Detailed information for compound 1464774

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2037.19 | Formula: C91H125N6O34P2S4+
  • H donors: 16 H acceptors: 33 LogP: 2.07 Rotable bonds: 61
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=CCCC12CC3(NC(=O)CCCCCNC(=O)CCCCC[N+]4=C(/C=C/C5=C(Oc6ccc(cc6)S(=O)(=O)O)/C(=C/C=C\6/N(CCCCS(=O)(=O)O)c7c(C6(C)C)cc(cc7)S(=O)(=O)O)/CCC5)C(c5c4ccc(c5)S(=O)(=O)O)(C)C)CC(C2)(CC(C1)(C3)CCC(=O)N[C@H](C(=O)O)CCP(=O)(CC(C(=O)O)CCC(=O)O)O)CCC(=O)N[C@H](C(=O)O)CCP(=O)(CC(C(=O)O)CCC(=O)O)O
  • InChi: 1S/C91H124N6O34P2S4/c1-86(2)67-49-65(136(125,126)127)27-29-71(67)96(73(86)31-19-59-15-13-16-60(81(59)131-63-23-25-64(26-24-63)135(122,123)124)20-32-74-87(3,4)68-50-66(137(128,129)130)28-30-72(68)97(74)44-11-12-48-134(119,120)121)43-10-6-8-17-75(99)92-42-9-5-7-18-78(102)95-91-56-88(39-14-45-98)53-89(57-91,40-35-76(100)93-69(84(111)112)37-46-132(115,116)51-61(82(107)108)21-33-79(103)104)55-90(54-88,58-91)41-36-77(101)94-70(85(113)114)38-47-133(117,118)52-62(83(109)110)22-34-80(105)106/h19-20,23-32,45,49-50,61-62,69-70H,5-18,21-22,33-44,46-48,51-58H2,1-4H3,(H15-,92,93,94,95,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130)/p+1/t61?,62?,69-,70-,88?,89?,90?,91?/m0/s1
  • InChiKey: NTAHUPKTUOWCJU-GDDWPGSNSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hexokinase, putative 0.0537 0.0344 0.0931
Loa Loa (eye worm) hexokinase 0.0537 0.0344 0.4591
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0012 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0012 0.0011
Onchocerca volvulus 0.003 0.0001 0.0034
Loa Loa (eye worm) phosphatidylinositol 3 0.0226 0.0133 0.1782
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0012 0.0011
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0038 0.0007 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus neuropeptide receptor 0.0047 0.0012 0.0012
Loa Loa (eye worm) hexokinase 0.0166 0.0093 0.1245
Loa Loa (eye worm) phosphatidylinositol 3 0.1115 0.0734 0.9813
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0006 0.0147
Schistosoma mansoni myosin xvIII 0.0047 0.0012 0.016
Trypanosoma brucei hexokinase 0.0537 0.0344 0.4546
Trichomonas vaginalis PIKK family atypical protein kinase 0.1115 0.0734 0.9811
Echinococcus multilocularis neuropeptide s receptor 0.0515 0.0329 0.0327
Brugia malayi Dopamine receptor 0.0047 0.0012 0.0164
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1104 0.0726 0.9705
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1136 0.0748 0.9804
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0038 0.0007 0.0579
Brugia malayi Cytochrome P450 family protein 0.0038 0.0007 0.0092
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Echinococcus granulosus neuropeptide s receptor 0.0515 0.0329 0.0328
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0226 0.0133 0.0133
Brugia malayi hexokinase type II 0.0171 0.0096 0.1262
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0038 0.0007 0.0062
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0171 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.042 0.5572
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0651 0.0421 0.5516
Onchocerca volvulus 0.0047 0.0012 0.0363
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1136 0.0748 0.0747
Brugia malayi RE15519p 0.0047 0.0012 0.0164
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0476 0.0302 0.3989
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0038 0.0007 0.0062
Brugia malayi Cytochrome P450 family protein 0.0058 0.002 0.026
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0281 0.0171 0.2297
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0226 0.0133 0.1713
Trichomonas vaginalis PIKK family atypical protein kinase 0.1116 0.0735 0.9819
Schistosoma mansoni ap endonuclease 0.0037 0.0006 0.0079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0012 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.002 0.0266
Toxoplasma gondii target of rapamycin (TOR), putative 0.1124 0.074 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0065 0.0874
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0281 0.0171 0.4881
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0651 0.0421 0.1194
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0012 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0388 0.0243 0.3187
Schistosoma mansoni hexokinase 0.0537 0.0344 0.4391
Entamoeba histolytica hexokinase 2 0.0537 0.0344 0.4546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.0428 0.5685
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.0254 0.3338
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0038 0.0007 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0022 0.0281
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.1126 0.0741 0.9909
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0218 0.285
Brugia malayi Dopamine receptor protein 2 0.0047 0.0012 0.0164
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0012 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0012 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0012 0.0167
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0012 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.518 0.3479 1
Leishmania major cytochrome p450-like protein 0.0038 0.0007 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0121 0.0063 0.0843
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0038 0.0007 0.0579
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0226 0.0133 0.1704
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0226 0.0133 0.0366
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0038 0.0007 0.0579
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0011 0.0134
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus multilocularis serine protein kinase ATM 0.0646 0.0417 0.0416
Onchocerca volvulus 0.0047 0.0012 0.0363
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0012 0.0011
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0038 0.0007 0.0579
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0038 0.0007 0.0579
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0012 0.0011
Plasmodium falciparum hexokinase 0.0537 0.0344 1
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0012 0.0012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0012 0.016
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0008 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0038 0.0007 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0366 0.0228 0.3051
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0012 0.0164
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0012 0.0011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0012 0.0167
Trypanosoma brucei hexokinase 0.0537 0.0344 0.4546
Echinococcus granulosus serine protein kinase ATM 0.0646 0.0417 0.0417
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0226 0.0133 0.0133
Treponema pallidum hexokinase (hxk) 0.0537 0.0344 1
Echinococcus granulosus cytochrome P450 2K1 0.0038 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0226 0.0133 0.0366
Entamoeba histolytica hexokinase 1 0.0537 0.0344 0.4546
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0651 0.0421 0.5589
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0171 0.0454
Loa Loa (eye worm) cytochrome P450 0.0038 0.0007 0.0094
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1136 0.0748 1
Schistosoma mansoni neuropeptide receptor 0.0047 0.0012 0.016
Brugia malayi Hexokinase family protein 0.0337 0.0208 0.2731
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Brugia malayi GnHR receptor homolog 0.0047 0.0012 0.0164
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0012 0.0167
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1158 0.0763 0.0762
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0038 0.0007 0.0579
Schistosoma mansoni amine GPCR 0.0047 0.0012 0.016
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0281 0.0171 0.2219
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0012 0.0164
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0545 0.0349 0.4621
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.071 0.046 0.6119
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0038 0.0007 0.0062
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0839 0.0547 0.0547
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.002 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.0417 0.5535
Schistosoma mansoni biogenic amine receptor 0.0047 0.0012 0.016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0241 0.0144 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.1126 0.0741 0.9909
Trypanosoma cruzi target of rapamycin kinase 3 0.1126 0.0741 0.2117
Loa Loa (eye worm) hypothetical protein 0.0226 0.0133 0.1782
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0047 0.0012 0.016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0006 0.0005
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1136 0.0748 0.2047
Schistosoma mansoni hypothetical protein 0.04 0.0251 0.3213
Echinococcus granulosus serotonin receptor 0.0047 0.0012 0.0012
Echinococcus multilocularis neuropeptide receptor A26 0.0515 0.0329 0.0327
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0012 0.016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0457 0.029 0.3794
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0281 0.0171 0.2219
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0011 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.1126 0.0741 0.9909
Loa Loa (eye worm) hypothetical protein 0.0171 0.0096 0.1287
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0245 0.0147 0.1894
Brugia malayi cytochrome P450 0.0038 0.0007 0.0092
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0839 0.0547 0.6995
Brugia malayi Serotonin receptor 0.0047 0.0012 0.0164
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0012 0.0011
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0226 0.0133 0.0132
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0226 0.0133 0.1713
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0281 0.0171 0.2219
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0119 0.159
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0226 0.0133 0.1704
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0651 0.0421 0.1194
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0226 0.0133 0.1704
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1115 0.0734 0.9811
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0038 0.0007 0.0062
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0012 0.0363
Brugia malayi Hexokinase family protein 0.0166 0.0093 0.1221
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.006
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0038 0.0007 0.0579
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0646 0.0417 0.5535
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0012 0.0011
Brugia malayi putative neuropeptide receptor 0.0047 0.0012 0.0164
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0281 0.0171 0.2239
Schistosoma mansoni amine GPCR 0.0047 0.0012 0.016
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0038 0.0007 0.0579
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0226 0.0133 0.1704
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1136 0.0748 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Entamoeba histolytica hypothetical protein 0.0582 0.0374 0.4958
Trypanosoma cruzi hexokinase, putative 0.0537 0.0344 0.0971
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0226 0.0133 0.1747
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0281 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0171 0.0096 0.1287
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0012 0.016
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0012 0.016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0012 0.0164
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0545 0.0349 0.4621
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0646 0.0417 0.1183
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0457 0.029 0.387
Mycobacterium leprae conserved hypothetical protein 0.0226 0.0133 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Schistosoma mansoni fkbp-rapamycin associated protein 0.063 0.0406 0.5192
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0012 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0038 0.0007 0.0062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0012 0.0011
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0457 0.029 0.029
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0171 0.2219
Echinococcus granulosus neuropeptide receptor 0.1187 0.0782 0.0782
Echinococcus multilocularis hexokinase type 2 0.0537 0.0344 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Echinococcus multilocularis serotonin receptor 0.0047 0.0012 0.0011
Toxoplasma gondii FATC domain-containing protein 0.0646 0.0417 0.5629
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0012 0.016
Toxoplasma gondii exonuclease III APE 0.0037 0.0006 0.0068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0012 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0001 0.0015
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0012 0.0164
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Giardia lamblia Phosphatidylinositol 4-kinase 0.0226 0.0133 0.1713
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0641 0.0414 0.5496
Schistosoma mansoni cpg binding protein 0.003 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Schistosoma mansoni hypothetical protein 0.0047 0.0012 0.016
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0012 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0012 0.0167
Leishmania major phosphatidylinositol 3-kinase, putative 0.1104 0.0726 0.1987
Echinococcus granulosus hypothetical protein 0.0047 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0038 0.0007 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1126 0.0741 0.9909
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Onchocerca volvulus 0.0047 0.0012 0.0363
Loa Loa (eye worm) hypothetical protein 0.003 0.0001 0.0016
Echinococcus multilocularis hexokinase 0.0537 0.0344 0.0342
Echinococcus granulosus allatostatin A receptor 0.0047 0.0012 0.0012
Echinococcus granulosus g protein coupled receptor 0.0047 0.0012 0.0012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0012 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.002 0.0039
Leishmania major hypothetical protein, conserved 0.5406 0.3631 1
Schistosoma mansoni cpg binding protein 0.003 0.0001 0.0014
Brugia malayi Cytochrome P450 family protein 0.0121 0.0063 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0474 0.0301 0.3975
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0038 0.0007 0.0579
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Brugia malayi FAT domain containing protein 0.0474 0.0301 0.3946
Brugia malayi AKH receptor 0.0047 0.0012 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.1104 0.0726 0.9705
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0001 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0218 0.2853
Mycobacterium tuberculosis Conserved hypothetical protein 0.0226 0.0133 1
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0012 0.016
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0351 0.0218 0.0609
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0226 0.0133 0.1713
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Schistosoma mansoni cytochrome P450 0.0038 0.0007 0.009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0006 0.5
Schistosoma mansoni hypothetical protein 0.0474 0.0301 0.385
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.002 0.0039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0047 0.0012 0.016
Loa Loa (eye worm) phosphatidylinositol 3 0.0226 0.0133 0.1782
Entamoeba histolytica protein kinase rad3, putative 0.063 0.0406 0.539
Schistosoma mansoni histamine h1 receptor 0.0047 0.0012 0.016
Echinococcus multilocularis serotonin receptor 0.0047 0.0012 0.0011
Brugia malayi Cytochrome P450 family protein 0.0058 0.002 0.026
Echinococcus granulosus serine:threonine protein kinase SMG1 0.063 0.0406 0.0406
Echinococcus multilocularis 0.0038 0.0007 0.0006
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0281 0.0171 0.2284
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0651 0.0421 0.5589
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0281 0.0171 0.4956
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0038 0.0007 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1104 0.0726 0.9705
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0281 0.0171 0.2219
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Onchocerca volvulus 0.0337 0.0208 0.6068
Echinococcus granulosus hexokinase 0.0537 0.0344 0.0343
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0012 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0426 0.0269 0.3536
Trypanosoma cruzi hexokinase, putative 0.0537 0.0344 0.0971
Schistosoma mansoni opsin-like receptor 0.0047 0.0012 0.016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1158 0.0763 0.218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0001 0.0015
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0038 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.042 0.5572
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0012 0.016
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0038 0.0007 0.0579
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0012 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0012 0.0012
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1136 0.0748 0.9563
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0226 0.0133 0.1713
Onchocerca volvulus 0.0047 0.0012 0.0363
Leishmania major phosphatidylinositol kinase related protein, putative 0.0241 0.0144 0.038
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Schistosoma mansoni amine GPCR 0.0047 0.0012 0.016
Brugia malayi hexokinase 0.0537 0.0344 0.4501
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1158 0.0763 0.0763
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0351 0.0218 0.285
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0038 0.0007 0.0062
Entamoeba histolytica hypothetical protein 0.0646 0.0417 0.5535
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus dnaJ subfamily B 0.04 0.0251 0.0251
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0012 0.016
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0012 0.0011
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1136 0.0748 0.2047
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0038 0.0007 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0038 0.0007 0.0062
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0226 0.0133 0.0133
Schistosoma mansoni biogenic amine receptor 0.0047 0.0012 0.016
Echinococcus granulosus orexin receptor type 2 0.0047 0.0012 0.0012
Loa Loa (eye worm) hexokinase 0.0337 0.0208 0.2786
Onchocerca volvulus 0.0047 0.0012 0.0363
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0012 0.016
Leishmania major cytochrome p450-like protein 0.0038 0.0007 0.0002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0012 0.0167
Giardia lamblia GTOR 0.1136 0.0748 1
Onchocerca volvulus 0.0047 0.0012 0.0363
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0012 0.0012
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1126 0.0741 0.991
Schistosoma mansoni neuropeptide receptor 0.0047 0.0012 0.016
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.4839 1 1
Onchocerca volvulus 0.0232 0.0138 0.4017
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Plasmodium vivax hypothetical protein 0.0226 0.0133 0.386
Toxoplasma gondii hexokinase 0.0537 0.0344 0.4635
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0012 0.0011
Brugia malayi G-protein coupled receptor 0.0047 0.0012 0.0164
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0012 0.016
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0012 0.0164
Loa Loa (eye worm) CYP4Cod1 0.0058 0.002 0.0266
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0038 0.0007 0.0002
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0226 0.0133 0.386
Leishmania major hypothetical protein, unknown function 0.0226 0.0133 0.0351
Loa Loa (eye worm) hypothetical protein 0.042 0.0265 0.3536
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0038 0.0007 0.0062
Onchocerca volvulus 0.0537 0.0344 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0038 0.0007 0.0579
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0038 0.0007 0.0062
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0281 0.0171 0.2219
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1136 0.0748 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0295 0.018 0.2345
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0195 0.0112 0.1502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Schistosoma mansoni biogenic amine receptor 0.0047 0.0012 0.016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) phosphatidylinositol 3 0.0226 0.0133 0.1782
Echinococcus granulosus hexokinase 0.0537 0.0344 0.0343
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0226 0.0133 0.0366
Echinococcus granulosus neuropeptide receptor A26 0.0515 0.0329 0.0328
Brugia malayi neuropeptide F receptor 0.0047 0.0012 0.0164
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0012 0.0012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1136 0.0748 0.2137
Brugia malayi Pre-SET motif family protein 0.003 0.0001 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Onchocerca volvulus 0.0047 0.0012 0.0363
Schistosoma mansoni amine GPCR 0.0047 0.0012 0.016
Loa Loa (eye worm) hexokinase type II 0.0537 0.0344 0.4591
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Brugia malayi sulfakinin receptor protein 0.0047 0.0012 0.0164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0018 0.0224
Schistosoma mansoni hypothetical protein 0.0047 0.0012 0.016
Echinococcus multilocularis neuropeptide receptor 0.1187 0.0782 0.0781
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0218 0.285
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0008 0.0105
Echinococcus granulosus fmrfamide receptor 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0038 0.0007 0.0062
Onchocerca volvulus 0.0226 0.0133 0.3881
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0226 0.0133 0.386
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0457 0.029 0.0289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0012 0.016
Echinococcus granulosus cpg binding protein 0.003 0.0001 0.0001
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0474 0.0301 0.03
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Leishmania major phosphatidylinositol 3-kinase, putative 0.0281 0.0171 0.0454
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0012 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0006 0.0081
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0012 0.0011
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0226 0.0133 0.3768
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0012 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.1187 0.0782 0.0781
Leishmania major hexokinase, putative 0.0537 0.0344 0.0931
Schistosoma mansoni neuropeptide receptor 0.0047 0.0012 0.016
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0038 0.0007 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0254 0.3338
Echinococcus granulosus g protein coupled receptor 0.0047 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.0037 0.0006 0.0079
Echinococcus granulosus g protein coupled receptor 0.0047 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0722 0.0469 0.6232
Entamoeba histolytica hypothetical protein 0.0226 0.0133 0.1713
Onchocerca volvulus 0.0047 0.0012 0.0363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0001 0.0000081059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0012 0.0012
Leishmania major cytochrome p450-like protein 0.0058 0.002 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0012 0.016
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0038 0.0007 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0226 0.0133 0.1713
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0226 0.0133 0.3768
Toxoplasma gondii cytochrome p450 superfamily protein 0.0038 0.0007 0.0079
Loa Loa (eye worm) hypothetical protein 0.063 0.0406 0.5429
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0038 0.0007 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1136 0.0748 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.0047 0.0012 0.016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0012 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Echinococcus multilocularis Zinc finger, PHD finger 0.0281 0.0171 0.017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0226 0.0133 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0651 0.0421 0.5589
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0038 0.0007 0.0579
Onchocerca volvulus 0.0047 0.0012 0.0363
Schistosoma mansoni hypothetical protein 0.0038 0.0007 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Onchocerca volvulus 0.0047 0.0012 0.0363
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0226 0.0133 0.1713
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0218 0.2783
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0012 0.0012
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0281 0.0171 0.2184
Onchocerca volvulus 0.0047 0.0012 0.0363
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0001 0.0000081059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0646 0.0417 0.5463
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Echinococcus granulosus sex peptide receptor 0.0047 0.0012 0.0012
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0281 0.0171 0.0474
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0012 0.0164
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0012 0.016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0038 0.0007 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0038 0.0007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Brugia malayi neuropeptide F receptor 0.0047 0.0012 0.0164
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0281 0.0171 0.0171
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0012 0.0363
Schistosoma mansoni opsin-like receptor 0.0047 0.0012 0.016
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0012 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.1136 0.0748 1
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0012 0.0011
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1158 0.0763 0.218
Echinococcus granulosus hexokinase 0.0537 0.0344 0.0343
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0226 0.0133 0.1747
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0582 0.0374 0.4958
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0012 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Loa Loa (eye worm) phosphatidylinositol kinase 0.0226 0.0133 0.1782
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.1104 0.0726 0.9705
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0839 0.0547 0.0546
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0125 0.0065 0.017
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0012 0.0012
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0226 0.0133 0.386
Leishmania major phosphatidylinositol kinase, putative 0.0226 0.0133 0.0351
Echinococcus multilocularis dnaJ subfamily B 0.04 0.0251 0.025
Echinococcus multilocularis hexokinase 0.0537 0.0344 0.0342
Loa Loa (eye worm) phosphatidylinositol 3 0.0226 0.0133 0.1782
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Onchocerca volvulus Hexokinase homolog 0.0337 0.0208 0.6068
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.1114 0.0733 0.9796
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0651 0.0421 0.5589
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0012 0.0011
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0038 0.0007 0.0579
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1582 0.1049 0.1048
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0038 0.0007 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0652 0.0421 0.5594
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0012 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.1136 0.0748 1
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0138 0.1776
Leishmania major phosphatidylinositol 4-kinase, putative 0.0226 0.0133 0.0351
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.042 0.5572
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.063 0.0406 0.0405
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0226 0.0133 0.1789
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0012 0.0012
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0281 0.0171 0.2184
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0012 0.016
Echinococcus multilocularis sex peptide receptor 0.0047 0.0012 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0012 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0012 0.0167
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1126 0.0741 0.2028
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0646 0.0417 0.5329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0226 0.0133 0.1713
Echinococcus granulosus hexokinase type 2 0.0537 0.0344 0.0343
Brugia malayi Melatonin receptor type 1A 0.0047 0.0012 0.0164
Echinococcus multilocularis hexokinase 0.0537 0.0344 0.0342
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0226 0.0133 0.0132
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0218 0.285
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0038 0.0007 0.0062
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0038 0.0007 0.0062
Onchocerca volvulus 0.0537 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0218 0.285
Brugia malayi larval opioid receptor 0.0047 0.0012 0.0164
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.042 0.0265 0.0744
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1136 0.0748 1
Brugia malayi G protein-coupled receptor 0.0047 0.0012 0.0164
Loa Loa (eye worm) hypothetical protein 0.0474 0.0301 0.4025
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0226 0.0133 0.1713
Onchocerca volvulus 0.0047 0.0012 0.0363
Loa Loa (eye worm) hexokinase 0.0537 0.0344 0.4591
Brugia malayi G-protein coupled receptor 0.0047 0.0012 0.0164
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0012 0.016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.014 0.1803
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1136 0.0748 0.2137
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0474 0.0301 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1136 0.0748 0.0748
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.063 0.0406 0.5322
Loa Loa (eye worm) hypothetical protein 0.07 0.0453 0.6061
Onchocerca volvulus 0.0537 0.0344 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0769 0.05 0.6688
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.063 0.0406 0.1152
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0226 0.0133 0.0366
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0038 0.0007 0.0579
Schistosoma mansoni opsin-like receptor 0.0047 0.0012 0.016
Trypanosoma brucei cytochrome P450, putative 0.0058 0.002 0.0184
Entamoeba histolytica hypothetical protein 0.0226 0.0133 0.1713
Onchocerca volvulus 0.0047 0.0012 0.0363
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0012 0.0167
Toxoplasma gondii non-specific serine/threonine protein kinase 0.07 0.0453 0.6124
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.002 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0012 0.0012
Plasmodium vivax hexokinase, putative 0.0537 0.0344 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0012 0.0012
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0226 0.0133 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.1116 0.0735 0.9819
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0006 0.0083
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0012 0.0012
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Onchocerca volvulus 0.0047 0.0012 0.0363
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1158 0.0763 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1104 0.0726 0.9705
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0038 0.0007 0.0579
Trypanosoma brucei hexokinase, putative 0.0537 0.0344 0.4546
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.0406 0.539
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0038 0.0007 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Onchocerca volvulus 0.0226 0.0133 0.3881
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0001 0.0015
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0012 0.0164
Giardia lamblia Hypothetical protein 0.0226 0.0133 0.1713
Onchocerca volvulus 0.0047 0.0012 0.0363
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0281 0.0171 0.2297
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0012 0.0011
Echinococcus multilocularis somatostatin receptor 0.0047 0.0012 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0038 0.0007 0.0062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0012 0.0011
Onchocerca volvulus 0.0047 0.0012 0.0363
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0012 0.0011
Schistosoma mansoni neuropeptide receptor 0.1187 0.0782 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0351 0.0218 0.285
Brugia malayi ORL1-like opioid receptor 0.0047 0.0012 0.0164
Brugia malayi Dopamine receptor protein 1 0.0047 0.0012 0.0164
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0012 0.016
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1158 0.0763 0.9755
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0012 0.0164
Plasmodium vivax hypothetical protein, conserved 0.0226 0.0133 0.386
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0012 0.0012
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0012 0.0167
Schistosoma mansoni adenoreceptor 0.0047 0.0012 0.016
Brugia malayi Serotonin receptor 0.0047 0.0012 0.0164
Echinococcus multilocularis 0.0226 0.0133 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0012 0.0011
Onchocerca volvulus 0.0047 0.0012 0.0363
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0038 0.0007 0.0062
Brugia malayi Pre-SET motif family protein 0.0204 0.0119 0.1559
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0187 0.0107 0.1406
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0281 0.0171 0.017
Echinococcus granulosus somatostatin receptor 0.0047 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1136 0.0748 1
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0012 0.0012
Brugia malayi Hexokinase family protein 0.0537 0.0344 0.4501
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1115 0.0734 0.2008
Brugia malayi hypothetical protein 0.0047 0.0012 0.0164
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0038 0.0007 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.1126 0.0741 0.9909
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1124 0.074 0.9886
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0012 0.016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0226 0.0133 0.1747
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.07 0.0453 0.6028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0641 0.0414 0.5496
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0012 0.0011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0012 0.0012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.