Detailed information for compound 1255494

Basic information

Technical information
  • TDR Targets ID: 1255494
  • Name: 3-(3,5-dimethylphenyl)-1-(2,6-dimethylpiperid in-1-yl)urea
  • MW: 275.389 | Formula: C16H25N3O
  • H donors: 2 H acceptors: 1 LogP: 3.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(C)cc(c1)C)NN1C(C)CCCC1C
  • InChi: 1S/C16H25N3O/c1-11-8-12(2)10-15(9-11)17-16(20)18-19-13(3)6-5-7-14(19)4/h8-10,13-14H,5-7H2,1-4H3,(H2,17,18,20)
  • InChiKey: QLUZLDYOFZZZSH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(3,5-dimethylphenyl)-1-(2,6-dimethyl-1-piperidyl)urea
  • 3-(3,5-dimethylphenyl)-1-(2,6-dimethyl-1-piperidinyl)urea
  • MLS000660706
  • N-(3,5-dimethylphenyl)-N'-(2,6-dimethylpiperidin-1-yl)urea
  • SMR000310225

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0182 0.0175
Onchocerca volvulus 0.0268 0.5729 0.5726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0044 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0581 0.272
Schistosoma mansoni netrin receptor unc5 0.0014 0.0229 0.0222
Brugia malayi cytochrome P450 0.0031 0.0581 0.0574
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0581 0.272
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0581 0.0574
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0044 0.0037
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0581 0.272
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0182 0.0175
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.1153 0.1147
Schistosoma mansoni loxhd1 0.0021 0.037 0.0363
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.12 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1153 0.1147
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1576 0.157
Brugia malayi Cytochrome P450 family protein 0.0031 0.0581 0.0574
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0069 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0182 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0069 0.0069
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0182 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Brugia malayi ecdysone receptor 0.0006 0.0044 0.0037
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0581 0.272
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0581 0.0574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0182 0.0175
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0466 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0259 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0182 0.0175
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0044 0.0037
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0349 0.0343
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0182 0.0175
Brugia malayi nuclear receptor NHR-88 0.0006 0.0044 0.0037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.1153 0.1147
Plasmodium vivax RNA helicase-1, putative 0.0466 1 1
Brugia malayi Protein kinase domain containing protein 0.0015 0.024 0.0233
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0044 0.0037
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0248 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0581 0.0574
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0182 0.0175
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0576 0.0569
Schistosoma mansoni paired box protein pax-1-related 0.0005 0.0032 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.037 0.0363
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0025
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0059 0.0052
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0259 0.0252
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0581 0.0574
Mycobacterium leprae putative cytochrome p450 0.0031 0.0581 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0083 0.0076
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0219 0.4658 0.4655
Brugia malayi nuclear hormone receptor 0.0006 0.0044 0.0037
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0182 0.0175
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0259 0.0252
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0581 0.272
Onchocerca volvulus 0.0006 0.0044 0.0037
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.1153 0.1147
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0032 0.0025
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0059 0.0052
Entamoeba histolytica hypothetical protein 0.0036 0.0692 0.0685
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0259 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0182 0.0175
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0044 0.0037
Schistosoma mansoni polycystin 1-related 0.0021 0.037 0.0363
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0248 0.0248
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0581 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.037 0.0363
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0044 0.0037
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0182 0.0175
Echinococcus multilocularis cpg binding protein 0.0032 0.0613 0.0606
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0248 0.0248
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0581 0.0574
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0044 0.0037
Brugia malayi ecdysteroid receptor 0.0012 0.0182 0.0175
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0182 0.0175
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.012 0.0114
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0259 0.0252
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0259 0.0252
Loa Loa (eye worm) hypothetical protein 0.0021 0.037 0.0363
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0581 0.272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.037 0.0363
Brugia malayi hypothetical protein 0.0006 0.0059 0.0052
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0581 0.0574
Loa Loa (eye worm) hypothetical protein 0.0015 0.0248 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1576 0.157
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0259 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.1153 0.1147
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0581 0.272
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0581 0.272
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0032 0.0025
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.1153 0.1147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.1153 0.1147
Echinococcus multilocularis muscleblind protein 1 0.018 0.3824 0.382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0182 0.0175
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0259 0.0252
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0231 0.0224
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0581 0.0574
Echinococcus multilocularis RUN 0.0021 0.037 0.0363
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0182 0.0175
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.0006 0.0059 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Brugia malayi hypothetical protein 0.0195 0.415 0.4146
Schistosoma mansoni aryl hydrocarbon receptor 0.0058 0.1181 0.1175
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0853 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0182 0.0175
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0259 0.0252
Schistosoma mansoni cpg binding protein 0.0032 0.0613 0.0606
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1153 0.1147
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0466 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0581 0.0574
Brugia malayi paired box protein 0.0005 0.0032 0.0025
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0248 0.0241
Echinococcus granulosus geminin 0.0205 0.4348 0.4344
Leishmania major eukaryotic initiation factor 4a, putative 0.0466 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0182 0.0175
Echinococcus granulosus tar DNA binding protein 0.0076 0.1576 0.157
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0044 0.0037
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0581 0.0574
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0248 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0182 0.0175
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.118 0.1174
Schistosoma mansoni single-minded 0.0058 0.1181 0.1175
Schistosoma mansoni ap endonuclease 0.002 0.0349 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0581 0.272
Brugia malayi nuclear receptor RXR 0.0006 0.0059 0.0052
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0581 0.272
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Trypanosoma brucei protein kinase, putative 0.0057 0.1153 0.1147
Loa Loa (eye worm) cytochrome P450 0.0031 0.0581 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0248 0.0248
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0259 0.0252
Brugia malayi hypothetical protein 0.0021 0.037 0.0363
Toxoplasma gondii exonuclease III APE 0.002 0.0349 0.0343
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0032 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0182 0.0175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0182 0.0175
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.12 0.1194
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0248 0.0241
Onchocerca volvulus 0.0005 0.0032 0.0025
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0044 0.0037
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0044 0.0037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0044 0.0037
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0581 0.272
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0248 0.0241
Brugia malayi RNA binding protein 0.0076 0.1576 0.157
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0083 0.0076
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1576 0.157
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0182 0.0175
Brugia malayi tailless protein 0.0006 0.0044 0.0037
Onchocerca volvulus 0.0015 0.0248 0.0241
Loa Loa (eye worm) hypothetical protein 0.018 0.3824 0.382
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0581 0.0574
Echinococcus granulosus nuclear factor of activated T cells 5 0.0219 0.4658 0.4655
Leishmania major cytochrome p450-like protein 0.0031 0.0581 0.0574
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0581 0.0574
Loa Loa (eye worm) hypothetical protein 0.0006 0.0059 0.0052
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0006 0.0059 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.12 0.1194
Echinococcus granulosus death domain containing protein 0.0014 0.0229 0.0222
Schistosoma mansoni hypothetical protein 0.0431 0.9252 0.9251
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0229 0.0222
Trypanosoma brucei cytochrome P450, putative 0.0059 0.12 0.1194
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0248 0.0241
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0259 0.0252
Loa Loa (eye worm) pax transcription factor protein 2 0.0268 0.5729 0.5726
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0581 0.272
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0466 1 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0004 0.0007 0.0007
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0007 0.0007
Leishmania major protein kinase, putative 0.0016 0.0259 0.0252
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0349 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.1153 0.1147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0182 0.0175
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0182 0.0175
Echinococcus granulosus muscleblind protein 0.018 0.3824 0.382
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0182 0.0175
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0182 0.0175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0069 0.0069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0182 0.0175
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0581 0.272
Schistosoma mansoni lipoxygenase 0.0021 0.037 0.0363
Schistosoma mansoni coup transcription factor 0.0012 0.0182 0.0175
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0248 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0182 0.0175
Loa Loa (eye worm) DR-78 0.0006 0.0044 0.0037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0349 0.0343
Leishmania major cytochrome p450-like protein 0.0031 0.0581 0.0574
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0581 0.272
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.9252 0.9251
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Loa Loa (eye worm) CYP4Cod1 0.0059 0.12 0.1194
Schistosoma mansoni hypothetical protein 0.0036 0.0692 0.0685
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0229 0.0222
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0466 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0692 0.0685
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0349 0.0343
Loa Loa (eye worm) hypothetical protein 0.0466 1 1
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0853 0.5926
Brugia malayi steroid hormone receptor 0.0012 0.0182 0.0175
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0259 0.0252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0069 0.0069
Trichomonas vaginalis Phospholipase C precursor, putative 0.0004 0.0007 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1576 0.157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0182 0.0175
Schistosoma mansoni hypothetical protein 0.0031 0.0581 0.0574
Loa Loa (eye worm) hypothetical protein 0.0014 0.0231 0.0224
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0059 0.0052
Loa Loa (eye worm) RNA binding protein 0.0076 0.1576 0.157
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0044 0.0037
Brugia malayi nuclear receptor NHR-88 0.0012 0.0182 0.0175
Echinococcus granulosus cpg binding protein 0.0032 0.0613 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0006 0.0059 0.0052
Echinococcus multilocularis geminin 0.0205 0.4348 0.4344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0014 0.0007
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0466 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0349 0.0343
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0044 0.0037
Schistosoma mansoni nuclear receptor 0.0006 0.0044 0.0037
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0032 0.0025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0349 0.0343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0069 0.0069
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0466 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0182 0.0175
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0182 0.0175
Brugia malayi nuclear receptor RXR 0.0006 0.0044 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0581 0.0574
Leishmania major eukaryotic initiation factor 4a, putative 0.0466 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0182 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0581 0.0574
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0182 0.0175
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0044 0.0037
Echinococcus granulosus paired box protein pax 1 0.0005 0.0032 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.12 0.1194
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0044 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0182 0.0175
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0059 0.0052
Brugia malayi conserved hypotetical protein 0.0006 0.0044 0.0037
Brugia malayi hypothetical protein 0.0006 0.0059 0.0052
Onchocerca volvulus 0.0005 0.0032 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Brugia malayi Doublecortin family protein 0.0021 0.037 0.0363
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0083 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1153 0.1153
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0349 0.0343
Brugia malayi Cytochrome P450 family protein 0.0059 0.12 0.1194
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0032 0.0025
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0032 0.0025
Schistosoma mansoni hypothetical protein 0.0205 0.4348 0.4344
Schistosoma mansoni zinc finger protein 0.0006 0.0044 0.0037
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0466 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0182 0.0175
Brugia malayi Muscleblind-like protein 0.018 0.3824 0.382
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0044 0.0037
Brugia malayi nuclear hormone receptor 0.0012 0.0182 0.0175
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0581 0.272
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0004 0.0007 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1153 0.1153
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.1153 0.1147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0692 0.0685
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0581 0.0574
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0182 0.0175
Brugia malayi Death domain containing protein 0.0014 0.0229 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0182 0.0175
Schistosoma mansoni hypothetical protein 0.0205 0.4348 0.4344
Echinococcus granulosus eukaryotic initiation factor 4A 0.0466 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0349 0.0343
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0229 0.0222
Echinococcus multilocularis Ankyrin 0.0014 0.0231 0.0224
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1576 0.157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0069 0.0069
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0248 0.0248
Brugia malayi TAR-binding protein 0.0076 0.1576 0.157
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0229 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0195 0.415 0.4146
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0259 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0349 0.0343
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.037 0.0363
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0182 0.0175
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0044 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0349 0.0343
Echinococcus granulosus Ankyrin 0.0014 0.0231 0.0224
Brugia malayi MAP kinase sur-1 0.0057 0.1153 0.1147
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.1153 0.1147
Brugia malayi hypothetical protein 0.0006 0.0044 0.0037
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0025
Loa Loa (eye worm) paired box protein 0.0005 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0581 0.0574
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0229 0.0222
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.131 0.1304
Echinococcus granulosus paired box protein pax 6 0.0005 0.0032 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0182 0.0175
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0123 0.0116
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0581 0.0574
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0581 0.0574
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Onchocerca volvulus 0.0043 0.0853 0.0847
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0044 0.0037
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0466 1 1
Brugia malayi Gooseberry protein 0.0005 0.0032 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0182 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0581 0.0574
Echinococcus granulosus single minded 2 0.0043 0.0853 0.0847
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0248 0.0248
Brugia malayi Cytochrome P450 family protein 0.0113 0.2358 0.2352
Schistosoma mansoni cpg binding protein 0.0032 0.0613 0.0606
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0692 0.0685
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0466 1 1
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0248 0.0248
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0123 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.037 0.0363
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1576 0.157
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1576 0.157
Schistosoma mansoni paired box protein pax-6 0.0005 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0182 0.0175
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0229 0.0222
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0581 0.0574
Loa Loa (eye worm) hypothetical protein 0.0029 0.054 0.0533
Schistosoma mansoni ap endonuclease 0.002 0.0349 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0182 0.0175
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0466 1 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0259 0.0252
Treponema pallidum ATP-dependent RNA helicase 0.0466 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0182 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0182 0.0175
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0044 0.0037
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.1153 0.1147
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0259 0.0252
Schistosoma mansoni nuclear receptor 0.0006 0.0044 0.0037
Brugia malayi PAS domain containing protein 0.0058 0.1181 0.1175
Brugia malayi vab-3 gene. 0.0005 0.0032 0.0025
Onchocerca volvulus 0.0006 0.0044 0.0037
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.037 0.0363
Onchocerca volvulus 0.0021 0.037 0.0363
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0123 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1576 0.157
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0466 1 1
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0229 0.0222
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0007 0.0007
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0248 0.0241
Leishmania major cytochrome p450-like protein 0.0059 0.12 0.1194
Brugia malayi Uncoordinated protein 44 0.0014 0.0229 0.0222
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0044 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0182 0.0175
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0466 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0692 0.0685
Loa Loa (eye worm) hypothetical protein 0.0006 0.0059 0.0052
Loa Loa (eye worm) hypoxia-induced factor 1 0.018 0.3822 0.3818
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0581 0.0574
Trichomonas vaginalis helicase, putative 0.0007 0.0069 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0083 0.0076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0083 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.018 0.3824 0.382
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0259 0.0252
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0349 0.0343
Schistosoma mansoni hypothetical protein 0.0014 0.0229 0.0222
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0007 0.0007
Echinococcus granulosus RUN 0.0021 0.037 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0182 0.0175
Schistosoma mansoni rab6-interacting 0.0021 0.037 0.0363
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0581 0.0574
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.037 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0044 0.0037
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0581 0.272
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.1153 0.1147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0069 0.0069
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.1153 0.1147
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0466 1 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0466 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.1153 0.1147
Brugia malayi hypothetical protein 0.0021 0.037 0.0363
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0059 0.0052
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0004 0.0007 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1153 0.1153
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0044 0.0037
Brugia malayi CXXC zinc finger family protein 0.003 0.0576 0.0569
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0466 1 1
Brugia malayi Cytochrome P450 family protein 0.0059 0.12 0.1194
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0182 0.0175
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0581 0.272
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0005 0.0032 0.0025
Loa Loa (eye worm) doublecortin family protein 0.0021 0.037 0.0363
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0059 0.0052
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0259 0.0252
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0349 0.0343
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0349 0.0349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0259 0.0252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0182 0.0175
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0259 0.0252
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1162 0.1155
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0581 0.272
Leishmania major protein kinase, putative 0.0016 0.0259 0.0252
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.118 0.1174
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.12 0.1194
Schistosoma mansoni cytochrome P450 0.0031 0.0581 0.0574
Brugia malayi hypoxia-induced factor 1 0.018 0.3822 0.3818
Schistosoma mansoni paired box protein pax-6 0.0005 0.0032 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0059 0.0052
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0259 0.0252
Echinococcus multilocularis paired box protein pax 1 0.0005 0.0032 0.0025
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0005 0.0032 0.0025
Loa Loa (eye worm) vab-3 0.0005 0.0032 0.0025
Entamoeba histolytica hypothetical protein 0.0036 0.0692 0.0685
Schistosoma mansoni cpg binding protein 0.003 0.0576 0.0569
Loa Loa (eye worm) hypothetical protein 0.0012 0.0182 0.0175
Brugia malayi hypothetical protein 0.0006 0.0044 0.0037
Onchocerca volvulus 0.003 0.0576 0.0569
Echinococcus multilocularis 0.0031 0.0581 0.0574
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0259 0.0252
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0004 0.0007 0.0007
Brugia malayi Pax transcription factor protein 2 0.0268 0.5729 0.5726
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0182 0.0175
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0581 0.0574
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0182 0.0175
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0248 0.0241
Brugia malayi nuclear receptor NHR-67 0.0006 0.0044 0.0037
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0248 0.0241
Echinococcus multilocularis muscleblind protein 0.018 0.3824 0.382
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0466 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0349 0.0343
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0182 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1153 0.1153
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0025
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.037 0.0363
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0229 0.0222
Entamoeba histolytica hypothetical protein 0.0036 0.0692 0.0685
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0248 0.0248
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0259 0.0252
Schistosoma mansoni hypothetical protein 0.0021 0.037 0.0363
Onchocerca volvulus 0.0012 0.0182 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0182 0.0175
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0349 0.0343
Schistosoma mansoni paired box protein pax-6 0.0005 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.0037
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0581 0.0574
Schistosoma mansoni rab6-interacting 0.0021 0.037 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0182 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0069 0.0069
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0259 0.0252
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0581 0.272
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0581 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0069 0.0069
Echinococcus granulosus paired box protein pax 6 0.0005 0.0032 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0248 0.0248
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0259 0.0252
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0853 0.0847
Brugia malayi paired box pox-meso protein 0.0005 0.0032 0.0025
Echinococcus granulosus dnaJ subfamily B 0.0431 0.9252 0.9251
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0581 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0014 0.0229 0.0222
Brugia malayi hypothetical protein 0.0036 0.0692 0.0685
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0248 0.0248
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0349 0.0343
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.2358 0.2352
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0182 0.0175
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0025
Schistosoma mansoni lipoxygenase 0.0058 0.118 0.1174
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0581 0.0574
Onchocerca volvulus 0.0021 0.037 0.0363
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.037 0.0363
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0044 0.0037
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0581 0.0574
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0044 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1576 0.157
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0349 0.0349
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0581 0.272
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0466 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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