Detailed information for compound 139649

Basic information

Technical information
  • TDR Targets ID: 139649
  • Name: N-[1-[(4-aminoquinazolin-6-yl)methyl]-2-oxopy rrolidin-3-yl]-7-methoxy-N-methylnaphthalene- 2-sulfonamide
  • MW: 491.562 | Formula: C25H25N5O4S
  • H donors: 1 H acceptors: 5 LogP: 2.75 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)cc(cc2)S(=O)(=O)N([C@@H]1CCN(C1=O)Cc1ccc2c(c1)c(N)ncn2)C
  • InChi: 1S/C25H25N5O4S/c1-29(35(32,33)20-7-5-17-4-6-19(34-2)12-18(17)13-20)23-9-10-30(25(23)31)14-16-3-8-22-21(11-16)24(26)28-15-27-22/h3-8,11-13,15,23H,9-10,14H2,1-2H3,(H2,26,27,28)
  • InChiKey: QYAREYZTGPFYKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-[(4-aminoquinazolin-6-yl)methyl]-2-oxo-pyrrolidin-3-yl]-7-methoxy-N-methyl-naphthalene-2-sulfonamide
  • N-[1-[(4-amino-6-quinazolinyl)methyl]-2-oxo-3-pyrrolidinyl]-7-methoxy-N-methyl-2-naphthalenesulfonamide
  • N-[1-[(4-azanylquinazolin-6-yl)methyl]-2-oxo-pyrrolidin-3-yl]-7-methoxy-N-methyl-naphthalene-2-sulfonamide
  • N-[1-[(4-aminoquinazolin-6-yl)methyl]-2-keto-pyrrolidin-3-yl]-7-methoxy-N-methyl-naphthalene-2-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium dependent protein kinase 0.0166 0.0622 0.2207
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0124
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0037
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.1766
Loa Loa (eye worm) hypothetical protein 0.013 0.0473 0.2048
Onchocerca volvulus 0.0059 0.0182 0.4128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0411 0.1622 0.7017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0029
Onchocerca volvulus 0.0081 0.0275 0.6313
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0033 0.0075 0.1098
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0028 0.0056 0.0648
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0008 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.01 0.014
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0017 0.0012 0.0073
Plasmodium vivax calcium-dependent protein kinase, putative 0.0178 0.0668 0.0661
Echinococcus granulosus intermediate filament protein 0.0059 0.0182 0.0642
Plasmodium vivax threonine--tRNA ligase, putative 0.0033 0.0075 0.0068
Brugia malayi MH2 domain containing protein 0.0378 0.149 0.6445
Brugia malayi Smad1 0.0026 0.0047 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Echinococcus granulosus smad 0.0026 0.0047 0.0162
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0028 0.0056 0.0648
Onchocerca volvulus Alhambra homolog 0.0033 0.0076 0.1633
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0028 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0079 0.0336
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0907 0.3925
Schistosoma mansoni histidyl-tRNA synthetase 0.002 0.0022 0.0087
Echinococcus multilocularis smad 0.0026 0.0047 0.0162
Mycobacterium ulcerans pyruvate kinase 0.0039 0.01 0.1603
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0081 0.0275 0.351
Echinococcus granulosus Sugar transporter ERD6 protein 0.0081 0.0275 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0166 0.0714
Plasmodium falciparum pyruvate kinase 0.0039 0.01 0.0093
Schistosoma mansoni hypothetical protein 0.013 0.0473 0.2042
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0023 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0926 0.4
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0249 0.0878
Leishmania major asparaginyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0081 0.0275 0.0972
Schistosoma mansoni cpg binding protein 0.0034 0.008 0.0339
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0033 0.0075 0.0324
Schistosoma mansoni protein kinase 0.0177 0.0667 0.2882
Echinococcus multilocularis muscleblind protein 0.03 0.1167 0.4144
Onchocerca volvulus 0.0034 0.008 0.172
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.011 0.0391 0.5947
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0936 0.3771 0.3767
Brugia malayi Kringle domain containing protein 0.0021 0.0029 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0079 0.0336
Chlamydia trachomatis threonine--tRNA ligase 0.0033 0.0075 0.1193
Brugia malayi MH1 domain containing protein 0.0026 0.0047 0.0204
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.0926 0.4004
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus multilocularis fibrillin 1 0.0016 0.0008 0.0022
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0049 0.0169
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0021 0.0085
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0033 0.0075 0.2114
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0047 0.0162
Schistosoma mansoni transient receptor potential channel 0.0073 0.0241 0.1037
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.01 0.0432
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0034 0.0079 0.0276
Echinococcus granulosus laminin 0.0016 0.0008 0.0022
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0104 0.0452
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0047 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0166 0.0714
Loa Loa (eye worm) hypothetical protein 0.0028 0.0058 0.025
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.011 0.0386
Echinococcus multilocularis dna polymerase eta 0.0019 0.0021 0.007
Echinococcus granulosus bloom syndrome protein 0.0024 0.0041 0.0139
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0203 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Toxoplasma gondii transporter, major facilitator family protein 0.0081 0.0275 0.0404
Echinococcus multilocularis histidyl tRNA synthetase 0.002 0.0022 0.0072
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0129 0.0471 0.2031
Trypanosoma brucei THT1 - hexose transporter, putative 0.018 0.0677 0.8771
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0936 0.3771 0.5677
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.001 0.0029
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0579 0.2312 0.8213
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0021 0.0189
Leishmania major glycyl tRNA synthetase, putative 0.002 0.0022 0.0195
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0033 0.0075 0.0498
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0511 0.7801
Loa Loa (eye worm) hypothetical protein 0.0111 0.0394 0.1706
Echinococcus granulosus global transcription activator snf2l2 0.0068 0.0219 0.0772
Brugia malayi hypothetical protein 0.0081 0.0275 0.1189
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0021 0.0092
Brugia malayi Cam kinase protein 1 0.0177 0.0667 0.2887
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0064 0.0205 0.1449
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0275 0.1183
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0079 0.0946
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0033 0.0075 0.0892
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0113 0.0405 0.1748
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0097 0.0412
Echinococcus granulosus flap endonuclease 1 0.0026 0.0049 0.0169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.0926 0.4004
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0008 0.0033
Giardia lamblia Glycyl-tRNA synthetase 0.0033 0.0075 0.0498
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.0367 0.4718
Loa Loa (eye worm) BRM protein 0.0043 0.0119 0.0513
Echinococcus multilocularis dna repair and recombination protein rad54 0.0017 0.0012 0.0039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.0473 0.1677
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0019 0.0083
Giardia lamblia DINP protein human, muc B family 0.0019 0.0021 0.0105
Brugia malayi T-complex protein 1, beta subunit 0.0028 0.0056 0.0244
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.0473 0.2048
Brugia malayi Muscleblind-like protein 0.03 0.1167 0.5049
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0129 0.0471 0.2036
Brugia malayi hypothetical protein 0.0075 0.0249 0.1075
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0076 0.033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0019 0.0021 0.0086
Giardia lamblia Lysyl-tRNA synthetase 0.0129 0.0471 0.3388
Onchocerca volvulus 0.0103 0.0362 0.8368
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.002 0.0022 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0275 0.1183
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0029
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0064 0.0205 0.2598
Schistosoma mansoni protein kinase 0.0177 0.0667 0.2882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0029 0.0096
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0028 0.0056 0.0362
Onchocerca volvulus 0.0081 0.0275 0.6313
Brugia malayi Latrophilin receptor protein 2 0.013 0.0473 0.2048
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0029 0.0059 0.0689
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0129 0.0471 0.9183
Brugia malayi Major Facilitator Superfamily protein 0.0081 0.0275 0.1189
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.0382 0.1353
Brugia malayi MH2 domain containing protein 0.0026 0.0047 0.0204
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0052 0.0225
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0055 0.0167 0.2092
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0033 0.0075 0.0261
Plasmodium falciparum asparagine--tRNA ligase 0.0019 0.0021 0.0015
Echinococcus multilocularis musashi 0.0059 0.0182 0.0642
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0083
Schistosoma mansoni intermediate filament proteins 0.0059 0.0182 0.0782
Echinococcus granulosus pyruvate kinase 0.002 0.0023 0.0075
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0019 0.0021 0.0106
Brugia malayi Fibulin-1 precursor 0.0016 0.0008 0.0033
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.0382 0.1353
Trypanosoma cruzi hexose transporter 0.018 0.0677 0.8771
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0029 0.0022
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0049 0.0553
Echinococcus multilocularis pyruvate kinase 0.002 0.0023 0.0075
Trichomonas vaginalis sugar transporter, putative 0.018 0.0677 0.2922
Schistosoma mansoni glycyl-tRNA synthetase 0.0033 0.0075 0.0318
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0189
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0034 0.0079 0.0946
Echinococcus multilocularis GPCR, family 2 0.013 0.0473 0.1677
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) histidyl-tRNA synthetase 0.002 0.0022 0.0094
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0023 0.0077
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0016 0.0007 0.0023
Plasmodium vivax proline--tRNA ligase, putative 0.0203 0.077 0.0764
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0029 0.0124
Plasmodium falciparum flap endonuclease 1 0.0026 0.0049 0.0042
Echinococcus multilocularis synaptic vesicle 2 protein 0.0081 0.0275 0.0972
Giardia lamblia Hexose transporter 0.0081 0.0275 0.1958
Plasmodium falciparum hexose transporter 0.0579 0.2312 0.2306
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.007 0.0305
Brugia malayi Sugar transporter family protein 0.0081 0.0275 0.1189
Chlamydia trachomatis lysine--tRNA ligase 0.0129 0.0471 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0079 0.0946
Echinococcus granulosus pyruvate kinase 0.002 0.0023 0.0075
Onchocerca volvulus 0.01 0.0352 0.8123
Echinococcus granulosus disco interacting protein 2 0.0039 0.0101 0.0352
Echinococcus granulosus transient receptor potential ion channel A 0.0107 0.0379 0.1343
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0275 0.1183
Toxoplasma gondii aspartate-tRNA ligase 0.0019 0.0021 0.0022
Leishmania major hypothetical protein, conserved 0.0104 0.0367 0.4718
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0166 0.0714
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0081 0.0275 1
Echinococcus multilocularis calcium dependent protein kinase 0.0166 0.0622 0.2207
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0016 0.0007 0.0023
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0023 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0177 0.0667 0.2367
Schistosoma mansoni Smad4 0.0026 0.0047 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0115 0.0493
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Toxoplasma gondii sugar transporter ST2 0.0081 0.0275 0.0404
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0081 0.0275 0.5183
Loa Loa (eye worm) T-complex protein 1 0.0028 0.0056 0.0244
Loa Loa (eye worm) sugar transporter 0.0081 0.0275 0.1189
Echinococcus granulosus solute carrier family 22 0.0081 0.0275 0.0972
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0132 0.0465
Schistosoma mansoni sugar transporter 0.0081 0.0275 0.1183
Trypanosoma brucei unspecified product 0.0019 0.0021 0.0189
Giardia lamblia Threonyl-tRNA synthetase 0.0033 0.0075 0.0498
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.001 0.0004
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0177 0.0667 0.865
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0037
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.002 0.0079
Schistosoma mansoni hypothetical protein 0.0047 0.0132 0.0567
Echinococcus granulosus SPRY domain containing protein 0.0017 0.0012 0.0038
Schistosoma mansoni survival motor neuron protein 0.01 0.0352 0.1516
Schistosoma mansoni lamin 0.0059 0.0182 0.0782
Loa Loa (eye worm) sugar transporter 0.0579 0.2312 1
Echinococcus granulosus solute carrier family 22 0.0081 0.0275 0.0972
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Schistosoma mansoni hypothetical protein 0.013 0.0473 0.2042
Echinococcus granulosus pyruvate kinase 0.0039 0.01 0.0349
Plasmodium vivax CDK-related protein kinase 6, putative 0.2459 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0064 0.0205 0.2598
Loa Loa (eye worm) hypothetical protein 0.012 0.0431 0.1866
Schistosoma mansoni glucose transport protein 0.0579 0.2312 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0033 0.0075 0.0261
Trichomonas vaginalis sugar transporter, putative 0.018 0.0677 0.2922
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0064 0.0205 0.2598
Echinococcus granulosus cpg binding protein 0.0034 0.008 0.0278
Echinococcus granulosus short transient receptor potential channel 6 0.0073 0.0241 0.0852
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0064 0.0205 0.2598
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0059 0.0251
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus multilocularis SPRY domain containing protein 0.0017 0.0012 0.0038
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0129 0.0471 0.6074
Brugia malayi Disco-interacting protein 2 homolog 0.0039 0.0101 0.0435
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0054
Echinococcus granulosus synaptic vesicle 2 protein 0.0081 0.0275 0.0972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.011 0.0391 0.7624
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0016 0.0007 0.0019
Plasmodium vivax asparagine--tRNA ligase, putative 0.0019 0.0021 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0021 0.007
Loa Loa (eye worm) BRM protein 0.0035 0.0085 0.0368
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0203 0.077 1
Trypanosoma brucei glucose transporter 2A 0.018 0.0677 0.8771
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0059 0.1044
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0052 0.0329
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0034 0.0079 0.0335
Trypanosoma brucei glucose transporter 1E 0.018 0.0677 0.8771
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.001 0.0056
Onchocerca volvulus 0.0081 0.0275 0.6313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0034 0.0079 0.0946
Trichomonas vaginalis glucose transporter, putative 0.018 0.0677 0.2922
Trypanosoma brucei DNA repair and recombination protein RAD54, putative 0.0017 0.0012 0.0073
Leishmania major aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0019 0.0021 0.0093
Echinococcus multilocularis solute carrier family 22 0.0081 0.0275 0.0972
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0021 0.0092
Mycobacterium ulcerans hypothetical protein 0.0029 0.0059 0.0781
Schistosoma mansoni hypothetical protein 0.013 0.0473 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0205 0.0882
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Leishmania major hypothetical protein, conserved 0.0029 0.0059 0.0689
Echinococcus multilocularis short transient receptor potential channel 6 0.0073 0.0241 0.0852
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0249 0.0878
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0178 0.0668 0.0997
Plasmodium falciparum glycine--tRNA ligase 0.002 0.0022 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0079 0.0342
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Echinococcus granulosus solute carrier family 22 0.0081 0.0275 0.0972
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0033
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0047 0.0162
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0064 0.0205 0.1449
Brugia malayi BRM protein 0.0068 0.0219 0.0947
Mycobacterium ulcerans sugar transporter 0.0081 0.0275 0.5183
Brugia malayi FAT domain containing protein 0.0015 0.0002 0.0007
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0079 0.0336
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0029
Loa Loa (eye worm) 63kd antigen 0.0019 0.0021 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Loa Loa (eye worm) phosphatidylinositol 3 0.0034 0.0079 0.0342
Schistosoma mansoni hypothetical protein 0.0075 0.0249 0.1069
Echinococcus multilocularis global transcription activator snf2l2 0.0068 0.0219 0.0772
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0177 0.0667 0.2882
Schistosoma mansoni glucose transport protein 0.0579 0.2312 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0178 0.0668 0.0661
Plasmodium falciparum threonine--tRNA ligase 0.0033 0.0075 0.0068
Loa Loa (eye worm) hypothetical protein 0.0103 0.0362 0.1567
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0033 0.0075 0.0324
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0174 0.0653 0.2315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0205 0.0882
Onchocerca volvulus 0.0081 0.0275 0.6313
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0047 0.0197
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0008 0.0001
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0008 0.0033
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0046 0.0508
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0034 0.0079 0.0276
Brugia malayi Sugar transporter family protein 0.0579 0.2312 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0926 0.3285
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0182 0.0788
Plasmodium falciparum DNA repair and recombination protein RAD54, putative 0.0017 0.0012 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0128 0.0546
Plasmodium falciparum asparagine--tRNA ligase 0.0019 0.0021 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0431 0.1861
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0019 0.0019 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0504
Trichomonas vaginalis glucose transporter, putative 0.0081 0.0275 0.1183
Schistosoma mansoni hypothetical protein 0.036 0.1414 0.6117
Loa Loa (eye worm) hypothetical protein 0.0281 0.109 0.4717
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Schistosoma mansoni glucose transport protein 0.0579 0.2312 1
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0275 0.1183
Brugia malayi hypothetical protein 0.0104 0.0367 0.1588
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0041 0.0139
Schistosoma mansoni sugar transporter 0.0081 0.0275 0.1183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0504
Brugia malayi PHD-finger family protein 0.0033 0.0076 0.033
Loa Loa (eye worm) hypothetical protein 0.0411 0.1622 0.7017
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0028 0.0056 0.0195
Onchocerca volvulus 0.0081 0.0275 0.6313
Entamoeba histolytica hypothetical protein 0.0129 0.0471 0.3388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0166 0.0714
Loa Loa (eye worm) pyruvate kinase 0.0039 0.01 0.0432
Toxoplasma gondii facilitative glucose transporter GT1 0.0579 0.2312 0.3476
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0023 0.0016
Echinococcus granulosus Tolloid protein 1 0.0016 0.0008 0.0022
Chlamydia trachomatis histidine--tRNA ligase 0.002 0.0022 0.0008
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0079 0.0335
Leishmania major myo-inositol/proton symporter (MIT) 0.0081 0.0275 0.351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0205 0.0888
Echinococcus multilocularis cpg binding protein 0.0034 0.008 0.0278
Echinococcus granulosus pyruvate kinase 0.002 0.0023 0.0075
Echinococcus multilocularis serine protein kinase ATM 0.0034 0.0079 0.0275
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0033 0.0075 0.0324
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.002 0.0022 0.0195
Trypanosoma cruzi hexose transporter, putative 0.018 0.0677 0.8771
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0352 0.1522
Echinococcus multilocularis disco interacting protein 2 0.0039 0.0101 0.0352
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0367 0.4718
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0174 0.0653 0.2315
Giardia lamblia Prolyl-tRNA synthetase 0.0174 0.0653 0.4717
Echinococcus multilocularis lysyl tRNA synthetase 0.0129 0.0471 0.1668
Echinococcus multilocularis lamin dm0 0.0059 0.0182 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.001 0.0004
Plasmodium falciparum histidine--tRNA ligase, putative 0.002 0.0022 0.0015
Trichomonas vaginalis glucose transporter, putative 0.018 0.0677 0.2922
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0021 0.0189
Onchocerca volvulus Arrow homolog 0.0016 0.0008 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0079 0.0341
Echinococcus granulosus lamin 0.0059 0.0182 0.0642
Echinococcus multilocularis Smad4 0.0026 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Brugia malayi Aspartyl-tRNA synthetase 0.0019 0.0021 0.0093
Giardia lamblia Pyruvate kinase 0.0039 0.01 0.0678
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0061 0.0193 0.3505
Giardia lamblia PHD finger protein 15 0.0033 0.0076 0.0506
Echinococcus multilocularis short transient receptor potential channel 6 0.0073 0.0241 0.0852
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0039 0.0101 0.0429
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0076 0.0105
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0351 0.1376 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0054
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0021 0.007
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Giardia lamblia GTOR 0.0064 0.0205 0.1449
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.002 0.0022 0.0087
Echinococcus granulosus dna polymerase eta 0.0019 0.0021 0.007
Schistosoma mansoni protein kinase 0.0177 0.0667 0.2882
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0178 0.0668 0.0661
Leishmania major protein kinase, putative 0.0177 0.0667 0.865
Loa Loa (eye worm) hypothetical protein 0.0059 0.0182 0.0788
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0037
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0033 0.0075 0.1055
Schistosoma mansoni lamin 0.0059 0.0182 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Brugia malayi hypothetical protein 0.0067 0.0216 0.0936
Schistosoma mansoni transient receptor potential channel 0.0073 0.0241 0.1037
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0033 0.0075 0.0892
Echinococcus multilocularis laminin 0.0016 0.0008 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0205 0.0882
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0033
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0076 0.0265
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.001 0.0029
Schistosoma mansoni hypothetical protein 0.0021 0.0029 0.0117
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.01 0.1844
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Leishmania major glucose transporter/membrane transporter D2, putative 0.018 0.0677 0.8771
Plasmodium falciparum calcium-dependent protein kinase 2 0.0178 0.0668 0.0661
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Treponema pallidum glycyl-tRNA synthetase 0.002 0.0022 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1106 0.8031
Schistosoma mansoni lysyl-tRNA synthetase 0.0129 0.0471 0.2031
Plasmodium falciparum aspartate--tRNA ligase 0.0019 0.0021 0.0015
Schistosoma mansoni cpg binding protein 0.0034 0.008 0.0339
Echinococcus multilocularis geminin 0.036 0.1414 0.5023
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0174 0.0653 0.2823
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.011 0.0386
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.002 0.0022 0.0195
Schistosoma mansoni transient receptor potential channel 4 0.0111 0.0394 0.1701
Schistosoma mansoni sugar transporter 0.0081 0.0275 0.1183
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.01 0.2188
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0667 0.2882
Loa Loa (eye worm) major facilitator superfamily transporter 0.0081 0.0275 0.1189
Schistosoma mansoni transient receptor potential channel 0.0111 0.0394 0.1701
Onchocerca volvulus 0.0081 0.0275 0.6313
Echinococcus granulosus dna repair and recombination protein rad54 0.0017 0.0012 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0504
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0064 0.0205 0.0724
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0324
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0052 0.0597
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.01 0.1216
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.002 0.0022 0.0087
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0033 0.0075 0.0498
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.0367 0.036
Onchocerca volvulus 0.0081 0.0275 0.6313
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0008 0.0033
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0033 0.0075 0.1098
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.01 0.2188
Giardia lamblia TCP-1 chaperonin subunit beta 0.0028 0.0056 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Onchocerca volvulus 0.0081 0.0275 0.6313
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0021 0.0085
Loa Loa (eye worm) hypothetical protein 0.0122 0.044 0.1904
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Loa Loa (eye worm) type III restriction enzyme 0.0017 0.0012 0.0054
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0021 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0166 0.0714
Schistosoma mansoni helicase 0.0068 0.0219 0.094
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0033 0.0075 0.0892
Loa Loa (eye worm) pyruvate kinase 0.0039 0.01 0.0432
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0041 0.0169
Echinococcus multilocularis solute carrier family 22 0.0081 0.0275 0.0972
Plasmodium falciparum calcium-dependent protein kinase 3 0.0178 0.0668 0.0661
Brugia malayi Trypsin family protein 0.012 0.0431 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0079 0.0336
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0023 0.0093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0021 0.0286
Brugia malayi Bromodomain containing protein 0.0035 0.0084 0.0361
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.011 0.0391 0.7624
Echinococcus multilocularis solute carrier family 22 0.0081 0.0275 0.0972
Entamoeba histolytica protein kinase rad3, putative 0.0019 0.0019 0.009
Echinococcus granulosus serine protein kinase ATM 0.0034 0.0079 0.0275
Trypanosoma cruzi histidyl-tRNA synthetase 0.002 0.0022 0.0195
Echinococcus granulosus glycyl tRNA synthetase 0.0033 0.0075 0.0261
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0071 0.0234 0.101
Leishmania major glucose transporter, lmgt3 0.018 0.0677 0.8771
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus granulosus SPRY domain containing protein 0.0017 0.0012 0.0038
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0177 0.0667 0.2887
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0021 0.0085
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Giardia lamblia Aspartyl-tRNA synthetase 0.0019 0.0021 0.0106
Brugia malayi Isocitrate dehydrogenase 0.0017 0.001 0.0042
Entamoeba histolytica protein kinase, putative 0.0177 0.0667 0.4824
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0023 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Schistosoma mansoni pyruvate kinase 0.0039 0.01 0.0425
Loa Loa (eye worm) hypothetical protein 0.0039 0.01 0.0432
Brugia malayi Calcitonin receptor-like protein seb-1 0.0411 0.1622 0.7017
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0174 0.0653 0.2819
Echinococcus granulosus SPRY domain containing protein 0.0017 0.0012 0.0038
Echinococcus multilocularis solute carrier family 22 0.0081 0.0275 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0007 0.0023
Plasmodium vivax hexose transporter 0.0579 0.2312 0.2306
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0009 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0503
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0056 0.0237
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0104 0.0366
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0059 0.0689
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0029 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0104 0.0367 0.1588
Brugia malayi Major Facilitator Superfamily protein 0.0081 0.0275 0.1189
Leishmania major threonyl-tRNA synthetase, putative 0.0033 0.0075 0.0892
Echinococcus multilocularis pyruvate kinase 0.0031 0.0066 0.0231
Echinococcus granulosus geminin 0.036 0.1414 0.5023
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0203 0.077 0.1152
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Brugia malayi Flap endonuclease-1 0.0026 0.0049 0.0212
Giardia lamblia Sugar-proton symporter 0.0081 0.0275 0.1958
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0023 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0029 0.0286
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.01 0.0432
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0029 0.0059 0.0689
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0028 0.0056 0.005
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0017 0.0012 0.0047
Echinococcus multilocularis pyruvate kinase 0.002 0.0023 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Toxoplasma gondii FATC domain-containing protein 0.0034 0.0079 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0019 0.0076
Echinococcus granulosus pyruvate kinase 0.0039 0.01 0.0349
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0231
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0019 0.0021 0.0093
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0029 0.0059 0.0689
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0034 0.0079 0.0943
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.0473 0.1677
Onchocerca volvulus 0.0081 0.0275 0.6313
Trypanosoma brucei histidyl-tRNA synthetase 0.002 0.0022 0.0195
Brugia malayi recombination factor GdRad54 0.0017 0.0012 0.0054
Brugia malayi lysyl-tRNA synthetase 0.0129 0.0471 0.2036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0172 0.0745
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0081 0.0275 0.5183
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0049 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0033 0.0075 0.0324
Loa Loa (eye worm) transcription factor SMAD2 0.0378 0.149 0.6445
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0411
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0029 0.0096
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0049 0.0064
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0021 0.0286
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.001 0.0037
Toxoplasma gondii protein kinase, putative 0.1637 0.6637 1
Schistosoma mansoni sugar transporter 0.0081 0.0275 0.1183
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0017 0.0012 0.0073
Brugia malayi MH1 domain containing protein 0.0026 0.0047 0.0204
Giardia lamblia Pyruvate kinase 0.002 0.0023 0.0116
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0019 0.0019 0.0063
Echinococcus multilocularis survival motor neuron protein 1 0.0492 0.1952 0.6934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0926 0.4
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0079 0.0336
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0129 0.0471 0.9183
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0033 0.0075 0.0318
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0019 0.0019 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0579 0.2312 1
Echinococcus multilocularis SPRY domain containing protein 0.0017 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0174 0.0653 0.2823
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) pyruvate kinase 0.0039 0.01 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0092
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0178 0.0668 0.0661
Brugia malayi intermediate filament protein 0.0059 0.0182 0.0788
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0058 0.02
Echinococcus granulosus Threonyl tRNA synthetase C 0.0033 0.0075 0.0261
Plasmodium falciparum pyruvate kinase 2 0.002 0.0023 0.0016
Toxoplasma gondii t-complex protein beta subunit 0.0028 0.0056 0.0075
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0174 0.0653 0.2823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0503
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0021 0.007
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.0367 0.0543
Schistosoma mansoni egf-like domain protein 0.0016 0.0008 0.0026
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0008 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0249 0.1069
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0008 0.0033
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Mycobacterium ulcerans histidyl-tRNA synthetase 0.002 0.0022 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0219 0.0949
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0047 0.0162
Trichomonas vaginalis sugar transporter, putative 0.018 0.0677 0.2922
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0097 0.0412
Schistosoma mansoni pyruvate kinase 0.002 0.0023 0.0092
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0182 0.0788
Loa Loa (eye worm) hypothetical protein 0.0058 0.0178 0.0769
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0129 0.0471 0.7182
Brugia malayi CXXC zinc finger family protein 0.0034 0.008 0.0346
Treponema pallidum prolyl-tRNA synthetase 0.0061 0.0193 0.158
Echinococcus multilocularis muscleblind protein 1 0.03 0.1167 0.4144
Echinococcus granulosus dna polymerase kappa 0.0019 0.0021 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0225
Leishmania major modification methylase-like protein 0.002 0.0023 0.0213
Onchocerca volvulus 0.0081 0.0275 0.6313
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0034 0.0079 0.0336
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Plasmodium falciparum lysine--tRNA ligase 0.0129 0.0471 0.0464
Plasmodium falciparum calcium-dependent protein kinase 4 0.0178 0.0668 0.0661
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0049 0.0308
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0132 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Onchocerca volvulus 0.0081 0.0275 0.6313
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0058 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0021 0.0092
Toxoplasma gondii hypothetical protein 0.0085 0.0291 0.0428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0203 0.077 1
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.002 0.0022 0.0022
Schistosoma mansoni lysyl-tRNA synthetase 0.0129 0.0471 0.2031
Trypanosoma cruzi hexose transporter, putative 0.018 0.0677 0.8771
Echinococcus multilocularis 0.0017 0.0012 0.0039
Echinococcus multilocularis General substrate transporter 0.0498 0.1978 0.7028
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0323
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0081 0.0275 0.532
Entamoeba histolytica DNA repair protein, putative 0.0017 0.0012 0.0041
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Echinococcus multilocularis calcium activated potassium channel 0.0015 0.0002 0.0002
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0023 0.0016
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0177 0.0667 0.2367
Echinococcus granulosus General substrate transporter 0.0498 0.1978 0.7028
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0059 0.0251
Chlamydia trachomatis pyruvate kinase 0.0039 0.01 0.1744
Schistosoma mansoni smad 0.0026 0.0047 0.0197
Plasmodium falciparum phd finger protein, putative 0.0033 0.0076 0.0069
Trypanosoma cruzi hexose transporter, putative 0.018 0.0677 0.8771
Leishmania major glucose transporter, lmgt2 0.018 0.0677 0.8771
Echinococcus granulosus Smad4 0.0026 0.0047 0.0162
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0064 0.0205 0.0724
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0076 0.0069
Plasmodium vivax DNA repair protein RAD54, putative 0.0017 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0511 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Leishmania major DNA polymerase eta, putative 0.0019 0.0021 0.0189
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.1766
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1106 0.8031
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0033 0.0075 0.0103
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0064 0.0205 0.2598
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Leishmania major glucose transporter, lmgt1 0.018 0.0677 0.8771
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0019 0.0021 0.007
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0067 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Plasmodium falciparum proline--tRNA ligase 0.0203 0.077 0.0764
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0029 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Brugia malayi isocitrate dehydrogenase 0.0017 0.001 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0034 0.0079 0.0943
Leishmania major hypothetical protein, conserved 0.0081 0.0275 0.351
Leishmania major aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Entamoeba histolytica DNA repair protein, putative 0.0017 0.0012 0.0041
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0023 0.0119
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0064 0.0205 0.0882
Loa Loa (eye worm) hypothetical protein 0.012 0.0431 0.1866
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0059 0.0815
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0174 0.0653 0.2819
Echinococcus granulosus peregrin 0.0035 0.0084 0.0291
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0008 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0028 0.0114
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0367 0.4718
Plasmodium falciparum mitogen-activated protein kinase 2 0.0936 0.3771 0.3767
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0129 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0275 0.1183
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.1766
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0047 0.0162
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0029 0.0022
Loa Loa (eye worm) Smad1 0.0026 0.0047 0.0204
Onchocerca volvulus 0.0081 0.0275 0.6313
Echinococcus multilocularis transient receptor potential gamma protein 0.0111 0.0394 0.1397
Echinococcus granulosus short transient receptor potential channel 6 0.0073 0.0241 0.0852
Brugia malayi Transient-receptor-potential like protein 0.0041 0.011 0.0476
Brugia malayi T-complex protein 1, beta subunit 0.0028 0.0056 0.0244
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0033
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.001 0.0037
Treponema pallidum threonyl-tRNA synthetase 0.0033 0.0075 0.0494
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0034 0.0079 0.0946
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Plasmodium vivax histidine--tRNA ligase, putative 0.002 0.0022 0.0015
Echinococcus granulosus histidyl tRNA synthetase 0.002 0.0022 0.0072
Echinococcus granulosus calcium activated potassium channel 0.0015 0.0002 0.0002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0021 0.007
Brugia malayi jmjC domain containing protein 0.004 0.0104 0.0452
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0029
Schistosoma mansoni smad1 5 8 and 0.0026 0.0047 0.0197
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0292 0.1256
Onchocerca volvulus 0.0039 0.0101 0.2208
Echinococcus granulosus transient receptor potential gamma protein 0.0111 0.0394 0.1397
Loa Loa (eye worm) hypothetical protein 0.0492 0.1952 0.8445
Onchocerca volvulus 0.0106 0.0377 0.8714
Plasmodium vivax asparagine--tRNA ligase, putative 0.0019 0.0021 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0107 0.0454
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0016 0.0007 0.0023
Echinococcus multilocularis 0.0017 0.0012 0.0038
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0056 0.0237
Loa Loa (eye worm) hypothetical protein 0.007 0.0226 0.0978
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0041 0.0176
Toxoplasma gondii sugar transporter ST3 0.0081 0.0275 0.0404
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0033 0.0075 0.1352
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0677 0.2922
Brugia malayi hypothetical protein 0.0081 0.0275 0.1189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0926 0.3285
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.035 0.2505
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0177 0.0667 0.2887
Loa Loa (eye worm) major facilitator superfamily transporter 0.0081 0.0275 0.1189
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0055 0.0167 0.2092
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0016 0.0007 0.0019
Echinococcus multilocularis dna repair and recombination protein rad54 0.0017 0.0012 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.0492 0.1952 0.6934
Trypanosoma cruzi target of rapamycin kinase 3 0.0055 0.0167 0.2092
Brugia malayi Major Facilitator Superfamily protein 0.0081 0.0275 0.1189
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.1106 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Brugia malayi hypothetical protein 0.0492 0.1952 0.8445
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0178 0.0668 0.0997
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0145 0.0622
Plasmodium vivax glycine--tRNA ligase, putative 0.0033 0.0075 0.0068
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0049 0.0308
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0033 0.0075 0.2114
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Trichomonas vaginalis chaperonin, putative 0.0028 0.0056 0.0237
Schistosoma mansoni fkbp-rapamycin associated protein 0.0019 0.0019 0.0076
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0019 0.0021 0.007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0028 0.0274
Trypanosoma brucei glucose transporter, putative 0.018 0.0677 0.8771
Entamoeba histolytica hypothetical protein 0.0075 0.0249 0.1766
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0028 0.0056 0.0195
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0029 0.0033
Plasmodium vivax pyruvate kinase, putative 0.0039 0.01 0.0093
Brugia malayi replication factor A 73 kDa subunit 0.0016 0.0007 0.003
Toxoplasma gondii sugar transporter ST1 0.0081 0.0275 0.0404
Trypanosoma brucei pyruvate kinase 1 0.0039 0.01 0.1216
Brugia malayi Sugar transporter family protein 0.0081 0.0275 0.1189
Leishmania major T-complex protein 1, beta subunit, putative 0.0028 0.0056 0.0648
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Echinococcus multilocularis tumor protein p63 0.0702 0.2814 1
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0056 0.0237
Giardia lamblia DNA repair protein RAD52 0.0351 0.1376 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0049 0.0553
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.001 0.0035
Mycobacterium ulcerans integral membrane transport protein 0.0081 0.0275 0.5183
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0059 0.0251
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0049 0.0553
Echinococcus multilocularis lamin 0.0059 0.0182 0.0642
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0085 0.0291 0.0284
Onchocerca volvulus 0.0081 0.0275 0.6313
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0047 0.0204
Echinococcus granulosus lysyl tRNA synthetase 0.0129 0.0471 0.1668
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0019 0.0019 0.009
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0174 0.0653 0.2819
Loa Loa (eye worm) hypothetical protein 0.03 0.1167 0.5049
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0178 0.0668 0.0997
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Giardia lamblia Asparaginyl-tRNA synthetase 0.0019 0.0021 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Trypanosoma brucei sugar transporter, putative 0.0081 0.0275 0.351
Leishmania major hypothetical protein, conserved 0.0029 0.0059 0.0689
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0076 0.0265
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0021 0.0086
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0174 0.0653 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Onchocerca volvulus 0.0059 0.0182 0.4128
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.01 0.2188
Entamoeba histolytica protein kinase, putative 0.0177 0.0667 0.4824
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0189
Leishmania major lysyl-tRNA synthetase, putative 0.0129 0.0471 0.6074
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0362 0.1561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0926 0.4
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.01 0.0425
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0182 0.0788
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0476
Brugia malayi Protein kinase domain containing protein 0.0021 0.0029 0.0124
Schistosoma mansoni cpg binding protein 0.0034 0.008 0.0339
Schistosoma mansoni flap endonuclease-1 0.0024 0.0039 0.0161
Loa Loa (eye worm) hypothetical protein 0.0174 0.0653 0.2823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0019 0.0076
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0019 0.0021 0.0002
Entamoeba histolytica hypothetical protein 0.01 0.035 0.2505
Brugia malayi jmjC domain containing protein 0.0108 0.0382 0.1654
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Echinococcus multilocularis pyruvate kinase 0.0039 0.01 0.0349
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0907 0.3925
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.01 0.1216
Brugia malayi glycyl-tRNA synthetase 0.0033 0.0075 0.0324
Chlamydia trachomatis proline--tRNA ligase 0.0061 0.0193 0.3815
Toxoplasma gondii target of rapamycin (TOR), putative 0.0053 0.0157 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0926 0.3285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Loa Loa (eye worm) hypothetical protein 0.03 0.1167 0.5049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0118 0.0503
Echinococcus granulosus tumor protein p63 0.0702 0.2814 1
Echinococcus multilocularis pyruvate kinase 0.002 0.0023 0.0075
Plasmodium falciparum protein kinase 7 0.1637 0.6637 0.6635
Echinococcus granulosus muscleblind protein 0.03 0.1167 0.4144
Trichomonas vaginalis sugar transport protein, putative 0.0081 0.0275 0.1183
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0021 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.0431 0.1861
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.001 0.0042
Leishmania major lysyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Schistosoma mansoni glucose transporter 0.0081 0.0275 0.1183
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0129 0.0471 0.6074
Loa Loa (eye worm) MH2 domain-containing protein 0.0378 0.149 0.6445
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.002 0.0022 0.0109
Onchocerca volvulus 0.0081 0.0275 0.6313
Leishmania major hypothetical protein, conserved 0.0021 0.0029 0.0286
Trypanosoma cruzi sugar transporter, putative 0.0081 0.0275 0.351
Echinococcus multilocularis dna repair and recombination protein rad54 0.0017 0.0012 0.0038
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0049 0.0212
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0177 0.0667 0.2887
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0021 0.007
Leishmania major DNA repair and recombination protein RAD54, putative 0.0017 0.0012 0.0073
Brugia malayi hypothetical protein 0.0081 0.0275 0.1189
Echinococcus multilocularis pyruvate kinase 0.0039 0.01 0.0349
Entamoeba histolytica hypothetical protein 0.0034 0.0079 0.0526
Leishmania major histidyl-tRNA synthetase, putative 0.002 0.0022 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0677 0.2922
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0104 0.0445
Brugia malayi latrophilin 2 splice variant baaae 0.0281 0.109 0.4717
Schistosoma mansoni smad1 5 8 and 0.0026 0.0047 0.0197
Brugia malayi MH2 domain containing protein 0.0026 0.0047 0.0204
Toxoplasma gondii glycyl-tRNA synthetase 0.0033 0.0075 0.0103
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0064 0.0205 0.2598
Trichomonas vaginalis myo-inositol transporter, putative 0.0081 0.0275 0.1183
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0021 0.007
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0203 0.077 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0021 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0104 0.0445
Schistosoma mansoni hypothetical protein 0.0579 0.2312 1
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0033 0.0075 0.0892
Loa Loa (eye worm) RecQ helicase 0.0024 0.0041 0.0176
Loa Loa (eye worm) hypothetical protein 0.0141 0.0519 0.2247
Schistosoma mansoni pyruvate kinase 0.0039 0.01 0.0425
Onchocerca volvulus 0.012 0.0431 1
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.01 0.0425
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0023 0.0024
Onchocerca volvulus 0.0081 0.0275 0.6313
Trypanosoma brucei THT1 - hexose transporter, putative 0.018 0.0677 0.8771
Plasmodium vivax lysine--tRNA ligase, putative 0.0129 0.0471 0.0464
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0054
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.01 0.1216
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0076 0.0105
Echinococcus multilocularis peregrin 0.0035 0.0084 0.0291
Echinococcus multilocularis transient receptor potential ion channel A 0.0107 0.0379 0.1343
Echinococcus granulosus GPCR family 2 0.013 0.0473 0.1677
Trypanosoma cruzi hexose transporter, putative 0.0081 0.0275 0.351
Brugia malayi major facilitator superfamily protein 0.0081 0.0275 0.1189
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0174 0.0653 0.4717
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0081 0.0275 0.1183
Schistosoma mansoni hypothetical protein 0.0281 0.109 0.4713
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0021 0.0028 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0367 0.036
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0023 0.0213
Plasmodium vivax sugar transporter, putative 0.0081 0.0275 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0059 0.0689
Echinococcus granulosus lamin dm0 0.0059 0.0182 0.0642
Trypanosoma cruzi glucose transporter, putative 0.0081 0.0275 0.351
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.007 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0019 0.0021 0.007
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0079 0.0946
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0076 0.0323
Schistosoma mansoni replication factor A 1 rfa1 0.0016 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0231
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0016 0.0007 0.003
Toxoplasma gondii anticodon binding domain-containing protein 0.002 0.0022 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0017 0.0012 0.0047
Onchocerca volvulus 0.0081 0.0275 0.6313
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0021 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Trypanosoma brucei THT1 - hexose transporter, putative 0.018 0.0677 0.8771
Plasmodium vivax aspartate--tRNA ligase, putative 0.0019 0.0021 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.0473 0.2048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0097 0.0412
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0205 0.0888
Leishmania major pyruvate kinase 0.0039 0.01 0.1216
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0028 0.0056 0.0237
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Plasmodium falciparum T-complex protein 1 subunit beta 0.0028 0.0056 0.005
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0033
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0579 0.2312 0.8213
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.001 0.0003
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0203 0.077 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0367 0.036
Brugia malayi major facilitator superfamily protein 0.0081 0.0275 0.1189
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0511 1
Schistosoma mansoni hypothetical protein 0.013 0.0473 0.2042
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0081 0.0275 0.0268
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0021 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0128 0.0546
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0017 0.0012 0.0039
Schistosoma mansoni histidyl-tRNA synthetase 0.002 0.0022 0.0087
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Echinococcus granulosus solute carrier family 22 0.0081 0.0275 0.0972
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0041 0.0169
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.1106 0.8031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.0473 0.1677
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0104 0.0366
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0081 0.0275 0.532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0227
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.008 0.0346
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0435
Leishmania major pyruvate kinase 0.0039 0.01 0.1216
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0021 0.0189
Onchocerca volvulus Putative transporter 0.0081 0.0275 0.6313
Schistosoma mansoni smad1 5 8 and 0.0026 0.0047 0.0197
Schistosoma mansoni aspartyl-tRNA synthetase 0.0016 0.0007 0.0023
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0008 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1106 0.4783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0157 0.0671
Schistosoma mansoni hypothetical protein 0.01 0.0352 0.1516
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.0473 0.1677
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0049 0.0206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0411 0.1622 0.7017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0076 0.033
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0019 0.0021 0.019
Onchocerca volvulus 0.0021 0.0029 0.0514
Schistosoma mansoni threonyl-tRNA synthetase 0.002 0.0022 0.0087
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0178 0.0668 0.0661
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0177 0.0667 0.2887
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.01 0.1438
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0017 0.0012 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0129 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0926 0.3285
Plasmodium falciparum calcium-dependent protein kinase 5 0.0178 0.0668 0.0661
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0019 0.0021 0.007
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0343 0.4407
Schistosoma mansoni hypothetical protein 0.036 0.1414 0.6117
Toxoplasma gondii lysine-tRNA ligase 0.0129 0.0471 0.0699
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0275 0.1183
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1189

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.6 uM In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex ChEMBL. 10498204
Ki (binding) > 2.9 uM In vitro evaluation of inhibitory activity against trypsin ChEMBL. 10498204
Ki (binding) > 4 uM In vitro evaluation of inhibitory activity against Coagulation factor II in prothrombinase complex ChEMBL. 10498204
pKa = 5.3 pKa value of the compound was determined. ChEMBL. 10498204

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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