Detailed information for compound 140091

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.334 | Formula: C21H15Cl2N3OS
  • H donors: 0 H acceptors: 2 LogP: 6.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)c1nn(c(n1)S)Cc1cccc(c1)Oc1ccccc1
  • InChi: 1S/C21H15Cl2N3OS/c22-15-9-10-18(19(23)12-15)20-24-21(28)26(25-20)13-14-5-4-8-17(11-14)27-16-6-2-1-3-7-16/h1-12H,13H2,(H,24,25,28)
  • InChiKey: VGWBEDMOOQUIKD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-X-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protocadherin 11 0.0009 0.0018 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.0041
Giardia lamblia Kinase, CAMK CAMKL 0.001 0.0037 0.0418
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0061 0.0027
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0496 0.0516
Brugia malayi CXXC zinc finger family protein 0.0029 0.0413 0.0659
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0442 0.0432
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0135 0.0205
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) hypothetical protein 0.0032 0.0476 0.0467
Schistosoma mansoni lipoxygenase 0.0088 0.1613 0.1996
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0476 0.1995
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0497 0.1004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.1038 0.1467
Schistosoma mansoni autophagin-1 (C54 family) 0.0068 0.1206 0.1492
Toxoplasma gondii sugar transporter ST2 0.0015 0.0135 0.0143
Brugia malayi nuclear hormone receptor 0.001 0.0038 0.0046
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.3159 0.4576
Schistosoma mansoni hypothetical protein 0.0099 0.1826 0.2259
Entamoeba histolytica peptidase, C54 family 0.0026 0.0369 0.1624
Brugia malayi MH2 domain containing protein 0.0127 0.241 0.3923
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0582 0.0799
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1757 0.1749
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0496 0.0411
Brugia malayi cyclin-dependent kinase 7 homolog 0.001 0.0037 0.0045
Loa Loa (eye worm) sugar transporter 0.0015 0.0135 0.0125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0468 0.0379
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0496 0.0411
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.2179 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0259 0.0282
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0038 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0448 0.0555
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0468 0.0939
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0495 0.0794
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0468 0.0939
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0311 0.0338
Onchocerca volvulus 0.0015 0.0135 0.0117
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.3159 0.4576
Echinococcus granulosus FTZ F1 alpha 0.001 0.0038 0.0041
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0135 0.024
Giardia lamblia Hexose transporter 0.0015 0.0135 0.2551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0028
Trypanosoma brucei sugar transporter, putative 0.0015 0.0135 0.0143
Brugia malayi Cytochrome P450 family protein 0.0011 0.0051 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Schistosoma mansoni cpg binding protein 0.0029 0.0413 0.0511
Onchocerca volvulus Phospholipase A2 homolog 0.0106 0.1974 0.196
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0068 0.1206 0.2549
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1084 0.1342
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Leishmania major protein kinase, putative 0.0033 0.0495 0.0671
Onchocerca volvulus 0.0015 0.0135 0.0117
Echinococcus granulosus solute carrier family 22 0.0015 0.0135 0.0146
Schistosoma mansoni glucose transport protein 0.0106 0.1973 0.2442
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0496 0.0516
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0038 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.1826 0.1981
Echinococcus granulosus Peptidase C54 0.0068 0.1206 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0135 0.0213
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0135 0.0146
Entamoeba histolytica protein kinase domain containing protein 0.001 0.0037 0.0089
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.1973 0.2141
Echinococcus multilocularis solute carrier family 22 0.0015 0.0135 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.0041
Echinococcus multilocularis serine:threonine protein kinase NLK 0.001 0.0037 0.004
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0311 0.0494
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Onchocerca volvulus 0.0015 0.0135 0.0117
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0068 0.1206 0.1492
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1757 0.2855
Onchocerca volvulus Putative transporter 0.0015 0.0135 0.0117
Loa Loa (eye worm) hypothetical protein 0.0068 0.1206 0.1197
Schistosoma mansoni glucose transport protein 0.0106 0.1973 0.2442
Schistosoma mansoni hypothetical protein 0.0364 0.7192 0.89
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.2179 0.2365
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0311 0.1223
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0038 0.002
Brugia malayi steroid hormone receptor 0.001 0.0038 0.0046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0953 0.1546
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0135 0.024
Plasmodium vivax SET domain protein, putative 0.003 0.0448 0.0463
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0009 0.0018 0.002
Schistosoma mansoni hypothetical protein 0.0099 0.1826 0.2259
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0038 0.0041
Entamoeba histolytica protein kinase, putative 0.0033 0.0495 0.2208
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0068 0.1206 0.1713
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.6859 1
Onchocerca volvulus 0.0015 0.0135 0.0117
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0051 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0038 0.0041
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.024 0.0541
Brugia malayi phosphofructokinase 0.0116 0.2179 0.3546
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Onchocerca volvulus 0.0015 0.0135 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0476 0.0467
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0476 0.2118
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0135 0.024
Echinococcus granulosus geminin 0.0364 0.7192 0.7805
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0038 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0271 0.0428
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0038 0.0047
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0468 0.0714
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0582 0.0799
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0495 0.0486
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0468 0.9821
Echinococcus granulosus solute carrier family 22 0.0015 0.0135 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0046
Onchocerca volvulus 0.0021 0.0259 0.0242
Brugia malayi Pre-SET motif family protein 0.0208 0.4042 0.6591
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0271 0.0264
Echinococcus granulosus solute carrier family 22 0.0015 0.0135 0.0146
Entamoeba histolytica peptidase, C54 family 0.0026 0.0369 0.1624
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3297 0.5564
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0026 0.0369 0.0486
Brugia malayi 6-phosphofructokinase 0.0116 0.2179 0.3546
Echinococcus granulosus dnaJ subfamily B 0.0408 0.808 0.8769
Loa Loa (eye worm) hypothetical protein 0.0311 0.6128 0.6125
Schistosoma mansoni protein kinase 0.0033 0.0495 0.0613
Onchocerca volvulus 0.0015 0.0135 0.0117
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0311 0.0338
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0135 0.0143
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0051 0.0021
Schistosoma mansoni hypothetical protein 0.0099 0.1826 0.2259
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Schistosoma mansoni smad1 5 8 and 0.0009 0.001 0.0012
Leishmania major cytochrome p450-like protein 0.0011 0.0051 0.0021
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.2179 0.2697
Plasmodium vivax hexose transporter 0.0106 0.1973 0.218
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0448 0.0487
Trypanosoma brucei glucose transporter 2A 0.0033 0.0497 0.0675
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0271 0.0995
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0582 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus granulosus Cell division cycle 2 protein kinase 0.001 0.0037 0.004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Schistosoma mansoni rab6-interacting 0.0021 0.0259 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.1973 0.4222
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0051 0.0056
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.024 0.0541
Echinococcus multilocularis cpg binding protein 0.003 0.0446 0.0484
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.6128 1
Schistosoma mansoni hypothetical protein 0.0009 0.0018 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.6128 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1757 0.1906
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.1826 0.1818
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0038 0.0046
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.024 0.0885
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0038 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0271 0.0343
Brugia malayi hypothetical protein 0.0021 0.0259 0.0408
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0796 0.0985
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0449 0.0487
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.001 0.0037 0.004
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.1973 0.3295
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0476 0.0589
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0068 0.1206 0.2549
Loa Loa (eye worm) bZIP transcription factor family protein 0.0009 0.0018 0.0009
Toxoplasma gondii sugar transporter ST1 0.0015 0.0135 0.0143
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0026 0.0369 0.0486
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0929 0.1008
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0259 0.0142
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0496 0.0762
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0051 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0038 0.0028
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.6859 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0311 0.0402
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0582 0.0799
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0448 0.0681
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0271 0.0343
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2179 0.4672
Brugia malayi Cell death specification protein 2 0.0009 0.0018 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0497 0.1004
Loa Loa (eye worm) histone methyltransferase 0.001 0.0035 0.0026
Schistosoma mansoni hypothetical protein 0.0294 0.5768 0.7139
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0796 0.0863
Onchocerca volvulus Phospholipase A2 homolog 0.0503 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0135 0.0146
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0497 0.0675
Schistosoma mansoni hypothetical protein 0.0364 0.7192 0.89
Brugia malayi Pre-SET motif family protein 0.003 0.0448 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1757 0.1906
Schistosoma mansoni protein kinase 0.001 0.0037 0.0046
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0497 0.0675
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0271 0.0295
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0496 0.0516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0038 0.0047
Brugia malayi major facilitator superfamily protein 0.0015 0.0135 0.0205
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0468 0.208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0271 0.5537
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0068 0.1206 0.2549
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Onchocerca volvulus 0.0015 0.0135 0.0117
Leishmania major glucose transporter, lmgt1 0.0033 0.0497 0.0675
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0311 0.6163
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0497 0.1004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0028
Echinococcus granulosus RUN 0.0021 0.0259 0.0282
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0068 0.1206 0.1713
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0497 0.1004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0796 0.0787
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0155 0.2966 0.2959
Plasmodium vivax sugar transporter, putative 0.0015 0.0135 0.011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0796 0.0863
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.2179 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0018 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0038 0.0041
Onchocerca volvulus 0.0048 0.0796 0.0779
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0448 0.0555
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.0041
Schistosoma mansoni hypothetical protein 0.0106 0.1973 0.2442
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.001 0.0012
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0497 0.0675
Brugia malayi Phospholipase A2 family protein 0.0106 0.1974 0.3211
Onchocerca volvulus 0.0015 0.0135 0.0117
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0259 0.025
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0496 0.0762
Schistosoma mansoni par domain protein 0.0009 0.0018 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0468 0.0939
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0009
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0582 0.0799
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0796 0.0985
Schistosoma mansoni ap endonuclease 0.0022 0.0271 0.0336
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0112 0.2089 0.3494
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0271 0.0295
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.001 0.0037 0.0028
Toxoplasma gondii sugar transporter ST3 0.0015 0.0135 0.0143
Echinococcus multilocularis protocadherin 11 0.0009 0.0018 0.002
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0035 0.0038
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0068 0.1206 0.1713
Schistosoma mansoni sugar transporter 0.0015 0.0135 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0028
Echinococcus multilocularis protocadherin 11 0.0009 0.0018 0.002
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0197 0.0234
Brugia malayi Cell death specification protein 2 0.0009 0.0018 0.0014
Leishmania major hypothetical protein, conserved 0.0015 0.0135 0.0143
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2179 0.4672
Schistosoma mansoni ap endonuclease 0.0022 0.0271 0.0336
Echinococcus granulosus mitogen activated protein kinase 15 0.001 0.0037 0.004
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0051 0.0021
Onchocerca volvulus 0.001 0.0038 0.002
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0495 0.0671
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.025
Schistosoma mansoni rab6-interacting 0.0021 0.0259 0.0321
Brugia malayi Cytochrome P450 family protein 0.0011 0.0051 0.0068
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0259 0.0282
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Loa Loa (eye worm) hypothetical protein 0.003 0.0448 0.0439
Leishmania major cytochrome p450-like protein 0.0011 0.0051 0.0021
Echinococcus granulosus General substrate transporter 0.0091 0.1672 0.1815
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0497 0.0675
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0413 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0028
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0822 0.115
Schistosoma mansoni hypothetical protein 0.0408 0.808 1
Plasmodium falciparum hexose transporter 0.0106 0.1973 0.2093
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0448 0.0487
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.9215 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Brugia malayi Cell death specification protein 2 0.0009 0.0018 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.2179 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.0041
Mycobacterium ulcerans hypothetical protein 0.0183 0.3534 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1757 0.1906
Onchocerca volvulus 0.0015 0.0135 0.0117
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0033 0.0038
Schistosoma mansoni serine/threonine kinase 0.001 0.0037 0.0046
Echinococcus multilocularis RUN 0.0021 0.0259 0.0282
Schistosoma mansoni hypothetical protein 0.0213 0.4137 0.512
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0468 0.1921
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0259 0.0282
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0796 0.0863
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0929 0.1008
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.9215 1
Echinococcus granulosus muscleblind protein 0.0155 0.2966 0.3219
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0496 0.0411
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0051 0.0042
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0476 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0028
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.001 0.0037 0.0028
Entamoeba histolytica peptidase, C54 family 0.0068 0.1206 0.5496
Brugia malayi mbt repeat family protein 0.0048 0.0796 0.1285
Giardia lamblia Sugar-proton symporter 0.0015 0.0135 0.2551
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2179 0.4672
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0259 0.0282
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0449 0.0487
Brugia malayi hypothetical protein 0.0015 0.0135 0.0205
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0468 0.0714
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.2179 0.6109
Schistosoma mansoni smad1 5 8 and 0.0009 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0009 0.0018 0.0022
Entamoeba histolytica cell division protein kinase 2, putative 0.001 0.0037 0.0089
Onchocerca volvulus 0.0021 0.0259 0.0242
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0038 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0271 0.0343
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0009
Brugia malayi mbt repeat family protein 0.0048 0.0796 0.1285
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0135 0.0146
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.2379 0.2581
Trypanosoma brucei glucose transporter 1E 0.0033 0.0497 0.0675
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0018 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0135 0.0213
Schistosoma mansoni smad1 5 8 and 0.0009 0.001 0.0012
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0468 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0468 1
Schistosoma mansoni glucose transporter 0.0015 0.0135 0.0167
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0796 0.0863
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0009 0.0018 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.0041
Brugia malayi cytochrome P450 0.0011 0.0051 0.0068
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0476 0.0516
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.241 0.2403
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0135 0.0143
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.2179 0.6109
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0822 0.115
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0796 0.0779
Loa Loa (eye worm) hypothetical protein 0.0024 0.0311 0.0302
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0468 0.0714
Brugia malayi hypothetical protein 0.0009 0.0018 0.0014
Schistosoma mansoni loxhd1 0.0021 0.0259 0.0321
Plasmodium falciparum protein kinase 7 0.0299 0.5884 0.6545
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.241 0.2403
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3297 0.367
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0495 0.0613
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0311 0.0747
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0476 1
Brugia malayi Cam kinase protein 1 0.0033 0.0495 0.0794
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.1826 0.1981
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.2179 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0135 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1757 0.2174
Entamoeba histolytica peptidase, C54 family 0.0026 0.0369 0.1624
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0135 0.0143
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0311 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1757 0.2174
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.4042 0.4037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.0041
Entamoeba histolytica hypothetical protein 0.0024 0.0311 0.1358
Toxoplasma gondii hypothetical protein 0.0056 0.0967 0.157
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0476 0.0762
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.2179 0.2365
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0796 0.0985
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0476 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0497 0.1004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0038 0.0047
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) cytochrome P450 0.0011 0.0051 0.0042
Trypanosoma cruzi hexose transporter 0.0033 0.0497 0.0675
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0468 0.0939
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0135 0.0213
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0135 0.0143
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0497 0.1004
Schistosoma mansoni sugar transporter 0.0015 0.0135 0.0167
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.2179 0.314
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.6859 1
Giardia lamblia Kinase, CAMK CAMKL 0.001 0.0037 0.0418
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0822 0.115
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0414 0.0449
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0135 0.0213
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0582 0.0799
Schistosoma mansoni hypothetical protein 0.0011 0.0051 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0448 0.0555
Schistosoma mansoni hypothetical protein 0.0099 0.1826 0.2259
Echinococcus multilocularis solute carrier family 22 0.0015 0.0135 0.0146
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.001 0.001
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0051 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0259 0.025
Echinococcus granulosus cyclin dependent kinase 9 0.001 0.0037 0.004
Plasmodium falciparum cysteine protease ATG4, putative 0.0026 0.0369 0.0267
Onchocerca volvulus 0.0015 0.0135 0.0117
Schistosoma mansoni nuclear hormone receptor 0.001 0.0038 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0035 0.0038
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0026 0.0369 0.0486
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0495 0.0486
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0476 0.0957
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.2179 0.2697
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0038 0.0046
Mycobacterium ulcerans sugar transporter 0.0015 0.0135 0.024
Echinococcus multilocularis solute carrier family 22 0.0015 0.0135 0.0146
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0051 0.0042
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.2179 0.314
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) MBCTL1 0.0054 0.0929 0.092
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0496 0.0516
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0135 0.0213
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0135 0.0205
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0038 0.0041
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0068 0.1206 0.1492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Leishmania major glucose transporter, lmgt2 0.0033 0.0497 0.0675
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.2179 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0929 0.1149
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.001 0.001
Brugia malayi hypothetical protein 0.0009 0.0018 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0099 0.1826 0.2968
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0135 0.0205
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.2179 0.2172
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0311 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Brugia malayi nuclear receptor NHR-88 0.001 0.0038 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0009 0.0018 0.002
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0068 0.1206 0.2549
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0468 0.0939
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0271 0.0511
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0497 0.1004
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0476 0.0762
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.3712 0.4028
Schistosoma mansoni protein kinase 0.0033 0.0495 0.0613
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0311 0.0747
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.2379 0.2581
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0135 0.0146
Loa Loa (eye worm) hypothetical protein 0.0155 0.2966 0.2959
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.808 0.8769
Echinococcus granulosus neuropeptide s receptor 0.0464 0.9215 1
Echinococcus multilocularis muscleblind protein 0.0155 0.2966 0.3219
Brugia malayi hypothetical protein 0.0021 0.0259 0.0408
Schistosoma mansoni glucose transport protein 0.0106 0.1973 0.2442
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.001 0.001
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0046
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0009 0.0018 0.002
Brugia malayi 6-phosphofructokinase 0.0116 0.2179 0.3546
Loa Loa (eye worm) hypothetical protein 0.0213 0.4137 0.4131
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.1826 0.1981
Brugia malayi Sugar transporter family protein 0.0015 0.0135 0.0205
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Onchocerca volvulus 0.0015 0.0135 0.0117
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0026 0.0369 0.0486
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.4137 0.6745
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0271 0.0632
Onchocerca volvulus 0.0015 0.0135 0.0117
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0068 0.1206 0.2549
Loa Loa (eye worm) phosphofructokinase 0.0116 0.2179 0.2172
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0311 0.0402
Toxoplasma gondii protein kinase, putative 0.0299 0.5884 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0271 0.0343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.0041
Loa Loa (eye worm) sugar transporter 0.0106 0.1973 0.1965
Loa Loa (eye worm) hypothetical protein 0.0026 0.0355 0.0346
Schistosoma mansoni cpg binding protein 0.003 0.0446 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0038 0.0041
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0311 0.0402
Brugia malayi Muscleblind-like protein 0.0155 0.2966 0.4832
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0929 0.1502
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.1826 0.2968
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0311 0.6411
Onchocerca volvulus 0.0015 0.0135 0.0117
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0496 0.0762
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0468 0.0379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0009
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0582 0.0614
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Loa Loa (eye worm) haspin protein kinase 0.001 0.0037 0.0028
Echinococcus granulosus Smad4 0.0009 0.001 0.001
Brugia malayi hypothetical protein 0.0009 0.0018 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0271 0.0632
Echinococcus granulosus smad 0.0009 0.001 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0271 0.0156
Plasmodium vivax CDK-related protein kinase 6, putative 0.045 0.8919 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.3159 0.4576
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Brugia malayi Cytochrome P450 family protein 0.0011 0.0051 0.0068
Plasmodium falciparum protein kinase 6 0.045 0.8919 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0495 0.0537
Brugia malayi major facilitator superfamily protein 0.0015 0.0135 0.0205
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0259 0.0282
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0496 0.0411
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Loa Loa (eye worm) hypothetical protein 0.0054 0.0929 0.092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0271 1
Schistosoma mansoni hypothetical protein 0.0021 0.0259 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0051 0.0021
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0311 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0259 0.0282
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Brugia malayi Cell division protein kinase 2 0.001 0.0037 0.0045
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0119 0.2245 0.2486
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.2179 0.4672
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Onchocerca volvulus 0.0029 0.0413 0.0396
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0026 0.0369 0.0545
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0822 0.115
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Schistosoma mansoni lipoxygenase 0.0126 0.2379 0.2944
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0135 0.0167
Echinococcus multilocularis Smad4 0.0009 0.001 0.001
Schistosoma mansoni protein kinase 0.0033 0.0495 0.0613
Trichomonas vaginalis set domain proteins, putative 0.0237 0.4622 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0495 0.2208
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0497 0.0675
Brugia malayi Hepatic leukemia factor 0.0009 0.0018 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.1826 0.1981
Brugia malayi Sugar transporter family protein 0.0015 0.0135 0.0205
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0135 0.0143
Echinococcus granulosus protocadherin 11 0.0009 0.0018 0.002
Onchocerca volvulus 0.0015 0.0135 0.0117
Brugia malayi ecdysteroid receptor 0.001 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0468 0.0939
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Echinococcus multilocularis geminin 0.0364 0.7192 0.7805
Brugia malayi Doublecortin family protein 0.0021 0.0259 0.0408
Echinococcus multilocularis smad 0.0009 0.001 0.001
Schistosoma mansoni sugar transporter 0.0015 0.0135 0.0167
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0271 0.0262
Schistosoma mansoni polycystin 1-related 0.0021 0.0259 0.0321
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0038 0.0047
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0496 0.0411
Echinococcus multilocularis GPCR, family 2 0.0099 0.1826 0.1981
Toxoplasma gondii exonuclease III APE 0.0022 0.0271 0.0378
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.001 0.001
Brugia malayi Cytochrome P450 family protein 0.003 0.0442 0.0706
Leishmania major cytochrome p450-like protein 0.0011 0.0051 0.0021
Plasmodium falciparum MO15-related protein kinase 0.0119 0.2245 0.2403
Echinococcus multilocularis muscleblind protein 1 0.0155 0.2966 0.3219
Echinococcus granulosus cpg binding protein 0.003 0.0446 0.0484
Schistosoma mansoni Smad4 0.0009 0.001 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0038 0.0041
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0497 0.0675
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0051 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1757 0.2174
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0135 0.0125
Onchocerca volvulus 0.0015 0.0135 0.0117
Schistosoma mansoni smad 0.0009 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0106 0.1974 0.1967
Echinococcus granulosus GPCR family 2 0.0099 0.1826 0.1981
Schistosoma mansoni cpg binding protein 0.003 0.0446 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0135 0.0213
Brugia malayi bZIP transcription factor family protein 0.0009 0.0018 0.0014
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0135 0.0213
Brugia malayi Protein kinase domain containing protein 0.001 0.0037 0.0045
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Loa Loa (eye worm) hypothetical protein 0.0099 0.1826 0.1818
Schistosoma mansoni coup transcription factor 0.001 0.0038 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0038 0.0028
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0009 0.0018 0.0022
Echinococcus multilocularis Peptidase C54 0.0068 0.1206 0.1309
Schistosoma mansoni hypothetical protein 0.0287 0.5642 0.6983
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0497 0.0675
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Echinococcus multilocularis X box binding protein 1 0.0287 0.5642 0.6123
Echinococcus granulosus serine:threonine protein kinase NLK 0.001 0.0037 0.004
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0448 0.0487
Trypanosoma brucei glucose transporter, putative 0.0033 0.0497 0.0675
Onchocerca volvulus 0.0015 0.0135 0.0117
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.2179 0.2172
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.9215 1
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0009 0.0018 0.002
Schistosoma mansoni sugar transporter 0.0015 0.0135 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.3534 1
Echinococcus multilocularis 0.0011 0.0051 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0495 0.0999
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0125
Leishmania major glucose transporter, lmgt3 0.0033 0.0497 0.0675
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0796 0.0787
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0468 0.0485
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0135 0.024
Schistosoma mansoni thyrotroph embryonic factor related 0.0009 0.0018 0.0022
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0038 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0038 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0009 0.0018 0.002
Entamoeba histolytica peptidase, C54 family 0.0026 0.0369 0.1624
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0051 0.0021
Loa Loa (eye worm) cell death specification protein 2 0.0009 0.0018 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0271 0.0511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.6128 0.6125
Echinococcus granulosus cysteine protease atg4b 0.0068 0.1206 0.1309
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0259 0.025
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0038 0.0047
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0929 0.1008
Echinococcus granulosus solute carrier family 22 0.0015 0.0135 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1757 0.1906
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0135 0.0125
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0046
Echinococcus multilocularis cyclin dependent kinase 9 0.001 0.0037 0.004
Echinococcus granulosus X box binding protein 1 0.0287 0.5642 0.6123
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0135 0.0143
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0311 0.0598
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0929 0.1008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0046
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0582 0.091
Echinococcus granulosus ccaat enhancer binding protein delta 0.0009 0.0018 0.002
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.2179 0.314
Onchocerca volvulus 0.0237 0.4622 0.4612
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0468 0.0485
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0135 0.0213
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.3712 0.4028
Brugia malayi Peptidase family C54 containing protein 0.0068 0.1206 0.1955
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0448 0.0555
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0097 0.0088
Echinococcus multilocularis General substrate transporter 0.0091 0.1672 0.1815
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0253 0.047
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0311 0.0386
Giardia lamblia Kinase, CAMK CAMKL 0.001 0.0037 0.0418
Echinococcus multilocularis solute carrier family 22 0.0015 0.0135 0.0146
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1973 0.2141
Onchocerca volvulus 0.003 0.0448 0.0431
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0051 0.0021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0495 0.0537
Schistosoma mansoni cytochrome P450 0.0011 0.0051 0.0063
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0271 0.1173
Brugia malayi Sugar transporter family protein 0.0106 0.1973 0.3209
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3297 0.36
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0311 0.0446
Brugia malayi hypothetical protein 0.0015 0.0135 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0028
Brugia malayi hypothetical protein 0.0015 0.0135 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0495 0.0486
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0038 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0468 0.0939
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.6859 1
Echinococcus multilocularis cysteine protease atg4b 0.0068 0.1206 0.1309

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.17 uM Inhibition of binding of [125I]-IL8 to human recombinant CXC chemokine receptor 2 (CXCR2) expressed in HEK 293 membranes ChEMBL. 12873480
IC50 (binding) = 0.17 uM Inhibition of binding of [125I]-IL8 to human recombinant CXC chemokine receptor 2 (CXCR2) expressed in HEK 293 membranes ChEMBL. 12873480

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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