TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 461.505 | Formula: C24H31NO8
H donors: 1 H acceptors: 4 LogP: 2 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@@H]1C[C@H](OC(=O)[C@@H](N)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1
InChi: 1S/C24H31NO8/c1-12(25)20(27)32-16-9-15(21(28)30-4)23(2)7-5-14-22(29)33-17(13-6-8-31-11-13)10-24(14,3)19(23)18(16)26/h6,8,11-12,14-17,19H,5,7,9-10,25H2,1-4H3/t12-,14-,15-,16-,17-,19-,23-,24-/m0/s1
InChiKey: UCEVLQJFQXOAPM-BAHRQEGZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	opioid receptor, mu 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, kappa 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Brugia malayi	Dopamine receptor protein 1	0.0127	0.0464	0.0947
Schistosoma mansoni	serine/threonine protein kinase	0.1267	0.4894	0.7692
Echinococcus multilocularis	neuroglian	0.0009	0.0005	0.0005
Brugia malayi	MH2 domain containing protein	0.0009	0.0003	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0135	0.0277
Brugia malayi	follicle stimulating hormone receptor	0.0127	0.0464	0.0947
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0127	0.0464	0.0724
Echinococcus multilocularis	transient receptor potential cation channel	0.0014	0.0025	0.0025
Schistosoma mansoni	neuropeptide receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0172	0.0351
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0127	0.0464	0.0464
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Echinococcus granulosus	neuropeptides capa receptor	0.0127	0.0464	0.0464
Schistosoma mansoni	transient receptor potential channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0003	0.0006
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0014	0.0025	0.0025
Echinococcus granulosus	neuroglian	0.0009	0.0005	0.0005
Echinococcus multilocularis	serotonin receptor	0.0367	0.1394	0.1394
Echinococcus multilocularis	hemicentin 1	0.0009	0.0005	0.0005
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.003	0.003
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0043	0.0135	0.0208
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0014	0.0025	0.0051
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0127	0.0464	0.0464
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0009	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.001	0.0009	0.0009
Echinococcus granulosus	7tm_1 domain containing protein	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	roundabout 2	0.0009	0.0005	0.0005
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0014	0.0025	0.0032
Schistosoma mansoni	myosin xvIII	0.0127	0.0464	0.0724
Schistosoma mansoni	tyrosine kinase	0.0013	0.002	0.0027
Onchocerca volvulus		0.0127	0.0464	0.0938
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0135	0.0277
Echinococcus granulosus	fmrfamide receptor	0.0127	0.0464	0.0464
Echinococcus multilocularis	two pore calcium channel protein 1	0.0014	0.0025	0.0025
Echinococcus granulosus	neuropeptide Y receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0016	0.0031	0.0062
Echinococcus granulosus	hypothetical protein	0.0127	0.0464	0.0464
Schistosoma mansoni	cell adhesion molecule	0.0048	0.0156	0.024
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	cytochrome P450	0.0051	0.0168	0.0343
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0127	0.0464	0.0947
Onchocerca volvulus		0.0127	0.0464	0.0938
Schistosoma mansoni	opsin-like receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0135	0.0277
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0528	0.2019	0.4126
Brugia malayi	G protein-coupled receptor	0.0127	0.0464	0.0947
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Echinococcus multilocularis	neuropeptides capa receptor	0.0127	0.0464	0.0464
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0802	0.3086	0.3086
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0051	0.0168	0.4356
Loa Loa (eye worm)	neuropeptide F receptor	0.0127	0.0464	0.0947
Brugia malayi	serine/threonine kinase 12	0.0104	0.0373	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	shaker cognate	0.0014	0.0025	0.0025
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0014	0.0025	0.0025
Brugia malayi	RNA binding protein	0.0135	0.0495	0.1011
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0014	0.0025	0.0025
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0127	0.0464	0.0947
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0051	0.0168	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0086	0.0086
Brugia malayi	ORL1-like opioid receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.029	0.1097	0.2242
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0009	0.0005	0.0003
Echinococcus multilocularis	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Toxoplasma gondii	hypothetical protein	0.0014	0.0025	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0135	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0051	0.0168	0.0816
Schistosoma mansoni	cpg binding protein	0.003	0.0086	0.0129
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.003	0.0061
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0014	0.0025	0.0025
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0127	0.0464	0.0464
Echinococcus granulosus	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Brugia malayi	sulfakinin receptor protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	potassium large conductance calcium activated	0.0014	0.0025	0.0025
Echinococcus granulosus	7TM GPCR rhodopsin	0.0127	0.0464	0.0464
Trypanosoma cruzi	cytochrome P450, putative	0.0077	0.0266	0.0526
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0051	0.0168	0.0816
Brugia malayi	MH1 domain containing protein	0.0009	0.0003	0.0007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0051	0.0168	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0528	0.2019	0.4126
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0014	0.0025	0.0051
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0005	0.0005
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0014	0.0025	0.0025
Brugia malayi	putative neuropeptide receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0135	0.0277
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0127	0.0464	0.0938
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0154	0.0154
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0014	0.0025	0.0025
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0127	0.0464	0.0724
Echinococcus granulosus	transient receptor potential cation channel	0.0014	0.0025	0.0025
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0009	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0003	0.0007
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0051	0.0168	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.003	0.003
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0014	0.0025	0.0051
Echinococcus granulosus	expressed protein	0.0009	0.0003	0.0003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0868	0.334	0.5248
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0014	0.0025	0.0051
Brugia malayi	cation channel family protein	0.0014	0.0025	0.0051
Echinococcus granulosus	dnaJ subfamily B	0.0405	0.1541	0.1541
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0373	0.0581
Brugia malayi	Dopamine receptor protein 2	0.0127	0.0464	0.0947
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0014	0.0025	0.0032
Echinococcus multilocularis	dnaJ subfamily B	0.0405	0.1541	0.1541
Schistosoma mansoni	vesicular amine transporter	0.0057	0.0191	0.0296
Loa Loa (eye worm)	CAMK protein kinase	0.0011	0.001	0.0021
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0051	0.0168	0.0816
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0014	0.0025	0.0051
Echinococcus multilocularis	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0014	0.0025	0.0025
Schistosoma mansoni	opsin-like receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Echinococcus multilocularis	neuroglian	0.0047	0.0151	0.0151
Loa Loa (eye worm)	AUR protein kinase	0.0104	0.0373	0.0762
Brugia malayi	serine/threonine-protein kinase plk-2	0.1267	0.4894	1
Toxoplasma gondii	aurora kinase	0.0104	0.0373	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0161	0.033
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0014	0.0025	0.0032
Echinococcus multilocularis	lachesin	0.0009	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0051	0.0168	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.2581	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0051	0.0168	0.0324
Onchocerca volvulus		0.0028	0.0079	0.0152
Loa Loa (eye worm)	RNA binding protein	0.0135	0.0495	0.1011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Echinococcus multilocularis	expressed protein	0.0009	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.0061
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0104	0.0373	0.0373
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0154	0.0238
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0011	0.001	0.0021
Echinococcus multilocularis	G protein coupled receptor 139	0.0127	0.0464	0.0464
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0014	0.0025	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0127	0.0464	0.0464
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	TAR-binding protein	0.0135	0.0495	0.1011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0161	0.033
Loa Loa (eye worm)	hypothetical protein	0.0528	0.2019	0.4126
Echinococcus granulosus	voltage gated potassium channel	0.0014	0.0025	0.0025
Schistosoma mansoni	nephrin	0.0047	0.0151	0.0233
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0752	0.2892	0.2892
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0014	0.0025	0.0034
Echinococcus granulosus	smad	0.0009	0.0003	0.0003
Echinococcus multilocularis	allatostatin A receptor	0.0127	0.0464	0.0464
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Echinococcus granulosus	transient receptor potential cation channel	0.0014	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0405	0.1541	0.2419
Schistosoma mansoni	nephrin	0.0009	0.0005	0.0003
Echinococcus granulosus	somatostatin receptor	0.0127	0.0464	0.0464
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0003	0.0003
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0127	0.0464	0.0464
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0051	0.0168	0.0816
Schistosoma mansoni	hypothetical protein	0.0034	0.0101	0.0153
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Schistosoma mansoni	60S ribosomal protein L21	0.0014	0.0025	0.0034
Loa Loa (eye worm)	neuropeptide F receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0172	0.0351
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0135	0.0277
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0014	0.0025	0.0034
Echinococcus multilocularis	neuropeptide receptor A26	0.0127	0.0464	0.0464
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0127	0.0464	0.0464
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0127	0.0464	0.0724
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0051	0.0168	0.0816
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0009	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	neuropeptide receptor	0.0127	0.0464	0.0724
Echinococcus granulosus	two pore calcium channel protein 1	0.0014	0.0025	0.0025
Entamoeba histolytica	serine/threonine protein kinase, putative	0.1267	0.4894	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0154	0.0154
Schistosoma mansoni	neuropeptide F-like receptor	0.0127	0.0464	0.0724
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus granulosus	tm gpcr rhodopsin	0.0752	0.2892	0.2892
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0014	0.0025	0.0051
Brugia malayi	neuropeptide F receptor	0.0127	0.0464	0.0947
Echinococcus granulosus	shaker cognate	0.0014	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0014	0.0025	0.0034
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0051	0.0168	1
Brugia malayi	Dopamine receptor	0.0127	0.0464	0.0947
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0104	0.0373	0.0744
Echinococcus granulosus	cpg binding protein	0.003	0.0086	0.0086
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0104	0.0373	1
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0077	0.0266	0.1305
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0127	0.0464	0.0464
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0014	0.0025	0.0034
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	transient receptor potential cation channel	0.0015	0.0026	0.0026
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.1267	0.4894	0.4894
Echinococcus granulosus	G protein coupled receptor 139	0.0127	0.0464	0.0464
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0051	0.0168	0.0816
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.001	0.0009	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0127	0.0464	0.0724
Echinococcus multilocularis	voltage gated potassium channel	0.0014	0.0025	0.0025
Loa Loa (eye worm)	CYP4Cod1	0.0077	0.0266	0.0544
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0051	0.0168	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0203	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	transient receptor potential gamma protein	0.0014	0.0025	0.0025
Brugia malayi	Smad1	0.0009	0.0003	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0161	0.033
Echinococcus multilocularis	transient receptor potential cation channel	0.0014	0.0025	0.0025
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0051	0.0168	0.0816
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0079	0.0162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0154	0.0238
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0014	0.0025	0.0034
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0014	0.0025	0.0051
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0495	0.0773
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0003	0.0003
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0014	0.0025	0.0034
Schistosoma mansoni	voltage-gated ion channel	0.0014	0.0025	0.0034
Schistosoma mansoni	ryanodine receptor related	0.0014	0.0025	0.0034
Schistosoma mansoni	titin	0.0011	0.001	0.0011
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0051	0.0168	0.0324
Brugia malayi	MH1 domain containing protein	0.0009	0.0003	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0014	0.0025	0.0034
Echinococcus granulosus	potassium large conductance calcium activated	0.0014	0.0025	0.0025
Loa Loa (eye worm)	ion channel NompC	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0135	0.0495	0.1011
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0014	0.0025	0.0034
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0127	0.0464	0.0938
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Trypanosoma brucei	cytochrome P450, putative	0.0077	0.0266	0.0526
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.1267	0.4894	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0127	0.0464	0.0464
Schistosoma mansoni	titin	0.0009	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Schistosoma mansoni	transient receptor potential channel	0.0015	0.0026	0.0036
Echinococcus multilocularis	ryanodine receptor 44f	0.0014	0.0025	0.0025
Echinococcus granulosus	titin	0.0011	0.001	0.001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0161	0.033
Echinococcus multilocularis	g protein coupled receptor	0.0127	0.0464	0.0464
Echinococcus multilocularis	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0051	0.0168	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus multilocularis	sodium leak channel non selective protein	0.0014	0.0025	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0127	0.0464	0.0464
Schistosoma mansoni	neuroglian	0.0009	0.0005	0.0003
Brugia malayi	putative neuropeptide receptor NPR1	0.0127	0.0464	0.0947
Toxoplasma gondii	transporter, cation channel family protein	0.0014	0.0025	0.0427
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0014	0.0025	0.004
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	hypothetical protein	0.0014	0.0025	0.0025
Echinococcus multilocularis	twitchin	0.0011	0.001	0.001
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0014	0.0025	0.0025
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0003	0.0003
Brugia malayi	MH2 domain containing protein	0.013	0.0476	0.0972
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0104	0.0373	0.5
Loa Loa (eye worm)	voltage-gated potassium channel	0.0014	0.0025	0.0051
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0373	0.0756
Brugia malayi	G-protein coupled receptor	0.0127	0.0464	0.0947
Toxoplasma gondii	transporter, cation channel family protein	0.0014	0.0025	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0101	0.0205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Onchocerca volvulus		0.0528	0.2019	0.412
Brugia malayi	neuropeptide F receptor	0.0127	0.0464	0.0947
Schistosoma mansoni	biogenic amine receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	Cytochrome P450 family protein	0.0182	0.0676	0.1381
Echinococcus granulosus	tyrosine protein kinase Lyn	0.001	0.0009	0.0009
Echinococcus granulosus	neuropeptide receptor	0.0127	0.0464	0.0464
Schistosoma mansoni	hypothetical protein	0.0127	0.0464	0.0724
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0127	0.0464	0.0724
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.1267	0.4894	0.4894
Trichomonas vaginalis	CAMK family protein kinase	0.0454	0.1733	0.3537
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0014	0.0025	0.0025
Echinococcus granulosus	defective proboscis extension response	0.0043	0.0135	0.0135
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0127	0.0464	0.0947
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0014	0.0025	0.0034
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0127	0.0464	0.0464
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0005	0.0005
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0051	0.0168	1
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0051	0.0168	0.0816
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0051	0.0168	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0127	0.0464	0.0724
Echinococcus granulosus	hyperpolarization activated cyclic	0.0014	0.0025	0.0025
Onchocerca volvulus	Tyrosine kinase homolog	0.0246	0.0926	0.1884
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.001	0.0011
Echinococcus multilocularis	titin	0.0011	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0127	0.0464	0.0724
Echinococcus multilocularis	smad	0.0009	0.0003	0.0003
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.003	0.003
Echinococcus granulosus	tyrosine protein kinase otk	0.0009	0.0005	0.0005
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0009	0.0005	0.0011
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0495	0.0773
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0127	0.0464	0.0947
Echinococcus granulosus	activin receptor type	0.001	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0051	0.0168	0.0816
Schistosoma mansoni	amine GPCR	0.0127	0.0464	0.0724
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0003	0.5
Brugia malayi	Melatonin receptor type 1A	0.0127	0.0464	0.0947
Echinococcus multilocularis	neuropeptide receptor	0.0127	0.0464	0.0464
Brugia malayi	RNA recognition motif domain containing protein	0.0135	0.0495	0.1011
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0495	0.0773
Echinococcus granulosus	transient receptor potential cation channel	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1394	0.2849
Echinococcus multilocularis	sodium channel protein	0.0014	0.0025	0.0025
Schistosoma mansoni	biogenic amine receptor	0.0127	0.0464	0.0724
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.0042
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0014	0.0025	0.0025
Onchocerca volvulus		0.0238	0.0895	0.182
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0127	0.0464	0.0947
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0014	0.0025	0.0051
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0014	0.0025	0.0034
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0104	0.0373	0.0744
Schistosoma mansoni	hypothetical protein	0.0127	0.0464	0.0724
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0014	0.0025	0.0034
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0127	0.0464	0.0724
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0495	0.0773
Loa Loa (eye worm)	cytochrome P450	0.0051	0.0168	0.0343
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0051	0.0168	0.0816
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus multilocularis	transient receptor potential gamma protein	0.0014	0.0025	0.0025
Echinococcus multilocularis	sex peptide receptor	0.0127	0.0464	0.0464
Onchocerca volvulus		0.0127	0.0464	0.0938
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.0042
Echinococcus granulosus	sodium channel protein	0.0014	0.0025	0.0025
Schistosoma mansoni	roundabout	0.0009	0.0005	0.0003
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0127	0.0464	0.0724
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0528	0.2019	0.317
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0051	0.0168	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0014	0.0025	0.0034
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.1267	0.4894	1
Echinococcus multilocularis		0.0051	0.0168	0.0168
Leishmania major	cytochrome p450-like protein	0.0077	0.0266	0.0526
Onchocerca volvulus		0.0127	0.0464	0.0938
Schistosoma mansoni	amine GPCR	0.0127	0.0464	0.0724
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Brugia malayi	ion channel NompC	0.0014	0.0025	0.0051
Brugia malayi	cation channel family protein	0.0014	0.0025	0.0051
Echinococcus granulosus	voltage gated potassium channel	0.0014	0.0025	0.0025
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Echinococcus granulosus	serotonin receptor	0.0127	0.0464	0.0464
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0051	0.0168	0.0324
Echinococcus granulosus	allatostatin A receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0127	0.0464	0.0464
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0014	0.0025	0.0025
Echinococcus multilocularis	transient receptor potential cation channel	0.0014	0.0025	0.0025
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0014	0.0025	0.0025
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0051	0.0168	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0168	0.0259
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0051	0.0168	1
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0174	0.0645	0.1319
Echinococcus multilocularis	fmrfamide receptor	0.0127	0.0464	0.0464
Echinococcus granulosus	translocator protein	0.0528	0.2019	0.2019
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Brugia malayi	hypothetical protein	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	calcium channel	0.0014	0.0025	0.0051
Schistosoma mansoni	calcium-activated potassium channel	0.0014	0.0025	0.0034
Echinococcus granulosus	aurora kinase A	0.0104	0.0373	0.0373
Echinococcus multilocularis	transient receptor potential cation channel	0.0014	0.0025	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Schistosoma mansoni	growth hormone secretagogue receptor	0.0127	0.0464	0.0724
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	protein kinase	0.001	0.0009	0.001
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0051	0.0168	0.0816
Schistosoma mansoni	neuropeptide f receptor 76f	0.0127	0.0464	0.0724
Echinococcus granulosus	hyperpolarization activated cyclic	0.0014	0.0025	0.0025
Onchocerca volvulus		0.0127	0.0464	0.0938
Brugia malayi	Transient-receptor-potential like protein	0.0014	0.0025	0.0051
Echinococcus multilocularis	orexin receptor type 2	0.0127	0.0464	0.0464
Loa Loa (eye worm)	Smad1	0.0009	0.0003	0.0007
Brugia malayi	TspO/MBR family protein	0.0528	0.2019	0.4126
Brugia malayi	serine/threonine protein kinase 6	0.0104	0.0373	0.0762
Echinococcus granulosus	GPCR family 2	0.0016	0.003	0.003
Echinococcus granulosus	sodium leak channel non selective protein	0.0014	0.0025	0.0025
Echinococcus granulosus	short transient receptor potential channel 6	0.0015	0.0026	0.0026
Onchocerca volvulus		0.0127	0.0464	0.0938
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0014	0.0025	0.0051
Schistosoma mansoni	amine GPCR	0.0127	0.0464	0.0724
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0051	0.0168	1
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0014	0.0025	0.0051
Schistosoma mansoni	septate junction protein	0.0009	0.0005	0.0003
Echinococcus granulosus	sex peptide receptor	0.0127	0.0464	0.0464
Leishmania major	cytochrome p450-like protein	0.0051	0.0168	0.0324
Echinococcus granulosus	contactin	0.0009	0.0005	0.0005
Schistosoma mansoni	neuropeptide receptor	0.0127	0.0464	0.0724
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Schistosoma mansoni	hypothetical protein	0.0127	0.0464	0.0724
Echinococcus multilocularis	Immunoglobulin	0.0043	0.0135	0.0135
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0154	0.0315
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0051	0.0168	0.0816
Schistosoma mansoni	kinase	0.1645	0.6362	1
Echinococcus multilocularis	ferritin	0.0009	0.0003	0.0003
Brugia malayi	Prion-like-	0.0009	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0014	0.0025	0.004
Echinococcus multilocularis	Immunoglobulin	0.0043	0.0135	0.0135
Echinococcus granulosus	hemicentin 1	0.0009	0.0005	0.0005
Echinococcus multilocularis	roundabout 2	0.0009	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	hypothetical protein	0.0213	0.0797	0.1628
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.003	0.0061
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0014	0.0025	0.0025
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0005	0.0003
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0014	0.0025	0.0051
Schistosoma mansoni	adenoreceptor	0.0127	0.0464	0.0724
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Brugia malayi	Serotonin receptor	0.0127	0.0464	0.0947
Echinococcus granulosus	cytochrome P450 2K1	0.0051	0.0168	0.0168
Echinococcus multilocularis	tumor protein p63	0.0336	0.1274	0.1274
Echinococcus granulosus	transient receptor potential cation channel	0.0015	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0014	0.0025	0.0034
Schistosoma mansoni	neuropeptide F-like receptor	0.0127	0.0464	0.0724
Loa Loa (eye worm)	G-protein coupled receptor	0.0127	0.0464	0.0947
Echinococcus multilocularis	tar DNA binding protein	0.0135	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	neuroglian	0.0047	0.0151	0.0151
Schistosoma mansoni	two-pore calcium channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.0645	0.101
Echinococcus granulosus	neuropeptide receptor A26	0.0127	0.0464	0.0464
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0051	0.0168	0.0816
Echinococcus multilocularis	transient receptor potential cation channel	0.0015	0.0026	0.0026
Echinococcus granulosus	Immunoglobulin	0.0043	0.0135	0.0135
Echinococcus granulosus	tumor protein p63	0.0336	0.1274	0.1274
Brugia malayi	olfactory channel protein osm-9	0.0015	0.0026	0.0053
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.0042
Echinococcus granulosus	neuropeptides capa receptor	0.0127	0.0464	0.0464
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Echinococcus granulosus	biogenic amine 5HT receptor	0.0868	0.334	0.334
Echinococcus multilocularis	short transient receptor potential channel 6	0.0014	0.0025	0.0025
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0048	0.0156	0.0156
Echinococcus granulosus	calcium activated potassium channel	0.0021	0.005	0.005
Schistosoma mansoni	neuropeptide receptor	0.0127	0.0464	0.0724
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0003	0.0003
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0127	0.0464	0.0724
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0014	0.0025	0.0025
Loa Loa (eye worm)	AUR protein kinase	0.0104	0.0373	0.0762
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0832	0.3201	0.3201
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0014	0.0025	0.0051
Echinococcus multilocularis	calcium activated potassium channel	0.0021	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0051	0.0168	0.0324
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0127	0.0464	0.0724
Schistosoma mansoni	opsin-like receptor	0.0127	0.0464	0.0724
Echinococcus granulosus	g protein coupled receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	G protein-coupled receptor F59B2.13	0.0127	0.0464	0.0947
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0051	0.0168	1
Brugia malayi	Fibronectin type III domain containing protein	0.0043	0.0135	0.0277
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0127	0.0464	0.0464
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0127	0.0464	0.0947
Echinococcus granulosus	dro:myosuppressin receptor	0.0127	0.0464	0.0464
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0104	0.0373	0.0373
Schistosoma mansoni	biogenic amine receptor	0.0127	0.0464	0.0724
Echinococcus multilocularis	neuropeptide Y receptor	0.0127	0.0464	0.0464
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0003	0.0003
Brugia malayi	G-protein coupled receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0003	0.0003
Trypanosoma cruzi	aurora B kinase, putative	0.0104	0.0373	0.0744
Loa Loa (eye worm)	ryanodine receptor	0.0014	0.0025	0.0051
Echinococcus multilocularis	g-protein coupled receptor	0.0127	0.0464	0.0464
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0051	0.0168	0.0816
Brugia malayi	Serotonin receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0014	0.0025	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0495	0.0773
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0127	0.0464	0.0464
Echinococcus granulosus	Smad4	0.0009	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Giardia lamblia	Kinase, PLK	0.1267	0.4894	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0043	0.0135	0.0208
Entamoeba histolytica	protein kinase, putative	0.0104	0.0373	0.0744
Echinococcus multilocularis	translocator protein	0.0528	0.2019	0.2019
Echinococcus granulosus	peroxidasin	0.0009	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	hypothetical protein	0.0043	0.0135	0.0277
Echinococcus granulosus	two pore calcium channel protein 2	0.0014	0.0025	0.0025
Echinococcus multilocularis	roundabout 2	0.0009	0.0005	0.0005
Echinococcus granulosus	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0051	0.0168	1
Trichomonas vaginalis	CAMK family protein kinase	0.0454	0.1733	0.3537
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0154	0.0315
Echinococcus multilocularis	roundabout 2	0.0052	0.0172	0.0172
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0043	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus multilocularis	Smad4	0.0009	0.0003	0.0003
Echinococcus multilocularis	neuropeptide receptor	0.0127	0.0464	0.0464
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Echinococcus granulosus	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0014	0.0025	0.0051
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0178	0.464
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	conserved hypothetical protein	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0154	0.0154
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0014	0.0025	0.0025
Trypanosoma cruzi	cytochrome P450, putative	0.0077	0.0266	0.0526
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0014	0.0025	0.0051
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0168	0.0343
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0014	0.0025	0.0025
Onchocerca volvulus	Serine\/threonine kinase homolog	0.1267	0.4894	1
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0127	0.0464	0.0464
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0101	0.0205
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0154	0.0154
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0154	0.0238
Onchocerca volvulus		0.0528	0.2019	0.412
Leishmania major	cytochrome p450-like protein	0.0051	0.0168	0.0324
Onchocerca volvulus		0.0011	0.001	0.001
Schistosoma mansoni	cpg binding protein	0.003	0.0086	0.0129
Echinococcus multilocularis	neuropeptide Y receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0127	0.0464	0.0947
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.0476	0.0972
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0014	0.0025	0.0025
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.001	0.0021
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0014	0.0025	0.0051
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0043	0.0135	0.0277
Schistosoma mansoni	amine GPCR	0.0127	0.0464	0.0724
Echinococcus granulosus	g protein coupled receptor	0.0127	0.0464	0.0464
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Echinococcus granulosus	neuropeptide Y receptor	0.0127	0.0464	0.0464
Brugia malayi	MH2 domain containing protein	0.0009	0.0003	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0127	0.0464	0.0464
Echinococcus granulosus	neuropeptide FF receptor 2	0.0127	0.0464	0.0464
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0003	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.0476	0.0972
Echinococcus granulosus	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Onchocerca volvulus		0.0528	0.2019	0.412
Schistosoma mansoni	amine GPCR	0.0127	0.0464	0.0724
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0014	0.0025	0.0034
Loa Loa (eye worm)	G-protein coupled receptor	0.0127	0.0464	0.0947
Echinococcus multilocularis	fmrfamide receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	AUR protein kinase	0.0104	0.0373	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0005	0.0005
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Toxoplasma gondii	transporter, cation channel family protein	0.0014	0.0025	0.0427
Entamoeba histolytica	protein kinase domain containing protein	0.0104	0.0373	0.0744
Schistosoma mansoni	cytochrome P450	0.0051	0.0168	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	larval opioid receptor	0.0127	0.0464	0.0947
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0051	0.0168	0.0816
Echinococcus multilocularis	peroxidasin	0.0009	0.0005	0.0005
Echinococcus multilocularis	GPCR, family 2	0.0016	0.003	0.003
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0025	0.0427
Entamoeba histolytica	protein kinase, putative	0.0104	0.0373	0.0744
Schistosoma mansoni	histamine h1 receptor	0.0127	0.0464	0.0724
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	neuropeptide receptor	0.0127	0.0464	0.0464
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0025	0.0427
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Brugia malayi	Protein kinase domain containing protein	0.0174	0.0645	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	cytochrome P450 family protein	0.0077	0.0266	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0026	0.0053
Schistosoma mansoni	voltage-gated cation channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0127	0.0464	0.0464
Brugia malayi	protein unc-22	0.0011	0.001	0.0021
Echinococcus granulosus	transient receptor potential cation channel	0.0014	0.0025	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.001	0.0011
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0009	0.0005	0.0005
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0014	0.0025	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.003	0.0061
Echinococcus multilocularis	voltage gated potassium channel	0.0014	0.0025	0.0025
Brugia malayi	Cytochrome P450 family protein	0.0077	0.0266	0.0544
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0127	0.0464	0.0464
Brugia malayi	AKH receptor	0.0127	0.0464	0.0947
Echinococcus granulosus	transient receptor potential cation channel	0.0014	0.0025	0.0025
Echinococcus multilocularis	voltage dependent calcium channel	0.0014	0.0025	0.0025
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0014	0.0025	0.0025
Echinococcus granulosus	g protein coupled receptor	0.0127	0.0464	0.0464
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0868	0.334	0.334
Trichomonas vaginalis	CAMK family protein kinase	0.1267	0.4894	1
Schistosoma mansoni	protein kinase	0.0104	0.0373	0.0581
Echinococcus multilocularis	transfer RNA-Gly	0.0014	0.0025	0.0025
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0127	0.0464	0.0464
Echinococcus granulosus	roundabout 2	0.0009	0.0005	0.0005
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0005	0.0003
Echinococcus multilocularis	potassium voltage gated channel protein	0.0014	0.0025	0.0025
Trypanosoma brucei	polo-like protein kinase	0.1267	0.4894	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0156	0.0318
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0014	0.0025	0.0025
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0014	0.0025	0.0025
Loa Loa (eye worm)	melatonin receptor type 1A	0.0127	0.0464	0.0947
Brugia malayi	voltage-dependent calcium channel	0.0014	0.0025	0.0051
Brugia malayi	GnHR receptor homolog	0.0127	0.0464	0.0947
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0127	0.0464	0.0724
Onchocerca volvulus		0.0127	0.0464	0.0938
Onchocerca volvulus		0.0528	0.2019	0.412
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus granulosus	roundabout 2	0.0052	0.0172	0.0172
Echinococcus granulosus	titin	0.0011	0.001	0.001
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0014	0.0025	0.0025
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0014	0.0025	0.0025
Echinococcus granulosus	neuropeptide s receptor	0.0127	0.0464	0.0464
Treponema pallidum	bacterioferrin (TpF1)	0.0009	0.0003	0.5
Trypanosoma brucei	aurora B kinase	0.0104	0.0373	0.0744
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0051	0.0168	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.1267	0.4894	1
Onchocerca volvulus		0.0014	0.0025	0.004
Echinococcus granulosus	short transient receptor potential channel 6	0.0014	0.0025	0.0025
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0014	0.0025	0.0025
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0014	0.0025	0.0044
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0367	0.1394	0.2188
Echinococcus granulosus	lachesin	0.0009	0.0005	0.0005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0127	0.0464	0.0724
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Echinococcus multilocularis	serotonin receptor	0.0367	0.1394	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0373	0.0756
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0104	0.0373	0.0744
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0014	0.0025	0.0051
Echinococcus granulosus	biogenic amine 5HT receptor	0.0367	0.1394	0.1394
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0051	0.0168	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0528	0.2019	0.4126
Schistosoma mansoni	cpg binding protein	0.0028	0.0079	0.012
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	neuropeptide s receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	voltage-gated potassium channel	0.0014	0.0025	0.0051
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0127	0.0464	0.0947
Schistosoma mansoni	transient receptor potential channel 4	0.0014	0.0025	0.0034
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0011
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus granulosus	tar DNA binding protein	0.0135	0.0495	0.0495
Entamoeba histolytica	protein kinase , putative	0.0104	0.0373	0.0744
Echinococcus granulosus	TRP transient receptor potential channel	0.0014	0.0025	0.0025
Leishmania major	hypothetical protein, unknown function	0.0014	0.0025	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.003	0.003
Loa Loa (eye worm)	cytochrome P450 family protein	0.0077	0.0266	0.0544
Schistosoma mansoni	voltage-dependent calcium channel	0.0014	0.0025	0.0034
Echinococcus multilocularis	activin receptor type	0.001	0.0009	0.0009
Echinococcus multilocularis	dro:myosuppressin receptor	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0049	0.016	0.0327
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0051	0.0168	1
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0373	0.0756
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0014	0.0025	0.0034
Echinococcus multilocularis	hemicentin 1	0.0009	0.0005	0.0005
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0005	0.0003
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus granulosus	ferritin	0.0009	0.0003	0.0003
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0014	0.0025	0.0025
Loa Loa (eye worm)	TYRA-2 protein	0.0127	0.0464	0.0947
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0014	0.0025	0.0025
Echinococcus multilocularis	two pore calcium channel protein 2	0.0014	0.0025	0.0025
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0127	0.0464	0.0724
Echinococcus granulosus	rhodopsin orphan GPCR	0.0127	0.0464	0.0464
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0014	0.0025	0.0025
Echinococcus granulosus	twitchin	0.0053	0.0177	0.0177
Onchocerca volvulus		0.0127	0.0464	0.0938
Echinococcus multilocularis	neuropeptides capa receptor	0.0127	0.0464	0.0464
Brugia malayi	Immunoglobulin I-set domain containing protein	0.029	0.1097	0.2242
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0014	0.0025	0.0025
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0079	0.0162
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0014	0.0025	0.0032
Schistosoma mansoni	transient receptor potential channel	0.0014	0.0025	0.0034
Echinococcus multilocularis	tyrosine protein kinase otk	0.0009	0.0005	0.0005
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0014	0.0025	0.0025
Echinococcus multilocularis	somatostatin receptor	0.0127	0.0464	0.0464
Toxoplasma gondii	hypothetical protein	0.0014	0.0025	0.0427
Onchocerca volvulus		0.0127	0.0464	0.0938
Brugia malayi	Cytochrome P450 family protein	0.0077	0.0266	0.0544
Echinococcus multilocularis	g protein coupled receptor	0.0127	0.0464	0.0464
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0014	0.0025	0.0034
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0051	0.0168	0.0816
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0068	0.0138
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0051	0.0168	1
Echinococcus multilocularis	aurora kinase A	0.0104	0.0373	0.0373
Loa Loa (eye worm)	cytochrome P450 family protein	0.0182	0.0676	0.1381
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0014	0.0025	0.0025
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0127	0.0464	0.0464
Echinococcus granulosus	voltage dependent calcium channel	0.0014	0.0025	0.0025
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0014	0.0025	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.0127	0.0464	0.0464
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0005	0.0003
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0528	0.2019	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0051	0.0168	1
Brugia malayi	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0014	0.0025	0.0025
Brugia malayi	Peroxidasin	0.0009	0.0005	0.0011
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0051	0.0168	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus multilocularis	short transient receptor potential channel 6	0.0015	0.0026	0.0026
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0051	0.0168	0.0816
Schistosoma mansoni	voltage-gated potassium channel	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0025	0.0051
Echinococcus multilocularis	voltage dependent calcium channel	0.0014	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0367	0.1394	0.2849
Leishmania major	hypothetical protein, conserved	0.0014	0.0025	0.0032
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0051	0.0168	1
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.016	0.0246
Mycobacterium leprae	putative cytochrome p450	0.0051	0.0168	1
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.0042
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0051	0.0168	0.0324
Echinococcus granulosus	ryanodine receptor 44f	0.0014	0.0025	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0373	0.0756
Trypanosoma cruzi	polo-like protein kinase, putative	0.1267	0.4894	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0005	0.0011
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0014	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	protein kinase	0.001	0.0009	0.001
Leishmania major	protein kinase, putative	0.0104	0.0373	0.0744
Schistosoma mansoni	protein kinase	0.001	0.0009	0.001
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0832	0.3201	0.3201
Onchocerca volvulus		0.0049	0.016	0.0316
Brugia malayi	RE15519p	0.0127	0.0464	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	g-protein coupled receptor	0.0127	0.0464	0.0464
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0014	0.0025	0.0051
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0014	0.0025	0.0025
Loa Loa (eye worm)	voltage-gated calcium channel	0.0014	0.0025	0.0051
Brugia malayi	TAR-binding protein	0.0135	0.0495	0.1011
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0051	0.0168	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0009	0.0005	0.0011
Mycobacterium leprae	Conserved hypothetical protein	0.0051	0.0168	1
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0014	0.0025	0.0032
Brugia malayi	serine/threonine-protein kinase 6	0.0104	0.0373	0.0762
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0014	0.0025	0.0051
Echinococcus granulosus	orexin receptor type 2	0.0127	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Schistosoma mansoni	septate junction protein	0.0009	0.0005	0.0003
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0014	0.0025	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0464	0.0947
Echinococcus granulosus	voltage dependent calcium channel	0.0014	0.0025	0.0025

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= -1.6 %	Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells relative to DAMGO	ChEMBL.	21115248
Activity (binding)	= 0 %	Displacement of [3H]diprenorphine from kappa opioid receptor expressed in HEK293 cells relative to salvinorin A	ChEMBL.	21115248
Activity (binding)	= 18 %	Displacement of [3H]DADLE from delta opioid receptor expressed in HEK293 cells relative to DADLE	ChEMBL.	21115248
Activity (binding)	= 82 %	Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells relative to salvinorin A	ChEMBL.	21115248
EC50 (functional)	nM	Effective concentration for activation of human Opioid receptor kappa 1 expressed in chinese hamster ovary cells to enhance [35S]-GTP-gammaS, binding; ND=Not determined	ChEMBL.	15869877
Efficacy (functional)	%	Activation of human Opioid receptor kappa 1 expressd in chinese hamster ovary cells to enhance [35S]-GTP-gammaS, binding compared to U50,488H; ND=Not determined	ChEMBL.	15869877
Ki (binding)	= 3784 nM	Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells	ChEMBL.	21115248
Ki (binding)	> 10000 nM	Inhibition of [3H]-diprenorphine binding to human Opioid receptor kappa 1 expressed in chinese hamster ovary cells	ChEMBL.	15869877
Ki (binding)	> 10000 nM	Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells	ChEMBL.	21115248
Ki (binding)	> 10000 nM	Displacement of [3H]DADLE from delta opioid receptor expressed in HEK293 cells	ChEMBL.	21115248

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1644773

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1464833