Detailed information for compound 1318651

Basic information

Technical information
  • TDR Targets ID: 1318651
  • Name: 8-[(3-methoxyphenyl)methyl]-2-piperazin-1-yl- 6-thiophen-2-ylpteridin-7-one
  • MW: 434.514 | Formula: C22H22N6O2S
  • H donors: 1 H acceptors: 3 LogP: 2.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)Cn1c2nc(ncc2nc(c1=O)c1cccs1)N1CCNCC1
  • InChi: 1S/C22H22N6O2S/c1-30-16-5-2-4-15(12-16)14-28-20-17(25-19(21(28)29)18-6-3-11-31-18)13-24-22(26-20)27-9-7-23-8-10-27/h2-6,11-13,23H,7-10,14H2,1H3
  • InChiKey: VORMSOCEUSVILQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 8-[(3-methoxyphenyl)methyl]-2-piperazin-1-yl-6-(2-thienyl)pteridin-7-one
  • 8-[(3-methoxyphenyl)methyl]-2-(1-piperazinyl)-6-(2-thienyl)-7-pteridinone
  • 8-(3-methoxybenzyl)-2-piperazin-1-yl-6-(2-thienyl)pteridin-7-one
  • 8-[(3-methoxyphenyl)methyl]-2-piperazin-1-yl-6-thiophen-2-yl-pteridin-7-one
  • NCGC00011984
  • PCOP-677892

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus snurportin 1 0.0298 0.2884 0.2884
Leishmania major cathepsin L-like protease 0.002 0.0061 0.0281
Loa Loa (eye worm) hypothetical protein 0.0174 0.162 0.5617
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0104 0.0413
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0398 0.2075
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.2281 0.791
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0062 0.0481 0.2542
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0037 0.0231 0.137
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.07 0.07
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.003 0.003
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0366 0.3573 1
Echinococcus multilocularis cysteine protease 0.002 0.0061 0.0061
Echinococcus multilocularis jun protein 0.0083 0.07 0.07
Schistosoma mansoni polycystin 1-related 0.0024 0.0097 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0052 0.0229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.017 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.021 0.021
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0186 0.0646
Loa Loa (eye worm) fibroinase 0.002 0.0061 0.0211
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0105 0.0589
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0174 0.162 0.8976
Loa Loa (eye worm) hypothetical protein 0.0033 0.0186 0.0646
Echinococcus granulosus jun protein 0.0083 0.07 0.07
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0062 0.0481 0.2923
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.057 0.3121
Loa Loa (eye worm) hypothetical protein 0.01 0.0876 0.3036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Trypanosoma cruzi metacaspase, putative 0.0053 0.0398 0.2162
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0025 0.0105 0.0589
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.003 0.0165 0.0165
Echinococcus multilocularis caspase 0.0141 0.129 0.129
Mycobacterium ulcerans valyl-tRNA synthetase 0.0062 0.0481 0.1219
Brugia malayi isocitrate dehydrogenase 0.0031 0.017 0.0703
Plasmodium falciparum metacaspase 1 0.0053 0.0398 0.0815
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0228 0.079
Schistosoma mansoni rab6-interacting 0.0024 0.0097 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0061 0.0061
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Entamoeba histolytica protein kinase, putative 0.0017 0.003 0.005
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0165 0.0165
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0165 0.0165
Echinococcus multilocularis lamin dm0 0.0033 0.0186 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1118 0.1118
Schistosoma mansoni lipoxygenase 0.0142 0.1302 0.1302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Brugia malayi beta-NAC-like protein 0.0035 0.0208 0.087
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0062 0.0481 0.2624
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.003 0.003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0341 0.184
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Onchocerca volvulus 0.005 0.0361 0.2689
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0662 0.0662
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0139 0.0658
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0061 0.0241
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0705 0.1854
Loa Loa (eye worm) ACC-1 protein 0.003 0.0165 0.0573
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0428 0.4199 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0052 0.0052
Schistosoma mansoni microtubule-associated protein tau 0.068 0.6759 0.6759
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0097 0.0097
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0174 0.162 0.3768
Toxoplasma gondii aldehyde dehydrogenase 0.018 0.1685 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0061 0.0061
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0165 0.0165
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0097 0.0234
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0142 0.0258
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0165 0.0681
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0061 0.0061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0165 0.0681
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0165 0.0165
Echinococcus granulosus tar DNA binding protein 0.0124 0.1118 0.1118
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0064 0.0299
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0165 0.0165
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0174 0.162 0.162
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0192 0.1803 0.6253
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0341 0.0341
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0139 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Loa Loa (eye worm) hypothetical protein 0.009 0.0771 0.2672
Plasmodium vivax importin-beta 2, putative 0.0028 0.0139 0.0502
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0366 0.3573 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0484 0.0484
Loa Loa (eye worm) VRS-2 protein 0.0025 0.0105 0.0366
Brugia malayi hypothetical protein 0.0024 0.0104 0.0409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0164 0.1519 0.1519
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0104 0.0103
Brugia malayi Cathepsin L-like precursor 0.002 0.0061 0.0221
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0062 0.0481 0.1219
Echinococcus multilocularis Smad4 0.0016 0.0021 0.0021
Schistosoma mansoni lamin 0.0033 0.0186 0.0186
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0705 0.1854
Echinococcus multilocularis GPCR, family 2 0.0015 0.0011 0.0011
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0031 0.0175 0.0606
Loa Loa (eye worm) hypothetical protein 0.0053 0.0398 0.1381
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0346 0.1477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Onchocerca volvulus 0.002 0.0061 0.0454
Echinococcus multilocularis RUN 0.0024 0.0097 0.0097
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Trypanosoma cruzi metacaspase, putative 0.0053 0.0398 0.2162
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0638 0.35
Brugia malayi hypothetical protein 0.0035 0.021 0.0876
Schistosoma mansoni hypothetical protein 0.009 0.0771 0.0771
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.018 0.1685 0.1685
Schistosoma mansoni atypical protein kinase C 0.0029 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0398 0.1707
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0052 0.0052
Brugia malayi protein kinase C II. 0.0031 0.0175 0.0723
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.003 0.0105
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0061 0.0211
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0064 0.0022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0398 0.2223
Brugia malayi protein ZK524.3 0.0025 0.0105 0.0417
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0191 0.0793
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0236
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.017 0.0591
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0341 0.0341
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0147 0.135 0.135
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0341 0.184
Plasmodium falciparum valine--tRNA ligase, putative 0.0062 0.0481 0.1015
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.003 0.0165 0.0165
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0192 0.1803 0.7896
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.2281 0.791
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0484 0.0484
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0705 0.1854
Loa Loa (eye worm) hypothetical protein 0.0085 0.0723 0.2506
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0165 0.0165
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.003 0.0165 0.0165
Giardia lamblia Leucyl-tRNA synthetase 0.0025 0.0105 0.0343
Echinococcus granulosus neuropeptide receptor A26 0.0921 0.9216 0.9216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Brugia malayi Cytochrome P450 family protein 0.0036 0.022 0.0921
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.002 0.0052
Mycobacterium tuberculosis Probable reductase 0.0084 0.0705 0.1854
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0799 0.2214
Loa Loa (eye worm) Smad1 0.0016 0.0021 0.0072
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1118 0.1118
Schistosoma mansoni eyes absent homolog 0.0085 0.0723 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0052 0.0255
Brugia malayi intermediate filament protein 0.0033 0.0186 0.0774
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.124 0.124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0086 0.0466
Entamoeba histolytica cysteine protease, putative 0.002 0.0061 0.0241
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0774 0.0774
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0366 0.3573 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.003 0.0165 0.0165
Echinococcus multilocularis protein dispatched 1 0.0047 0.033 0.033
Schistosoma mansoni rab6-interacting 0.0024 0.0097 0.0097
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0165 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0021 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Onchocerca volvulus Cathepsin F homolog 0.002 0.0061 0.0454
Brugia malayi Cation transporter family protein 0.003 0.0165 0.0681
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0139 0.0614
Echinococcus granulosus microtubule associated protein 2 0.068 0.6759 0.6759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0186 0.0774
Leishmania major DNA polymerase kappa, putative 0.0019 0.0052 0.0229
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.2884 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.017 0.0337
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0081
Treponema pallidum valyl-tRNA synthetase 0.0062 0.0481 0.2292
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0086 0.0466
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0799 0.2123
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0174 0.162 0.162
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0366
Plasmodium vivax metacaspase 1, putative 0.0053 0.0398 0.2163
Brugia malayi Cathepsin L-like precursor 0.002 0.0061 0.0221
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0104 0.0103
Schistosoma mansoni neurotransmitter gated ion channel 0.0016 0.0022 0.0022
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0011 0.0037
Brugia malayi hypothetical protein 0.005 0.0361 0.1543
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0398 0.0398
Chlamydia trachomatis isoleucine--tRNA ligase 0.0174 0.162 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.017 0.0846
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1685 0.4638
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.4089 0.4089
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0165 0.0165
Echinococcus multilocularis snurportin 1 0.0298 0.2884 0.2884
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0052 0.0052
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0011 0.0011
Echinococcus multilocularis sodium channel protein 0.0147 0.135 0.135
Echinococcus multilocularis neuropeptide s receptor 0.0921 0.9216 0.9216
Echinococcus multilocularis lamin 0.0033 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0197 0.1855 0.6431
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0095 0.0824 0.2858
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0142 0.0522
Schistosoma mansoni valine-tRNA ligase 0.0062 0.0481 0.0481
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0093 0.0323
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0052 0.018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0192 0.1803 1
Onchocerca volvulus 0.002 0.0061 0.0454
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0208 0.1003
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0208 0.0945
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.003 0.0165 0.0573
Echinococcus granulosus nAChR subunit 0.0016 0.0022 0.0022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0064 0.0299
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.017 0.017
Trypanosoma brucei Metacaspase-4 0.0053 0.0398 0.2075
Leishmania major metacaspase, putative 0.0053 0.0398 0.2162
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0097 0.0097
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0398 0.2408
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.017 0.0702
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0208 0.0356
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.003 0.0165 0.0681
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0008
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.0341 0.184
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Toxoplasma gondii thioredoxin reductase 0.0037 0.0228 0.1193
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0015 0.0015
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0876 0.0876
Entamoeba histolytica protein kinase, putative 0.0017 0.003 0.005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0419 0.2347
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0062 0.0481 0.2923
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.7834 0.7834
Entamoeba histolytica hypothetical protein 0.0035 0.021 0.1172
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0142 0.0632
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Echinococcus granulosus intermediate filament protein 0.0033 0.0186 0.0186
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0093 0.0118
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0011 0.0011
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.124 0.124
Schistosoma mansoni carbonic anhydrase-related 0.009 0.0771 0.0771
Onchocerca volvulus 0.0033 0.0186 0.1388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Loa Loa (eye worm) hypothetical protein 0.0089 0.0755 0.2619
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0037 0.0231 0.137
Echinococcus granulosus dnaJ subfamily B 0.0417 0.4089 0.4089
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.0904 0.0904
Echinococcus granulosus nAChR subunit 0.003 0.0165 0.0165
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Echinococcus multilocularis nAChR subunit 0.003 0.0165 0.0165
Leishmania major leucyl-tRNA synthetase, putative 0.0062 0.0481 0.2624
Echinococcus multilocularis protein kinase c iota type 0.0029 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.009 0.0771 0.2672
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.017 0.079
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0471 0.2566
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0104 0.0273
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.003 0.0165 0.0165
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0174 0.162 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.003 0.0165 0.0681
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0097 0.0097
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0398 0.2408
Echinococcus granulosus single minded 2 0.0043 0.0297 0.0297
Trypanosoma brucei metacaspase MCA2 0.0053 0.0398 0.2075
Treponema pallidum leucyl-tRNA synthetase 0.0037 0.0231 0.06
Onchocerca volvulus 0.01 0.0869 0.647
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0223
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0025 0.0105 0.0589
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0061 0.0241
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0142 0.0735
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0142 0.0197
Leishmania major valyl-tRNA synthetase, putative 0.0062 0.0481 0.2624
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0366 0.3573 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0452 0.0452
Leishmania major importin beta-1 subunit, putative 0.0023 0.0086 0.0418
Brugia malayi hypothetical protein 0.0197 0.1858 0.8135
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0484 0.2759
Brugia malayi Cathepsin L-like precursor 0.002 0.0061 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Echinococcus multilocularis caspase 8 0.0053 0.0398 0.0398
Leishmania major cathepsin L-like protease 0.002 0.0061 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Treponema pallidum isoleucyl-tRNA synthetase 0.0174 0.162 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0192 0.1803 0.1803
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Loa Loa (eye worm) hypothetical protein 0.0062 0.0481 0.1668
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.018 0.1685 0.9338
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0271 0.0941
Brugia malayi hypoxia-induced factor 1 0.0182 0.1703 0.7451
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0876 0.0876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.017 0.017
Entamoeba histolytica valyl tRNA synthetase, putative 0.0062 0.0481 0.2871
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.003 0.0165 0.0573
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Leishmania major cathepsin L-like protease 0.002 0.0061 0.0281
Echinococcus multilocularis RNA directed DNA polymerase 0.0077 0.0636 0.0636
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1685 0.4638
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.1855 0.8121
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.017 0.017
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0147 0.135 0.7473
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0799 0.2123
Loa Loa (eye worm) ctsf protein 0.002 0.0061 0.0211
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0208 0.1163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Brugia malayi hypothetical protein 0.0085 0.0723 0.3135
Onchocerca volvulus 0.0137 0.1244 0.927
Plasmodium falciparum carbonic anhydrase 0.009 0.0771 0.1715
Brugia malayi Cathepsin L-like precursor 0.002 0.0061 0.0221
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0064 0.0205
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1685 0.4638
Plasmodium falciparum valine--tRNA ligase, putative 0.0062 0.0481 0.1015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0231 0.0801
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.003 0.0165 0.0681
Chlamydia trachomatis methionine--tRNA ligase 0.0037 0.0231 0.137
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0105
Brugia malayi Importin beta-1 subunit 0.0028 0.0139 0.0566
Brugia malayi MH1 domain containing protein 0.0016 0.0021 0.0044
Onchocerca volvulus 0.0029 0.0153 0.1138
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.003 0.0165 0.0573
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.0774 0.4606
Echinococcus multilocularis nAChR subunit 0.0016 0.0022 0.0022
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0341 0.0341
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0017 0.003 0.003
Echinococcus multilocularis carbonic anhydrase 0.009 0.0771 0.0771
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0662 0.2296
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.002 0.0061 0.0221
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0839 0.0839
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0086 0.0466
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0346 0.12
Trypanosoma cruzi metacaspase, putative 0.0053 0.0398 0.2162
Echinococcus multilocularis smad 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0039 0.0256 0.0256
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0774 0.0774
Schistosoma mansoni isoleucine--tRNA ligase 0.0174 0.162 0.162
Entamoeba histolytica protein kinase, putative 0.0017 0.003 0.005
Toxoplasma gondii Isoleucine-tRNA ligase 0.0025 0.0105 0.0454
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0016 0.0022 0.0051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0021 0.0064 0.0204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.003 0.0165 0.0681
Loa Loa (eye worm) hypothetical protein 0.009 0.0774 0.2684
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0093 0.0323
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0341 0.1749
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0165 0.0681
Loa Loa (eye worm) hypothetical protein 0.0024 0.0104 0.0359
Brugia malayi bZIP transcription factor family protein 0.0083 0.07 0.3037
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0297 0.1262
Echinococcus granulosus protein kinase c epsilon type 0.0031 0.0175 0.0175
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Onchocerca volvulus Cell death protein 3 homolog 0.0103 0.0904 0.6732
Brugia malayi valyl-tRNA synthetase family protein 0.0062 0.0481 0.2071
Schistosoma mansoni carbonic anhydrase 0.009 0.0771 0.0771
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Echinococcus multilocularis carbonic anhydrase 0.009 0.0771 0.0771
Onchocerca volvulus 0.0016 0.0022 0.0167
Brugia malayi Cytochrome P450 family protein 0.0023 0.0093 0.0364
Trypanosoma brucei metacaspase MCA3 0.0053 0.0398 0.2075
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.003 0.0165 0.0165
Schistosoma mansoni serine/threonine kinase 0.0017 0.003 0.003
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0361 0.0361
Echinococcus multilocularis caspase 2 0.0103 0.0904 0.0904
Echinococcus granulosus Protein kinase C brain isozyme 0.0108 0.0955 0.0955
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0484 0.2642
Echinococcus multilocularis X box binding protein 1 0.0279 0.269 0.269
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0052 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Loa Loa (eye worm) hypothetical protein 0.0048 0.0341 0.1181
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0105 0.0589
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0271 0.0271
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0484 0.2943
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0824 0.3583
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1118 0.1118
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1685 0.1685
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0341 0.205
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0052 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Echinococcus multilocularis valyl tRNA synthetase 0.0062 0.0481 0.0481
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0052 0.0179
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0037 0.0231 0.123
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0208 0.1102
Echinococcus granulosus Smad4 0.0016 0.0021 0.0021
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0165 0.0165
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0165 0.0681
Brugia malayi hypothetical protein 0.0065 0.0519 0.2238
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0165 0.0165
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0799 0.2123
Trypanosoma cruzi metacaspase, putative 0.0053 0.0398 0.2162
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0062 0.0481 0.2871
Schistosoma mansoni hypothetical protein 0.0039 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.1703 0.5904
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0662 0.287
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.009 0.0771 0.3347
Trypanosoma brucei trypanothione reductase 0.0037 0.0228 0.1113
Entamoeba histolytica hypothetical protein 0.0035 0.0208 0.1163
Schistosoma mansoni transcription factor btf3 0.0035 0.0208 0.0208
Schistosoma mansoni valine-tRNA ligase 0.0062 0.0481 0.0481
Brugia malayi Thioredoxin reductase 0.0037 0.0228 0.0956
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Echinococcus multilocularis geminin 0.0999 1 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0061 0.0221
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Schistosoma mansoni smad1 5 8 and 0.0016 0.0021 0.0021
Echinococcus granulosus protein kinase c iota type 0.0029 0.015 0.015
Plasmodium falciparum importin beta, putative 0.0028 0.0139 0.0189
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0165 0.0165
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.003 0.003
Echinococcus multilocularis valyl tRNA synthetase 0.0062 0.0481 0.0481
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0484 0.2744
Trypanosoma brucei unspecified product 0.0019 0.0052 0.012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.017 0.079
Schistosoma mansoni lamin 0.0033 0.0186 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0052 0.0183
Entamoeba histolytica hypothetical protein 0.0028 0.0142 0.0751
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.017 0.017
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0097 0.0097
Brugia malayi Cation transporter family protein 0.01 0.0869 0.3778
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0062 0.0481 0.0987
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Plasmodium falciparum leucine--tRNA ligase, putative 0.0062 0.0481 0.1015
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0016 0.0021 0.0065
Leishmania major GTP-binding protein, putative 0.0021 0.0064 0.0299
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1118 0.3876
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.003 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0061 0.0281
Loa Loa (eye worm) hypothetical protein 0.005 0.0365 0.1265
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0097 0.0088
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0662 0.0662
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.021 0.021
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.0771 0.3347
Echinococcus granulosus lamin dm0 0.0033 0.0186 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0165 0.0165
Echinococcus granulosus smad 0.0016 0.0021 0.0021
Toxoplasma gondii cathepsin CPL 0.002 0.0061 0.0185
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0052 0.0255
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.003 0.0105
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0032
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0484 0.2642
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.003 0.003
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.003 0.0105
Schistosoma mansoni hypothetical protein 0.0035 0.021 0.021
Leishmania major DNA polymerase eta, putative 0.0019 0.0052 0.0229
Echinococcus multilocularis cpg binding protein 0.0031 0.017 0.017
Trypanosoma brucei carbonic anhydrase-like protein 0.0192 0.1803 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Schistosoma mansoni cpg binding protein 0.0031 0.017 0.017
Trichomonas vaginalis ran, putative 0.0021 0.0064 0.0334
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0104 0.0518
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0398 0.2223
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0052 0.012
Onchocerca volvulus 0.002 0.0061 0.0454
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0142 0.0677
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0398 0.2163
Leishmania major basic transcription factor 3a, putative 0.0035 0.0208 0.1102
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0484 0.0484
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0361 0.0361
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0021 0.0021
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0142 0.0258
Brugia malayi excitatory GABA receptor EXP-1A 0.003 0.0165 0.0681
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0174 0.162 0.4517
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.021 0.021
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.003 0.0165 0.0681
Plasmodium falciparum thioredoxin reductase 0.0037 0.0228 0.0403
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.017 0.0846
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0025 0.0105 0.0529
Echinococcus granulosus carbonic anhydrase 0.009 0.0771 0.0771
Schistosoma mansoni leucyl-tRNA synthetase 0.0025 0.0105 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0137 0.1244 0.1244
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.0771 0.3347
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0062 0.0481 0.2724
Echinococcus multilocularis caspase 3 0.0088 0.0748 0.0748
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.0771 0.3347
Leishmania major cysteine peptidase A (CPA) 0.002 0.0061 0.0281
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0037 0.0231 0.0231
Echinococcus multilocularis carbonic anhydrase II 0.0192 0.1803 0.1803
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Echinococcus granulosus caspase 0.0141 0.129 0.129
Brugia malayi CHE-14 protein 0.0041 0.0271 0.1147
Schistosoma mansoni hypothetical protein 0.0039 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Chlamydia trachomatis valine--tRNA ligase 0.0062 0.0481 0.2923
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Toxoplasma gondii valyl-tRNA synthetase 0.0062 0.0481 0.2724
Brugia malayi Doublecortin family protein 0.0024 0.0097 0.0382
Brugia malayi RNA binding protein 0.0124 0.1118 0.4876
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0341 0.0341
Echinococcus granulosus GPCR family 2 0.0015 0.0011 0.0011
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0228 0.05
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0233 0.0233
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0297 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0483
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Mycobacterium tuberculosis Possible DNA glycosylase 0.0366 0.3573 1
Schistosoma mansoni single-minded 0.0059 0.0452 0.0452
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0876 0.0876
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Schistosoma mansoni smad 0.0016 0.0021 0.0021
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.002 0.0052
Onchocerca volvulus 0.003 0.0165 0.1231
Brugia malayi Protein kinase domain containing protein 0.0017 0.003 0.0086
Schistosoma mansoni importin beta-1 0.0028 0.0139 0.0139
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.008 0.067 0.2323
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0297 0.0697
Loa Loa (eye worm) hypothetical protein 0.0081 0.0677 0.2348
Brugia malayi MH1 domain containing protein 0.0016 0.0021 0.0044
Onchocerca volvulus 0.0062 0.0481 0.3583
Echinococcus granulosus carbonic anhydrase 0.009 0.0771 0.0771
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0052 0.0229
Schistosoma mansoni Smad4 0.0016 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Brugia malayi Cytochrome P450 family protein 0.0023 0.0093 0.0364
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.003 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0165 0.0165
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0017 0.003 0.0086
Echinococcus granulosus RUN 0.0024 0.0097 0.0097
Loa Loa (eye worm) cysteine protease 0.002 0.0061 0.0211
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0112 0.0994 0.2677
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1118 0.1118
Schistosoma mansoni methionine-tRNA synthetase 0.0037 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.01 0.0869 0.3012
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1118 0.1118
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0208 0.1102
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0021 0.0021
Toxoplasma gondii hypothetical protein 0.009 0.0771 0.4474
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0142 0.037
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.009 0.0771 0.2672
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0038 0.0038
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.017 0.017
Brugia malayi TAR-binding protein 0.0124 0.1118 0.4876
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0078
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0142 0.0258
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0638 0.35
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.003 0.0165 0.0573
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0025 0.0105 0.0529
Schistosoma mansoni leucyl-tRNA synthetase 0.0062 0.0481 0.0481
Brugia malayi hypothetical protein 0.0146 0.1342 0.5865
Schistosoma mansoni lipoxygenase 0.01 0.0867 0.0867
Schistosoma mansoni hypothetical protein 0.0417 0.4089 0.4089
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0179
Schistosoma mansoni cpg binding protein 0.0031 0.017 0.017
Onchocerca volvulus 0.0016 0.0022 0.0167
Echinococcus multilocularis neuropeptide receptor A26 0.0921 0.9216 0.9216
Loa Loa (eye worm) hypothetical protein 0.0077 0.0636 0.2205
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.003 0.0086
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0341 0.1991
Giardia lamblia Valine-tRNA ligase 0.0062 0.0481 0.2738
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0398 0.2408
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0955 0.0955
Onchocerca volvulus 0.002 0.0061 0.0454
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0052 0.0229
Loa Loa (eye worm) hypothetical protein 0.0041 0.0271 0.0941
Loa Loa (eye worm) hypothetical protein 0.0103 0.0904 0.3133
Schistosoma mansoni hypothetical protein 0.0298 0.2884 0.2884
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.003 0.003
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0064 0.0192
Leishmania major protein kinase, putative 0.0016 0.002 0.0052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0061 0.0061
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0037 0.0231 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0398 0.2408
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0638 0.35
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0192 0.1803 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0153 0.053
Loa Loa (eye worm) hypothetical protein 0.009 0.0771 0.2672
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.003 0.0165 0.0165
Echinococcus granulosus caspase 3 0.0088 0.0748 0.0748
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0093 0.0461
Echinococcus granulosus carbonic anhydrase 0.009 0.0771 0.0771
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0174 0.162 0.4307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0398 0.2408
Echinococcus granulosus NDR protein kinase 0.0017 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.009 0.0771 0.3347
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0398 0.2223
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Brugia malayi glutathione reductase 0.0037 0.0228 0.0956
Onchocerca volvulus 0.0033 0.0186 0.1388
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0061 0.0061
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1118 0.3876
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0398 0.2162
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0097 0.0338
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0484 0.2943
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0097
Echinococcus granulosus valyl tRNA synthetase 0.0062 0.0481 0.0481
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0208 0.0722
Echinococcus granulosus X box binding protein 1 0.0279 0.269 0.269
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0186 0.0646
Plasmodium falciparum leucine--tRNA ligase, putative 0.0025 0.0105 0.0108
Loa Loa (eye worm) hypothetical protein 0.0085 0.0723 0.2506
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.003 0.0165 0.0573
Brugia malayi Valyl-tRNA synthetase 0.0062 0.0481 0.2071
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0638 0.35
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.017 0.017
Onchocerca volvulus 0.01 0.0869 0.647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Brugia malayi isoleucyl-tRNA synthetase 0.0174 0.162 0.7088
Onchocerca volvulus 0.0015 0.0011 0.0079
Echinococcus granulosus carbonic anhydrase II 0.0192 0.1803 0.1803
Trypanosoma brucei metacaspase 0.0053 0.0398 0.2075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0052 0.0229
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.018 0.1685 0.1685
Schistosoma mansoni hypothetical protein 0.005 0.0361 0.0361
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0174 0.162 1
Loa Loa (eye worm) GABA receptor subunit 0.0016 0.0022 0.0078
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0705 0.1854
Echinococcus multilocularis transcription factor btf3 0.0035 0.0208 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0061 0.0313
Entamoeba histolytica Ran family GTPase 0.0021 0.0064 0.0263
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0016 0.0022 0.0022
Brugia malayi hypothetical protein 0.0024 0.0097 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0017 0.003 0.003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0011
Echinococcus granulosus RNA directed DNA polymerase 0.0077 0.0636 0.0636
Wolbachia endosymbiont of Brugia malayi valyl-tRNA synthetase 0.0062 0.0481 0.0987
Echinococcus granulosus transcription factor btf3 0.0035 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0279 0.269 0.269
Schistosoma mansoni DNA polymerase eta 0.0019 0.0052 0.0052
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0086 0.0418
Onchocerca volvulus 0.003 0.0165 0.1231
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0105 0.0589
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.129 0.129
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0016 0.0022 0.0051
Leishmania major cathepsin L-like protease 0.0077 0.0638 0.35
Echinococcus granulosus expressed conserved protein 0.009 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0037
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0062 0.0481 0.2624
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0271 0.1619
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0165 0.0165
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0165 0.0681
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.018 0.1685 0.4638
Brugia malayi MH2 domain containing protein 0.0239 0.2281 1
Brugia malayi PAS domain containing protein 0.0059 0.0452 0.1945
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0174 0.162 0.8965
Leishmania major protein kinase, putative 0.0016 0.002 0.0052
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0077 0.0636 0.0636
Echinococcus granulosus lamin 0.0033 0.0186 0.0186
Echinococcus multilocularis expressed conserved protein 0.009 0.0766 0.0766
Loa Loa (eye worm) glutathione reductase 0.0037 0.0228 0.079
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0165 0.0681
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.07 0.07
Trypanosoma brucei protein kinase, putative 0.0062 0.0484 0.256
Brugia malayi RNA, U transporter 1 0.0079 0.0662 0.287
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.0341 0.1842
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.003 0.0165 0.0573
Plasmodium falciparum metacaspase-like protein 0.0053 0.0398 0.0815
Mycobacterium leprae PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI 0.0062 0.0481 0.132
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.022 0.0762
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0142 0.0677
Onchocerca volvulus 0.0037 0.0231 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0398 0.2408
Onchocerca volvulus Putative nachr subunit 0.003 0.0165 0.1231
Echinococcus multilocularis musashi 0.0033 0.0186 0.0186
Schistosoma mansoni jun-related protein 0.0068 0.0542 0.0542
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0484 0.1679
Leishmania major hypothetical protein, conserved 0.0024 0.0104 0.0518
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0165 0.0165
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0052 0.018
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0174 0.162 0.5617
Loa Loa (eye worm) hypothetical protein 0.0037 0.0231 0.0801
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.003 0.0165 0.0165
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0061 0.0061
Plasmodium vivax valine--tRNA ligase, putative 0.0062 0.0481 0.2695
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.003 0.0105
Onchocerca volvulus 0.0146 0.1342 1
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1118 0.1118
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0398 0.2162
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1118 0.4876
Echinococcus multilocularis serine threonine protein kinase 0.0096 0.0835 0.0835
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0341 0.1452
Echinococcus granulosus leucyl tRNA synthetase 0.0062 0.0481 0.0481
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0064 0.0064
Giardia lamblia Isoleucyl-tRNA synthetase 0.0174 0.162 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0228 0.1211
Schistosoma mansoni hypothetical protein 0.0999 1 1
Echinococcus granulosus sodium channel protein 0.0147 0.135 0.135
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.003 0.0165 0.0165
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0061 0.0211
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1302 0.1302
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.003 0.003
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1302 0.1302
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0033 0.0097
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.129 0.129
Schistosoma mansoni patched 1 0.0041 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0146 0.1342 0.4655
Brugia malayi Cell death protein 3 precursor 0.0103 0.0904 0.3933
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.003 0.003
Onchocerca volvulus Cathepsin L homolog 0.002 0.0061 0.0454
Schistosoma mansoni carbonic anhydrase-related 0.009 0.0771 0.0771
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.0396
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0705 0.1948
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0165 0.0681
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0164 0.1519 0.1519
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0484 0.2943
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.003 0.0165 0.0165
Leishmania major cathepsin L-like protease 0.0077 0.0638 0.35
Leishmania major trypanothione reductase 0.0037 0.0228 0.1211
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0093 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0398 0.2408
Schistosoma mansoni nAChR subunit 0.003 0.0165 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0052 0.012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0037
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0062 0.0481 0.2542
Echinococcus granulosus cpg binding protein 0.0031 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.018 0.0625
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0484 0.2642
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0093 0.0355
Echinococcus granulosus caspase 8 0.0053 0.0398 0.0398
Brugia malayi CXXC zinc finger family protein 0.0029 0.0153 0.0626
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0955 0.0955
Chlamydia trachomatis leucine--tRNA ligase 0.0037 0.0231 0.137
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.01 0.0869 0.3012
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0484 0.2642
Schistosoma mansoni cpg binding protein 0.0029 0.0153 0.0153
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0484 0.256
Onchocerca volvulus 0.002 0.0061 0.0454
Brugia malayi hypothetical protein 0.0016 0.0016 0.0022
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.017 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0097 0.0097
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0876 0.3809
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0271 0.0271
Leishmania major cathepsin L-like protease 0.002 0.0061 0.0281
Onchocerca volvulus 0.01 0.0876 0.6522
Loa Loa (eye worm) hypothetical protein 0.0033 0.0191 0.0662
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0228 0.107
Echinococcus granulosus valyl tRNA synthetase 0.0062 0.0481 0.0481
Echinococcus multilocularis leucyl tRNA synthetase 0.0062 0.0481 0.0481
Onchocerca volvulus 0.0065 0.0519 0.3866
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.129 0.129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0033 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.003 0.003
Schistosoma mansoni loxhd1 0.0024 0.0097 0.0097
Onchocerca volvulus 0.0024 0.0097 0.0726
Brugia malayi MH2 domain containing protein 0.0016 0.0021 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0137 0.1244 0.1244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0011 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0052 0.012
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0035 0.021 0.1172
Echinococcus multilocularis cysteine protease 0.002 0.0061 0.0061
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0062 0.0481 0.2871
Echinococcus multilocularis leucyl tRNA synthetase 0.0062 0.0481 0.0481
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0338
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.01 0.0869 0.0869
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0165 0.0681
Schistosoma mansoni intermediate filament proteins 0.0033 0.0186 0.0186
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0486 0.0486
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0824 0.5019
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0035 0.021 0.1172
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.003 0.003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0192 0.1803 0.7896
Echinococcus granulosus leucyl tRNA synthetase 0.0062 0.0481 0.0481
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.003 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Onchocerca volvulus 0.003 0.0165 0.1231
Echinococcus multilocularis protein kinase c epsilon type 0.0031 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0032
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0341 0.0341
Plasmodium falciparum glutathione reductase 0.0037 0.0228 0.0403
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.017 0.0891
Brugia malayi leucyl-tRNA synthetase 0.0062 0.0481 0.2071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.01 0.0871 0.508
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0165 0.0681
Loa Loa (eye worm) carbonic anhydrase 3 0.0192 0.1803 0.6253
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0037 0.0231 0.137
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0086 0.0726 0.2516
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0037 0.0231 0.051
Schistosoma mansoni ran 0.0021 0.0064 0.0064
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0366 0.3573 1
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0174 0.162 0.4454
Onchocerca volvulus 0.0024 0.0097 0.0726
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Onchocerca volvulus Cathepsin L homolog 0.002 0.0061 0.0454
Plasmodium vivax glutathione reductase, putative 0.0037 0.0228 0.107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0174 0.162 0.9608
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.017 0.0891
Plasmodium vivax valine--tRNA ligase, putative 0.0025 0.0105 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0341 0.205
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0104 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0208 0.1228
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0021 0.0072
Brugia malayi Hr1 repeat family protein 0.0017 0.003 0.0086
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.003 0.0105
Toxoplasma gondii tRNA synthetase, putative 0.0062 0.0481 0.2724
Loa Loa (eye worm) LGC-31 protein 0.003 0.0165 0.0573
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0341 0.0341
Brugia malayi Smad1 0.0016 0.0021 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0208 0.1228
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Schistosoma mansoni isoleucine--tRNA ligase 0.0174 0.162 0.162
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.129 0.129
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0093 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0484 0.2943
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0104 0.0518
Loa Loa (eye worm) hypothetical protein 0.0197 0.1858 0.6441
Schistosoma mansoni leucyl-tRNA synthetase 0.0025 0.0105 0.0105
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0484 0.2642
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0208 0.1228
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0174 0.162 1
Brugia malayi MAP kinase sur-1 0.0062 0.0484 0.2086
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0061 0.0313
Leishmania major isoleucyl-tRNA synthetase, putative 0.0174 0.162 0.8976
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0233 0.0233
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.002 0.0052
Echinococcus multilocularis protein patched 0.0041 0.0271 0.0271
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0484 0.2642
Schistosoma mansoni hypothetical protein 0.0068 0.0542 0.0542
Entamoeba histolytica protein kinase, putative 0.0017 0.003 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0052 0.012
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0774 0.0774
Echinococcus granulosus caspase 2 0.0103 0.0904 0.0904
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0824 0.0824
Onchocerca volvulus 0.002 0.0061 0.0454
Brugia malayi Protein kinase c protein 2 0.0092 0.079 0.343
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0108 0.0955 0.0955
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.003 0.0105
Echinococcus multilocularis microtubule associated protein 2 0.068 0.6759 0.6759
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0484 0.0484
Leishmania major cathepsin L-like protease 0.002 0.0061 0.0281
Echinococcus granulosus cathepsin l1 0.002 0.0061 0.0061
Loa Loa (eye worm) ACC-1 protein 0.003 0.0165 0.0573
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0774 0.0774
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0705 0.1854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0052 0.0052
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0142 0.0819
Onchocerca volvulus 0.01 0.0869 0.647
Echinococcus multilocularis carbonic anhydrase 0.009 0.0771 0.0771
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0061 0.0061
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0022 0.0051
Brugia malayi Cation transporter family protein 0.003 0.0165 0.0681
Toxoplasma gondii leucyl-tRNA synthetase 0.0062 0.0481 0.2724
Onchocerca volvulus 0.002 0.0061 0.0454
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.0033 0.0191 0.0191
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0062 0.0481 0.2724
Brugia malayi Cathepsin L-like precursor 0.002 0.0061 0.0221
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0192 0.1803 0.1803
Brugia malayi Protein kinase domain containing protein 0.0017 0.003 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0481 0.2695
Loa Loa (eye worm) hypothetical protein 0.0137 0.1244 0.4315
Schistosoma mansoni smad1 5 8 and 0.0016 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0035 0.021 0.1172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0061 0.0313
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Brugia malayi Isocitrate dehydrogenase 0.0031 0.017 0.0703
Echinococcus granulosus dna polymerase eta 0.0019 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0338
Schistosoma mansoni carbonic anhydrase-related 0.009 0.0771 0.0771
Schistosoma mansoni hypothetical protein 0.0999 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0052 0.012
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.0774 0.0774
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0638 0.3428
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1685 0.1685
Brugia malayi MH2 domain containing protein 0.0016 0.0021 0.0044
Loa Loa (eye worm) RNA binding protein 0.0124 0.1118 0.3876
Brugia malayi hypothetical protein 0.0024 0.0097 0.0382
Schistosoma mansoni ran 0.0021 0.0064 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0341 0.0341
Trichomonas vaginalis AGC family protein kinase 0.0017 0.003 0.0123
Echinococcus granulosus neuropeptide s receptor 0.0921 0.9216 0.9216
Leishmania major cytochrome p450-like protein 0.0023 0.0093 0.0461
Echinococcus granulosus dna polymerase kappa 0.0019 0.0052 0.0052
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0208 0.1075
Leishmania major cathepsin L-like protease 0.0077 0.0638 0.35
Echinococcus granulosus protein kinase C gamma type 0.0096 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.005 0.0361 0.1252
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0341 0.205
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0573
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0824 0.0824
Schistosoma mansoni hypothetical protein 0.0039 0.0256 0.0256
Schistosoma mansoni smad1 5 8 and 0.0016 0.0021 0.0021
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.01 0.0869 0.0869
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.017 0.0891
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.003 0.0165 0.0681
Leishmania major carbonic anhydrase-like protein 0.0192 0.1803 1
Onchocerca volvulus 0.0043 0.0297 0.2214
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0165 0.0681
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0174 0.162 0.7088
Echinococcus granulosus importin subunit beta 1 0.0028 0.0139 0.0139
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0366
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0061 0.0313

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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