Detailed information for compound 1450467

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.234 | Formula: C18H15Cl2N3O6
  • H donors: 1 H acceptors: 5 LogP: 3.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1Cl)CN(C(=O)COC(=O)c1ccc(cc1[N+](=O)[O-])Cl)C
  • InChi: 1S/C18H15Cl2N3O6/c1-22(9-16(24)21-14-5-3-2-4-13(14)20)17(25)10-29-18(26)12-7-6-11(19)8-15(12)23(27)28/h2-8H,9-10H2,1H3,(H,21,24)
  • InChiKey: URDSCKPWSSDQON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0201 0.0193
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0301 0.0293
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0378 0.0532
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi CXXC zinc finger family protein 0.0028 0.0622 0.0884
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0273 0.0392
Schistosoma mansoni polycystin 1-related 0.0019 0.04 0.0393
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0201 0.0193
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0193 0.0267
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0193 0.0186
Echinococcus granulosus orexin receptor type 2 0.0011 0.0193 0.0186
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.04 0.0565
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0461 0.0652
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0461 0.0652
Schistosoma mansoni amine GPCR 0.0011 0.0193 0.0186
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0049 0.006
Brugia malayi Muscleblind-like protein 0.018 0.4468 0.6415
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0193 0.0186
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.0184 0.4548 0.653
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0201 0.0193
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0273 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0201 0.0278
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0461 0.0652
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0193 0.0186
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0461 0.0652
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0201 0.0193
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0066 0.0058
Echinococcus multilocularis 0.0022 0.0461 0.0453
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trypanosoma brucei cytochrome P450, putative 0.004 0.0925 0.132
Echinococcus multilocularis RUN 0.0019 0.04 0.0393
Echinococcus granulosus single minded 2 0.004 0.0936 0.0929
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.009 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0049 0.0042
Brugia malayi ecdysone receptor 0.0005 0.0049 0.006
Brugia malayi hypothetical protein 0.0006 0.0066 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0193 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0201 0.0278
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0193 0.0186
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0193 0.0267
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1845 0.1839
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0201 0.0193
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0301 0.0293
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0301 0.0421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1242 0.1776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0193 0.0267
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0049 0.006
Schistosoma mansoni cpg binding protein 0.0028 0.0622 0.0615
Leishmania major protein kinase, putative 0.0015 0.0285 0.0399
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.4189 0.6014
Echinococcus granulosus g protein coupled receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) CYP4Cod1 0.004 0.0925 0.132
Schistosoma mansoni cytochrome P450 0.0022 0.0461 0.0453
Echinococcus multilocularis muscleblind protein 0.018 0.4468 0.4464
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1845 0.1839
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0461 0.1486
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Schistosoma mansoni adenoreceptor 0.0011 0.0193 0.0186
Echinococcus granulosus Ankyrin 0.0014 0.0269 0.0261
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0049 0.0042
Brugia malayi nuclear hormone receptor 0.0005 0.0049 0.006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1242 0.1776
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0193 0.0186
Schistosoma mansoni myosin xvIII 0.0011 0.0193 0.0186
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0301 0.0421
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0193 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0193 0.0186
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.04 0.0393
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0193 0.0186
Echinococcus multilocularis somatostatin receptor 0.0011 0.0193 0.0186
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0301 0.0421
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.04 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0461 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0201 0.0278
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0193 0.0186
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0266 0.0258
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0193 0.0186
Schistosoma mansoni zinc finger protein 0.0005 0.0049 0.0042
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0201 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0201 0.0278
Schistosoma mansoni biogenic amine receptor 0.0011 0.0193 0.0186
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0193 0.0186
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0461 0.0652
Schistosoma mansoni biogenic amine receptor 0.0011 0.0193 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1242 0.1784
Plasmodium falciparum eukaryotic initiation factor 4A 0.0279 0.696 1
Echinococcus granulosus death domain containing protein 0.0014 0.0266 0.0258
Brugia malayi isocitrate dehydrogenase 0.0015 0.0301 0.0421
Brugia malayi hypothetical protein 0.0005 0.0049 0.006
Schistosoma mansoni hypothetical protein 0.0011 0.0193 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0461 0.0652
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0266 0.0258
Trypanosoma brucei protein kinase, putative 0.0053 0.1242 0.1776
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0049 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0201 0.0193
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0461 0.0652
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0049 0.0042
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0273 0.0382
Loa Loa (eye worm) hypothetical protein 0.0006 0.0066 0.0083
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0273 0.0392
Loa Loa (eye worm) hypothetical protein 0.0018 0.0379 0.0534
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0066 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0193 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1242 0.1784
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0193 0.0267
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0201 0.0193
Loa Loa (eye worm) hypothetical protein 0.0006 0.0066 0.0083
Loa Loa (eye worm) RNA binding protein 0.0076 0.1845 0.2643
Brugia malayi Death domain containing protein 0.0014 0.0266 0.0371
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0461 0.0652
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0461 0.1486
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0201 0.0193
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1845 0.1839
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0004 0.0008 0.0011
Brugia malayi nuclear receptor RXR 0.0006 0.0066 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0461 0.0652
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0273 0.0392
Schistosoma mansoni hypothetical protein 0.0011 0.0193 0.0186
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0193 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0201 0.0278
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0193 0.0186
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0193 0.0186
Onchocerca volvulus 0.0011 0.0193 0.0267
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0301 0.0421
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Echinococcus granulosus somatostatin receptor 0.0011 0.0193 0.0186
Leishmania major eukaryotic initiation factor 4a, putative 0.0279 0.696 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0049 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0461 0.1486
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0193 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi Serotonin receptor 0.0011 0.0193 0.0267
Echinococcus granulosus g protein coupled receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Brugia malayi neuropeptide F receptor 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus geminin 0.0164 0.406 0.4056
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0193 0.0186
Onchocerca volvulus 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0074 0.0107
Brugia malayi Uncoordinated protein 44 0.0014 0.0266 0.0371
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0201 0.0193
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0461 0.0652
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.04 0.0565
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0461 0.1486
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0193 0.0186
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0193 0.0186
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0378 0.0543
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0794 0.0787
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0378 0.0532
Echinococcus granulosus hypothetical protein 0.0011 0.0193 0.0186
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0279 0.696 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0269 0.0376
Loa Loa (eye worm) hypothetical protein 0.018 0.4468 0.6415
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0378 0.0532
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0279 0.696 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0273 0.0266
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Brugia malayi PAS domain containing protein 0.0055 0.1295 0.1852
Brugia malayi RNA binding protein 0.0076 0.1845 0.2643
Echinococcus granulosus muscleblind protein 0.018 0.4468 0.4464
Schistosoma mansoni hypothetical protein 0.0014 0.0266 0.0258
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0273 0.0266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0301 0.0421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0193 0.0186
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0378 0.0532
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0925 0.132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Echinococcus granulosus sex peptide receptor 0.0011 0.0193 0.0186
Brugia malayi Melatonin receptor type 1A 0.0011 0.0193 0.0267
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0936 0.0929
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0193 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Brugia malayi nuclear hormone receptor 0.0011 0.0201 0.0278
Brugia malayi Dopamine receptor protein 2 0.0011 0.0193 0.0267
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0193 0.0186
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0201 0.0193
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0193 0.0267
Schistosoma mansoni opsin-like receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni neuropeptide receptor 0.0011 0.0193 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Onchocerca volvulus 0.0011 0.0193 0.0267
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) DR-78 0.0005 0.0049 0.006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0378 0.5
Brugia malayi Cytochrome P450 family protein 0.004 0.0925 0.132
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1242 0.1235
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0201 0.0278
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0279 0.696 0.6958
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0461 0.0652
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0201 0.0193
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi AKH receptor 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0193 0.0186
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0193 0.0186
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0273 0.0392
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0461 0.0652
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0279 0.696 1
Onchocerca volvulus 0.0005 0.0049 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0201 0.0193
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi Serotonin receptor 0.0011 0.0193 0.0267
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0301 0.0421
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0925 0.132
Brugia malayi larval opioid receptor 0.0011 0.0193 0.0267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0378 0.0532
Onchocerca volvulus 0.0019 0.04 0.0565
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0049 0.0042
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0049 0.006
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1242 0.1235
Schistosoma mansoni single-minded 0.0055 0.1295 0.1289
Brugia malayi cytochrome P450 0.0022 0.0461 0.0652
Brugia malayi tailless protein 0.0005 0.0049 0.006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0193 0.0186
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0049 0.006
Echinococcus granulosus neuropeptide receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0049 0.0042
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0461 0.1486
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0201 0.0278
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0193 0.0186
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0461 0.1486
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0133 0.0126
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0201 0.0278
Entamoeba histolytica hypothetical protein 0.0035 0.0794 0.1132
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0049 0.0042
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0049 0.0042
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0201 0.0193
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0622 0.0884
Schistosoma mansoni rab6-interacting 0.0019 0.04 0.0393
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0049 0.006
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1845 0.1839
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1845 0.2643
Onchocerca volvulus 0.0011 0.0193 0.0267
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0193 0.0186
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.04 0.0393
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0201 0.0193
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0279 0.696 1
Leishmania major cytochrome p450-like protein 0.0022 0.0461 0.0652
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0193 0.0186
Mycobacterium ulcerans putative regulatory protein 0.004 0.0936 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0378 0.037
Brugia malayi nuclear receptor NHR-67 0.0005 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0301 0.0421
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0301 0.0421
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0301 0.0293
Schistosoma mansoni amine GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1242 0.1235
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0461 0.1486
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0301 0.0293
Schistosoma mansoni opsin-like receptor 0.0011 0.0193 0.0186
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0193 0.0186
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0193 0.0186
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trichomonas vaginalis Phospholipase C precursor, putative 0.0004 0.0008 0.0011
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0461 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0201 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0201 0.0278
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Onchocerca volvulus 0.0011 0.0193 0.0267
Onchocerca volvulus 0.0011 0.0193 0.0267
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0279 0.696 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0201 0.0278
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0193 0.0186
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0049 0.006
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0193 0.0267
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0193 0.0186
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.04 0.0393
Schistosoma mansoni rab6-interacting 0.0019 0.04 0.0393
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0066 0.0083
Schistosoma mansoni amine GPCR 0.0011 0.0193 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0201 0.0193
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.04 0.0393
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.04 0.0393
Brugia malayi Cytochrome P450 family protein 0.004 0.0925 0.132
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0378 0.0532
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0193 0.0186
Brugia malayi hypothetical protein 0.0006 0.0066 0.0083
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0049 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0201 0.0193
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0461 0.1486
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0266 0.0258
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0301 0.0421
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0193 0.0267
Loa Loa (eye worm) cytochrome P450 0.0022 0.0461 0.0652
Loa Loa (eye worm) hypothetical protein 0.0014 0.0266 0.0371
Entamoeba histolytica hypothetical protein 0.0035 0.0794 0.1132
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0201 0.0278
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0193 0.0186
Toxoplasma gondii exonuclease III APE 0.0018 0.0378 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.013 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus RUN 0.0019 0.04 0.0393
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0461 0.1486
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0461 0.1486
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0201 0.0278
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0461 0.0652
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0378 0.0532
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0193 0.0186
Echinococcus granulosus tar DNA binding protein 0.0076 0.1845 0.1839
Brugia malayi putative neuropeptide receptor 0.0011 0.0193 0.0267
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0461 0.1486
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi nuclear receptor NHR-88 0.0005 0.0049 0.006
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0266 0.0258
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0201 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0193 0.0267
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0066 0.0058
Brugia malayi bHLH-PAS transcription factor 0.004 0.0936 0.1336
Schistosoma mansoni hypothetical protein 0.0164 0.406 0.4056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0015 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0273 0.0392
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0794 0.0787
Brugia malayi hypothetical protein 0.0019 0.04 0.0565
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Schistosoma mansoni histamine h1 receptor 0.0011 0.0193 0.0186
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0193 0.0267
Schistosoma mansoni coup transcription factor 0.0011 0.0201 0.0193
Brugia malayi RE15519p 0.0011 0.0193 0.0267
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0279 0.696 0.6958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0074 0.0107
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0461 0.1486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0201 0.0278
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Brugia malayi Dopamine receptor 0.0011 0.0193 0.0267
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0008 0.0011
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0269 0.0261
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1242 0.1776
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0193 0.0186
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0279 0.696 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Schistosoma mansoni neuropeptide receptor 0.0011 0.0193 0.0186
Brugia malayi G-protein coupled receptor 0.0011 0.0193 0.0267
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Leishmania major protein kinase, putative 0.0015 0.0285 0.0399
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0193 0.0186
Onchocerca volvulus 0.0011 0.0193 0.0267
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi conserved hypotetical protein 0.0005 0.0049 0.006
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0193 0.0186
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0201 0.0278
Onchocerca volvulus 0.0011 0.0193 0.0267
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0461 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0201 0.0278
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0461 0.0652
Brugia malayi neuropeptide F receptor 0.0011 0.0193 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0201 0.0278
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1275 0.1269
Mycobacterium leprae putative cytochrome p450 0.0022 0.0461 1
Brugia malayi TAR-binding protein 0.0076 0.1845 0.2643
Echinococcus granulosus g protein coupled receptor 0.0011 0.0193 0.0186
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0193 0.0186
Brugia malayi Cytochrome P450 family protein 0.0022 0.0461 0.0652
Brugia malayi G protein-coupled receptor 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0461 0.1486
Loa Loa (eye worm) hypothetical protein 0.0014 0.0273 0.0382
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0201 0.0193
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0461 0.0652
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1242 0.1776
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0461 0.0652
Brugia malayi Cytochrome P450 family protein 0.008 0.1926 0.2759
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1242 0.1235
Onchocerca volvulus 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.04 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0201 0.0278
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0461 0.1486
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1242 0.1784
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1242 0.1776
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0279 0.696 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0193 0.0186
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0279 0.696 0.6958
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0266 0.0371
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1242 0.1776
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0193 0.0186
Brugia malayi hypothetical protein 0.0005 0.0049 0.006
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0461 0.0652
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1242 0.1235
Echinococcus granulosus serotonin receptor 0.0011 0.0193 0.0186
Brugia malayi hypothetical protein 0.0035 0.0794 0.1132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0133 0.0126
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0273 0.0382
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0461 0.1486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0201 0.0278
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.009 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0049 0.0042
Schistosoma mansoni cpg binding protein 0.003 0.0662 0.0655
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0301 0.0293
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0285 0.0399
Loa Loa (eye worm) hypothetical protein 0.0006 0.0066 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Schistosoma mansoni lipoxygenase 0.0019 0.04 0.0393
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0193 0.0267
Loa Loa (eye worm) doublecortin family protein 0.0019 0.04 0.0565
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0461 0.0652
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi nuclear receptor NHR-88 0.0011 0.0201 0.0278
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0193 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0461 0.0652
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0066 0.0083
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0193 0.0267
Onchocerca volvulus 0.0014 0.0273 0.0382
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.009 0.0082
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0266 0.0258
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0214 0.532 0.5316
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1242 0.1784
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0049 0.0042
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0279 0.696 1
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0193 0.0267
Schistosoma mansoni hypothetical protein 0.0011 0.0193 0.0186
Brugia malayi sulfakinin receptor protein 0.0011 0.0193 0.0267
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0378 0.0543
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0008 0.0011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0066 0.0058
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0378 0.0532
Onchocerca volvulus 0.0011 0.0193 0.0267
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0461 0.0652
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0925 0.132
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0193 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0461 0.1486
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0201 0.0193
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0285 0.0399
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Brugia malayi hypothetical protein 0.0019 0.04 0.0565
Schistosoma mansoni neuropeptide receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0193 0.0267
Echinococcus granulosus fmrfamide receptor 0.0011 0.0193 0.0186
Echinococcus multilocularis serotonin receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.006
Schistosoma mansoni neuropeptide receptor 0.0011 0.0193 0.0186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0074 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0201 0.0278
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1845 0.1839
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0201 0.0193
Brugia malayi hypothetical protein 0.0184 0.4548 0.653
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0273 0.0266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.009 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0201 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0201 0.0278
Onchocerca volvulus 0.0028 0.0622 0.0884
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus multilocularis serotonin receptor 0.0011 0.0193 0.0186
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1416 0.141
Brugia malayi nuclear receptor RXR 0.0005 0.0049 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0004 0.0008 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Echinococcus multilocularis muscleblind protein 1 0.018 0.4468 0.4464
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0193 0.0186
Schistosoma mansoni opsin-like receptor 0.0011 0.0193 0.0186
Plasmodium vivax RNA helicase-1, putative 0.0279 0.696 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0285 0.0399
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0201 0.0193
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0193 0.0186
Leishmania major eukaryotic initiation factor 4a, putative 0.0279 0.696 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0461 0.1486
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0049 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0193 0.0267
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0193 0.0186
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0201 0.0193
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0193 0.0186
Echinococcus granulosus neuropeptide receptor 0.0011 0.0193 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0461 0.0652
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0279 0.696 1
Onchocerca volvulus 0.0005 0.0049 0.006
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0193 0.0186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0266 0.0371
Brugia malayi eukaryotic initiation factor 4A 0.0279 0.696 1
Entamoeba histolytica hypothetical protein 0.0035 0.0794 0.1132
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0193 0.0186
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1242 0.1776
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0925 0.132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0201 0.0193
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.1295 0.1289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0193 0.0186
Onchocerca volvulus 0.0011 0.0193 0.0267
Echinococcus multilocularis sex peptide receptor 0.0011 0.0193 0.0186
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0006 0.0066 0.0083
Onchocerca volvulus 0.0011 0.0193 0.0267
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0049 0.0042
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0273 0.0392
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0273 0.0382
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0193 0.0186
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0193 0.0267
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0378 0.0532
Echinococcus granulosus allatostatin A receptor 0.0011 0.0193 0.0186
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0273 0.5
Brugia malayi Dopamine receptor protein 1 0.0011 0.0193 0.0267
Brugia malayi G-protein coupled receptor 0.0011 0.0193 0.0267
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0285 0.0399
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0201 0.0278
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0004 0.0008 0.0011
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0004 0.0008 0.0011
Brugia malayi ecdysteroid receptor 0.0011 0.0201 0.0278
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi steroid hormone receptor 0.0011 0.0201 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0201 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0193 0.0186
Brugia malayi ORL1-like opioid receptor 0.0011 0.0193 0.0267
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0193 0.0267
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1275 0.1269
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.009 0.0082
Onchocerca volvulus 0.0011 0.0193 0.0267
Schistosoma mansoni nuclear receptor 0.0005 0.0049 0.0042
Onchocerca volvulus 0.0011 0.0193 0.0267
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0201 0.0193
Schistosoma mansoni ap endonuclease 0.0018 0.0378 0.037
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0133 0.018
Schistosoma mansoni biogenic amine receptor 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni hypothetical protein 0.0011 0.0193 0.0186
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.1926 0.2759
Loa Loa (eye worm) hypothetical protein 0.018 0.4468 0.6415
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0201 0.0193
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0925 0.9809
Schistosoma mansoni cpg binding protein 0.003 0.0662 0.0655
Onchocerca volvulus 0.004 0.0936 0.1336
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0461 0.1486
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0049 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0193 0.0186
Treponema pallidum ATP-dependent RNA helicase 0.0279 0.696 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0301 0.0293
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0378 0.0532
Onchocerca volvulus 0.0019 0.04 0.0565
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0193 0.0186
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0006 0.0066 0.0083
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0193 0.0267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0201 0.0193
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0193 0.0186
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0193 0.0186
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1256 0.1795
Echinococcus multilocularis dnaJ subfamily B 0.04 1 1
Onchocerca volvulus 0.0011 0.0193 0.0267
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1845 0.2643
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Schistosoma mansoni netrin receptor unc5 0.0014 0.0266 0.0258
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0273 0.0392
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0201 0.0278
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0193 0.0186
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0201 0.0278
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0193 0.0186
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0461 0.1486
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0794 0.0787
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0201 0.0278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0049 0.0042
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0193 0.0186
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0279 0.696 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0273 0.0382
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1845 0.1839
Schistosoma mansoni hypothetical protein 0.0035 0.0794 0.0787
Loa Loa (eye worm) hypothetical protein 0.0279 0.696 1
Schistosoma mansoni amine GPCR 0.0011 0.0193 0.0186
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0266 0.0371
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0273 0.0266
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0378 0.0532
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0049 0.006
Schistosoma mansoni lipoxygenase 0.0054 0.1275 0.1269
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0201 0.0278
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0461 0.0652
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1242 0.1776
Echinococcus multilocularis geminin 0.0164 0.406 0.4056
Brugia malayi Doublecortin family protein 0.0019 0.04 0.0565
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Echinococcus granulosus cpg binding protein 0.003 0.0662 0.0655
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0201 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0301 0.0421
Leishmania major cytochrome p450-like protein 0.0022 0.0461 0.0652
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni hypothetical protein 0.0022 0.0461 0.0453
Onchocerca volvulus 0.0011 0.0193 0.0267
Entamoeba histolytica hypothetical protein 0.0035 0.0794 0.1132
Brugia malayi hypoxia-induced factor 1 0.0169 0.4189 0.6014
Schistosoma mansoni hypothetical protein 0.0019 0.04 0.0393
Schistosoma mansoni amine GPCR 0.0011 0.0193 0.0186
Echinococcus multilocularis Ankyrin 0.0014 0.0269 0.0261
Schistosoma mansoni hypothetical protein 0.0164 0.406 0.4056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0301 0.0293
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0378 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Schistosoma mansoni nuclear receptor 0.0005 0.0049 0.0042
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0193 0.0186
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0461 0.1486
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0461 0.0652
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0193 0.0186
Brugia malayi MAP kinase sur-1 0.0053 0.1242 0.1776
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0279 0.696 0.6958
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0279 0.696 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1242 0.1776
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0066 0.0058
Leishmania major cytochrome p450-like protein 0.004 0.0925 0.132
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Onchocerca volvulus 0.0011 0.0201 0.0278
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0301 0.0421
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0003 0.0000000031394 0.0000000045104
Onchocerca volvulus 0.0011 0.0193 0.0267
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0461 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0193 0.0186
Echinococcus granulosus eukaryotic initiation factor 4A 0.0279 0.696 0.6958
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0193 0.0186
Brugia malayi Protein kinase domain containing protein 0.0014 0.0278 0.0389
Echinococcus multilocularis cpg binding protein 0.003 0.0662 0.0655
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0273 0.0392
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0201 0.0193
Brugia malayi hypothetical protein 0.0011 0.0193 0.0267
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1845 0.2643
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0193 0.0186
Schistosoma mansoni loxhd1 0.0019 0.04 0.0393
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0193 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1242 0.1776
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0201 0.0193
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0193 0.0186
Schistosoma mansoni hypothetical protein 0.04 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0074 0.0107
Trichomonas vaginalis helicase, putative 0.0006 0.0074 0.0107
Echinococcus granulosus nuclear factor of activated T cells 5 0.0214 0.532 0.5316
Brugia malayi GnHR receptor homolog 0.0011 0.0193 0.0267
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0049 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0273 0.0392
Schistosoma mansoni ap endonuclease 0.0018 0.0378 0.037
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0279 0.696 0.6958
Loa Loa (eye worm) hypothetical protein 0.0019 0.04 0.0565
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0193 0.0186
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0301 0.0421
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0273 0.0392
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0004 0.0008 0.0011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0193 0.0186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0378 0.037
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0049 0.006
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0461 0.0453
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0193 0.0186

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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