Detailed information for compound 1131686

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.504 | Formula: C28H24F3N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)c1cccc(c1)C(F)(F)F)N1CCN([C@H](C1)C)C(=O)c1ccc2c(c1)[nH]cc2
  • InChi: 1S/C28H24F3N3O2/c1-18-17-33(13-14-34(18)27(36)23-10-7-20-11-12-32-25(20)16-23)26(35)21-8-5-19(6-9-21)22-3-2-4-24(15-22)28(29,30)31/h2-12,15-16,18,32H,13-14,17H2,1H3/t18-/m0/s1
  • InChiKey: MYYHPWVXRPLYMD-SFHVURJKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens growth hormone secretagogue receptor Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2A Starlite/ChEMBL References
Homo sapiens histamine receptor H2 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 3 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Schistosoma mansoni rhodopsin-like orphan GPCR growth hormone secretagogue receptor 289 aa 243 aa 23.1 %
Brugia malayi hypothetical protein histamine receptor H2 397 aa 333 aa 23.1 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0138 0.0138
Brugia malayi ORL1-like opioid receptor 0.0029 0.0138 0.0215
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0138 0.0138
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0138 0.0138
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0138 0.0138
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0138 0.0138
Brugia malayi PHD-finger family protein 0.0024 0.0086 0.0135
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0088 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0041 0.0281 0.0281
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0374 0.0374
Loa Loa (eye worm) serotonin transporter b 0.0292 0.3118 0.3118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0348 0.6846
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0088 0.0808 0.0808
Echinococcus multilocularis sex peptide receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0123 0.1209 0.1208
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.3118 0.3118
Loa Loa (eye worm) hypothetical protein 0.0088 0.0808 0.0808
Echinococcus multilocularis serotonin receptor 0.0029 0.0138 0.0138
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0123 0.1209 0.1881
Schistosoma mansoni neuropeptide receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0138 0.0138
Plasmodium vivax amine transporter, putative 0.005 0.0374 0.4631
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0138 0.0215
Brugia malayi diacylglycerol acyltransferase 0.0088 0.0808 0.1258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni neuropeptide receptor 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1042 0.8837
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0088 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0529 0.5797 0.5797
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Brugia malayi Serotonin receptor 0.0584 0.6425 1
Plasmodium falciparum transporter, putative 0.005 0.0374 0.4631
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0138 0.0138
Schistosoma mansoni opsin-like receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) glutathione reductase 0.0048 0.0352 0.0352
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0914 0.1423
Echinococcus granulosus fmrfamide receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.888 0.888
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.09 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0138 0.0138
Toxoplasma gondii hypothetical protein 0.005 0.0374 0.4631
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0088 0.0808 0.0808
Trypanosoma cruzi glycerol uptake protein, putative 0.0088 0.0808 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0374 0.0374
Schistosoma mansoni histamine h1 receptor 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0191 0.1623
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis serotonin receptor 0.0029 0.0138 0.0138
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1179 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0363 0.0363
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0138 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0348 0.6846
Schistosoma mansoni hypothetical protein 0.004 0.0269 0.0269
Schistosoma mansoni amine GPCR 0.0029 0.0138 0.0138
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0138 0.0138
Toxoplasma gondii hypothetical protein 0.005 0.0374 0.4631
Schistosoma mansoni adenoreceptor 0.0029 0.0138 0.0138
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0138 0.0215
Echinococcus granulosus g protein coupled receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0213
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0138 0.0138
Brugia malayi Dopamine receptor 0.0029 0.0138 0.0215
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Echinococcus granulosus neuropeptide receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Trypanosoma cruzi GUP1, putative 0.0088 0.0808 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0348 0.6846
Mycobacterium tuberculosis Probable reductase 0.0109 0.1042 0.8837
Onchocerca volvulus 0.0029 0.0138 0.0266
Schistosoma mansoni hypothetical protein 0.002 0.004 0.004
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0213 0.2638
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis protein dispatched 1 0.0048 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0069 0.0589 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0348 0.6846
Onchocerca volvulus 0.0029 0.0138 0.0266
Loa Loa (eye worm) hypothetical protein 0.0088 0.0808 0.0808
Onchocerca volvulus 0.0029 0.0138 0.0266
Schistosoma mansoni zinc finger protein 0.0019 0.0028 0.0028
Onchocerca volvulus 0.0292 0.3118 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.0583
Loa Loa (eye worm) hhat protein 0.0088 0.0808 0.0808
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0088 0.0808 0.0808
Echinococcus granulosus allatostatin A receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0138 0.0138
Brugia malayi MBOAT family protein 0.0088 0.0808 0.1258
Schistosoma mansoni opsin-like receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0286 0.0285
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0088 0.0808 0.8468
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus o acyltransferase membrane bound domain 0.0088 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0138 0.0138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0334 0.0334
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0213
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0374 0.0583
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0374 0.0374
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0088 0.0808 0.0808
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0088 0.0808 1
Schistosoma mansoni myosin xvIII 0.0029 0.0138 0.0138
Brugia malayi neuropeptide F receptor 0.0029 0.0138 0.0215
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Echinococcus granulosus hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0374 0.0374
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0138 0.0138
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0088 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0292 0.3118 0.3118
Leishmania major glycerol uptake protein, putative 0.0088 0.0808 1
Schistosoma mansoni hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0138 0.0138
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0374 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0808 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1179 1
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0423 0.0422
Echinococcus multilocularis zinc finger protein 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0088 0.0808 0.0808
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0334 0.0334
Schistosoma mansoni opsin-like receptor 0.0029 0.0138 0.0138
Onchocerca volvulus 0.005 0.0374 0.1037
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0348 0.0542
Schistosoma mansoni amine GPCR 0.0229 0.2402 0.2402
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0374 0.0374
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0138 0.0138
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0468 0.0468
Trypanosoma brucei glycerol uptake protein, putative 0.0088 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0138 0.0138
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.4631
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0138 0.0138
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0138 0.0138
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0138 0.0138
Echinococcus granulosus sex peptide receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0808 1
Trypanosoma brucei glycerol uptake protein, putative 0.0088 0.0808 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0931 0.0931
Onchocerca volvulus 0.0029 0.0138 0.0266
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0088 0.0808 0.0808
Plasmodium falciparum amino acid transporter, putative 0.005 0.0374 0.4631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Onchocerca volvulus 0.0047 0.0348 0.0953
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0138 0.0138
Trypanosoma cruzi GUP1, putative 0.0088 0.0808 1
Brugia malayi GnHR receptor homolog 0.0029 0.0138 0.0215
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0088 0.0808 0.0808
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0509 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0374 0.0374
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0088 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.004 0.0269 0.0269
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0138 0.0138
Brugia malayi RE15519p 0.0029 0.0138 0.0215
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0138 0.0138
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0088 0.0808 0.0808
Schistosoma mansoni biogenic amine receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Brugia malayi MBOAT family protein 0.0088 0.0808 0.1258
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0061 0.0061
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0138 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0348 0.1814
Echinococcus granulosus somatostatin receptor 0.0029 0.0138 0.0138
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0097 0.0914 0.0914
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1179 1
Onchocerca volvulus 0.0029 0.0138 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0348 0.2956
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.0583
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1042 0.8837
Brugia malayi sulfakinin receptor protein 0.0029 0.0138 0.0215
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0509 0.0509
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0138 0.0138
Leishmania major hypothetical protein, conserved 0.0088 0.0808 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0352 0.0352
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0468 0.0468
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.005 0.0374 0.0583
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1387 0.1387
Trypanosoma cruzi glycerol uptake protein, putative 0.0088 0.0808 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0088 0.0808 0.0808
Onchocerca volvulus Huntingtin homolog 0.0123 0.1209 0.3763
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0138 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0292 0.3118 0.3118
Toxoplasma gondii thioredoxin reductase 0.0048 0.0352 0.4353
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0138 0.0138
Echinococcus granulosus o acyltransferase membrane bound domain 0.0088 0.0808 0.0808
Brugia malayi MBOAT family protein 0.0088 0.0808 0.1258
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0213
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0374 0.0374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0812 0.9005 0.9005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0348
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1042 0.8837
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0348 0.2956
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0352 0.4353
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0348 0.6846
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.4631
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0292 0.3118 0.3118
Brugia malayi Dopamine receptor protein 1 0.0029 0.0138 0.0215
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus serotonin receptor 0.0029 0.0138 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0348 0.4311
Brugia malayi glutathione reductase 0.0048 0.0352 0.0548
Loa Loa (eye worm) hhat protein 0.0088 0.0808 0.0808
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0348 0.6846
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0348 0.4311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Leishmania major glycerol uptake protein, putative 0.0088 0.0808 1
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0213 0.2638
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0088 0.0808 0.0808
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0138 0.0138
Echinococcus granulosus expressed conserved protein 0.0091 0.0847 0.0847
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0138 0.0138
Loa Loa (eye worm) MBOAT family protein 0.0088 0.0808 0.0808
Onchocerca volvulus 0.0029 0.0138 0.0266
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0223 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0348 0.0542
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0213 0.1809
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0138 0.0138
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0138 0.0138
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.004 0.0269 0.0269
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0207 0.0207
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0374 0.0374
Onchocerca volvulus 0.005 0.0374 0.1037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Leishmania major glycerol uptake protein, putative 0.0088 0.0808 1
Brugia malayi CHE-14 protein 0.0042 0.0286 0.0445
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0138 0.0138
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0138 0.0138
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0138 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0334 0.0334
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.0583
Echinococcus granulosus serotonin transporter 0.0292 0.3118 0.3118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0334 0.0334
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0138 0.0266
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0138 0.0138
Trichomonas vaginalis porcupine, putative 0.0088 0.0808 1
Leishmania major trypanothione reductase 0.0048 0.0352 0.4353
Brugia malayi Thioredoxin reductase 0.0048 0.0352 0.0548
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0036 0.0223 0.0223
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0029 0.0138 0.0138
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.3118 0.4852
Brugia malayi G-protein coupled receptor 0.0029 0.0138 0.0215
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1179 1
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0138 0.0138
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0138 0.0215
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1042 0.8837
Plasmodium falciparum glutathione reductase 0.0048 0.0352 0.4353
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0088 0.0808 0.0808
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0138 0.0138
Schistosoma mansoni zinc finger protein 0.0088 0.0808 0.0808
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0191 0.1623
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0374 0.0374
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0352 0.2985
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0374 0.0374
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0213 0.4189
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Onchocerca volvulus 0.0029 0.0138 0.0266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0238 0.2506 0.2506
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0348 0.0542
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0138 0.0266
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0138 0.0138
Onchocerca volvulus 0.0029 0.0138 0.0266
Loa Loa (eye worm) hypothetical protein 0.0529 0.5797 0.5797
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Schistosoma mansoni bromodomain containing protein 0.0061 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Entamoeba histolytica vacuolar protein sorting 26 0.0088 0.0808 0.8468
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0374 0.0374
Onchocerca volvulus 0.0029 0.0138 0.0266
Echinococcus granulosus g protein coupled receptor 0.0029 0.0138 0.0138
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.4631
Brugia malayi putative neuropeptide receptor 0.0029 0.0138 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0049 0.0363 0.0363
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0238 0.2506 0.3901
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0509 0.0509
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0808 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0088 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0213
Brugia malayi AKH receptor 0.0029 0.0138 0.0215
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0223 0.0223
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0223 0.0223
Echinococcus granulosus o acyltransferase membrane bound domain 0.0088 0.0808 0.0808
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis sterol O acyltransferase 1 0.09 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0374 0.0374
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.0374
Schistosoma mansoni biogenic amine receptor 0.0029 0.0138 0.0138
Brugia malayi Serotonin receptor 0.0029 0.0138 0.0215
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0051 0.0392 0.0392
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0352 0.0352
Brugia malayi G-protein coupled receptor 0.0029 0.0138 0.0215
Entamoeba histolytica hypothetical protein, conserved 0.0088 0.0808 0.8468
Onchocerca volvulus 0.0049 0.0363 0.0999
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0088 0.0808 0.8468
Trypanosoma brucei trypanothione reductase 0.0048 0.0352 0.4353
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0138 0.0138
Plasmodium vivax glutathione reductase, putative 0.0048 0.0352 0.4353
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0088 0.0808 0.0808
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0088 0.0808 0.8468
Brugia malayi Bromodomain containing protein 0.0037 0.0233 0.0363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1042 0.8837
Loa Loa (eye worm) hypothetical protein 0.0123 0.1209 0.1208
Echinococcus multilocularis serotonin transporter 0.0292 0.3118 0.3118
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0374 0.0374
Echinococcus multilocularis protein patched 0.0042 0.0286 0.0286
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0138 0.0138
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0286 0.0286
Echinococcus granulosus zinc finger protein 0.0019 0.0028 0.0028
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0374 0.0374
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0348 0.1814
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0138 0.0138
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0138 0.0138
Brugia malayi Dopamine receptor protein 2 0.0029 0.0138 0.0215
Brugia malayi Hhat protein 0.0088 0.0808 0.1258
Onchocerca volvulus 0.0088 0.0808 0.2455
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0207 0.0207
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0348 0.1814
Schistosoma mansoni neuropeptide receptor 0.0029 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0088 0.0808 0.0808
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi Melatonin receptor type 1A 0.0029 0.0138 0.0215
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0374 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0363 0.0564
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) MBOAT family protein 0.0088 0.0808 0.0808
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1387 0.1387
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0088 0.0808 0.0808
Echinococcus granulosus orexin receptor type 2 0.0029 0.0138 0.0138
Schistosoma mansoni biogenic amine receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0138 0.0138
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0509 0.0792
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.3118 0.3118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi MBOAT family protein 0.0088 0.0808 0.1258
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0138 0.0215
Onchocerca volvulus 0.0029 0.0138 0.0266
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0509 0.0509
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0138 0.0138
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0138 0.0215
Loa Loa (eye worm) hypothetical protein 0.0178 0.1832 0.1832
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0374 0.0374
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0191 0.1623
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0138 0.0138
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2506 0.2506
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0138 0.0138
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0088 0.0808 0.0808
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0374 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0334 0.0334
Brugia malayi N-terminal motif family protein 0.0178 0.1832 0.2851
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.3118 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0374 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Onchocerca volvulus 0.0029 0.0138 0.0266
Mycobacterium ulcerans hypothetical protein 0.0047 0.0348 0.6846
Trypanosoma cruzi glycerol uptake protein, putative 0.0088 0.0808 1
Toxoplasma gondii hypothetical protein 0.0088 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0286 0.0285
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) PHD-finger family protein 0.002 0.004 0.0039
Onchocerca volvulus 0.0029 0.0138 0.0266
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0213 0.5696
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0191 0.1623
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0138 0.0138
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0138 0.0138
Onchocerca volvulus 0.0029 0.0138 0.0266
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0914 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0088 0.0808 0.0808
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2506 0.2506
Onchocerca volvulus 0.005 0.0374 0.1037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0509 0.6297
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus neuropeptide receptor 0.0029 0.0138 0.0138
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0138 0.0215
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0914 0.0914
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0286 0.0286
Trichomonas vaginalis transmembrane protein nessy, putative 0.0088 0.0808 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0286 0.3536
Brugia malayi larval opioid receptor 0.0029 0.0138 0.0215
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0334 0.052
Onchocerca volvulus 0.0029 0.0138 0.0266
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0138 0.0138
Leishmania major glycerol uptake protein, putative 0.0088 0.0808 1
Brugia malayi Bromodomain containing protein 0.0073 0.0636 0.0989
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0509 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0138 0.0138
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0914 0.0914
Treponema pallidum alginate O-acetylation protein (algI) 0.0088 0.0808 0.2593
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0138 0.0215
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0374 0.0374
Onchocerca volvulus 0.0029 0.0138 0.0266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Brugia malayi MBOAT family protein 0.0088 0.0808 0.1258
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0138 0.0138
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0088 0.0808 0.0808
Schistosoma mansoni hypothetical protein 0.004 0.0269 0.0269
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0138 0.0138
Brugia malayi neuropeptide F receptor 0.0029 0.0138 0.0215
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0088 0.0808 0.0808
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1042 0.8349
Echinococcus multilocularis expressed conserved protein 0.0091 0.0847 0.0847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0334 0.0334
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0138 0.0138
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0088 0.0808 0.0808
Onchocerca volvulus 0.0029 0.0138 0.0266
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0374 0.0374
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0138 0.0215
Onchocerca volvulus Huntingtin homolog 0.0123 0.1209 0.3763
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0138 0.0138
Brugia malayi hypothetical protein 0.0029 0.0138 0.0215
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0138 0.0138
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0352 0.0352
Onchocerca volvulus 0.0029 0.0138 0.0266
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.1832 0.5799
Brugia malayi hypothetical protein 0.0036 0.0223 0.0347
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0138 0.0138
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0088 0.0808 1
Loa Loa (eye worm) MBOAT family protein 0.0088 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0348 0.6846
Entamoeba histolytica hypothetical protein 0.0088 0.0808 0.8468
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0334 0.0334
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0138 0.0138
Schistosoma mansoni patched 1 0.0042 0.0286 0.0286
Echinococcus multilocularis somatostatin receptor 0.0029 0.0138 0.0138
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0138 0.0138
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0088 0.0808 0.0808
Leishmania major glycerol uptake protein, putative 0.0088 0.0808 1
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0138 0.0138
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.3118 0.3118
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0348 0.4311
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.3118 0.3118
Schistosoma mansoni amine GPCR 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0213
Plasmodium vivax hypothetical protein, conserved 0.005 0.0374 0.4631
Plasmodium falciparum thioredoxin reductase 0.0048 0.0352 0.4353
Brugia malayi G protein-coupled receptor 0.0029 0.0138 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0509 0.4318
Loa Loa (eye worm) hypothetical protein 0.0039 0.026 0.026
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0138 0.0138
Schistosoma mansoni neuropeptide receptor 0.0029 0.0138 0.0138
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0061 0.0061
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0352 0.4353
Schistosoma mansoni sterol O-acyltransferase 1 0.09 1 1
Echinococcus granulosus g protein coupled receptor 0.0029 0.0138 0.0138

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 77 nM Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of 5HT2A (receptor) ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of 5HT2C (receptor) ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of SERT ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of alpha2A adrenergic receptor ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of dopamine D2 receptor ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of dopamine D3 receptor ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of DAT ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of mu opioid receptor ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of kappa opioid receptor ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of muscarinic M3 receptor ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of NET ChEMBL. 20137933
Ki (binding) > 10 uM Inhibition of histamine H2 receptor ChEMBL. 20137933

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.