Detailed information for compound 1202026

Basic information

Technical information
  • TDR Targets ID: 1202026
  • Name: 2-(1,3-benzodioxol-5-ylmethyl)-N-cyclohexyl-3 -oxo-1H-isoindole-1-carboxamide
  • MW: 392.448 | Formula: C23H24N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1N(Cc2ccc3c(c2)OCO3)C(=O)c2c1cccc2)NC1CCCCC1
  • InChi: 1S/C23H24N2O4/c26-22(24-16-6-2-1-3-7-16)21-17-8-4-5-9-18(17)23(27)25(21)13-15-10-11-19-20(12-15)29-14-28-19/h4-5,8-12,16,21H,1-3,6-7,13-14H2,(H,24,26)
  • InChiKey: SIJHCFMTFGFHOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1,3-benzodioxol-5-ylmethyl)-N-cyclohexyl-3-oxo-isoindoline-1-carboxamide
  • 2-(1,3-benzodioxol-5-ylmethyl)-N-cyclohexyl-3-oxo-1-isoindolinecarboxamide
  • 2-(1,3-benzodioxol-5-ylmethyl)-N-cyclohexyl-3-keto-isoindoline-1-carboxamide
  • MLS000674061
  • SMR000311339
  • Oprea1_231903
  • AO-476/14976001
  • 2-(1,3-benzodioxol-5-ylmethyl)-N-cyclohexyl-3-oxoisoindoline-1-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax serine/threonine protein kinase 6, putative 0.015 0.0995 0.8942
Schistosoma mansoni unc-13 (munc13) 0.0041 0.0018 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0224 0.0334
Echinococcus granulosus titin 0.0042 0.0031 0.0026
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0165 0.1128 0.1362
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0079 0.0357 0.1237
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.1483 0.2212
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0046 0.0066 0.0166
Giardia lamblia Kinase, CK1 Casein kinase 0.0064 0.0224 0.0711
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0163 0.111 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0294 0.2283 0.2477
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0294 0.2283 0.8324
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0205 0.1483 0.1792
Trichomonas vaginalis CMGC family protein kinase 0.0131 0.0821 0.33
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0046 0.0066 0.0166
Schistosoma mansoni protein kinase 0.0082 0.0381 0.0568
Echinococcus granulosus insulin receptor 0.05 0.4126 0.4123
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0246 0.0368
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0334 0.129
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0149 0.0988 0.1192
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0166 0.1136 0.4101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0165 0.1128 0.1362
Loa Loa (eye worm) glutaminase 2 0.0312 0.2446 0.2654
Loa Loa (eye worm) hypothetical protein 0.0071 0.0283 0.0307
Giardia lamblia Kinase, CMGC GSK 0.0131 0.0821 0.3406
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0082 0.0381 0.0376
Schistosoma mansoni protein kinase 0.0235 0.1758 0.2622
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0234 0.1749 0.2115
Trypanosoma cruzi casein kinase, putative 0.0064 0.0224 0.0746
Brugia malayi Protein kinase domain containing protein 0.007 0.0276 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0541 0.0808
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0119 0.0719 0.078
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0203 0.022
Brugia malayi RhoGAP domain containing protein 0.0039 0.0005 0.0005
Echinococcus multilocularis casein kinase I alpha 0.0064 0.0224 0.0265
Brugia malayi Protein kinase domain containing protein 0.0119 0.0719 0.078
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0995 0.1484
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0082 0.0381 0.0456
Brugia malayi glutaminase DH11.1 0.0312 0.2446 0.2654
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0245 0.1842 0.2227
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0205 0.1483 0.2856
Schistosoma mansoni glutaminase 0.0312 0.2446 0.3648
Onchocerca volvulus 0.007 0.0276 0.0511
Loa Loa (eye worm) hypothetical protein 0.009 0.0457 0.0496
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Loa Loa (eye worm) hypothetical protein 0.0057 0.0161 0.0175
Echinococcus multilocularis raf serine:threonine protein kinase 0.0075 0.0325 0.0388
Echinococcus multilocularis dnaJ subfamily B 0.0467 0.3832 0.4641
Loa Loa (eye worm) AGC/PKA protein kinase 0.0066 0.0246 0.0267
Loa Loa (eye worm) hypothetical protein 0.0088 0.0435 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0325 0.0484
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0437 0.3562 0.4314
Echinococcus granulosus myotubularin protein 13 0.0046 0.0062 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1302 0.1942
Loa Loa (eye worm) hypothetical protein 0.0308 0.2406 0.261
Plasmodium falciparum serine/threonine protein kinase, putative 0.015 0.0995 0.8898
Echinococcus granulosus Immunoglobulin 0.0087 0.0432 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0119 0.0178
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.0526 0.2268
Plasmodium falciparum calcium-dependent protein kinase 1 0.0046 0.0067 0.0005
Echinococcus multilocularis Immunoglobulin 0.0087 0.0432 0.0518
Leishmania major protein kinase, putative 0.0056 0.0153 0.0484
Giardia lamblia Kinase, CMGC GSK 0.0131 0.0821 0.3406
Echinococcus multilocularis death associated protein kinase 1 0.0961 0.8251 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Echinococcus multilocularis hypothetical protein 0.0071 0.0283 0.0337
Schistosoma mansoni protein kinase 0.0056 0.0157 0.0234
Echinococcus granulosus titin 0.0042 0.0031 0.0026
Echinococcus multilocularis cyclin dependent kinase 1 0.0119 0.0719 0.0866
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0123 0.0755 0.27
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Schistosoma mansoni protein kinase 0.0098 0.0526 0.0785
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0066 0.0246 0.1727
Mycobacterium ulcerans glutaminase 0.0312 0.2446 1
Entamoeba histolytica protein kinase, putative 0.0054 0.0138 0.0581
Giardia lamblia Aurora kinase 0.015 0.0995 0.4189
Leishmania major protein kinase, putative 0.015 0.0995 0.3583
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0041 0.0018 0.0016
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0074 0.031 0.037
Entamoeba histolytica protein kinase, putative 0.0046 0.0067 0.0272
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0345 0.2739 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Echinococcus granulosus peroxidasin 0.0041 0.0016 0.0011
Loa Loa (eye worm) AUR protein kinase 0.015 0.0995 0.1079
Brugia malayi casein kinase I 0.0064 0.0224 0.0243
Loa Loa (eye worm) CAMK protein kinase 0.0042 0.0031 0.0033
Schistosoma mansoni ephrin receptor 0.011 0.0632 0.0943
Entamoeba histolytica hypothetical protein 0.0039 0.0005 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Brugia malayi Temporarily assigned gene name protein 59 0.0149 0.0983 0.1067
Trichomonas vaginalis AGC family protein kinase 0.015 0.0995 0.4016
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0166 0.1136 0.4101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0119 0.0114
Schistosoma mansoni unc-13 (munc13) 0.0041 0.0018 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0353 0.2805 0.3044
Onchocerca volvulus 0.005 0.01 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0038 0.0041
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0079 0.0357 0.1237
Brugia malayi protein kinase C II. 0.0189 0.134 0.1454
Trypanosoma brucei protein kinase, putative 0.0131 0.0821 0.2944
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.1749 0.2609
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.1317 0.1591
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0205 0.1483 0.1479
Trypanosoma cruzi polo-like protein kinase, putative 0.0294 0.2283 0.8324
Entamoeba histolytica protein kinase, putative 0.0131 0.0821 0.3549
Brugia malayi protein-tyrosine kinase 0.0137 0.0881 0.0956
Loa Loa (eye worm) AGC/PKA protein kinase 0.0066 0.0246 0.0267
Echinococcus multilocularis NCK adaptor protein 0.0062 0.0203 0.024
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0205 0.1483 0.1609
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0163 0.111 0.1105
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0245 0.1842 0.1998
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.015 0.0995 0.12
Onchocerca volvulus 0.0074 0.0313 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.1842 0.2747
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0161 0.0175
Schistosoma mansoni serine/threonine-protein kinase 0.0169 0.1167 0.174
Echinococcus multilocularis ephrin type A receptor 4 A 0.011 0.0632 0.0761
Loa Loa (eye worm) hypothetical protein 0.014 0.0904 0.0981
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0013 0.0014
Schistosoma mansoni serine/threonine kinase 0.0091 0.0464 0.0692
Loa Loa (eye worm) hypothetical protein 0.0166 0.1134 0.123
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0021 0.002
Echinococcus multilocularis casein kinase I alpha 0.0064 0.0224 0.0265
Brugia malayi Kinase associated domain 1 family protein 0.0071 0.0283 0.0307
Schistosoma mansoni hypothetical protein 0.0467 0.3832 0.5716
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Plasmodium falciparum NIMA related kinase 1 0.0139 0.0898 0.7974
Echinococcus granulosus N chimaerin 0.0074 0.031 0.0305
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0357 0.1386
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0143 0.0928 0.112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0274 0.0409
Schistosoma mansoni septate junction protein 0.004 0.0013 0.002
Brugia malayi Protein kinase domain containing protein 0.007 0.0276 0.03
Echinococcus multilocularis aurora kinase A 0.015 0.0995 0.12
Plasmodium vivax protein kinase Crk2 0.0119 0.0719 0.6407
Entamoeba histolytica protein kinase, putative 0.0103 0.0577 0.2486
Echinococcus granulosus casein kinase I alpha 0.0064 0.0224 0.0219
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0029 0.0029
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0251 0.1899 0.1895
Entamoeba histolytica protein kinase, putative 0.029 0.225 0.9753
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0798 0.3202
Giardia lamblia Kinase, CMGC CDK 0.0119 0.0719 0.2946
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0044 0.0042 0.0078
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0303 0.1299
Onchocerca volvulus 0.007 0.0276 0.0511
Onchocerca volvulus 0.0134 0.0848 0.1622
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0242
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0108 0.0621 0.0617
Echinococcus granulosus mitogen activated protein kinase 3 0.0079 0.0357 0.0352
Echinococcus granulosus mitogen activated protein kinase 0.0079 0.0357 0.0352
Entamoeba histolytica casein kinase, putative 0.0098 0.0526 0.2268
Schistosoma mansoni growth factor receptor-bound protein 0.0062 0.0203 0.0303
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.008 0.0367 0.1272
Echinococcus granulosus growth factor receptor bound protein 2 0.0062 0.0203 0.0198
Echinococcus granulosus tyrosine protein kinase Lyn 0.0185 0.1309 0.1305
Plasmodium vivax unspecified product 0.0098 0.0526 0.4631
Brugia malayi Protein kinase domain containing protein 0.0205 0.1483 0.1609
Brugia malayi Fibronectin type III domain containing protein 0.009 0.0457 0.0496
Echinococcus multilocularis serine threonine protein kinase 0.0195 0.1396 0.1687
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0123 0.0755 0.27
Brugia malayi Casein kinase II, alpha chain 0.0098 0.0526 0.0571
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Echinococcus granulosus dnaJ subfamily B 0.0467 0.3832 0.3829
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.1317 0.1591
Brugia malayi map kinase activated protein kinase protein 2 0.0437 0.3562 0.3865
Trypanosoma brucei protein kinase, putative 0.0056 0.0153 0.0484
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0208 0.0903
Echinococcus granulosus tyrosine protein kinase Fyn 0.0165 0.1128 0.1123
Trichomonas vaginalis AGC family protein kinase 0.015 0.0995 0.4016
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0166 0.1136 0.4101
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0079 0.0357 0.1569
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0029 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0719 0.1073
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0064 0.0224 0.0746
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0064 0.0224 0.0243
Loa Loa (eye worm) TK/ROR protein kinase 0.0055 0.0144 0.0156
Loa Loa (eye worm) hypothetical protein 0.016 0.1084 0.1177
Entamoeba histolytica protein kinase, putative 0.0064 0.0224 0.0956
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0119 0.0719 0.3182
Plasmodium falciparum calcium-dependent protein kinase 5 0.0046 0.0067 0.0005
Schistosoma mansoni tyrosine kinase 0.0072 0.0295 0.044
Loa Loa (eye worm) hypothetical protein 0.0046 0.0066 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Loa Loa (eye worm) hypothetical protein 0.0087 0.0432 0.0469
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0165 0.1128 0.1362
Onchocerca volvulus 0.0094 0.0494 0.0935
Loa Loa (eye worm) AUR protein kinase 0.015 0.0995 0.1079
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0066 0.0099
Giardia lamblia Kinase, NEK 0.0139 0.0898 0.3754
Entamoeba histolytica protein kinase, putative 0.015 0.0995 0.4302
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Brugia malayi SRC-1 0.0165 0.1128 0.1224
Brugia malayi RhoGAP domain containing protein 0.0074 0.031 0.0336
Loa Loa (eye worm) hypothetical protein 0.0103 0.0573 0.0622
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0066 0.0246 0.0829
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0203 0.022
Loa Loa (eye worm) TK/EGFR protein kinase 0.0688 0.5804 0.6297
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0013 0.0014
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.0061 0.0068
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0046 0.0067 0.0275
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0079 0.0357 0.1237
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Onchocerca volvulus 0.014 0.0904 0.1732
Echinococcus granulosus serine:threonine protein kinase N2 0.0148 0.0973 0.0969
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.2283 0.3405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Giardia lamblia Kinase, STE STE20 0.008 0.0367 0.1356
Brugia malayi P38 map kinase family protein 2 0.0166 0.1136 0.1232
Echinococcus granulosus casein kinase I alpha 0.0064 0.0224 0.0219
Echinococcus granulosus serine:threonine protein kinase 3 0.0279 0.2144 0.214
Trichomonas vaginalis STE family protein kinase 0.0082 0.0381 0.1483
Entamoeba histolytica protein kinase, putative 0.0297 0.2307 1
Schistosoma mansoni diacylglycerol kinase theta 0.0039 0.0005 0.0007
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0046 0.0066 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0437 0.3562 0.5313
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0437 0.3562 0.3865
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0165 0.1128 0.1123
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0163 0.111 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Echinococcus granulosus neuroglian 0.0107 0.0605 0.06
Loa Loa (eye worm) RasGEF domain-containing protein 0.0039 0.0005 0.0005
Trypanosoma cruzi p21-activated kinase 3, putative 0.0045 0.0057 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.004 0.0013 0.0014
Echinococcus multilocularis casein kinase I delta 0.0064 0.0224 0.0265
Echinococcus multilocularis rho associated protein kinase 0.0357 0.2849 0.3449
Echinococcus multilocularis epidermal growth factor receptor 0.0448 0.3655 0.4427
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0013 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0246 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0464 0.0692
Echinococcus multilocularis serine:threonine protein kinase 3 0.0279 0.2144 0.2594
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0235 0.1758 0.1754
Schistosoma mansoni titin 0.004 0.0013 0.002
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0158 0.1061 0.1151
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0165 0.1128 0.1123
Onchocerca volvulus 0.0108 0.0615 0.1169
Brugia malayi serine/threonine protein kinase 6 0.015 0.0995 0.1079
Toxoplasma gondii AGC kinase 0.029 0.225 1
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0719 0.288
Echinococcus multilocularis growth factor receptor bound protein 2 0.0062 0.0203 0.024
Echinococcus multilocularis tyrosine protein kinase Abl 0.0189 0.1341 0.162
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0062
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0148 0.0973 0.1056
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0055 0.0144 0.0168
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0041 0.0018 0.0013
Schistosoma mansoni tyrosine kinase 0.0275 0.2112 0.3151
Toxoplasma gondii AGC kinase 0.0066 0.0246 0.1075
Trichomonas vaginalis STE family protein kinase 0.0082 0.0381 0.1483
Echinococcus granulosus tyrosine protein kinase Fyn 0.0165 0.1128 0.1123
Leishmania major mitochondrial DNA polymerase beta 0.0345 0.2739 1
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0045 0.0057 0.0148
Echinococcus multilocularis tyrosine protein kinase otk 0.004 0.0013 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0284 0.2191 0.2377
Trichomonas vaginalis glutaminase, putative 0.0312 0.2446 1
Entamoeba histolytica protein kinase, putative 0.0064 0.0224 0.0956
Echinococcus granulosus activin receptor type 0.0056 0.0153 0.0148
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0076 0.0334 0.0329
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0294 0.2283 0.2279
Trypanosoma cruzi aurora B kinase, putative 0.015 0.0995 0.3583
Echinococcus multilocularis hemicentin 1 0.004 0.0013 0.001
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0043 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0313 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0031 0.0046
Trichomonas vaginalis AGC family protein kinase 0.015 0.0995 0.4016
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0128 0.0799 0.0794
Echinococcus multilocularis tyrosine protein kinase shark 0.007 0.0276 0.0329
Brugia malayi putative serine/threonine kinase SADA gamma 0.0046 0.0066 0.0072
Echinococcus granulosus serine:threonine kinase SAD 1 0.0046 0.0066 0.0061
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0045 0.0057 0.0062
Toxoplasma gondii casein kinase I 0.0064 0.0224 0.0975
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.008 0.0367 0.1575
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.029 0.225 0.2441
Plasmodium falciparum calcium-dependent protein kinase 3 0.0046 0.0067 0.0005
Echinococcus granulosus tyrosine protein kinase shark 0.007 0.0276 0.0271
Trypanosoma brucei cdc2-related kinase 1 0.0119 0.0719 0.2569
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0293
Echinococcus multilocularis peroxidasin 0.0041 0.0016 0.0013
Schistosoma mansoni tyrosine kinase 0.0097 0.0522 0.0779
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0066 0.0246 0.0829
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0046 0.0067 0.0275
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0158 0.1061 0.1057
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0064 0.0224 0.0243
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0166 0.1136 0.4101
Brugia malayi hypothetical protein 0.009 0.0457 0.0496
Trichomonas vaginalis CK1 family protein kinase 0.0064 0.0224 0.0836
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0074 0.031 0.0462
Loa Loa (eye worm) hypothetical protein 0.0137 0.088 0.0954
Brugia malayi SH2 domain containing protein 0.007 0.0276 0.03
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0287 0.2221 0.241
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0973 0.3927
Echinococcus granulosus tyrosine protein kinase Src42A 0.0165 0.1128 0.1123
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0367 0.1272
Entamoeba histolytica protein kinase, putative 0.0297 0.2307 1
Brugia malayi Protein kinase domain containing protein 0.0148 0.0973 0.1056
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0755 0.326
Echinococcus multilocularis cyclin dependent kinase 0.0119 0.0719 0.0866
Echinococcus multilocularis casein kinase I alpha 0.0064 0.0224 0.0265
Schistosoma mansoni tyrosine kinase 0.0412 0.3336 0.4975
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0074 0.031 0.0305
Brugia malayi MH2 domain containing protein 0.0136 0.0872 0.0946
Loa Loa (eye worm) hypothetical protein 0.0046 0.0067 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Echinococcus multilocularis hemicentin 1 0.004 0.0013 0.001
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0045 0.0057 0.0132
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0046 0.0067 0.0072
Loa Loa (eye worm) TK/EPH protein kinase 0.013 0.0813 0.0882
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0161 0.0175
Schistosoma mansoni ste20-related kinase 0.0219 0.1611 0.2402
Echinococcus granulosus tyrosine kinase 0.007 0.0276 0.0271
Loa Loa (eye worm) hypothetical protein 0.0114 0.0671 0.0728
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Brugia malayi cell division control protein 2 homolog 0.0119 0.0719 0.078
Loa Loa (eye worm) hypothetical protein 0.0046 0.0062 0.0067
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0114 0.0676 0.0733
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0066 0.0246 0.0829
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0075
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0102 0.0562 0.0675
Loa Loa (eye worm) hypothetical protein 0.009 0.0457 0.0496
Trypanosoma cruzi casein kinase, putative 0.0064 0.0224 0.0746
Echinococcus granulosus cyclin dependent kinase 0.0119 0.0719 0.0715
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0055 0.0144 0.0139
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0357 0.0533
Toxoplasma gondii AGC kinase 0.0066 0.0246 0.1075
Echinococcus multilocularis microtubule associated protein 2 0.0788 0.6705 0.8125
Brugia malayi Protein kinase domain containing protein 0.0214 0.1565 0.1698
Echinococcus granulosus tyrosine protein kinase ABL1 0.0309 0.2417 0.2413
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.004 0.0013 0.001
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0066 0.0246 0.0267
Echinococcus multilocularis cyclin dependent kinase 5 0.0119 0.0719 0.0866
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0293
Brugia malayi Tyrosine-protein kinase abl-1 0.0189 0.1341 0.1455
Echinococcus multilocularis mitogen activated protein kinase 14 0.0166 0.1136 0.1371
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0181 0.0587
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0066 0.0246 0.0829
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0131 0.0821 0.2944
Trichomonas vaginalis CK1 family protein kinase 0.0064 0.0224 0.0836
Trichomonas vaginalis STE family protein kinase 0.008 0.0367 0.1426
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0021 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0131 0.0821 0.33
Brugia malayi serine/threonine-protein kinase plk-2 0.0294 0.2283 0.2477
Loa Loa (eye worm) hypothetical protein 0.007 0.0276 0.03
Echinococcus granulosus cyclin dependent kinase 5 0.0119 0.0719 0.0715
Echinococcus multilocularis activin receptor type 0.0056 0.0153 0.0179
Leishmania major protein kinase, putative 0.0046 0.0067 0.0168
Echinococcus granulosus nervana 2 0.0143 0.0928 0.0924
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0038 0.0041
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0242
Plasmodium vivax calcium-dependent protein kinase, putative 0.0046 0.0067 0.0401
Onchocerca volvulus 0.007 0.0276 0.0511
Loa Loa (eye worm) hypothetical protein 0.0108 0.0621 0.0674
Echinococcus multilocularis serine:threonine protein kinase 38 0.0148 0.0973 0.1174
Echinococcus multilocularis 0.02 0.1444 0.1746
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0246 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0066 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Echinococcus multilocularis tyrosine protein kinase Blk 0.0137 0.0881 0.1063
Echinococcus multilocularis mitogen activated protein kinase 3 0.0079 0.0357 0.0427
Schistosoma mansoni protein kinase 0.0046 0.0067 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0119 0.0719 0.078
Toxoplasma gondii hypothetical protein 0.0056 0.015 0.0644
Brugia malayi Cam kinase protein 1 0.0046 0.0067 0.0072
Leishmania major casein kinase, putative 0.0064 0.0224 0.0746
Echinococcus multilocularis serine:threonine protein kinase 0.0114 0.0671 0.0808
Echinococcus multilocularis casein kinase ii subunit alpha 0.0098 0.0526 0.0632
Schistosoma mansoni tyrosine kinase 0.0165 0.1128 0.1682
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0279 0.2144 0.2326
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0045 0.0057 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0043 0.0038 0.004
Schistosoma mansoni tyrosine kinase 0.0076 0.0333 0.0496
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0973 0.3927
Echinococcus granulosus c-Jun N-terminal kinases 0.0287 0.2221 0.2217
Echinococcus granulosus roundabout 2 0.0043 0.0038 0.0033
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.0153 0.0484
Brugia malayi Protein kinase domain containing protein 0.0297 0.2307 0.2503
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0166 0.1136 0.1232
Loa Loa (eye worm) hypothetical protein 0.0103 0.0573 0.0622
Echinococcus multilocularis mitogen activated protein kinase 11 0.0166 0.1136 0.1371
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Brugia malayi Sex muscle abnormal protein 5 0.0062 0.0203 0.022
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0165 0.1128 0.1362
Brugia malayi Variant SH3 domain containing protein 0.0074 0.031 0.0336
Brugia malayi protein unc-22 0.0042 0.0031 0.0033
Brugia malayi phosphoinositide-dependent protein kinase I 0.0076 0.0334 0.0362
Trypanosoma cruzi cdc2-related kinase 3 0.0119 0.0719 0.2569
Brugia malayi Protein kinase domain containing protein 0.1069 0.9217 1
Entamoeba histolytica protein kinase, putative 0.0148 0.0973 0.4209
Brugia malayi Protein kinase domain containing protein 0.007 0.0276 0.03
Trichomonas vaginalis AGC family protein kinase 0.015 0.0995 0.4016
Echinococcus granulosus protein kinase C gamma type 0.0195 0.1396 0.1391
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.1278 0.5
Brugia malayi Protein kinase domain containing protein 0.0201 0.1453 0.1577
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0087 0.0432 0.0645
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0046 0.0065 0.006
Echinococcus granulosus Glutaredoxin protein 5 0.0143 0.0928 0.0924
Giardia lamblia Kinase, CMGC CK2 0.0098 0.0526 0.2076
Brugia malayi Protein kinase domain containing protein 0.0148 0.0973 0.1056
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1061 0.1583
Echinococcus granulosus serine:threonine protein kinase 0.0114 0.0671 0.0666
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0184 0.1302 0.1298
Loa Loa (eye worm) TK protein kinase 0.0137 0.0881 0.0956
Echinococcus multilocularis casein kinase I delta 0.0064 0.0224 0.0265
Giardia lamblia Kinase, CMGC CDK 0.0119 0.0719 0.2946
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0872 0.0946
Schistosoma mansoni roundabout 0.004 0.0013 0.002
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0154 0.1029 0.1116
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0973 0.1452
Brugia malayi diacylglycerol kinase 0.0039 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.022
Giardia lamblia Kinase, NEK 0.0139 0.0898 0.3754
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0139 0.0898 0.8054
Onchocerca volvulus Tyrosine kinase homolog 0.0616 0.5158 1
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1302 0.1942
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0082 0.0381 0.0456
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.1565 0.2335
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0076 0.0334 0.0399
Trypanosoma brucei polo-like protein kinase 0.0294 0.2283 0.8324
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0056 0.0153 0.0658
Echinococcus granulosus lysosomal alpha glucosidase 0.0186 0.1317 0.1313
Loa Loa (eye worm) hypothetical protein 0.009 0.0457 0.0496
Echinococcus granulosus dual specificity 0.0123 0.0755 0.075
Schistosoma mansoni hypothetical protein 0.0071 0.0283 0.0422
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0079 0.0357 0.0388
Giardia lamblia Kinase, AGC PKA 0.0163 0.111 0.4708
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0066 0.0099
Schistosoma mansoni tyrosine kinase 0.05 0.4126 0.6154
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0098 0.0526 0.0571
Echinococcus multilocularis rac serine:threonine kinase 0.0169 0.1167 0.1409
Brugia malayi Peroxidasin 0.0041 0.0016 0.0017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0031 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0131 0.0821 0.3549
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0671 0.268
Echinococcus granulosus casein kinase I delta 0.0064 0.0224 0.0219
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0043 0.0038 0.004
Echinococcus granulosus serine/threonine protein kinase 0.0169 0.1167 0.1162
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.025 0.1889 0.2049
Plasmodium falciparum glycogen synthase kinase 3 0.0131 0.0821 0.7235
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0235 0.1758 0.2126
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.134 0.1998
Entamoeba histolytica protein kinase, putative 0.0063 0.0214 0.091
Echinococcus multilocularis roundabout 2 0.0043 0.0038 0.004
Loa Loa (eye worm) AGC/PKN protein kinase 0.0148 0.0973 0.1056
Echinococcus granulosus epidermal growth factor receptor 0.0688 0.5804 0.5802
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0075
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0076 0.0334 0.0362
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0139 0.0898 0.3979
Entamoeba histolytica diacylglycerol kinase, putative 0.0039 0.0005 0.0004
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0046 0.0067 0.0072
Entamoeba histolytica p21-activated kinase 0.0088 0.0438 0.1883
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0062 0.0203 0.022
Echinococcus multilocularis insulin receptor 0.05 0.4126 0.4998
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0163 0.111 0.4006
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0293
Schistosoma mansoni cell adhesion molecule 0.0111 0.0646 0.0964
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0131 0.0821 0.099
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0117 0.0701 0.0761
Entamoeba histolytica protein kinase, putative 0.0076 0.0334 0.1433
Echinococcus multilocularis cyclin dependent kinase 1 0.0119 0.0719 0.0866
Schistosoma mansoni rac gtpase activating protein 0.0039 0.0005 0.0007
Onchocerca volvulus 0.0042 0.0031 0.0034
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0131 0.0821 0.0891
Loa Loa (eye worm) SRC-1 0.0165 0.1128 0.1224
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0054 0.0138 0.0581
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0029 0.0024
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0074 0.031 0.0336
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0076 0.0334 0.0362
Echinococcus granulosus lachesin 0.004 0.0013 0.0008
Brugia malayi MAP kinase sur-1 0.0079 0.0357 0.0388
Echinococcus granulosus fibroblast growth factor receptor 4 0.0265 0.2018 0.2014
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Schistosoma mansoni serine/threonine-protein kinase 0.0169 0.1167 0.174
Entamoeba histolytica PH domain containing protein kinase, putative 0.0169 0.1167 0.5049
Schistosoma mansoni tyrosine kinase 0.05 0.4126 0.6154
Echinococcus granulosus serine:threonine protein kinase 12 B 0.015 0.0995 0.099
Schistosoma mansoni cell adhesion molecule 0.0043 0.0038 0.0057
Echinococcus granulosus protein kinase shaggy 0.0131 0.0821 0.0817
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0067 0.01
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0039 0.0005 0.0005
Echinococcus granulosus serine threonine protein kinase nrc 0.0163 0.111 0.1105
Schistosoma mansoni nephrin 0.0109 0.063 0.094
Schistosoma mansoni protein kinase 0.0046 0.0067 0.01
Trichomonas vaginalis STE family protein kinase 0.0082 0.0381 0.1483
Echinococcus granulosus nervana 2 0.0143 0.0928 0.0924
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0066 0.0246 0.1075
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Echinococcus granulosus casein kinase i 0.0064 0.0224 0.0219
Schistosoma mansoni tyrosine kinase 0.0412 0.3336 0.4975
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0091 0.0464 0.0504
Entamoeba histolytica serine/threonine protein kinase, putative 0.0046 0.0066 0.027
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.008 0.0367 0.1272
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0503 0.4151 0.4148
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0114 0.0671 0.0728
Loa Loa (eye worm) hypothetical protein 0.0128 0.0794 0.0861
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0251 0.1899 0.2297
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0066 0.0246 0.0829
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Schistosoma mansoni alpha glucosidase 0.0041 0.0021 0.0032
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0124 0.0758 0.2712
Plasmodium falciparum protein kinase, putative 0.0056 0.0153 0.0829
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0066 0.0246 0.2054
Loa Loa (eye worm) AGC/NDR protein kinase 0.0148 0.0973 0.1056
Echinococcus granulosus ephrin type A receptor 4 A 0.011 0.0632 0.0627
Echinococcus granulosus tyrosine protein kinase Fyn 0.0165 0.1128 0.1123
Echinococcus multilocularis Glutaredoxin protein 5 0.0143 0.0928 0.112
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1069 0.9217 1
Schistosoma mansoni protein kinase 0.0064 0.0224 0.0334
Trichomonas vaginalis AGC family protein kinase 0.0154 0.103 0.4161
Leishmania major protein kinase, putative 0.008 0.0367 0.1272
Schistosoma mansoni hypothetical protein 0.0071 0.0283 0.0422
Echinococcus multilocularis myotubularin protein 13 0.0046 0.0062 0.0069
Brugia malayi protein kinase C3,putative 0.0155 0.1042 0.1131
Schistosoma mansoni cell adhesion molecule 0.004 0.0013 0.002
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.015 0.0995 0.4302
Plasmodium falciparum protein kinase 5 0.0119 0.0719 0.6259
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0021 0.0023
Echinococcus multilocularis myosin iiia 0.008 0.0367 0.0439
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0149 0.0988 0.0983
Loa Loa (eye worm) hypothetical protein 0.0043 0.0038 0.0041
Leishmania major protein kinase A catalytic subunit 0.0066 0.0246 0.0829
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0119 0.0129
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0189 0.134 0.1454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0119 0.0178
Onchocerca volvulus 0.007 0.0276 0.0511
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0148 0.0973 0.0969
Brugia malayi C1-like domain containing protein 0.0154 0.1029 0.1116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0165 0.1128 0.1362
Trypanosoma brucei protein kinase, putative 0.0079 0.0357 0.1237
Echinococcus granulosus protein kinase c epsilon type 0.0189 0.134 0.1335
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Echinococcus granulosus tyrosine protein kinase Src42A 0.0102 0.0562 0.0557
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0097 0.0522 0.0779
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.0153 0.0484
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0872 0.0946
Loa Loa (eye worm) hypothetical protein 0.02 0.1438 0.156
Entamoeba histolytica cell division protein kinase 2, putative 0.0119 0.0719 0.3106
Brugia malayi Inositol-1 0.0042 0.0029 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0165 0.1128 0.1362
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0242
Echinococcus granulosus cyclin dependent kinase 1 0.0119 0.0719 0.0715
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Trypanosoma cruzi cdc2-related kinase 1 0.0119 0.0719 0.2569
Trypanosoma brucei aurora B kinase 0.015 0.0995 0.3583
Brugia malayi RhoGEF domain containing protein 0.0039 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0094 0.0494 0.0536
Onchocerca volvulus 0.0044 0.0042 0.0057
Schistosoma mansoni protein kinase 0.0235 0.1758 0.2622
Echinococcus multilocularis tyrosine protein kinase HCK 0.0103 0.0577 0.0693
Brugia malayi Immunoglobulin I-set domain containing protein 0.0705 0.5955 0.6461
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0029 0.0033
Trypanosoma brucei casein kinase I, isoform 2 0.0064 0.0224 0.0746
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0205 0.1483 0.1609
Echinococcus granulosus defective proboscis extension response 0.0087 0.0432 0.0428
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0119 0.0719 0.2569
Loa Loa (eye worm) TK/INSR protein kinase 0.05 0.4126 0.4477
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0067 0.0188
Brugia malayi serine/threonine-protein kinase PAK 7 0.025 0.1889 0.2049
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.015 0.0995 0.4302
Echinococcus granulosus calcium activated potassium channel 0.0091 0.0464 0.0459
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0066 0.0246 0.0829
Loa Loa (eye worm) hypothetical protein 0.0041 0.0016 0.0017
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0128 0.0799 0.0962
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0119 0.0138
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0064 0.0224 0.0266
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0029 0.0029
Echinococcus granulosus contactin 0.0043 0.0038 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0021 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Schistosoma mansoni vav2 0.008 0.0367 0.0547
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0309 0.2417 0.2925
Echinococcus multilocularis serine:threonine protein kinase N2 0.0148 0.0973 0.1174
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0029 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0013 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.1749 0.2609
Mycobacterium ulcerans hypothetical protein 0.0182 0.1278 0.5166
Schistosoma mansoni hypothetical protein 0.0039 0.0005 0.0007
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0079 0.0357 0.1237
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0114 0.0671 0.0728
Entamoeba histolytica diacylglycerol kinase, putative 0.0039 0.0005 0.0004
Echinococcus granulosus microtubule associated protein 2 0.0788 0.6705 0.6703
Loa Loa (eye worm) inositol-1 0.0042 0.0029 0.0032
Trichomonas vaginalis STE family protein kinase 0.0056 0.0157 0.056
Schistosoma mansoni tyrosine kinase 0.0448 0.3655 0.5452
Schistosoma mansoni protein kinase 0.0056 0.0153 0.0228
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0303 0.1299
Echinococcus granulosus protein kinase c iota type 0.0283 0.2182 0.2179
Schistosoma mansoni protein kinase 0.0046 0.0067 0.01
Echinococcus multilocularis serine:threonine protein kinase 0.0114 0.0671 0.0808
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0123 0.0755 0.0819
Echinococcus granulosus tyrosine protein kinase HCK 0.0103 0.0577 0.0572
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.2739 1
Toxoplasma gondii histone kinase SNF1, putative 0.0046 0.0066 0.0273
Echinococcus multilocularis mitogen activated protein kinase 11 0.0166 0.1136 0.1371
Onchocerca volvulus 0.0357 0.2849 0.5512
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0143 0.0928 0.0924
Loa Loa (eye worm) raf kinase 0.0039 0.0005 0.0005
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0063 0.022 0.0238
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.1113 0.4016
Echinococcus granulosus tyrosine kinase 0.0137 0.0881 0.0877
Echinococcus granulosus raf serine:threonine protein kinase 0.0075 0.0325 0.032
Schistosoma mansoni diacylglycerol kinase theta 0.0039 0.0005 0.0007
Loa Loa (eye worm) TK/ABL protein kinase 0.0309 0.2417 0.2623
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Echinococcus multilocularis titin 0.0042 0.0031 0.0031
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0186 0.1317 0.1429
Loa Loa (eye worm) hypothetical protein 0.0061 0.0199 0.0216
Echinococcus granulosus c src tyrosine kinase 0.0097 0.0522 0.0518
Onchocerca volvulus 0.007 0.0276 0.0511
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0046 0.0067 0.0062
Brugia malayi Protein kinase domain containing protein 0.0076 0.0334 0.0362
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0062 0.0203 0.0303
Entamoeba histolytica protein kinase, putative 0.0048 0.008 0.0329
Schistosoma mansoni alpha-glucosidase 0.016 0.1085 0.1618
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0046 0.0066 0.0396
Schistosoma mansoni inositol monophosphatase 0.0042 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0128 0.0794 0.0861
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0046 0.0066 0.0166
Echinococcus granulosus unc 13 munc13 0.0041 0.0018 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0719 0.1073
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0068 0.0256 0.0277
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0246 0.0929
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0973 0.1452
Schistosoma mansoni tyrosine kinase 0.0097 0.0522 0.0779
Onchocerca volvulus 0.007 0.0276 0.0511
Schistosoma mansoni serine/threonine kinase 0.0148 0.0973 0.1452
Loa Loa (eye worm) hypothetical protein 0.016 0.1084 0.1177
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0057 0.0085
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0131 0.0821 0.1225
Toxoplasma gondii CMGC kinase, CK2 family 0.0098 0.0526 0.2322
Entamoeba histolytica SH2-protein kinase domain containing protein 0.007 0.0276 0.1181
Schistosoma mansoni protein kinase C 0.0041 0.0018 0.0027
Brugia malayi Ras association domain family 1 isoform A 0.0039 0.0005 0.0005
Entamoeba histolytica protein kinase , putative 0.015 0.0995 0.4302
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.007 0.0276 0.0329
Echinococcus granulosus mitogen activated protein kinase 14 0.0166 0.1136 0.1131
Echinococcus multilocularis serine:threonine protein kinase N2 0.0148 0.0973 0.1174
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0082 0.0381 0.0456
Echinococcus multilocularis protein kinase shaggy 0.0131 0.0821 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0464 0.0692
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0357 0.1386
Schistosoma mansoni protein kinase 0.0082 0.0381 0.0568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0119 0.0114
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0448 0.3655 0.3652
Entamoeba histolytica protein kinase, putative 0.0063 0.0214 0.091
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0127 0.0792 0.3179
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0064 0.0224 0.0243
Brugia malayi Furin-like cysteine rich region family protein 0.0688 0.5804 0.6297
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0029 0.0109
Brugia malayi STE20-like kinase MST 0.0279 0.2144 0.2326
Loa Loa (eye worm) TK protein kinase 0.0103 0.0577 0.0626
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Trypanosoma cruzi casein kinase, putative 0.0064 0.0224 0.0746
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0246 0.0293
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0265 0.2018 0.2441
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0046 0.0066 0.0074
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0158 0.1061 0.1151
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0334 0.129
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.008 0.0367 0.1575
Entamoeba histolytica protein kinase domain containing protein 0.0131 0.0821 0.3549
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0029 0.5
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0162 0.1105 0.1199
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0161 0.0175
Echinococcus granulosus roundabout 2 0.013 0.0819 0.0814
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0038 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0029 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0799 0.1191
Leishmania major protein kinase A catalytic subunit isoform 2 0.0066 0.0246 0.0829
Echinococcus granulosus casein kinase ii subunit alpha 0.0098 0.0526 0.0522
Echinococcus multilocularis mitogen activated protein kinase 14 0.0166 0.1136 0.1371
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0184 0.1302 0.1573
Trichomonas vaginalis CK1 family protein kinase 0.0064 0.0224 0.0836
Echinococcus multilocularis PAK box P21 Rho binding 0.0056 0.0157 0.0184
Brugia malayi p70 ribosomal S6 kinase beta 0.029 0.225 0.2441
Brugia malayi Protein kinase domain containing protein 0.007 0.0276 0.03
Trypanosoma cruzi cdc2-related kinase 1 0.0119 0.0719 0.2569
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0046 0.0067 0.0168
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0064 0.0224 0.0219
Onchocerca volvulus 0.0131 0.0821 0.157
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0046 0.0067 0.0401
Entamoeba histolytica hypothetical protein 0.0123 0.0755 0.326
Schistosoma mansoni neuroglian 0.0043 0.0038 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0357 0.1386
Loa Loa (eye worm) hypothetical protein 0.0046 0.0061 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0165 0.1128 0.1362
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0464 0.1827
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0087 0.0432 0.0518
Echinococcus multilocularis casein kinase i 0.0064 0.0224 0.0265
Onchocerca volvulus Serine\/threonine kinase homolog 0.0294 0.2283 0.4412
Schistosoma mansoni cell adhesion molecule 0.0043 0.0038 0.0057
Schistosoma mansoni nephrin 0.0043 0.0038 0.0057
Echinococcus multilocularis protein kinase c iota type 0.0283 0.2182 0.2641
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0131 0.0821 0.2944
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0046 0.0066 0.0166
Echinococcus multilocularis twitchin 0.004 0.0006 0.0001
Onchocerca volvulus 0.0561 0.4666 0.9043
Echinococcus multilocularis nervana 2 0.0143 0.0928 0.112
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0154 0.1029 0.1116
Schistosoma mansoni tyrosine kinase 0.0165 0.1128 0.1682
Entamoeba histolytica PH domain containing protein kinase, putative 0.0169 0.1167 0.5049
Plasmodium falciparum casein kinase 2, alpha subunit 0.0098 0.0526 0.4409
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0042 0.0031 0.0033
Brugia malayi casein kinase 1, delta 0.0064 0.0224 0.0243
Echinococcus granulosus aurora kinase A 0.015 0.0995 0.099
Echinococcus granulosus serine:threonine protein kinase 0.0114 0.0671 0.0666
Schistosoma mansoni tyrosine kinase 0.0412 0.3336 0.4975
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0046 0.0066 0.0072
Entamoeba histolytica protein kinase, putative 0.0123 0.0755 0.326
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0086 0.0237
Schistosoma mansoni atypical protein kinase C 0.029 0.2245 0.3349
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0131 0.0821 0.0891
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0123 0.0755 0.27
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0082 0.0381 0.0376
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.0153 0.0484
Echinococcus granulosus Protein kinase C brain isozyme 0.0234 0.1749 0.1745
Trypanosoma cruzi Protein kinase B 0.0169 0.1167 0.4215
Echinococcus granulosus rho-associated protein kinase 1 0.0357 0.2849 0.2846
Loa Loa (eye worm) hypothetical protein 0.016 0.1084 0.1177
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0357 0.1386
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0079 0.0357 0.1237
Onchocerca volvulus 0.016 0.1084 0.2082
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0265 0.2018 0.2014
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0119 0.0719 0.2569
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0158 0.1061 0.1281
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0357 0.1237
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0119 0.0129
Trypanosoma brucei rac serine-threonine kinase, putative 0.0297 0.2307 0.8411
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.002
Schistosoma mansoni protein kinase 0.015 0.0995 0.1484
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0224 0.0334
Echinococcus multilocularis c src tyrosine kinase 0.0097 0.0522 0.0628
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.015 0.0995 0.4302
Schistosoma mansoni protein kinase C mu 0.0154 0.1029 0.1535
Brugia malayi Glycosyl hydrolases family 31 protein 0.0186 0.1317 0.1429
Onchocerca volvulus 0.0064 0.0224 0.0409
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0043 0.0038 0.004
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0046 0.0067 0.0401
Onchocerca volvulus 0.0041 0.0018 0.0009
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0165 0.1128 0.1362
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0245 0.1842 0.1838
Brugia malayi Protein kinase domain containing protein 0.0123 0.0755 0.0819
Trichomonas vaginalis STE family protein kinase 0.0139 0.0898 0.3618
Giardia lamblia Kinase, STE STE20 0.0082 0.0381 0.1419
Brugia malayi Immunoglobulin I-set domain containing protein 0.009 0.0457 0.0496
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Leishmania major protein kinase A catalytic subunit isoform 1 0.0066 0.0246 0.0829
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0169 0.1167 0.4215
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0021 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0057 0.0085
Brugia malayi Tyrosine-protein kinase abl-1 0.0148 0.0974 0.1057
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0075
Echinococcus multilocularis dual specificity 0.0123 0.0755 0.0909
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0148 0.0973 0.1174
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.004 0.0013 0.0014
Schistosoma mansoni microtubule-associated protein tau 0.0788 0.6705 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0074 0.031 0.0462
Echinococcus granulosus twitchin 0.0127 0.0787 0.0782
Trypanosoma brucei SNF1-related protein kinases, putative 0.0046 0.0066 0.0166
Echinococcus multilocularis N chimaerin 0.0074 0.031 0.037
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0294 0.2283 0.2763
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0045 0.0057 0.0062
Loa Loa (eye worm) glutaminase 0.0312 0.2446 0.2654
Entamoeba histolytica serine/threonine protein kinase, putative 0.0294 0.2283 0.9897
Plasmodium falciparum calcium-dependent protein kinase 2 0.0046 0.0067 0.0005
Plasmodium falciparum calcium-dependent protein kinase 4 0.0046 0.0067 0.0005
Loa Loa (eye worm) TK protein kinase 0.0284 0.2191 0.2377
Loa Loa (eye worm) AGC/AKT protein kinase 0.0297 0.2307 0.2503
Brugia malayi serine/threonine-protein kinase 6 0.015 0.0995 0.1079
Loa Loa (eye worm) hypothetical protein 0.0087 0.0432 0.0469
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0276 0.03
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0265 0.2018 0.2441
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0062
Trypanosoma cruzi casein kinase II, putative 0.0098 0.0526 0.1859
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.1113 0.4016
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0148 0.0973 0.0969
Loa Loa (eye worm) hypothetical protein 0.0127 0.079 0.0857
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0148 0.0973 0.1174
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.0881 0.1063
Plasmodium vivax casein kinase 1, putative 0.0064 0.0224 0.1847
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0719 0.288
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.2283 0.9329
Schistosoma mansoni nck2/grb4 0.0062 0.0203 0.0303
Echinococcus granulosus NDR protein kinase 0.0148 0.0973 0.0969
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.004 0.0013 0.002
Brugia malayi Hr1 repeat family protein 0.0148 0.0973 0.1056
Loa Loa (eye worm) hypothetical protein 0.0085 0.0414 0.045
Brugia malayi diacylglycerol kinase 0.0039 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0066 0.0099
Echinococcus multilocularis protein kinase c epsilon type 0.0189 0.134 0.1619
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0153 0.0646
Schistosoma mansoni tyrosine kinase 0.0265 0.2018 0.301
Schistosoma mansoni adapter molecule crk 0.0062 0.0203 0.0303
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0137 0.0881 0.0877
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0184 0.1302 0.1298
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0066 0.0246 0.0829
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0214 0.1565 0.1892
Entamoeba histolytica cell division protein kinase 2, putative 0.0119 0.0719 0.3106
Loa Loa (eye worm) hypothetical protein 0.0094 0.0494 0.0536
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0082 0.0381 0.0376
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0503 0.4151 0.5028
Echinococcus multilocularis Immunoglobulin 0.0087 0.0432 0.0518
Echinococcus granulosus tyrosine protein kinase Srms 0.007 0.0276 0.0271
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0205 0.1483 0.1609
Echinococcus multilocularis roundabout 2 0.013 0.0819 0.0987
Entamoeba histolytica casein kinase 1, putative 0.0064 0.0224 0.0954
Schistosoma mansoni alpha-glucosidase 0.016 0.1085 0.1618
Brugia malayi Prion-like- 0.004 0.0013 0.0014
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0046 0.0067 0.0275
Schistosoma mansoni inositol monophosphatase 0.0042 0.0029 0.0044
Echinococcus granulosus neuroglian 0.0043 0.0038 0.0033
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0165 0.1128 0.1362
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0123 0.0755 0.27
Brugia malayi Protein kinase domain containing protein 0.05 0.4126 0.4477
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0006 0.0009
Brugia malayi Protein kinase domain containing protein 0.0197 0.1414 0.1535
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0042 0.0026 0.0029
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0062 0.0203 0.022
Echinococcus granulosus casein kinase I alpha 0.0064 0.0224 0.0219
Trypanosoma cruzi polo-like protein kinase, putative 0.0294 0.2283 0.8324
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0287 0.2221 0.2687
Echinococcus granulosus epidermal growth factor receptor 0.0448 0.3655 0.3652
Schistosoma mansoni serine/threonine protein kinase 0.0357 0.2849 0.425
Schistosoma mansoni septate junction protein 0.004 0.0013 0.002
Echinococcus granulosus hemicentin 1 0.004 0.0013 0.0008
Entamoeba histolytica protein kinase 2, putative 0.0163 0.111 0.4802
Echinococcus granulosus tyrosine protein kinase Blk 0.0137 0.0881 0.0877
Brugia malayi Protein kinase domain containing protein 0.007 0.0276 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0464 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0199 0.0735
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0119 0.0138
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0079 0.0357 0.1237
Echinococcus multilocularis unc 13 (munc13) 0.0041 0.0018 0.0016
Brugia malayi Protein kinase c protein 2 0.0107 0.0609 0.0661
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0021 0.0072
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0119 0.0719 0.0715
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0973 0.1452
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.1113 0.4016
Schistosoma mansoni tyrosine kinase 0.007 0.0276 0.0412
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0086 0.0237
Brugia malayi intracellular kinase 0.0131 0.0821 0.0891
Brugia malayi SH2 domain containing protein 0.007 0.0276 0.03
Echinococcus granulosus tyrosine protein kinase Src64B 0.0165 0.1128 0.1123
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.0061 0.0068
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0705 0.5955 0.6461
Leishmania major casein kinase II, putative 0.0098 0.0526 0.1859
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0184 0.1302 0.1573
Trichomonas vaginalis AGC family protein kinase 0.0148 0.0973 0.3927
Giardia lamblia Kinase, CMGC MAPK 0.0079 0.0357 0.1313
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0119 0.0719 0.078
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0798 0.3202
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0131 0.0821 0.0817
Echinococcus multilocularis nervana 2 0.0143 0.0928 0.112
Entamoeba histolytica protein kinase, putative 0.0056 0.0157 0.0664
Loa Loa (eye worm) hypothetical protein 0.0066 0.0246 0.0267
Trypanosoma cruzi cdc2-related kinase 3 0.0119 0.0719 0.2569
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0087 0.0432 0.0645
Echinococcus granulosus NCK adaptor protein 0.0062 0.0203 0.0198
Schistosoma mansoni tyrosine kinase 0.0224 0.1653 0.2465
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0064 0.0224 0.0219
Echinococcus multilocularis neuroglian 0.0107 0.0605 0.0728
Echinococcus multilocularis neuroglian 0.0043 0.0038 0.004
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0098 0.0526 0.4631
Echinococcus granulosus casein kinase I delta 0.0064 0.0224 0.0219
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0086 0.0237
Onchocerca volvulus 0.0337 0.2668 0.5159
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0046 0.0065 0.0073
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0005 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.015 0.0995 0.4302
Entamoeba histolytica protein kinase, putative 0.0123 0.0755 0.326
Loa Loa (eye worm) hypothetical protein 0.0134 0.0848 0.092
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Echinococcus multilocularis tyrosine kinase 0.007 0.0276 0.0329
Plasmodium falciparum casein kinase 1 0.0064 0.0224 0.1511
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0719 0.288
Echinococcus multilocularis calcium activated potassium channel 0.0091 0.0464 0.0557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0038 0.0041
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0029 0.0033
Brugia malayi Stress-activated protein kinase jnk-1 0.0287 0.2221 0.241
Echinococcus multilocularis epidermal growth factor receptor 0.0688 0.5804 0.7033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0029 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0297 0.2307 0.9427
Brugia malayi ephrin receptor 1 precursor 0.0071 0.0283 0.0307
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0214 0.1565 0.1698
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0046 0.0067 0.0072
Trypanosoma cruzi casein kinase, putative 0.0064 0.0224 0.0746
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0046 0.0067 0.0062
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0214 0.1565 0.1561
Schistosoma mansoni kinase 0.0315 0.2473 0.3689
Entamoeba histolytica casein kinase, putative 0.0064 0.0224 0.0954
Schistosoma mansoni protein kinase C mu 0.0039 0.0005 0.0007
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0437 0.3562 0.3559
Echinococcus multilocularis mitogen activated protein kinase 0.0079 0.0357 0.0427
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0064 0.0224 0.0266
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.2739 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0014
Echinococcus multilocularis tyrosine protein kinase Srms 0.0137 0.0881 0.1063
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0066 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0334 0.129
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0043 0.0038 0.0057
Entamoeba histolytica protein kinase, putative 0.015 0.0995 0.4302
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0021 0.0074
Giardia lamblia Kinase, NEK 0.0139 0.0898 0.3754
Echinococcus multilocularis lachesin 0.004 0.0013 0.001
Trypanosoma brucei cdc2-related kinase 3 0.0119 0.0719 0.2569
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0013 0.0014
Brugia malayi Protein kinase domain containing protein 0.0091 0.0464 0.0504
Brugia malayi hypothetical protein 0.007 0.0276 0.03
Giardia lamblia Kinase, PLK 0.0294 0.2283 1
Entamoeba histolytica protein kinase, putative 0.0082 0.0381 0.1636
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.2221 0.3312
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0131 0.0821 0.3636
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0013 0.0014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0086 0.0237
Echinococcus multilocularis roundabout 2 0.0043 0.0038 0.004
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.0061 0.0056
Loa Loa (eye worm) AUR protein kinase 0.015 0.0995 0.1079
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0526 0.2084
Trypanosoma brucei Casein kinase II 0.0098 0.0526 0.1859
Brugia malayi Pleckstrin Homology Domain 0.0046 0.0062 0.0067
Schistosoma mansoni vesicular amine transporter 0.0087 0.0432 0.0645
Schistosoma mansoni tyrosine kinase 0.0688 0.5804 0.8657
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0046 0.0067 0.0401
Plasmodium vivax glycogen synthase kinase 3, putative 0.0131 0.0821 0.7344
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0799 0.1191
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0163 0.111 0.134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0119 0.0178
Schistosoma mansoni growth factor receptor-bound protein 0.0062 0.0203 0.0303
Trichomonas vaginalis AGC family protein kinase 0.0139 0.0898 0.3618
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0755 0.1126
Brugia malayi Protein kinase domain 0.0082 0.0381 0.0413
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0099 0.0538 0.0584
Echinococcus granulosus roundabout 2 0.0043 0.0038 0.0033
Trypanosoma cruzi casein kinase, putative 0.0064 0.0224 0.0746
Echinococcus granulosus mitogen activated protein kinase 11 0.0166 0.1136 0.1131
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0334 0.0498
Toxoplasma gondii aurora kinase 0.015 0.0995 0.4409
Brugia malayi serine/threonine kinase 12 0.015 0.0995 0.1079
Giardia lamblia Kinase, AGC PKA 0.0066 0.0246 0.0813
Schistosoma mansoni tyrosine kinase 0.0448 0.3655 0.5452
Echinococcus granulosus tyrosine protein kinase otk 0.004 0.0013 0.0008
Giardia lamblia Kinase, AGC AKT 0.0117 0.0701 0.2866
Trichomonas vaginalis STE family protein kinase 0.0082 0.0381 0.1483
Schistosoma mansoni titin 0.0042 0.0031 0.0046
Echinococcus granulosus tyrosine protein kinase Fps85D 0.007 0.0276 0.0271
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0043 0.0038 0.0033

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 20.18808746 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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