Detailed information for compound 1396221

Basic information

Technical information
  • TDR Targets ID: 1396221
  • Name: [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate
  • MW: 334.433 | Formula: C17H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.94 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ncccc1C(=O)OCC(=O)NCCC1=CCCCC1
  • InChi: 1S/C17H22N2O3S/c1-23-16-14(8-5-10-19-16)17(21)22-12-15(20)18-11-9-13-6-3-2-4-7-13/h5-6,8,10H,2-4,7,9,11-12H2,1H3,(H,18,20)
  • InChiKey: KLHZVGIXLHXXTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[2-(1-cyclohexenyl)ethylamino]-2-oxo-ethyl] 2-methylsulfanylpyridine-3-carboxylate
  • 2-(methylthio)-3-pyridinecarboxylic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] ester
  • 2-(methylthio)nicotinic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-keto-ethyl] ester
  • ZINC03468108
  • T5523825

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Importin beta-1 subunit 0.0029 0.0091 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0207 0.0207
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0161 0.0161
Mycobacterium ulcerans hypothetical protein 0.0022 0.0043 0.0175
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0095 0.0189
Brugia malayi Serotonin receptor 0.0039 0.0161 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0179 0.1119 0.2245
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0312 0.0625
Onchocerca volvulus 0.0023 0.0053 0.0025
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0711 0.448
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.0053 0.0213
Plasmodium falciparum metacaspase-like protein 0.0132 0.0793 0.7709
Echinococcus multilocularis snurportin 1 0.031 0.2015 0.2015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0166 0.044
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.054 0.1084
Schistosoma mansoni caspase-7 (C14 family) 0.0254 0.1633 0.2773
Schistosoma mansoni transient receptor potential channel 0.0031 0.0103 0.0175
Echinococcus multilocularis hyperpolarization activated cyclic 0.004 0.0166 0.0166
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0023 0.0053 0.0106
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0031 0.0103 0.0103
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0298 0.28
Echinococcus granulosus fmrfamide receptor 0.0039 0.0161 0.0161
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 1
Echinococcus granulosus caspase 2 0.0254 0.1633 0.1633
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Toxoplasma gondii transporter, cation channel family protein 0.0236 0.1507 1
Schistosoma mansoni caspase-7 (C14 family) 0.0348 0.2275 0.3865
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0091 0.05
Schistosoma mansoni hypothetical protein 0.0449 0.2967 0.504
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0399 0.0967
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0064 0.0281
Echinococcus granulosus microtubule associated protein 2 0.0757 0.508 0.508
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0298 0.1655
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0468 0.2914
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0027 0.007
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0023 0.0053 0.0104
Echinococcus granulosus voltage dependent calcium channel 0.0549 0.3656 0.3656
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0124 0.074 0.074
Schistosoma mansoni cpg binding protein 0.0033 0.012 0.0204
Onchocerca volvulus 0.0039 0.0161 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Schistosoma mansoni hypothetical protein 0.0023 0.0053 0.0089
Brugia malayi hypoxia-induced factor 1 0.0165 0.1024 0.2053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0305 0.0305
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0348 0.2275 0.2275
Leishmania major hypothetical protein, conserved 0.0023 0.0053 0.0467
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0179 0.1119 0.1902
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.014 0.0799
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0161 0.0161
Plasmodium vivax importin-beta 2, putative 0.0029 0.0091 0.0739
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0282 0.2636
Onchocerca volvulus 0.0023 0.0053 0.0025
Leishmania major hypothetical protein, conserved 0.0053 0.0254 0.3058
Echinococcus granulosus tumor protein p63 0.0371 0.2432 0.2432
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0752 0.1278
Leishmania major importin beta-1 subunit, putative 0.0024 0.0053 0.0474
Brugia malayi cation channel family protein 0.0031 0.0103 0.0206
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0103 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0179 0.1119 0.2245
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0166 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0179 0.1119 0.2244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0207 0.0416
Brugia malayi jmjC domain containing protein 0.0033 0.0118 0.0237
Echinococcus granulosus potassium large conductance calcium activated 0.0031 0.0103 0.0103
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.014 0.0799
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Trypanosoma cruzi metacaspase, putative 0.0132 0.0793 0.4558
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0298 0.28
Trichomonas vaginalis glycogen phosphorylase, putative 0.0565 0.3766 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0135 0.0814 0.1383
Mycobacterium leprae conserved hypothetical protein 0.0036 0.014 0.0987
Schistosoma mansoni cpg binding protein 0.0032 0.0108 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.1299 0.2605
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0031 0.0103 0.0206
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0378 0.0758
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0378 0.2333
Echinococcus granulosus phd:f box containing protein 0.0033 0.0118 0.0118
Brugia malayi hypothetical protein 0.0053 0.0254 0.0509
Loa Loa (eye worm) hypothetical protein 0.0053 0.0254 0.0508
Loa Loa (eye worm) hypothetical protein 0.0092 0.0525 0.1052
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0053 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0179 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0236
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.004 0.0166 0.0166
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0254 0.1394
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.1659 0.3326
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0064 0.0128
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.028
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0179 0.1119 0.1119
Onchocerca volvulus 0.0076 0.0411 0.0988
Echinococcus granulosus flap endonuclease 1 0.0029 0.0088 0.0088
Brugia malayi hypothetical protein 0.0111 0.0654 0.1312
Brugia malayi hypothetical protein 0.0039 0.0162 0.0326
Echinococcus multilocularis calcium activated potassium channel variant 0.0023 0.0053 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Brugia malayi jmjC domain containing protein 0.0033 0.0118 0.0237
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0244 0.1567 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0016 0.0043
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0442 0.2923 0.586
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0118 0.0236
Brugia malayi cation channel family protein 0.0031 0.0103 0.0206
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0276
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.014 0.0799
Brugia malayi Probable ClpP-like protease 0.0165 0.1024 0.2054
Loa Loa (eye worm) hypothetical protein 0.0132 0.0793 0.159
Schistosoma mansoni vesicular amine transporter 0.0031 0.0103 0.0175
Echinococcus granulosus TRP transient receptor potential channel 0.0031 0.0103 0.0103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0053 0.0139
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0118 0.0596
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0468 0.0939
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0161 0.0161
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 0.2688
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0135 0.0814 0.1632
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0118 0.0236
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0298 0.0753
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.028
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0161 0.0323
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0092
Trypanosoma cruzi metacaspase, putative 0.0132 0.0793 0.4558
Brugia malayi CXXC zinc finger family protein 0.0032 0.0108 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0348 0.2142
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0031 0.0103 0.0175
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0549 0.3656 0.7331
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0111 0.0654 0.1311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0179 0.1119 0.2244
Schistosoma mansoni jumonji domain containing protein 0.0124 0.074 0.1257
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Echinococcus granulosus lamin 0.003 0.0095 0.0095
Echinococcus multilocularis potassium voltage gated channel protein 0.0031 0.0103 0.0103
Schistosoma mansoni amine GPCR 0.0039 0.0161 0.0273
Schistosoma mansoni lamin 0.003 0.0095 0.0161
Onchocerca volvulus 0.0039 0.0161 0.0316
Brugia malayi olfactory channel protein osm-9 0.0031 0.0104 0.0208
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0031 0.0103 0.0206
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.014 0.0799
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0236
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0092 0.0525 0.0892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0325 0.0553
Mycobacterium tuberculosis Conserved protein 0.0036 0.014 0.0799
Loa Loa (eye worm) ryanodine receptor 0.0031 0.0103 0.0205
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0053 0.0089
Echinococcus multilocularis two pore calcium channel protein 2 0.0031 0.0103 0.0103
Echinococcus multilocularis Ankyrin 0.0016 0.0001 0.0001
Echinococcus granulosus calcium activated potassium channel variant 0.0023 0.0053 0.0053
Echinococcus granulosus shaker cognate 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Echinococcus multilocularis GPCR, family 2 0.0065 0.0337 0.0337
Echinococcus multilocularis potassium channel subfamily K 0.0023 0.0053 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0179 0.1119 0.1902
Mycobacterium ulcerans transmembrane cation transporter 0.0023 0.0053 0.0234
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.0456 0.112
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0312 0.053
Brugia malayi hypothetical protein 0.0023 0.0053 0.0106
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0161 0.0161
Onchocerca volvulus 0.0023 0.0053 0.0025
Loa Loa (eye worm) nuclear hormone receptor 0.0084 0.0471 0.0943
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0161 0.0161
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0254 0.1633 0.3273
Brugia malayi mbt repeat family protein 0.0048 0.0218 0.0438
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1659 0.4405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0031 0.0103 0.0175
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2243
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0161 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0031 0.0103 0.0103
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0108 0.0634 0.6022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Brugia malayi Cell death protein 3 precursor 0.0254 0.1633 0.3274
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.2886 0.5786
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0031 0.0103 0.0206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0207 0.0207
Brugia malayi beta-lactamase family protein 0.0036 0.014 0.0281
Trypanosoma cruzi ion transport protein, putative 0.0023 0.0053 0.0213
Loa Loa (eye worm) hypothetical protein 0.0082 0.0456 0.0913
Onchocerca volvulus 0.0039 0.0161 0.0316
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0161 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1659 0.4405
Echinococcus granulosus voltage gated hydrogen channel 1 0.0031 0.0103 0.0103
Brugia malayi carbohydrate phosphorylase 0.0565 0.3766 0.7551
Schistosoma mansoni voltage-gated ion channel 0.0031 0.0103 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0179 0.1119 0.2244
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0023 0.0053 0.0104
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0118 0.02
Loa Loa (eye worm) nuclear receptor NHR-67 0.0084 0.0471 0.0943
Schistosoma mansoni transient receptor potential channel 4 0.0031 0.0103 0.0175
Onchocerca volvulus 0.0036 0.014 0.026
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0023 0.0053 0.0234
Echinococcus granulosus transient receptor potential gamma protein 0.0031 0.0103 0.0103
Schistosoma mansoni 60S ribosomal protein L21 0.0034 0.0128 0.0218
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0202 0.1275 0.1275
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0161 0.0322
Brugia malayi Transient-receptor-potential like protein 0.0031 0.0103 0.0206
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0023 0.0053 0.0106
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0091 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0054 0.0263 0.0527
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.0471 0.1149
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.014 0.0799
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0161 0.0161
Echinococcus multilocularis caspase 2 0.0254 0.1633 0.1633
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Chlamydia trachomatis endonuclease IV 0.0084 0.0468 0.1205
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0218 0.0371
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0161 0.0273
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0161 0.0323
Brugia malayi intermediate filament protein 0.003 0.0095 0.019
Echinococcus granulosus sodium channel protein 0.0031 0.0103 0.0103
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.0053 0.0213
Brugia malayi beta-lactamase family protein 0.0036 0.014 0.0281
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0086
Brugia malayi GnHR receptor homolog 0.0039 0.0161 0.0323
Echinococcus granulosus calcium activated potassium channel 0.0031 0.0103 0.0103
Echinococcus multilocularis serotonin receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) DR-78 0.0084 0.0471 0.0943
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0711 0.448
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Echinococcus multilocularis nuclear receptor nhr 48 0.0084 0.0471 0.0471
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0084 0.0471 0.08
Schistosoma mansoni neuropeptide receptor 0.0039 0.0161 0.0273
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1478 0.943
Mycobacterium ulcerans endonuclease IV 0.0084 0.0468 0.2914
Toxoplasma gondii exonuclease III APE 0.0059 0.0298 0.1893
Mycobacterium ulcerans hypothetical protein 0.0036 0.014 0.0799
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0092 0.0525 0.1053
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0118 0.1009
Trypanosoma cruzi metacaspase 5, putative 0.0132 0.0793 0.4558
Schistosoma mansoni ap endonuclease 0.0059 0.0298 0.0507
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0031 0.0103 0.1112
Brugia malayi TAR-binding protein 0.0061 0.0312 0.0626
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0053 0.0213
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.014 0.014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0298 0.0698
Mycobacterium ulcerans epimerase 0.0022 0.0043 0.0175
Toxoplasma gondii transporter, cation channel family protein 0.0031 0.0103 0.058
Onchocerca volvulus Protein ultraspiracle homolog 0.0179 0.1119 0.2891
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1114 0.2957
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0004 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.054 0.0918
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0179 0.1119 0.2245
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0549 0.3656 0.3656
Brugia malayi RNA, U transporter 1 0.0083 0.0457 0.0917
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0446 0.0446
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0267 0.1721 1
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1114 0.2957
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.0471 0.0471
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.1299 0.2604
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Leishmania major protein kinase, putative 0.0023 0.005 0.0437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0179 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Plasmodium vivax hypothetical protein, conserved 0.0036 0.014 0.123
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0118 0.02
Echinococcus multilocularis two pore calcium channel protein 1 0.0031 0.0103 0.0103
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0161 0.0322
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Onchocerca volvulus 0.0032 0.0108 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.0471 0.0471
Plasmodium falciparum metacaspase 1 0.0132 0.0793 0.7709
Onchocerca volvulus 0.0039 0.0161 0.0316
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0161 0.0273
Echinococcus multilocularis Glycosyl transferase, family 35 0.0565 0.3766 0.3766
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0031 0.0103 0.0507
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0346 0.2125
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0378 0.2333
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.004 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0471 0.0471
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Schistosoma mansoni voltage-gated cation channel 0.0549 0.3656 0.621
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0301 0.1958 0.3326
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0161 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.007
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Entamoeba histolytica glycogen phosphorylase, putative 0.0244 0.1567 0.4101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0337 0.0337
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0192 0.0192
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0031 0.0103 0.0159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0348 0.2142
Loa Loa (eye worm) beta-lactamase 0.0036 0.014 0.028
Trypanosoma cruzi metacaspase 5, putative 0.0132 0.0793 0.4558
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0161 0.0322
Echinococcus granulosus hyperpolarization activated cyclic 0.004 0.0166 0.0166
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0442 0.2923 0.586
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0207 0.0207
Schistosoma mansoni histamine h1 receptor 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0099 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.007
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0568 0.0964
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.0053 0.0213
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0118 0.0118
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0132 0.0793 0.5213
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0179 0.1119 0.2245
Chlamydia trachomatis glycogen phosphorylase 0.0565 0.3766 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0072 0.0388 0.0388
Mycobacterium ulcerans beta-lactamase 0.0036 0.014 0.0799
Echinococcus granulosus potassium channel subfamily K 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0186 0.1164 0.2333
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0165 0.1024 1
Echinococcus granulosus hypothetical protein 0.0039 0.0161 0.0161
Schistosoma mansoni glycogen phosphorylase 0.0565 0.3766 0.6397
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0549 0.3656 0.3656
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0254 0.1394
Schistosoma mansoni hypothetical protein 0.0065 0.0337 0.0573
Schistosoma mansoni coup transcription factor 0.0179 0.1119 0.1902
Entamoeba histolytica hypothetical protein 0.0039 0.0162 0.0333
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0298 0.0598
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0161 0.0161
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0399 0.1058
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0132 0.0793 0.5213
Echinococcus multilocularis sodium channel protein 0.0062 0.0317 0.0317
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0348 0.2228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0023 0.0053 0.0039
Plasmodium vivax potassium channel, putative 0.0023 0.0053 0.036
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0023 0.0053 0.0106
Schistosoma mansoni nuclear receptor 0.0084 0.0471 0.08
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0298 0.3632
Loa Loa (eye worm) hypothetical protein 0.0122 0.0731 0.1466
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0163 0.0163
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0108 0.0215
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0802 0.5069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0161 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0179 0.1119 0.2244
Schistosoma mansoni zinc finger protein 0.0084 0.0471 0.08
Loa Loa (eye worm) runx1 0.0055 0.0272 0.0545
Brugia malayi beta-lactamase 0.0036 0.014 0.0281
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0348 0.0592
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0179 0.1119 0.1119
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.014 0.0727
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.0103 0.0103
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.0129
Plasmodium vivax hypothetical protein, conserved 0.0132 0.0793 0.7709
Plasmodium falciparum potassium channel 0.0023 0.0053 0.036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.0338 0.0898
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0161 0.0161
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0802 0.7737
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0298 0.0599
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0549 0.3656 0.3656
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0162 0.0162
Loa Loa (eye worm) TWK-28 protein 0.0023 0.0053 0.0104
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0263 0.0263
Schistosoma mansoni retinoic acid receptor RXR 0.0179 0.1119 0.1902
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0088 0.0708
Leishmania major potassium channel subunit-like protein 0.0023 0.0053 0.0467
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0124 0.074 0.074
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0023 0.0053 0.0106
Echinococcus multilocularis short transient receptor potential channel 6 0.0031 0.0104 0.0104
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.014 0.028
Brugia malayi Pre-SET motif family protein 0.0063 0.0325 0.0652
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0202 0.1275 0.2166
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0038 0.0147
Echinococcus granulosus lamin dm0 0.003 0.0095 0.0095
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0854 0.1712
Loa Loa (eye worm) hypothetical protein 0.0092 0.0525 0.1052
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0802 0.5069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0207 0.0352
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0179 0.1119 0.1119
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0128 0.0218
Brugia malayi G-protein coupled receptor 0.0039 0.0161 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.0757 0.508 0.863
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi neuropeptide F receptor 0.0039 0.0161 0.0323
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0161 0.0161
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0023 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0095 0.054 0.1083
Echinococcus multilocularis lysine specific demethylase 5A 0.0124 0.074 0.074
Brugia malayi Nuclear hormone receptor E75 0.0084 0.0471 0.0944
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0023 0.0053 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1659 0.4405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0207 0.0207
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.004 0.0166 0.0282
Brugia malayi PAS domain containing protein 0.0053 0.0258 0.0517
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0399 0.2467
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.004 0.0166 0.0166
Onchocerca volvulus Glycogen phosphorylase homolog 0.0565 0.3766 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0263 0.0263
Onchocerca volvulus 0.0084 0.0471 0.1149
Schistosoma mansoni neuropeptide receptor 0.0039 0.0161 0.0273
Echinococcus multilocularis potassium large conductance calcium activated 0.0031 0.0103 0.0103
Echinococcus granulosus potassium voltage gated channel protein 0.0031 0.0103 0.0103
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0312 0.0626
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0031 0.0103 0.0103
Echinococcus multilocularis caspase 0.0348 0.2275 0.2275
Schistosoma mansoni biogenic amine receptor 0.0039 0.0161 0.0273
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0031 0.0103 0.0206
Trypanosoma cruzi ion transport protein, putative 0.0023 0.0053 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0161 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0793 0.2106
Brugia malayi AKH receptor 0.0039 0.0161 0.0323
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0549 0.3656 0.3656
Loa Loa (eye worm) voltage-dependent calcium channel 0.0236 0.1507 0.3021
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0267 0.1721 1
Echinococcus granulosus potassium voltage gated channel protein 0.0031 0.0103 0.0103
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0348 0.2275 0.2275
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0181
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Schistosoma mansoni single-minded 0.0053 0.0258 0.0438
Onchocerca volvulus 0.0039 0.0161 0.0316
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0023 0.0053 0.0053
Brugia malayi nuclear hormone receptor family member odr-7 0.0084 0.0471 0.0944
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0711 0.448
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2015 0.404
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0161 0.0161
Brugia malayi nuclear receptor RXR 0.0084 0.0471 0.0944
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0263 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0793 0.2106
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.013 0.013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.0456 0.112
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 1
Brugia malayi nuclear receptor NHR-88 0.0179 0.1119 0.2245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0179 0.1119 0.2245
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0118 0.0682
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0161 0.0273
Toxoplasma gondii hypothetical protein 0.0205 0.1296 0.8585
Plasmodium vivax JmjC domain containing protein 0.0033 0.0118 0.1009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.0338 0.0898
Schistosoma mansoni glycogen phosphorylase 0.0565 0.3766 0.6397
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0549 0.3656 0.621
Brugia malayi hypothetical protein 0.0236 0.151 0.3028
Echinococcus granulosus FTZ F1 alpha 0.0179 0.1119 0.1119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.007
Brugia malayi hypothetical protein 0.0034 0.0126 0.0252
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 0.65
Leishmania major metacaspase, putative 0.0132 0.0793 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0023 0.0053 0.0106
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0084 0.0471 0.0943
Brugia malayi steroid hormone receptor 0.0179 0.1119 0.2245
Schistosoma mansoni neuropeptide receptor 0.0039 0.0161 0.0273
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0132 0.0793 0.1347
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0053 0.0053
Schistosoma mansoni sodium/chloride dependent transporter 0.0092 0.0525 0.0892
Schistosoma mansoni hypothetical protein 0.0048 0.0222 0.0377
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.014 0.0281
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0104 0.0104
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.1024 0.2052
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0161 0.0316
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6604 0.6604
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0161 0.0161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0161 0.0161
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.004 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0023 0.0053 0.0089
Echinococcus multilocularis glycogen phosphorylase 0.0565 0.3766 0.3766
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0054 0.0054
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0043 0.0175
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.014 0.0372
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 0.65
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.014 0.0372
Onchocerca volvulus 0.0031 0.0103 0.0159
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0161 0.0323
Brugia malayi Steroid receptor seven-up type 2 0.0179 0.1119 0.2245
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0312 0.0625
Onchocerca volvulus 0.0048 0.0218 0.047
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0161 0.0273
Brugia malayi nuclear hormone receptor 0.0179 0.1119 0.2245
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0039 0.0161 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0179 0.1119 0.2245
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0337 0.0676
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 0.014
Schistosoma mansoni biogenic amine receptor 0.0039 0.0161 0.0273
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0053 0.0089
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0088 0.0133
Onchocerca volvulus 0.0036 0.014 0.026
Brugia malayi Inositol-1 0.0074 0.0399 0.08
Onchocerca volvulus Bile acid receptor homolog 0.0179 0.1119 0.2891
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0793 0.2106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0325 0.0553
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0084 0.0471 0.0471
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0084 0.0471 0.08
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0179 0.1119 0.1119
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0161 0.0161
Toxoplasma gondii hypothetical protein 0.0057 0.0282 0.1783
Schistosoma mansoni cpg binding protein 0.0033 0.012 0.0204
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0179 0.1119 0.1902
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0023 0.0053 0.0106
Onchocerca volvulus 0.0084 0.0471 0.1149
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus serotonin transporter 0.0092 0.0525 0.0525
Brugia malayi tailless protein 0.0084 0.0471 0.0944
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0161 0.0161
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0023 0.0053 0.0053
Schistosoma mansoni importin beta-1 0.0029 0.0091 0.0154
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0031 0.0103 0.0103
Echinococcus multilocularis serotonin transporter 0.0092 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi glutathione reductase 0.0052 0.0251 0.0503
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0549 0.3656 0.3656
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0202 0.1275 0.2166
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0072 0.0388 0.0388
Entamoeba histolytica glycogen phosphorylase, putative 0.0244 0.1567 0.4101
Trypanosoma cruzi metacaspase, putative 0.0132 0.0793 0.4558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0179 0.1119 0.2245
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0161 0.0161
Plasmodium vivax potassium channel, putative 0.0023 0.0053 0.036
Onchocerca volvulus 0.0039 0.0161 0.0316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis potassium voltage gated channel protein 0.0031 0.0103 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0179 0.1119 0.1902
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0207 0.0352
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0053 0.0216
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0298 0.182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0161 0.0273
Leishmania major hypothetical protein, conserved 0.0036 0.014 0.1595
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0399 0.0399
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0031 0.0103 0.0206
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0298 0.182
Echinococcus granulosus tar DNA binding protein 0.0061 0.0312 0.0312
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0348 0.2142
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0471 0.08
Echinococcus granulosus hypothetical protein 0.0031 0.0103 0.0103
Brugia malayi jmjC domain containing protein 0.0033 0.0118 0.0237
Toxoplasma gondii hypothetical protein 0.0031 0.0103 0.058
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0793 0.2106
Onchocerca volvulus 0.0111 0.0653 0.1639
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus caspase 8 0.0132 0.0793 0.0793
Toxoplasma gondii ABC1 family protein 0.0036 0.014 0.0831
Brugia malayi G-protein coupled receptor 0.0039 0.0161 0.0323
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0161 0.0273
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0161 0.0161
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0161 0.0161
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0118 0.0596
Loa Loa (eye worm) solute carrier family 6 member 4 0.0092 0.0525 0.1052
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0161 0.0161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.007
Echinococcus granulosus GPCR family 2 0.0065 0.0337 0.0337
Echinococcus multilocularis serotonin receptor 0.0039 0.0161 0.0161
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0399 0.2244
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0072 0.0388 0.0778
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0254 0.1594
Loa Loa (eye worm) hypothetical protein 0.0236 0.1507 0.3021
Toxoplasma gondii endonuclease IV APN 0.0084 0.0468 0.3032
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0161 0.0161
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0103 0.0103
Brugia malayi Thioredoxin reductase 0.0052 0.0251 0.0503
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0095 0.054 0.054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0222 0.0445
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0325 0.0325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0337 0.0675
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0161 0.0161
Brugia malayi Serotonin receptor 0.0039 0.0161 0.0323
Echinococcus granulosus peptidase Clp S14 family 0.0108 0.0634 0.0634
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0161 0.0161
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Brugia malayi nuclear receptor NHR-67 0.0084 0.0471 0.0944
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) steroid hormone receptor 0.0179 0.1119 0.2244
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0135 0.0814 0.2162
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0337 0.0337
Brugia malayi Cytochrome P450 family protein 0.0057 0.0285 0.0572
Echinococcus granulosus somatostatin receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) uncoordinated protein 58 0.0023 0.0053 0.0104
Mycobacterium leprae Probable lipase LipE 0.0036 0.014 0.0987
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0118 0.0236
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.004 0.0166 0.0332
Brugia malayi mbt repeat family protein 0.0048 0.0218 0.0438
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0179 0.1119 0.2891
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0254 0.2357
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0038 0.0038
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0218 0.0218
Echinococcus granulosus Glycosyl transferase family 35 0.0565 0.3766 0.3766
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0263 0.0528
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.1299 0.2605
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0031 0.0103 0.0507
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0088 0.0419
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0031 0.0103 0.0206
Leishmania major cytochrome p450-like protein 0.0025 0.0064 0.0616
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.0129
Mycobacterium tuberculosis Probable reductase 0.0119 0.0711 0.448
Echinococcus multilocularis lamin dm0 0.003 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0414 0.0703
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0883 0.5945 0.5945
Schistosoma mansoni two-pore calcium channel 0.0031 0.0103 0.0175
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.014 0.0854 0.1711
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Echinococcus multilocularis FTZ F1 alpha 0.0179 0.1119 0.1119
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0179 0.1119 0.2245
Echinococcus granulosus cyclic nucleotide gated cation channel 0.004 0.0166 0.0166
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0378 0.4655
Brugia malayi ion channel NompC 0.0031 0.0103 0.0206
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0161 0.0323
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0161 0.0161
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0118 0.02
Echinococcus granulosus ecdysone induced protein 78C 0.0179 0.1119 0.1119
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0218 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0218 0.0371
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0062 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0325 0.2073
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0161 0.0323
Brugia malayi N-terminal motif family protein 0.0186 0.1164 0.2334
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0179 0.1119 0.1902
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0161 0.0161
Echinococcus multilocularis ecdysone induced protein 78C 0.0179 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0065 0.0337 0.0675
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0161 0.0161
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0059
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0244 0.1567 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.054 0.1083
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0282 0.2636
Loa Loa (eye worm) hypothetical protein 0.0063 0.0325 0.0651
Trichomonas vaginalis set domain proteins, putative 0.0497 0.3299 0.8759
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1659 0.4405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi Cytochrome P450 family protein 0.0025 0.0064 0.0129
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0031 0.0103 0.0175
Schistosoma mansoni myosin xvIII 0.0039 0.0161 0.0273
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0161 0.0273
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0161 0.0161
Echinococcus granulosus allatostatin A receptor 0.0039 0.0161 0.0161
Brugia malayi Dopamine receptor 0.0039 0.0161 0.0323
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0031 0.0103 0.0206
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0165 0.1024 0.1024
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0103 0.0103
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0165 0.1024 0.6762
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0743 0.4987 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0244 0.1567 0.4101
Onchocerca volvulus 0.0023 0.0053 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0031 0.0103 0.0103
Echinococcus granulosus dnaJ subfamily B 0.0449 0.2967 0.2967
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0023 0.0053 0.0106
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0317 0.2016
Echinococcus multilocularis caspase 3 0.0216 0.1374 0.1374
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0793 0.2106
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0399 0.0399
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0023 0.0053 0.0106
Echinococcus granulosus glycogen phosphorylase 0.0565 0.3766 0.3766
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus orexin receptor type 2 0.0039 0.0161 0.0161
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0084 0.0471 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0179 0.1119 0.2245
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0298 0.1655
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0161 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0031 0.0103 0.0175
Echinococcus multilocularis microtubule associated protein 2 0.0757 0.508 0.508
Brugia malayi RNA binding protein 0.0061 0.0312 0.0626
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0471 0.08
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0294 0.0589
Trypanosoma brucei metacaspase 0.0132 0.0793 0.4558
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0161 0.0161
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0161 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Onchocerca volvulus 0.0023 0.0053 0.0025
Onchocerca volvulus 0.0111 0.0653 0.1639
Loa Loa (eye worm) hypothetical protein 0.0236 0.151 0.3027
Loa Loa (eye worm) voltage-gated potassium channel 0.0031 0.0103 0.0205
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0298 0.1655
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0298 0.28
Schistosoma mansoni opsin-like receptor 0.0039 0.0161 0.0273
Echinococcus multilocularis tumor protein p63 0.0371 0.2432 0.2432
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Schistosoma mansoni RAR-like nuclear receptor 0.0179 0.1119 0.1902
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0207 0.0415
Echinococcus granulosus potassium voltage gated channel protein 0.0031 0.0103 0.0103
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0161 0.0273
Onchocerca volvulus 0.0039 0.0161 0.0316
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0348 0.0348
Plasmodium falciparum importin beta, putative 0.0029 0.0091 0.0739
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0251 0.1376
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0095 0.054 0.0918
Brugia malayi Pre-SET motif family protein 0.0437 0.2886 0.5786
Echinococcus multilocularis voltage gated potassium channel 0.0031 0.0103 0.0103
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0165 0.1024 0.6762
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.014 0.0799
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.151 0.151
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0161 0.0323
Schistosoma mansoni hypothetical protein 0.0039 0.0161 0.0273
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0023 0.0053 0.0106
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0057 0.0282 0.2432
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.1659 0.3327
Echinococcus granulosus glycogen phosphorylase 0.0565 0.3766 0.3766
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.014 0.0372
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0023 0.0053 0.0106
Brugia malayi Melibiase family protein 0.0135 0.0814 0.1633
Echinococcus granulosus neuropeptide receptor 0.0039 0.0161 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0179 0.1119 0.2245
Schistosoma mansoni adenoreceptor 0.0039 0.0161 0.0273
Onchocerca volvulus 0.0023 0.0053 0.0025
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0088 0.0232
Echinococcus granulosus sex peptide receptor 0.0039 0.0161 0.0161
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0118 0.02
Schistosoma mansoni lozenge 0.0055 0.0272 0.0462
Echinococcus multilocularis voltage dependent calcium channel 0.0549 0.3656 0.3656
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0088 0.0919
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.0053 0.0213
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0161 0.0273
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0064 0.0309
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1659 0.4405
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.028
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0116 0.0307
Schistosoma mansoni amine GPCR 0.0039 0.0161 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0414 0.0703
Brugia malayi hypothetical protein 0.0122 0.0731 0.1467
Plasmodium falciparum thioredoxin reductase 0.0052 0.0251 0.2328
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.126 0.126
Trypanosoma brucei Metacaspase-4 0.0132 0.0793 0.4558
Brugia malayi nuclear hormone receptor 0.0084 0.0471 0.0944
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1659 0.4405
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0031 0.0103 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0312 0.053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0298 0.0298
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0031 0.0103 0.0103
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0549 0.3656 0.3656
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0202 0.1275 0.2166
Echinococcus granulosus snurportin 1 0.031 0.2015 0.2015
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0346 0.3082
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0312 0.053
Onchocerca volvulus 0.0442 0.2923 0.7736
Toxoplasma gondii thioredoxin reductase 0.0052 0.0251 0.1574
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0118 0.0596
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Schistosoma mansoni biogenic amine receptor 0.0039 0.0161 0.0273
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0084 0.0471 0.0944
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0348 0.2142
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0031 0.0103 0.0206
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0218 0.0218
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0053 0.0213
Echinococcus granulosus twik family of potassium channels 0.0023 0.0053 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0756 0.1514
Echinococcus multilocularis transient receptor potential gamma protein 0.0031 0.0103 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0179 0.1119 0.1119
Brugia malayi hypothetical protein 0.0179 0.1119 0.2244
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0161 0.0161
Echinococcus multilocularis transfer RNA-Gly 0.0031 0.0103 0.0103
Brugia malayi voltage-dependent calcium channel 0.0031 0.0103 0.0206
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0752 0.1278
Plasmodium falciparum glutathione reductase 0.0052 0.0251 0.2328
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) ion channel NompC 0.0031 0.0103 0.0205
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0378 0.0378
Onchocerca volvulus 0.0039 0.0161 0.0316
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.004 0.0166 0.0282
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0192 0.0192
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0091 0.0437
Loa Loa (eye worm) intermediate filament protein 0.003 0.0095 0.0189
Schistosoma mansoni survival motor neuron protein 0.0048 0.0222 0.0377
Echinococcus multilocularis ryanodine receptor 44f 0.0031 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0065 0.0337 0.0573
Brugia malayi hypothetical protein 0.0023 0.0053 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.014 0.0727
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus two pore calcium channel protein 1 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Onchocerca volvulus 0.0039 0.0163 0.032
Echinococcus granulosus short transient receptor potential channel 6 0.0031 0.0103 0.0103
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0399 0.3796
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0298 0.0792
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0282 0.2636
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Schistosoma mansoni steroid hormone receptor ad4bp 0.0179 0.1119 0.1902
Onchocerca volvulus 0.0179 0.1119 0.2891
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0337 0.0676
Schistosoma mansoni ran 0.0021 0.0038 0.0065
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0161 0.0322
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0202 0.1275 0.2166
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0161 0.0161
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0118 0.0682
Onchocerca volvulus 0.003 0.0095 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.028
Entamoeba histolytica hypothetical protein 0.0024 0.0053 0.004
Brugia malayi Nuclear hormone receptor E75 0.0084 0.0471 0.0944
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0161 0.0161
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0399 0.2244
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0325 0.0325
Schistosoma mansoni inositol monophosphatase 0.0074 0.0399 0.0678
Onchocerca volvulus 0.0054 0.0264 0.0592
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0337 0.0337
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0179 0.1119 0.1119
Echinococcus granulosus g protein coupled receptor 0.0039 0.0161 0.0161
Brugia malayi ORL1-like opioid receptor 0.0039 0.0161 0.0323
Echinococcus granulosus lysine specific demethylase 5A 0.0125 0.0752 0.0752
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0118 0.0118
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0031 0.0103 0.0103
Echinococcus multilocularis musashi 0.003 0.0095 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.014 0.0238
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0179 0.1119 0.1902
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.0103 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0179 0.1119 0.1902
Brugia malayi nuclear hormone receptor family member nhr-6 0.0084 0.0471 0.0944
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0023 0.0053 0.0106
Loa Loa (eye worm) inositol-1 0.0074 0.0399 0.0799
Brugia malayi hypothetical protein 0.0084 0.0471 0.0944
Leishmania major hypothetical protein, conserved 0.0031 0.0103 0.1112
Toxoplasma gondii transporter, cation channel family protein 0.0031 0.0103 0.058
Toxoplasma gondii ion channel protein 0.0023 0.0053 0.0244
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0251 0.2328
Brugia malayi hypothetical protein 0.0442 0.2923 0.5861
Leishmania major hypothetical protein, unknown function 0.0031 0.0103 0.1112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Loa Loa (eye worm) glycogen phosphorylase 0.0565 0.3766 0.7551
Echinococcus granulosus intermediate filament protein 0.003 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0088 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0064 0.0128
Trichomonas vaginalis ran, putative 0.0021 0.0038 0.0101
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0181
Echinococcus granulosus hyperpolarization activated cyclic 0.004 0.0166 0.0166
Schistosoma mansoni transient receptor potential channel 0.0031 0.0103 0.0175
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Schistosoma mansoni hypothetical protein 0.0875 0.5887 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Brugia malayi hypothetical protein 0.0084 0.0471 0.0944
Schistosoma mansoni lamin 0.003 0.0095 0.0161
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0053 0.0053
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Echinococcus multilocularis somatostatin receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0064 0.0128
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0161 0.0161
Schistosoma mansoni ap endonuclease 0.0059 0.0298 0.0507
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0099 0.0568 0.0568
Schistosoma mansoni ran 0.0021 0.0038 0.0065
Schistosoma mansoni flap endonuclease-1 0.0026 0.0069 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0166 0.0282
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0031 0.0103 0.0175
Loa Loa (eye worm) TWK-7 protein 0.0023 0.0053 0.0104
Onchocerca volvulus 0.0039 0.0161 0.0316
Onchocerca volvulus 0.0039 0.0161 0.0316
Brugia malayi MH2 domain containing protein 0.0126 0.0756 0.1515
Schistosoma mansoni hypothetical protein 0.0065 0.0337 0.0573
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0711 0.6806
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0161 0.0322
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0264 0.0448
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0161 0.0323
Brugia malayi neuropeptide F receptor 0.0039 0.0161 0.0323
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0711 0.448
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0031 0.0103 0.058
Loa Loa (eye worm) hypothetical protein 0.0084 0.0468 0.0938
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0161 0.0161
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0161 0.0273
Echinococcus granulosus cpg binding protein 0.0033 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0064 0.0281
Brugia malayi photoreceptor-specific nuclear receptor 0.0179 0.1119 0.2245
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.014 0.0372
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Onchocerca volvulus 0.0039 0.0161 0.0316
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0549 0.3656 0.621
Toxoplasma gondii hypothetical protein 0.0031 0.0103 0.058
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Onchocerca volvulus 0.0039 0.0161 0.0316
Brugia malayi ecdysteroid receptor 0.0179 0.1119 0.2245
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0711 0.448
Onchocerca volvulus 0.0039 0.0161 0.0316
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0161 0.0161
Schistosoma mansoni amine GPCR 0.0377 0.2475 0.4204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Echinococcus granulosus small conductance calcium activated potassium 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0118 0.0118
Schistosoma mansoni intermediate filament proteins 0.003 0.0095 0.0161
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0399 0.2567
Leishmania major hypothetical protein, conserved 0.0023 0.0053 0.0467
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0468 0.4484
Brugia malayi Cytochrome P450 family protein 0.0025 0.0064 0.0129
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0031 0.0103 0.0206
Echinococcus granulosus nuclear receptor nhr 48 0.0084 0.0471 0.0471
Onchocerca volvulus 0.0092 0.0525 0.1294
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0312 0.053
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0031 0.0103 0.0206
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.126 0.126
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0165 0.1024 0.2688
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0179 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0161 0.0273
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0118 0.0118
Entamoeba histolytica glycogen phosphorylase, putative 0.0565 0.3766 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0378 0.2333
Loa Loa (eye worm) calcium channel 0.0549 0.3656 0.7331
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0202 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Schistosoma mansoni opsin-like receptor 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi Flap endonuclease-1 0.0029 0.0088 0.0176
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0285 0.0571
Schistosoma mansoni hypothetical protein 0.0875 0.5887 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0254 0.2357
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0023 0.0053 0.0104
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0446 0.0446
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0023 0.0053 0.0106
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1051 0.2708
Brugia malayi G protein-coupled receptor 0.0039 0.0161 0.0323
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0064 0.0281
Echinococcus multilocularis conserved hypothetical protein 0.0031 0.0103 0.0103
Echinococcus granulosus Ankyrin 0.0016 0.0001 0.0001
Toxoplasma gondii Alpha-galactosidase 0.0029 0.0088 0.0479
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Echinococcus multilocularis peptidase Clp (S14 family) 0.0108 0.0634 0.0634
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0161 0.0161
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0023 0.0053 0.0106
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0103 0.0103
Schistosoma mansoni inositol monophosphatase 0.0074 0.0399 0.0678
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0031 0.0103 0.0103
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0179 0.1119 0.2244
Onchocerca volvulus Cell death protein 3 homolog 0.0254 0.1633 0.427
Onchocerca volvulus 0.0039 0.0161 0.0316
Entamoeba histolytica hypothetical protein 0.0039 0.0162 0.0333
Mycobacterium tuberculosis Conserved protein 0.0036 0.014 0.0799
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0166 0.0282
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi hypothetical protein 0.0095 0.054 0.1084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0043 0.0175
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.004 0.0166 0.0166
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0108 0.0634 0.3984
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Schistosoma mansoni glycogen phosphorylase 0.0244 0.1567 0.2662
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0179 0.1119 0.1119
Schistosoma mansoni caspase-3 (C14 family) 0.0348 0.2275 0.3865
Echinococcus multilocularis sodium leak channel non selective protein 0.0031 0.0103 0.0103
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0165 0.1024 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0399 0.1058
Loa Loa (eye worm) hypothetical protein 0.0205 0.1299 0.2604
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0756 0.1514
Leishmania major hypothetical protein, conserved 0.0033 0.0118 0.1309
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0163 0.0944
Loa Loa (eye worm) voltage-gated calcium channel 0.0031 0.0103 0.0205
Trichomonas vaginalis esterase, putative 0.0036 0.014 0.0372
Loa Loa (eye worm) hypothetical protein 0.0205 0.1296 0.2598
Giardia lamblia Glycogen phosphorylase 0.0565 0.3766 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.014 0.0727
Brugia malayi jmjC domain containing protein 0.0124 0.074 0.1483
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0161 0.0322
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.003 0.0095 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0179 0.1119 0.2244
Echinococcus granulosus potassium voltage gated channel protein 0.0031 0.0103 0.0103
Schistosoma mansoni calcium-activated potassium channel 0.0031 0.0103 0.0175
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) serotonin transporter b 0.0092 0.0525 0.1052
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.014 0.0372
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0258 0.0438
Echinococcus granulosus two pore calcium channel protein 2 0.0031 0.0103 0.0103
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Loa Loa (eye worm) hypothetical protein 0.0063 0.0325 0.0651
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0088 0.0419
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0095 0.019
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0132 0.0793 0.1591
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0162 0.0276
Loa Loa (eye worm) hypothetical protein 0.0095 0.054 0.1083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0179 0.1119 0.1119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0179 0.1119 0.2244
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0192 0.0192
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0088 0.0479
Mycobacterium tuberculosis Conserved protein 0.0036 0.014 0.0799
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.0653 0.131
Onchocerca volvulus 0.003 0.0095 0.0138
Loa Loa (eye worm) hypothetical protein 0.0095 0.054 0.1083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0161 0.0316
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0218 0.0371
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0057 0.0281 0.0477
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0135 0.0814 0.1383
Echinococcus multilocularis geminin 0.0875 0.5887 0.5887
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0179 0.1119 0.2245
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0161 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0179 0.1119 0.2245
Echinococcus granulosus thyroid hormone receptor alpha 0.0084 0.0471 0.0471
Echinococcus granulosus caspase 0.0348 0.2275 0.2275
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0088 0.019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 0.014
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0192 0.0325
Onchocerca volvulus 0.0122 0.0731 0.1848
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0202 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0332
Echinococcus granulosus geminin 0.0875 0.5887 0.5887
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Echinococcus multilocularis hyperpolarization activated cyclic 0.004 0.0166 0.0166
Brugia malayi hypothetical protein 0.0095 0.054 0.1084
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.0192 0.0384
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0095 0.054 0.1083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0179 0.1119 0.1902
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0161 0.0161
Echinococcus granulosus importin subunit beta 1 0.0029 0.0091 0.0091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.014 0.0799
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0161 0.0273
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.0471 0.0471
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0366 0.0621
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.2967 0.2967
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0161 0.0273
Trypanosoma brucei metacaspase MCA3 0.0132 0.0793 0.4558
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0016 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0192 0.0325
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0116 0.0307
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0031 0.0103 0.0206
Schistosoma mansoni nuclear receptor 0.0084 0.0471 0.08
Plasmodium vivax metacaspase 1, putative 0.0132 0.0793 0.7709
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0802 0.5069
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Loa Loa (eye worm) hypothetical protein 0.0549 0.3656 0.7331
Echinococcus multilocularis thyroid hormone receptor alpha 0.0179 0.1119 0.1119
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0053 0.0053
Schistosoma mansoni opsin-like receptor 0.0039 0.0161 0.0273
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0166 0.0282
Echinococcus granulosus caspase 3 0.0216 0.1374 0.1374
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0161 0.0322
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.1164 0.301
Schistosoma mansoni hypothetical protein 0.0065 0.0337 0.0573
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0103 0.0175
Leishmania major ion transport protein-like protein 0.0023 0.0053 0.0467
Loa Loa (eye worm) RNA binding protein 0.0061 0.0312 0.0625
Loa Loa (eye worm) MBCTL1 0.0054 0.0263 0.0527
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0165 0.1024 0.1024
Brugia malayi jmjC domain containing protein 0.0033 0.0118 0.0237
Brugia malayi Dopamine receptor protein 2 0.0039 0.0161 0.0323
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0118 0.0118
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0118 0.0118
Schistosoma mansoni nuclear receptor nhr-48 0.0084 0.0471 0.08
Echinococcus granulosus ryanodine receptor 44f 0.0031 0.0103 0.0103
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0072 0.0388 0.0779
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0298 0.28
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.014 0.0799
Onchocerca volvulus 0.0048 0.0222 0.048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0053 0.0089
Onchocerca volvulus 0.0039 0.0161 0.0316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0793 0.2106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0023 0.0053 0.0106
Leishmania major trypanothione reductase 0.0052 0.0251 0.302
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0163 0.0326
Loa Loa (eye worm) hypothetical protein 0.0165 0.1024 0.2053
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0031 0.0103 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0161 0.0161
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0179 0.1119 0.1902
Brugia malayi putative neuropeptide receptor 0.0039 0.0161 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0325 0.0553
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0027 0.007
Treponema pallidum sodium- and chloride- dependent transporter 0.0092 0.0525 0.505
Echinococcus granulosus short transient receptor potential channel 6 0.0031 0.0104 0.0104
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0161 0.0161
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0312 0.0312
Echinococcus granulosus tm gpcr rhodopsin 0.0883 0.5945 0.5945
Schistosoma mansoni hypothetical protein 0.0122 0.0731 0.1242
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0031 0.0103 0.0206
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0218 0.047
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0399 0.4924
Trypanosoma brucei calcium-activated potassium channel, putative 0.0023 0.0053 0.0213
Brugia malayi larval opioid receptor 0.0039 0.0161 0.0323
Trypanosoma brucei metacaspase 5, putative 0.0132 0.0793 0.4558
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0263 0.0263
Plasmodium vivax SET domain protein, putative 0.0063 0.0325 0.3066
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0031 0.0103 0.0175
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0092 0.0525 0.1052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.014 0.0238
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Onchocerca volvulus 0.0023 0.0053 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis transient receptor potential cation channel 0.0031 0.0104 0.0104
Entamoeba histolytica glycogen phosphorylase, putative 0.0565 0.3766 1
Brugia malayi Melatonin receptor type 1A 0.0039 0.0161 0.0323
Plasmodium vivax glutathione reductase, putative 0.0052 0.0251 0.2328
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0016 0.0043
Brugia malayi sulfakinin receptor protein 0.0039 0.0161 0.0323
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0179 0.1119 0.2245
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0118 0.0118
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0161 0.0322
Schistosoma mansoni hypothetical protein 0.014 0.0854 0.1451
Schistosoma mansoni hypothetical protein 0.0039 0.0161 0.0273
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0568 0.0964
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0348 0.0592
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0029 0.0088 0.0149
Echinococcus granulosus g protein coupled receptor 0.0039 0.0161 0.0161
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0298 0.0792
Echinococcus multilocularis sex peptide receptor 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Echinococcus granulosus voltage gated potassium channel 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0179 0.1119 0.2244
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.054 0.1084
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0161 0.0323
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0251 0.1513
Giardia lamblia Hypothetical protein 0.0023 0.0053 0.0097
Schistosoma mansoni hypothetical protein 0.031 0.2015 0.3423
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0251 0.0502
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0263 0.0263
Brugia malayi orphan nuclear receptor NR2E1 0.0084 0.0471 0.0944
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0031 0.0103 0.058
Brugia malayi Nuclear hormone receptor-like 1 0.0179 0.1119 0.2245
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0038 0.0218
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0298 0.0298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Schistosoma mansoni peptidase Clp (S14 family) 0.0165 0.1024 0.174
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.028
Brugia malayi nuclear receptor RXR 0.0095 0.054 0.1084
Trichomonas vaginalis glycogen phosphorylase, putative 0.0565 0.3766 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0053 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.007
Brugia malayi Cyclic-nucleotide gated cation channel 0.004 0.0166 0.0333
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0161 0.0161
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0161 0.0273
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.014 0.0799
Brugia malayi follicle stimulating hormone receptor 0.0743 0.4987 1
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.0104 0.0104
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Loa Loa (eye worm) norepinephrine transporter 0.0092 0.0525 0.1052
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0254 0.2357
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0399 0.2244
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0031 0.0103 0.0103
Echinococcus granulosus cyclic nucleotide gated cation channel 0.004 0.0166 0.0166
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0095 0.054 0.1083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.0411 0.0698
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0468 0.4484
Onchocerca volvulus 0.0039 0.0161 0.0316
Echinococcus multilocularis small conductance calcium activated potassium 0.0023 0.0053 0.0053
Schistosoma mansoni amine GPCR 0.0039 0.0161 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0103 0.0175
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0044 0.0192 0.0383
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0549 0.3656 0.3656
Echinococcus multilocularis lamin 0.003 0.0095 0.0095
Entamoeba histolytica hypothetical protein 0.0039 0.0162 0.0333
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.0437
Echinococcus granulosus sodium leak channel non selective protein 0.0031 0.0103 0.0103
Trypanosoma cruzi metacaspase, putative 0.0132 0.0793 0.4558
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.0471 0.1149
Entamoeba histolytica hypothetical protein 0.0039 0.0162 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1051 0.2791
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0161 0.0273
Loa Loa (eye worm) voltage-gated potassium channel 0.0031 0.0103 0.0205
Brugia malayi Dopamine receptor protein 1 0.0039 0.0161 0.0323
Echinococcus granulosus neuropeptide receptor 0.0039 0.0161 0.0161
Echinococcus granulosus twik family of potassium channels 0.0023 0.0053 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0337 0.0337
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0132 0.0793 0.5213
Onchocerca volvulus 0.0497 0.3299 0.8747
Echinococcus multilocularis caspase 8 0.0132 0.0793 0.0793
Echinococcus granulosus g protein coupled receptor 0.0039 0.0161 0.0161
Brugia malayi hypothetical protein 0.0031 0.0103 0.0206
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0084 0.0471 0.0471
Echinococcus granulosus apoptotic protease activating factor 1 0.0122 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0236
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0254 0.1394
Schistosoma mansoni ryanodine receptor related 0.0031 0.0103 0.0175
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0031 0.0103 0.0103
Toxoplasma gondii melibiase subfamily protein 0.0202 0.1275 0.8446
Onchocerca volvulus 0.0036 0.014 0.026
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0161 0.0161
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.004 0.0166 0.0332
Schistosoma mansoni hypothetical protein 0.0039 0.0161 0.0273
Leishmania major calcium/potassium channel (CAKC), putative 0.0023 0.0053 0.0467
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0325 0.0325
Echinococcus granulosus potassium voltage gated channel protein 0.0031 0.0103 0.0103
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0111 0.0653 0.1309
Onchocerca volvulus 0.0023 0.0053 0.0025
Echinococcus multilocularis cpg binding protein 0.0033 0.012 0.012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0166 0.044
Echinococcus multilocularis short transient receptor potential channel 6 0.0031 0.0103 0.0103
Schistosoma mansoni voltage-dependent calcium channel 0.0031 0.0103 0.0175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0348 0.4275
Echinococcus multilocularis shaker cognate 0.0031 0.0103 0.0103
Brugia malayi nuclear receptor NHR-88 0.0084 0.0471 0.0944
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0752 0.1507
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.014 0.014
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.0943
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0161 0.0161
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0023 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Trypanosoma brucei metacaspase MCA2 0.0132 0.0793 0.4558
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0031 0.0103 0.0159
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0468 0.4331
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0251 0.0251
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0038 0.0129
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0218 0.0437
Schistosoma mansoni transient receptor potential channel 0.0031 0.0104 0.0176
Loa Loa (eye worm) hypothetical protein 0.0054 0.0264 0.0528
Echinococcus multilocularis potassium voltage gated channel protein 0.0031 0.0103 0.0103
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0031 0.0103 0.0175
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0161 0.0273
Schistosoma mansoni neuropeptide receptor 0.0039 0.0161 0.0273
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0031 0.0103 0.0175
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0161 0.0161
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0104
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0095 0.054 0.054
Loa Loa (eye worm) glutathione reductase 0.0052 0.0251 0.0502
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0023 0.0053 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0091 0.0437
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0179 0.1119 0.1119
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0023 0.0053 0.0213
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0179 0.1119 0.1119
Mycobacterium ulcerans lipase LipD 0.0036 0.014 0.0799
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0108 0.0634 0.3984
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0031 0.0103 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0207 0.0352
Plasmodium falciparum flap endonuclease 1 0.0029 0.0088 0.0708
Brugia malayi RE15519p 0.0039 0.0161 0.0323
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0031 0.0103 0.0175
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0118 0.02
Brugia malayi hypothetical protein 0.0039 0.0161 0.0323
Loa Loa (eye worm) hypothetical protein 0.0039 0.0161 0.0322
Echinococcus multilocularis potassium voltage gated channel protein 0.0031 0.0103 0.0103
Leishmania major GTP-binding protein, putative 0.0021 0.0038 0.0283
Echinococcus multilocularis glycogen phosphorylase 0.0565 0.3766 0.3766
Echinococcus granulosus voltage dependent calcium channel 0.0236 0.1507 0.1507
Echinococcus multilocularis voltage dependent calcium channel 0.0549 0.3656 0.3656
Trypanosoma brucei trypanothione reductase 0.0052 0.0251 0.1376
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0399 0.1058
Echinococcus granulosus transient receptor potential cation channel 0.0031 0.0103 0.0103
Echinococcus multilocularis Protein lozenge 0.0055 0.0272 0.0272
Echinococcus granulosus single minded 2 0.0043 0.0188 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0004 0.0009
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0053 0.0053
Brugia malayi jmjC domain containing protein 0.0125 0.0752 0.1508
Mycobacterium ulcerans ion transport protein 0.0023 0.0053 0.0234
Brugia malayi ecdysone receptor 0.0084 0.0471 0.0944
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0161 0.0161
Echinococcus multilocularis calcium activated potassium channel 0.0031 0.0103 0.0103
Brugia malayi conserved hypotetical protein 0.0084 0.0471 0.0944
Echinococcus granulosus serotonin receptor 0.0039 0.0161 0.0161
Echinococcus multilocularis apoptotic protease activating factor 1 0.0122 0.0731 0.0731
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0378 0.0642
Onchocerca volvulus 0.0039 0.0161 0.0316
Schistosoma mansoni amine GPCR 0.0039 0.0161 0.0273
Loa Loa (eye worm) hypothetical protein 0.0205 0.1296 0.2598
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0053 0.0089
Plasmodium falciparum potassium channel 0.0023 0.0053 0.036
Toxoplasma gondii ion channel protein 0.0023 0.0053 0.0244
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0132 0.0793 0.2106
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0043 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0312 0.053

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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