Detailed information for compound 1103320

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.381 | Formula: C21H30Cl2N2O2
  • H donors: 0 H acceptors: 1 LogP: 4.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)OCCCC(=O)N([C@H]1CCCC[C@H]1N1CCCC1)C
  • InChi: 1S/C21H30Cl2N2O2/c1-24(18-7-2-3-8-19(18)25-12-4-5-13-25)21(26)9-6-14-27-20-11-10-16(22)15-17(20)23/h10-11,15,18-19H,2-9,12-14H2,1H3/t18-,19+/m0/s1
  • InChiKey: RQIUSCCNFMWMFJ-RBUKOAKNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0156 0.0236 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.5692 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0445 0.0746 0.073
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.0172 0.0156
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0022 0.0017
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1952 0.3404 0.3389
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.0745 0.0725
Plasmodium falciparum phosphatidylinositol 3-kinase 0.04 0.0667 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Echinococcus multilocularis beta LACTamase domain containing family member 0.014 0.0209 0.0209
Schistosoma mansoni phosphatidylinositol 4-kinase 0.04 0.0667 0.0667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0167 0.1006
Brugia malayi beta-lactamase family protein 0.014 0.0209 0.0205
Brugia malayi beta-lactamase family protein 0.014 0.0209 0.0205
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0293 0.0477 0.0461
Onchocerca volvulus 0.0142 0.0212 0.3235
Onchocerca volvulus 0.0117 0.0167 0.25
Mycobacterium ulcerans lipase LipD 0.014 0.0209 0.2103
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Loa Loa (eye worm) hypothetical protein 0.0156 0.0236 0.022
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.0745 0.0742
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0064 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0167 0.1634
Schistosoma mansoni bromodomain containing protein 0.0062 0.007 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0738 0.1262 0.1247
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0378 0.0629 0.94
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0172 0.0151
Brugia malayi FAT domain containing protein 0.0843 0.1448 0.1444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0156 0.0236 0.0232
Entamoeba histolytica hypothetical protein 0.0378 0.0629 0.0608
Entamoeba histolytica hypothetical protein 0.1097 0.1896 0.1878
Echinococcus multilocularis 0.0378 0.0629 0.0629
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149 0.0224 0.0207
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.04 0.0667 1
Entamoeba histolytica hypothetical protein 0.0546 0.0923 0.0904
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0445 0.0746 0.0726
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.059 0.1002 0.0982
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0183 0.0167
Schistosoma mansoni acetyl-CoA synthetase 0.0034 0.0022 0.0022
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5692 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.014 0.0209 0.1278
Mycobacterium tuberculosis Probable hydrolase 0.014 0.0209 0.1278
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0117 0.0167 0.1634
Toxoplasma gondii FATC domain-containing protein 0.1097 0.1896 0.2532
Loa Loa (eye worm) hypothetical protein 0.0103 0.0143 0.0127
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.9408
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4542 0.7971 0.7967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0629 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.012 0.0172 0.2432
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.04 0.0667 0.0663
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0513 0.0866 0.0866
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5692 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0022 0.0005
Onchocerca volvulus 0.014 0.0209 0.3177
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1097 0.1896 0.1896
Mycobacterium tuberculosis Conserved protein 0.014 0.0209 0.1278
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.04 0.0667 0.0667
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Trypanosoma cruzi target of rapamycin kinase 3 0.4542 0.7971 0.7967
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.9408
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0103 0.0143 0.0143
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.04 0.0667 0.0652
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0042 0.0038
Brugia malayi RNA binding protein 0.0126 0.0183 0.0179
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.1896 0.1882
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2684 0.4695 0.4683
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0183 0.0183
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0159 0.0242 0.0238
Echinococcus multilocularis tumor protein p63 0.0987 0.1702 0.1702
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.012 0.0172 0.0172
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0017 0.0017
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0034 0.0022 0.0022
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Mycobacterium ulcerans beta-lactamase 0.014 0.0209 0.2103
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0378 0.0629 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Schistosoma mansoni glutaminase 0.0539 0.0911 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.1228 0.1214
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0268 0.0268
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0121 0.0104
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Mycobacterium leprae conserved hypothetical protein 0.0378 0.0629 1
Onchocerca volvulus 0.0034 0.0022 0.0136
Schistosoma mansoni survival motor neuron protein 0.0142 0.0212 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0718 0.1228 0.1214
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1097 0.1896 0.1896
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0445 0.0746 0.0726
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0172 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.309 0.5412 0.5404
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Schistosoma mansoni hypothetical protein 0.0843 0.1448 0.1448
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0034 0.0022 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0167 0.1634
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0167 0.0146
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0378 0.0629 0.0613
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0445 0.0746 0.0746
Loa Loa (eye worm) phosphatidylinositol 3 0.5692 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1996 0.3481 0.3481
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0513 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0126 0.0183 0.0166
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1097 0.1896 0.1878
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0017 0.0017
Mycobacterium leprae conserved hypothetical protein 0.014 0.0209 0.3082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0121 0.0121
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0117 0.0167 0.1634
Echinococcus granulosus beta LACTamase domain containing family member 0.014 0.0209 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0629 0.0613
Schistosoma mansoni cellular tumor antigen P53 0.0144 0.0216 0.0216
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0843 0.1448 0.1448
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.014 0.0209 0.2103
Echinococcus multilocularis fk506 binding protein 0.012 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Echinococcus multilocularis protein dispatched 1 0.0143 0.0214 0.0214
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.3387 0.5934 0.5927
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0167 0.0146
Trichomonas vaginalis immunophilin, putative 0.012 0.0172 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0167 0.0146
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0522 0.0881 0.0866
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0087 0.0115 0.105
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0167 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0214 0.0339 0.0339
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0017 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0209 0.0192
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0172 0.0151
Echinococcus granulosus tumor protein p63 0.0987 0.1702 0.1702
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0209 0.0209
Loa Loa (eye worm) FKBP5 protein 0.012 0.0172 0.0156
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0664 0.1132 0.1132
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0087 0.0115 0.0665
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0121 0.0121
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0042 0.0042
Leishmania major phosphatidylinositol 3-kinase, putative 0.04 0.0667 0.0647
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.014 0.0209 0.2103
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Loa Loa (eye worm) hypothetical protein 0.0493 0.083 0.0815
Schistosoma mansoni fkbp-rapamycin associated protein 0.1097 0.1896 0.1896
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.059 0.1002 0.0987
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0378 0.0629 0.0629
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.059 0.1002 0.0987
Brugia malayi Niemann-Pick C1 protein precursor 0.0293 0.0477 0.0473
Entamoeba histolytica protein kinase rad3, putative 0.1097 0.1896 0.1878
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Mycobacterium tuberculosis Probable conserved lipoprotein 0.014 0.0209 0.1278
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0139 0.0118
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0023 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0209 0.0192
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5692 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0718 0.1228 0.1209
Plasmodium vivax acetyl-CoA synthetase, putative 0.0034 0.0022 0.0128
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.04 0.0667 0.088
Loa Loa (eye worm) hypothetical protein 0.1222 0.2115 0.2102
Brugia malayi Latrophilin receptor protein 2 0.0156 0.0236 0.0232
Leishmania major phosphatidylinositol 3-kinase, putative 0.194 0.3383 0.3368
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0209 0.0192
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0005 0.0005
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0017 0.0017
Echinococcus granulosus serine protein kinase ATM 0.1097 0.1896 0.1896
Mycobacterium tuberculosis Conserved hypothetical protein 0.0378 0.0629 0.4023
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Trichomonas vaginalis PIKK family atypical protein kinase 0.3819 0.6696 0.669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0629 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0121 0.0121
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0078 0.0062
Echinococcus granulosus Niemann Pick C1 protein 0.0418 0.0699 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Onchocerca volvulus 0.0034 0.0022 0.0136
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0477 0.0803 0.0642
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0445 0.0746 0.073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0042 0.0026
Leishmania major fk506-binding protein 1-like protein 0.012 0.0172 0.0151
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0192 0.03 0.0296
Giardia lamblia Phosphatidylinositol 4-kinase 0.0378 0.0629 0.0464
Trichomonas vaginalis antibiotic synthetase, putative 0.0034 0.0022 0.0005
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.194 0.3383 0.3368
Schistosoma mansoni immunophilin 0.012 0.0172 0.0172
Trichomonas vaginalis fk506-binding protein, putative 0.012 0.0172 0.0156
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0378 0.0629 0.0608
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0209 0.0192
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0214 0.0339 0.0339
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0378 0.0629 0.0608
Loa Loa (eye worm) hypothetical protein 0.004 0.0031 0.0015
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Mycobacterium ulcerans glutaminase 0.0539 0.0911 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.0172 0.0156
Loa Loa (eye worm) glutaminase 0.0539 0.0911 0.0896
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0378 0.0629 0.0608
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0017 0.0013
Loa Loa (eye worm) RNA binding protein 0.0126 0.0183 0.0167
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1996 0.3481 0.3467
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0159 0.0242 0.0226
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0117 0.0167 0.1634
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2406 0.4204 0.4204
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0017 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0469 0.0788 0.0768
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.059 0.1002 0.0982
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2377 0.4153 0.414
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Onchocerca volvulus 0.0034 0.0022 0.0136
Toxoplasma gondii propionate-CoA ligase 0.0034 0.0022 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Brugia malayi Calcitonin receptor-like protein seb-1 0.0493 0.083 0.0826
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0378 0.0629 0.0629
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0268 0.0268
Entamoeba histolytica hypothetical protein 0.0378 0.0629 0.0608
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1097 0.1896 0.1878
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1097 0.1896 0.1892
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0183 0.0167
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4542 0.7971 0.7967
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0034 0.0022 0.0022
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0445 0.0746 0.073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0156 0.0236 0.022
Onchocerca volvulus 0.0378 0.0629 1
Echinococcus multilocularis expressed conserved protein 0.0275 0.0446 0.0446
Echinococcus multilocularis microtubule associated protein 2 0.2729 0.4774 0.4774
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Schistosoma mansoni immunophilin 0.0103 0.0143 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0159 0.0242 0.0242
Echinococcus multilocularis serine protein kinase ATM 0.1097 0.1896 0.1896
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0378 0.0629 0.0828
Loa Loa (eye worm) hypothetical protein 0.0138 0.0205 0.0189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0493 0.083 0.0815
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.04 0.0667 0.0652
Brugia malayi glutaminase DH11.1 0.0539 0.0911 0.0908
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0423 0.0707 0.0544
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1109 0.1917 0.1899
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1952 0.3404 0.3389
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0034 0.0022 0.0055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0156 0.0236 0.0236
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.3694 0.6476 0.647
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0042 0.0042
Entamoeba histolytica acyl-coA synthetase, putative 0.0117 0.0167 0.0146
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0172 0.0151
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5692 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0183 0.0166
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0156 0.0236 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1996 0.3481 0.3479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0043 0.0043
Echinococcus multilocularis Niemann Pick C1 protein 0.0293 0.0477 0.0477
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0043 0.0043
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0522 0.0881 0.0866
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0121 0.0121
Brugia malayi hypothetical protein 0.0214 0.0339 0.0335
Schistosoma mansoni microtubule-associated protein tau 0.2729 0.4774 0.4774
Onchocerca volvulus 0.0034 0.0022 0.0136
Loa Loa (eye worm) hypothetical protein 0.0117 0.0167 0.0151
Trichomonas vaginalis esterase, putative 0.014 0.0209 0.0192
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0172 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.1952 0.3404 0.3393
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5692 1 1
Loa Loa (eye worm) hypothetical protein 0.0513 0.0866 0.0851
Loa Loa (eye worm) hypothetical protein 0.0843 0.1448 0.1434
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0121 0.0117
Leishmania major hypothetical protein, unknown function 0.0378 0.0629 0.0608
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0209 0.0192
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0034 0.0022 0.0055
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Brugia malayi CHE-14 protein 0.0126 0.0183 0.0179
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0142 0.0212 0.0208
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.012 0.0172 0.0168
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0005 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0167 0.0146
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.014 0.0209 0.1278
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0183 0.0183
Giardia lamblia GTOR 0.5692 1 1
Brugia malayi Bromodomain containing protein 0.0073 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.0154 0.0232 0.0216
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.04 0.0667 0.0647
Loa Loa (eye worm) hypothetical protein 0.0034 0.0022 0.0005
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.012 0.0172 0.1694
Trypanosoma brucei hypothetical protein, conserved 0.014 0.0209 0.0188
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0067 0.0078 0.0057
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0034 0.0022 0.0011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5692 1 1
Schistosoma mansoni hypothetical protein 0.0214 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Onchocerca volvulus 0.014 0.0209 0.3177
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0034 0.0022 0.0055
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0087 0.0115 0.5
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.012 0.0172 0.0172
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0378 0.0629 0.0828
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0183 0.0179
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0183 0.0183
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0212 0.0334 0.0314
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0324 0.0308
Loa Loa (eye worm) phosphatidylinositol kinase 0.0378 0.0629 0.0613
Trichomonas vaginalis antibiotic synthetase, putative 0.0034 0.0022 0.0005
Toxoplasma gondii target of rapamycin (TOR), putative 0.4246 0.7449 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0117 0.0167 0.1634
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0043 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0513 0.0866 0.0863
Echinococcus granulosus microtubule associated protein 2 0.2729 0.4774 0.4774
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.5962 0.5955
Brugia malayi Pre-SET motif family protein 0.003 0.0013 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.309 0.5412 0.5404
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.012 0.0172 0.0151
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0034 0.0022 0.0055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.014 0.0209 0.0205
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0293 0.0477 0.0457
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0843 0.1448 0.1448
Loa Loa (eye worm) oxidoreductase 0.0034 0.0022 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.1109 0.1917 0.1903
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0167 0.0163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0629 0.0625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.1952 0.3404 0.3393
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0172 0.0151
Mycobacterium tuberculosis Probable esterase LipL 0.014 0.0209 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0337 0.0555 0.0539
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0374 0.0358
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0159 0.0242 0.0242
Schistosoma mansoni hypothetical protein 0.0378 0.0629 0.0629
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.059 0.1002 0.0987
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.04 0.0667 0.0647
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.012 0.0172 0.0156
Onchocerca volvulus 0.014 0.0209 0.3177
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149 0.0224 0.0207
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.04 0.0667 0.0652
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1996 0.3481 0.3481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1097 0.1896 0.1892
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5692 1 1
Loa Loa (eye worm) hypothetical protein 0.1097 0.1896 0.1882
Toxoplasma gondii ABC1 family protein 0.014 0.0209 0.0263
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0297 0.0485 0.0485
Mycobacterium tuberculosis Conserved protein 0.014 0.0209 0.1278
Giardia lamblia Hypothetical protein 0.0378 0.0629 0.0464
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5692 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1097 0.1896 0.1896
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0782 0.1341 0.1341
Mycobacterium ulcerans hypothetical protein 0.0117 0.0167 0.1634
Loa Loa (eye worm) hypothetical protein 0.0227 0.0362 0.0346
Echinococcus multilocularis Zinc finger, PHD finger 0.04 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0077 0.0097 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0209 0.0209
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.012 0.0172 0.5
Schistosoma mansoni immunophilin 0.012 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.5962 0.5955
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0897 0.1543 1
Brugia malayi hypothetical protein 0.0698 0.1192 0.1189
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0629 0.0625
Loa Loa (eye worm) glutaminase 2 0.0539 0.0911 0.0896
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0034 0.0022 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0011 0.0011
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.04 0.0667 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.3387 0.5934 0.5927
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0378 0.0629 0.9408
Loa Loa (eye worm) hypothetical protein 0.0698 0.1192 0.1178
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0209 0.0188
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0034 0.0022 0.0017
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.0745 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.4849 0.8513 0.8511
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0034 0.0022 0.0055
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Schistosoma mansoni patched 1 0.0126 0.0183 0.0183
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0445 0.0746 0.0726
Brugia malayi Bromodomain containing protein 0.0037 0.0027 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0493 0.083 0.0826
Loa Loa (eye worm) hypothetical protein 0.0117 0.0167 0.0151
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0445 0.0746 0.0742
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.012 0.0172 0.0151
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0378 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Trichomonas vaginalis conserved hypothetical protein 0.0843 0.1448 0.1434
Trichomonas vaginalis conserved hypothetical protein 0.1222 0.2115 0.2102
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0664 0.1132 0.1132
Onchocerca volvulus 0.0234 0.0374 0.5866
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0782 0.1341 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.1529 0.2658 0.2645
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0042 0.0042
Echinococcus multilocularis GPCR, family 2 0.0156 0.0236 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0378 0.0629 0.9408
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0183 0.0183
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.014 0.0209 0.0192
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0156 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.115 0.199 0.1977
Loa Loa (eye worm) hypothetical protein 0.0144 0.0216 0.02
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Leishmania major peptidylprolyl isomerase-like protein 0.012 0.0172 0.0151
Echinococcus multilocularis Niemann Pick C1 protein 0.0418 0.0699 0.0699
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0018
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1222 0.2115 0.2827
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0167 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0378 0.0629 0.94
Mycobacterium tuberculosis Conserved protein 0.014 0.0209 0.1278
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Onchocerca volvulus 0.0144 0.0216 0.3294
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0378 0.0629 0.0629
Echinococcus granulosus expressed conserved protein 0.0275 0.0446 0.0446
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0782 0.1341 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.012 0.0172 0.0172
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0167 0.1634
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0378 0.0629 0.0828
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.309 0.5412 0.5404
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.1896 0.1882
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1996 0.3481 0.3467
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0209 0.0188
Brugia malayi TAR-binding protein 0.0126 0.0183 0.0179
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0017 0.0017
Plasmodium vivax hypothetical protein, conserved 0.014 0.0209 0.2989
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0183 0.0166
Plasmodium vivax hypothetical protein 0.0378 0.0629 0.9408
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.04 0.0667 0.0667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Loa Loa (eye worm) hypothetical protein 0.0378 0.0629 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1097 0.1896 0.1878
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.012 0.0172 0.2334
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0378 0.0629 0.0613
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.012 0.0172 0.0172
Mycobacterium tuberculosis Probable lipase LipE 0.014 0.0209 0.1278
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0142 0.0212 0.0212
Onchocerca volvulus 0.0378 0.0629 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0034 0.0022 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5692 1 1
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Echinococcus multilocularis survival motor neuron protein 1 0.0698 0.1192 0.1192
Leishmania major phosphatidylinositol kinase, putative 0.0378 0.0629 0.0608
Loa Loa (eye worm) hypothetical protein 0.0718 0.1228 0.1214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0121 0.0121
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0034 0.0022 0.0055
Echinococcus granulosus tar DNA binding protein 0.0126 0.0183 0.0183
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0117 0.0167 0.1006
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.5692 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.5962 0.5955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0121 0.0121
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0337 0.0555 0.0555
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Leishmania major hypothetical protein, conserved 0.014 0.0209 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.5692 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.059 0.1002 0.0998
Mycobacterium leprae Probable lipase LipE 0.014 0.0209 0.3082
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0117 0.0167 0.2396
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0017 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0214 0.0339 0.0339
Brugia malayi latrophilin 2 splice variant baaae 0.0337 0.0555 0.0551
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0445 0.0746 0.0726
Echinococcus granulosus survival motor neuron protein 1 0.0698 0.1192 0.1192
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.04 0.0667 0.088
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.04 0.0667 0.0667
Mycobacterium tuberculosis Probable lipase LipD 0.014 0.0209 0.1278
Brugia malayi Pre-SET motif family protein 0.0206 0.0324 0.032
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0034 0.0022 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0121 0.0121
Brugia malayi beta-lactamase 0.014 0.0209 0.0205
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0378 0.0629 0.0608
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.059 0.1002 0.0982
Leishmania major hypothetical protein, conserved 0.048 0.0807 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Loa Loa (eye worm) hypothetical protein 0.0117 0.0167 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0069 0.0083 0.0067
Echinococcus multilocularis protein patched 0.0126 0.0183 0.0183
Trichomonas vaginalis glutaminase, putative 0.0539 0.0911 0.0896
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0017 0.0017
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1996 0.3481 0.3481
Echinococcus granulosus GPCR family 2 0.0156 0.0236 0.0236
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0103 0.0143 0.0143
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5692 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0013 0.0013
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.04 0.0667 0.0652
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0042 0.0042
Loa Loa (eye worm) beta-lactamase 0.014 0.0209 0.0192
Leishmania major phosphatidylinositol kinase related protein, putative 0.0378 0.0629 0.0608
Echinococcus granulosus Niemann Pick C1 protein 0.0293 0.0477 0.0477
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.0745 0.0725
Mycobacterium ulcerans hypothetical protein 0.014 0.0209 0.2103
Plasmodium vivax acyl-CoA synthetase, putative 0.0087 0.0115 0.1556
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.012 0.0172 0.0168
Loa Loa (eye worm) hypothetical protein 0.0445 0.0745 0.073
Entamoeba histolytica hypothetical protein 0.0378 0.0629 0.0608
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0117 0.0167 0.2396
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0167 0.0163
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5692 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0546 0.0923 0.0904
Plasmodium falciparum acyl-CoA synthetase 0.0087 0.0115 0.1446

Activities

Activity type Activity value Assay description Source Reference
Control (binding) = 43.37 % Binding affinity against opioid receptor kappa 1 using [3H]U-69,593 as a radioligand ChEMBL. 2172538
Control (binding) = 88.16 % Binding affinity against opioid receptor kappa 1 using with [3H]-bremazocine as radioligand ChEMBL. 2172538
IC50 (binding) = 418 nM Binding affinity for sigma opioid receptor using [3H]-(+)-3-PPP as radioligand ChEMBL. 2172538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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