TDR Targets

Basic information

Technical information

TDR Targets ID: 1451140
Name: 2-[4-(4-methylphenyl)-6-(trifluoromethyl)pyri midin-2-yl]sulfanyl-1-(3-nitrophenyl)ethanone
MW: 433.404 | Formula: C20H14F3N3O3S
H donors: 0 H acceptors: 5 LogP: 5.23 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)c1nc(SCC(=O)c2cccc(c2)[N+](=O)[O-])nc(c1)C(F)(F)F
InChi: 1S/C20H14F3N3O3S/c1-12-5-7-13(8-6-12)16-10-18(20(21,22)23)25-19(24-16)30-11-17(27)14-3-2-4-15(9-14)26(28)29/h2-10H,11H2,1H3
InChiKey: TWMLJWNCJZPSMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[4-(4-methylphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-1-(3-nitrophenyl)ethanone
2-[[4-(4-methylphenyl)-6-(trifluoromethyl)pyrimidin-2-yl]thio]-1-(3-nitrophenyl)ethanone
ZINC02875701
SMR000201180
2-{[4-(4-methylphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio}-1-(3-nitrophenyl)ethanone
MLS000581969

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0062	0.0165	0.0989
Toxoplasma gondii	methionyl-tRNA synthetase	0.0062	0.0165	0.0974
Loa Loa (eye worm)	zinc finger protein	0.0307	0.1032	0.1032
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.2887	0.2887
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0064	0.0172	0.8133
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0062	0.0062
Mycobacterium leprae	conserved hypothetical protein	0.0114	0.0351	0.8768
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0102	0.1239
Brugia malayi	diacylglycerol acyltransferase	0.0379	0.1283	0.1283
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.0334	0.1301
Schistosoma mansoni	cpg binding protein	0.0036	0.0073	0.0073
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0036	0.0036
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0064	0.0172	0.8133
Trichomonas vaginalis	penicillin-binding protein, putative	0.0114	0.0351	0.4289
Trypanosoma cruzi	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Toxoplasma gondii	ABC1 family protein	0.0114	0.0351	0.2105
Trypanosoma brucei	trypanothione reductase	0.0048	0.0117	0.0691
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0172	0.0172
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0064	0.0172	0.0172
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0062	0.0062
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0114	0.0351	0.1369
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0062	0.0165	0.4625
Schistosoma mansoni	hypothetical protein	0.0452	0.1542	0.1542
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.0334	0.1301
Trichomonas vaginalis	D-aminoacylase, putative	0.0114	0.0351	0.4289
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0117	0.0117
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0064	0.0172	0.0172
Loa Loa (eye worm)	hhat protein	0.0064	0.0172	0.0172
Echinococcus granulosus	cpg binding protein	0.0036	0.0073	0.0073
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0064	0.0172	0.0172
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0028	0.1347
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0028	0.0085
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.0334	0.1301
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.0172	0.0172
Loa Loa (eye worm)	MBOAT family protein	0.0064	0.0172	0.0172
Onchocerca volvulus	Huntingtin homolog	0.0135	0.0425	0.2516
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0351	0.0351
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0021	0.0023	0.0023
Trypanosoma cruzi	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.0334	0.1301
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.001	0.001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.025	0.083	0.083
Schistosoma mansoni	zinc finger protein	0.0022	0.0025	0.0025
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0064	0.0172	0.8133
Entamoeba histolytica	hypothetical protein	0.0073	0.0205	1
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.285	1	1
Trypanosoma brucei	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Schistosoma mansoni	methionine-tRNA synthetase	0.0024	0.0031	0.0031
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.025	0.083	0.083
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0015	0.0167
Brugia malayi	Zinc finger, C2H2 type family protein	0.0307	0.1032	0.1032
Schistosoma mansoni	sterol O-acyltransferase 1	0.0064	0.0172	0.0172
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0064	0.0172	0.0172
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0117	0.0866
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0117	0.0439
Schistosoma mansoni	hypothetical protein	0.007	0.0194	0.0194
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.007	0.0194	0.0194
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0114	0.0351	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0064	0.0172	0.0172
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Echinococcus granulosus	GPCR family 2	0.0032	0.0062	0.0062
Mycobacterium ulcerans	lipase LipD	0.0114	0.0351	1
Toxoplasma gondii	dgat2l1-prov protein	0.0481	0.1642	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.1059	0.1059
Mycobacterium tuberculosis	Probable reductase	0.0109	0.0334	0.1301
Treponema pallidum	leucyl-tRNA synthetase	0.0024	0.0031	0.1481
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0028	0.0324
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0028	0.0148
Trypanosoma brucei	hypothetical protein, conserved	0.0114	0.0351	0.2118
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.073	0.2523	1
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0481	0.1642	1
Mycobacterium leprae	Probable lipase LipE	0.0114	0.0351	0.8768
Leishmania major	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Onchocerca volvulus		0.0114	0.0351	0.2074
Schistosoma mansoni	chromobox protein	0.0073	0.0204	0.0204
Echinococcus multilocularis	zinc finger protein	0.0022	0.0025	0.0025
Entamoeba histolytica	hypothetical protein	0.0073	0.0205	1
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.0419	0.5126
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0028	0.0028
Brugia malayi	MBOAT family protein	0.0064	0.0172	0.0172
Onchocerca volvulus		0.0155	0.0493	0.2917
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0707	0.0707
Echinococcus multilocularis	zinc finger transcription factor gli2	0.0307	0.1032	0.1032
Leishmania major	leucyl-tRNA synthetase, putative	0.0024	0.0031	0.0166
Brugia malayi	Glycosylation related protein 12, isoform	0.0073	0.0205	0.0205
Leishmania major	diacylglycerol acyltransferase, putative	0.0481	0.1642	1
Brugia malayi	Pre-SET motif family protein	0.0216	0.0711	0.0711
Brugia malayi	CHD4 protein	0.0016	0.0003	0.0003
Trypanosoma cruzi	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0064	0.0172	0.0172
Leishmania major	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0172	0.2096
Brugia malayi	Pre-SET motif family protein	0.0032	0.0059	0.0059
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0064	0.0172	0.0172
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0064	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0351	0.0351
Brugia malayi	Bromodomain containing protein	0.004	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0308	0.0308
Brugia malayi	methionyl-tRNA synthetase	0.0024	0.0031	0.0031
Echinococcus granulosus	chromobox protein 1	0.0073	0.0204	0.0204
Schistosoma mansoni	chromobox protein	0.0073	0.0204	0.0204
Loa Loa (eye worm)	MBOAT family protein	0.0064	0.0172	0.0172
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.001	0.001
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0064	0.0172	0.0172
Onchocerca volvulus		0.0114	0.0351	0.2074
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0204	0.2489
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.0334	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0351	0.0351
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0006	0.0017
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0114	0.0351	0.1369
Schistosoma mansoni	hypothetical protein	0.0073	0.0205	0.0205
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0059	0.0059
Plasmodium falciparum	glutathione reductase	0.0048	0.0117	0.0866
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0062	0.0062
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0024	0.0031	0.0031
Loa Loa (eye worm)	beta-lactamase	0.0114	0.0351	0.0351
Mycobacterium tuberculosis	Conserved protein	0.0114	0.0351	0.1369
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0481	0.1642	0.1642
Leishmania major	methionyl-tRNA synthetase, putative	0.0062	0.0165	0.0989
Chlamydia trachomatis	leucine--tRNA ligase	0.0024	0.0031	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0064	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0481	0.1642	1
Onchocerca volvulus		0.0038	0.0082	0.0487
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0114	0.0351	0.0351
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.025	0.083	0.083
Schistosoma mansoni	hypothetical protein	0.0064	0.0172	0.0172
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.2887	0.2887
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0036	0.0036
Onchocerca volvulus		0.0032	0.0059	0.0352
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0006	0.0017
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0114	0.0351	0.0351
Loa Loa (eye worm)	MBOAT family protein	0.0064	0.0172	0.0172
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0006	0.006
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0006	0.0017
Onchocerca volvulus		0.0044	0.0101	0.0598
Brugia malayi	hypothetical protein	0.0073	0.0205	0.0205
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0117	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0206	0.0206
Entamoeba histolytica	hypothetical protein	0.0064	0.0172	0.8133
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0024	0.0031	0.0713
Onchocerca volvulus		0.0481	0.1642	0.9718
Brugia malayi	MBOAT family protein	0.0064	0.0172	0.0172
Brugia malayi	glutathione reductase	0.0048	0.0117	0.0117
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0064	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0493	0.0493
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0425	0.0425
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0172	0.2096
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0006	0.0006
Echinococcus multilocularis	sterol O acyltransferase 1	0.0064	0.0172	0.0172
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.025	0.083	0.083
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0024	0.0031	0.0175
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.285	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0028	0.0028
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0028	0.1294
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0172	0.2096
Mycobacterium tuberculosis	Conserved protein	0.0114	0.0351	0.1369
Schistosoma mansoni	leucyl-tRNA synthetase	0.0024	0.0031	0.0031
Echinococcus multilocularis	alpha 1,3 mannosyl glycoprotein	0.0215	0.0707	0.0707
Plasmodium vivax	SET domain protein, putative	0.0032	0.0059	0.0414
Echinococcus granulosus	zinc finger protein	0.0022	0.0025	0.0025
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.001	0.001
Mycobacterium ulcerans	hypothetical protein	0.0114	0.0351	1
Toxoplasma gondii	diacylglycerol acyltransferase	0.0106	0.0323	0.1936
Mycobacterium tuberculosis	Probable hydrolase	0.0114	0.0351	0.1369
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0114	0.0351	0.0351
Mycobacterium tuberculosis	Probable lipase LipD	0.0114	0.0351	0.1369
Entamoeba histolytica	vacuolar protein sorting 26	0.0064	0.0172	0.8133
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0707	0.0707
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0379	0.1283	0.7804
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Loa Loa (eye worm)	pax transcription factor protein 2	0.0494	0.169	0.169
Schistosoma mansoni	cpg binding protein	0.0032	0.0059	0.0059
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.025	0.083	0.083
Onchocerca volvulus		0.0032	0.006	0.0356
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0006	0.0006
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0062	0.0165	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.025	0.083	0.083
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0028	0.1347
Schistosoma mansoni	hypothetical protein	0.0347	0.1172	0.1172
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0172	0.0172
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0028	0.0148
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0091	0.1105
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0024	0.0031	0.015
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0032	0.0062	0.0062
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0379	0.1283	0.1283
Leishmania major	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Loa Loa (eye worm)	hypothetical protein	0.285	1	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0117	0.0117
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0121	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Schistosoma mansoni	ap endonuclease	0.0023	0.0028	0.0028
Trichomonas vaginalis	penicillin-binding protein, putative	0.0114	0.0351	0.4289
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0031
Trypanosoma cruzi	GUP1, putative	0.0064	0.0172	0.1029
Trichomonas vaginalis	porcupine, putative	0.0064	0.0172	0.2096
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0062	0.0062
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0012	0.0012
Entamoeba histolytica	hypothetical protein, conserved	0.0064	0.0172	0.8133
Brugia malayi	Thioredoxin reductase	0.0048	0.0117	0.0117
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0114	0.0351	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0049	0.059
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0079	0.0079
Toxoplasma gondii	exonuclease III APE	0.0023	0.0028	0.0131
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.0308	0.0308
Toxoplasma gondii	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.0073	0.0205	0.1216
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.0024	0.0031	0.1542
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0064	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0049	0.059
Loa Loa (eye worm)	hypothetical protein	0.004	0.0088	0.0088
Echinococcus granulosus	zinc finger transcription factor gli2	0.0307	0.1032	0.1032
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0036	0.0036
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0016	0.0003	0.0003
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0038	0.0082	0.0082
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0481	0.1642	0.1642
Mycobacterium tuberculosis	Probable lipase LipE	0.0114	0.0351	0.1369
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0102	0.0605
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0028	0.0148
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0064	0.0172	0.0172
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0024	0.0031	0.0192
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Leishmania major	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Leishmania major	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0204	0.2489
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0379	0.1283	0.1283
Echinococcus granulosus	alpha 13 mannosyl glycoprotein	0.0215	0.0707	0.0707
Echinococcus granulosus	dnaJ subfamily B	0.0452	0.1542	0.1542
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0351	0.0351
Echinococcus granulosus	beta LACTamase domain containing family member	0.0114	0.0351	0.0351
Leishmania major	trypanothione reductase	0.0048	0.0117	0.0691
Leishmania major	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0006	0.006
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Echinococcus granulosus	geminin	0.0347	0.1172	0.1172
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0121	0.0121
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.0308	0.0308
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Brugia malayi	beta-lactamase	0.0114	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0062	0.0062
Brugia malayi	protein ZK524.3	0.0024	0.0031	0.0031
Loa Loa (eye worm)	CHromoDomain protein family member	0.0016	0.0003	0.0003
Leishmania major	hypothetical protein, conserved	0.0114	0.0351	0.2118
Onchocerca volvulus		0.0494	0.169	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.0334	0.796
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0062	0.0062
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.0031	0.0192
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0167
Trypanosoma brucei	glycerol uptake protein, putative	0.0064	0.0172	0.1029
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.285	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0064	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0096
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.2887	0.2887
Plasmodium vivax	methionine--tRNA ligase, putative	0.0024	0.0031	0.0192
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0028	0.0324
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0062	0.0165	0.0633
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Brugia malayi	MBOAT family protein	0.0064	0.0172	0.0172
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0064	0.0172	0.0172
Trypanosoma cruzi	GUP1, putative	0.0064	0.0172	0.1029
Brugia malayi	GNT-I family protein	0.0215	0.0707	0.0707
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0062	0.0062
Echinococcus multilocularis	leucyl tRNA synthetase	0.0024	0.0031	0.0031
Giardia lamblia	Methionyl-tRNA synthetase	0.0062	0.0165	1
Leishmania major	hypothetical protein, conserved	0.0064	0.0172	0.1029
Brugia malayi	Heterochromatin protein 1	0.0073	0.0204	0.0204
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0028	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0003	0.0023
Toxoplasma gondii	mono- or diacylglycerol acyltransferase	0.0106	0.0323	0.1936
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0006	0.0017
Brugia malayi	beta-lactamase family protein	0.0114	0.0351	0.0351
Mycobacterium ulcerans	hypothetical protein	0.0106	0.0323	0.9198
Brugia malayi	methionyl-tRNA synthetase	0.0062	0.0165	0.0165
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.025	0.083	0.083
Chlamydia trachomatis	methionine--tRNA ligase	0.0024	0.0031	1
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.025	0.083	0.083
Plasmodium vivax	methionine--tRNA ligase, putative	0.0062	0.0165	0.1248
Schistosoma mansoni	cpg binding protein	0.0036	0.0073	0.0073
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0106	0.0323	0.0323
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0379	0.1283	0.7804
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0167
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0117	0.0676
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0379	0.1283	0.1283
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0155	0.0493	0.0493
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0064	0.0172	0.0172
Echinococcus multilocularis	methionine tRNA synthetase	0.0062	0.0165	0.0165
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0379	0.1283	0.1283
Leishmania major	hypothetical protein, unknown function,protein, unknown function	0.0106	0.0323	0.195
Schistosoma mansoni	hypothetical protein	0.0106	0.0323	0.0323
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0167
Schistosoma mansoni	alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase	0.0215	0.0707	0.0707
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.0377	0.1472
Toxoplasma gondii	hypothetical protein	0.0086	0.0249	0.1485
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0481	0.1642	1
Onchocerca volvulus		0.0064	0.0172	0.1018
Brugia malayi	MBOAT family protein	0.0064	0.0172	0.0172
Mycobacterium tuberculosis	Probable esterase LipL	0.0114	0.0351	0.1369
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0062	0.0165	0.2016
Schistosoma mansoni	hypothetical protein	0.0032	0.0062	0.0062
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0114	0.0351	0.1369
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0079	0.0079
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0006	0.0017
Loa Loa (eye worm)	hhat protein	0.0064	0.0172	0.0172
Brugia malayi	PHD-finger family protein	0.0028	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0016	0.0003	0.0003
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0204	0.0204
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.0377	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0006	0.0017
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0167
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0114	0.0351	0.0351
Schistosoma mansoni	methionine-tRNA synthetase	0.0062	0.0165	0.0165
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0205	0.0205
Treponema pallidum	alginate O-acetylation protein (algI)	0.0064	0.0172	1
Schistosoma mansoni	zinc finger protein	0.0064	0.0172	0.0172
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0059	0.0059
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0006	0.0017
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0064	0.0172	0.0172
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0189	0.0189
Entamoeba histolytica	hypothetical protein	0.0073	0.0205	1
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0102	0.1239
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0194	0.0194
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0044	0.0101	0.0101
Toxoplasma gondii	hypothetical protein	0.0064	0.0172	0.1014
Treponema pallidum	methionyl-tRNA synthetase	0.0024	0.0031	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0172	0.0172
Brugia malayi	chromobox protein homolog 3	0.0041	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0351	0.0351
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.025	0.083	0.083
Trichomonas vaginalis	D-aminoacylase, putative	0.0114	0.0351	0.4289
Brugia malayi	MBOAT family protein	0.0064	0.0172	0.0172
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0117	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0046	0.011	0.011
Mycobacterium tuberculosis	Conserved protein	0.0114	0.0351	0.1369
Echinococcus granulosus	sterol O acyltransferase 1	0.0064	0.0172	0.0172
Giardia lamblia	Leucyl-tRNA synthetase	0.0024	0.0031	0.1542
Schistosoma mansoni	ap endonuclease	0.0023	0.0028	0.0028
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0062	0.0062
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0167
Trichomonas vaginalis	D-aminoacylase, putative	0.0114	0.0351	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0172	0.0172
Schistosoma mansoni	hypothetical protein	0.0032	0.0062	0.0062
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0091	0.054
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.0816	1
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0064	0.0172	0.0172
Mycobacterium ulcerans	beta-lactamase	0.0114	0.0351	1
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Echinococcus granulosus	chromobox protein 1	0.0073	0.0204	0.0204
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0016	0.0003	0.0003
Echinococcus granulosus	methionine tRNA synthetase	0.0062	0.0165	0.0165
Onchocerca volvulus		0.0246	0.0816	0.4827
Echinococcus multilocularis	geminin	0.0347	0.1172	0.1172
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0053	0.0053
Brugia malayi	Pax transcription factor protein 2	0.0494	0.169	0.169
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0351	0.0351
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0062	0.0165	0.0165
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0425	0.0425
Brugia malayi	hypothetical protein	0.0135	0.0425	0.0425
Schistosoma mansoni	hypothetical protein	0.0347	0.1172	0.1172
Plasmodium vivax	hypothetical protein, conserved	0.0114	0.0351	0.2697
Onchocerca volvulus	Huntingtin homolog	0.0135	0.0425	0.2516
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0091	0.0091
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0064	0.0172	0.0172
Trypanosoma cruzi	hypothetical protein, conserved	0.0114	0.0351	0.2118
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.0377	0.1472
Mycobacterium ulcerans	esterase/lipase LipP	0.0114	0.0351	1
Echinococcus multilocularis	dnaJ subfamily B	0.0452	0.1542	0.1542
Brugia malayi	beta-lactamase family protein	0.0114	0.0351	0.0351
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0006	0.0017
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0059	0.0323
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0006	0.0017
Brugia malayi	Bromodomain containing protein	0.008	0.0228	0.0228
Echinococcus multilocularis	cpg binding protein	0.0036	0.0073	0.0073
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0064	0.0172	0.0172
Onchocerca volvulus		0.0114	0.0351	0.2074
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0031
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.001	0.001
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0379	0.1283	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.0308	0.0308
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0016	0.0003	0.0003
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0028	0.0148
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0117	0.0866
Entamoeba histolytica	hypothetical protein	0.0073	0.0205	1
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0204	0.0204
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0028	0.0028
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0062	0.0062
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0028	0.0028
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0024	0.0031	0.0031
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0028	0.0623
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0205	0.0205
Trichomonas vaginalis	esterase, putative	0.0114	0.0351	0.4289
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.0711	0.0711
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0006	0.0006
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0106	0.0323	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.072	0.8829
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.0172	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0032	0.006	0.006
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0006	0.0017
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0064	0.0172	0.2096
Leishmania major	diacylglycerol acyltransferase, putative	0.0106	0.0323	0.195
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0091	0.1105
Brugia malayi	diacylglycerol acyltransferase family protein	0.0481	0.1642	0.1642
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0015	0.0167
Brugia malayi	Hhat protein	0.0064	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0205	0.0205
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0205	0.0205
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0028	0.0168
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0379	0.1283	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0016	0.0003	0.0023
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0006	0.0006
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.0377	0.1472
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0059	0.0059
Schistosoma mansoni	zinc finger protein	0.0016	0.0003	0.0003
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.3402	0.3402
Plasmodium falciparum	methionine--tRNA ligase	0.0062	0.0165	0.1248
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0062	0.0165	0.0989
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0015	0.0167
Trypanosoma cruzi	hypothetical protein, conserved	0.0114	0.0351	0.2118
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0204	0.0204
Schistosoma mansoni	hypothetical protein	0.0032	0.0062	0.0062
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.0172	0.0172

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0158 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.3115 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1587025

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1451140