Detailed information for compound 1243236

Basic information

Technical information
  • TDR Targets ID: 1243236
  • Name: MLS000034211
  • MW: 368.453 | Formula: C19H20N4O2S
  • H donors: 1 H acceptors: 3 LogP: 2.71 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C31CCN(CC3)C(=O)C)sc1c2c(C)cc(n1)C
  • InChi: 1S/C19H20N4O2S/c1-10-8-11(2)22-18-14(10)15-16(26-18)19(13(9-20)17(21)25-15)4-6-23(7-5-19)12(3)24/h8H,4-7,21H2,1-3H3
  • InChiKey: PYEGXOYTEVCVJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000014553

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0131 0.0769 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0067 0.0206
Leishmania major GTP-binding protein, putative 0.0022 0.0067 0.0206
Schistosoma mansoni hypothetical protein 0.0024 0.0084 0.0182
Schistosoma mansoni endoplasmin 0.0052 0.0261 0.0695
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0052 0.0262 0.1077
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0161 0.0466
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0248 0.1914
Schistosoma mansoni survival motor neuron protein 0.0052 0.0258 0.0688
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0081 0.0457
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0031 0.0056
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0462 0.1277
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0133 0.0945
Brugia malayi PHD-finger family protein 0.0016 0.0029 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.006 0.0176
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Schistosoma mansoni heat shock protein 0.0035 0.0149 0.037
Schistosoma mansoni cpg binding protein 0.0098 0.0557 0.1556
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0007
Loa Loa (eye worm) histone methyltransferase 0.003 0.012 0.0098
Schistosoma mansoni hypothetical protein 0.0032 0.0133 0.0323
Echinococcus granulosus geminin 0.0552 0.3467 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.006 0.0509
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.008 0.0479
Toxoplasma gondii exonuclease III APE 0.0021 0.006 0.0325
Plasmodium falciparum cysteine protease ATG4, putative 0.0052 0.0262 0.2038
Mycobacterium ulcerans heat shock protein 90 0.0049 0.024 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0049 0.024 1
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0067 0.0207
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0024 0.0008
Brugia malayi hypothetical protein 0.0149 0.0885 0.2898
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0024 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0221 0.1685
Entamoeba histolytica peptidase, C54 family 0.0134 0.0786 0.314
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0162 0.0628
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0849 0.2402
Plasmodium falciparum phd finger protein, putative 0.0032 0.0133 0.0929
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.01 0.057 0.1841
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0022 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0221 0.0822
Schistosoma mansoni inositol monophosphatase 0.0036 0.0162 0.0407
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0134 0.0786 0.3414
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.1016 0.3338
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Echinococcus granulosus snurportin 1 0.0315 0.195 0.5597
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0134 0.0786 0.4426
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0081 0.0269
Loa Loa (eye worm) hypothetical protein 0.0054 0.0277 0.0255
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0112 0.0647 0.2571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0172 0.0436
Plasmodium vivax heat shock protein 90, putative 0.0035 0.0149 0.1068
Echinococcus granulosus endoplasmin 0.0049 0.024 0.0633
Toxoplasma gondii histone lysine methyltransferase SET1 0.0182 0.1092 0.9151
Brugia malayi jmjC domain containing protein 0.0105 0.06 0.194
Brugia malayi jmjC domain containing protein 0.0044 0.021 0.063
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0067 0.0382
Loa Loa (eye worm) hypothetical protein 0.01 0.0567 0.0546
Schistosoma mansoni heat shock protein 0.0052 0.0261 0.0695
Echinococcus granulosus Peptidase C54 0.0134 0.0786 0.2216
Schistosoma mansoni hypothetical protein 0.0151 0.0895 0.2536
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.06 0.1676
Echinococcus granulosus bloom syndrome protein 0.0027 0.0102 0.0232
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0052 0.0262 0.2052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0375 0.1186
Trypanosoma brucei heat shock protein 84, putative 0.0035 0.0149 0.0572
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0067 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0161 0.0139
Leishmania major cytochrome p450-like protein 0.0015 0.0022 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0895 0.0875
Loa Loa (eye worm) hypothetical protein 0.0137 0.0807 0.0786
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0063 0.0353
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0024 0.0006
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Brugia malayi Doublecortin family protein 0.0024 0.008 0.0194
Brugia malayi Pre-SET motif family protein 0.0253 0.1552 0.5139
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0479 0.2999 0.2982
Schistosoma mansoni cpg binding protein 0.0098 0.0557 0.1556
Loa Loa (eye worm) heat shock protein 90 0.0052 0.0261 0.0239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.006 0.011
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0117 0.081
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.006 0.034
Loa Loa (eye worm) TAR-binding protein 0.0144 0.0849 0.0829
Plasmodium vivax heat shock protein 86, putative 0.0052 0.0261 0.2027
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0024 0.0006
Schistosoma mansoni loxhd1 0.0024 0.008 0.017
Entamoeba histolytica peptidase, C54 family 0.0052 0.0262 0.0991
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.195 0.1932
Leishmania major sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0523 0.0502
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0161 0.0403
Trichomonas vaginalis endoplasmin, putative 0.0038 0.0169 0.0955
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0277 0.2162
Schistosoma mansoni polycystin 1-related 0.0024 0.008 0.017
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0024 0.0008
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0213 0.0554
Trypanosoma brucei phospholipase A1, putative 0.0364 0.2261 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0063 0.0353
Brugia malayi RNA binding protein 0.0144 0.0849 0.2777
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.006 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Trypanosoma cruzi lanosterol synthase, putative 0.0197 0.1193 0.5232
Echinococcus multilocularis heat shock protein 90 0.0052 0.0261 0.0692
Schistosoma mansoni rab6-interacting 0.0024 0.008 0.017
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0162 0.0404
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0169 0.0955
Schistosoma mansoni cytochrome P450 0.0015 0.0022 0.0002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0162 0.6384
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0161 0.0403
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.066
Trypanosoma brucei Sterol methyltransferase, putative 0.0206 0.1247 0.5471
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0134 0.0786 0.4426
Brugia malayi Peptidase family C54 containing protein 0.0134 0.0786 0.2564
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Brugia malayi Phospholipase A2 family protein 0.041 0.2558 0.8517
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0394 0.2457 1
Schistosoma mansoni hypothetical protein 0.007 0.0375 0.1027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.006 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0095
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0111
Plasmodium vivax endoplasmin, putative 0.0052 0.0261 0.2027
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0172 0.0434
Plasmodium falciparum heat shock protein 90, putative 0.0197 0.1191 1
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0021 0.0118
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0137 0.526
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Brugia malayi Latrophilin receptor protein 2 0.007 0.0375 0.1186
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0133 0.0945
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0044 0.0213 0.0553
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.1016 0.2885
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.008 0.0168
Onchocerca volvulus 0.0052 0.0258 0.0235
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0375 0.1025
Trypanosoma cruzi lanosterol synthase, putative 0.0197 0.1193 0.5232
Schistosoma mansoni hypothetical protein 0.0052 0.0258 0.0688
Loa Loa (eye worm) doublecortin family protein 0.0024 0.008 0.0058
Trichomonas vaginalis set domain proteins, putative 0.0288 0.1775 1
Schistosoma mansoni vesicular acetylcholine transporter 0.0479 0.2999 0.8643
Echinococcus granulosus heat shock protein 90 0.0052 0.0261 0.0692
Loa Loa (eye worm) hypothetical protein 0.0134 0.0786 0.0765
Echinococcus granulosus serotonin transporter 0.0015 0.0024 0.0006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0067 0.015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0375 0.1025
Echinococcus multilocularis vesicular acetylcholine transporter 0.0479 0.2999 0.8643
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.0895 0.2932
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0465
Echinococcus granulosus heat shock protein 0.0052 0.0261 0.0692
Toxoplasma gondii hypothetical protein 0.0015 0.0024 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0375 0.1025
Onchocerca volvulus 0.0288 0.1775 0.1755
Entamoeba histolytica peptidase, C54 family 0.0052 0.0262 0.0991
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0221 0.067
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0213 0.0636
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0084 0.0179
Brugia malayi RNA recognition motif domain containing protein 0.0144 0.0849 0.2777
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0084 0.0179
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.006 0.011
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0028 0.0016
Brugia malayi hypothetical protein 0.0035 0.0153 0.0438
Loa Loa (eye worm) hypothetical protein 0.0253 0.155 0.1531
Loa Loa (eye worm) hypothetical protein 0.01 0.057 0.0549
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0024 0.0002
Entamoeba histolytica peptidase, C54 family 0.0052 0.0262 0.0991
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0031 0.0056
Brugia malayi hypothetical protein 0.0054 0.0277 0.0854
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.012 0.0285
Echinococcus multilocularis dnaJ subfamily B 0.0479 0.2999 0.8643
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0067 0.0365
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Onchocerca volvulus 0.0364 0.2261 0.2242
Plasmodium vivax heat shock protein, putative 0.0197 0.1191 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0063 0.0353
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0002
Schistosoma mansoni autophagin-1 (C54 family) 0.0134 0.0786 0.2218
Entamoeba histolytica Ran family GTPase 0.0022 0.0067 0.0189
Loa Loa (eye worm) RecQ helicase 0.0027 0.0102 0.008
Echinococcus granulosus RUN 0.0024 0.008 0.0168
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Schistosoma mansoni hypothetical protein 0.007 0.0375 0.1027
Loa Loa (eye worm) inositol-1 0.0036 0.0162 0.014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0067 0.0045
Brugia malayi CXXC zinc finger family protein 0.0093 0.0523 0.1683
Echinococcus granulosus cysteine protease atg4b 0.0134 0.0786 0.2216
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.006 0.0308
Schistosoma mansoni lipoxygenase 0.0024 0.008 0.017
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.066
Leishmania major cytochrome p450-like protein 0.0015 0.0022 0.0007
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0162 0.5622
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0172 0.0434
Entamoeba histolytica hypothetical protein 0.0112 0.0647 0.2571
Loa Loa (eye worm) hypothetical protein 0.0149 0.0885 0.0865
Schistosoma mansoni endoplasmin 0.0052 0.0261 0.0695
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.021 0.0547
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0261 0.1072
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0052 0.0262 0.1077
Schistosoma mansoni hypothetical protein 0.007 0.0375 0.1027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0172 0.0436
Brugia malayi Endoplasmin precursor 0.0052 0.0261 0.0801
Trichomonas vaginalis ran, putative 0.0022 0.0067 0.0377
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0049 0.024 0.2921
Giardia lamblia PHD finger protein 15 0.0032 0.0133 0.0302
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.012 0.0285
Brugia malayi Importin beta-1 subunit 0.003 0.0117 0.0318
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0261 0.0985
Onchocerca volvulus 0.0093 0.0523 0.05
Echinococcus multilocularis heat shock protein 0.0052 0.0261 0.0692
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0052 0.0262 0.1077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0182 0.0462
Plasmodium falciparum importin beta, putative 0.003 0.0117 0.0794
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0172 0.0434
Onchocerca volvulus Phospholipase A2 homolog 0.1571 1 1
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0849 0.2402
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0022 0.0007
Schistosoma mansoni ran 0.0022 0.0067 0.0132
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.021 0.0545
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0248 0.1928
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0022 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.006 0.0176
Loa Loa (eye worm) heat shock protein 75 0.0035 0.0149 0.0127
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0162 0.1191
Brugia malayi hypothetical protein 0.0024 0.008 0.0194
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0137 0.1537
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0024 0.0006
Schistosoma mansoni hypothetical protein 0.0479 0.2999 0.8643
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.1552 0.1533
Brugia malayi Hsp90 protein 0.0035 0.0149 0.0425
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0084 0.0179
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.008 0.0479
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0277 0.2162
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0022 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0182 0.0465
Brugia malayi hypothetical protein 0.0024 0.008 0.0194
Brugia malayi vesicular acetylcholine transporter unc-17 0.0479 0.2999 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0258 0.0793
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0063 0.0353
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0035 0.0149 0.0368
Schistosoma mansoni hypothetical protein 0.0315 0.195 0.5598
Echinococcus granulosus heat shock protein 90 0.0044 0.0213 0.0553
Brugia malayi PHD-finger family protein 0.0032 0.0133 0.0371
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0024 0.0006
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.066
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0024 0.0008
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0133 0.0111
Echinococcus granulosus vesicular acetylcholine transporter 0.0479 0.2999 0.8643
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0065 0.0128
Trichomonas vaginalis heat shock protein, putative 0.0049 0.024 0.1354
Trypanosoma cruzi phospholipase A1, putative 0.0364 0.2261 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0117 0.0275
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0024 0.0006
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0134 0.0786 0.4426
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.006 0.0128
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0364 0.2261 0.2244
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0067 0.0365
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Leishmania major heat shock protein, putative 0.0035 0.0149 0.0572
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.1343 0.4437
Leishmania major phospholipase A1, putative 0.0364 0.2261 1
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0157 0.0135
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0167 0.0998 0.436
Schistosoma mansoni hypothetical protein 0.0552 0.3467 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0084 0.0179
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0213 0.1199
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0185 0.0547
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0162 0.0628
Trichomonas vaginalis heat shock protein, putative 0.0049 0.024 0.1354
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0161 0.0626
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0849 0.2402
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.008 0.0168
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.006 0.0176
Echinococcus multilocularis endoplasmin 0.0049 0.024 0.0633
Schistosoma mansoni importin beta-1 0.003 0.0117 0.0277
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0161 0.1187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Brugia malayi TAR-binding protein 0.0144 0.0849 0.2777
Toxoplasma gondii heat shock protein 75, putative 0.0035 0.0149 0.1084
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0133 0.0321
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0277 0.1141
Plasmodium falciparum endoplasmin, putative 0.0038 0.0169 0.1244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0172 0.0436
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0248 0.0654
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0161 0.0626
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0261 0.1072
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0107 0.0615 0.2654
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0161 0.0403
Schistosoma mansoni hypothetical protein 0.007 0.0375 0.1027
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.0986 0.2796
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.006 0.034
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0134 0.0786 0.4426
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0277 0.1141
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0102 0.0232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0024 0.0006
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Entamoeba histolytica hypothetical protein 0.004 0.0182 0.066
Giardia lamblia DNA repair protein RAD52 0.0394 0.2457 1
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Loa Loa (eye worm) RNA binding protein 0.0144 0.0849 0.0829
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.006 0.1741
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0161 0.0403
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0248 0.1395
Brugia malayi RNA, U transporter 1 0.0084 0.0466 0.1491
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0017
Loa Loa (eye worm) endoplasmin 0.0052 0.0261 0.0239
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0035 0.0149 0.0526
Leishmania major lanosterol synthase, putative 0.0197 0.1193 0.5232
Echinococcus multilocularis Peptidase C54 0.0134 0.0786 0.2216
Trypanosoma cruzi phospholipase A1, putative 0.0364 0.2261 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0162 0.0407
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0052 0.0262 0.1077
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0102 0.0576
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Onchocerca volvulus Phospholipase A2 homolog 0.041 0.2558 0.254
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0375 0.0354
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0261 0.1072
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0024 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0261 0.147
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0161 0.1172
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0134 0.0786 0.2218
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.008 0.0168
Trypanosoma cruzi heat shock protein, putative 0.0035 0.0149 0.0572
Schistosoma mansoni hypothetical protein 0.0024 0.008 0.017
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0024 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0117 0.0429
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0162 0.0628
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0567 0.1584
Brugia malayi Inositol-1 0.0036 0.0162 0.0468
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0084 0.0179
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.155 0.4434
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0167 0.0998 0.436
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0024 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0151 0.0376
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Schistosoma mansoni hypothetical protein 0.0552 0.3467 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0133 0.0323
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0024 0.0008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0063 0.0353
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0261 0.0837
Brugia malayi heat shock protein 90 0.0052 0.0261 0.0801
Echinococcus granulosus cpg binding protein 0.0098 0.0557 0.1553
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0198 0.12 0.3421
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0007
Schistosoma mansoni cpg binding protein 0.0093 0.0523 0.1457
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0084 0.0179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0375 0.1025
Leishmania major hypothetical protein, conserved 0.0054 0.0277 0.1141
Echinococcus multilocularis RUN 0.0024 0.008 0.0168
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0162 0.091
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0277 0.2175
Entamoeba histolytica peptidase, C54 family 0.0052 0.0262 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0162 0.0628
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0144 0.0849 0.0829
Loa Loa (eye worm) hypothetical protein 0.0038 0.0172 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0277 0.2162
Echinococcus granulosus peregrin 0.0036 0.0159 0.0398
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.006 0.0176
Toxoplasma gondii heat shock protein HSP90 0.0052 0.0261 0.2041
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0161 0.1187
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0102 0.0576
Schistosoma mansoni rab6-interacting 0.0024 0.008 0.017
Onchocerca volvulus 0.0024 0.008 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0058
Brugia malayi hypothetical protein 0.0253 0.155 0.513
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.0354
Brugia malayi hypothetical protein 0.0015 0.0024 0.0007
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0067 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.1343 0.4437
Entamoeba histolytica hypothetical protein 0.0024 0.0081 0.0248
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0248 0.1395
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0063 0.0353
Plasmodium vivax SET domain protein, putative 0.0038 0.0172 0.1263
Brugia malayi hypothetical protein 0.004 0.0182 0.0535
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.006 0.1664
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.1343 0.1324
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0024 0.0002
Echinococcus multilocularis cpg binding protein 0.0098 0.0557 0.1553
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0176 0.0446
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Echinococcus granulosus tar DNA binding protein 0.0144 0.0849 0.2401
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0162 0.0578
Echinococcus multilocularis geminin 0.0552 0.3467 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0067 0.0028
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0479 0.2999 0.2984
Trypanosoma cruzi Heat shock protein 83, putative 0.0052 0.0261 0.1072
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0134 0.0786 0.3414
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0024 0.0008
Loa Loa (eye worm) acetyltransferase 0.017 0.1016 0.0996
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0261 0.1072
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0351 0.033
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0355 0.0966
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0028 0.0016
Schistosoma mansoni ap endonuclease 0.0021 0.006 0.0113
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0134 0.0786 0.4426
Onchocerca volvulus 0.0364 0.2261 0.2242
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0022 0.0007
Echinococcus multilocularis tar DNA binding protein 0.0144 0.0849 0.2401
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0277 0.1141
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0134 0.0786 0.3414
Loa Loa (eye worm) hypothetical protein 0.01 0.0567 0.0546
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0161 0.1859
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0121 0.0831
Trichomonas vaginalis heat shock protein, putative 0.003 0.0121 0.0684
Leishmania major cytochrome p450-like protein 0.0015 0.0022 0.0007
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0024 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0058
Trypanosoma brucei Heat shock protein 83, putative 0.0052 0.0261 0.1072
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0049 0.024 0.098
Onchocerca volvulus 0.0149 0.0885 0.0863
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.006 0.0162
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0049 0.024 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.008 0.0168
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.008 0.0168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0161 0.0626
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0044 0.0187
Schistosoma mansoni lipoxygenase 0.0067 0.0355 0.0968
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0081 0.0485
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0133 0.0321
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0117 0.0429
Brugia malayi Pre-SET motif family protein 0.0038 0.0172 0.0502
Leishmania major sterol 24-c-methyltransferase, putative 0.0206 0.1247 0.5471
Loa Loa (eye worm) hypothetical protein 0.0055 0.0279 0.0258
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0213 0.0857
Brugia malayi Cytochrome P450 family protein 0.0036 0.0157 0.0453
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0133 0.0929
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0035 0.0149 0.0368
Plasmodium falciparum heat shock protein 90 0.0052 0.0261 0.2027
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0102 0.0268
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0161 0.1172
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.0567 0.1582
Schistosoma mansoni heat shock protein 0.0052 0.0261 0.0695
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.06 0.1676
Schistosoma mansoni ap endonuclease 0.0021 0.006 0.0113
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0024 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0162 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0081 0.0457
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.008 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0063 0.0353
Onchocerca volvulus 0.0024 0.008 0.0056
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0567 0.1584
Treponema pallidum heat shock protein 90 0.0049 0.024 1
Trichomonas vaginalis helicase, putative 0.0021 0.0063 0.0353
Echinococcus multilocularis heat shock protein 90 0.0044 0.0213 0.0553
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0024 0.0006
Echinococcus granulosus GPCR family 2 0.007 0.0375 0.1025
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0022 0.0007
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0849 0.2402
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0161 0.0626
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0067 0.013
Loa Loa (eye worm) hypothetical protein 0.041 0.2558 0.2541
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0355 0.0966
Brugia malayi Bromodomain containing protein 0.0036 0.0159 0.0461
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0022 0.0007
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0024 0.0006
Onchocerca volvulus Alhambra homolog 0.0032 0.0133 0.0109
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.0567 0.1584
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0261 0.1072
Echinococcus multilocularis snurportin 1 0.0315 0.195 0.5597
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0162 0.091
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0024 0.0002
Leishmania major heat shock protein 83-1 0.0052 0.0261 0.1072
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0213 0.0554
Echinococcus granulosus importin subunit beta 1 0.003 0.0117 0.0275
Schistosoma mansoni ran 0.0022 0.0067 0.0132
Trypanosoma brucei heat shock protein, putative 0.0052 0.0261 0.1072
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0081 0.0457
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0.0024 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0063 0.0353
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.0567 0.1582
Echinococcus multilocularis serotonin transporter 0.0015 0.0024 0.0006
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0261 0.0985
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0213 0.0857
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0849 0.2402
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.021 0.0188
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0261 0.1072
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0067 0.0206
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.015 0.0371
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0024 0.0007
Trypanosoma brucei lanosterol synthase 0.0197 0.1193 0.5232
Giardia lamblia Grp94/Hsp90 0.0049 0.024 0.0751
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0172 0.0436
Onchocerca volvulus 0.0038 0.0172 0.0148
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0161 0.0405
Toxoplasma gondii Hsp90 domain-containing protein 0.0197 0.1191 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0172 0.1278
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0022 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.021 0.0547
Brugia malayi isocitrate dehydrogenase 0.0036 0.0161 0.0466
Toxoplasma gondii heat shock protein 90, putative 0.0052 0.0261 0.2041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0161 0.0403
Echinococcus multilocularis GPCR, family 2 0.007 0.0375 0.1025
Onchocerca volvulus 0.0364 0.2261 0.2242
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.1016 0.2887
Toxoplasma gondii hypothetical protein 0.0015 0.0024 0.0017
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0248 0.1928
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0364 0.2261 0.752
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0161 0.0626
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0161 0.0403
Leishmania major importin beta-1 subunit, putative 0.0024 0.0081 0.0269
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0046 0.0182
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0134 0.0786 0.2218
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0182 0.0462
Plasmodium vivax importin-beta 2, putative 0.003 0.0117 0.0794
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.155 0.4434
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0162 0.091
Echinococcus multilocularis cysteine protease atg4b 0.0134 0.0786 0.2216
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0063 0.0353
Echinococcus granulosus dnaJ subfamily B 0.0479 0.2999 0.8643
Echinococcus multilocularis peregrin 0.0036 0.0159 0.0398
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0024 0.0006
Loa Loa (eye worm) hypothetical protein 0.0221 0.1343 0.1324
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0035 0.0149 0.0125

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1299 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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