Detailed information for compound 1188393

Basic information

Technical information
  • TDR Targets ID: 1188393
  • Name: 3-ethyl-N-[[5-(2-fluorophenyl)-1,3,4-oxadiazo l-2-yl]-phenylmethyl]aniline
  • MW: 373.423 | Formula: C23H20FN3O
  • H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1)NC(c1nnc(o1)c1ccccc1F)c1ccccc1
  • InChi: 1S/C23H20FN3O/c1-2-16-9-8-12-18(15-16)25-21(17-10-4-3-5-11-17)23-27-26-22(28-23)19-13-6-7-14-20(19)24/h3-15,21,25H,2H2,1H3
  • InChiKey: CXXNLUJZWPNVAB-UHFFFAOYSA-N  


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Synonyms

  • 3-ethyl-N-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]-phenyl-methyl]aniline
  • (3-ethylphenyl)-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]-phenyl-methyl]amine
  • C301-6313
  • NCGC00107362-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Echinococcus multilocularis mothers against decapentaplegic 5 0.0065 0.0228 0.0216
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0038 0.1358
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0018 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0046 0.0146 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0027 0.0906
Schistosoma mansoni cpg binding protein 0.0084 0.0307 0.054
Schistosoma mansoni tar DNA-binding protein 0.0266 0.1087 0.1917
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0031 0.0147
Loa Loa (eye worm) glutathione reductase 0.0046 0.0146 0.0332
Plasmodium vivax glutathione reductase, putative 0.0046 0.0146 1
Schistosoma mansoni smad 0.0029 0.0074 0.0129
Loa Loa (eye worm) ctsf protein 0.0016 0.0019 0.0017
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0136 0.0239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0172 0.0775
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.0713 0.1256
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0072 0.043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0031 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0506 0.2113 1
Echinococcus granulosus Smad4 0.0065 0.0228 0.0216
Echinococcus multilocularis dna polymerase eta 0.0019 0.0031 0.0019
Loa Loa (eye worm) MH1 domain-containing protein 0.0065 0.0228 0.0536
Echinococcus multilocularis smad 0.0065 0.0228 0.0216
Echinococcus multilocularis musashi 0.0159 0.063 0.0618
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0023 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0031 0.0805
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0023 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0013 0.0059
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0059 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0018 0.001
Schistosoma mansoni smad1 5 8 and 0.0065 0.0228 0.04
Brugia malayi MH1 domain containing protein 0.0065 0.0228 0.0536
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0018 0.0029
Leishmania major cytochrome p450-like protein 0.0015 0.0016 0.0147
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0098 0.3723
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.106
Trichomonas vaginalis glucosylceramidase, putative 0.0506 0.2113 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0023 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.006 0.0285
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0039 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0019 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0172 0.0775
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0243 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0023 0.0025
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0397 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.0239
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0447 0.2136
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0018 0.0232
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0172 0.0775
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0023 0.0025
Onchocerca volvulus 0.0159 0.063 0.4355
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0397 0.1888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0136 0.0646
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0023 0.001
Toxoplasma gondii dgat2l1-prov protein 0.0046 0.0146 0.2104
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0136 0.5369
Brugia malayi hypothetical protein 0.0016 0.0019 0.0016
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0023 0.0038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0085 0.0314 0.0751
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0018 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0023 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0031 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0072 0.0149
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0098 0.0465
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Echinococcus granulosus intermediate filament protein 0.0159 0.063 0.0618
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.0713 0.0702
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0023 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0072 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Mycobacterium ulcerans lipase LipD 0.0036 0.0105 0.0445
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0016 0.0008
Schistosoma mansoni cpg binding protein 0.0088 0.0328 0.0576
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0105 0.6825
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0023 0.0038
Echinococcus granulosus dna polymerase eta 0.0019 0.0031 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0023 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0023 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0177 0.0708 0.1247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0023 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0179 0.0713 0.1743
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0046 0.0146 0.59
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0098 0.0465
Brugia malayi diacylglycerol acyltransferase family protein 0.0046 0.0146 0.0332
Leishmania major hypothetical protein, conserved 0.0036 0.0105 0.4016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0231
Echinococcus granulosus geminin 0.0334 0.1378 0.1368
Brugia malayi beta-lactamase 0.0036 0.0105 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Brugia malayi TAR-binding protein 0.0266 0.1087 0.2675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0231
Schistosoma mansoni microtubule-associated protein tau 0.1338 0.5668 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Onchocerca volvulus 0.0344 0.1421 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0023 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0249 0.0237
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0023 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.331 0.3302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0031 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0266 0.1087 0.1917
Loa Loa (eye worm) hypothetical protein 0.0159 0.063 0.1536
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0215 0.8758
Schistosoma mansoni DNA polymerase eta 0.0019 0.0031 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0057 0.1922
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0031 0.0805
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0041 0.1837
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0031 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Schistosoma mansoni tar DNA-binding protein 0.0266 0.1087 0.1917
Onchocerca volvulus 0.0017 0.0023 0.0022
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0105 0.0093
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0215 0.8758
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0215 0.8758
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0146 0.0134
Brugia malayi nuclear hormone receptor 0.0017 0.0023 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.0713 0.0702
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0039 0.0026
Loa Loa (eye worm) transcription factor SMAD2 0.0955 0.4032 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0075 0.0355
Brugia malayi steroid hormone receptor 0.0017 0.0023 0.0025
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0098 0.3723
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0231
Schistosoma mansoni smad 0.0065 0.0228 0.04
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0018 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0023 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0072 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0585 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Loa Loa (eye worm) intermediate filament protein 0.0159 0.063 0.1536
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0023 0.001
Brugia malayi cytoplasmic intermediate filament protein 0.0085 0.0314 0.0751
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0031 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0023 0.0038
Echinococcus granulosus cpg binding protein 0.0088 0.0328 0.0316
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0023 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0243 1
Brugia malayi RNA recognition motif domain containing protein 0.0266 0.1087 0.2675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0223 0.0903 0.2214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0136 0.0646
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Entamoeba histolytica hypothetical protein 0.007 0.0249 0.1865
Brugia malayi MH1 domain containing protein 0.0036 0.0104 0.0227
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0136 0.0124
Brugia malayi latrophilin 2 splice variant baaae 0.0482 0.2008 0.4965
Schistosoma mansoni tar DNA-binding protein 0.0266 0.1087 0.1917
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0805
Onchocerca volvulus 0.0084 0.0307 0.2054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Mycobacterium tuberculosis Conserved protein 0.0036 0.0105 0.0435
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0805
Onchocerca volvulus Glucosylceramidase homolog 0.0332 0.137 0.9633
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0077 0.0278 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0023 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0105 0.0498
Entamoeba histolytica hypothetical protein 0.007 0.0249 0.1865
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.1249 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.106
Brugia malayi Cytochrome P450 family protein 0.0015 0.0016 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0013 0.0059
Echinococcus multilocularis tar DNA binding protein 0.0266 0.1087 0.1076
Echinococcus granulosus mothers against decapentaplegic 2 0.0029 0.0074 0.0062
Toxoplasma gondii aldehyde dehydrogenase 0.0052 0.0172 0.2524
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0105 0.4183
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Echinococcus granulosus transcription factor Dp 1 0.004 0.012 0.0107
Loa Loa (eye worm) hypothetical protein 0.0074 0.0266 0.063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0018 0.0503
Leishmania major DNA polymerase eta, putative 0.0019 0.0031 0.0805
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Mycobacterium ulcerans hypothetical protein 0.0029 0.0072 0.0281
Echinococcus multilocularis cpg binding protein 0.0088 0.0328 0.0316
Brugia malayi MH2 domain containing protein 0.0029 0.0074 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0795 0.3348 0.3339
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0146 0.5777
Loa Loa (eye worm) MH1 domain-containing protein 0.0029 0.0074 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0061 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0105 0.0498
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0023 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0031 0.0146
Echinococcus multilocularis cysteine protease 0.0016 0.0019 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0046
Entamoeba histolytica hypothetical protein 0.007 0.0249 0.1865
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0105 0.0435
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0018 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0136 0.5498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0013 0.0059
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0506 0.2113 0.5227
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0019 0.0032
Leishmania major cathepsin L-like protease 0.0016 0.0019 0.0301
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0023 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Leishmania major cathepsin L-like protease 0.0062 0.0215 0.8758
Echinococcus multilocularis lamin dm0 0.0159 0.063 0.0618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Plasmodium vivax vivapain-2 0.0016 0.0019 0.0125
Brugia malayi CXXC zinc finger family protein 0.0084 0.0307 0.0733
Schistosoma mansoni smad1 5 8 and 0.0065 0.0228 0.04
Schistosoma mansoni hypothetical protein 0.007 0.0249 0.0437
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0072 0.259
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0136 0.5369
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0019 0.0007
Onchocerca volvulus 0.0036 0.0105 0.0612
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0057 0.1922
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0072 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0023 0.0025
Mycobacterium ulcerans hypothetical protein 0.0036 0.0105 0.0445
Loa Loa (eye worm) fibroinase 0.0016 0.0019 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Loa Loa (eye worm) hypothetical protein 0.0344 0.1421 0.3504
Giardia lamblia DINP protein human, muc B family 0.0019 0.0031 0.0107
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0243 0.0231
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0243 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0019 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0072 0.0281
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0065 0.0228 0.0216
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0019 0.0301
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0072 0.0281
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0041 0.1837
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0105 0.0231
Brugia malayi hypothetical protein 0.0136 0.0532 0.1292
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0089 0.1163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0092
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0192 0.7763
Toxoplasma gondii thioredoxin reductase 0.0046 0.0146 0.2102
Brugia malayi beta-lactamase family protein 0.0036 0.0105 0.0231
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0019 0.0125
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0057 0.0641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0057 0.2146
Mycobacterium tuberculosis Conserved protein 0.0036 0.0105 0.0435
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0057 0.3048
Leishmania major cathepsin L-like protease 0.0016 0.0019 0.0301
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0072 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0031 0.0046
Echinococcus multilocularis lamin 0.0159 0.063 0.0618
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0215 0.8758
Schistosoma mansoni lamin 0.0159 0.063 0.1109
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0041 0.0127
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0013 0.002
Mycobacterium tuberculosis Probable reductase 0.0105 0.0397 0.1888
Trypanosoma brucei unspecified product 0.0019 0.0031 0.106
Echinococcus multilocularis mothers against decapentaplegic 2 0.0029 0.0074 0.0062
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0019 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0018 0.0503
Brugia malayi Smad1 0.0065 0.0228 0.0536
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0249 0.0437
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0105 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0023 0.0025
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0031 0.106
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1446 0.6842
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.0903 0.0891
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0031 0.0053
Loa Loa (eye worm) beta-lactamase 0.0036 0.0105 0.0231
Echinococcus multilocularis cysteine protease 0.0016 0.0019 0.0007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0447 0.2136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.0239
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.1249 1
Schistosoma mansoni hypothetical protein 0.0334 0.1378 0.243
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0397 0.1888
Echinococcus granulosus lamin dm0 0.0159 0.063 0.0618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Schistosoma mansoni hypothetical protein 0.0334 0.1378 0.243
Plasmodium falciparum thioredoxin reductase 0.0046 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0532 0.1292
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0041 0.0117
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0019
Echinococcus multilocularis GPCR, family 2 0.0223 0.0903 0.0891
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0105 0.0093
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0105 0.0643
Onchocerca volvulus 0.0046 0.0146 0.0903
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0105 0.0435
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0136 0.0952
Leishmania major cathepsin L-like protease 0.0016 0.0019 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0098 0.0465
Echinococcus granulosus dna polymerase kappa 0.0019 0.0031 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.1249 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0023 0.001
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0029 0.0074 0.0391
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0019 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0105 0.0498
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0136 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0092
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0243 0.0427
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.106
Trypanosoma brucei trypanothione reductase 0.0046 0.0146 0.5894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0076
Brugia malayi MH1 domain containing protein 0.0065 0.0228 0.0536
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0018 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0136 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0072 0.0149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0031 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0243 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0146 0.0332
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0072 0.259
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0156 0.0617 0.1505
Echinococcus granulosus smad 0.0065 0.0228 0.0216
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0023 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Schistosoma mansoni hypothetical protein 0.0223 0.0903 0.1591
Brugia malayi hypothetical protein 0.007 0.0249 0.0588
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0105 0.0498
Echinococcus granulosus tar DNA binding protein 0.0266 0.1087 0.1076
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0052 0.0172 0.0159
Giardia lamblia GTOR 0.0044 0.0136 0.0963
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0805
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.0713 0.0702
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.0713 0.1256
Schistosoma mansoni hypothetical protein 0.0795 0.3348 0.5905
Trichomonas vaginalis glucosylceramidase, putative 0.0506 0.2113 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.0903 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus granulosus TGF beta signal transducer SmadC 0.0065 0.0228 0.0216
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0447 0.7309
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0018 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0172 0.0301
Mycobacterium leprae Probable lipase LipE 0.0036 0.0105 0.0643
Leishmania major diacylglycerol acyltransferase, putative 0.0046 0.0146 0.5783
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0065 0.0228 0.04
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0105 0.0435
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Echinococcus granulosus lamin 0.0159 0.063 0.0618
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0059 0.0116
Schistosoma mansoni cpg binding protein 0.0088 0.0328 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.024
Echinococcus multilocularis microtubule associated protein 2 0.1338 0.5668 0.5663
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0223 0.0903 0.0891
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0039 0.0026
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0013 0.0278
Loa Loa (eye worm) Smad1 0.0065 0.0228 0.0536
Onchocerca volvulus 0.0029 0.0072 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Brugia malayi ecdysteroid receptor 0.0017 0.0023 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0018 0.5
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0136 0.5498
Toxoplasma gondii histone lysine methyltransferase SET1 0.0158 0.0627 1
Loa Loa (eye worm) nuclear factor I 0.0036 0.0104 0.0227
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0018 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0486 0.2026 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Loa Loa (eye worm) hypothetical protein 0.0074 0.0266 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0061 0.0291
Leishmania major trypanothione reductase 0.0046 0.0146 0.5777
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0061 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0105 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0805
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0397 0.6336
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0052 0.0172 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0105 0.0445
Brugia malayi glutathione reductase 0.0046 0.0146 0.0332
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0023 0.0038
Leishmania major cathepsin L-like protease 0.0062 0.0215 0.8758
Echinococcus multilocularis dnaJ subfamily B 0.0795 0.3348 0.3339
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0158 0.6304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0482 0.2008 0.4965
Leishmania major cathepsin L-like protease 0.0016 0.0019 0.0301
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0019 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0105 0.0498
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0023 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0016 0.0421
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0023 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0023 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0046 0.0146 0.5783
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0023 0.0025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0023 0.001
Onchocerca volvulus 0.0036 0.0105 0.0612
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0019 0.0125
Leishmania major cathepsin L-like protease 0.0062 0.0215 0.8758
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0019 0.0007
Brugia malayi Cytochrome P450 family protein 0.0025 0.0059 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0061 0.0048
Brugia malayi MH1 domain containing protein 0.0036 0.0104 0.0227
Onchocerca volvulus 0.0036 0.0105 0.0612
Leishmania major hypothetical protein, conserved 0.0025 0.0057 0.1922
Brugia malayi Cytochrome P450 family protein 0.0015 0.0016 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0149
Schistosoma mansoni Smad4 0.0029 0.0074 0.0129
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0447 0.2136
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0179 0.0713 0.1743
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.0713 0.0702
Onchocerca volvulus 0.0159 0.063 0.4355
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0092
Schistosoma mansoni cellular tumor antigen P53 0.0344 0.1421 0.2505
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0019 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0023 0.0025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0052 0.0172 0.0766
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0018 0.0232
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0023 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0071 0.0336
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0057 0.3048
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0017
Brugia malayi RNA binding protein 0.0266 0.1087 0.2675
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0057 0.3048
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0019 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0023 0.001
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0018 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0105 0.4016
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0136 0.0308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0072 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus granulosus microtubule associated protein 2 0.1338 0.5668 0.5663
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0018 0.0232
Brugia malayi Latrophilin receptor protein 2 0.0223 0.0903 0.2214
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0031 0.0146
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0031 0.0147
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0039 0.0026
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0013 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0013 0.0059
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0046 0.0146 0.5783
Schistosoma mansoni Smad4 0.0065 0.0228 0.04
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0149
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0046 0.0146 0.0332
Brugia malayi Calcitonin receptor-like protein seb-1 0.0704 0.2961 0.7335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0036 0.0092
Toxoplasma gondii ABC1 family protein 0.0036 0.0105 0.1435
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0023 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0109 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0506 0.2113 0.5227
Brugia malayi intermediate filament protein 0.0159 0.063 0.1536
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0136 0.0308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0023 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0704 0.2961 0.7335
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0023 0.0025
Schistosoma mansoni intermediate filament proteins 0.0159 0.063 0.1109
Loa Loa (eye worm) STAT protein 0.0128 0.0496 0.1203
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0072 0.259
Schistosoma mansoni Smad4 0.0029 0.0074 0.0129
Loa Loa (eye worm) cysteine protease 0.0016 0.0019 0.0017
Mycobacterium ulcerans beta-lactamase 0.0036 0.0105 0.0445
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0098 0.3897
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0016 0.0008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0052 0.0172 0.689
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0023 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0506 0.2113 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0942 0.4603
Schistosoma mansoni hypothetical protein 0.0482 0.2008 0.3541
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0231
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0019 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0105 0.4016
Brugia malayi nuclear receptor NHR-88 0.0017 0.0023 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0018 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0249 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0072
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0136 0.5369
Leishmania major cathepsin L-like protease 0.0016 0.0019 0.0301
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1446 0.6842
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.1249 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0029 0.0074 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Trichomonas vaginalis helicase, putative 0.0019 0.0031 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0018 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0023 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0146 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0077 0.0278 0.0266
Plasmodium vivax vivapain-2 0.0016 0.0019 0.0125
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0031 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.0713 0.1256
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0243 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0061 0.0291
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0172 0.0301
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0397 0.1888
Brugia malayi MH2 domain containing protein 0.0955 0.4032 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0146 0.0638
Echinococcus granulosus Solute carrier family 22 5 0.1077 0.4551 0.4545
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0031 0.0146
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0031 0.0066
Echinococcus multilocularis geminin 0.0334 0.1378 0.1368
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0016 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0039 0.0026
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0016 0.0147
Loa Loa (eye worm) RNA binding protein 0.0266 0.1087 0.2675
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0072 0.0281
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0585 0.283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0089 0.042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0018 0.0232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0031 0.0146
Toxoplasma gondii cathepsin CPL 0.0016 0.0019 0.0026
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0061 0.0119
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0072 0.0281
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0023 0.0038
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0266 0.1087 0.2675
Brugia malayi Intermediate filament tail domain containing protein 0.0159 0.063 0.1536
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0105 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0266 0.1087 0.1917
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0031 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0506 0.2113 1
Brugia malayi beta-lactamase family protein 0.0036 0.0105 0.0231
Schistosoma mansoni lamin 0.0159 0.063 0.1109
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0486 0.2026 1
Schistosoma mansoni smad1 5 8 and 0.0065 0.0228 0.04
Loa Loa (eye worm) MH2 domain-containing protein 0.0029 0.0074 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0019 0.0092
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0072 0.0281
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0031 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0023 0.0038
Trichomonas vaginalis esterase, putative 0.0036 0.0105 0.0498
Echinococcus granulosus cathepsin l1 0.0016 0.0019 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0018 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.006 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0051 0.024
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0146 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0013 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0023 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0031 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0955 0.4032 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0223 0.0903 0.0891
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0136 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0023 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0023 0.001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0019 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0307 0.0733
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0704 0.2961 0.7335
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0023 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0023 0.0025
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0243 0.0574
Onchocerca volvulus 0.0019 0.0031 0.0081
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0019 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1249 0.5911
Loa Loa (eye worm) hypothetical protein 0.0077 0.0278 0.0661
Loa Loa (eye worm) TAR-binding protein 0.0266 0.1087 0.2675
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0105 0.0435
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0023 0.001
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0243 0.1821
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0023 0.0025
Brugia malayi MH2 domain containing protein 0.0065 0.0228 0.0536
Brugia malayi hypothetical protein 0.0025 0.0057 0.011
Schistosoma mansoni coup transcription factor 0.0017 0.0023 0.0038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0072 0.043
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0016 0.0147
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0041 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0029 0.0074 0.0154
Echinococcus granulosus GPCR family 2 0.0223 0.0903 0.0891
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0105 0.0445
Echinococcus multilocularis mothers against decapentaplegic 6 0.0029 0.0074 0.0062
Loa Loa (eye worm) hypothetical protein 0.0704 0.2961 0.7335
Trichomonas vaginalis glucosylceramidase, putative 0.0506 0.2113 1
Schistosoma mansoni hypothetical protein 0.0223 0.0903 0.1591
Schistosoma mansoni hypothetical protein 0.0223 0.0903 0.1591
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0105 0.0184
Brugia malayi STAT protein, DNA binding domain containing protein 0.0128 0.0496 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0098 0.0465
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0072 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0215 0.8793
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.137 0.648
Loa Loa (eye worm) hypothetical protein 0.0223 0.0903 0.2214
Entamoeba histolytica hypothetical protein 0.007 0.0249 0.1865
Loa Loa (eye worm) latrophilin receptor protein 2 0.0223 0.0903 0.2214
Echinococcus granulosus mothers against decapentaplegic 5 0.0065 0.0228 0.0216
Leishmania major DNA polymerase kappa, putative 0.0019 0.0031 0.0805
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0136 0.5369
Onchocerca volvulus 0.0136 0.0532 0.3655
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0105 0.0435
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0243 1
Brugia malayi MH2 domain containing protein 0.0065 0.0228 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0023 0.0025
Echinococcus multilocularis Smad4 0.0065 0.0228 0.0216
Mycobacterium tuberculosis Conserved protein 0.0036 0.0105 0.0435
Plasmodium falciparum glutathione reductase 0.0046 0.0146 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 0.0092
Brugia malayi Thioredoxin reductase 0.0046 0.0146 0.0332
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0585 0.2823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0098 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0105 0.0435
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0397 0.1888
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0023 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 0.0092
Echinococcus multilocularis transcription factor Dp 1 0.004 0.012 0.0107
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0018 0.0503
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0159 0.063 0.1536
Loa Loa (eye worm) MH2 domain-containing protein 0.0065 0.0228 0.0536
Schistosoma mansoni hypothetical protein 0.0223 0.0903 0.1591

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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