Detailed information for compound 1292365

Basic information

Technical information
  • TDR Targets ID: 1292365
  • Name: ChemDiv3_006858
  • MW: 398.389 | Formula: C19H14N2O6S
  • H donors: 3 H acceptors: 6 LogP: 2.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc(ccc1O)NS(=O)(=O)c1ccc2c3c1cccc3c(=O)n2C
  • InChi: 1S/C19H14N2O6S/c1-21-14-6-8-16(11-3-2-4-12(17(11)14)18(21)23)28(26,27)20-10-5-7-15(22)13(9-10)19(24)25/h2-9,20,22H,1H3,(H,24,25)
  • InChiKey: DDWCKPWDWRYYLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • BAS 09620543

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.009 0.0136
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.009 0.009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0322 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.009 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.001 0.009 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Brugia malayi MH2 domain containing protein 0.001 0.009 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0129 0.2527 0.3803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0475 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Brugia malayi CXXC zinc finger family protein 0.0035 0.0599 0.0901
Schistosoma mansoni glutaminase 0.033 0.6646 0.6646
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.009 0.0135
Onchocerca volvulus Peroxidasin homolog 0.0128 0.2515 0.9952
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0475 0.9573
Schistosoma mansoni ran 0.0021 0.0322 0.0322
Brugia malayi serpin 0.0006 0.0006 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0007 0.0023 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.009 0.0136
Schistosoma mansoni nuclear hormone receptor 0.001 0.009 0.009
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0475 0.0714
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0159 0.0159
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Loa Loa (eye worm) hypothetical protein 0.0146 0.2876 0.4327
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0061 0.0523
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0134 0.4038
Entamoeba histolytica Ran family GTPase 0.0021 0.0322 0.6783
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0061 0.0492
Schistosoma mansoni smad1 5 8 and 0.001 0.009 0.009
Echinococcus granulosus sulfhydryl oxidase 1 0.0007 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0061 0.0091
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0108 0.0108
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.1083
Echinococcus granulosus cpg binding protein 0.0037 0.0639 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.009 0.0136
Leishmania major hypothetical protein, conserved 0.0029 0.0491 0.0953
Schistosoma mansoni DNA helicase recq5 0.0012 0.0134 0.0134
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.284 0.4273
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0475 0.9573
Brugia malayi serpin 0.0006 0.0006 0.0009
Echinococcus granulosus sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Trichomonas vaginalis helicase, putative 0.0008 0.0049 0.0074
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0022 0.0337 0.0337
Echinococcus multilocularis Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Brugia malayi hypothetical protein 0.0006 0.0006 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.001 0.009 0.009
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0327 0.4433
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0061 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0475 0.0922
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0366 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0737 1
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0007 0.0023 0.0069
Onchocerca volvulus Peroxidase homolog 0.0128 0.2515 0.9952
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Echinococcus multilocularis Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Schistosoma mansoni smad1 5 8 and 0.001 0.009 0.009
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0134 0.0201
Onchocerca volvulus Bile acid receptor homolog 0.001 0.009 0.0334
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0491 0.3977
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0494 0.0494
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.009 0.0136
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0061 0.0492
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0475 0.0629
Loa Loa (eye worm) Erv1/Alr family protein 0.0007 0.0023 0.0035
Schistosoma mansoni ran 0.0021 0.0322 0.0322
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0477 0.387
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.1083
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.009 0.0334
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0475 0.0629
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0206 0.4332
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0134 0.0134
Loa Loa (eye worm) serpin protein 6 0.0006 0.0006 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.5148 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0475 0.0714
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0006 0.0006 0.0049
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0322 0.4371
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0022 0.0337 0.0337
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0475 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Schistosoma mansoni sodium-dependent amino acid transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0599 0.0901
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.009 0.009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.009 0.009
Brugia malayi Blistered cuticle protein 3 0.0128 0.2515 0.3784
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.009 0.0136
Onchocerca volvulus 0.0128 0.2515 0.9952
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0475 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.009 0.009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0475 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.284 0.4273
Brugia malayi serpin (BmSERPIN) 0.0006 0.0006 0.0009
Brugia malayi glutaminase DH11.1 0.033 0.6646 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0366 0.0711
Brugia malayi hypothetical protein 0.0019 0.0277 0.0417
Brugia malayi serpin precursor 0.0006 0.0006 0.0009
Echinococcus granulosus serine protease inhibitor 0.0006 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0129 0.2527 0.3803
Brugia malayi MH1 domain containing protein 0.001 0.009 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0327 0.0404
Onchocerca volvulus Dual oxidase homolog 0.0128 0.2515 0.9952
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0061 0.0523
Leishmania major hypothetical protein, conserved 0.0041 0.0737 0.1431
Loa Loa (eye worm) hypothetical protein 0.0029 0.0477 0.0718
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.009 0.009
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0022 0.0337 0.0506
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0494 0.0936
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0482 0.0725
Brugia malayi nuclear hormone receptor 0.001 0.009 0.0136
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0061 0.0118
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Toxoplasma gondii protease inhibitor PI1 0.0006 0.0006 0.0049
Onchocerca volvulus 0.0008 0.0061 0.0217
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0061 0.0061
Onchocerca volvulus 0.0128 0.2515 0.9952
Echinococcus granulosus sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Brugia malayi steroid hormone receptor 0.001 0.009 0.0136
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0007 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Entamoeba histolytica recQ family helicase, putative 0.0006 0.0009 0.0184
Brugia malayi serpin 0.0006 0.0006 0.0009
Schistosoma mansoni serpin 0.0006 0.0006 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.009 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0022 0.0337 0.0337
Loa Loa (eye worm) norepinephrine transporter 0.0129 0.2527 0.3803
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.0337 0.0337
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0061 0.0523
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0494 0.0658
Schistosoma mansoni hypothetical protein 0.0307 0.6175 0.6175
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.009 0.009
Brugia malayi hypothetical protein 0.0022 0.0337 0.0506
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.2728
Schistosoma mansoni cpg binding protein 0.0037 0.0639 0.0639
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.009 0.0136
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0477 0.0928
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0322 0.261
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.009 0.0136
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0061 0.0118
Schistosoma mansoni thyroid hormone receptor 0.001 0.009 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0285 0.2311
Toxoplasma gondii hypothetical protein 0.0022 0.0337 0.2728
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0134 0.1814
Echinococcus multilocularis serine protease inhibitor 0.0006 0.0006 0.0006
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0061 0.0824
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0129 0.2527 0.3803
Plasmodium falciparum amino acid transporter, putative 0.0022 0.0337 0.4569
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0006 0.0009 0.0119
Schistosoma mansoni peroxidasin 0.0128 0.2515 0.2515
Brugia malayi serpin 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0475 0.0714
Plasmodium vivax importin-beta 2, putative 0.0029 0.0477 0.6482
Onchocerca volvulus Chorion peroxidase homolog 0.0128 0.2515 0.9952
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Mycobacterium ulcerans glutaminase 0.033 0.6646 1
Echinococcus granulosus bloom syndrome protein 0.0029 0.0482 0.0482
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Onchocerca volvulus 0.0008 0.0061 0.0217
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Schistosoma mansoni serpin 0.0006 0.0006 0.0006
Loa Loa (eye worm) glutaminase 2 0.033 0.6646 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0491 0.666
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0061 0.0091
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.041 0.5566
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0491 0.0929
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.009 0.0136
Mycobacterium ulcerans hypothetical protein 0.003 0.0494 0.0658
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0118
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.2728
Echinococcus multilocularis cpg binding protein 0.0037 0.0639 0.0639
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0013 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.009 0.009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1234 1
Leishmania major hypothetical protein, conserved 0.0257 0.5148 1
Onchocerca volvulus 0.0128 0.2515 0.9952
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.009 0.009
Mycobacterium ulcerans hypothetical protein 0.003 0.0494 0.0658
Plasmodium falciparum transporter, putative 0.0022 0.0337 0.4569
Schistosoma mansoni thyroid hormone receptor 0.001 0.009 0.009
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0737 1
Schistosoma mansoni cpg binding protein 0.0035 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Schistosoma mansoni smad 0.001 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.009 0.0136
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0007 0.0023 0.0023
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0061 0.0061
Toxoplasma gondii Erv1 / Alr family protein 0.0007 0.0023 0.019
Brugia malayi serpin 0.0006 0.0006 0.0009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0061 0.1279
Schistosoma mansoni importin beta-1 0.0029 0.0477 0.0477
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0061 0.0061
Mycobacterium tuberculosis Conserved protein 0.003 0.0494 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.009 0.0136
Brugia malayi serpin 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0061 0.0091
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.009 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0061 0.0824
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Plasmodium falciparum importin beta, putative 0.0029 0.0477 0.6482
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0013 0.0284
Loa Loa (eye worm) RecQ helicase 0.0029 0.0482 0.0725
Schistosoma mansoni peroxidasin 0.0128 0.2515 0.2515
Entamoeba histolytica hypothetical protein 0.0023 0.0366 0.7712
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.009 0.009
Echinococcus granulosus serine protease inhibitor 0.0006 0.0006 0.0006
Trichomonas vaginalis ran, putative 0.0021 0.0322 0.0484
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0206 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.0475 0.0714
Echinococcus multilocularis smad 0.001 0.009 0.009
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0134 0.0134
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Echinococcus granulosus serotonin transporter 0.0129 0.2527 0.2527
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0737 0.1409
Echinococcus multilocularis snurportin 1 0.0307 0.6175 0.6175
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.009 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Brugia malayi serpin (BmSERPIN) 0.0006 0.0006 0.0009
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Schistosoma mansoni Smad4 0.001 0.009 0.009
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0061 0.0523
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.009 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.009 0.009
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0482 0.0725
Echinococcus multilocularis serotonin transporter 0.0129 0.2527 0.2527
Trichomonas vaginalis glutaminase, putative 0.033 0.6646 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0108 0.0108
Echinococcus granulosus Smad4 0.001 0.009 0.009
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0737 0.1409
Mycobacterium ulcerans hypothetical protein 0.0029 0.0475 0.0629
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0061 0.0492
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.009 0.009
Loa Loa (eye worm) glutaminase 0.033 0.6646 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0061 0.0118
Echinococcus multilocularis sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0322 0.0601
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0065 0.0065
Brugia malayi Augmenter of liver regeneration 0.0041 0.0737 0.1108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.009 0.0334
Echinococcus granulosus FTZ F1 alpha 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0491 0.0738
Brugia malayi quiescin Q6 0.0007 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0134 0.0201
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0482 0.0725
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0327 0.4433
Plasmodium vivax amine transporter, putative 0.0022 0.0337 0.4569
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0737 0.5971
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0366 0.0687
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0206 0.04
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.009 0.009
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0022 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0061 0.0091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.009 0.009
Loa Loa (eye worm) solute carrier family 6 member 4 0.0129 0.2527 0.3803
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.2728
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 0.0484
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0475 0.0714
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0494 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.009 0.0135
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Brugia malayi BmSERPIN, truncated 0.0006 0.0006 0.0009
Entamoeba histolytica serine protease inhibitor, putative 0.0006 0.0006 0.0127
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0475 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0357 0.0357
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0366 0.0551
Brugia malayi Peroxidasin 0.0128 0.2515 0.3784
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.6175 0.9291
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0065 0.0065
Onchocerca volvulus 0.0035 0.0599 0.235
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0105 0.0159
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0491 0.666
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0482 0.0482
Brugia malayi MH2 domain containing protein 0.0144 0.284 0.4273
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0061 0.0523
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Brugia malayi RNA, U transporter 1 0.0082 0.1563 0.2352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.009 0.0136
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0737 0.1431
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0494 0.0658
Onchocerca volvulus Peroxidasin homolog 0.0128 0.2515 0.9952
Echinococcus granulosus plasminogen activator inhibitor 2 0.0006 0.0006 0.0006
Brugia malayi nuclear receptor NHR-88 0.001 0.009 0.0136
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0491 0.0953
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.009 0.009
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0022 0.0337 0.0337
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.009 0.009
Brugia malayi Smad1 0.001 0.009 0.0135
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0366 0.0551
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Onchocerca volvulus 0.001 0.009 0.0334
Loa Loa (eye worm) serotonin transporter b 0.0129 0.2527 0.3803
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.009 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0475 0.0922
Schistosoma mansoni smad1 5 8 and 0.001 0.009 0.009
Brugia malayi Importin beta-1 subunit 0.0029 0.0477 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.009 0.0136
Loa Loa (eye worm) Smad1 0.001 0.009 0.0135
Schistosoma mansoni cpg binding protein 0.0037 0.0639 0.0639
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0327 0.6334
Leishmania major GTP-binding protein, putative 0.0021 0.0322 0.0626
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0007 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi hypothetical protein 0.0128 0.2515 0.3784
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.009 0.009
Echinococcus granulosus Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0013 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0475 0.0714
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0023 0.0318
Echinococcus granulosus importin subunit beta 1 0.0029 0.0477 0.0477
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0491 0.666
Onchocerca volvulus 0.0129 0.2527 1
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0737 0.5971
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0134 0.0134
Schistosoma mansoni sodium/chloride dependent transporter 0.0129 0.2527 0.2527
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.009 0.009
Brugia malayi ecdysteroid receptor 0.001 0.009 0.0136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0475 0.0629
Loa Loa (eye worm) animal heme peroxidase 0.0128 0.2515 0.3784
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0475 0.0629
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0108 0.0163
Schistosoma mansoni coup transcription factor 0.001 0.009 0.009
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0129 0.2527 0.2527
Toxoplasma gondii hypothetical protein 0.0022 0.0337 0.2728
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0061 0.0092
Treponema pallidum sodium- and chloride- dependent transporter 0.0129 0.2527 1
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.009 0.009
Echinococcus granulosus peroxidasin 0.0128 0.2515 0.2515
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0092
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) steroid hormone receptor 0.001 0.009 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0475 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.009 0.009
Onchocerca volvulus 0.0029 0.0475 0.1859
Onchocerca volvulus Peroxidase homolog 0.0128 0.2515 0.9952
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 0.0484
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Onchocerca volvulus 0.0022 0.0337 0.1311
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0494 0.096
Echinococcus multilocularis sodium and chloride dependent glycine 0.0022 0.0337 0.0337
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Loa Loa (eye worm) hypothetical protein 0.0008 0.0061 0.0091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.009 0.009
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0477 0.0477
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.0337 0.0337
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.5148 1
Loa Loa (eye worm) quiescin Q6 0.0007 0.0023 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.009 0.0136
Brugia malayi MH1 domain containing protein 0.001 0.009 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.009 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0049 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0491 0.0929
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0065 0.0065
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.0201
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0013 0.0109
Brugia malayi MH2 domain containing protein 0.001 0.009 0.0135
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.029 0.3935
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.009 0.009
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0007 0.0023 0.0019
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0061 0.0523
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi hypothetical protein 0.0029 0.0491 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0049 0.0074
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0737 0.1108
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0737 0.1409
Onchocerca volvulus 0.0008 0.0061 0.0217
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0477 0.0928
Onchocerca volvulus 0.0008 0.0061 0.0217
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0737 0.0737
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0061 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.009 0.0136
Echinococcus multilocularis sulfhydryl oxidase 1 0.0007 0.0023 0.0023
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0494 0.0494
Loa Loa (eye worm) oxidoreductase 0.0008 0.0061 0.0091
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0061 0.0091
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0322 0.4371
Brugia malayi BmSERPIN 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Echinococcus granulosus serine protease inhibitor 0.0006 0.0006 0.0006
Echinococcus granulosus snurportin 1 0.0307 0.6175 0.6175
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0061 0.0092
Brugia malayi hypothetical protein 0.0006 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.2515 0.3784
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0322 0.0322
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0134 0.0201
Loa Loa (eye worm) hypothetical protein 0.0129 0.2527 0.3803
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Onchocerca volvulus 0.0022 0.0337 0.1311
Echinococcus multilocularis Smad4 0.001 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.009 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0337 0.4569
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0065 0.0065
Echinococcus multilocularis peroxidasin 0.0128 0.2515 0.2515
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0065 0.0065
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0494 0.0936
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0136
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.0337 0.0337
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0322 0.0322
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0061 0.0523
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0303 0.5811
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.0337 0.0506
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1395 0.1395
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.009 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0475 0.0629
Loa Loa (eye worm) serpin 0.0006 0.0006 0.0009
Loa Loa (eye worm) blistered cuticle protein 3 0.0128 0.2515 0.3784
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0506
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0494 0.0744
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0475 0.0629
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0159 0.0159
Echinococcus granulosus smad 0.001 0.009 0.009
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0061 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0006 0.0013 0.002
Schistosoma mansoni DNA helicase recq1 0.0012 0.0134 0.0134
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0322 0.0626
Echinococcus granulosus Estrogen regulated protein EP45 0.0006 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.5148 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0737 0.0737
Brugia malayi Serpin protein 6 0.0006 0.0006 0.0009
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0206 0.04
Schistosoma mansoni serine protease inhibitors serpins 0.0006 0.0006 0.0006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0007 0.0023 0.0318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0049 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0475 0.0629
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.009 0.009
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0206 0.0374
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0009
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0022 0.0337 0.0337
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0022 0.0337 0.0337
Brugia malayi Erv1 / Alr family protein 0.0007 0.0023 0.0035
Brugia malayi Animal haem peroxidase family protein 0.0128 0.2515 0.3784
Echinococcus multilocularis serine protease inhibitor 0.0006 0.0006 0.0006
Onchocerca volvulus 0.0022 0.0337 0.1311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0327 0.0491
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0007 0.0023 0.0069

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS): Hit Confirmation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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