Detailed information for compound 1447333

Basic information

Technical information
  • TDR Targets ID: 1447333
  • Name: 5-(4-bromophenyl)-N-[1-[(4-chlorophenyl)methy l]-5-methylpyrazol-3-yl]-1,2-oxazole-3-carbox amide
  • MW: 471.734 | Formula: C21H16BrClN4O2
  • H donors: 1 H acceptors: 3 LogP: 5.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cn1nc(cc1C)NC(=O)c1noc(c1)c1ccc(cc1)Br
  • InChi: 1S/C21H16BrClN4O2/c1-13-10-20(25-27(13)12-14-2-8-17(23)9-3-14)24-21(28)18-11-19(29-26-18)15-4-6-16(22)7-5-15/h2-11H,12H2,1H3,(H,24,25,28)
  • InChiKey: YIJNANNJJXGBSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-bromophenyl)-N-[1-[(4-chlorophenyl)methyl]-5-methyl-pyrazol-3-yl]isoxazole-3-carboxamide
  • 5-(4-bromophenyl)-N-[1-[(4-chlorophenyl)methyl]-5-methyl-3-pyrazolyl]-3-isoxazolecarboxamide
  • 5-(4-bromophenyl)-N-[1-(4-chlorobenzyl)-5-methyl-pyrazol-3-yl]isoxazole-3-carboxamide
  • 5-(4-bromophenyl)-N-[1-[(4-chlorophenyl)methyl]-5-methyl-pyrazol-3-yl]-1,2-oxazole-3-carboxamide
  • C226-0563
  • NCGC00105492-01
  • EU-0057118

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0155 0.1795 0.3146
Brugia malayi Trypsin family protein 0.0029 0.0224 0.0329
Giardia lamblia Kinase, CMGC CDK 0.0094 0.1033 0.8206
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.006 0.0608 0.5183
Giardia lamblia Kinase, PLK 0.0103 0.1143 0.912
Brugia malayi hypothetical protein 0.0016 0.0059 0.0033
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0158 0.1128
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0276 0.2186
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0158 0.3671
Entamoeba histolytica protein kinase, putative 0.0056 0.0561 0.4752
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1143 0.1114
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0597 0.4577
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.0561 0.1068
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0274 0.0241
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0095 0.1053 0.1023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0274 0.0447
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0044 0.0406 0.0755
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1208 0.2378
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0257
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0167 0.1953 0.3887
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0111 0.1249 0.2136
Plasmodium falciparum calcium-dependent protein kinase 4 0.004 0.0354 0.0568
Trypanosoma brucei glucose transporter 1E 0.0033 0.0276 0.2186
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0096 0.0063
Brugia malayi RhoGAP domain containing protein 0.0028 0.0207 0.0299
Schistosoma mansoni sugar transporter 0.0015 0.0047 0.0027
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0095 0.1053 0.2064
Schistosoma mansoni nuclear receptor 0.0016 0.0053 0.0041
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0262 0.0398
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0031 0.0246 0.1919
Echinococcus granulosus protein kinase C gamma type 0.0084 0.0915 0.1786
Brugia malayi P21-Rho-binding domain containing protein 0.0016 0.0052 0.0021
Schistosoma mansoni hypothetical protein 0.0029 0.0224 0.0386
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0158 0.0928
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0053 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0276 0.1906
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0597 0.1514
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0094 0.1033 0.901
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0276 0.1906
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0127 0.1445 0.2858
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0597 0.0566
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0597 0.1141
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0373 0.0596
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.006 0.0608 0.5183
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0158 0.0336
Onchocerca volvulus 0.0111 0.1248 0.63
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0094 0.0126
Echinococcus granulosus General substrate transporter 0.0093 0.1018 0.1994
Plasmodium falciparum calcium-dependent protein kinase 2 0.004 0.0354 0.0568
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0031
Echinococcus multilocularis serine threonine protein kinase 0.0084 0.0915 0.0885
Brugia malayi Sugar transporter family protein 0.0108 0.1208 0.2093
Schistosoma mansoni coup transcription factor 0.0033 0.0274 0.0487
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0274 0.119
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0053 0.002
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0037 0.0316 0.0522
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0047 0.0014
Onchocerca volvulus 0.0016 0.0053 0.0035
Brugia malayi RhoGAP domain containing protein 0.0028 0.0207 0.0299
Loa Loa (eye worm) AGC/NDR protein kinase 0.0044 0.0406 0.0685
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0274 0.0487
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0094 0.0126
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0262 0.0463
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.035 0.0318
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0096 0.0126
Entamoeba histolytica protein kinase, putative 0.0046 0.0437 0.3635
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0262 0.0398
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0053 0.002
Brugia malayi major facilitator superfamily protein 0.0015 0.0047 0.0011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0597 0.5079
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Schistosoma mansoni netrin receptor unc5 0.0018 0.0078 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Echinococcus granulosus nervana 2 0.002 0.0113 0.0162
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4973 0.4956
Brugia malayi Sugar transporter family protein 0.0015 0.0047 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0044 0.0406 0.0685
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0028 0.0207 0.0174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.012 0.0175
Onchocerca volvulus 0.0145 0.1674 0.8535
Echinococcus multilocularis protein kinase c iota type 0.0072 0.0756 0.0726
Echinococcus multilocularis Diacylglycerol kinase theta 0.0028 0.0207 0.0174
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0016 0.0052 0.0038
Schistosoma mansoni glucose transport protein 0.0108 0.1208 0.2378
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0406 0.0755
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0094 0.0162
Echinococcus multilocularis raf serine:threonine protein kinase 0.0033 0.0275 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0274 0.0241
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.003 0.0235 0.1567
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.004 0.0014
Echinococcus granulosus neuroglian 0.0027 0.0197 0.0331
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.1033 0.1805
Echinococcus granulosus aryl hydrocarbon receptor 0.0134 0.1534 0.3038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0276 0.1906
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0274 0.0418
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0247 0.193
Schistosoma mansoni unc-13 (munc13) 0.0029 0.0223 0.0383
Leishmania major glucose transporter, lmgt1 0.0033 0.0276 0.2186
Giardia lamblia Kinase, STE STE20 0.006 0.0608 0.4672
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.004 0.0354 0.0545
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0113 0.2669
Echinococcus granulosus NDR protein kinase 0.0044 0.0406 0.0755
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0597 0.5079
Loa Loa (eye worm) sugar transporter 0.0015 0.0047 0.0042
Echinococcus multilocularis transfer RNA-Lys 0.0046 0.0432 0.04
Schistosoma mansoni protein kinase 0.0046 0.043 0.0804
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.1783 0.3541
Schistosoma mansoni retinoic acid receptor RXR 0.0134 0.1533 0.3035
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0047 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Brugia malayi p70 ribosomal S6 kinase beta 0.0064 0.0663 0.1116
Brugia malayi Protein kinase domain containing protein 0.046 0.5619 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.1999 0.3512
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0158 0.1128
Toxoplasma gondii protein kinase, putative 0.0311 0.3757 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0274 0.0418
Onchocerca volvulus 0.0133 0.1527 0.7766
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0276 0.1906
Brugia malayi hypothetical protein 0.0037 0.0316 0.0494
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0276 0.1906
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0276 0.1906
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0276 0.2186
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0077 0.0096
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0094 0.0126
Plasmodium vivax calcium-dependent protein kinase, putative 0.004 0.0354 0.0545
Schistosoma mansoni unc-13 (munc13) 0.0029 0.0223 0.0383
Plasmodium falciparum protein kinase 7 0.0311 0.3757 0.6601
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.003 0.0235 0.0379
Loa Loa (eye worm) hypothetical protein 0.0016 0.0059 0.0063
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.004 0.0354 0.0545
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0329 0.0525
Echinococcus multilocularis myosin iiia 0.006 0.0608 0.0577
Echinococcus multilocularis rac serine:threonine kinase 0.0031 0.0247 0.0215
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0053 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Echinococcus granulosus cyclin dependent kinase 1 0.0094 0.1033 0.2024
Loa Loa (eye worm) trypsin family protein 0.0029 0.0224 0.0358
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0207 0.0299
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0047 0.5
Echinococcus granulosus myotubularin protein 13 0.003 0.0233 0.0404
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0031 0.0247 0.193
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0274 0.0487
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0019 0.01 0.0067
Trypanosoma brucei cdc2-related kinase 1 0.0094 0.1033 0.901
Brugia malayi Protein kinase c protein 2 0.0077 0.0824 0.1406
Echinococcus granulosus cyclin dependent kinase 5 0.0094 0.1033 0.2024
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0158 0.0198
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0216 0.0345
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0316 0.0573
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.004 0.0354 0.086
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Schistosoma mansoni nephrin 0.0027 0.0197 0.0331
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0047 0.1085
Brugia malayi intracellular kinase 0.0056 0.0561 0.0933
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0094 0.1033 0.2024
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0113 0.0162
Onchocerca volvulus 0.0033 0.0274 0.119
Entamoeba histolytica protein kinase, putative 0.0026 0.0186 0.1378
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0096 0.0063
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0597 0.0566
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0181 0.2123 0.5612
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0205
Brugia malayi Temporarily assigned gene name protein 59 0.0128 0.1462 0.2547
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Brugia malayi hypothetical protein 0.0016 0.0053 0.0023
Trypanosoma brucei cdc2-related kinase 3 0.0094 0.1033 0.901
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0235 0.0409
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0276 0.2186
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0406 0.0755
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.1033 0.901
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0245 0.0429
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0059 0.0098
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Echinococcus multilocularis protein kinase shaggy 0.0056 0.0561 0.0529
Loa Loa (eye worm) hypothetical protein 0.0138 0.1583 0.2788
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0274 0.0487
Onchocerca volvulus 0.0029 0.0223 0.0922
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0053 0.002
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0035 0.0298 0.2087
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1445 0.2858
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0648
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0053 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0016 0.0052 0.0038
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0047 0.0122
Brugia malayi cell division control protein 2 homolog 0.0094 0.1033 0.178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0274 0.0487
Loa Loa (eye worm) hypothetical protein 0.0118 0.1332 0.2339
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0047 0.0036
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0022 0.0127 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Schistosoma mansoni protein kinase 0.0168 0.1967 0.3915
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Schistosoma mansoni glucose transport protein 0.0108 0.1208 0.2378
Echinococcus granulosus roundabout 2 0.003 0.0235 0.0408
Toxoplasma gondii sugar transporter ST1 0.0015 0.0047 0.0036
Trypanosoma brucei protein kinase, putative 0.0059 0.0597 0.5079
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1143 1
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.255
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0053 0.0035
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0112 0.1265 0.1236
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0432 0.3204
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.0561 0.0935
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0406 0.2991
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0274 0.0487
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Onchocerca volvulus 0.0019 0.0094 0.0245
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0016 0.0059 0.37
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0321
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0053 0.0054
Echinococcus granulosus Diacylglycerol kinase theta 0.0028 0.0207 0.0352
Onchocerca volvulus 0.0019 0.0094 0.0245
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0561 0.4275
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0158 0.3671
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0274 0.0418
Loa Loa (eye worm) AGC/PKN protein kinase 0.0044 0.0406 0.0685
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0597 0.4577
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0274 0.0418
Brugia malayi CXXC zinc finger family protein 0.0029 0.0216 0.0315
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0274 0.0418
Echinococcus multilocularis protein kinase c eta type 0.0028 0.0207 0.0174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.0081 0.0872 0.1517
Plasmodium falciparum calcium-dependent protein kinase 5 0.004 0.0354 0.0568
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.003 0.0235 0.0349
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0561 0.0961
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0044 0.0406 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0274 0.0418
Onchocerca volvulus 0.0046 0.0438 0.2053
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0222 0.1699
Echinococcus multilocularis transmembrane protease serine 3 0.0029 0.0224 0.0191
Echinococcus granulosus GPCR family 2 0.0019 0.0096 0.0126
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0096 0.0099
Echinococcus granulosus serine:threonine protein kinase N2 0.0044 0.0406 0.0755
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0025 0.0167 0.0134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.0207 0.0352
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0059 0.0228
Echinococcus granulosus enteropeptidase 0.0029 0.0224 0.0386
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0274 0.0418
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Plasmodium falciparum hexose transporter 0.0108 0.1208 0.2082
Schistosoma mansoni sugar transporter 0.0015 0.0047 0.0027
Brugia malayi ecdysteroid receptor 0.0033 0.0274 0.0418
Onchocerca volvulus 0.0029 0.0224 0.0928
Schistosoma mansoni protein kinase 0.0019 0.01 0.0135
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0028 0.0207 0.0328
Brugia malayi steroid hormone receptor 0.0033 0.0274 0.0418
Echinococcus granulosus solute carrier family 22 0.0015 0.0047 0.0027
Brugia malayi hypothetical protein 0.0029 0.0224 0.0329
Echinococcus multilocularis cyclin dependent kinase 0.0094 0.1033 0.1003
Entamoeba histolytica protein kinase, putative 0.0046 0.0437 0.3635
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Schistosoma mansoni protein kinase 0.0019 0.01 0.0135
Schistosoma mansoni ste20-related kinase 0.0179 0.2107 0.4198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0322 0.0533
Entamoeba histolytica protein kinase, putative 0.0024 0.016 0.1146
Plasmodium falciparum protein kinase 6 0.0464 0.5675 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0047 0.1085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0274 0.0447
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0113 1
Trypanosoma cruzi hexose transporter 0.0033 0.0276 0.2186
Onchocerca volvulus 0.0029 0.0224 0.0928
Entamoeba histolytica protein kinase, putative 0.004 0.0353 0.2884
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1208 0.1179
Brugia malayi Trypsin family protein 0.0029 0.0224 0.0329
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0047 0.0014
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0597 0.5079
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.004 0.0007
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0047 0.0027
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0059 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0406 0.0755
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0047 0.0042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0274 0.0487
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Echinococcus granulosus N chimaerin 0.0028 0.0207 0.0352
Brugia malayi Pleckstrin Homology Domain 0.003 0.0233 0.0345
Loa Loa (eye worm) hypothetical protein 0.005 0.0488 0.0831
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0597 0.4577
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0274 0.0241
Brugia malayi Protein kinase domain containing protein 0.0066 0.0688 0.1162
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0047 0.0011
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0113 0.0162
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0561 0.0961
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Schistosoma mansoni aryl hydrocarbon receptor 0.018 0.2109 0.4202
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0094 0.0162
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0262 0.1792
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0096
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0597 0.4577
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0648
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0053 0.0041
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.1208 0.1179
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0053 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.1953 0.3887
Brugia malayi C1-like domain containing protein 0.0118 0.1331 0.2313
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0113 0.008
Echinococcus multilocularis aryl hydrocarbon receptor 0.0134 0.1534 0.1506
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0619 0.1185
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.0561 0.4752
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0017 0.0065 0.0075
Echinococcus multilocularis unc 13 (munc13) 0.0029 0.0223 0.019
Leishmania major hypothetical protein, conserved 0.0015 0.0047 0.0122
Echinococcus multilocularis serine:threonine protein kinase 3 0.0231 0.275 0.2726
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0117 0.1326 0.2304
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.1033 0.1003
Trypanosoma brucei sugar transporter, putative 0.0015 0.0047 0.0122
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0167 0.1953 0.3429
Leishmania major protein kinase, putative 0.006 0.0608 0.5183
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0274 0.0241
Brugia malayi protein kinase C II. 0.0073 0.0772 0.1312
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1053 0.2064
Echinococcus granulosus death domain containing protein 0.0015 0.004 0.0014
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0406 0.0374
Echinococcus granulosus PAK box P21 Rho binding 0.0016 0.0052 0.0038
Schistosoma mansoni kinase 0.0056 0.0562 0.107
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0029 0.0222 0.0189
Plasmodium vivax CDK-related protein kinase 6, putative 0.0464 0.5675 1
Echinococcus granulosus transmembrane protease serine 3 0.0029 0.0224 0.0386
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Brugia malayi Sugar transporter family protein 0.0015 0.0047 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0274 0.0418
Brugia malayi hypothetical protein 0.0015 0.0047 0.0011
Echinococcus multilocularis nervana 2 0.002 0.0113 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0597 0.5079
Brugia malayi STE20-like kinase MST 0.0231 0.275 0.4858
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0246 0.0431
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0094 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0059 0.0098
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.0561 0.1068
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0158 0.0928
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0031 0.0246 0.1919
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0053 0.002
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0019 0.01 0.0067
Brugia malayi major facilitator superfamily protein 0.0015 0.0047 0.0011
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1143 0.2247
Brugia malayi tailless protein 0.0016 0.0053 0.0023
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0016 0.0052 0.0019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0406 0.2991
Echinococcus granulosus defective proboscis extension response 0.0025 0.0167 0.0271
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0016 0.0052 0.0038
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0247 0.0434
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Echinococcus multilocularis Immunoglobulin 0.0025 0.0167 0.0134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Brugia malayi putative serine/threonine kinase SADA gamma 0.0031 0.0246 0.0369
Echinococcus granulosus serine:threonine kinase SAD 1 0.0031 0.0246 0.0431
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0046 0.0436 0.0816
Brugia malayi hypothetical protein 0.0018 0.0077 0.0066
Schistosoma mansoni glucose transporter 0.0015 0.0047 0.0027
Echinococcus granulosus netrin receptor unc 5 0.0018 0.0078 0.0091
Schistosoma mansoni hypothetical protein 0.0037 0.0316 0.0573
Onchocerca volvulus 0.005 0.0488 0.2316
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0329 0.0795
Brugia malayi diacylglycerol kinase 0.0028 0.0207 0.0299
Brugia malayi hypothetical protein 0.0022 0.0138 0.0174
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0053 0.0023
Giardia lamblia Kinase, NEK 0.0111 0.1249 1
Trichomonas vaginalis AGC family protein kinase 0.0111 0.1249 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0274 0.0418
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0245 0.0212
Schistosoma mansoni nuclear receptor 0.0016 0.0053 0.0041
Echinococcus granulosus Mastin 0.0029 0.0224 0.0386
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0029 0.0223 0.0383
Brugia malayi conserved hypotetical protein 0.0016 0.0053 0.0023
Loa Loa (eye worm) hypothetical protein 0.0133 0.1527 0.2688
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0322 0.2286
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0053 0.0041
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Loa Loa (eye worm) hypothetical protein 0.0026 0.0186 0.0291
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0096 0.0129
Schistosoma mansoni vav2 0.003 0.0233 0.0404
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4973 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.046 0.5619 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0171 0.1999 0.3531
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0274 0.0241
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0025 0.0167 0.0271
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0086 0.0474
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0274 0.0418
Brugia malayi diacylglycerol kinase 0.0028 0.0207 0.0299
Onchocerca volvulus 0.0138 0.1583 0.8059
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.004 0.0353 0.0648
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1143 1
Echinococcus granulosus unc 13 munc13 0.0029 0.0223 0.0383
Onchocerca volvulus 0.0138 0.1583 0.8059
Plasmodium vivax hexose transporter 0.0108 0.1208 0.2063
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0127 0.1445 0.2518
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0188 0.2212 0.3912
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0046 0.0437 0.0817
Echinococcus multilocularis roundabout 2 0.003 0.0235 0.0202
Schistosoma mansoni protein kinase C mu 0.0028 0.0207 0.0352
Schistosoma mansoni protein kinase 0.004 0.0353 0.0648
Brugia malayi Cam kinase protein 1 0.004 0.0353 0.0561
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0274 0.0487
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0031 0.0246 0.0354
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0059 0.0098
Onchocerca volvulus 0.0029 0.0224 0.0928
Brugia malayi PAS domain containing protein 0.0062 0.0633 0.1063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0205
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0053 0.0041
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0231 0.275 0.4873
Leishmania major protein kinase, putative 0.0025 0.0167 0.1207
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0127 0.1445 0.1417
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0094 0.0126
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0181 0.2123 0.3689
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0077 0.0066
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0276 0.2186
Onchocerca volvulus 0.0019 0.0094 0.0245
Echinococcus granulosus cpg binding protein 0.003 0.0237 0.0411
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0053 0.0054
Echinococcus multilocularis rho associated protein kinase 0.0154 0.1783 0.1755
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0121 0.0619
Giardia lamblia Kinase, AGC PKA 0.0029 0.0222 0.1456
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Schistosoma mansoni cpg binding protein 0.003 0.0237 0.0411
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.1033 0.901
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0167 0.1207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0274 0.0418
Giardia lamblia Kinase, NEK 0.0111 0.1249 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0047 0.0024
Onchocerca volvulus 0.0019 0.0094 0.0245
Toxoplasma gondii PAN domain-containing protein 0.0293 0.3536 0.9404
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.1265 0.2494
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0046 0.043 0.0398
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1143 0.2247
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0406 0.2991
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0167 0.1953 0.3449
Echinococcus granulosus Protein kinase C brain isozyme 0.0112 0.1265 0.2494
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0158 0.0212
Plasmodium falciparum NIMA related kinase 1 0.0111 0.1249 0.2155
Brugia malayi Protein kinase domain containing protein 0.0094 0.1033 0.178
Loa Loa (eye worm) hypothetical protein 0.0085 0.0925 0.1611
Echinococcus multilocularis nervana 2 0.002 0.0113 0.008
Entamoeba histolytica hypothetical protein 0.0016 0.0052 0.0168
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.1033 0.901
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0797 0.0767
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0046 0.0436 0.0405
Echinococcus multilocularis solute carrier family 22 0.0015 0.0047 0.0014
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0029 0.0223 0.019
Brugia malayi MAP kinase sur-1 0.0059 0.0597 0.0998
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0059 0.0098
Schistosoma mansoni sugar transporter 0.0015 0.0047 0.0027
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1208 0.1179
Entamoeba histolytica protein kinase, putative 0.0044 0.0406 0.3362
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0024 0.016 0.0245
Echinococcus multilocularis N chimaerin 0.0028 0.0207 0.0174
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Brugia malayi Trypsin family protein 0.0029 0.0224 0.0329
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0158 0.0253
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0029 0.0224 0.0329
Onchocerca volvulus 0.0029 0.0224 0.0928
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0276 0.2186
Brugia malayi serine/threonine-protein kinase PAK 7 0.0024 0.016 0.0215
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0597 0.5079
Onchocerca volvulus 0.0019 0.0094 0.0245
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0328
Brugia malayi hypothetical protein 0.0015 0.0047 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0275 0.0489
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0116 0.1312 0.1283
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Echinococcus granulosus solute carrier family 22 0.0015 0.0047 0.0027
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0029 0.0224 0.0191
Brugia malayi WH1 domain containing protein 0.0016 0.0052 0.0021
Toxoplasma gondii PAN domain-containing protein 0.0293 0.3536 0.9404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Toxoplasma gondii subtilisin SUB12 0.0019 0.0094 0.0162
Echinococcus granulosus serine/threonine protein kinase 0.0031 0.0247 0.0434
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.1033 0.1805
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0053 0.0023
Onchocerca volvulus 0.0019 0.0094 0.0245
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.1033 0.901
Loa Loa (eye worm) hypothetical protein 0.0138 0.1583 0.2788
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0134 0.1533 0.3035
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0044 0.0406 0.0755
Echinococcus multilocularis GPCR, family 2 0.0019 0.0096 0.0063
Entamoeba histolytica hypothetical protein 0.0016 0.0052 0.0168
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0329 0.0502
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0276 0.2186
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0053 0.0041
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0059 0.0098
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1143 0.2001
Giardia lamblia Kinase, CAMK CAMKL 0.0031 0.0246 0.1659
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0316 0.0284
Loa Loa (eye worm) hypothetical protein 0.0067 0.07 0.121
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0029 0.0224 0.0386
Brugia malayi nuclear receptor NHR-88 0.0016 0.0053 0.0023
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.006 0.0608 0.5183
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0029 0.0222 0.0311
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0031 0.0246 0.0399
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0047 0.1085
Schistosoma mansoni hypothetical protein 0.0108 0.1208 0.2378
Loa Loa (eye worm) hypothetical protein 0.0032 0.0262 0.0427
Echinococcus multilocularis enteropeptidase 0.0029 0.0224 0.0191
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0167 0.1207
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Loa Loa (eye worm) hypothetical protein 0.0032 0.0262 0.0427
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.004 0.0354 0.086
Mycobacterium ulcerans sugar transporter 0.0015 0.0047 0.1085
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Entamoeba histolytica protein kinase, putative 0.0066 0.0688 0.5903
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Onchocerca volvulus 0.0019 0.0094 0.0245
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0059 0.0228
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0046 0.043 0.0804
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0053 0.0023
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0019 0.01 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Echinococcus multilocularis Mastin 0.0029 0.0224 0.0191
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.0561 0.0529
Mycobacterium ulcerans putative regulatory protein 0.0046 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0257
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0276 0.2186
Brugia malayi Protein kinase domain containing protein 0.0023 0.0149 0.0195
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0274 0.0447
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0447
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0597 0.1025
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.0207 0.0352
Schistosoma mansoni cpg binding protein 0.0029 0.0216 0.037
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0188 0.2212 0.4411
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0274 0.0487
Echinococcus multilocularis protein kinase c epsilon type 0.0073 0.0772 0.0741
Onchocerca volvulus 0.0029 0.0224 0.0928
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0113 0.008
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0207 0.1565
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0316 0.0573
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0191
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0797 0.1547
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0073 0.0772 0.1338
Brugia malayi Trypsin family protein 0.0029 0.0224 0.0329
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0047 0.0122
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0077 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.2212 0.4411
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0274 0.0418
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0127 0.1445 0.2541
Echinococcus multilocularis solute carrier family 22 0.0015 0.0047 0.0014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Schistosoma mansoni cell adhesion molecule 0.0028 0.0205 0.0348
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0033
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0207 0.1565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0096
Echinococcus granulosus protein kinase c iota type 0.0072 0.0756 0.1464
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Trichomonas vaginalis STE family protein kinase 0.0111 0.1249 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0274 0.0418
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.0207 0.0352
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.004 0.0354 0.086
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0047 0.0122
Echinococcus granulosus single minded 2 0.0046 0.0432 0.0806
Echinococcus multilocularis General substrate transporter 0.0093 0.1018 0.0988
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0247 0.193
Echinococcus granulosus Rac GTPase activating protein 1 0.0028 0.0207 0.0352
Loa Loa (eye worm) hypothetical protein 0.0138 0.1583 0.2788
Trypanosoma brucei polo-like protein kinase 0.0103 0.1143 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0167 0.0227
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0065 0.0032
Plasmodium falciparum protein kinase 5 0.0094 0.1033 0.1773
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0029 0.0224 0.0386
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0274 0.0487
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0246 0.0431
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1143 0.575
Toxoplasma gondii sugar transporter ST2 0.0015 0.0047 0.0036
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0028 0.0207 0.0328
Echinococcus granulosus protein kinase c eta type 0.0028 0.0207 0.0352
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0028 0.0205 0.0348
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0274 0.0447
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0262 1
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0042 0.0018
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0031 0.0246 0.0214
Loa Loa (eye worm) hypothetical protein 0.0109 0.1222 0.2143
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0096
Giardia lamblia Kinase, NEK 0.0111 0.1249 1
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0546 0.4156
Schistosoma mansoni protein kinase 0.0168 0.1967 0.3915
Loa Loa (eye worm) DR-78 0.0016 0.0053 0.0054
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0224 0.0386
Entamoeba histolytica p21-activated kinase 0.0048 0.0456 0.3808
Schistosoma mansoni protein kinase 0.0024 0.016 0.0258
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0262 0.1792
Entamoeba histolytica hypothetical protein 0.0024 0.0158 0.1128
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0094 0.1033 0.2685
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0274 0.0241
Toxoplasma gondii microneme protein MIC4 0.0019 0.0094 0.0162
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0044 0.0406 0.0374
Onchocerca volvulus 0.0109 0.1222 0.6165
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0688 0.1189
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0328
Brugia malayi nuclear receptor RXR 0.0016 0.0053 0.0023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0274 0.0487
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0044 0.0406 0.0374
Leishmania major glucose transporter, lmgt3 0.0033 0.0276 0.2186
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0274 0.0487
Loa Loa (eye worm) hypothetical protein 0.0041 0.0373 0.0625
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1053 0.2064
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0167 0.1207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0328
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0046 0.043 0.0398
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0262 0.023
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0274 0.0418
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Onchocerca volvulus Netrin receptor homolog 0.0017 0.007 0.0122
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0059 0.0098
Brugia malayi bHLH-PAS transcription factor 0.0046 0.0432 0.0701
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0257
Schistosoma mansoni protein kinase 0.0016 0.0052 0.0038
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.0561 0.4752
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Brugia malayi map kinase activated protein kinase protein 2 0.0188 0.2212 0.3893
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0047 0.0122
Brugia malayi Trypsin-like protease protein 5 0.0029 0.0224 0.0329
Onchocerca volvulus 0.0019 0.0094 0.0245
Schistosoma mansoni protein kinase C 0.0029 0.0223 0.0383
Toxoplasma gondii AGC kinase 0.0064 0.0663 0.169
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0016 0.0052 0.0051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1208 0.2378
Entamoeba histolytica protein kinase, putative 0.0064 0.0663 0.5672
Onchocerca volvulus 0.0019 0.0094 0.0245
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Leishmania major protein kinase, putative 0.004 0.0353 0.2884
Echinococcus granulosus protein kinase shaggy 0.0056 0.0561 0.1068
Schistosoma mansoni serine/threonine kinase 0.0044 0.0406 0.0755
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0094 0.0162
Brugia malayi Protein kinase domain containing protein 0.0167 0.1953 0.3429
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0094 0.0162
Echinococcus granulosus solute carrier family 22 0.0015 0.0047 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Brugia malayi Protein kinase domain containing protein 0.0044 0.0406 0.0656
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Echinococcus multilocularis Rac GTPase activating protein 1 0.0028 0.0207 0.0174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Brugia malayi hypothetical protein 0.0018 0.0077 0.0066
Loa Loa (eye worm) hypothetical protein 0.0117 0.1326 0.2327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0537 0.1354
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0053 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.0242
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0078 0.0068
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.004 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0274 0.0487
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0167 0.1953 0.1926
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1033 0.2024
Echinococcus multilocularis PAK box P21 Rho binding 0.0016 0.0052 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0096
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0224 0.0191
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.006 0.0608 0.5183
Onchocerca volvulus 0.0056 0.0561 0.2696
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0561 0.4275
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Echinococcus multilocularis neuroglian 0.0027 0.0197 0.0164
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0096 0.0126
Schistosoma mansoni hypothetical protein 0.0028 0.0207 0.0352
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0328
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0488 0.0921
Mycobacterium ulcerans hypothetical protein 0.0029 0.0224 0.5184
Echinococcus granulosus twitchin 0.0036 0.0305 0.0551
Onchocerca volvulus Tyrosine kinase homolog 0.0145 0.1681 0.8571
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0168 0.1967 0.3915
Entamoeba histolytica protein kinase, putative 0.0026 0.0186 0.1378
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0274 0.0447
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0046 0.0437 0.0405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Giardia lamblia Kinase, STE STE20 0.0046 0.043 0.319
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0597 0.1141
Echinococcus multilocularis netrin receptor unc 5 0.0018 0.0078 0.0045
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.003 0.0235 0.1819
Onchocerca volvulus 0.0154 0.1783 0.9105
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0262 0.0463
Trichomonas vaginalis STE family protein kinase 0.0024 0.016 0.0946
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.003 0.0235 0.0379
Trichomonas vaginalis STE family protein kinase 0.0046 0.043 0.319
Brugia malayi nuclear hormone receptor 0.0033 0.0274 0.0418
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1033 0.8206
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0274 0.0487
Schistosoma mansoni atypical protein kinase C 0.0072 0.0756 0.1464
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0059 0.0098
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0274 0.0487
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.004 0.0353 0.0561
Trypanosoma brucei protein kinase, putative 0.0056 0.0561 0.4752
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.2053 0.4088
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0053 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0274 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1033 0.8206
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0158 0.0253
Brugia malayi Fibronectin type III domain containing protein 0.0025 0.0167 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1033 0.8206
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.0688 0.5903
Loa Loa (eye worm) hypothetical protein 0.003 0.0235 0.0378
Echinococcus multilocularis cpg binding protein 0.003 0.0237 0.0204
Entamoeba histolytica protein kinase, putative 0.0041 0.0369 0.3026
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1143 1
Leishmania major glucose transporter, lmgt2 0.0033 0.0276 0.2186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0064 0.0663 0.1143
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0597 0.4577
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.255
Loa Loa (eye worm) hypothetical protein 0.0029 0.0224 0.0358
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.255
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.255
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0648
Leishmania major protein kinase, putative 0.0025 0.0167 0.1207
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0038
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.1208 0.3155
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0053 0.0023
Onchocerca volvulus 0.0019 0.0094 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0158 0.1128
Schistosoma mansoni hypothetical protein 0.0041 0.0373 0.0687
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0274 0.0487
Echinococcus granulosus cyclin dependent kinase 0.0094 0.1033 0.2024
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0094 0.0162
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0028 0.0205 0.0325
Schistosoma mansoni sugar transporter 0.0015 0.0047 0.0027
Trypanosoma cruzi p21-activated kinase 3, putative 0.003 0.0235 0.1819
Loa Loa (eye worm) hypothetical protein 0.0118 0.1337 0.2347
Echinococcus granulosus protein kinase c epsilon type 0.0073 0.0772 0.1496
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0053 0.0041
Loa Loa (eye worm) hypothetical protein 0.0166 0.1933 0.3413
Onchocerca volvulus 0.0019 0.0094 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.0561 0.1416
Brugia malayi Protein kinase domain 0.0046 0.043 0.0699
Brugia malayi ecdysone receptor 0.0016 0.0053 0.0023
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0047 0.0122
Toxoplasma gondii microneme protein, putative 0.0019 0.0094 0.0162
Loa Loa (eye worm) hypothetical protein 0.0182 0.2133 0.377
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.1033 0.901
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0047 0.0027
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0329 0.2668
Echinococcus multilocularis Immunoglobulin 0.0025 0.0167 0.0134
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0329 0.2668
Brugia malayi Protein kinase domain containing protein 0.0019 0.01 0.0107
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0094 0.0126
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0077 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0612 0.1024
Echinococcus multilocularis solute carrier family 22 0.0015 0.0047 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0054
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0059 0.0098
Echinococcus granulosus tumor protein p63 0.0344 0.4172 0.8378
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.006 0.0608 0.5183
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0094 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Brugia malayi hypothetical protein 0.0025 0.0167 0.0227
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0356
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0044 0.0406 0.0755
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0094 0.1033 0.1805
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0276 0.1906
Loa Loa (eye worm) hypothetical protein 0.0081 0.0872 0.1517
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0246 0.0431
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0094 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1033 0.2024
Brugia malayi Protein kinase domain containing protein 0.0044 0.0406 0.0656
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0047 0.0011
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0028 0.0207 0.0328
Trypanosoma brucei glucose transporter 2A 0.0033 0.0276 0.2186
Loa Loa (eye worm) hypothetical protein 0.0111 0.1248 0.2189
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0111 0.1249 0.3264
Brugia malayi nuclear receptor RXR 0.0018 0.0077 0.0066
Echinococcus multilocularis tumor protein p63 0.0344 0.4172 0.4152
Echinococcus multilocularis myotubularin protein 13 0.003 0.0233 0.02
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0077 0.0089
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1143 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0028 0.0207 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0235 0.0409
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0597 0.1141
Trichomonas vaginalis STE family protein kinase 0.0046 0.043 0.319
Brugia malayi probable protein kinase 0.0019 0.01 0.0107
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0046 0.043 0.0804
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0168 0.1967 0.1941
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1208 0.2378
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0329 0.2668
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0049 0.0474 0.0806
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.004 0.0353 0.059
Echinococcus granulosus rho-associated protein kinase 1 0.0154 0.1783 0.3541
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0118 0.1331 0.2313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0274 0.0418
Brugia malayi RhoGEF domain containing protein 0.0028 0.0207 0.0299
Onchocerca volvulus 0.0029 0.0216 0.0888
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0019 0.01 0.0135
Onchocerca volvulus 0.0081 0.0872 0.4329
Trichomonas vaginalis STE family protein kinase 0.006 0.0608 0.4672
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0353 0.0648
Brugia malayi nuclear receptor NHR-88 0.0033 0.0274 0.0418
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.0207 0.0352
Trichomonas vaginalis STE family protein kinase 0.0046 0.043 0.319
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0561 0.4275
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.022 0.2614 0.463
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1208 0.966
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0167 0.1953 1
Echinococcus granulosus serine:threonine protein kinase 3 0.0231 0.275 0.55
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0025 0.0167 0.0271
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.0399
Schistosoma mansoni glucose transport protein 0.0108 0.1208 0.2378
Plasmodium falciparum calcium-dependent protein kinase 3 0.004 0.0354 0.0568
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.004 0.0353 0.059
Entamoeba histolytica protein kinase, putative 0.0046 0.043 0.3577
Brugia malayi Ras association domain family 1 isoform A 0.0028 0.0207 0.0299
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0053 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0246 0.1659
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0031 0.0246 0.1919
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0612 0.1052
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0019 0.01 0.0135
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0053 0.0054
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0029 0.0222 0.0334
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0688 0.5337
Loa Loa (eye worm) hypothetical protein 0.003 0.0233 0.0374
Brugia malayi P21-Rho-binding domain containing protein 0.0016 0.0052 0.0021
Toxoplasma gondii hypothetical protein 0.0019 0.0094 0.0162
Brugia malayi hypothetical protein 0.0016 0.0053 0.0023
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0329 0.2668
Schistosoma mansoni protein kinase 0.0046 0.043 0.0804
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0167 0.1207
Schistosoma mansoni protein kinase 0.004 0.0353 0.0648
Plasmodium falciparum calcium-dependent protein kinase 1 0.004 0.0354 0.0568
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Brugia malayi PAN domain containing protein 0.0019 0.0094 0.0095
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1208 0.1179
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0175 0.2053 0.3627
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0167 0.1953 0.3449
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0044 0.0406 0.0685
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0274 0.0241
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0612 0.1024
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0274 0.0241
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.035 0.0641
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0328
Brugia malayi protein kinase C3,putative 0.0037 0.0316 0.0493
Onchocerca volvulus 0.0016 0.0053 0.0035
Toxoplasma gondii hypothetical protein 0.0019 0.0094 0.0162
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0031 0.0246 0.1919
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0126
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0053 0.0041
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.006 0.0612 0.1052
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0077 0.0066
Toxoplasma gondii sugar transporter ST3 0.0015 0.0047 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0274 0.0447
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0274 0.0487
Onchocerca volvulus 0.0029 0.0224 0.0928
Brugia malayi nuclear hormone receptor 0.0016 0.0053 0.0023
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0406 0.0374
Echinococcus multilocularis PAK box P21 Rho binding 0.0024 0.016 0.0128
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0274 0.0418
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0329 0.2668
Schistosoma mansoni protein kinase 0.004 0.0353 0.0648
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0274 0.119
Trichomonas vaginalis STE family protein kinase 0.0046 0.043 0.319
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Loa Loa (eye worm) sugar transporter 0.0108 0.1208 0.2117
Plasmodium falciparum mitogen-activated protein kinase 2 0.0181 0.2123 0.3704
Loa Loa (eye worm) CAMK/PKD protein kinase 0.009 0.0981 0.1711
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0053 0.0041
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0224 0.0386
Brugia malayi Hr1 repeat family protein 0.0044 0.0406 0.0656
Loa Loa (eye worm) hypothetical protein 0.003 0.0235 0.0378
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0096
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0113 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0096 0.0099
Echinococcus granulosus Immunoglobulin 0.0025 0.0167 0.0271
Plasmodium falciparum serine/threonine protein kinase KIN 0.0031 0.0246 0.0378
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0274 0.119
Giardia lamblia Kinase, CAMK CAMKL 0.0031 0.0246 0.1659
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0328
Schistosoma mansoni zinc finger protein 0.0016 0.0053 0.0041
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0046 0.043 0.0804
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0224 0.0386
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0437 0.0817
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0247 0.0434
Entamoeba histolytica protein kinase 2, putative 0.0029 0.0222 0.1699
Schistosoma mansoni hypothetical protein 0.0029 0.0224 0.0386
Plasmodium vivax protein kinase Crk2 0.0094 0.1033 0.1753
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0262 0.0463
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0561 0.4752
Brugia malayi Protein kinase domain containing protein 0.0175 0.2053 0.3607
Schistosoma mansoni tyrosine kinase 0.0021 0.012 0.0175
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0158 0.0253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.0353 0.0321
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0158 0.0126
Loa Loa (eye worm) raf kinase 0.0028 0.0207 0.0328
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0274 0.0487
Echinococcus multilocularis serine:threonine protein kinase 38 0.0044 0.0406 0.0374
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0274 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0129
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0597 0.5079
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0224 0.0386
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0094 0.0162
Echinococcus granulosus raf serine:threonine protein kinase 0.0033 0.0275 0.0489
Giardia lamblia Kinase, CMGC CDK 0.0094 0.1033 0.8206
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.035 0.0318
Schistosoma mansoni single-minded 0.0062 0.0633 0.1215
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.004 0.0354 0.0545
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0118 0.1331 0.2337
Echinococcus granulosus nervana 2 0.002 0.0113 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0546 0.4156
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.004 0.0353 0.2884
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0126
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0188 0.2212 0.2186
Schistosoma mansoni protein kinase C mu 0.0118 0.1331 0.2627
Brugia malayi nuclear receptor NHR-67 0.0016 0.0053 0.0023
Entamoeba histolytica protein kinase, putative 0.0066 0.0688 0.5903
Loa Loa (eye worm) hypothetical protein 0.004 0.0353 0.059
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0158 0.4902
Schistosoma mansoni rac gtpase activating protein 0.0028 0.0207 0.0352
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0274 0.0487
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.0561 0.0913
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1143 0.1977
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0053 0.0041
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0046 0.043 0.0398
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0772 0.1496
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0158 0.0222
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.004 0.0014
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0597 0.5079
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0047 0.0042
Echinococcus granulosus Ankyrin 0.0015 0.0042 0.0018
Loa Loa (eye worm) RasGEF domain-containing protein 0.0028 0.0207 0.0328
Echinococcus granulosus solute carrier family 22 0.0015 0.0047 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0406 0.0755
Echinococcus granulosus serine threonine protein kinase nrc 0.0029 0.0222 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1143 0.912
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0047 0.0011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0031 0.0246 0.1919
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0561 0.4275
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0029 0.0222 0.0382
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1208 0.2378
Echinococcus multilocularis Ankyrin 0.0015 0.0042 0.0009
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.1033 0.1003
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.1265 0.2494
Schistosoma mansoni vesicular amine transporter 0.0025 0.0167 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.035 0.0584
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0274 0.0487
Trypanosoma cruzi Protein kinase B 0.0031 0.0247 0.193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0274 0.0447
Schistosoma mansoni hypothetical protein 0.0408 0.4973 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0059 0.0228
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0561 0.4752
Loa Loa (eye worm) hypothetical protein 0.0025 0.0167 0.0257
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0038
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0158 1
Entamoeba histolytica hypothetical protein 0.0028 0.0207 0.1565
Toxoplasma gondii histone kinase SNF1, putative 0.0031 0.0246 0.0572
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0077 0.0089
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0094 0.1033 0.901
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0262 0.2063
Trypanosoma brucei glucose transporter, putative 0.0033 0.0276 0.2186
Schistosoma mansoni cpg binding protein 0.003 0.0237 0.0411
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0014 0.0033 0.0018
Treponema pallidum prolyl-tRNA synthetase 0.0011 0 0.5
Echinococcus multilocularis solute carrier family 22 0.0015 0.0047 0.0014
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0031 0.0246 0.1919
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.1033 0.901
Brugia malayi hypothetical protein 0.0015 0.0047 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0246 0.0431
Echinococcus multilocularis cyclin dependent kinase 5 0.0094 0.1033 0.1003
Trypanosoma brucei SNF1-related protein kinases, putative 0.0031 0.0246 0.1919
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0353 0.255
Toxoplasma gondii diacylglycerol kinase, putative 0.0028 0.0207 0.0466

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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