Detailed information for compound 1208126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.901 | Formula: C17H15ClFN3O2S2
  • H donors: 2 H acceptors: 4 LogP: 4.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)Cl)CSCc1nc(O)c2c(n1)sc(c2C)C
  • InChi: 1S/C17H15ClFN3O2S2/c1-8-9(2)26-17-15(8)16(24)21-13(22-17)6-25-7-14(23)20-12-4-3-10(18)5-11(12)19/h3-5H,6-7H2,1-2H3,(H,20,23)(H,21,22,24)
  • InChiKey: QMURLDGYSDJUME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0088 0.0795 0.1392
Onchocerca volvulus 0.0277 0.2807 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0311 0.0326
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0088 0.0795 0.1392
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0125 0.03
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0448 0.0489
Brugia malayi Ceramide kinase 0.0021 0.0086 0.0207
Brugia malayi Sodium:solute symporter family protein 0.0045 0.0337 0.0808
Leishmania major hypothetical protein, conserved 0.0021 0.0086 0.1085
Brugia malayi Intermediate filament tail domain containing protein 0.0088 0.0795 0.1906
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0781
Leishmania major hypothetical protein, conserved 0.0017 0.0043 0.0437
Trichomonas vaginalis bmru protein, putative 0.0021 0.0086 0.0259
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0086 0.1085
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0219 0.3081
Trichomonas vaginalis sphingosine kinase, putative 0.0021 0.0086 0.0259
Echinococcus multilocularis microtubule associated protein 2 0.0806 0.842 0.8414
Schistosoma mansoni zinc finger protein 0.0025 0.0125 0.0104
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0162 0.0125
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0043 0.0006
Brugia malayi intermediate filament protein 0.0088 0.0795 0.1906
Echinococcus granulosus geminin 0.0179 0.1764 0.2059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0414 0.0712
Echinococcus multilocularis high affinity choline transporter 1 0.0406 0.4173 0.415
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0403 0.0966
Brugia malayi jmjC domain containing protein 0.0017 0.0043 0.0103
Leishmania major sphingosine kinase A, B, putative 0.0021 0.0086 0.1085
Schistosoma mansoni cpg binding protein 0.0035 0.0234 0.0234
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0162 0.0148
Plasmodium vivax diacylglycerol kinase, putative 0.0021 0.0086 0.2206
Echinococcus multilocularis solute carrier family 5 0.0045 0.0337 0.03
Brugia malayi diacylglycerol kinase 0.0021 0.0086 0.0207
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0043 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0057 0.0138
Echinococcus multilocularis snurportin 1 0.036 0.3679 0.3655
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0611 0.0575
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0271 0.0649
Brugia malayi RNA binding protein 0.0071 0.0611 0.1465
Trypanosoma brucei glucosidase, putative 0.0039 0.0271 0.385
Echinococcus granulosus snurportin 1 0.036 0.3679 0.4344
Leishmania major hypothetical protein, conserved 0.0021 0.0086 0.1085
Loa Loa (eye worm) hypothetical protein 0.0034 0.0219 0.0366
Echinococcus granulosus solute carrier family 5 0.0045 0.0337 0.0357
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0147 0.1998
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0452 0.0494
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0271 0.0919
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.068 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0311 0.0274
Trypanosoma cruzi ISWI complex protein 0.0018 0.0053 0.0585
Schistosoma mansoni sphingoid long chain base kinase 0.0543 0.5628 0.6669
Schistosoma mansoni hypothetical protein 0.0051 0.0403 0.0436
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0482
Loa Loa (eye worm) hypothetical protein 0.0045 0.0342 0.0583
Echinococcus multilocularis musashi 0.0088 0.0795 0.076
Trypanosoma brucei diacylglycerol kinase, putative 0.0021 0.0086 0.1085
Schistosoma mansoni cpg binding protein 0.0035 0.0234 0.0234
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0021 0.0086 0.0048
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0627 0.0703
Schistosoma mansoni survival motor neuron protein 0.0051 0.0403 0.0436
Schistosoma mansoni alpha-glucosidase 0.0149 0.1448 0.1682
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0043 0.0006
Plasmodium falciparum diacylglycerol kinase, putative 0.0021 0.0086 0.2453
Echinococcus granulosus sodium:myo inositol cotransporter 0.0045 0.0337 0.0357
Onchocerca volvulus 0.01 0.0927 0.327
Schistosoma mansoni hypothetical protein 0.036 0.3679 0.4344
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0125 0.1768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0448 0.0489
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0021 0.0086 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0448 0.0489
Schistosoma mansoni intermediate filament proteins 0.0088 0.0795 0.0903
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0125 0.0104
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0021 0.0086 0.1085
Echinococcus multilocularis sphingosine kinase 1 0.0543 0.5628 0.5611
Brugia malayi jmjC domain containing protein 0.0017 0.0043 0.0103
Echinococcus granulosus microtubule associated protein 2 0.0806 0.842 1
Brugia malayi diacylglycerol kinase 0.0021 0.0086 0.0207
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0043 0.0437
Echinococcus granulosus sodium:glucose cotransporter 0.0045 0.0337 0.0357
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0219 0.3081
Schistosoma mansoni hypothetical protein 0.0179 0.1764 0.2059
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0086 0.0259
Onchocerca volvulus 0.0031 0.0191 0.0635
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0125 0.1665
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0045 0.0337 0.03
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0271 0.0919
Onchocerca volvulus 0.0088 0.0795 0.2797
Mycobacterium tuberculosis Diacylglycerol kinase 0.0021 0.0086 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0057 0.0023
Leishmania major GTP-binding protein, putative 0.0025 0.0125 0.1665
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0271 0.0919
Leishmania major diacylglycerol kinase, putative 0.0021 0.0086 0.1085
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0021 0.0086 0.0983
Brugia malayi Cytochrome P450 family protein 0.0027 0.0147 0.0353
Echinococcus multilocularis GPCR, family 2 0.0018 0.0057 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0152 0.0493
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0043 0.0006
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0038 0.0361
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.0452 0.0494
Brugia malayi TAR-binding protein 0.0071 0.0611 0.1465
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0043 0.0437
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.068 0.0645
Trypanosoma brucei ISWI complex protein 0.0018 0.0053 0.0585
Loa Loa (eye worm) hypothetical protein 0.0041 0.0295 0.0501
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0021 0.0086 0.0259
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0021 0.0086 0.1085
Entamoeba histolytica diacylglycerol kinase, putative 0.0021 0.0086 0.0129
Echinococcus granulosus lamin dm0 0.0088 0.0795 0.0903
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0086 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0611 0.0684
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1242 0.2188
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0271 0.0919
Brugia malayi Eye-specific diacylglycerol kinase 0.0021 0.0086 0.0207
Brugia malayi Pre-SET motif family protein 0.0036 0.0239 0.0573
Trichomonas vaginalis set domain proteins, putative 0.0277 0.2807 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0239 0.024
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0021 0.0086 0.0259
Schistosoma mansoni alpha-glucosidase 0.0149 0.1448 0.1682
Leishmania major cytochrome p450-like protein 0.0027 0.0147 0.1998
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.068 0.1187
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0147 0.0237
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0448 0.0773
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0125 0.0087
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0038 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0448 0.0489
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0611 0.1465
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.252 0.4464
Schistosoma mansoni hypothetical protein 0.0018 0.0057 0.0023
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0542 0.0601
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0075 0.0037
Schistosoma mansoni inositol transporter 0.0045 0.0337 0.0357
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0043 0.0052
Echinococcus granulosus cpg binding protein 0.0035 0.0234 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0611 0.0684
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0043 0.0006
Echinococcus multilocularis geminin 0.0179 0.1764 0.1732
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0219 0.369
Brugia malayi Pre-SET motif family protein 0.0244 0.245 0.5872
Brugia malayi Cytochrome P450 family protein 0.0017 0.0038 0.0091
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0147 0.0237
Loa Loa (eye worm) hypothetical protein 0.0083 0.0746 0.1304
Trypanosoma cruzi diacylglycerol kinase, putative 0.0021 0.0086 0.1085
Schistosoma mansoni hypothetical protein 0.0021 0.0086 0.0058
Loa Loa (eye worm) RNA binding protein 0.0071 0.0611 0.1064
Plasmodium vivax SET domain protein, putative 0.0036 0.0239 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0271 0.0457
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.048 0.1151
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0271 0.0919
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.068 0.1631
Schistosoma mansoni hypothetical protein 0.0018 0.0057 0.0023
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0038 0.0361
Brugia malayi Cytochrome P450 family protein 0.0027 0.0147 0.0353
Mycobacterium ulcerans hypothetical protein 0.0543 0.5628 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0043 0.0006
Brugia malayi Cytochrome P450 family protein 0.0061 0.0513 0.123
Loa Loa (eye worm) ceramide kinase 0.0021 0.0086 0.0129
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0219 0.0182
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0083 0.0122
Trypanosoma cruzi Sphingosine kinase 0.0021 0.0086 0.1085
Loa Loa (eye worm) hypothetical protein 0.0058 0.048 0.083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0125 0.1665
Brugia malayi PHD-finger family protein 0.0031 0.0192 0.046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0125 0.1665
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0052
Schistosoma mansoni sphingosine kinase A B 0.0543 0.5628 0.6669
Loa Loa (eye worm) hypothetical protein 0.0086 0.0778 0.1361
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.245 0.4339
Loa Loa (eye worm) hypothetical protein 0.0021 0.0086 0.0129
Brugia malayi Importin beta-1 subunit 0.0034 0.0219 0.0526
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0271 0.4732
Brugia malayi hypothetical protein 0.025 0.2516 0.603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0239 0.024
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0021 0.0086 0.0058
Onchocerca volvulus 0.0045 0.0337 0.1157
Schistosoma mansoni zinc finger protein 0.0018 0.0053 0.0018
Brugia malayi Bromodomain containing protein 0.0045 0.0341 0.0816
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0038 0.0361
Loa Loa (eye worm) hypothetical protein 0.0041 0.0295 0.0501
Brugia malayi follicle stimulating hormone receptor 0.025 0.252 0.6039
Brugia malayi jmjC domain containing protein 0.0017 0.0043 0.0103
Entamoeba histolytica hypothetical protein, conserved 0.0543 0.5628 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.068 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0125 0.0198
Echinococcus granulosus intermediate filament protein 0.0088 0.0795 0.0903
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0271 0.0919
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0611 0.1064
Echinococcus granulosus Diacylglycerol kinase zeta 0.0021 0.0086 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0271 0.385
Trypanosoma cruzi Sphingosine kinase 0.0021 0.0086 0.1085
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0585 0.0652
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0043 0.0052
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0014 0.0034
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0021 0.0086 0.0259
Trypanosoma brucei Sphingosine kinase 0.0021 0.0086 0.1085
Entamoeba histolytica Ran family GTPase 0.0025 0.0125 0.0198
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0125 0.4643
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0284 0.0682
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0162 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0448 0.0489
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0021 0.0086 0.0058
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0043 0.0006
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0043 0.0006
Onchocerca volvulus 0.0021 0.0086 0.0259
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.068 0.0766
Schistosoma mansoni lamin 0.0088 0.0795 0.0903
Trichomonas vaginalis ran, putative 0.0025 0.0125 0.0397
Echinococcus multilocularis lamin dm0 0.0088 0.0795 0.076
Schistosoma mansoni bromodomain containing protein 0.0076 0.0672 0.0756
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.012 0.0188
Onchocerca volvulus 0.0051 0.0403 0.1393
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1704 0.1672
Schistosoma mansoni alpha glucosidase 0.0039 0.0271 0.0277
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0152 0.0493
Brugia malayi CXXC zinc finger family protein 0.0031 0.0191 0.0459
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1242 0.2188
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0147 0.0195
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0542 0.0506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0452 0.0494
Echinococcus granulosus tar DNA binding protein 0.0071 0.0611 0.0684
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0043 0.0052
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.1704 0.4084
Brugia malayi cytochrome P450 0.0017 0.0038 0.0091
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0312 0.0275
Brugia malayi jmjC domain containing protein 0.0068 0.0585 0.1401
Trichomonas vaginalis sphingosine kinase, putative 0.0021 0.0086 0.0259
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0057 0.0023
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0038 0.0361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.048 0.1151
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0271 0.0457
Schistosoma mansoni hypothetical protein 0.0024 0.012 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0513 0.0889
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0448 0.0411
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0125 0.5
Plasmodium falciparum importin beta, putative 0.0034 0.0219 1
Leishmania major diacylglycerol kinase-like protein 0.0021 0.0086 0.1085
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0611 0.1064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0542 0.0506
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1704 0.1672
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0057 0.0138
Schistosoma mansoni high-affinity choline transporter 0.0406 0.4173 0.4933
Schistosoma mansoni importin beta-1 0.0034 0.0219 0.0216
Echinococcus multilocularis zinc finger protein 0.0025 0.0125 0.0088
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2516 0.2487
Plasmodium vivax diacylglycerol kinase, putative 0.0021 0.0086 0.2206
Echinococcus granulosus ceramide kinase 0.0021 0.0086 0.0058
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.068 0.1187
Loa Loa (eye worm) hypothetical protein 0.025 0.2516 0.4457
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0542 0.0601
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.1704 0.301
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0057 0.0019
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0038 0.0361
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0218 0.0215
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.036 0.3679 0.6529
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0043 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0611 0.0684
Echinococcus granulosus sodium:glucose cotransporter 2 0.0045 0.0337 0.0357
Loa Loa (eye worm) hypothetical protein 0.0543 0.5628 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0045 0.0337 0.6089
Loa Loa (eye worm) hypothetical protein 0.0045 0.0337 0.0576
Schistosoma mansoni lamin 0.0088 0.0795 0.0903
Brugia malayi GH02984p 0.0406 0.4173 1
Schistosoma mansoni inositol transporter 0.0045 0.0337 0.0357
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0045 0.0337 0.03
Loa Loa (eye worm) cytochrome P450 0.0017 0.0038 0.0043
Onchocerca volvulus 0.0036 0.0239 0.0806
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0147 0.0237
Loa Loa (eye worm) hypothetical protein 0.0042 0.0312 0.0531
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.048 0.083
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0021 0.0086 0.0058
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0271 0.0233
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0075 0.0044
Leishmania major cytochrome p450-like protein 0.0017 0.0038 0.0361
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.068 1
Echinococcus multilocularis ceramide kinase 0.0021 0.0086 0.0048
Plasmodium falciparum diacylglycerol kinase, putative 0.0021 0.0086 0.2453
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0052
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0043 0.0006
Trichomonas vaginalis diacylglycerol kinase, putative 0.0021 0.0086 0.0259
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0362 0.062
Brugia malayi jmjC domain containing protein 0.0017 0.0043 0.0103
Onchocerca volvulus 0.0088 0.0795 0.2797
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0021 0.0086 0.0983
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.1704 0.1988
Trypanosoma cruzi ISWI complex protein 0.0018 0.0053 0.0585
Entamoeba histolytica hypothetical protein 0.0027 0.0152 0.0245
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0021 0.0086 0.1085
Brugia malayi jmjC domain containing protein 0.0064 0.0542 0.1299
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.068 0.0766
Schistosoma mansoni ran 0.0025 0.0125 0.0104
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0585 0.1016
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0021 0.0086 0.1085
Schistosoma mansoni cpg binding protein 0.0031 0.0191 0.0183
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.0452 0.0416
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0585 0.0652
Echinococcus granulosus GPCR family 2 0.0018 0.0057 0.0023
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.4556 0.4535
Echinococcus granulosus lamin 0.0088 0.0795 0.0903
Entamoeba histolytica diacylglycerol kinase, putative 0.0021 0.0086 0.0129
Schistosoma mansoni ran 0.0025 0.0125 0.0104
Schistosoma mansoni sodium/solute symporter 0.0045 0.0337 0.0357
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0043 0.0103
Trichomonas vaginalis diacylglycerol kinase, putative 0.0021 0.0086 0.0259
Schistosoma mansoni hypothetical protein 0.0018 0.0057 0.0023
Trichomonas vaginalis bmru protein, putative 0.0021 0.0086 0.0259
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0125 0.4174
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0075 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0271 0.0919
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0271 0.0457
Brugia malayi RNA, U transporter 1 0.0096 0.0879 0.2106
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0336 0.0299
Loa Loa (eye worm) hypothetical protein 0.0088 0.0795 0.1392
Loa Loa (eye worm) hypothetical protein 0.0021 0.0086 0.0129
Loa Loa (eye worm) hypothetical protein 0.0048 0.0371 0.0636
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0021 0.0086 0.0048
Schistosoma mansoni microtubule-associated protein tau 0.0806 0.842 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.0021 0.0086 0.0259
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0045 0.0337 0.03
Entamoeba histolytica diacylglycerol kinase, putative 0.0021 0.0086 0.0129
Echinococcus multilocularis lamin 0.0088 0.0795 0.076
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0271 0.0919
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0239 0.4093
Echinococcus multilocularis cpg binding protein 0.0035 0.0234 0.0197
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0627 0.0591
Mycobacterium tuberculosis Conserved protein 0.0543 0.5628 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0271 0.385
Trypanosoma cruzi diacylglycerol kinase, putative 0.0021 0.0086 0.1085
Echinococcus multilocularis Diacylglycerol kinase theta 0.0021 0.0086 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0575 0.064
Echinococcus granulosus phd:f box containing protein 0.0017 0.0043 0.0006
Leishmania major hypothetical protein, conserved 0.0018 0.0053 0.0585
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0043 0.0437
Entamoeba histolytica diacylglycerol kinase, putative 0.0021 0.0086 0.0129
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0152 0.2066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0529 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0191 0.0316
Mycobacterium leprae putative cytochrome p450 0.0017 0.0038 0.5
Echinococcus granulosus importin subunit beta 1 0.0034 0.0219 0.0216
Toxoplasma gondii diacylglycerol kinase, putative 0.0021 0.0086 0.0983
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0147 0.1998
Mycobacterium ulcerans diacylglycerol kinase 0.0021 0.0086 0.0086
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0045 0.0337 0.0357
Schistosoma mansoni hypothetical protein 0.0018 0.0057 0.0023
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2516 0.2956
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0043 0.0005
Plasmodium vivax importin-beta 2, putative 0.0034 0.0219 0.8989
Echinococcus granulosus high affinity choline transporter 1 0.0406 0.4173 0.4933
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0147 0.1998
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0239 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0611 0.0684
Brugia malayi Diacylglycerol kinase protein 2 0.0021 0.0086 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0086 0.0129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0057 0.0077
Echinococcus granulosus sphingosine kinase 1 0.0543 0.5628 0.6669
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0018
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0043 0.0005
Leishmania major importin beta-1 subunit, putative 0.0027 0.0152 0.2066
Echinococcus granulosus Diacylglycerol kinase theta 0.0021 0.0086 0.0058
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0086 0.0057
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0052
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0271 0.0919
Brugia malayi hypothetical protein 0.0021 0.0086 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0448 0.0411
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0057 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0448 0.1074
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0312 0.0327
Schistosoma mansoni hypothetical protein 0.0442 0.4556 0.539
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0086 0.1085
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.068 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0585 0.0652
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0077
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0271 0.0277
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0043 0.0005
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0152 0.0493
Echinococcus granulosus zinc finger protein 0.0025 0.0125 0.0104
Schistosoma mansoni diacylglycerol kinase theta 0.0021 0.0086 0.0058
Loa Loa (eye worm) hypothetical protein 0.0406 0.4173 0.7408
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0294
Schistosoma mansoni hypothetical protein 0.0179 0.1764 0.2059
Brugia malayi MH2 domain containing protein 0.013 0.1242 0.2977
Leishmania major cytochrome p450-like protein 0.0017 0.0038 0.0361
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0075 0.0044
Schistosoma mansoni diacylglycerol kinase theta 0.0021 0.0086 0.0058
Loa Loa (eye worm) diacylglycerol kinase 2 0.0021 0.0086 0.0129
Echinococcus granulosus dnaJ subfamily B 0.0442 0.4556 0.539
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0271 0.385
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0336 0.0355
Brugia malayi Bromodomain containing protein 0.009 0.0818 0.1961
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0362 0.0867
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0611 0.0684

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.