Detailed information for compound 1430146

Basic information

Technical information
  • TDR Targets ID: 1430146
  • Name: 2-(4-methyl-1-oxopyrrolo[1,2-d][1,2,4]triazin -2-yl)-N-(3-piperidin-1-ylpropyl)acetamide
  • MW: 331.413 | Formula: C17H25N5O2
  • H donors: 1 H acceptors: 2 LogP: 0.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1nc(C)n2c(c1=O)ccc2)NCCCN1CCCCC1
  • InChi: 1S/C17H25N5O2/c1-14-19-22(17(24)15-7-5-12-21(14)15)13-16(23)18-8-6-11-20-9-3-2-4-10-20/h5,7,12H,2-4,6,8-11,13H2,1H3,(H,18,23)
  • InChiKey: JZPCZEDVAGEIIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methyl-1-oxo-pyrrolo[1,2-d][1,2,4]triazin-2-yl)-N-[3-(1-piperidyl)propyl]acetamide
  • 2-(4-methyl-1-oxo-2-pyrrolo[1,2-d][1,2,4]triazinyl)-N-[3-(1-piperidyl)propyl]acetamide
  • 2-(1-keto-4-methyl-pyrrolo[1,2-d][1,2,4]triazin-2-yl)-N-(3-piperidinopropyl)acetamide
  • 2-(4-methyl-1-oxo-pyrrolo[1,2-d][1,2,4]triazin-2-yl)-N-(3-piperidin-1-ylpropyl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0164 0.0803 1
Schistosoma mansoni myotubularin-related protein 0.0068 0.0256 0.038
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Entamoeba histolytica protein kinase, putative 0.0081 0.0329 0.0329
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0329 0.0329
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0068 0.0256 0.038
Brugia malayi Hr1 repeat family protein 0.0588 0.3211 0.3211
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0164 0.0803 1
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Echinococcus granulosus oxysterol binding protein 3 0.0068 0.0256 0.038
Mycobacterium ulcerans carboxylesterase, LipT 0.0164 0.0803 1
Entamoeba histolytica hypothetical protein, conserved 0.0068 0.0256 0.0256
Loa Loa (eye worm) oxysterol binding protein 0.0068 0.0256 0.0256
Plasmodium vivax PH domain containing protein 0.0068 0.0256 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Onchocerca volvulus 0.0164 0.0803 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.114 0.6349 1
Echinococcus multilocularis oxysterol binding protein 3 0.0068 0.0256 0.038
Schistosoma mansoni hypothetical protein 0.0068 0.0256 0.038
Echinococcus multilocularis DCC interacting protein 13 beta 0.0068 0.0256 0.038
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0068 0.0256 0.038
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.097 0.5385 0.7998
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0803 0.1192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0185 0.0185
Brugia malayi Dynamin 0.0068 0.0256 0.0256
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0081 0.0329 1
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Brugia malayi Plekhf2 protein 0.0068 0.0256 0.0256
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0588 0.3211 0.4769
Echinococcus multilocularis Rho GTPase activating protein 24 0.0068 0.0256 0.038
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0068 0.0256 0.0403
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Entamoeba histolytica protein kinase, putative 0.0588 0.3211 0.3211
Trichomonas vaginalis AGC family protein kinase 0.0588 0.3211 0.3211
Echinococcus granulosus cGMP dependent protein kinase 1 0.005 0.0157 0.0233
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0068 0.0256 0.038
Echinococcus multilocularis protein kinase c iota type 0.0588 0.3211 0.4769
Toxoplasma gondii hypothetical protein 0.0068 0.0256 0.0266
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0068 0.0256 0.038
Schistosoma mansoni serine/threonine-protein kinase 0.1207 0.6733 1
Echinococcus granulosus Oxysterol binding protein 11 0.0068 0.0256 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Loa Loa (eye worm) rho-GTPase-activating 0.0068 0.0256 0.0256
Leishmania major protein kinase, putative 0.0081 0.0329 1
Schistosoma mansoni serine/threonine-protein kinase 0.1207 0.6733 1
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Loa Loa (eye worm) carboxylesterase 0.097 0.5385 0.5385
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0081 0.0329 0.0488
Schistosoma mansoni gliotactin 0.0164 0.0803 0.1192
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.114 0.6349 0.9429
Trypanosoma cruzi rac serine-threonine kinase, putative 0.114 0.6349 0.9429
Toxoplasma gondii AtPH1 family protein 0.0068 0.0256 0.0266
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Plasmodium falciparum PH domain-containing protein, putative 0.0068 0.0256 0.0403
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Echinococcus multilocularis oxysterol binding protein 9 0.0068 0.0256 0.038
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.005 0.0157 0.0163
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Schistosoma mansoni goodpasture antigen-binding protein 0.0068 0.0256 0.038
Brugia malayi hypothetical protein 0.003 0.0044 0.0044
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0068 0.0256 0.0256
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0068 0.0256 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0068 0.0256 0.038
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Onchocerca volvulus 0.0164 0.0803 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0068 0.0256 0.038
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0588 0.3211 0.4769
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0329 0.0329
Loa Loa (eye worm) Plekhf2 protein 0.0068 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Entamoeba histolytica ARF GTPase activating protein, putative 0.0068 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0044 0.0046
Entamoeba histolytica protein kinase, putative 0.1782 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0185 0.0275
Echinococcus multilocularis neuroligin 0.0164 0.0803 0.1192
Brugia malayi Carboxylesterase family protein 0.0164 0.0803 0.0803
Schistosoma mansoni serine/threonine kinase 0.0588 0.3211 0.4769
Toxoplasma gondii phosphatidylinositol transfer protein 0.0068 0.0256 0.0266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0185 0.0275
Echinococcus granulosus serine/threonine protein kinase 0.1207 0.6733 1
Trypanosoma brucei PH domain containing protein, putative 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0803 0.1192
Schistosoma mansoni zinc finger protein 0.0068 0.0256 0.038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5437 0.8075
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0081 0.0329 0.0329
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0081 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0081 0.0329 0.0329
Echinococcus granulosus Pleckstrin y 0.0068 0.0256 0.038
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0081 0.0329 0.0329
Brugia malayi Variant SH3 domain containing protein 0.0068 0.0256 0.0256
Entamoeba histolytica hypothetical protein 0.0068 0.0256 0.0256
Trypanosoma cruzi PH domain containing protein, putative 0.0068 0.0256 0.038
Echinococcus granulosus BC026374 protein S09 family 0.0164 0.0803 0.1192
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Brugia malayi Variant SH3 domain containing protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) uncoordinated protein 104 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0068 0.0256 0.0256
Brugia malayi Syntrophin-1 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0185 0.0275
Entamoeba histolytica hypothetical protein 0.0383 0.2048 0.2048
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Brugia malayi Cytohesin 3 0.0068 0.0256 0.0256
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Giardia lamblia Kinase, AGC PKA 0.114 0.6349 1
Echinococcus multilocularis pleckstrin y domain containing family A 0.0068 0.0256 0.038
Entamoeba histolytica hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis serine:threonine protein kinase 38 0.0588 0.3211 0.4769
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0068 0.0256 0.0403
Echinococcus multilocularis nervana 2 0.1127 0.6275 0.932
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0044 0.0069
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0068 0.0256 0.038
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0588 0.3211 0.4769
Schistosoma mansoni goodpasture antigen-binding protein 0.0068 0.0256 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Schistosoma mansoni oxysterol-binding protein 1 0.0068 0.0256 0.038
Toxoplasma gondii AGC kinase 0.1714 0.9615 1
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Entamoeba histolytica PH domain containing protein 0.0068 0.0256 0.0256
Echinococcus multilocularis cGMP dependent protein kinase 1 0.005 0.0157 0.0233
Brugia malayi Oxysterol binding protein 0.0068 0.0256 0.0256
Schistosoma mansoni neuroligin 3 (S09 family) 0.0164 0.0803 0.1192
Leishmania major hypothetical protein, conserved 0.0068 0.0256 0.777
Echinococcus granulosus myotubularin protein 13 0.0068 0.0256 0.038
Entamoeba histolytica protein kinase, putative 0.0081 0.0329 0.0329
Echinococcus granulosus cGMP dependent protein kinase 1 0.005 0.0157 0.0233
Schistosoma mansoni zinc finger protein 0.0068 0.0256 0.038
Schistosoma mansoni dynamin 0.0068 0.0256 0.038
Loa Loa (eye worm) PH domain-containing protein 0.0068 0.0256 0.0256
Echinococcus granulosus NDR protein kinase 0.0588 0.3211 0.4769
Trichomonas vaginalis spcc417.12 protein, putative 0.0164 0.0803 0.0803
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0588 0.3211 0.4769
Loa Loa (eye worm) hypothetical protein 0.097 0.5385 0.5385
Echinococcus granulosus neuroligin 0.0164 0.0803 0.1192
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0588 0.3211 0.4769
Echinococcus multilocularis Glutaredoxin protein 5 0.1127 0.6275 0.932
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Entamoeba histolytica hypothetical protein 0.0068 0.0256 0.0256
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0068 0.0256 0.038
Brugia malayi Dynamin 0.0068 0.0256 0.0256
Echinococcus multilocularis serine threonine protein kinase 0.0588 0.3211 0.4769
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0081 0.0329 0.0488
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0068 0.0256 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Echinococcus granulosus cGMP dependent protein kinase 0.005 0.0157 0.0233
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Echinococcus granulosus acetylcholinesterase 0.097 0.5385 0.7998
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0068 0.0256 0.0256
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0068 0.0256 0.0256
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0081 0.0329 0.0342
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0068 0.0256 0.038
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0157 0.0233
Entamoeba histolytica PH domain containing protein 0.0068 0.0256 0.0256
Entamoeba histolytica protein kinase, putative 0.1782 1 1
Entamoeba histolytica protein kinase, putative 0.0081 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0068 0.0256 0.038
Loa Loa (eye worm) AGC/PKG protein kinase 0.005 0.0157 0.0157
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0588 0.3211 0.4769
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0256 0.0403
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0588 0.3211 0.3211
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.114 0.6349 1
Toxoplasma gondii hypothetical protein 0.0068 0.0256 0.0266
Entamoeba histolytica PH domain containing protein kinase, putative 0.1207 0.6733 0.6733
Entamoeba histolytica PH domain containing protein 0.0068 0.0256 0.0256
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0164 0.0803 0.0803
Echinococcus multilocularis beta 1 syntrophin 0.0068 0.0256 0.038
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0068 0.0256 0.038
Echinococcus multilocularis protein kinase c epsilon type 0.0588 0.3211 0.4769
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0068 0.0256 0.0256
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0164 0.0803 0.1192
Echinococcus granulosus DCC interacting protein 13 beta 0.0068 0.0256 0.038
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0068 0.0256 0.038
Leishmania major hypothetical protein, conserved 0.0068 0.0256 0.777
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0185 0.0185
Trichomonas vaginalis protein transport protein sec7, putative 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0044
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0329 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0044 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Brugia malayi Pleckstrin Homology Domain 0.0068 0.0256 0.0256
Echinococcus multilocularis actin binding protein anillin 0.0068 0.0256 0.038
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0068 0.0256 0.038
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Entamoeba histolytica hypothetical protein 0.0081 0.0329 0.0329
Echinococcus granulosus dynamin 1 0.0068 0.0256 0.038
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0068 0.0256 0.038
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Trypanosoma cruzi Protein kinase B 0.1207 0.6733 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0081 0.0329 0.0488
Echinococcus multilocularis Pleckstrin y 0.0068 0.0256 0.038
Mycobacterium tuberculosis Carboxylesterase LipT 0.0164 0.0803 1
Trichomonas vaginalis kinesin light chain, putative 0.0068 0.0256 0.0256
Brugia malayi Oxysterol-binding protein 0.0068 0.0256 0.0256
Schistosoma mansoni centaurin alpha 0.0068 0.0256 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis pdz domain containing protein 0.0068 0.0256 0.038
Brugia malayi Protein kinase domain containing protein 0.0588 0.3211 0.3211
Entamoeba histolytica PH domain containing protein kinase, putative 0.1207 0.6733 0.6733
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1127 0.6275 0.932
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis cytohesin 1 0.0068 0.0256 0.038
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Echinococcus multilocularis Pleckstrin y 0.0068 0.0256 0.038
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Entamoeba histolytica protein kinase, putative 0.1714 0.9615 0.9615
Schistosoma mansoni oxysterol-binding protein 1 0.0068 0.0256 0.038
Mycobacterium ulcerans hypothetical protein 0.0037 0.0084 0.1042
Leishmania major folate/biopterin transporter, putative 0.0081 0.0329 1
Echinococcus multilocularis acetylcholinesterase 0.097 0.5385 0.7998
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Brugia malayi MAX-1A 0.0068 0.0256 0.0256
Echinococcus granulosus pdz domain containing protein 0.0068 0.0256 0.038
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0068 0.0256 0.038
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0081 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0588 0.3211 0.3211
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Echinococcus granulosus nervana 2 0.1127 0.6275 0.932
Plasmodium falciparum calcium-dependent protein kinase 7 0.0081 0.0329 0.0518
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0068 0.0256 0.0256
Echinococcus multilocularis Pleckstrin y 0.0068 0.0256 0.038
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0157 0.0233
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0068 0.0256 0.0256
Brugia malayi Egg laying defective protein 4 0.005 0.0157 0.0157
Loa Loa (eye worm) syntrophin-1 0.0068 0.0256 0.0256
Echinococcus granulosus Rho GTPase activating protein 24 0.0068 0.0256 0.038
Schistosoma mansoni atypical protein kinase C 0.0588 0.3211 0.4769
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0068 0.0256 0.0403
Echinococcus multilocularis acetylcholinesterase 0.097 0.5385 0.7998
Echinococcus granulosus para nitrobenzyl esterase 0.0164 0.0803 0.1192
Schistosoma mansoni dynamin 0.0068 0.0256 0.038
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0044 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Schistosoma mansoni BC026374 protein (S09 family) 0.0164 0.0803 0.1192
Trichomonas vaginalis AGC family protein kinase 0.0655 0.3596 0.3596
Schistosoma mansoni acetylcholinesterase 0.0164 0.0803 0.1192
Brugia malayi hypothetical protein 0.0164 0.0803 0.0803
Echinococcus granulosus beta 1 syntrophin 0.0068 0.0256 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Trichomonas vaginalis centaurin/arf, putative 0.0068 0.0256 0.0256
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0081 0.0329 0.0488
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Echinococcus granulosus serine:threonine protein kinase N2 0.0588 0.3211 0.4769
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0081 0.0329 0.0488
Onchocerca volvulus 0.0164 0.0803 1
Echinococcus multilocularis myotubularin protein 13 0.0068 0.0256 0.038
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Schistosoma mansoni hypothetical protein 0.0068 0.0256 0.038
Schistosoma mansoni vav2 0.0068 0.0256 0.038
Loa Loa (eye worm) carboxylesterase 0.0164 0.0803 0.0803
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0164 0.0803 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0164 0.0803 0.1192
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1207 0.6733 1
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0588 0.3211 0.4769
Schistosoma mansoni syntrophin 0.0068 0.0256 0.038
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0329 0.0329
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0068 0.0256 0.0256
Echinococcus granulosus protein kinase c iota type 0.0588 0.3211 0.4769
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0068 0.0256 0.0256
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0068 0.0256 0.038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis serine:threonine protein kinase N2 0.0588 0.3211 0.4769
Loa Loa (eye worm) AGC/AKT protein kinase 0.1782 1 1
Echinococcus multilocularis carboxylesterase 5A 0.097 0.5385 0.7998
Echinococcus granulosus carboxylesterase 5A 0.097 0.5385 0.7998
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0068 0.0256 0.0256
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0081 0.0329 0.0488
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0044 0.0069
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Echinococcus granulosus acetylcholinesterase 0.097 0.5385 0.7998
Schistosoma mansoni rho gtpase activating protein 0.0068 0.0256 0.038
Plasmodium falciparum oxysterol-binding protein, putative 0.0068 0.0256 0.0403
Brugia malayi Protein kinase domain containing protein 0.0588 0.3211 0.3211
Entamoeba histolytica p21-activated kinase 0.0081 0.0329 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) acetylcholinesterase 1 0.097 0.5385 0.5385
Echinococcus granulosus protein kinase c epsilon type 0.0588 0.3211 0.4769
Brugia malayi hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.114 0.6349 0.9429
Trypanosoma brucei protein kinase, putative 0.0081 0.0329 0.0329
Echinococcus multilocularis rac serine:threonine kinase 0.1207 0.6733 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0068 0.0256 0.0256
Loa Loa (eye worm) AGC/PKN protein kinase 0.0588 0.3211 0.3211
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Trichomonas vaginalis AGC family protein kinase 0.0588 0.3211 0.3211
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0081 0.0329 0.0488
Brugia malayi Carboxylesterase family protein 0.0164 0.0803 0.0803
Trichomonas vaginalis AGC family protein kinase 0.0588 0.3211 0.3211
Plasmodium falciparum cGMP-dependent protein kinase 0.005 0.0157 0.0247
Echinococcus granulosus pleckstrin y domain containing family A 0.0068 0.0256 0.038
Echinococcus granulosus cytohesin 1 0.0068 0.0256 0.038
Echinococcus granulosus GRB2 associated binding protein 3 0.0068 0.0256 0.038
Echinococcus granulosus serine threonine protein kinase nrc 0.114 0.6349 0.9429
Echinococcus multilocularis GRB2 associated binding protein 3 0.0068 0.0256 0.038
Brugia malayi probable spectrin beta chain 0.0068 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Toxoplasma gondii protein kinase domain-containing protein 0.0081 0.0329 0.0342
Trypanosoma cruzi NIMA-related kinase, putative 0.0081 0.0329 0.0488
Echinococcus granulosus oxysterol binding protein 1 0.0068 0.0256 0.038
Entamoeba histolytica hypothetical protein 0.0068 0.0256 0.0256
Echinococcus multilocularis expressed conserved protein 0.005 0.0157 0.0233
Echinococcus granulosus calcium dependent secretion activator 1 0.0068 0.0256 0.038
Trichomonas vaginalis protein transport protein sec7, putative 0.0068 0.0256 0.0256
Trichomonas vaginalis centaurin beta, putative 0.0068 0.0256 0.0256
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1127 0.6275 0.932
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0081 0.0329 0.0488
Brugia malayi TBC domain containing protein 0.0068 0.0256 0.0256
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0044 0.0044
Echinococcus granulosus nervana 2 0.1127 0.6275 0.932
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0081 0.0329 0.0329
Trichomonas vaginalis AGC family protein kinase 0.1782 1 1
Leishmania major protein kinase, putative 0.0081 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Trypanosoma cruzi PH domain containing protein, putative 0.0068 0.0256 0.038
Leishmania major hypothetical protein, conserved 0.003 0.0044 0.1336
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Echinococcus multilocularis cGMP dependent protein kinase 1 0.005 0.0157 0.0233
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0068 0.0256 0.038
Echinococcus granulosus oxysterol binding protein 9 0.0068 0.0256 0.038
Brugia malayi Carboxylesterase family protein 0.0164 0.0803 0.0803
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0081 0.0329 0.0488
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0081 0.0329 0.0518
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0068 0.0256 0.0256
Brugia malayi Carboxylesterase family protein 0.097 0.5385 0.5385
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0081 0.0329 0.0329
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0068 0.0256 0.038
Toxoplasma gondii Oxysterol-binding protein 0.0068 0.0256 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0185 0.0275
Leishmania major serine/threonine-protein kinase a, putative 0.0081 0.0329 1
Trypanosoma cruzi PH domain containing protein, putative 0.0068 0.0256 0.038
Trypanosoma brucei rac serine-threonine kinase, putative 0.1782 1 1
Brugia malayi protein kinase C II. 0.0588 0.3211 0.3211
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0068 0.0256 0.038
Echinococcus multilocularis oxysterol binding protein 1 0.0068 0.0256 0.038
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0068 0.0256 0.038
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0068 0.0256 0.0256
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0068 0.0256 0.0403
Echinococcus multilocularis dynamin 1 0.0068 0.0256 0.038
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0588 0.3211 0.3211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0185 0.0275
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0068 0.0256 0.0256
Trichomonas vaginalis centaurin gamma, putative 0.0068 0.0256 0.0256
Echinococcus granulosus Protein kinase C brain isozyme 0.0588 0.3211 0.4769
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0068 0.0256 0.0256
Entamoeba histolytica hypothetical protein 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0588 0.3211 0.3211
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Trichomonas vaginalis alpha chimerin, putative 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0068 0.0256 0.0403
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.1714 0.9615 0.9615
Trypanosoma cruzi hypothetical protein 0.0068 0.0256 0.038
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0575 0.3138 0.3138
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0588 0.3211 0.3211
Loa Loa (eye worm) cytohesin 3 0.0068 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0256 0.0256
Entamoeba histolytica protein kinase 2, putative 0.114 0.6349 0.6349
Schistosoma mansoni serine/threonine protein kinase 0.0588 0.3211 0.4769
Schistosoma mansoni growth factor receptor-bound protein 0.0068 0.0256 0.038
Trypanosoma cruzi PH domain containing protein, putative 0.0068 0.0256 0.038
Trichomonas vaginalis centaurin alpha, putative 0.0068 0.0256 0.0256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0185 0.0275
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Echinococcus multilocularis BC026374 protein (S09 family) 0.0164 0.0803 0.1192
Echinococcus granulosus Glutaredoxin protein 5 0.1127 0.6275 0.932
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0068 0.0256 0.038
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0068 0.0256 0.0256
Echinococcus multilocularis serine:threonine protein kinase N2 0.0588 0.3211 0.4769
Trichomonas vaginalis hypothetical protein 0.0068 0.0256 0.0256
Brugia malayi Uncoordinated protein 104 0.0068 0.0256 0.0256
Echinococcus multilocularis Ras associated and pleckstrin y 0.0068 0.0256 0.038
Trichomonas vaginalis centaurin/arf, putative 0.0068 0.0256 0.0256
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0068 0.0256 0.0256
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0068 0.0256 0.038
Brugia malayi p70 ribosomal S6 kinase beta 0.1714 0.9615 0.9615
Onchocerca volvulus 0.0164 0.0803 1
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Brugia malayi Carboxylesterase family protein 0.097 0.5385 0.5385
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0068 0.0256 0.038
Echinococcus granulosus Pleckstrin y 0.0068 0.0256 0.038
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0068 0.0256 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0185 0.0275
Echinococcus multilocularis calcium dependent secretion activator 1 0.0068 0.0256 0.038
Echinococcus granulosus Pleckstrin y 0.0068 0.0256 0.038
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.097 0.5385 0.5385
Echinococcus multilocularis nervana 2 0.1127 0.6275 0.932
Entamoeba histolytica hypothetical protein 0.0081 0.0329 0.0329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0803 0.1192
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0164 0.0803 0.1192
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Brugia malayi PH domain containing protein 0.0068 0.0256 0.0256
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0068 0.0256 0.038
Brugia malayi Carboxylesterase family protein 0.0164 0.0803 0.0803
Loa Loa (eye worm) AGC/NDR protein kinase 0.0588 0.3211 0.3211
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0044 0.0065
Entamoeba histolytica protein kinase, putative 0.0081 0.0329 0.0329
Entamoeba histolytica protein kinase, putative 0.0081 0.0329 0.0329
Echinococcus multilocularis Oxysterol binding protein 11 0.0068 0.0256 0.038
Loa Loa (eye worm) carboxylesterase 0.0164 0.0803 0.0803
Brugia malayi Cadps2 protein 0.0068 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0256 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0081 0.0329 0.0329
Echinococcus granulosus protein kinase C gamma type 0.0588 0.3211 0.4769

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9935 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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