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0484 0.0404
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0062 0.0964 0.4568
Trypanosoma cruzi hexose transporter 0.0038 0.0493 0.4543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0589 0.2659
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0454 0.1163
Echinococcus granulosus RUN 0.0023 0.0193 0.0368
Echinococcus multilocularis General substrate transporter 0.0105 0.1821 0.5332
Loa Loa (eye worm) voltage-dependent calcium channel 0.0026 0.0255 0.022
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0178 0.0421
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0062 0.0964 0.4568
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0084 0.0035
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0182 0.3351 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0084 0.0453
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0035
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0283 0.1343
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0084 0.0453
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0469 0.0913
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0062 0.0964 0.4343
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0062 0.0964 0.4568
Loa Loa (eye worm) hypothetical protein 0.0027 0.0283 0.0249
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0137
Leishmania major cytochrome p450-like protein 0.0062 0.0964 0.4467
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0217 0.0315
Brugia malayi PAS domain containing protein 0.0048 0.0703 0.064
Mycobacterium leprae Conserved hypothetical protein 0.0062 0.0964 1
Echinococcus granulosus voltage dependent calcium channel 0.0182 0.3351 1
Brugia malayi Pre-SET motif family protein 0.0203 0.375 0.3787
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0493 0.0971
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0182 0.3351 1
Plasmodium falciparum protein kinase 7 0.0345 0.6571 0.6542
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.2022 0.5948
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0283 0.0308
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0062 0.0964 0.4568
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0493 0.0971
Brugia malayi Inositol-1 0.0036 0.0455 0.0383
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.2109 1
Leishmania major protein kinase, putative 0.0015 0.0039 0.0005
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0469 0.3505
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0964 0.9238
Brugia malayi PHD-finger family protein 0.0024 0.0223 0.0144
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0193 0.0368
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0469 0.121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0647 0.1836
Schistosoma mansoni glucose transport protein 0.0122 0.216 0.6405
Entamoeba histolytica protein kinase, putative 0.0037 0.0484 0.2743
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0493 0.4543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Treponema pallidum prolyl-tRNA synthetase 0.0013 0 0.5
Loa Loa (eye worm) CYP4Cod1 0.0062 0.0964 0.0948
Schistosoma mansoni inositol monophosphatase 0.0036 0.0455 0.1257
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0283 0.5182
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0062 0.0964 0.4568
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0493 0.0971
Trypanosoma brucei glucose transporter, putative 0.0038 0.0493 0.4543
Brugia malayi Cytochrome P450 family protein 0.0062 0.0964 0.0909
Entamoeba histolytica protein kinase, putative 0.0037 0.0484 0.2743
Echinococcus multilocularis 0.0062 0.0964 0.2718
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0703 0.2006
Schistosoma mansoni protein kinase 0.0037 0.0484 0.1345
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.1014 0.0962
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0066 0.104 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0182 0.3351 0.3376
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0283 0.1068
Toxoplasma gondii cytochrome p450 superfamily protein 0.0062 0.0964 0.1356
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0062 0.0964 0.4343
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0084 0.0397
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0589 0.0779
Schistosoma mansoni cytochrome P450 0.0062 0.0964 0.2793
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0035
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0062 0.0964 0.4568
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0318 0.0845
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0084 0.0397
Brugia malayi hypothetical protein 0.0023 0.0193 0.0113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0062 0.0964 0.4343
Trypanosoma brucei cytochrome P450, putative 0.0062 0.0964 0.9238
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0283 0.0644
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0062 0.0964 0.4343
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0283 0.0739
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0484 0.0455
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0964 0.0948
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.2109 0.6213
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0589 0.5498
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0484 0.0404
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0455 0.088
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0039 0.0009
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.038 0.2342
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0484 0.0455
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0283 0.0201
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0062 0.0964 0.4343
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0479 0.1242
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0455 0.4158
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0589 0.5498
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0484 0.0617
Schistosoma mansoni hypothetical protein 0.0122 0.216 0.6405
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0484 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0454 0.0382
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0193 0.011
Schistosoma mansoni single-minded 0.0048 0.0703 0.2006
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0047 0.0678 0.1847
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.1014 1
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0469 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0062 0.0964 0.4343
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0964 0.9238
Schistosoma mansoni glucose transport protein 0.0122 0.216 0.6405
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0182 0.3351 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0084 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.216 0.4922
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0493 0.4543
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0283 0.1183
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0062 0.0964 0.4568
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0484 0.0404
Brugia malayi hypothetical protein 0.0023 0.0193 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0493 0.0971
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0493 0.0971
Schistosoma mansoni glucose transport protein 0.0122 0.216 0.6405
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0062 0.0964 0.4343
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0455 0.088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0137
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0062 0.0964 0.4343
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2109 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0493 0.2197
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.2022 0.5989
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0084 0.0043
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0283 0.0473
Leishmania major cytochrome p450-like protein 0.0062 0.0964 0.4467
Loa Loa (eye worm) inositol-1 0.0036 0.0455 0.0425
Leishmania major cytochrome p450-like protein 0.0062 0.0964 0.4467
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0318 0.0751
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0193 0.0368
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.044
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0136 0.2428 0.7186
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0062 0.0964 0.4568
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0137
Schistosoma mansoni hypothetical protein 0.0062 0.0964 0.2793
Echinococcus granulosus cytochrome P450 2K1 0.0062 0.0964 0.2718
Loa Loa (eye worm) hypothetical protein 0.0069 0.1105 0.1094
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0062 0.0964 0.4568
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0062 0.0964 0.4343
Brugia malayi hypothetical protein 0.0163 0.2961 0.2972
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.2109 0.3123
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0283 0.0206
Schistosoma mansoni loxhd1 0.0023 0.0193 0.0466
Loa Loa (eye worm) hypothetical protein 0.0037 0.0482 0.0454
Loa Loa (eye worm) hypothetical protein 0.0163 0.2961 0.3003
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.038 0.1464
Loa Loa (eye worm) hypothetical protein 0.0018 0.0106 0.0066
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0062 0.0964 0.9238
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0493 0.0971
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0469 0.1299
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0182 0.3351 1
Leishmania major hypothetical protein, conserved 0.0017 0.0084 0.0219
Echinococcus multilocularis RUN 0.0023 0.0193 0.0368
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.2022 0.958
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0035
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.1014 0.4713
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0084 0.0137
Schistosoma mansoni hypothetical protein 0.0023 0.0193 0.0466
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0039 0.0009
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.1014 0.2874
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0182 0.3351 1
Onchocerca volvulus 0.0023 0.0193 0.0258
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0283 0.1343
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0436 0.1108
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0182 0.3351 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0283 0.2446
Echinococcus granulosus voltage dependent calcium channel 0.0026 0.0255 0.0558
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0062 0.0964 0.4343
Brugia malayi Sugar transporter family protein 0.0122 0.216 0.2145
Brugia malayi Cytochrome P450 family protein 0.0062 0.0964 0.0909
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0062 0.0964 0.4568
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0062 0.0964 0.9238
Loa Loa (eye worm) hypothetical protein 0.004 0.0528 0.05
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0156
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0084 0.0035
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0454 0.215
Schistosoma mansoni glucose transporter 0.0017 0.0084 0.0137
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0469 0.1299
Leishmania major protein kinase, putative 0.0015 0.0039 0.0005
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0484 0.0404
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0589 0.2659
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0436 0.1108
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368
Onchocerca volvulus 0.0231 0.4303 1
Schistosoma mansoni zinc finger protein 0.0019 0.0121 0.0249
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0062 0.0964 0.4568
Echinococcus granulosus zinc finger protein 0.0019 0.0121 0.0148
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0484 0.0617
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.2022 0.9588
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0197 0.3649 0.3595
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.2022 0.9571
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0039 0.0009
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0193 0.0368
Echinococcus granulosus General substrate transporter 0.0105 0.1821 0.5332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0318 0.0845
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0084 0.0043
Brugia malayi Cytochrome P450 family protein 0.0062 0.0964 0.0909
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0479 0.1242
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0484 0.4448
Brugia malayi Cam kinase protein 1 0.0037 0.0484 0.0413
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0062 0.0964 0.4568
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0062 0.0964 0.4343
Echinococcus multilocularis voltage dependent calcium channel 0.0182 0.3351 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0062 0.0964 0.9238
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0084 0.0397
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.2022 0.5948
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0493 0.4543
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0469 0.0398
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0062 0.0964 0.4343
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.2109 0.6213
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0072 0.0102
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0062 0.0964 0.4568
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0484 0.1256
Loa Loa (eye worm) sugar transporter 0.0017 0.0084 0.0043
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0062 0.0964 0.4568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0084 0.0044
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0484 0.0404
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0141 0.0102
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2109 0.6252
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0964 0.0948
Plasmodium falciparum mitogen-activated protein kinase 2 0.0197 0.3649 0.3595
Trypanosoma brucei glucose transporter 2A 0.0038 0.0493 0.4543
Onchocerca volvulus 0.0023 0.0193 0.0258
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0455 0.4158
Brugia malayi hypoxia-induced factor 1 0.015 0.2712 0.2715
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0043
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0062 0.0964 0.4343
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0455 0.2156
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0484 0.1256
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0154 0.115
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0193 0.0156
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0455 0.4158
Brugia malayi Cytochrome P450 family protein 0.0206 0.381 0.385
Schistosoma mansoni voltage-gated cation channel 0.0182 0.3351 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0283 0.0201
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.2022 0.9588
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0455 0.0572
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0493 0.4543
Schistosoma mansoni lipoxygenase 0.0136 0.2428 0.7214
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0283 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0493 0.0971
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0202 0.0584
Trypanosoma brucei glucose transporter 1E 0.0038 0.0493 0.4543
Plasmodium vivax hexose transporter 0.0122 0.216 0.2094
Brugia malayi follicle stimulating hormone receptor 0.0507 0.9763 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0206 0.381 0.3876
Brugia malayi Doublecortin family protein 0.0023 0.0193 0.0113
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.216 0.6368

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.8 nM Antagonist activity at mouse DP receptor expressed in CHO cells assessed as inhibition of PGD2-induced cAMP accumulation after 10 mins by enzyme immunoassay in the presence of 0.1% BSA ChEMBL. 21737285
Ki (binding) = 22 nM Displacement of [3H]-PGD2 from mouse DP receptor expressed in CHO cells after 20 mins by liquid scintillation counting ChEMBL. 21737285
Ki (binding) = 570 nM Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting ChEMBL. 21737285

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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