Detailed information for compound 1422748

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.642 | Formula: C26H36N2OS
  • H donors: 0 H acceptors: 1 LogP: 5.75 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(N1CCN(CCC1=O)CCc1ccccc1)CSc1ccc(cc1)C)C
  • InChi: 1S/C26H36N2OS/c1-21(2)19-24(20-30-25-11-9-22(3)10-12-25)28-18-17-27(16-14-26(28)29)15-13-23-7-5-4-6-8-23/h4-12,21,24H,13-20H2,1-3H3
  • InChiKey: YRFNTVOZZFJNMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0054 0.0054
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0021 0.0061 0.0061
Echinococcus granulosus basement membrane specific heparan sulfate 0.0025 0.0091 0.0091
Echinococcus granulosus neuropeptide receptor A26 0.091 0.6487 0.6487
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0079 0.0097
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0117 0.0754
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.015 0.0194
Trypanosoma brucei polo-like protein kinase 0.0095 0.0599 0.3969
Echinococcus multilocularis phd:f box containing protein 0.002 0.0054 0.0054
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0153 0.0995
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.037 0.037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0361 0.0361
Brugia malayi hypothetical protein 0.0025 0.0091 0.0119
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0592 0.4184 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0026 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.2001 0.2001
Brugia malayi Thioredoxin reductase 0.0037 0.0181 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Trypanosoma brucei ISWI complex protein 0.0015 0.0021 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0117 0.0754
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0025 0.0091 0.0118
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0025 0.0091 0.0091
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0116 0.0749 0.4973
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0009 0.0031
Toxoplasma gondii SWI2/SNF2-containing protein 0.0041 0.0205 0.1015
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0052 0.0989
Schistosoma mansoni tar DNA-binding protein 0.0332 0.2305 0.2305
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0054 0.0054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0065 0.0079
Echinococcus granulosus importin subunit beta 1 0.0028 0.0116 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Leishmania major basic transcription factor 3a, putative 0.007 0.0415 0.2747
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0172 0.0222
Brugia malayi PHD-finger family protein 0.0028 0.0116 0.015
Brugia malayi beta-lactamase family protein 0.0036 0.017 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0262
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0025 0.0091 0.0118
Brugia malayi Doublecortin family protein 0.002 0.0052 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0031
Onchocerca volvulus 0.0025 0.0091 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0079 0.0498
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.0749 0.0971
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0528 0.2626
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0331 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0153 0.0747
Trypanosoma brucei DNA topoisomerase IA, putative 0.004 0.02 0.1308
Entamoeba histolytica hypothetical protein 0.0107 0.068 0.1625
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0599 0.0776
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.1502 0.1948
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0172 0.1118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0172 0.0222
Echinococcus multilocularis cpg binding protein 0.0155 0.1029 0.1029
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0077 0.01
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0165 0.0214
Mycobacterium ulcerans beta-lactamase 0.0036 0.017 0.0215
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.053 0.053
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0009 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.1254 0.897 0.897
Schistosoma mansoni bromodomain containing protein 0.0016 0.0024 0.0024
Schistosoma mansoni importin beta-1 0.0028 0.0116 0.0116
Schistosoma mansoni glutaminase 0.108 0.7712 0.7712
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.017 0.022
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.0184
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0014 0.0018
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0153 0.2767
Loa Loa (eye worm) RecQ helicase 0.0022 0.0069 0.0089
Loa Loa (eye worm) DEAH box polypeptide 35 0.051 0.3592 0.4658
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.017 0.022
Echinococcus granulosus low density lipoprotein receptor ldl 0.0025 0.0091 0.0091
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0025 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Toxoplasma gondii ABC1 family protein 0.0036 0.017 0.0839
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0054 0.0333
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0248 0.1223
Loa Loa (eye worm) hypothetical protein 0.0166 0.1111 0.1441
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.034 0.6206
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.2107 0.2732
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0361 0.0361
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.022 0.1502 0.7364
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0248 0.0316
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0153 0.0153
Echinococcus multilocularis snurportin 1 0.0304 0.2107 0.2107
Plasmodium vivax DNA topoisomerase 3, putative 0.004 0.02 0.3629
Giardia lamblia Fructose-bisphosphate aldolase 0.0592 0.4184 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0657 0.0657
Echinococcus multilocularis musashi 0.0027 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Brugia malayi jmjC domain containing protein 0.0202 0.1368 0.1774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0361 0.0464
Echinococcus multilocularis muscleblind protein 1 0.0296 0.2052 0.2052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.017 0.1108
Echinococcus granulosus GPCR family 2 0.0052 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.0025 0.0091 0.0091
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0248 0.451
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.007
Schistosoma mansoni lamin 0.0027 0.0104 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.034 0.0441
Mycobacterium tuberculosis Conserved protein 0.0036 0.017 0.0833
Plasmodium vivax hypothetical protein, conserved 0.0029 0.012 0.2164
Schistosoma mansoni zinc finger protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Echinococcus granulosus lysine specific demethylase 5A 0.0083 0.0509 0.0509
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0181 0.0235
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0021 0.0061 0.0061
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0172 0.0222
Onchocerca volvulus 0.0027 0.0104 0.0307
Loa Loa (eye worm) DNA topoisomerase III 0.004 0.02 0.0259
Loa Loa (eye worm) ICD-1 protein 0.007 0.0415 0.0539
Echinococcus granulosus dnaJ subfamily B 0.1254 0.897 0.897
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.017 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.2001 0.2001
Trypanosoma brucei unspecified product 0.0023 0.0079 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0172 0.0172
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0117 0.028
Schistosoma mansoni SET domain protein 0.0014 0.001 0.001
Plasmodium vivax JmjC domain containing protein 0.002 0.0054 0.0946
Brugia malayi jmjC domain containing protein 0.002 0.0054 0.007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0079 0.0079
Brugia malayi DNA topoisomerase III beta-1 0.0021 0.0061 0.0079
Mycobacterium ulcerans hypothetical protein 0.0029 0.0117 0.0147
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Echinococcus multilocularis neuropeptide s receptor 0.091 0.6487 0.6487
Schistosoma mansoni lipoxygenase 0.0118 0.0761 0.0761
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0025 0.0091 0.0091
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0116 0.0748
Loa Loa (eye worm) hypothetical protein 0.0106 0.0674 0.0873
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0117 0.0147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.017 0.0215
Loa Loa (eye worm) acetyltransferase 0.03 0.2075 0.269
Brugia malayi MH2 domain containing protein 0.0117 0.0752 0.0975
Echinococcus granulosus snurportin 1 0.0304 0.2107 0.2107
Trypanosoma cruzi ISWI complex protein 0.0015 0.0021 0.0116
Schistosoma mansoni hypothetical protein 0.0107 0.068 0.068
Brugia malayi hypothetical protein 0.0016 0.0027 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.015 0.0194
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.034 0.0441
Leishmania major DNA polymerase eta, putative 0.0023 0.0079 0.0498
Loa Loa (eye worm) glutathione reductase 0.0037 0.0181 0.0235
Echinococcus granulosus zinc finger protein 0.0016 0.0024 0.0024
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0248 0.1232
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0657 0.0852
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.015 0.0194
Leishmania major DNA topoisomerase 1A 0.004 0.02 0.1308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0152
Plasmodium vivax SET domain protein, putative 0.0064 0.037 0.6747
Echinococcus granulosus Solute carrier family 22 5 0.1031 0.7355 0.7355
Schistosoma mansoni hypothetical protein 0.0052 0.0284 0.0284
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0054 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.2001 0.2001
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0028
Brugia malayi PAS domain containing protein 0.0048 0.0254 0.033
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0355 0.0461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.2001 0.2001
Treponema pallidum fructose-bisphosphate aldolase 0.0592 0.4184 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0289 0.1998 0.2587
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0287 0.1984 1
Brugia malayi TAR-binding protein 0.0332 0.2305 0.2989
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0084
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0342 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0248 0.1628
Echinococcus granulosus L aminoadipate semialdehyde 0.0166 0.1111 0.1111
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0355 0.6485
Schistosoma mansoni hypothetical protein 0.002 0.0056 0.0056
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.0415 0.2747
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0166 0.1111 0.1441
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0657 0.1563
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.017 0.0833
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0749 0.0749
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.1502 0.1948
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0079 0.0102
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0657 0.0657
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0361 0.0361
Entamoeba histolytica hypothetical protein 0.0107 0.068 0.1625
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0084
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0657 0.4361
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0113 0.0147
Leishmania major hypothetical protein, conserved 0.0025 0.0091 0.0584
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0509 0.0509
Brugia malayi jmjC domain containing protein 0.0083 0.0509 0.0661
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0117 0.0147
Loa Loa (eye worm) hypothetical protein 0.006 0.0342 0.0443
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0262
Echinococcus granulosus dna polymerase kappa 0.0023 0.0079 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0091 0.0584
Echinococcus granulosus cpg binding protein 0.0155 0.1029 0.1029
Schistosoma mansoni rab6-interacting 0.002 0.0052 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0079 0.0102
Loa Loa (eye worm) hypothetical protein 0.0175 0.1176 0.1525
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.034 0.0804
Echinococcus granulosus bloom syndrome protein 0.0022 0.0069 0.0069
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0657 0.4361
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0054 0.0333
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0289 0.1998 1
Brugia malayi beta-NAC-like protein 0.007 0.0415 0.0539
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0091 0.0584
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.1502 0.1948
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0104 0.0135
Schistosoma mansoni inositol monophosphatase 0.0036 0.0172 0.0172
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0248 0.1232
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0494 0.118
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0004
Brugia malayi hypothetical protein 0.0107 0.068 0.0881
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0117 0.0754
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0657 0.33
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.1176 0.3462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.2001 0.2001
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0054 0.1019
Echinococcus granulosus tumor protein p63 0.0408 0.2858 0.2858
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0079 0.0102
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0599 0.0599
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0056 0.0261
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0449 0.0449
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0054 0.007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.03 0.2075 0.2075
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0116 0.0749 0.0749
Brugia malayi PHD-finger family protein 0.0062 0.0355 0.0461
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.1502 1
Trichomonas vaginalis glutaminase, putative 0.108 0.7712 1
Schistosoma mansoni hypothetical protein 0.069 0.4893 0.4893
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Schistosoma mansoni 6-phosphofructokinase 0.022 0.1502 0.1502
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0172 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0657 0.0657
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0004
Echinococcus granulosus lamin dm0 0.0027 0.0104 0.0104
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0289 0.1998 1
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0052 0.0919
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0657 0.0852
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0355 0.1775
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0153 0.0153
Plasmodium falciparum phd finger protein, putative 0.0062 0.0355 0.7176
Loa Loa (eye worm) hypothetical protein 0.009 0.0561 0.0727
Schistosoma mansoni lipoxygenase 0.0082 0.0505 0.0505
Echinococcus multilocularis tumor protein p63 0.0408 0.2858 0.2858
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Brugia malayi Cytochrome P450 family protein 0.0028 0.0113 0.0147
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.1091 0.1414
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0284 0.0368
Trypanosoma brucei DNA topoisomerase III, putative 0.004 0.02 0.1308
Loa Loa (eye worm) CXXC zinc finger family protein 0.0146 0.0968 0.1256
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.2976 0.3859
Entamoeba histolytica phosphofructokinase, putative 0.022 0.1502 0.359
Echinococcus granulosus basement membrane specific heparan sulfate 0.0025 0.0091 0.0091
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0172 0.1118
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0657 0.4361
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0289 0.2001 0.2594
Echinococcus granulosus single minded 2 0.0035 0.0165 0.0165
Schistosoma mansoni protein phosphatase 2C 0.002 0.0054 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.1397 1 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0113 0.0147
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0184 0.0184
Onchocerca volvulus 0.002 0.0052 0.0154
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0091 0.0442
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0113 0.0147
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0017 0.0275
Brugia malayi RNA recognition motif domain containing protein 0.0332 0.2305 0.2989
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0248 0.0584
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0153 0.0753
Schistosoma mansoni intermediate filament proteins 0.0027 0.0104 0.0104
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0415 0.2747
Brugia malayi hypothetical protein 0.002 0.0052 0.0068
Brugia malayi N-terminal motif family protein 0.0175 0.1176 0.1525
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.037 0.037
Onchocerca volvulus 0.006 0.0342 0.1006
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0068
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0528 0.2626
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0065 0.1238
Entamoeba histolytica DNA topoisomerase III, putative 0.004 0.02 0.0478
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0749 0.0967
Trypanosoma cruzi DNA topoisomerase IA, putative 0.004 0.02 0.1308
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0547 0.0709
Brugia malayi Importin beta-1 subunit 0.0028 0.0116 0.015
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0079 0.0188
Schistosoma mansoni cpg binding protein 0.0155 0.1029 0.1029
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.017 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0153 0.0153
Chlamydia trachomatis DNA topoisomerase I 0.0081 0.0495 1
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0021 0.0061 0.0079
Brugia malayi Pre-SET motif family protein 0.0064 0.037 0.0479
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0117 0.0147
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0069 0.0089
Toxoplasma gondii NAC domain-containing protein 0.007 0.0415 0.2078
Echinococcus granulosus phd:f box containing protein 0.002 0.0054 0.0054
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0547 0.2741
Brugia malayi hypothetical protein 0.002 0.0052 0.0068
Loa Loa (eye worm) glutaminase 2 0.108 0.7712 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.015 0.0194
Schistosoma mansoni jumonji domain containing protein 0.002 0.0054 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.034 0.0441
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Onchocerca volvulus 0.0025 0.0091 0.0267
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0113 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0065 0.0305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0117 0.028
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0117 0.0147
Echinococcus granulosus lamin 0.0027 0.0104 0.0104
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0599 0.3969
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0004 0.0029
Onchocerca volvulus Alhambra homolog 0.0062 0.0355 0.1047
Leishmania major protein kinase, putative 0.0014 0.0009 0.0031
Trichomonas vaginalis hypothetical protein 0.0018 0.0039 0.005
Echinococcus granulosus jumonji domain containing protein 0.0086 0.053 0.053
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0117 0.0152
Brugia malayi Cytochrome P450 family protein 0.0029 0.0121 0.0157
Giardia lamblia DNA topoisomerase III 0.004 0.02 0.0469
Leishmania major protein kinase, putative 0.0017 0.0036 0.0213
Mycobacterium ulcerans DNA topoisomerase I 0.004 0.02 0.0254
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0135
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0284 0.0284
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0091 0.1785
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0254 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Trypanosoma cruzi DNA topoisomerase IA, putative 0.004 0.02 0.1308
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.037 0.1847
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.037 0.037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0202 0.1368 0.1368
Echinococcus multilocularis 6 phosphofructokinase 0.022 0.1502 0.1502
Schistosoma mansoni 6-phosphofructokinase 0.022 0.1502 0.1502
Echinococcus granulosus RUN 0.002 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.016 0.1065 0.1381
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0153 0.0153
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0153 0.3043
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0547 1
Onchocerca volvulus 0.0025 0.0091 0.0267
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0113 0.0729
Schistosoma mansoni tar DNA-binding protein 0.0332 0.2305 0.2305
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.034 0.1698
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.017 0.022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0091 0.0584
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.004 0.02 0.0259
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.004 0.02 0.0441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0056 0.0261
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0144 0.0144
Onchocerca volvulus 0.0025 0.0091 0.0267
Onchocerca volvulus Arrow homolog 0.0025 0.0091 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0054 0.007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0189 0.0189
Echinococcus multilocularis muscleblind protein 0.0296 0.2052 0.2052
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.0415 0.0993
Onchocerca volvulus 0.0064 0.037 0.1089
Mycobacterium leprae conserved hypothetical protein 0.0036 0.017 0.0282
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0153 0.0153
Brugia malayi enteropeptidase precursor 0.0025 0.0091 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.2001 0.2001
Schistosoma mansoni microtubule-associated protein tau 0.1397 1 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Echinococcus granulosus tar DNA binding protein 0.0332 0.2305 0.2305
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0248 0.4971
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0052 0.0052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0039 0.005
Echinococcus granulosus low density lipoprotein receptor protein 0.0025 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.017 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0117 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0361 0.0361
Onchocerca volvulus 0.0036 0.017 0.0501
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0528 0.2183
Echinococcus granulosus neuropeptide s receptor 0.091 0.6487 0.6487
Brugia malayi MAP kinase sur-1 0.0103 0.0657 0.0852
Loa Loa (eye worm) histone methyltransferase 0.0048 0.0254 0.0329
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0547 0.2741
Schistosoma mansoni hypothetical protein 0.069 0.4893 0.4893
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0202 0.1368 0.1368
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0068
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0153 0.0753
Echinococcus multilocularis transcription factor btf3 0.007 0.0415 0.0415
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0069 0.0089
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0052 0.0052
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0172 0.1118
Echinococcus multilocularis neuropeptide receptor A26 0.091 0.6487 0.6487
Trichomonas vaginalis helicase, putative 0.0033 0.015 0.0194
Brugia malayi RNA binding protein 0.0332 0.2305 0.2989
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.0415 0.7588
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.1091 0.1414
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.022 0.1502 0.3584
Echinococcus multilocularis zinc finger protein 0.0016 0.0024 0.0024
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0116 0.0116
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0069 0.0089
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0361 0.1805
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0025 0.0091 0.0091
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.034 0.6206
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0248 0.1628
Echinococcus multilocularis GPCR, family 2 0.0052 0.0284 0.0284
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0289 0.2001 0.2594
Brugia malayi SET domain containing protein 0.0014 0.001 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0153 0.0995
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0054 0.0054
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0693 0.0898
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0415 0.0539
Onchocerca volvulus 0.002 0.0052 0.0154
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0054 0.0333
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0592 0.4184 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0026 0.0149
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0081 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0479
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0079 0.0498
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0113 0.0729
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0172 0.3414
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0761 0.0761
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0296 0.2052 0.2661
Loa Loa (eye worm) inositol-1 0.0036 0.0172 0.0222
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0313 0.2171 0.2171
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0749 0.0749
Schistosoma mansoni rab6-interacting 0.002 0.0052 0.0052
Echinococcus multilocularis peregrin 0.0069 0.0408 0.0408
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0752 0.0975
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0117 0.0147
Loa Loa (eye worm) RNA binding protein 0.0332 0.2305 0.2989
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.034 0.6852
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.022
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0181 0.3279
Echinococcus granulosus low density lipoprotein receptor ldl 0.0025 0.0091 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0004 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.017 0.022
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0079 0.0102
Schistosoma mansoni transcription factor btf3 0.007 0.0415 0.0415
Brugia malayi Bromodomain containing protein 0.0069 0.0408 0.053
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0025 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0047 0.0248 0.0593
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Echinococcus granulosus muscleblind protein 0.0296 0.2052 0.2052
Schistosoma mansoni eyes absent homolog 0.009 0.0561 0.0561
Onchocerca volvulus 0.0036 0.017 0.0501
Schistosoma mansoni bromodomain containing protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0749 0.0967
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0284 0.0284
Brugia malayi CXXC zinc finger family protein 0.0146 0.0968 0.1256
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0048 0.0254 0.0254
Onchocerca volvulus 0.0025 0.0091 0.0267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0079 0.0374
Loa Loa (eye worm) glutaminase 0.108 0.7712 1
Entamoeba histolytica hypothetical protein 0.0017 0.0035 0.0084
Mycobacterium leprae Probable lipase LipE 0.0036 0.017 0.0282
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0117 0.0567
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0004 0.0029
Trypanosoma brucei trypanothione reductase 0.0037 0.0181 0.1181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.015 0.0194
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.017 0.0833
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0361 0.1792
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Mycobacterium tuberculosis Probable reductase 0.0085 0.0528 0.2626
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0254 0.033
Trypanosoma cruzi DNA topoisomerase III, putative 0.004 0.02 0.1308
Echinococcus multilocularis lamin dm0 0.0027 0.0104 0.0104
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0054 0.007
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0113 0.0729
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0065 0.124
Schistosoma mansoni polycystin 1-related 0.002 0.0052 0.0052
Brugia malayi basement membrane proteoglycan precursor 0.0025 0.0091 0.0118
Loa Loa (eye worm) hypothetical protein 0.0112 0.0717 0.093
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.037 0.037
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.017 0.022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Echinococcus granulosus geminin 0.069 0.4893 0.4893
Leishmania major importin beta-1 subunit, putative 0.0023 0.0077 0.0488
Echinococcus granulosus transcription factor btf3 0.007 0.0415 0.0415
Schistosoma mansoni hypothetical protein 0.0025 0.0091 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0021 0.0028
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0761 0.0761
Brugia malayi Bromodomain containing protein 0.0016 0.0024 0.0031
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0597 0.255
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.017 0.017
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0025 0.0091 0.0267
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0599 0.1763
Leishmania major ATP-dependent phosphofructokinase 0.022 0.1502 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0114 0.0114
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0009 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.015 0.0194
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.034 0.6852
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.004 0.02 0.0259
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0025 0.0091 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0284 0.0368
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0415 0.2747
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0657 0.0852
Entamoeba histolytica DNA topoisomerase III, putative 0.0021 0.0061 0.0146
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0717 0.093
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.015
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.034 0.0813
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0025 0.0091 0.0091
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0079 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0052 0.0052
Schistosoma mansoni kinase 0.0049 0.0263 0.0263
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0054 0.0054
Brugia malayi Pre-SET motif family protein 0.0424 0.2976 0.3859
Brugia malayi jmjC domain containing protein 0.002 0.0054 0.007
Entamoeba histolytica hypothetical protein 0.0107 0.068 0.1625
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.068 0.068
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0069 0.0069
Brugia malayi Inositol-1 0.0036 0.0172 0.0222
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0079 0.0374
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.017 0.022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0113 0.0147
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0657 0.4361
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0284 0.0284
Leishmania major trypanothione reductase 0.0037 0.0181 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0415 0.0539
Echinococcus multilocularis L aminoadipate semialdehyde 0.0166 0.1111 0.1111
Echinococcus granulosus intermediate filament protein 0.0027 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0052 0.0284 0.0284
Brugia malayi intermediate filament protein 0.0027 0.0104 0.0135
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0597 0.2972
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0494 0.1172
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.017 0.0833
Toxoplasma gondii 6-phosphofructokinase 0.006 0.034 0.1698
Brugia malayi CUB domain containing protein 0.0025 0.0091 0.0118
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0355 0.1775
Schistosoma mansoni lamin 0.0027 0.0104 0.0104
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0079 0.0498
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0248 0.4971
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0091 0.0118
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0039 0.0189 0.0189
Echinococcus multilocularis rho GTPase activating protein 20 0.004 0.02 0.02
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.034 0.0804
Leishmania major DNA topoisomerase III, putative 0.0021 0.0061 0.0382
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0025 0.0091 0.0091
Schistosoma mansoni myst-related protein 0.0017 0.0035 0.0035
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0189 0.0189
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0054 0.0054
Mycobacterium ulcerans 6-phosphofructokinase 0.022 0.1502 0.1943
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0172 0.041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0078 0.0078
Mycobacterium tuberculosis Conserved protein 0.0036 0.017 0.0833
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0065 0.1145
Loa Loa (eye worm) hypothetical protein 0.0052 0.0284 0.0368
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.017 0.017
Schistosoma mansoni jumonji domain containing protein 0.016 0.1069 0.1069
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0049 0.0929
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0025 0.0091 0.0091
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0079 0.0097
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0016 0.0061
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0599 0.0776
Entamoeba histolytica phosphofructokinase, putative 0.022 0.1502 0.359
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0048
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.0052
Trypanosoma brucei protein kinase, putative 0.0103 0.0657 0.4361
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Schistosoma mansoni hypothetical protein 0.0112 0.0717 0.0717
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0355 0.0355
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.017 0.0833
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0119
Toxoplasma gondii thioredoxin reductase 0.0037 0.0181 0.0893
Loa Loa (eye worm) hypothetical protein 0.0163 0.1091 0.1414
Schistosoma mansoni tar DNA-binding protein 0.0332 0.2305 0.2305
Brugia malayi Probable ATP-dependent helicase DHX35 0.051 0.3592 0.4658
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.037 0.037
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0025 0.0091 0.0091
Leishmania major hypothetical protein, conserved 0.002 0.0054 0.0333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.2001 0.2001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0079 0.0102
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0166 0.1111 0.1111
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0528 0.2626
Loa Loa (eye worm) phosphofructokinase 0.022 0.1502 0.1948
Plasmodium vivax importin-beta 2, putative 0.0028 0.0116 0.2087
Trichomonas vaginalis set domain proteins, putative 0.0483 0.3396 0.4404
Brugia malayi hypothetical protein 0.016 0.1065 0.1381
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0054 0.0252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0509 0.0509
Schistosoma mansoni hypothetical protein 0.0062 0.0355 0.0355
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0361 0.0464
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0016 0.0024 0.0024
Onchocerca volvulus 0.0035 0.0165 0.0486
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0361 0.2385
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.157 0.7855
Plasmodium falciparum glutathione reductase 0.0037 0.0181 0.3612
Plasmodium falciparum DNA topoisomerase 3, putative 0.004 0.02 0.4002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0077 0.01
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0332 0.2305 0.2989
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.034 0.0441
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.022
Leishmania major cytochrome p450-like protein 0.0028 0.0113 0.0729
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Brugia malayi RNA, U transporter 1 0.0081 0.0495 0.0642
Onchocerca volvulus 0.0016 0.0027 0.0081
Onchocerca volvulus 0.0014 0.001 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0056 0.0345
Giardia lamblia PHD finger protein 15 0.0062 0.0355 0.0841
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0077 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0104 0.0135
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0248 0.0696
Brugia malayi beta-lactamase family protein 0.0036 0.017 0.022
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.0415 0.8402
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.022
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0181 0.1181
Echinococcus multilocularis lamin 0.0027 0.0104 0.0104
Mycobacterium tuberculosis Conserved protein 0.0036 0.017 0.0833
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.017 0.0833
Leishmania major DNA topoisomerase III, putative 0.0081 0.0495 0.3276
Schistosoma mansoni hypothetical protein 0.0052 0.0284 0.0284
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.017 0.017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0597 0.2972
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.034 0.1698
Giardia lamblia Kinase, PLK 0.0095 0.0599 0.1423
Brugia malayi POT family protein 0.0081 0.0497 0.0644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0262
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.068 0.068
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0172 0.0846
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0657 0.0657
Mycobacterium tuberculosis DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-c 0.0019 0.0049 0.0226
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0121 0.0157
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0144 0.0703
Plasmodium vivax hypothetical protein, conserved 0.0036 0.017 0.3079
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0153 0.0995
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0165 0.0165
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0509 0.0661
Plasmodium vivax glutathione reductase, putative 0.0037 0.0181 0.3279
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0091 0.1635
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0056 0.0345
Echinococcus multilocularis RUN 0.002 0.0052 0.0052
Trypanosoma cruzi DNA topoisomerase III, putative 0.0021 0.0061 0.0382
Loa Loa (eye worm) POT family protein 0.0081 0.0497 0.0644
Schistosoma mansoni inositol monophosphatase 0.0036 0.0172 0.0172
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0752 0.0975
Loa Loa (eye worm) hypothetical protein 0.0296 0.2052 0.2661
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.017 0.0833
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0657 0.0657
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.4184 0.5425
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0248 0.0316
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0657 0.4361
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.022
Plasmodium falciparum zinc finger protein, putative 0.0017 0.0035 0.0634
Trypanosoma brucei DNA topoisomerase III, putative 0.0021 0.0061 0.0382
Brugia malayi 6-phosphofructokinase 0.022 0.1502 0.1948
Treponema pallidum DNA topoisomerase I (topA) 0.0081 0.0495 0.1174
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0284 0.0368
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0079 0.0498
Loa Loa (eye worm) hypothetical protein 0.009 0.0561 0.0727
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0494 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0052 0.0052
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0025 0.0091 0.0118
Loa Loa (eye worm) doublecortin family protein 0.002 0.0052 0.0068
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.012 0.2373
Brugia malayi phosphofructokinase 0.022 0.1502 0.1948
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0657 0.0852
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.017 0.1108
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0153 0.0198
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0599 0.1431
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Echinococcus granulosus mixed lineage leukemia protein mll 0.0039 0.0189 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Toxoplasma gondii DNA topoisomerase family protein 0.004 0.02 0.099
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0025 0.0091 0.0118
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0004 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.034 0.0441
Loa Loa (eye worm) hypothetical protein 0.0026 0.0101 0.013
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0657 0.0852
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0657 0.4361
Trichomonas vaginalis esterase, putative 0.0036 0.017 0.022
Echinococcus granulosus DNA topoisomerase 3 alpha 0.004 0.02 0.02
Trypanosoma cruzi DNA topoisomerase III, putative 0.004 0.02 0.1308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0031
Mycobacterium ulcerans lipase LipD 0.0036 0.017 0.0215
Echinococcus multilocularis geminin 0.069 0.4893 0.4893
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Schistosoma mansoni cpg binding protein 0.0155 0.1029 0.1029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0117 0.0567
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0184 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.1091 0.1414
Onchocerca volvulus 0.0027 0.0104 0.0307
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.068 0.068
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0547 0.0547
Schistosoma mansoni tar DNA-binding protein 0.0332 0.2305 0.2305
Plasmodium falciparum importin beta, putative 0.0028 0.0116 0.2287
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Brugia malayi hypothetical protein 0.009 0.0561 0.0727
Brugia malayi glutathione reductase 0.0037 0.0181 0.0235
Echinococcus multilocularis low density lipoprotein receptor protein 0.0025 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0084
Brugia malayi hypoxia-induced factor 1 0.0147 0.0975 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0415 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.1502 0.1948
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0054 0.0054
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Entamoeba histolytica hypothetical protein 0.007 0.0415 0.0993
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0079 0.0079
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0153 0.0198
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Onchocerca volvulus 0.0146 0.0968 0.2851
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0081 0.0495 0.0495
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0153 0.0995
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0048 0.0254 0.0254
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.015 0.0194
Onchocerca volvulus 0.0025 0.0091 0.0267
Brugia malayi 6-phosphofructokinase 0.022 0.1502 0.1948
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0062 0.0356 0.1778
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0026 0.0149
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0054 0.0252
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.034 0.0441
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0025 0.0091 0.0267
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Echinococcus granulosus peregrin 0.0069 0.0408 0.0408
Trypanosoma brucei unspecified product 0.0016 0.0026 0.0149
Leishmania major DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.022
Entamoeba histolytica phosphofructokinase, putative 0.022 0.1502 0.359
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0025 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0152
Schistosoma mansoni hypothetical protein 0.0052 0.0284 0.0284
Onchocerca volvulus 0.0021 0.0061 0.018
Schistosoma mansoni myst-related protein 0.0017 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0332 0.2305 0.2305
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.015 0.0194
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0355 0.0355
Schistosoma mansoni cpg binding protein 0.0146 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0152
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.017 0.0833
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.022 0.1502 0.7513
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0116 0.0566
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0165 0.0209
Brugia malayi beta-lactamase 0.0036 0.017 0.022
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0116 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Schistosoma mansoni loxhd1 0.002 0.0052 0.0052
Brugia malayi jmjC domain containing protein 0.002 0.0054 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.034 0.0441
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0547 0.0709
Schistosoma mansoni single-minded 0.0048 0.0254 0.0254
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.1502 0.1948
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0004 0.0005
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Plasmodium falciparum thioredoxin reductase 0.0037 0.0181 0.3612
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.037 0.037
Onchocerca volvulus 0.0483 0.3396 1
Loa Loa (eye worm) TAR-binding protein 0.0332 0.2305 0.2989
Brugia malayi F/Y-rich N-terminus family protein 0.0067 0.0395 0.0512
Loa Loa (eye worm) hypothetical protein 0.0062 0.0355 0.0461
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0528 0.2626
Schistosoma mansoni hypothetical protein 0.1254 0.897 0.897
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0599 0.3969
Loa Loa (eye worm) hypothetical protein 0.051 0.3592 0.4658
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.037 0.037
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0021 0.0061 0.0061
Trypanosoma brucei unspecified product 0.0016 0.0026 0.0149
Brugia malayi acetyltransferase, GNAT family protein 0.03 0.2075 0.269
Giardia lamblia DNA topoisomerase III 0.0021 0.0061 0.0137
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0116 0.0749 0.3737
Brugia malayi isocitrate dehydrogenase 0.0034 0.0153 0.0198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0262
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.015 0.0194
Brugia malayi Muscleblind-like protein 0.0296 0.2052 0.2661
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0335 0.0335
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.017 0.1108
Mycobacterium ulcerans glutaminase 0.108 0.7712 1
Brugia malayi AF-10 protein 0.002 0.0056 0.0072
Brugia malayi DNA topoisomerase III 0.004 0.02 0.0259
Loa Loa (eye worm) beta-lactamase 0.0036 0.017 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.1502 0.1948
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0599 0.3969
Leishmania major hypothetical protein, conserved 0.0036 0.017 0.1108
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0172 0.1118
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0181 0.0887
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0284 0.0284
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0054 0.0054
Mycobacterium ulcerans hypothetical protein 0.0036 0.017 0.0215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0153 0.0153
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0361 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0291 0.2014 0.2014
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0599 0.0776
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0597 0.2972
Giardia lamblia DINP protein human, muc B family 0.0023 0.0079 0.0178
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0117 0.0152
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.034 0.6866
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0254 0.033
Brugia malayi glutaminase DH11.1 0.108 0.7712 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0079 0.0498
Onchocerca volvulus 0.0036 0.017 0.0501
Brugia malayi jmjC domain containing protein 0.002 0.0054 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0117 0.0147
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0528 0.2626
Echinococcus granulosus 6 phosphofructokinase 0.022 0.1502 0.1502
Onchocerca volvulus 0.0029 0.0117 0.0345
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0005
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0117 0.028
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0025 0.0091 0.0091
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0025 0.0091 0.0091
Schistosoma mansoni DNA polymerase eta 0.0023 0.0079 0.0079
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0657 0.4361
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0355 0.0355
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0079 0.0498
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0091 0.1785
Onchocerca volvulus 0.0166 0.1111 0.3271
Schistosoma mansoni hypothetical protein 0.0304 0.2107 0.2107
Echinococcus multilocularis tar DNA binding protein 0.0332 0.2305 0.2305
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0079 0.0498
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0599 0.0599
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0052 0.0052
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0248 0.4981
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.083 0.1076
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0025 0.0091 0.0118
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.034 0.6866
Schistosoma mansoni phd/f-box containing protein 0.002 0.0054 0.0054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0153 0.0153
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0079 0.0102
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.1502 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0079 0.0079
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0975 0.1265
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0117 0.0152
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0172 0.0172
Brugia malayi PHD-finger family protein 0.0016 0.0024 0.0031
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.03 0.2075 0.2075
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0077 0.01
Entamoeba histolytica hypothetical protein 0.0107 0.068 0.1625
Echinococcus multilocularis dna polymerase eta 0.0023 0.0079 0.0079
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0104 0.0135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0153 0.0995
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0079 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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