Detailed information for compound 1309158

Basic information

Technical information
  • TDR Targets ID: 1309158
  • Name: 2-(3,5-dimethylpiperidin-1-yl)-7-(4-methylphe nyl)-7,8-dihydro-6H-quinazolin-5-one
  • MW: 349.469 | Formula: C22H27N3O
  • H donors: 0 H acceptors: 3 LogP: 4.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)CN(C1)c1ncc2c(n1)CC(CC2=O)c1ccc(cc1)C
  • InChi: 1S/C22H27N3O/c1-14-4-6-17(7-5-14)18-9-20-19(21(26)10-18)11-23-22(24-20)25-12-15(2)8-16(3)13-25/h4-7,11,15-16,18H,8-10,12-13H2,1-3H3
  • InChiKey: MFQYKKPLFPHEMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,5-dimethyl-1-piperidyl)-7-(4-methylphenyl)-7,8-dihydro-6H-quinazolin-5-one
  • 2-(3,5-dimethyl-1-piperidinyl)-7-(4-methylphenyl)-7,8-dihydro-6H-quinazolin-5-one
  • MLS000040741
  • STK211313
  • SMR000044209

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.104 0.6458 1
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0105 0.0579 0.0892
Onchocerca volvulus 0.0022 0.0061 0.0086
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0049 0.0189
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0215 0.0328
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus neuropeptide receptor 0.0022 0.0061 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0062 0.026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.2866 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0381 0.0378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Leishmania major diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Trichomonas vaginalis porcupine, putative 0.0021 0.0049 0.0244
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Echinococcus granulosus hypothetical protein 0.0022 0.0061 0.009
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0123 0.0691 0.1066
Brugia malayi hypothetical protein 0.0131 0.0743 0.1141
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0381 0.1252
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0071 0.0369 0.055
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0061 0.0058
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0061 0.0085
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0071 0.0067
Brugia malayi hypothetical protein 0.0071 0.0369 0.0562
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0061 0.009
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0062 0.0339
Echinococcus granulosus orexin receptor type 2 0.0022 0.0061 0.009
Onchocerca volvulus 0.0073 0.0381 0.2417
Echinococcus granulosus somatostatin receptor 0.0022 0.0061 0.009
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0027 0.0092 0.0132
Echinococcus multilocularis musashi 0.0028 0.0093 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Brugia malayi follicle stimulating hormone receptor 0.03 0.1808 0.2792
Loa Loa (eye worm) hypothetical protein 0.0105 0.0579 0.0896
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0222
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0069 0.044
Echinococcus granulosus neuropeptide receptor A26 0.0578 0.3555 0.5502
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0107
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0098 0.0147
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0185 0.0182
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0381 0.265
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0061 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0336 0.0498
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0105 0.0579 0.0576
Mycobacterium ulcerans beta-lactamase 0.0073 0.0381 0.3864
Schistosoma mansoni zinc finger protein 0.0021 0.0049 0.0054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0031 0.0027
Echinococcus granulosus geminin 0.0167 0.0971 0.1499
Brugia malayi GNT-I family protein 0.0105 0.0579 0.0887
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0139
Leishmania major methionyl-tRNA synthetase, putative 0.0058 0.0283 0.1459
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0062 0.0339
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0381 0.265
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0215 0.0311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0292 0.2894
Echinococcus granulosus intermediate filament protein 0.0028 0.0093 0.0139
Loa Loa (eye worm) beta-lactamase 0.0073 0.0381 0.059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0292 0.1508
Schistosoma mansoni opsin-like receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0105 0.0578 0.0895
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0017 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0041 0.0179 0.0278
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0061 0.0072
Brugia malayi Bromodomain containing protein 0.0076 0.0396 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Treponema pallidum leucyl-tRNA synthetase 0.0022 0.0059 0.6987
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0027 0.0092 0.0419
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0049 0.0244
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0381 0.265
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0383 0.2666
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0027 0.0092 0.0309
Echinococcus granulosus dnaJ subfamily B 0.0437 0.2667 0.4128
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0049 0.0076
Brugia malayi Serotonin receptor 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0052 0.0245 0.038
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Brugia malayi CHD4 protein 0.0016 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0048 0.0074
Brugia malayi Dopamine receptor 0.0022 0.0061 0.0085
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0381 0.1252
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0152
Brugia malayi Pre-SET motif family protein 0.003 0.0109 0.0159
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0061 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1691 0.2602
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Schistosoma mansoni sterol O-acyltransferase 1 0.0021 0.0049 0.0054
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0061 0.0058
Brugia malayi hypothetical protein 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0062 0.0092
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0837 0.4461
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0019
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0045
Schistosoma mansoni adenoreceptor 0.0022 0.0061 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1691 0.1688
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0179 0.0949
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0381 0.1252
Schistosoma mansoni ap endonuclease 0.0023 0.0062 0.0074
Toxoplasma gondii hypothetical protein 0.005 0.0232 0.3072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0549 0.0829
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0061 0.0095
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0021 0.0049 0.0072
Echinococcus multilocularis protein dispatched 1 0.0048 0.0223 0.022
Mycobacterium ulcerans hypothetical protein 0.0073 0.0381 0.3864
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0058 0.0283 0.1943
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0061 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.104 0.6458 0.6457
Echinococcus granulosus GPCR family 2 0.0048 0.0224 0.0343
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0061 0.0072
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.4157 0.6428
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0381 0.1252
Leishmania major hypothetical protein, conserved 0.0021 0.0049 0.0189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0018 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0071 0.0104
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0381 0.0585
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.0656
Onchocerca volvulus Huntingtin homolog 0.0131 0.0743 0.5055
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.0049 0.0046
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0061 0.0058
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0049 0.0189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi Pax transcription factor protein 2 0.0239 0.1421 0.2192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1691 0.2615
Loa Loa (eye worm) hypothetical protein 0.007 0.0358 0.0555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.0049 0.0054
Schistosoma mansoni chromobox protein 0.0074 0.0383 0.0572
Onchocerca volvulus 0.0031 0.0113 0.0461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1857 1
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0123 0.0691 0.107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0078 0.0412 0.0637
Echinococcus multilocularis lamin 0.0028 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0131 0.0743 0.115
Leishmania major leucyl-tRNA synthetase, putative 0.0022 0.0059 0.0238
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0069 0.0154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0062 0.0475
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0061 0.0072
Echinococcus multilocularis lysosomal protective protein 0.0027 0.0092 0.0089
Brugia malayi neuropeptide F receptor 0.0022 0.0061 0.0085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0061 0.009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0069 0.0398
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Mycobacterium ulcerans hypothetical protein 0.0024 0.0069 0.044
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Brugia malayi methionyl-tRNA synthetase 0.0058 0.0283 0.0429
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0109 0.0106
Echinococcus granulosus serotonin receptor 0.0022 0.0061 0.009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0224 0.0343
Echinococcus granulosus g protein coupled receptor 0.0022 0.0061 0.009
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0061 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0039 0.017
Brugia malayi Melatonin receptor type 1A 0.0022 0.0061 0.0085
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0061 0.009
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.0049 0.0046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0061 0.009
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0097
Echinococcus multilocularis sterol O acyltransferase 1 0.0021 0.0049 0.0046
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0018 0.0028
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0069 0.044
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0049 0.0054
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0062 0.026
Brugia malayi CXXC zinc finger family protein 0.0031 0.0113 0.0164
Echinococcus multilocularis cpg binding protein 0.0034 0.0135 0.0132
Schistosoma mansoni ap endonuclease 0.0023 0.0062 0.0074
Brugia malayi ORL1-like opioid receptor 0.0022 0.0061 0.0085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.009
Onchocerca volvulus 0.0022 0.0061 0.0086
Onchocerca volvulus 0.0022 0.0061 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0167 0.0971 0.1484
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.0325
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.1691 0.2618
Echinococcus granulosus chromobox protein 1 0.0074 0.0383 0.0589
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0539 0.0835
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0381 0.265
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0061 0.009
Onchocerca volvulus 0.0022 0.0061 0.0086
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0123 0.0691 1
Chlamydia trachomatis leucine--tRNA ligase 0.0022 0.0059 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0062 0.026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0062 0.026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0061 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0061 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.104 0.6458 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0062 0.0132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0883 0.1358
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0188
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0049 0.0072
Echinococcus multilocularis lamin dm0 0.0028 0.0093 0.009
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0215 0.0212
Schistosoma mansoni hypothetical protein 0.0437 0.2667 0.4117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0107
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0301 0.0298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0224 0.0221
Loa Loa (eye worm) hhat protein 0.0021 0.0049 0.0076
Brugia malayi GnHR receptor homolog 0.0022 0.0061 0.0085
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0061 0.0086
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0021 0.0049 0.0046
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.2667 0.2665
Echinococcus granulosus neuropeptide receptor 0.0022 0.0061 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.094 0.3221
Echinococcus multilocularis tumor protein p63 0.0338 0.2045 0.2043
Echinococcus multilocularis chromobox protein 1 0.0074 0.0383 0.038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.004 0.0172 0.0267
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.0049 0.0072
Brugia malayi Dopamine receptor protein 2 0.0022 0.0061 0.0085
Schistosoma mansoni lamin 0.0028 0.0093 0.0121
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0027 0.0092 0.0419
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0062 0.0475
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.044
Brugia malayi beta-lactamase family protein 0.0073 0.0381 0.058
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0061 0.0072
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0301 0.0461
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0061 0.009
Echinococcus multilocularis chromobox protein 1 0.0074 0.0383 0.038
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0024 0.0069 0.0142
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0192 0.0963
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Trichomonas vaginalis transmembrane protein nessy, putative 0.0021 0.0049 0.0244
Loa Loa (eye worm) hypothetical protein 0.0049 0.0231 0.0357
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0185 0.0264
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0123 0.0691 0.0688
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Schistosoma mansoni intermediate filament proteins 0.0028 0.0093 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Schistosoma mansoni hypothetical protein 0.0167 0.0971 0.1484
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Echinococcus granulosus g protein coupled receptor 0.0022 0.0061 0.009
Schistosoma mansoni hypothetical protein 0.0105 0.0578 0.0874
Loa Loa (eye worm) hypothetical protein 0.0105 0.0579 0.0896
Echinococcus granulosus tumor protein p63 0.0338 0.2045 0.3164
Echinococcus granulosus neuropeptide s receptor 0.0578 0.3555 0.5502
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0539 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Plasmodium falciparum methionine--tRNA ligase, putative 0.0022 0.0059 0.0415
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0025 0.0075 0.0072
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0062 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0381 0.059
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1393 1
Echinococcus granulosus chromobox protein 1 0.0074 0.0383 0.0589
Plasmodium vivax SET domain protein, putative 0.003 0.0109 0.1181
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0061 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0292 0.2894
Schistosoma mansoni lamin 0.0028 0.0093 0.0121
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0199 0.1331
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1215 0.1881
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0231 0.0336
Echinococcus granulosus sterol O acyltransferase 1 0.0021 0.0049 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Toxoplasma gondii ABC1 family protein 0.0073 0.0381 0.5317
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0061 0.0072
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0061 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0069 0.0154
Loa Loa (eye worm) hypothetical protein 0.0153 0.0883 0.1367
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0061 0.0095
Echinococcus multilocularis zinc finger protein 0.0021 0.0052 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0292 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.104 0.6458 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0025 0.0017
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0224 0.0221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0062 0.0371
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0381 0.1252
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0062 0.0176
Loa Loa (eye worm) follicle stimulating hormone receptor 0.03 0.1808 0.2799
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0061 0.0095
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Echinococcus multilocularis protein patched 0.0042 0.0185 0.0182
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0383 0.0593
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0191
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0058 0.0283 0.1459
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0061 0.0058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0192 0.0963
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0051
Echinococcus granulosus cpg binding protein 0.0034 0.0135 0.0205
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0224 0.0338
Schistosoma mansoni opsin-like receptor 0.0022 0.0061 0.0072
Leishmania major hypothetical protein, conserved 0.0073 0.0381 0.1988
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0022 0.0059 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0027 0.0092 0.0419
Brugia malayi protein ZK524.3 0.0022 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1691 0.2602
Schistosoma mansoni zinc finger protein 0.0021 0.0052 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0244
Echinococcus multilocularis GPCR, family 2 0.0048 0.0224 0.0221
Echinococcus granulosus microtubule associated protein 2 0.0674 0.4157 0.6435
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0307 0.4197
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0061 0.0072
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0069 0.044
Brugia malayi Bromodomain containing protein 0.0038 0.0157 0.0234
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0381 0.0568
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Echinococcus granulosus fmrfamide receptor 0.0022 0.0061 0.009
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0074 0.0691
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0058 0.0283 0.0909
Leishmania major diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Brugia malayi Hhat protein 0.0021 0.0049 0.0066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1691 0.2602
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0061 0.009
Echinococcus granulosus lamin 0.0028 0.0093 0.0139
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0192 0.0963
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0252 0.1287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi hypothetical protein 0.0025 0.0074 0.0105
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Chlamydia trachomatis methionine--tRNA ligase 0.0022 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0049 0.0072
Brugia malayi Dopamine receptor protein 1 0.0022 0.0061 0.0085
Loa Loa (eye worm) hhat protein 0.0021 0.0049 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0294
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Brugia malayi AKH receptor 0.0022 0.0061 0.0085
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1691 0.1688
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0049 0.0189
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0369 0.0567
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0638
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis esterase, putative 0.0073 0.0381 0.265
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0061 0.0072
Brugia malayi methionyl-tRNA synthetase 0.0022 0.0059 0.0081
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0025 0.0075 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Onchocerca volvulus 0.0022 0.0061 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0381 0.0568
Toxoplasma gondii hypothetical protein 0.0021 0.0049 0.0312
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0058 0.0283 0.2795
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0078 0.0412 0.0616
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0381 0.058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0224 0.0338
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0234 0.1393 0.9799
Mycobacterium leprae Probable lipase LipE 0.0073 0.0381 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0837 0.4461
Onchocerca volvulus 0.0239 0.1421 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0143 0.0216
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.0058
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0018 0.0015
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0061 0.009
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0049 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Schistosoma mansoni hypothetical protein 0.0021 0.0049 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0837 0.4461
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0027 0.0092 0.012
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0061 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0185 0.0287
Loa Loa (eye worm) hypothetical protein 0.0044 0.0195 0.0302
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0144
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0093 0.0144
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0093 0.0144
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0105 0.0579 0.0875
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0091
Brugia malayi G-protein coupled receptor 0.0022 0.0061 0.0085
Onchocerca volvulus 0.0022 0.0061 0.0086
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0049 0.0046
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0093 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0061 0.009
Toxoplasma gondii exonuclease III APE 0.0023 0.0062 0.0511
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0061 0.0058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0061 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Echinococcus granulosus sex peptide receptor 0.0022 0.0061 0.009
Onchocerca volvulus 0.0022 0.0061 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0185 0.1232
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0061 0.0058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0292 0.0289
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.0656
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0058 0.0283 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni patched 1 0.0042 0.0185 0.0265
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Brugia malayi RE15519p 0.0022 0.0061 0.0085
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0061 0.0058
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0185 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0578 0.0886
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.0049 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0061 0.0072
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0073 0.0381 0.2417
Brugia malayi diacylglycerol acyltransferase 0.0123 0.0691 0.1061
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0061 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0023
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0017 0.0029 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.1691 0.2611
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0143 0.0139
Toxoplasma gondii hypothetical protein 0.0042 0.0181 0.2305
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.0049 0.0054
Onchocerca volvulus 0.0022 0.0061 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0061 0.0058
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0805 0.0802
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0036 0.0145 0.0224
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0381 0.1252
Mycobacterium tuberculosis Conserved protein 0.0073 0.0381 0.1252
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Mycobacterium ulcerans hypothetical protein 0.0162 0.094 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0061 0.0058
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0381 0.1988
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Brugia malayi chromobox protein homolog 3 0.0041 0.0179 0.0268
Brugia malayi Glycosylation related protein 12, isoform 0.0036 0.0143 0.0212
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0061 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0294
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0123 0.0691 1
Schistosoma mansoni biogenic amine receptor 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Echinococcus granulosus allatostatin A receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0097
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0062 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0224 0.0347
Brugia malayi intermediate filament protein 0.0028 0.0093 0.0134
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0061 0.009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0071 0.0087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0381 0.1252
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.0325
Trypanosoma cruzi GUP1, putative 0.0021 0.0049 0.0189
Echinococcus multilocularis neuropeptide receptor A26 0.0578 0.3555 0.3553
Schistosoma mansoni biogenic amine receptor 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0022 0.0061 0.0086
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Onchocerca volvulus 0.0022 0.0061 0.0086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0039 0.017
Brugia malayi G protein-coupled receptor 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Onchocerca volvulus 0.0032 0.0123 0.0539
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0061 0.0058
Schistosoma mansoni histamine h1 receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0061 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0381 0.1988
Plasmodium vivax methionine--tRNA ligase, putative 0.0058 0.0283 0.3823
Echinococcus multilocularis serotonin receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0058 0.0283 0.0439
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni chromobox protein 0.0074 0.0383 0.0572
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0061 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Echinococcus granulosus g protein coupled receptor 0.0022 0.0061 0.009
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.1857 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0049 0.0046
Onchocerca volvulus 0.0042 0.0185 0.0989
Toxoplasma gondii tRNA ligases class I (M) protein 0.0022 0.0059 0.0451
Onchocerca volvulus 0.0028 0.0093 0.0316
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0049 0.0244
Brugia malayi Pre-SET motif family protein 0.0206 0.1215 0.1873
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0107
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0027 0.0092 0.0419
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0061 0.0085
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0069 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0179 0.1188
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0292 0.0448
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0381 0.265
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.044
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0539 0.0825
Brugia malayi larval opioid receptor 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Treponema pallidum methionyl-tRNA synthetase 0.0022 0.0059 0.6987
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus multilocularis expressed conserved protein 0.0093 0.0501 0.0498
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0061 0.0072
Echinococcus multilocularis serotonin receptor 0.0022 0.0061 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis sex peptide receptor 0.0022 0.0061 0.0058
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0058 0.0283 0.1459
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.104 0.6458 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1691 0.2615
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0188
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0025 0.0017
Onchocerca volvulus Huntingtin homolog 0.0131 0.0743 0.5055
Loa Loa (eye worm) pax transcription factor protein 2 0.0239 0.1421 0.22
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0113 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0883 0.1358
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0036 0.0143 0.1729
Echinococcus granulosus lamin dm0 0.0028 0.0093 0.0139
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0224 0.0343
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0123 0.0691 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0074 0.0656
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0061 0.0085
Echinococcus multilocularis neuropeptide s receptor 0.0578 0.3555 0.3553
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0031 0.0021
Brugia malayi beta-lactamase family protein 0.0073 0.0381 0.058
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0061 0.0058
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0025 0.0035
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0061 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis somatostatin receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0061 0.0058
Leishmania major hypothetical protein, conserved 0.0025 0.0074 0.0325
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0062 0.0097
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0061 0.0058
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Brugia malayi diacylglycerol acyltransferase family protein 0.0078 0.0412 0.0628
Giardia lamblia Methionyl-tRNA synthetase 0.0058 0.0283 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0292 0.3982
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0058 0.0283 0.6877
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.0049 0.0072
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0049 0.0189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0638
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Brugia malayi sulfakinin receptor protein 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.0049 0.0072
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0369 0.055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0109 0.0147
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0061 0.009
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0049 0.0189
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.044
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.4157 0.4155
Onchocerca volvulus 0.0022 0.0061 0.0086
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0539 0.083
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0215 0.0311
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0022 0.0059 0.0188
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi beta-lactamase 0.0073 0.0381 0.058
Echinococcus granulosus lysosomal protective protein 0.0027 0.0092 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Leishmania major diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0049 0.0054
Brugia malayi Heterochromatin protein 1 0.0074 0.0383 0.0584
Echinococcus granulosus zinc finger protein 0.0021 0.0052 0.0076
Loa Loa (eye worm) hypothetical protein 0.0131 0.0743 0.115
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0805 0.1242
Echinococcus multilocularis methionine tRNA synthetase 0.0058 0.0283 0.028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0019 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0062 0.0087
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0123 0.0691 0.105
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0022 0.0061 0.0086
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0049 0.0054
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.0049 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0049 0.0244
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0381 0.3864
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0061 0.009
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus multilocularis leucyl tRNA synthetase 0.0022 0.0059 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0022 0.0061 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0199 0.1331
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0061 0.009
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0025 0.0022
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0018 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0329 0.227
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0061 0.009
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0022 0.0059 0.0086
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0292 0.0941
Brugia malayi putative neuropeptide receptor 0.0022 0.0061 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1857 1
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0061 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0294
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0369 0.0366
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0022
Echinococcus granulosus expressed conserved protein 0.0093 0.0501 0.0772
Brugia malayi CHE-14 protein 0.0042 0.0185 0.0277
Brugia malayi neuropeptide F receptor 0.0022 0.0061 0.0085
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0199 0.1092
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0074 0.0325
Onchocerca volvulus 0.0049 0.0231 0.1323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0287
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0123 0.0691 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0381 0.1988
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0061 0.0058
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0061 0.0085
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0061 0.0095
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni biogenic amine receptor 0.0022 0.0061 0.0072
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0061 0.009
Schistosoma mansoni bromodomain containing protein 0.0064 0.0323 0.0479
Toxoplasma gondii dgat2l1-prov protein 0.0078 0.0412 0.5782
Echinococcus granulosus methionine tRNA synthetase 0.0058 0.0283 0.0434
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0059 0.0415
Brugia malayi G-protein coupled receptor 0.0022 0.0061 0.0085
Onchocerca volvulus 0.0022 0.0061 0.0086
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0062 0.0269
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0062 0.0059
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0022 0.0061 0.0086
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.1857 1
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Brugia malayi PHD-finger family protein 0.0026 0.0085 0.0122
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0061 0.009
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0292 0.0431
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0292 0.2894
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Schistosoma mansoni opsin-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Mycobacterium ulcerans lipase LipD 0.0073 0.0381 0.3864
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0061 0.0085
Plasmodium falciparum methionine--tRNA ligase 0.0058 0.0283 0.3823
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0061 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0381 0.5299
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.009
Onchocerca volvulus 0.0073 0.0381 0.2417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0224 0.0347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0883 0.1367
Toxoplasma gondii methionyl-tRNA synthetase 0.0058 0.0283 0.3846
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0061 0.0085
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0185 0.0282
Onchocerca volvulus 0.0022 0.0061 0.0086
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Trypanosoma cruzi GUP1, putative 0.0021 0.0049 0.0189
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0381 0.3864
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0192 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0179 0.1188
Mycobacterium tuberculosis Conserved protein 0.0073 0.0381 0.1252
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0061 0.009
Onchocerca volvulus 0.0078 0.0412 0.2642
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0017 0.0029 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0109 0.1214
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0383 0.2666
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0061 0.0085
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0027 0.0092 0.012
Schistosoma mansoni methionine-tRNA synthetase 0.0058 0.0283 0.0417
Schistosoma mansoni myosin xvIII 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0022 0.0061 0.0086
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0069 0.0398
Plasmodium vivax methionine--tRNA ligase, putative 0.0022 0.0059 0.0415
Schistosoma mansoni methionine-tRNA synthetase 0.0022 0.0059 0.0068
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0022 0.0059 0.0328
Onchocerca volvulus 0.0028 0.0093 0.0316
Mycobacterium tuberculosis Conserved protein 0.0073 0.0381 0.1252
Onchocerca volvulus 0.0036 0.0145 0.0694
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0102 0.0561 0.0869
Schistosoma mansoni leucyl-tRNA synthetase 0.0022 0.0059 0.0068
Brugia malayi Serotonin receptor 0.0022 0.0061 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0069 0.044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Echinococcus multilocularis geminin 0.0167 0.0971 0.0968

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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