Detailed information for compound 1435569

Basic information

Technical information
  • TDR Targets ID: 1435569
  • Name: 1-[4-(3-bromothiophen-2-yl)-1,3-thiazol-2-yl] -3-(4-chlorophenyl)urea
  • MW: 414.728 | Formula: C14H9BrClN3OS2
  • H donors: 2 H acceptors: 2 LogP: 4.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1scc(n1)c1sccc1Br)Nc1ccc(cc1)Cl
  • InChi: 1S/C14H9BrClN3OS2/c15-10-5-6-21-12(10)11-7-22-14(18-11)19-13(20)17-9-3-1-8(16)2-4-9/h1-7H,(H2,17,18,19,20)
  • InChiKey: DLABTXPDYBHNCW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[4-(3-bromo-2-thienyl)thiazol-2-yl]-3-(4-chlorophenyl)urea
  • 1-[4-(3-bromo-2-thienyl)-2-thiazolyl]-3-(4-chlorophenyl)urea
  • N-[4-(3-bromo-2-thienyl)-1,3-thiazol-2-yl]-N'-(4-chlorophenyl)urea
  • SMR000170198
  • Oprea1_333672
  • 9J-906
  • MLS000326009

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin L-like precursor 0.0014 0.002 0.0016
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0367 0.0851 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.002 0.0016
Trypanosoma brucei glycerol uptake protein, putative 0.0367 0.0851 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.007 0.0066
Brugia malayi Cathepsin L-like precursor 0.002 0.0036 0.0032
Schistosoma mansoni cathepsin s 0.0007 0.0004 0.0004
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0016 0.0016
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0009 0.0008 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0032
Entamoeba histolytica hypothetical protein 0.0043 0.009 0.0927
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.4257 1 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0367 0.0851 0.0851
Leishmania major glycerol uptake protein, putative 0.0367 0.0851 1
Echinococcus multilocularis zinc finger protein 0.389 0.9137 0.9137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0169 0.1953
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0143 0.1595
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0154 0.1768
Schistosoma mansoni cytochrome P450 0.0009 0.0008 0.0008
Echinococcus granulosus lamin 0.0033 0.0065 0.0057
Leishmania major cathepsin L-like protease 0.0077 0.0169 0.1911
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0016 0.0089
Entamoeba histolytica hypothetical protein 0.0043 0.009 0.0927
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0009 0.0008 0.5
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0036 0.0275
Trichomonas vaginalis porcupine, putative 0.0367 0.0851 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0013 0.0052
Mycobacterium leprae putative cytochrome p450 0.0009 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0367 0.0851 0.0843
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0367 0.0851 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.0045 0.0036
Brugia malayi intermediate filament protein 0.0033 0.0065 0.0061
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0036 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0036 0.0344
Echinococcus multilocularis musashi 0.0033 0.0065 0.0057
Onchocerca volvulus Cathepsin F homolog 0.002 0.0036 0.0189
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0009 0.0008 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0007 0.00000000027488
Loa Loa (eye worm) CYP4Cod1 0.0009 0.0008 0.0004
Leishmania major glycerol uptake protein, putative 0.0367 0.0851 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0009 0.0008 0.5
Loa Loa (eye worm) cytochrome P450 0.0009 0.0008 0.0004
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0367 0.0851 0.0843
Echinococcus multilocularis cysteine protease 0.002 0.0036 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0009 0.0008 0.5
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0009 0.0008 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0367 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0016
Onchocerca volvulus 0.0035 0.007 0.0598
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0009 0.0008 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0045 0.0429
Onchocerca volvulus 0.002 0.0036 0.0189
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0008 0.0052
Entamoeba histolytica hypothetical protein 0.0367 0.0851 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Trypanosoma brucei glycerol uptake protein, putative 0.0367 0.0851 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0075 0.0066
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0367 0.0851 0.0851
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.009 0.009
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0045 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0009 0.0008 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0009 0.0008 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0007 0.00000000027488
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0025 0.0017
Entamoeba histolytica vacuolar protein sorting 26 0.0367 0.0851 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0045 0.0429
Brugia malayi Cytochrome P450 family protein 0.0009 0.0008 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0013 0.0104
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0367 0.0851 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0008 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.002 0.0158
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0367 0.0851 0.0851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0007 0.00000000027488
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.002
Echinococcus granulosus o acyltransferase membrane bound domain 0.0367 0.0851 0.0843
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0009 0.0008 0.0052
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0045 0.0448
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0367 0.0851 0.0843
Schistosoma mansoni lamin 0.0033 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0009 0.0008 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.009 0.009
Loa Loa (eye worm) ctsf protein 0.002 0.0036 0.0032
Echinococcus granulosus o acyltransferase membrane bound domain 0.0367 0.0851 0.0843
Schistosoma mansoni hypothetical protein 0.0367 0.0851 0.0851
Echinococcus multilocularis sterol O acyltransferase 1 0.0367 0.0851 0.0843
Schistosoma mansoni DNA helicase recq1 0.0024 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Loa Loa (eye worm) cysteine protease 0.002 0.0036 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0007 0.00000000027488
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0029 0.0025
Echinococcus multilocularis cysteine protease 0.002 0.0036 0.0027
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0016 0.014
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0016 0.0037
Schistosoma mansoni lamin 0.0033 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0367 0.0851 0.0847
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0009 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0036 0.0344
Trichomonas vaginalis transmembrane protein nessy, putative 0.0367 0.0851 1
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0008
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0367 0.0851 0.0843
Brugia malayi Cytochrome P450 family protein 0.0032 0.0063 0.0059
Echinococcus multilocularis cathepsin L 0.001 0.0013 0.0004
Brugia malayi Cathepsin L-like precursor 0.002 0.0036 0.0032
Plasmodium vivax vivapain-3 0.001 0.0013 0.0104
Plasmodium vivax vivapain-1 0.001 0.0013 0.0104
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0008 0.0004
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0013 0.0004
Schistosoma mansoni cpg binding protein 0.0037 0.0075 0.0075
Leishmania major cathepsin L-like protease 0.002 0.0036 0.0326
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0065 0.0061
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0009 0.0008 0.5
Trypanosoma cruzi glycerol uptake protein, putative 0.0367 0.0851 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0013 0.0013
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0009 0.0008 0.5
Echinococcus granulosus dnaJ subfamily B 0.0494 0.115 0.1142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0013
Onchocerca volvulus Cathepsin L homolog 0.002 0.0036 0.0189
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.4257 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0013 0.0104
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0041
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0017 0.0102
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0367 0.0851 0.0843
Echinococcus granulosus intermediate filament protein 0.0033 0.0065 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0017 0.005
Plasmodium vivax vivapain-2 0.002 0.0036 0.0376
Schistosoma mansoni DNA helicase recq5 0.0024 0.0045 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0065 0.0061
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.0061
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0045 0.0448
Onchocerca volvulus 0.0367 0.0851 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0045 0.0041
Loa Loa (eye worm) hhat protein 0.0367 0.0851 0.0847
Onchocerca volvulus 0.002 0.0036 0.0189
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0036 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0013 0.0071
Echinococcus granulosus cathepsin l1 0.002 0.0036 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0013 0.0052
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0036 0.0027
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.115 0.1142
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.007 0.0066
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0045 0.0479
Onchocerca volvulus 0.002 0.0036 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0045 0.0379
Onchocerca volvulus 0.0033 0.0065 0.0539
Loa Loa (eye worm) fibroinase 0.002 0.0036 0.0032
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0367 0.0851 0.0847
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0009 0.0008 0.5
Brugia malayi Hhat protein 0.0367 0.0851 0.0847
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0013 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1948 0.1948
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0045 0.0036
Brugia malayi Cytochrome P450 family protein 0.0009 0.0008 0.0004
Entamoeba histolytica hypothetical protein 0.0043 0.009 0.0927
Brugia malayi MBOAT family protein 0.0367 0.0851 0.0847
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0013 0.0009
Schistosoma mansoni sterol O-acyltransferase 1 0.0367 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0367 0.0851 0.0847
Schistosoma mansoni cpg binding protein 0.0037 0.0075 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Plasmodium vivax vivapain-2 0.002 0.0036 0.0376
Echinococcus granulosus o acyltransferase membrane bound domain 0.0367 0.0851 0.0843
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0036 0.0036
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0065 0.0061
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0367 0.0851 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Onchocerca volvulus 0.002 0.0036 0.0189
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0008 0.0004
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0009 0.0008 0.5
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0367 0.0851 0.0851
Schistosoma mansoni hypothetical protein 0.0494 0.115 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.002 0.0158
Echinococcus multilocularis lamin 0.0033 0.0065 0.0057
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0009 0.0008 0.5
Brugia malayi Cathepsin L-like precursor 0.0014 0.002 0.0016
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0013 0.0013
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0367 0.0851 0.0843
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0059
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0009 0.0008 0.5
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0009 0.0008 0.5
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0036 0.0275
Echinococcus granulosus cysteine protease 0.001 0.0013 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0013 0.0009
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0045 0.0036
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0367 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0016
Trypanosoma cruzi glycerol uptake protein, putative 0.0367 0.0851 1
Echinococcus granulosus lamin dm0 0.0033 0.0065 0.0057
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0036 0.0027
Leishmania major cathepsin L-like protease 0.002 0.0036 0.0326
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0036 0.0027
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0045 0.0041
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0009 0.0008 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0009 0.0008 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0009 0.0008 0.5
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0045 0.0379
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0367 0.0851 1
Onchocerca volvulus 0.0033 0.0065 0.0539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0045 0.0429
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0036 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0367 0.0851 0.0851
Echinococcus granulosus cathepsin l1 0.0014 0.002 0.0012
Onchocerca volvulus 0.002 0.0036 0.0189
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0045 0.0036
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0014 0.0005
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0367 0.0851 1
Echinococcus granulosus cpg binding protein 0.0037 0.0075 0.0066
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0367 0.0851 1
Brugia malayi cytochrome P450 0.0009 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0036 0.0032
Loa Loa (eye worm) MBOAT family protein 0.0367 0.0851 0.0847
Treponema pallidum alginate O-acetylation protein (algI) 0.0367 0.0851 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0045 0.0448
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0367 0.0851 0.0847
Leishmania major cathepsin L-like protease 0.002 0.0036 0.0326
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0045 0.0036
Echinococcus granulosus cathepsin L 0.001 0.0013 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0009 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0017 0.0153
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0367 0.0851 0.0843
Echinococcus multilocularis lamin dm0 0.0033 0.0065 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0036 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0367 0.0851 0.0847
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Loa Loa (eye worm) hypothetical protein 0.0367 0.0851 0.0847
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0009 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0013 0.0071
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0017 0.0153
Trypanosoma cruzi cysteine protease, putative 0.001 0.0013 0.0104
Brugia malayi Cathepsin L-like precursor 0.002 0.0036 0.0032
Loa Loa (eye worm) hhat protein 0.0367 0.0851 0.0847
Schistosoma mansoni zinc finger protein 0.4257 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.009 0.0082
Trypanosoma cruzi GUP1, putative 0.0367 0.0851 1
Leishmania major glycerol uptake protein, putative 0.0367 0.0851 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0007 0.00000000027488
Leishmania major cathepsin L-like protease 0.002 0.0036 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Brugia malayi Cathepsin L-like precursor 0.002 0.0036 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0009 0.0008 0.5
Brugia malayi MBOAT family protein 0.0367 0.0851 0.0847
Leishmania major cathepsin L-like protease 0.002 0.0036 0.0326
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0161 0.0161
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0009 0.0008 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0169 0.1953
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0036 0.0027
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0045 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0013
Echinococcus granulosus zinc finger protein 0.389 0.9137 0.9137
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0009 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0009 0.0008 0.5
Trypanosoma cruzi GUP1, putative 0.0367 0.0851 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0017 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0007 0.00000000027488
Trypanosoma cruzi glycerol uptake protein, putative 0.0367 0.0851 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0045 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0014 0.0005
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.002 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0169 0.1953
Leishmania major hypothetical protein, conserved 0.0367 0.0851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Entamoeba histolytica hypothetical protein 0.0043 0.009 0.0927
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0036 0.0376
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0008 0.0052
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0367 0.0851 0.0843
Loa Loa (eye worm) RecQ helicase 0.0024 0.0045 0.0041
Brugia malayi Cytochrome P450 family protein 0.0009 0.0008 0.0004
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0013 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0036 0.0344
Onchocerca volvulus Cathepsin L homolog 0.002 0.0036 0.0189
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.002 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0009 0.0008 0.5
Leishmania major glycerol uptake protein, putative 0.0367 0.0851 1
Toxoplasma gondii hypothetical protein 0.0367 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0036 0.0344
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0009 0.0008 0.5
Toxoplasma gondii cathepsin CPL 0.002 0.0036 0.0326
Schistosoma mansoni cpg binding protein 0.0035 0.007 0.007
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0009 0.0008 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0063 0.0059
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0036 0.0027
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0036 0.0027
Schistosoma mansoni intermediate filament proteins 0.0033 0.0065 0.0065
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0367 0.0851 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0014 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0008 0.0052
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0009 0.0008 0.5
Leishmania major cathepsin L-like protease 0.0077 0.0169 0.1911
Brugia malayi Cathepsin L-like precursor 0.002 0.0036 0.0032
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0025 0.0017
Brugia malayi Cathepsin L-like precursor 0.002 0.0036 0.0032
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0367 0.0851 0.0843
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0009 0.0008 0.5
Loa Loa (eye worm) MBOAT family protein 0.4257 1 1
Brugia malayi diacylglycerol acyltransferase 0.0367 0.0851 0.0847
Brugia malayi MBOAT family protein 0.0367 0.0851 0.0847
Onchocerca volvulus 0.002 0.0036 0.0189
Plasmodium vivax unspecified product 0.001 0.0013 0.0104
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0169 0.1953
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0045 0.0429
Leishmania major cathepsin L-like protease 0.0077 0.0169 0.1911
Loa Loa (eye worm) MBOAT family protein 0.0367 0.0851 0.0847
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0009 0.0008 0.5
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1948 0.1941
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0009 0.0008 0.5
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0367 0.0851 0.0843
Leishmania major cysteine peptidase A (CPA) 0.002 0.0036 0.0326
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1948 0.1941
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0045 0.0379
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0009 0.0008 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.002 0.002
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0367 0.0851 0.0843
Brugia malayi hypothetical protein 0.0043 0.009 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0009 0.0008 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0367 0.0851 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0013 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0169 0.1911
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0009 0.0008 0.5
Onchocerca volvulus 0.002 0.0036 0.0189
Entamoeba histolytica cysteine protease, putative 0.002 0.0036 0.0275
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0131 0.1495
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.009 0.0082
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0013 0.0104
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0009 0.0008 0.5
Leishmania major glycerol uptake protein, putative 0.0367 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0029 0.0025
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0009 0.0008 0.5
Brugia malayi MBOAT family protein 0.0367 0.0851 0.0847
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0036 0.0275
Echinococcus granulosus sterol O acyltransferase 1 0.0367 0.0851 0.0843
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0009 0.0008 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0007 0.00000000027488
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0009 0.0008 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0007 0.00000000027488
Trichomonas vaginalis conserved hypothetical protein 0.0367 0.0851 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.630957344 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 17.7827941 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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