Detailed information for compound 1402909

Basic information

Technical information
  • TDR Targets ID: 1402909
  • Name: methyl 4-(6-methyl-1,3-benzoxazol-2-yl)benzoa te
  • MW: 267.279 | Formula: C16H13NO3
  • H donors: 0 H acceptors: 2 LogP: 3.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)c1nc2c(o1)cc(cc2)C
  • InChi: 1S/C16H13NO3/c1-10-3-8-13-14(9-10)20-15(17-13)11-4-6-12(7-5-11)16(18)19-2/h3-9H,1-2H3
  • InChiKey: QHFPLQJQGDKMSF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-(6-methyl-1,3-benzoxazol-2-yl)benzoic acid methyl ester
  • BAS 00140157
  • 4-(6-Methyl-benzooxazol-2-yl)-benzoic acid methyl ester
  • MLS000029722
  • SMR000001135
  • ZINC00235537
  • EU-0033669
  • Oprea1_316275
  • Oprea1_270740

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0072 0.0577 0.5513
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0082 0.0941
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0299 0.0292
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0593 0.7382
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0153 0.1411
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.057 0.2106
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.08 1
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0433 0.537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0373 0.0366
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0553 0.0546
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.3545 0.3541
Brugia malayi glutathione reductase 0.0057 0.0433 0.1593
Schistosoma mansoni jumonji domain containing protein 0.0071 0.057 0.0698
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0189
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1296 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0553 0.4235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0153 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0031 0.0179 0.0172
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0014 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0153 0.1132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0546
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8068 0.8067
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0058 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0179 0.3017
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.057 0.0563
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.3545 0.3541
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0153 0.1132
Echinococcus multilocularis protein dispatched 1 0.0058 0.0444 0.0437
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0191 0.2323
Toxoplasma gondii thioredoxin reductase 0.0057 0.0433 0.537
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1041 0.1034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0173
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0153 0.1185
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0058 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0593 0.7172
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.048 0.3672
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.048 0.0473
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0153 0.0412
Schistosoma mansoni netrin receptor unc5 0.0038 0.0247 0.0298
Loa Loa (eye worm) hypothetical protein 0.0094 0.08 0.2967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0153 0.0546
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0433 0.3306
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1296 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0593 0.0586
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1041 1
Brugia malayi Probable ClpP-like protease 0.0094 0.08 0.2967
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0058 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0058 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.057 0.0698
Echinococcus granulosus geminin 0.0205 0.1884 0.1878
Brugia malayi jmjC domain containing protein 0.0071 0.057 0.2106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0247 0.024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.9504 0.9503
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0066 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0153 0.1185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0546
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.048 0.3672
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0058 0.0051
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1543 0.1537
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0058 0.0051
Toxoplasma gondii FATC domain-containing protein 0.004 0.0269 0.3306
Schistosoma mansoni hypothetical protein 0.0043 0.0299 0.0362
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0473
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0066 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0153 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0247 0.0898
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0553 0.663
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1296 1
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0072 0.0577 0.1673
Entamoeba histolytica protein kinase rad3, putative 0.004 0.0269 0.2537
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0058 0.0637
Loa Loa (eye worm) hypothetical protein 0.0119 0.1041 0.3867
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1059 0.1305
Echinococcus multilocularis serine protein kinase ATM 0.004 0.0269 0.0262
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0299 0.0362
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0058 0.0637
Brugia malayi Uncoordinated protein 44 0.0038 0.0247 0.0898
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0058 0.0051
Onchocerca volvulus 0.0014 0.0007 0.0043
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.268 0.2675
Entamoeba histolytica hypothetical protein 0.0043 0.0299 0.2821
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0577 0.1609
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0082 0.0215
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0066 0.1033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0072 0.0577 0.2132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Echinococcus multilocularis protein patched 0.0051 0.0373 0.0366
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0072 0.0577 0.1673
Loa Loa (eye worm) hypothetical protein 0.0045 0.0315 0.1151
Echinococcus granulosus Ankyrin 0.0038 0.0249 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.268 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0153 0.1185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.007 0.049
Onchocerca volvulus 0.0029 0.0153 0.0919
Echinococcus granulosus serine:threonine protein kinase SMG1 0.004 0.0269 0.0262
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0072 0.0577 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0247 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0058 0.0051
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0507 0.187
Onchocerca volvulus 0.0058 0.0444 0.2667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0173
Entamoeba histolytica hypothetical protein 0.0043 0.0299 0.2821
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0433 0.125
Mycobacterium tuberculosis Probable reductase 0.013 0.1153 0.889
Loa Loa (eye worm) hypothetical protein 0.0029 0.0153 0.0546
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0981
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1153 0.889
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1153 0.889
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0432
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0066 0.0742
Brugia malayi Protein kinase domain containing protein 0.0038 0.0247 0.0898
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0134 0.2219
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0058 0.0051
Trypanosoma brucei trypanothione reductase 0.0057 0.0433 0.7474
Brugia malayi FAT domain containing protein 0.0031 0.0179 0.0643
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0173
Leishmania major trypanothione reductase 0.0057 0.0433 0.1202
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0153 0.1411
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0072 0.0577 0.2132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0247 0.0898
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0058 0.0148
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0072 0.0577 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0373 0.137
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0066 0.1033
Schistosoma mansoni fkbp-rapamycin associated protein 0.004 0.0269 0.0325
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.08 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0315 0.5399
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1296 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0066 0.022
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0045 0.0315 0.5399
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0066 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0066 0.1033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0593 0.0586
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1153 0.889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0553 0.2041
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0066 0.0742
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0058 0.0051
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0072 0.0577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0179 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.004 0.0269 0.077
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0058 0.0189
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1543 0.1537
Schistosoma mansoni survival motor neuron protein 0.0058 0.0444 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.004 0.0269 0.2537
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0058 0.0063
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0072 0.0577 0.057
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0066 0.1033
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1153 0.889
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0577 0.2132
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.08 0.0794
Loa Loa (eye worm) glutathione reductase 0.0057 0.0433 0.1593
Brugia malayi Thioredoxin reductase 0.0057 0.0433 0.1593
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.007 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0593 0.0726
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0553 0.154
Leishmania major hypothetical protein, conserved 0.0374 0.355 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0553 0.0546
Brugia malayi hypothetical protein 0.0043 0.0299 0.1091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0247 0.0898
Brugia malayi jmjC domain containing protein 0.0019 0.0058 0.0189
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.048 0.0473
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0444 0.1635
Loa Loa (eye worm) hypothetical protein 0.0182 0.1666 0.6207
Brugia malayi jmjC domain containing protein 0.0071 0.057 0.2106
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0066 0.0166
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0058 0.0637
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0066 0.1033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0279
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0082 0.058
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0072 0.0577 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Schistosoma mansoni hypothetical protein 0.0031 0.0179 0.0213
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.004 0.0269 0.0325
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0279
Echinococcus multilocularis expressed conserved protein 0.0112 0.097 0.0963
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0593 0.0726
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0066 0.0059
Echinococcus multilocularis Ankyrin 0.0038 0.0249 0.0242
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0134 0.0371
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0058 0.0887
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0279
Loa Loa (eye worm) hypothetical protein 0.0051 0.0373 0.137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0247 0.0298
Giardia lamblia GTOR 0.0072 0.0577 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8068 0.8067
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0066 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0045 0.0315 0.3879
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0593 0.7172
Echinococcus granulosus death domain containing protein 0.0038 0.0247 0.024
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.08 0.0984
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0153 0.0412
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0072 0.0577 0.5513
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.004 0.0269 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0433 0.0426
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0031 0.0179 0.0172
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0191 0.143
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0153 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0153 0.1411
Brugia malayi jmjC domain containing protein 0.0019 0.0058 0.0189
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0066 0.0742
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0072 0.0577 0.1673
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0433 0.1593
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0577 0.1673
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1041 0.3867
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0072 0.0577 0.1673
Echinococcus granulosus phd:f box containing protein 0.0019 0.0058 0.0051
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0066 0.0173
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0247 0.024
Echinococcus granulosus expressed conserved protein 0.0112 0.097 0.0963
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0373 0.0366
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.057 0.0563
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0072 0.0577 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0072 0.0577 0.057
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0247 0.024
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.08 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0072 0.0577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1153 0.889
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0269 0.0981
Toxoplasma gondii hypothetical protein 0.0033 0.0191 0.2323
Echinococcus multilocularis geminin 0.0205 0.1884 0.1878
Plasmodium vivax JmjC domain containing protein 0.0019 0.0058 0.0637
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0432
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0153 0.1185
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0249 0.0299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0269 0.0981
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.057 0.0698
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0153 0.0546
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0072 0.0577 0.1609
Entamoeba histolytica hypothetical protein 0.0043 0.0299 0.2821
Brugia malayi Death domain containing protein 0.0038 0.0247 0.0898
Brugia malayi hypothetical protein 0.0182 0.1666 0.6207
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0153 0.1185
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0153 0.0412
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0058 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1153 0.889
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.004 0.0269 0.0262
Brugia malayi jmjC domain containing protein 0.0019 0.0058 0.0189
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0433 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0577 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0058 0.0189
Brugia malayi CHE-14 protein 0.0051 0.0373 0.137
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0153 0.1132
Schistosoma mansoni hypothetical protein 0.0205 0.1884 0.2328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0279
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0066 0.1033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0189
Onchocerca volvulus 0.0014 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0269 0.4601
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.268 0.2675
Plasmodium falciparum glutathione reductase 0.002 0.0066 0.0742
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0066 0.0742
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0247 0.1483
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0191 0.2323
Onchocerca volvulus 0.0182 0.1666 1
Brugia malayi jmjC domain containing protein 0.0019 0.0058 0.0189
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0072 0.0577 0.057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0189
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0373 0.0366
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0072 0.0577 0.0707
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0066 0.1033
Loa Loa (eye worm) phosphatidylinositol 3 0.0072 0.0577 0.2132
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.08 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.057 0.0563
Schistosoma mansoni hypothetical protein 0.0205 0.1884 0.2328
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0553 0.663
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0373 0.6424
Plasmodium falciparum thioredoxin reductase 0.002 0.0066 0.0742
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.08 0.6156
Plasmodium vivax glutathione reductase, putative 0.0057 0.0433 0.537
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1041 0.1034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.007 0.049
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0066 0.0742
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0058 0.0148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0173
Plasmodium falciparum glutathione reductase 0.0057 0.0433 0.537
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.007 0.049
Schistosoma mansoni hypothetical protein 0.0038 0.0247 0.0298
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0058 0.0189
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0072 0.0577 0.1609
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0553 0.0677
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0593 0.4544
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0066 0.0742
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0191 0.1708
Brugia malayi hypothetical protein 0.0286 0.268 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.057 0.0563
Schistosoma mansoni hypothetical protein 0.0058 0.0444 0.0542
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0153 0.1185
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8068 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0082 0.0215
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.08 1
Schistosoma mansoni patched 1 0.0051 0.0373 0.0454
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0153 0.0546
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0593 0.7172
Loa Loa (eye worm) hypothetical protein 0.0062 0.0486 0.1792
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0082 0.0941
Plasmodium falciparum thioredoxin reductase 0.0057 0.0433 0.537
Trypanosoma cruzi hypothetical protein, conserved 0.036 0.3414 1
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0058 0.0063
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0014 0.0027
Leishmania major phosphatidylinositol 3-kinase, putative 0.0072 0.0577 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0134 0.2219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0315 0.5399
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0593 0.1653
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0066 0.0166
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0299 0.0292
Toxoplasma gondii target of rapamycin (TOR), putative 0.0072 0.0577 0.7185
Entamoeba histolytica hypothetical protein 0.0043 0.0299 0.2821
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.048 0.3672
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0279
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0066 0.0073
Echinococcus granulosus serine protein kinase ATM 0.004 0.0269 0.0262
Leishmania major hypothetical protein, conserved 0.0019 0.0058 0.0143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.0166
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.004 0.0269 0.4601
Entamoeba histolytica hypothetical protein 0.004 0.0269 0.2537
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0058 0.0051
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0072 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0249 0.0903

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 3.303 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4109 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 0.4611 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 1 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 1.1995 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8024 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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