Detailed information for compound 1250427

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.44 | Formula: C21H24N4O3
  • H donors: 1 H acceptors: 2 LogP: 2.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1noc2c1cccc2
  • InChi: 1S/C21H24N4O3/c1-27-17-6-4-5-16(15-17)21(26)22-9-10-24-11-13-25(14-12-24)20-18-7-2-3-8-19(18)28-23-20/h2-8,15H,9-14H2,1H3,(H,22,26)
  • InChiKey: CKPAPDLVEHXFQY-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D4 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D4 receptor   387 aa 373 aa 28.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Dopamine D4 receptor   387 aa 347 aa 23.3 %
Loa Loa (eye worm) hypothetical protein Dopamine D4 receptor   387 aa 368 aa 26.9 %
Echinococcus granulosus thyrotropin releasing hormone receptor Dopamine D4 receptor   387 aa 356 aa 23.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Dopamine D4 receptor   387 aa 356 aa 26.4 %
Schistosoma mansoni amine GPCR Dopamine D4 receptor   387 aa 394 aa 26.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D4 receptor   387 aa 350 aa 31.4 %
Onchocerca volvulus Dopamine D4 receptor   387 aa 315 aa 22.5 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Dopamine D4 receptor   387 aa 371 aa 27.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Dopamine D4 receptor   387 aa 349 aa 31.2 %
Echinococcus granulosus g protein coupled receptor Dopamine D4 receptor   387 aa 342 aa 21.3 %
Onchocerca volvulus Dopamine D4 receptor   387 aa 346 aa 34.1 %
Onchocerca volvulus Dopamine D4 receptor   387 aa 391 aa 30.7 %
Brugia malayi sulfakinin receptor protein Dopamine D4 receptor   387 aa 316 aa 22.8 %
Loa Loa (eye worm) hypothetical protein Dopamine D4 receptor   387 aa 355 aa 22.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D4 receptor   387 aa 378 aa 26.5 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Dopamine D4 receptor   387 aa 373 aa 29.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus protein quaking 0.0053 0.0244 0.0526
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0047 0.013
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.0043 0.0117
Brugia malayi Muscleblind-like protein 0.046 0.2643 0.7283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.0691 0.0691
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.1851 0.5099
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0168 0.0479
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0174 0.0174
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0043 0.0092
Loa Loa (eye worm) RNA binding protein 0.0065 0.0315 0.0867
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0075 0.0542
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0195 0.042
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0022 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0246 0.138 1
Brugia malayi Pre-SET motif family protein 0.0216 0.1206 0.3323
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0217
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0047 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0047 0.013
Echinococcus granulosus peregrin 0.0015 0.0018 0.0039
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0112 0.0756
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.025 0.0688
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.022 0.0475
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0315 0.0315
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0047 0.0047
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0699
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0471 0.1016
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0077 0.0556
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.031 0.7134
Echinococcus multilocularis protein quaking 0.0053 0.0244 0.0244
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0351 0.0966
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.0047
Echinococcus multilocularis microtubule associated protein 2 0.0743 0.4318 0.4318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0047 0.013
Onchocerca volvulus 0.0049 0.022 0.0629
Echinococcus granulosus microtubule associated protein 2 0.0743 0.4318 0.9315
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0047 0.0102
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0047 0.0047
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0218 0.1218 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0047 0.0047
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0063 0.0063
Plasmodium falciparum telomerase reverse transcriptase 0.0165 0.0905 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0091 0.1007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0377 0.0813
Trypanosoma cruzi ISWI complex protein 0.0032 0.0121 0.083
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0047 0.013
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0075 0.0955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0047 0.013
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0091 0.0581
Toxoplasma gondii RNA-directed DNA polymerase 0.0165 0.0905 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0419 0.4628
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.0143 0.0143
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0825 0.1781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0047 0.0047
Echinococcus multilocularis geminin 0.0339 0.1931 0.1931
Loa Loa (eye worm) hypothetical protein 0.004 0.0168 0.0462
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0419 0.0903
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0022 0.0022
Echinococcus granulosus snurportin 1 0.0325 0.1851 0.3993
Onchocerca volvulus 0.0056 0.0261 0.0747
Brugia malayi hypothetical protein 0.0027 0.0091 0.0251
Echinococcus granulosus importin subunit beta 1 0.003 0.0111 0.0239
Schistosoma mansoni SET domain protein 0.002 0.0052 0.0111
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.0043 0.0092
Echinococcus granulosus expressed protein 0.0033 0.0123 0.0266
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0022 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Leishmania major importin beta-1 subunit, putative 0.0025 0.0077 0.0461
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0047 0.0047
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.022 0.0629
Onchocerca volvulus 0.0024 0.0075 0.0213
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0042 0.071
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Schistosoma mansoni microtubule-associated protein tau 0.0743 0.4318 0.9315
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0557 0.0557
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0047 0.013
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0199 0.043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0105
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0337 0.0728
Loa Loa (eye worm) hypothetical protein 0.0477 0.2747 0.7567
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Schistosoma mansoni cpg binding protein 0.0063 0.0304 0.0655
Trypanosoma brucei unspecified product 0.0019 0.0042 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0047 0.0102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.0022
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0165 0.0905 0.738
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0315 0.0867
Brugia malayi Bromodomain containing protein 0.0161 0.0881 0.2427
Plasmodium vivax SET domain protein, putative 0.0033 0.0126 0.1389
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.031 0.031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0091
Echinococcus multilocularis cpg binding protein 0.0063 0.0304 0.0304
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0042 0.0091
Mycobacterium ulcerans hypothetical protein 0.0024 0.0075 0.0955
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0091 0.1007
Schistosoma mansoni ran 0.0022 0.0063 0.0136
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0099 0.1094
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0566 0.1222
Schistosoma mansoni zinc finger protein 0.0044 0.0193 0.0416
Echinococcus multilocularis importin subunit beta 1 0.003 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0477 0.2747 0.7567
Echinococcus granulosus geminin 0.0339 0.1931 0.4165
Schistosoma mansoni hypothetical protein 0.0104 0.0546 0.1177
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0599 0.6626
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.2481
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0353 0.2558
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0119 0.1313
Echinococcus multilocularis lamin 0.0054 0.025 0.025
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0091 0.1007
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0546 0.1503
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0315 0.0679
Echinococcus granulosus expressed conserved protein 0.01 0.0519 0.1119
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.026 0.0716
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Schistosoma mansoni patched 1 0.0046 0.0199 0.043
Brugia malayi Heterochromatin protein 1 0.0072 0.0353 0.0973
Brugia malayi hypothetical protein 0.0035 0.0138 0.0381
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.031 0.2408
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.026 0.026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0374
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.026 0.0561
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.2481
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.022 0.022
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0081 0.0407 0.1122
Trypanosoma brucei ISWI complex protein 0.0032 0.0121 0.0936
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0123 0.034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0351 0.2749
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0042 0.0305
Echinococcus granulosus zinc finger protein 0.0044 0.0193 0.0416
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0009 0.002
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0419 0.0419
Schistosoma mansoni lozenge 0.006 0.0284 0.0613
Loa Loa (eye worm) hypothetical protein 0.0104 0.0546 0.1503
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.031 0.7134
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0594
Leishmania major hypothetical protein, conserved 0.0027 0.0091 0.0581
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 0.4628
Brugia malayi PHD-finger family protein 0.0056 0.0259 0.0714
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.01
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.0691 0.1491
Brugia malayi TAR-binding protein 0.0065 0.0315 0.0867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0126 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.083 0.2287
Loa Loa (eye worm) hypothetical protein 0.0053 0.0244 0.0672
Echinococcus granulosus GPCR family 2 0.0048 0.0215 0.0465
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0047 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0471 0.1016
Loa Loa (eye worm) hypothetical protein 0.0093 0.0479 0.132
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0604 0.3496 1
Echinococcus multilocularis muscleblind protein 1 0.046 0.2643 0.2643
Loa Loa (eye worm) hypothetical protein 0.0106 0.0557 0.1534
Brugia malayi SET domain containing protein 0.0015 0.0021 0.0057
Echinococcus granulosus cpg binding protein 0.0063 0.0304 0.0655
Echinococcus multilocularis chromobox protein 1 0.0072 0.0353 0.0353
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0022 0.0239
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0143 0.0308
Schistosoma mansoni hypothetical protein 0.0053 0.0244 0.0526
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0218 0.1218 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0215 0.0215
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.015 0.0414
Schistosoma mansoni cpg binding protein 0.0056 0.0261 0.0564
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0218 0.1218 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0419 0.4628
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0075 0.0443
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0351 0.2834
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0321
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0075 0.0542
Echinococcus granulosus dnaJ subfamily B 0.0797 0.4635 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0026 0.0026
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0557 0.1534
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0047 0.0102
Leishmania major GTP-binding protein, putative 0.0022 0.0063 0.0348
Brugia malayi CXXC zinc finger family protein 0.0056 0.0261 0.072
Trypanosoma brucei calpain-like protein, putative 0.0218 0.1218 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0091 0.1007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0105
Echinococcus multilocularis protein patched 0.0046 0.0199 0.0199
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0186 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Schistosoma mansoni hypothetical protein 0.0339 0.1931 0.4165
Schistosoma mansoni thyroid hormone receptor 0.002 0.0047 0.0102
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0315 0.0867
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0075 0.0955
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.022 0.0606
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0075 0.0443
Brugia malayi Pre-SET motif family protein 0.0033 0.0126 0.0346
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0047 0.0102
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0351 0.0966
Echinococcus granulosus hypothetical protein 0.0053 0.0244 0.0526
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0022 0.0239
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0189 0.052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0047 0.013
Echinococcus granulosus lamin dm0 0.0054 0.025 0.0539
Brugia malayi tumor suppressor. 0.0627 0.363 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0044 0.019 0.0409
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0035 0.0251
Echinococcus multilocularis snurportin 1 0.0325 0.1851 0.1851
Schistosoma mansoni rotamase 0.0033 0.0123 0.0266
Echinococcus granulosus dna polymerase kappa 0.0019 0.0042 0.0091
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0042 0.0116
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0038 0.0423
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0374
Brugia malayi CHD4 protein 0.0019 0.0043 0.0117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0042 0.0305
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.022 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0168 0.1214
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0022 0.0116
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0251 0.5116
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0022 0.006
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0075 0.0205
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0075 0.0955
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0174 0.0375
Schistosoma mansoni hypothetical protein 0.0044 0.019 0.0409
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0075 0.0955
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0099 0.0709
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0111 0.0853
Echinococcus granulosus chromobox protein 1 0.0072 0.0353 0.0762
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0471 0.1016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0471 0.1297
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0419 0.0903
Entamoeba histolytica Ran family GTPase 0.0022 0.0063 0.1136
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0218 0.1218 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0026 0.0057
Trypanosoma brucei hypothetical protein 0.0218 0.1218 1
Trypanosoma cruzi ISWI complex protein 0.0032 0.0121 0.083
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0047 0.0102
Schistosoma mansoni hypothetical protein 0.0053 0.0244 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0047 0.013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0077 0.0556
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0075 0.0542
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0825 0.0825
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0205
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0042 0.0116
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0000000075773 0.0000000075773
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0186 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0199 0.1445
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1206 0.3323
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0085 0.0183
Schistosoma mansoni hypothetical protein 0.0797 0.4635 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0645 0.1391
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0047 0.0047
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0348
Toxoplasma gondii hypothetical protein 0.0028 0.0099 0.1094
Loa Loa (eye worm) hypothetical protein 0.0056 0.026 0.0716
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.023 0.0495
Loa Loa (eye worm) hypothetical protein 0.0049 0.022 0.0606
Loa Loa (eye worm) hypothetical protein 0.046 0.2643 0.7283
Trichomonas vaginalis ran, putative 0.0022 0.0063 0.0458
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0042 0.0755
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.2481
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0189 0.1397
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0047 0.0102
Echinococcus multilocularis muscleblind protein 0.046 0.2643 0.2643
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0199 0.055
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Loa Loa (eye worm) hypothetical protein 0.046 0.2643 0.7283
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0047 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0374
Loa Loa (eye worm) hypothetical protein 0.0083 0.0419 0.1153
Schistosoma mansoni chromobox protein 0.0072 0.0353 0.0762
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0111 0.0853
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0233
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.0143 0.0309
Schistosoma mansoni hypothetical protein 0.0032 0.0121 0.0261
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0557 0.1201
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0199 0.043
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0047 0.013
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.031 0.0668
Echinococcus multilocularis zinc finger protein 0.0044 0.0193 0.0193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0215 0.0465
Schistosoma mansoni hypothetical protein 0.0325 0.1851 0.3993
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.083 0.2287
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0337 0.0728
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0022 0.0239
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0047 0.0102
Echinococcus multilocularis expressed protein 0.0033 0.0123 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0218 0.1218 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0047 0.013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.004 0.0291
Echinococcus granulosus tar DNA binding protein 0.0065 0.0315 0.0679
Echinococcus multilocularis dna polymerase eta 0.0044 0.0189 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0315 0.0679
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0165 0.0905 0.738
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0047 0.013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0075 0.0955
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0251
Loa Loa (eye worm) hypothetical protein 0.0152 0.083 0.2287
Brugia malayi Temporarily assigned gene name protein 44 0.0053 0.0244 0.0672
Schistosoma mansoni DNA polymerase eta 0.0044 0.0189 0.0407
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0189 0.1497
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0315 0.0679
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0047 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0075 0.0542
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0042 0.0042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0047 0.0102
Loa Loa (eye worm) hypothetical protein 0.003 0.0111 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0098 0.0713
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0351 0.6296
Onchocerca volvulus 0.0477 0.2747 0.7857
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0008
Schistosoma mansoni phd finger protein 0.0015 0.0018 0.0039
Entamoeba histolytica hypothetical protein 0.0025 0.0077 0.1378
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0138 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0098 0.0713
Brugia malayi mbt repeat family protein 0.0049 0.022 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0047 0.013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0042 0.0285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0026 0.0057
Brugia malayi nuclear hormone receptor 0.002 0.0047 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0187 0.0515
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0315 0.0867
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0199 0.0199
Echinococcus granulosus muscleblind protein 0.046 0.2643 0.5703
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.0022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0042 0.071
Loa Loa (eye worm) intermediate filament protein 0.0054 0.025 0.0688
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0419 0.4628
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0251 0.7951
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0047 0.013
Echinococcus granulosus Chromobox protein 3 0.0012 0.0000000075773 0.000000016347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0337 0.0337
Loa Loa (eye worm) MBCTL1 0.0056 0.026 0.0716
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0315 0.0679
Brugia malayi Importin beta-1 subunit 0.003 0.0111 0.0305
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0199 0.055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0075 0.0542
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0123 0.034
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0111 0.1224
Trypanosoma brucei calpain, putative 0.0218 0.1218 1
Brugia malayi hypothetical protein 0.0018 0.0034 0.0095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0126 0.0126
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0063 0.0136
Onchocerca volvulus 0.0246 0.138 0.3948
Echinococcus granulosus FTZ F1 alpha 0.002 0.0047 0.0102
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.031 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.031 0.0668
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0251 0.0541
Echinococcus multilocularis peregrin 0.0015 0.0018 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.0022
Plasmodium vivax importin-beta 2, putative 0.003 0.0111 0.1224
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0022 0.0239
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.026 0.0561
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0105 0.0227
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0353 0.0973
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0075 0.0542
Echinococcus granulosus dna polymerase eta 0.0044 0.0189 0.0407
Schistosoma mansoni zinc finger protein 0.0032 0.0121 0.0261
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0063 0.0699
Echinococcus multilocularis lamin dm0 0.0054 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0048 0.0215 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0123 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0205
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0075 0.0955
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0126 0.1389
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0075 0.1339
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0091 0.0581
Schistosoma mansoni ran 0.0022 0.0063 0.0136
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0437 0.1203
Loa Loa (eye worm) hypothetical protein 0.0054 0.025 0.0688
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.046
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0353 0.2558
Brugia malayi nuclear receptor NHR-88 0.002 0.0047 0.013
Onchocerca volvulus 0.0031 0.0116 0.0333
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0063 0.0304 0.0655
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0143 0.0308
Brugia malayi RNA binding protein 0.0065 0.0315 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0047 0.013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0038 0.0578
Schistosoma mansoni hypothetical protein 0.0298 0.1688 0.3642
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0557 1
Schistosoma mansoni hypothetical protein 0.0044 0.019 0.0409
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0047 0.0102
Echinococcus granulosus chromobox protein 1 0.0072 0.0353 0.0762
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0075 0.0205
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0218 0.1218 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.107 0.107
Echinococcus multilocularis chromobox protein 1 0.0072 0.0353 0.0353
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0022 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0377 0.0377
Brugia malayi mbt repeat family protein 0.0049 0.022 0.0606
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0075 0.0205
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0075 0.1839
Schistosoma mansoni thyroid hormone receptor 0.002 0.0047 0.0102
Echinococcus multilocularis expressed conserved protein 0.01 0.0519 0.0519
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0138 0.0298
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0143 0.0143
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0215 0.0594
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0143 0.0308
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0215 0.0594
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0026 0.0057
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0119 0.2133
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.107 0.2308
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0171
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0085 0.0085
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0022 0.0116
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.2481
Loa Loa (eye worm) hypothetical protein 0.0044 0.0189 0.052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0047 0.013
Leishmania major hypothetical protein, conserved 0.0032 0.0121 0.083
Schistosoma mansoni hypothetical protein 0.0048 0.0215 0.0465
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.031 0.3423
Echinococcus granulosus lamin 0.0054 0.025 0.0539
Schistosoma mansoni nuclear hormone receptor 0.002 0.0047 0.0102
Schistosoma mansoni lamin 0.0054 0.025 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0047 0.013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0047 0.0102
Schistosoma mansoni hypothetical protein 0.0048 0.0215 0.0465
Schistosoma mansoni importin beta-1 0.003 0.0111 0.0239
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0047 0.0135
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0075 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0291
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.026 0.026
Trichomonas vaginalis helicase, putative 0.0013 0.0006 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0069 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0047 0.013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0047 0.0135
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.022 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0047 0.013
Loa Loa (eye worm) hypothetical protein 0.0149 0.0809 0.2229
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0069 0.0337 0.093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0215 0.0594
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0215 0.0465
Schistosoma mansoni hypothetical protein 0.0048 0.0215 0.0465
Loa Loa (eye worm) hypothetical protein 0.0053 0.0244 0.0672
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0112 0.1239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0471 0.0471
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0091 0.0691
Schistosoma mansoni hypothetical protein 0.0339 0.1931 0.4165
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0047 0.0135
Echinococcus multilocularis Protein lozenge 0.006 0.0284 0.0284
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0047 0.0102
Schistosoma mansoni lamin 0.0054 0.025 0.0539
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.026 0.0561
Brugia malayi Probable ClpP-like protease 0.0083 0.0419 0.1153
Brugia malayi ecdysteroid receptor 0.002 0.0047 0.013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0046 0.0046
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0251 0.0251
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0042 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0205
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0075 0.1339
Loa Loa (eye worm) hypothetical protein 0.0056 0.026 0.0716
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0261 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0119 0.0812
Onchocerca volvulus 0.002 0.0047 0.0135
Brugia malayi Telomerase reverse transcriptase 0.0439 0.2522 0.6948
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0077 0.0461
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0077 0.0556
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0063 0.0699
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Echinococcus multilocularis protein dispatched 1 0.0052 0.0237 0.0237
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.031 0.7134
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0351 0.2749
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0171
Schistosoma mansoni chromobox protein 0.0072 0.0353 0.0762
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0075 0.1339
Onchocerca volvulus 0.0054 0.025 0.0714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0075 0.1839
Brugia malayi hypothetical protein 0.0053 0.0244 0.0672
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0042
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 0.5
Onchocerca volvulus 0.0045 0.0195 0.0557
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0351 0.2749
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0215 0.0215
Brugia malayi CHE-14 protein 0.0046 0.0199 0.055
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0351 0.0351
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0047 0.013
Schistosoma mansoni bromodomain containing protein 0.0012 0.0003 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.025 0.0688
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0003 0.0003
Leishmania major DNA polymerase kappa, putative 0.0019 0.0042 0.0171
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0102 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0047 0.013
Trichomonas vaginalis rotamase, putative 0.0032 0.0119 0.086
Onchocerca volvulus 0.0054 0.025 0.0714
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 1
Brugia malayi chromobox protein homolog 3 0.004 0.0168 0.0462
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0042 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0471 0.1016
Plasmodium falciparum importin beta, putative 0.003 0.0111 0.1224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0047 0.013
Leishmania major DNA polymerase eta, putative 0.0044 0.0189 0.1397
Schistosoma mansoni hypothetical protein 0.0035 0.0138 0.0298
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0351 0.0756
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0042 0.0171
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0047 0.0102
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0047 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0026 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0046 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0471 0.1016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0075 0.0542
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0471 0.0471
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.023 0.0495
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0099 0.1094
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0119 0.0812
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.022 0.0475
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0044 0.019 0.0409
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Schistosoma mansoni hypothetical protein 0.0043 0.0187 0.0404
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0218 0.1218 1
Giardia lamblia Telomerase catalytic subunit 0.0165 0.0905 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0186 0.1344
Brugia malayi intermediate filament protein 0.0054 0.025 0.0688
Echinococcus multilocularis dnaJ subfamily B 0.0797 0.4635 0.4635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0218 0.1218 1
Onchocerca volvulus 0.0012 0.0000000075773 0.000000021676
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0042 0.0285
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0047 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0315 0.0679
Brugia malayi hypothetical protein 0.0477 0.2747 0.7567
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0119 0.0812
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.083 0.2287
Brugia malayi RNA, U transporter 1 0.0087 0.0442 0.1219
Echinococcus multilocularis musashi 0.0054 0.025 0.025
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0047 0.013
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0075 0.0955
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0075 0.0542
Schistosoma mansoni coup transcription factor 0.002 0.0047 0.0102
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0047 0.0102
Leishmania major DNA polymerase eta, putative 0.0031 0.0112 0.0756
Schistosoma mansoni bromodomain containing protein 0.0136 0.0735 0.1587
Schistosoma mansoni SET domain protein 0.0036 0.0143 0.0309
Loa Loa (eye worm) histone methyltransferase 0.002 0.0046 0.0128
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0251 0.7951
Schistosoma mansoni intermediate filament proteins 0.0054 0.025 0.0539
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0471 0.1297
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.022 0.0475
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0105
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.0043 0.0043
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0246
Loa Loa (eye worm) tumor suppressor 0.0627 0.363 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0102 0.028
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0119 0.0919
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0038 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0168 0.1214
Loa Loa (eye worm) runx1 0.006 0.0284 0.0783
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0217
Plasmodium vivax telomerase reverse transcriptase, putative 0.0165 0.0905 1
Trypanosoma brucei telomerase reverse transcriptase 0.0165 0.0905 0.7411
Echinococcus granulosus intermediate filament protein 0.0054 0.025 0.0539
Brugia malayi Bromodomain containing protein 0.0081 0.0406 0.112
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0419 1
Trichomonas vaginalis rotamase, putative 0.0033 0.0123 0.0893
Brugia malayi steroid hormone receptor 0.002 0.0047 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0337 0.0728
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0047 0.013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0042 0.01
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0351 0.0756
Brugia malayi isocitrate dehydrogenase 0.0015 0.0022 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0047 0.0102
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.031 0.0668
Leishmania major telomerase reverse transcriptase, putative 0.0165 0.0905 0.738

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 13 % Displacement of [3H](+)-pentazocine from human sigma 1 receptor expressed in MCF7 cells at 1 uM after 180 mins by scintillation counting ChEMBL. 20873719
Activity (binding) = 84 % Displacement of [3H]MSP from rat dopamine D2L receptor expressed in HEK293 cells at 1 uM after 90 mins by scintillation counting ChEMBL. 20873719
Ki (binding) = 1.93 nM Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation counting ChEMBL. 20873719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.