Detailed information for compound 1154165

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.525 | Formula: C28H26N3O2+
  • H donors: 0 H acceptors: 1 LogP: 4.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)/C=C/c1ccc2c(c1)c1cccc3c1c([n+]2C)c1ccccc1n3C
  • InChi: 1S/C28H26N3O2/c1-29-23-8-4-3-6-21(23)28-27-20(7-5-9-25(27)29)22-18-19(10-12-24(22)30(28)2)11-13-26(32)31-14-16-33-17-15-31/h3-13,18H,14-17H2,1-2H3/q+1/b13-11+
  • InChiKey: MSFKZNOBXNRNJW-ACCUITESSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0037 0.0412 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Brugia malayi hypothetical protein 0.0021 0.0203 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0754 0.1383
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.023 0.522
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0007 0.0028 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0412 0.9482
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0007 0.0028 0.0021
Schistosoma mansoni lipoxygenase 0.0057 0.0678 0.1241
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0049 0.0098
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0216
Schistosoma mansoni ferritin 0.0009 0.0053 0.0085
Brugia malayi beta-lactamase family protein 0.0037 0.0412 0.0828
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0041 0.0464 0.1573
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0041 0.0464 0.1573
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0041 0.0464 0.1573
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0028 0.0038
Schistosoma mansoni hypothetical protein 0.0007 0.0028 0.0038
Echinococcus multilocularis expressed protein 0.0009 0.0053 0.0046
Echinococcus granulosus snurportin 1 0.0297 0.3759 0.6946
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0053 0.0085
Echinococcus granulosus cpg binding protein 0.0032 0.0346 0.0626
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0007 0.0028 0.0488
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0041 0.0464 1
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0041 0.0464 0.1573
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0035 0.0051
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0041 0.0464 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.1547 0.1541
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0041 0.0464 0.0933
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0203 0.0409
Schistosoma mansoni cpg binding protein 0.003 0.0324 0.0586
Onchocerca volvulus 0.0041 0.0464 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0049 0.0076
Schistosoma mansoni choline o-acyltransferase 0.0041 0.0464 0.0845
Brugia malayi intermediate filament protein 0.0028 0.03 0.0604
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1547 1
Echinococcus granulosus lamin dm0 0.0028 0.03 0.0542
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0133 0.0268
Schistosoma mansoni smad 0.0008 0.0049 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1536 0.3091
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0298 0.1884
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0095
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0007 0.0028 0.0135
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0412 0.131
Loa Loa (eye worm) hypothetical protein 0.0028 0.03 0.0604
Echinococcus multilocularis Smad4 0.0008 0.0049 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0434 0.1528
Echinococcus granulosus Smad4 0.0008 0.0049 0.0076
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0007 0.0028 0.0021
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0007 0.0028 0.0488
Schistosoma mansoni lamin 0.0028 0.03 0.0542
Mycobacterium ulcerans beta-lactamase 0.0037 0.0412 0.2523
Mycobacterium leprae Probable lipase LipE 0.0037 0.0412 1
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0007 0.0028 0.0456
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0007 0.0028 0.0135
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0203 0.0632
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0007 0.0028 0.0038
Brugia malayi aldehyde dehydrogenase 0.0007 0.0028 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0051
Echinococcus multilocularis smad 0.0008 0.0049 0.0041
Brugia malayi Doublecortin family protein 0.0021 0.0203 0.0409
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0203 0.4289
Trichomonas vaginalis ferritin, putative 0.0009 0.0053 0.1072
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0028 0.0456
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0028 0.0075
Onchocerca volvulus 0.0037 0.0412 0.8804
Schistosoma mansoni ferritin light chain 0.0009 0.0053 0.0085
Schistosoma mansoni hypothetical protein 0.0297 0.3759 0.6946
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0057 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0412 0.131
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.1547 0.5522
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.03 0.0604
Brugia malayi MH2 domain containing protein 0.0008 0.0049 0.0098
Echinococcus multilocularis snurportin 1 0.0297 0.3759 0.3754
Schistosoma mansoni hypothetical protein 0.0426 0.5408 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.4969 1
Leishmania major carnitine palmitoyltransferase-like protein 0.0041 0.0464 0.1636
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0049 0.0098
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0203 0.0363
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0007 0.0028 0.0038
Loa Loa (eye worm) aldehyde dehydrogenase 0.0007 0.0028 0.0057
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0298 0.6359
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0667 0.4285
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.5408 0.5405
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0041 0.0464 0.0933
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1547 0.2851
Onchocerca volvulus 0.0041 0.0464 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Loa Loa (eye worm) hypothetical protein 0.0041 0.0464 0.0933
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0392 0.4969 1
Echinococcus multilocularis choline O acetyltransferase 0.0041 0.0464 0.0456
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0434 1
Schistosoma mansoni apoferritin-2 0.0009 0.0053 0.0085
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0008 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0434 0.2669
Echinococcus multilocularis lamin 0.0028 0.03 0.0293
Onchocerca volvulus 0.003 0.0324 0.6788
Onchocerca volvulus 0.0021 0.0203 0.4023
Echinococcus granulosus ferritin 0.0009 0.0053 0.0085
Echinococcus granulosus smad 0.0008 0.0049 0.0076
Entamoeba histolytica Ran family GTPase 0.0021 0.0203 0.4591
Loa Loa (eye worm) hypothetical protein 0.0007 0.0028 0.0057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0434 1
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0007 0.0028 0.0488
Echinococcus multilocularis ferritin 0.0009 0.0053 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0412 0.8858
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.0828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0454
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0203 0.0363
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0028 0.0038
Mycobacterium tuberculosis Conserved protein 0.0037 0.0412 0.131
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0118
Onchocerca volvulus 0.0037 0.0412 0.8804
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0434 0.0789
Echinococcus granulosus lamin 0.0028 0.03 0.0542
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0324 0.0652
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0434 0.1465
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0203 0.0632
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0464 0.1573
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1536 0.3091
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0434 0.0426
Echinococcus granulosus RUN 0.0021 0.0203 0.0363
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0007 0.0028 0.0075
Mycobacterium tuberculosis Conserved protein 0.0037 0.0412 0.131
Leishmania major hypothetical protein, conserved 0.0037 0.0412 0.1449
Trichomonas vaginalis esterase, putative 0.0037 0.0412 0.9482
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Schistosoma mansoni inositol monophosphatase 0.0038 0.0434 0.0789
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0412 0.9482
Brugia malayi kap beta 3 protein 0.0005 0.0008 0.0015
Echinococcus multilocularis musashi 0.0028 0.03 0.0293
Schistosoma mansoni smad1 5 8 and 0.0008 0.0049 0.0076
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0041 0.0464 0.1573
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0027 0.0454
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0007 0.0028 0.0456
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0678 0.0671
Echinococcus granulosus expressed protein 0.0009 0.0053 0.0085
Schistosoma mansoni cpg binding protein 0.0032 0.0346 0.0626
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0049 0.0076
Loa Loa (eye worm) beta-lactamase 0.0037 0.0412 0.0828
Loa Loa (eye worm) inositol-1 0.0038 0.0434 0.0873
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0464 0.1573
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0007 0.0028 0.0135
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0053 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1547 1
Schistosoma mansoni lipoxygenase 0.0021 0.0203 0.0363
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0203 0.0363
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3759 0.7564
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0053 0.0164
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0041 0.0464 0.1573
Brugia malayi hypothetical protein 0.0021 0.0203 0.0409
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0114 0.0197
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0007 0.0028 0.0488
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0222 0.2796 0.279
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0412 0.0828
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0203 0.4842
Echinococcus granulosus importin subunit beta 1 0.0028 0.0298 0.0537
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0007 0.0028 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0464 0.1573
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.0828
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0049 0.0041
Echinococcus multilocularis cpg binding protein 0.0032 0.0346 0.0338
Schistosoma mansoni polycystin 1-related 0.0021 0.0203 0.0363
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0412 0.131
Brugia malayi Aldehyde dehydrogenase protein 4 0.0007 0.0028 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0464 0.1573
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0035 0.0051
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0007 0.0028 0.0456
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0041 0.0464 0.0933
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0028 0.0075
Schistosoma mansoni inositol monophosphatase 0.0038 0.0434 0.0789
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0203 0.4849
Mycobacterium ulcerans lipase LipD 0.0037 0.0412 0.2523
Schistosoma mansoni ferritin 0.0009 0.0053 0.0085
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0412 0.2523
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0434 1
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0007 0.0028 0.0021
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0412 0.131
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0434 1
Schistosoma mansoni ferritin light chain 0.0009 0.0053 0.0085
Onchocerca volvulus 0.0041 0.0464 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0053 0.0614
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0412 0.131
Onchocerca volvulus 0.0028 0.03 0.625
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0203 0.0196
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0053 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0412 0.1385
Loa Loa (eye worm) hypothetical protein 0.0007 0.0028 0.0057
Leishmania major carnitine/choline acetyltransferase, putative 0.0041 0.0464 0.1636
Schistosoma mansoni ran 0.0021 0.0203 0.0362
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0412 0.131
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0412 1
Onchocerca volvulus 0.0028 0.03 0.625
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0007 0.0028 0.0057
Schistosoma mansoni ran 0.0021 0.0203 0.0362
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0007 0.0028 0.0021
Brugia malayi MH1 domain containing protein 0.0008 0.0049 0.0098
Loa Loa (eye worm) intermediate filament protein 0.0028 0.03 0.0604
Echinococcus granulosus dnaJ subfamily B 0.0426 0.5408 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0229
Schistosoma mansoni Smad4 0.0008 0.0049 0.0076
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.1547 0.2851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0454
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0053 0.065
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0007 0.0028 0.0488
Onchocerca volvulus 0.0041 0.0464 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.1547 0.5192
Brugia malayi Choline O-acetyltransferase 0.0041 0.0464 0.0933
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0382 0.1209
Schistosoma mansoni rab6-interacting 0.0021 0.0203 0.0363
Schistosoma mansoni apoferritin-2 0.0009 0.0053 0.0085
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2954 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1547 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0049 0.0076
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.1547 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0035 0.0028
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0041 0.0464 0.0845
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0028 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0412 0.1385
Leishmania major GTP-binding protein, putative 0.0021 0.0203 0.0702
Schistosoma mansoni rab6-interacting 0.0021 0.0203 0.0363
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0203 0.1271
Loa Loa (eye worm) choline O-acetyltransferase 0.0041 0.0464 0.0933
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0409
Loa Loa (eye worm) hypothetical protein 0.0028 0.0298 0.0599
Echinococcus granulosus intermediate filament protein 0.0028 0.03 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1547 0.2851
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0203 0.0196
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0007 0.0028 0.0038
Onchocerca volvulus 0.0037 0.0412 0.8804
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Mycobacterium ulcerans hypothetical protein 0.0037 0.0412 0.2523
Trichomonas vaginalis helicase, putative 0.0007 0.0027 0.0454
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0133 0.0268
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0028 0.0038
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0007 0.0028 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0035 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0454
Onchocerca volvulus 0.0021 0.0203 0.4023
Plasmodium vivax importin-beta 2, putative 0.0028 0.0298 0.7179
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0412 0.2523
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.03 0.0604
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0464 0.1573
Schistosoma mansoni intermediate filament proteins 0.0028 0.03 0.0542
Brugia malayi Inositol-1 0.0038 0.0434 0.0873
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.0828
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0008 0.0015
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0049 0.0041
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0203 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0412 0.9482
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0041 0.0464 1
Schistosoma mansoni ferritin 0.0009 0.0053 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0409
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0203 0.6755
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.023 0.522
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0028 0.0075
Echinococcus granulosus choline O acetyltransferase 0.0041 0.0464 0.0845
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0035 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.0828
Trichomonas vaginalis ran, putative 0.0021 0.0203 0.4591
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0007 0.0028 0.0456
Entamoeba histolytica hypothetical protein 0.0023 0.023 0.522
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0203 0.6744
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0222 0.2796 1
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0041 0.0464 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Brugia malayi Smad1 0.0008 0.0049 0.0098
Brugia malayi beta-lactamase 0.0037 0.0412 0.0828
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0678 0.1241
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0412 0.0748
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0222 0.2796 1
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0028 0.0075
Brugia malayi MH2 domain containing protein 0.0124 0.1536 0.3091
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0412 0.9482
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0007 0.0028 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0203 0.0196
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0222 0.2796 0.5163
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.0828
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.023 0.0729
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0007 0.0028 0.0021
Schistosoma mansoni importin beta-1 0.0028 0.0298 0.0537
Brugia malayi Choline O-acetyltransferase 0.0041 0.0464 0.0933
Brugia malayi beta-lactamase family protein 0.0037 0.0412 0.0828
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0027 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0454
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0412 1
Schistosoma mansoni choline o-acyltransferase 0.0041 0.0464 0.0845
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0412 0.0748
Brugia malayi Importin beta-1 subunit 0.0028 0.0298 0.0599
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0007 0.0028 0.0038
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0298 0.029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0412 0.0404
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0203 0.0409
Toxoplasma gondii ABC1 family protein 0.0037 0.0412 0.2624
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0222 0.2796 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0049 0.0076
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0053 0.0085
Loa Loa (eye worm) hypothetical protein 0.0028 0.0294 0.0591
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0298 0.6359
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0434 0.9342
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0203 0.0409
Schistosoma mansoni cpg binding protein 0.0032 0.0346 0.0626
Plasmodium falciparum importin beta, putative 0.0028 0.0298 1
Echinococcus multilocularis RUN 0.0021 0.0203 0.0196
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0434 0.1465
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0114 0.0106
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0041 0.0464 0.0456
Schistosoma mansoni loxhd1 0.0021 0.0203 0.0363
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0203 0.0362
Schistosoma mansoni ferritin 0.0009 0.0053 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0412 0.9482
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0027 0.0454
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0412 0.0748
Loa Loa (eye worm) Smad1 0.0008 0.0049 0.0098
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0007 0.0028 0.0057
Brugia malayi CXXC zinc finger family protein 0.003 0.0324 0.0652
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0412 0.0828
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0041 0.0464 0.0933
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.0828
Brugia malayi RNA, U transporter 1 0.0079 0.0957 0.1926
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0028 0.0038
Schistosoma mansoni hypothetical protein 0.0021 0.0203 0.0363
Schistosoma mansoni lamin 0.0028 0.03 0.0542
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0464 1
Brugia malayi MH2 domain containing protein 0.0008 0.0049 0.0098
Trichomonas vaginalis importin beta-1, putative 0.0023 0.023 0.522
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0434 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0382 0.9226
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0203 0.0196
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0434 0.2768
Brugia malayi MH1 domain containing protein 0.0008 0.0049 0.0098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0412 0.131
Echinococcus multilocularis lamin dm0 0.0028 0.03 0.0293
Leishmania major importin beta-1 subunit, putative 0.0023 0.023 0.0798
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0007 0.0028 0.0038
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0049 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0027 0.0454

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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