Detailed information for compound 1505379

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.297 | Formula: C19H22Cl2N2
  • H donors: 1 H acceptors: 1 LogP: 5.23 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)nc1c(c2N)C2CC(C1)C=C(C2)C(C)C.Cl
  • InChi: 1S/C19H21ClN2.ClH/c1-10(2)12-5-11-6-13(8-12)18-17(7-11)22-16-9-14(20)3-4-15(16)19(18)21;/h3-5,9-11,13H,6-8H2,1-2H3,(H2,21,22);1H
  • InChiKey: ZFQGNEPBYGEBMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 alpha 0.0177245 0.088708 0.0884913
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Echinococcus multilocularis tubulin alpha 3 chain 0.120024 0.74826 0.7482
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.00836093 0.0283384 0.0281074
Echinococcus granulosus tubulin beta 1 chain 0.15907 1 1
Trypanosoma brucei beta tubulin 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00544735 0.00955376 0.00955376
Echinococcus multilocularis tubulin alpha 3 chain 0.120024 0.74826 0.7482
Echinococcus multilocularis hypothetical protein 0.120024 0.74826 0.7482
Onchocerca volvulus Putative organic anion transporter 0.00619529 0.0143759 0.0492243
Echinococcus granulosus tyrosine protein kinase Lyn 0.00891427 0.0319059 0.0316757
Brugia malayi Thioredoxin reductase 0.0152268 0.0726043 0.0723838
Brugia malayi Protein kinase domain containing protein 0.0135521 0.0618072 0.0615841
Echinococcus granulosus peroxisome assembly protein 26 0.120024 0.74826 0.7482
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.00527653 0.00845244 0.00821668
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0177245 0.088708 0.0884913
Echinococcus granulosus integrin alpha 3 0.0146032 0.0685838 0.0683623
Loa Loa (eye worm) hypothetical protein 0.0151367 0.0720236 0.0720236
Echinococcus multilocularis Tubulin beta 2C chain 0.15907 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.00836093 0.0283384 0.0283384
Schistosoma mansoni tyrosine kinase 0.0135521 0.0618072 0.0618072
Loa Loa (eye worm) hypothetical protein 0.0320898 0.181325 0.181325
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0177245 0.088708 0.0884913
Echinococcus multilocularis beta tubulin 0.15907 1 1
Trypanosoma brucei tubulin delta chain 0.0871287 0.536175 0.532221
Loa Loa (eye worm) steroid hormone receptor 0.0177245 0.088708 0.088708
Echinococcus granulosus tubulin alpha 3 chain 0.120024 0.74826 0.7482
Loa Loa (eye worm) hypothetical protein 0.0163717 0.0799859 0.0799859
Echinococcus multilocularis Tubulin alpha 1 chain 0.120024 0.74826 0.7482
Echinococcus granulosus tubulin beta 4A class IVa 0.15907 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.15907 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.120024 0.74826 0.746114
Onchocerca volvulus Protein ultraspiracle homolog 0.0177245 0.088708 0.308023
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00891427 0.0319059 0.0316757
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00891427 0.0319059 0.0316757
Schistosoma mansoni tubulin subunit delta 0.0399299 0.231872 0.231872
Echinococcus granulosus tubulin alpha 1C chain 0.120024 0.74826 0.7482
Brugia malayi Nuclear hormone receptor E75 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) norepinephrine transporter 0.0320898 0.181325 0.181325
Echinococcus multilocularis peroxisome assembly protein 26 0.120024 0.74826 0.7482
Brugia malayi Protein kinase domain containing protein 0.00494079 0.00628783 0.00605156
Loa Loa (eye worm) TK protein kinase 0.0149732 0.0709692 0.0709692
Loa Loa (eye worm) hypothetical protein 0.0093636 0.0348029 0.0348029
Schistosoma mansoni tubulin subunit alpha 0.120024 0.74826 0.74826
Echinococcus granulosus tubulin subunit TubB 0.120024 0.74826 0.7482
Brugia malayi hypothetical protein 0.00528736 0.00852224 0.0082865
Brugia malayi ecdysteroid receptor 0.0177245 0.088708 0.0884913
Trichomonas vaginalis tubulin, putative 0.0477238 0.282121 0.276001
Leishmania major beta tubulin 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.00400239 0.00023771 0.00023771
Echinococcus multilocularis serotonin transporter 0.0320898 0.181325 0.18113
Loa Loa (eye worm) TK/ROR protein kinase 0.00402078 0.000356293 0.000356293
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0177245 0.088708 0.088708
Brugia malayi Nuclear hormone receptor-like 1 0.0177245 0.088708 0.0884913
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.00891427 0.0319059 0.0316757
Mycobacterium leprae cell division protein FtsZ 0.0399299 0.231872 1
Schistosoma mansoni nuclear receptor nhr-48 0.00836093 0.0283384 0.0283384
Entamoeba histolytica tubulin alpha chain, putative 0.120024 0.74826 0.746667
Loa Loa (eye worm) kelch domain-containing protein family protein 0.00528736 0.00852224 0.00852224
Echinococcus granulosus Tubulin beta 2C chain 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Brugia malayi Tubulin alpha chain 0.0399299 0.231872 0.231689
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.00527653 0.00845244 0.00821668
Trichomonas vaginalis tubulin epsilon chain, putative 0.120024 0.74826 0.746114
Loa Loa (eye worm) tubulin alpha 2 0.0800941 0.490821 0.490821
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00544735 0.00955376 0.00955376
Brugia malayi nuclear receptor RXR 0.0093636 0.0348029 0.0345734
Trichomonas vaginalis tubulin alpha chain, putative 0.15907 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049633 0.00643297 0.00643297
Schistosoma mansoni ephrin receptor 0.00401024 0.000288331 0.000288331
Treponema pallidum sodium- and chloride- dependent transporter 0.0320898 0.181325 0.773757
Loa Loa (eye worm) hypothetical protein 0.0128508 0.0572857 0.0572857
Echinococcus multilocularis Tubulin alpha 1 chain 0.120024 0.74826 0.7482
Brugia malayi Immunoglobulin I-set domain containing protein 0.00635363 0.0153968 0.0151627
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Echinococcus granulosus tyrosine protein kinase Fyn 0.00891427 0.0319059 0.0316757
Trichomonas vaginalis tubulin gamma chain, putative 0.0961493 0.594333 0.590875
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0278565 0.154032 0.153831
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00931827
Onchocerca volvulus 0.00619529 0.0143759 0.0492243
Loa Loa (eye worm) hypothetical protein 0.0714725 0.435236 0.435236
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0146432 0.0688417 0.0686203
Leishmania major beta tubulin 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Loa Loa (eye worm) hypothetical protein 0.00400239 0.00023771 0.00023771
Echinococcus multilocularis tubulin subunit beta 0.15907 1 1
Schistosoma mansoni nuclear hormone receptor 0.00836093 0.0283384 0.0283384
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00544735 0.00955376 0.00955376
Schistosoma mansoni tyrosine kinase 0.0135521 0.0618072 0.0618072
Echinococcus multilocularis tubulin beta 1 chain 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Brugia malayi nuclear receptor NHR-88 0.00836093 0.0283384 0.0281074
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi nuclear hormone receptor 0.00836093 0.0283384 0.0281074
Toxoplasma gondii hypothetical protein 0.00544735 0.00955376 0.00931827
Trypanosoma brucei alpha tubulin 0.120024 0.74826 0.746114
Brugia malayi SH2 domain containing protein 0.00494079 0.00628783 0.00605156
Trichomonas vaginalis tubulin epsilon chain, putative 0.0399299 0.231872 0.225324
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Onchocerca volvulus 0.00544735 0.00955376 0.0324353
Schistosoma mansoni tubulin subunit beta 0.15907 1 1
Schistosoma mansoni tyrosine kinase 0.0167024 0.0821178 0.0821178
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00544735 0.00955376 0.00931827
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00544735 0.00955376 0.00955376
Giardia lamblia Alpha-tubulin 0.120024 0.74826 0.746114
Echinococcus granulosus tyrosine protein kinase shark 0.00494079 0.00628783 0.00605156
Loa Loa (eye worm) hypothetical protein 0.00528736 0.00852224 0.00852224
Brugia malayi sodium-independent organic anion transporter family protein 0.00619529 0.0143759 0.0141416
Brugia malayi Integrin alpha pat-2 precursor 0.0185687 0.0941505 0.0939351
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0177245 0.088708 0.0884913
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00931827
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0177245 0.088708 0.0884913
Echinococcus multilocularis thioredoxin glutathione reductase 0.0152268 0.0726043 0.0723838
Brugia malayi nuclear receptor NHR-67 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Leishmania major zeta tubulin, putative 0.118525 0.738595 0.736367
Loa Loa (eye worm) integrin beta-2 0.0352098 0.20144 0.20144
Brugia malayi hypothetical protein 0.00544735 0.00955376 0.00931827
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00544735 0.00955376 0.00931827
Brugia malayi alpha-tubulin 0.120024 0.74826 0.7482
Brugia malayi Protein kinase domain containing protein 0.00494079 0.00628783 0.00605156
Leishmania major beta tubulin 0.15907 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.00544735 0.00955376 0.00955376
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Echinococcus multilocularis c src tyrosine kinase 0.00567483 0.0110204 0.0107852
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Loa Loa (eye worm) sodium-independent organic anion transporter 0.00619529 0.0143759 0.0143759
Loa Loa (eye worm) tubulin beta chain 0.0399299 0.231872 0.231872
Brugia malayi Steroid receptor seven-up type 2 0.0177245 0.088708 0.0884913
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00836093 0.0283384 0.0978369
Brugia malayi beta-tubulin, identical 0.15907 1 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00544735 0.00955376 0.00955376
Giardia lamblia Beta tubulin 0.15907 1 1
Schistosoma mansoni tyrosine kinase 0.00567483 0.0110204 0.0110204
Trichomonas vaginalis tubulin alpha chain, putative 0.0884814 0.544896 0.541017
Echinococcus multilocularis epidermal growth factor receptor 0.0349304 0.199639 0.199448
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Echinococcus granulosus beta tubulin 0.15907 1 1
Brugia malayi hypothetical protein 0.00494079 0.00628783 0.00605156
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0138715 0.0638667 0.0636442
Treponema pallidum cell division protein FtsZ 0.0399299 0.231872 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.00836093 0.0283384 0.0283384
Schistosoma mansoni tyrosine kinase 0.00567483 0.0110204 0.0110204
Trypanosoma brucei alpha tubulin 0.120024 0.74826 0.746114
Loa Loa (eye worm) TK/EGFR protein kinase 0.0349304 0.199639 0.199639
Toxoplasma gondii alpha-tubulin I, putative 0.120024 0.74826 0.7482
Trypanosoma brucei beta tubulin 0.15907 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0177245 0.088708 0.088708
Echinococcus multilocularis nuclear receptor nhr 48 0.00836093 0.0283384 0.0281074
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00544735 0.00955376 0.00931827
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Brugia malayi tubulin alpha-2 chain 0.120024 0.74826 0.7482
Trichomonas vaginalis tubulin epsilon chain, putative 0.15907 1 1
Entamoeba histolytica tubulin gamma chain 0.0962752 0.595145 0.592583
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0177245 0.088708 0.0884913
Echinococcus granulosus c src tyrosine kinase 0.00567483 0.0110204 0.0107852
Schistosoma mansoni tyrosine kinase 0.0203931 0.105913 0.105913
Loa Loa (eye worm) hypothetical protein 0.0093636 0.0348029 0.0348029
Echinococcus granulosus tyrosine protein kinase Blk 0.00818023 0.0271733 0.026942
Echinococcus granulosus tyrosine protein kinase Src42A 0.00448943 0.00337781 0.00314085
Schistosoma mansoni retinoic acid receptor RXR 0.0177245 0.088708 0.088708
Echinococcus multilocularis integrin beta 2 0.0261902 0.143288 0.143084
Echinococcus granulosus sodium and chloride dependent glycine 0.00544735 0.00955376 0.00931827
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0177245 0.088708 0.0884913
Brugia malayi hypothetical protein 0.00619529 0.0143759 0.0141416
Echinococcus multilocularis tyrosine kinase 0.00494079 0.00628783 0.00605156
Loa Loa (eye worm) TK protein kinase 0.00818023 0.0271733 0.0271733
Echinococcus multilocularis tubulin alpha chain 0.120024 0.74826 0.7482
Brugia malayi tailless protein 0.00836093 0.0283384 0.0281074
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00891427 0.0319059 0.0316757
Trypanosoma cruzi epsilon tubulin, putative 0.0961493 0.594333 0.590875
Echinococcus multilocularis tubulin, beta 4A class IVa 0.15907 1 1
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Brugia malayi Protein kinase domain containing protein 0.00494079 0.00628783 0.00605156
Echinococcus granulosus nuclear receptor nhr 48 0.00836093 0.0283384 0.0281074
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.00836093 0.0283384 0.0281074
Echinococcus granulosus alpha tubulin 0.120024 0.74826 0.7482
Brugia malayi Carboxylesterase family protein 0.0163717 0.0799859 0.0797671
Loa Loa (eye worm) solute carrier family 6 member 4 0.0320898 0.181325 0.181325
Loa Loa (eye worm) tubulin alpha 2 0.0315426 0.177797 0.177797
Loa Loa (eye worm) tubulin beta-2A chain 0.15907 1 1
Loa Loa (eye worm) serotonin transporter b 0.0320898 0.181325 0.181325
Schistosoma mansoni tubulin subunit beta 0.15907 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Echinococcus multilocularis tubulin epsilon chain 0.0961493 0.594333 0.594237
Echinococcus multilocularis Tubulin beta 2C chain 0.15907 1 1
Giardia lamblia Beta tubulin 0.15907 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0962752 0.595145 0.591694
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0800941 0.490821 0.486481
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.00527653 0.00845244 0.00821668
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi hypothetical protein 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) tubulin alpha 2 0.0800941 0.490821 0.490821
Brugia malayi nuclear hormone receptor family member odr-7 0.00836093 0.0283384 0.0281074
Entamoeba histolytica tubulin family protein 0.15907 1 1
Toxoplasma gondii tubulin, putative 0.00766791 0.0238703 0.0236382
Trypanosoma brucei epsilon tubulin 0.0884814 0.544896 0.541017
Echinococcus granulosus Tubulin beta 2C chain 0.15907 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0714725 0.435236 0.430421
Echinococcus granulosus acetylcholinesterase 0.0163717 0.0799859 0.0797671
Loa Loa (eye worm) alpha-tubulin 0.120024 0.74826 0.74826
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.00402078 0.000356293 0.000118611
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00931827
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.00567483 0.0110204 0.0107852
Onchocerca volvulus 0.00494079 0.00628783 0.0210644
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00955376
Loa Loa (eye worm) hypothetical protein 0.0124527 0.0547191 0.0547191
Echinococcus granulosus Nuclear hormone receptor HR96 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) tubulin gamma chain 0.0962752 0.595145 0.595145
Echinococcus granulosus tubulin delta chain 0.0399299 0.231872 0.231689
Echinococcus granulosus Tubulin beta 2C chain 0.15907 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.00635363 0.0153968 0.0153968
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.00494079 0.00628783 0.00605156
Schistosoma mansoni tyrosine kinase 0.0349304 0.199639 0.199639
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00448943 0.00337781 0.00314085
Schistosoma mansoni organic anion transporter 0.00619529 0.0143759 0.0143759
Brugia malayi Furin-like cysteine rich region family protein 0.0349304 0.199639 0.199448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0177245 0.088708 0.088708
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0177245 0.088708 0.0884913
Echinococcus granulosus insulin receptor 0.0135521 0.0618072 0.0615841
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.00836093 0.0283384 0.0978369
Leishmania major epsilon tubulin, putative 0.0961493 0.594333 0.590875
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.00544735 0.00955376 1
Trypanosoma cruzi zeta tubulin, putative 0.118525 0.738595 0.736367
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.00619529 0.0143759 0.0141416
Echinococcus multilocularis tyrosine protein kinase shark 0.00494079 0.00628783 0.00605156
Entamoeba histolytica tubulin alpha-1 chain 0.120024 0.74826 0.746667
Loa Loa (eye worm) BEN-1 protein 0.15907 1 1
Schistosoma mansoni tubulin subunit alpha 0.120024 0.74826 0.74826
Echinococcus granulosus tyrosine protein kinase Fyn 0.00891427 0.0319059 0.0316757
Trypanosoma brucei beta tubulin 0.0884814 0.544896 0.541017
Loa Loa (eye worm) hypothetical protein 0.124096 0.77451 0.77451
Echinococcus granulosus tyrosine protein kinase Fyn 0.00891427 0.0319059 0.0316757
Schistosoma mansoni tubulin subunit beta 0.0399299 0.231872 0.231872
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.00836093 0.0283384 0.0281074
Trichomonas vaginalis tubulin gamma chain, putative 0.0962752 0.595145 0.591694
Onchocerca volvulus 0.00494079 0.00628783 0.0210644
Echinococcus multilocularis FTZ F1 alpha 0.0177245 0.088708 0.0884913
Loa Loa (eye worm) acetylcholinesterase 1 0.0163717 0.0799859 0.0799859
Echinococcus granulosus tyrosine protein kinase ABL1 0.0278565 0.154032 0.153831
Loa Loa (eye worm) hypothetical protein 0.0109524 0.0450462 0.0450462
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0871287 0.536175 0.536065
Echinococcus granulosus tubulin alpha chain 0.120024 0.74826 0.7482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0177245 0.088708 0.0884913
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0177245 0.088708 0.0884913
Trichomonas vaginalis conserved hypothetical protein 0.0399299 0.231872 0.225324
Plasmodium falciparum alpha tubulin 1 0.120024 0.74826 0.746114
Loa Loa (eye worm) hypothetical protein 0.0800941 0.490821 0.490821
Trichomonas vaginalis tubulin gamma chain, putative 0.0399299 0.231872 0.225324
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.00836093 0.0283384 0.0283384
Onchocerca volvulus 0.00494079 0.00628783 0.0210644
Schistosoma mansoni tubulin subunit beta 0.15907 1 1
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Brugia malayi Cell division protein ftsZ 0.0399299 0.231872 0.231689
Schistosoma mansoni tyrosine kinase 0.0146432 0.0688417 0.0688417
Onchocerca volvulus 0.00544735 0.00955376 0.0324353
Echinococcus multilocularis carboxylesterase 5A 0.0163717 0.0799859 0.0797671
Schistosoma mansoni tyrosine kinase 0.0203931 0.105913 0.105913
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0320898 0.181325 0.181325
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00818023 0.0271733 0.026942
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Trichomonas vaginalis tubulin beta chain, putative 0.120024 0.74826 0.746114
Brugia malayi nuclear receptor RXR 0.00836093 0.0283384 0.0281074
Giardia lamblia Gamma tubulin 0.0962752 0.595145 0.591694
Schistosoma mansoni tyrosine kinase 0.0167024 0.0821178 0.0821178
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Schistosoma mansoni integrin alpha 0.0185687 0.0941505 0.0941505
Echinococcus granulosus Tubulin alpha 1 chain 0.120024 0.74826 0.7482
Trypanosoma brucei zeta tubulin 0.118525 0.738595 0.736367
Loa Loa (eye worm) tubulin alpha-3 chain 0.0714725 0.435236 0.435236
Echinococcus granulosus tubulin epsilon chain 0.0961493 0.594333 0.594237
Loa Loa (eye worm) agrin synaptic family protein 0.00400239 0.00023771 0.00023771
Trichomonas vaginalis tubulin beta chain, putative 0.0485515 0.287457 0.281383
Echinococcus multilocularis beta tubulin 0.15907 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00544735 0.00955376 0.00931827
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0177245 0.088708 0.0884913
Echinococcus granulosus tubulin alpha chain 0.120024 0.74826 0.7482
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Loa Loa (eye worm) hypothetical protein 0.0163717 0.0799859 0.0799859
Loa Loa (eye worm) hypothetical protein 0.00494079 0.00628783 0.00628783
Loa Loa (eye worm) hypothetical protein 0.0049633 0.00643297 0.00643297
Loa Loa (eye worm) hypothetical protein 0.0320898 0.181325 0.181325
Plasmodium vivax tubulin beta chain, putative 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Leishmania major beta tubulin 0.15907 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) TK/INSR protein kinase 0.0135521 0.0618072 0.0618072
Echinococcus granulosus tyrosine protein kinase Btk29A 0.00567483 0.0110204 0.0107852
Trichomonas vaginalis tubulin, putative 0.15907 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0177245 0.088708 0.088708
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0177245 0.088708 0.088708
Onchocerca volvulus 0.00494079 0.00628783 0.0210644
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0146432 0.0688417 0.0686203
Schistosoma mansoni thyroid hormone receptor 0.0177245 0.088708 0.088708
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0177245 0.088708 0.0884913
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0177245 0.088708 0.308023
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.00836093 0.0283384 0.0281074
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.00567483 0.0110204 0.0110204
Schistosoma mansoni steroid hormone receptor ad4bp 0.0177245 0.088708 0.088708
Loa Loa (eye worm) tubulin beta chain 0.15907 1 1
Brugia malayi Tubulin beta chain 0.0399299 0.231872 0.231689
Echinococcus granulosus integrin beta 2 0.0261902 0.143288 0.143084
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Loa Loa (eye worm) TK protein kinase 0.00693023 0.0191143 0.0191143
Echinococcus granulosus thioredoxin glutathione reductase 0.0152268 0.0726043 0.0723838
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.00891427 0.0319059 0.0316757
Onchocerca volvulus 0.00544735 0.00955376 0.0324353
Loa Loa (eye worm) TK/ABL protein kinase 0.0278565 0.154032 0.154032
Echinococcus granulosus tubulin alpha 1C chain 0.120024 0.74826 0.7482
Echinococcus multilocularis tubulin alpha chain 0.120024 0.74826 0.7482
Trypanosoma brucei alpha tubulin, putative 0.0485515 0.287457 0.281383
Schistosoma mansoni tubulin subunit beta 0.15907 1 1
Brugia malayi hypothetical protein 0.00836093 0.0283384 0.0281074
Trypanosoma cruzi alpha tubulin, putative 0.120024 0.74826 0.746114
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0884814 0.544896 0.544788
Schistosoma mansoni nuclear hormone receptor 0.00836093 0.0283384 0.0283384
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0177245 0.088708 0.0884913
Schistosoma mansoni tubulin subunit gamma 0.0962752 0.595145 0.595145
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00544735 0.00955376 0.00931827
Brugia malayi glutathione transferase 0.0151367 0.0720236 0.071803
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00836093 0.0283384 0.0281074
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Onchocerca volvulus 0.00494079 0.00628783 0.0210644
Schistosoma mansoni coup transcription factor 0.0177245 0.088708 0.088708
Brugia malayi Kelch motif family protein 0.00528736 0.00852224 0.0082865
Echinococcus multilocularis ecdysone induced protein 78C 0.0177245 0.088708 0.0884913
Trypanosoma brucei epsilon tubulin 0.0961493 0.594333 0.590875
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00544735 0.00955376 0.00955376
Echinococcus granulosus tubulin subunit beta 0.15907 1 1
Trypanosoma brucei alpha tubulin 0.120024 0.74826 0.746114
Trypanosoma cruzi tubulin delta chain 0.0871287 0.536175 0.532221
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0177245 0.088708 0.0884913
Brugia malayi Tubulin alpha chain 0.120024 0.74826 0.7482
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.00527653 0.00845244 0.00845244
Echinococcus multilocularis tubulin alpha chain 0.120024 0.74826 0.7482
Echinococcus granulosus sodium and chloride dependent glycine 0.00544735 0.00955376 0.00931827
Onchocerca volvulus Tyrosine kinase homolog 0.00402078 0.000356293 0.000412863
Trypanosoma cruzi zeta tubulin, putative 0.118525 0.738595 0.736367
Onchocerca volvulus 0.00619529 0.0143759 0.0492243
Giardia lamblia Delta tubulin 0.0399299 0.231872 0.225324
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.00402078 0.000356293 0.000118611
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Leishmania major beta tubulin 0.15907 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0349304 0.199639 0.199448
Trypanosoma brucei beta tubulin 0.15907 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0399299 0.231872 0.225324
Echinococcus multilocularis integrin alpha ps 0.00761631 0.0235376 0.0233055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0177245 0.088708 0.088708
Toxoplasma gondii beta tubulin 0.15907 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Echinococcus granulosus glutathione S transferase Mu 1 0.0271793 0.149666 0.149463
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0093636 0.0348029 0.0348029
Loa Loa (eye worm) nuclear hormone receptor 0.00836093 0.0283384 0.0283384
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Trichomonas vaginalis tubulin alpha chain, putative 0.0485515 0.287457 0.281383
Trichomonas vaginalis tubulin gamma chain, putative 0.15907 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0177245 0.088708 0.0884913
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0093636 0.0348029 0.0348029
Echinococcus multilocularis tubulin alpha 0.0884814 0.544896 0.544788
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.00527653 0.00845244 0.00821668
Schistosoma mansoni sodium-dependent amino acid transporter 0.00544735 0.00955376 0.00955376
Loa Loa (eye worm) hypothetical protein 0.124096 0.77451 0.77451
Echinococcus granulosus tubulin alpha chain 0.120024 0.74826 0.7482
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0163717 0.0799859 0.0799859
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Echinococcus granulosus ecdysone induced protein 78C 0.0177245 0.088708 0.0884913
Onchocerca volvulus 0.00494079 0.00628783 0.0210644
Trypanosoma brucei trypanothione reductase 0.0152268 0.0726043 0.0646987
Leishmania major delta tubulin, putative 0.0871287 0.536175 0.532221
Schistosoma mansoni tubulin subunit beta 0.15907 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.120024 0.74826 0.7482
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Schistosoma mansoni tyrosine kinase 0.00891427 0.0319059 0.0319059
Loa Loa (eye worm) beta-tubulin 0.15907 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0177245 0.088708 0.0884913
Echinococcus granulosus tubulin alpha chain 0.120024 0.74826 0.7482
Echinococcus granulosus Tubulin alpha 1 chain 0.120024 0.74826 0.7482
Loa Loa (eye worm) tubulin beta-4 chain 0.15907 1 1
Echinococcus multilocularis 0.00972448 0.0371296 0.0369006
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Loa Loa (eye worm) hypothetical protein 0.00400239 0.00023771 0.00023771
Schistosoma mansoni memapsin-2 (A01 family) 0.052046 0.309987 0.309987
Trichomonas vaginalis tubulin alpha chain, putative 0.0485515 0.287457 0.281383
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00891427 0.0319059 0.0316757
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0177245 0.088708 0.088708
Echinococcus multilocularis integrin alpha ps 0.00761631 0.0235376 0.0233055
Echinococcus granulosus tyrosine protein kinase Srms 0.00494079 0.00628783 0.00605156
Echinococcus multilocularis Solute carrier organic anion transporter family 0.00619529 0.0143759 0.0141416
Giardia lamblia Beta tubulin 0.15907 1 1
Onchocerca volvulus 0.00619529 0.0143759 0.0492243
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0800941 0.490821 0.490821
Brugia malayi Tubulin beta-1 chain 0.15907 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0399299 0.231872 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.00544735 0.00955376 0.00931827
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0177245 0.088708 0.0884913
Plasmodium falciparum tubulin epsilon chain, putative 0.0961493 0.594333 0.590875
Giardia lamblia Epsilon tubulin 0.0475978 0.281309 0.275183
Echinococcus granulosus Nuclear hormone receptor HR96 0.00836093 0.0283384 0.0281074
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0152268 0.0726043 0.287136
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00544735 0.00955376 0.00955376
Schistosoma mansoni integrin beta subunit 0.0209028 0.109199 0.109199
Trichomonas vaginalis tubulin, putative 0.0485515 0.287457 0.281383
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0177245 0.088708 0.0884913
Toxoplasma gondii hypothetical protein 0.00544735 0.00955376 0.00931827
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00836093 0.0283384 0.0281074
Echinococcus granulosus Tubulin beta 2C chain 0.15907 1 1
Echinococcus granulosus integrin alpha ps 0.00761631 0.0235376 0.0233055
Onchocerca volvulus 0.0320898 0.181325 0.630483
Giardia lamblia Alpha-tubulin 0.120024 0.74826 0.746114
Echinococcus multilocularis acetylcholinesterase 0.0163717 0.0799859 0.0797671
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0128508 0.0572857 0.0570616
Loa Loa (eye worm) integrin alpha pat-2 0.0277687 0.153465 0.153465
Leishmania major beta tubulin 0.15907 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.120024 0.74826 0.7482
Schistosoma mansoni sodium/chloride dependent transporter 0.00544735 0.00955376 0.00955376
Schistosoma mansoni alpha tubulin 0.120024 0.74826 0.74826
Echinococcus granulosus tyrosine protein kinase Fps85D 0.00494079 0.00628783 0.00605156
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Plasmodium vivax delta tubulin, putative 0.0399299 0.231872 0.225324
Echinococcus multilocularis tubulin delta chain 0.0399299 0.231872 0.231689
Leishmania major gamma-tubulin 0.0962752 0.595145 0.591694
Echinococcus multilocularis tyrosine protein kinase Srms 0.00818023 0.0271733 0.026942
Trichomonas vaginalis tubulin beta chain, putative 0.120024 0.74826 0.746114
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi Tubulin alpha-2 chain 0.120024 0.74826 0.7482
Schistosoma mansoni serine/threonine protein kinase 0.00442484 0.00296135 0.00296135
Plasmodium falciparum thioredoxin reductase 0.0152268 0.0726043 0.0646987
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Loa Loa (eye worm) SRC-1 0.00891427 0.0319059 0.0319059
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi Tubulin alpha-2 chain 0.120024 0.74826 0.7482
Brugia malayi nuclear receptor NHR-88 0.0177245 0.088708 0.0884913
Echinococcus granulosus tyrosine protein kinase HCK 0.00693023 0.0191143 0.0188811
Schistosoma mansoni follistatin 0.00400239 0.00023771 0.00023771
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Trypanosoma brucei epsilon tubulin 0.0961493 0.594333 0.590875
Echinococcus multilocularis sodium and chloride dependent glycine 0.00544735 0.00955376 0.00931827
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0320898 0.181325 0.18113
Brugia malayi Tubulin beta chain 0.0485515 0.287457 0.287288
Schistosoma mansoni tyrosine kinase 0.0266066 0.145973 0.145973
Brugia malayi sodium-independent organic anion transporter family protein 0.00619529 0.0143759 0.0141416
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0485515 0.287457 0.281383
Trypanosoma cruzi epsilon tubulin, putative 0.0961493 0.594333 0.590875
Brugia malayi Tyrosine-protein kinase abl-1 0.0144367 0.0675107 0.067289
Schistosoma mansoni tubulin subunit alpha 0.0399299 0.231872 0.231872
Loa Loa (eye worm) BEN-1 protein 0.15907 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0177245 0.088708 0.0884913
Schistosoma mansoni nuclear receptor 0.00836093 0.0283384 0.0283384
Echinococcus multilocularis acetylcholinesterase 0.0163717 0.0799859 0.0797671
Echinococcus multilocularis Tubulin beta 2C chain 0.15907 1 1
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi ecdysone receptor 0.00836093 0.0283384 0.0281074
Trypanosoma brucei alpha tubulin 0.120024 0.74826 0.746114
Schistosoma mansoni organic anion transporter 0.00619529 0.0143759 0.0143759
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Plasmodium vivax thioredoxin reductase, putative 0.0152268 0.0726043 0.0646987
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) hypothetical protein 0.00400239 0.00023771 0.00023771
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00544735 0.00955376 0.00931827
Schistosoma mansoni alpha tubulin 0.120024 0.74826 0.74826
Echinococcus granulosus tubulin gamma 1 chain 0.0962752 0.595145 0.595049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00818023 0.0271733 0.026942
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00931827
Toxoplasma gondii thioredoxin reductase 0.0152268 0.0726043 0.0723838
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00931827
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0177245 0.088708 0.0884913
Brugia malayi prostaglandin transporter 0.00619529 0.0143759 0.0141416
Schistosoma mansoni tubulin subunit epsilon 0.0961493 0.594333 0.594333
Echinococcus granulosus acetylcholinesterase 0.0163717 0.0799859 0.0797671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0177245 0.088708 0.088708
Loa Loa (eye worm) DR-78 0.00836093 0.0283384 0.0283384
Plasmodium vivax tubulin alpha chain, putative 0.120024 0.74826 0.746114
Echinococcus multilocularis tubulin alpha chain 0.120024 0.74826 0.7482
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Loa Loa (eye worm) thioredoxin reductase 0.0152268 0.0726043 0.0726043
Echinococcus multilocularis tyrosine protein kinase HCK 0.00693023 0.0191143 0.0188811
Brugia malayi SH2 domain containing protein 0.00494079 0.00628783 0.00605156
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00931827
Loa Loa (eye worm) carboxylesterase 0.0163717 0.0799859 0.0799859
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Brugia malayi tubulin alpha chain - mouse 0.120024 0.74826 0.7482
Brugia malayi nuclear hormone receptor 0.0177245 0.088708 0.0884913
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00544735 0.00955376 0.00955376
Echinococcus granulosus Tubulin alpha 1 chain 0.120024 0.74826 0.7482
Echinococcus multilocularis tubulin alpha 1C chain 0.120024 0.74826 0.7482
Echinococcus granulosus beta tubulin 0.15907 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0093636 0.0348029 0.0345734
Schistosoma mansoni thyroid hormone receptor 0.0177245 0.088708 0.088708
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Brugia malayi hypothetical protein 0.00619529 0.0143759 0.0141416
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Loa Loa (eye worm) tubulin alpha-2 chain 0.120024 0.74826 0.74826
Echinococcus multilocularis tubulin alpha chain 0.120024 0.74826 0.7482
Loa Loa (eye worm) tubulin alpha chain 0.120024 0.74826 0.74826
Brugia malayi sodium-independent organic anion transporter family protein 0.00619529 0.0143759 0.0141416
Loa Loa (eye worm) hypothetical protein 0.0093636 0.0348029 0.0348029
Onchocerca volvulus 0.0177245 0.088708 0.308023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.00836093 0.0283384 0.0281074
Loa Loa (eye worm) hypothetical protein 0.0320898 0.181325 0.181325
Entamoeba histolytica tubulin family protein 0.15907 1 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.00619529 0.0143759 0.0141416
Brugia malayi steroid hormone receptor 0.0177245 0.088708 0.0884913
Echinococcus multilocularis tubulin gamma 1 chain 0.0962752 0.595145 0.595049
Loa Loa (eye worm) alpha-tubulin 0.120024 0.74826 0.74826
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0177245 0.088708 0.088708
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0093636 0.0348029 0.0345734
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0475978 0.281309 0.281138
Loa Loa (eye worm) tubulin alpha chain 0.120024 0.74826 0.74826
Echinococcus multilocularis integrin alpha 3 0.0146032 0.0685838 0.0683623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0149732 0.0709692 0.0707483
Brugia malayi Carboxylesterase family protein 0.0163717 0.0799859 0.0797671
Loa Loa (eye worm) hypothetical protein 0.0149179 0.0706129 0.0706129
Schistosoma mansoni tyrosine kinase 0.00494079 0.00628783 0.00628783
Leishmania major beta tubulin 0.15907 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.120024 0.74826 0.746114
Echinococcus granulosus serotonin transporter 0.0320898 0.181325 0.18113
Echinococcus granulosus tyrosine protein kinase Src64B 0.00891427 0.0319059 0.0316757
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00544735 0.00955376 0.00931827
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.00891427 0.0319059 0.0316757
Echinococcus granulosus tubulin alpha 0.0884814 0.544896 0.544788
Mycobacterium ulcerans cell division protein FtsZ 0.0399299 0.231872 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00544735 0.00955376 0.00955376
Trypanosoma cruzi trypanothione reductase, putative 0.0152268 0.0726043 0.0646987
Toxoplasma gondii beta-tubulin, putative 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Echinococcus multilocularis epidermal growth factor receptor 0.0203931 0.105913 0.105701
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177245 0.088708 0.0884913
Trichomonas vaginalis tubulin, putative 0.0485515 0.287457 0.281383
Onchocerca volvulus 0.00619529 0.0143759 0.0492243
Plasmodium falciparum tubulin beta chain 0.15907 1 1
Brugia malayi conserved hypotetical protein 0.00836093 0.0283384 0.0281074
Schistosoma mansoni tyrosine kinase 0.00494079 0.00628783 0.00628783
Loa Loa (eye worm) hypothetical protein 0.120024 0.74826 0.74826
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0177245 0.088708 0.088708
Echinococcus granulosus fibroblast growth factor receptor 4 0.0146432 0.0688417 0.0686203
Brugia malayi Protein kinase domain containing protein 0.00494079 0.00628783 0.00605156
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0093636 0.0348029 0.0348029
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.00891427 0.0319059 0.0316757
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0203931 0.105913 0.105701
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0399299 0.231872 0.225324
Plasmodium falciparum transporter, putative 0.00544735 0.00955376 0.00111071
Echinococcus multilocularis tyrosine protein kinase Blk 0.00818023 0.0271733 0.026942
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Toxoplasma gondii transporter, major facilitator family protein 0.00619529 0.0143759 0.0141416
Onchocerca volvulus 0.00836093 0.0283384 0.0978369
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Schistosoma mansoni tyrosine kinase 0.0167024 0.0821178 0.0821178
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.00891427 0.0319059 0.0316757
Brugia malayi Tubulin gamma chain 0.0962752 0.595145 0.595049
Trichomonas vaginalis tubulin beta chain, putative 0.120024 0.74826 0.746114
Brugia malayi protein-tyrosine kinase 0.00818023 0.0271733 0.026942
Schistosoma mansoni tubulin subunit beta 0.15907 1 1
Onchocerca volvulus Putative organic anion transporter 0.00619529 0.0143759 0.0492243
Toxoplasma gondii alpha tubulin TUBA1 0.120024 0.74826 0.7482
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Plasmodium vivax amine transporter, putative 0.00544735 0.00955376 0.00111071
Echinococcus multilocularis tubulin subunit TubB 0.120024 0.74826 0.7482
Trichomonas vaginalis tubulin epsilon chain, putative 0.120024 0.74826 0.746114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0177245 0.088708 0.0884913
Plasmodium falciparum tubulin delta chain, putative 0.0399299 0.231872 0.225324
Onchocerca volvulus Bile acid receptor homolog 0.0177245 0.088708 0.308023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0177245 0.088708 0.0884913
Echinococcus granulosus epidermal growth factor receptor 0.0203931 0.105913 0.105701
Echinococcus multilocularis tubulin alpha 1C chain 0.120024 0.74826 0.7482
Trypanosoma cruzi tubulin delta chain 0.0871287 0.536175 0.532221
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.00836093 0.0283384 0.0281074
Echinococcus multilocularis tyrosine protein kinase Src64B 0.00891427 0.0319059 0.0316757
Onchocerca volvulus 0.00619529 0.0143759 0.0492243
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049633 0.00643297 0.00619673
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0399299 0.231872 1
Schistosoma mansoni integrin alpha-ps 0.00761631 0.0235376 0.0235376
Schistosoma mansoni zinc finger protein 0.00836093 0.0283384 0.0283384
Plasmodium falciparum amino acid transporter, putative 0.00544735 0.00955376 0.00111071
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi Integrin beta pat-3 precursor 0.0352098 0.20144 0.20125
Echinococcus granulosus tyrosine protein kinase Src42A 0.00891427 0.0319059 0.0316757
Echinococcus multilocularis tyrosine protein kinase Fgr 0.00891427 0.0319059 0.0316757
Plasmodium vivax glutathione reductase, putative 0.0152268 0.0726043 0.0646987
Loa Loa (eye worm) hypothetical protein 0.00619529 0.0143759 0.0143759
Brugia malayi hypothetical protein 0.0093636 0.0348029 0.0345734
Trypanosoma cruzi tubulin gamma chain 0.0962752 0.595145 0.591694
Loa Loa (eye worm) glutathione reductase 0.0152268 0.0726043 0.0726043
Leishmania major beta tubulin 0.15907 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.00836093 0.0283384 0.0281074
Plasmodium vivax tubulin epsilon chain, putative 0.0961493 0.594333 0.590875
Onchocerca volvulus 0.00836093 0.0283384 0.0978369
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0138715 0.0638667 0.0636442
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0177245 0.088708 0.088708
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0093636 0.0348029 0.0345734
Schistosoma mansoni tyrosine kinase 0.00435778 0.002529 0.002529
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049633 0.00643297 0.00619673
Schistosoma mansoni nuclear hormone receptor 0.0177245 0.088708 0.088708
Echinococcus granulosus tyrosine kinase 0.00494079 0.00628783 0.00605156
Onchocerca volvulus Putative organic anion transporter 0.00619529 0.0143759 0.0492243
Echinococcus granulosus carboxylesterase 5A 0.0163717 0.0799859 0.0797671
Brugia malayi Nuclear hormone receptor E75 0.00836093 0.0283384 0.0281074
Brugia malayi photoreceptor-specific nuclear receptor 0.0177245 0.088708 0.0884913
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0177245 0.088708 0.0884913
Loa Loa (eye worm) hypothetical protein 0.00836093 0.0283384 0.0283384
Plasmodium vivax hypothetical protein, conserved 0.00544735 0.00955376 0.00111071
Toxoplasma gondii NADPH-glutathione reductase 0.00527653 0.00845244 0.00821668
Loa Loa (eye worm) hypothetical protein 0.0093636 0.0348029 0.0348029
Leishmania major trypanothione reductase 0.0152268 0.0726043 0.0646987
Plasmodium falciparum glutathione reductase 0.0152268 0.0726043 0.0646987
Loa Loa (eye worm) tubulin beta-1 chain 0.15907 1 1
Brugia malayi hypothetical protein 0.0093636 0.0348029 0.0345734
Loa Loa (eye worm) TK/FER protein kinase 0.00494079 0.00628783 0.00628783
Loa Loa (eye worm) hypothetical protein 0.00544735 0.00955376 0.00955376
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0177245 0.088708 0.0884913
Schistosoma mansoni alpha tubulin 0.120024 0.74826 0.74826
Trichomonas vaginalis tubulin beta chain, putative 0.15907 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.15907 1 1
Entamoeba histolytica protein kinase, putative 0.00693023 0.0191143 0.0129076
Echinococcus granulosus tyrosine kinase 0.00818023 0.0271733 0.026942
Onchocerca volvulus 0.0485515 0.287457 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0177245 0.088708 0.088708
Trichomonas vaginalis tubulin beta chain, putative 0.120024 0.74826 0.746114
Brugia malayi glutathione reductase 0.0152268 0.0726043 0.0723838
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0177245 0.088708 0.088708
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.120024 0.74826 0.746114
Echinococcus granulosus organic anion transporting polypeptide 30B 0.00619529 0.0143759 0.0141416
Leishmania major beta tubulin 0.15907 1 1
Trypanosoma brucei zeta tubulin, putative 0.118525 0.738595 0.736367
Schistosoma mansoni sodium/chloride dependent transporter 0.0320898 0.181325 0.181325
Trichomonas vaginalis tubulin alpha chain, putative 0.0485515 0.287457 0.281383
Echinococcus multilocularis tyrosine protein kinase Abl 0.0144367 0.0675107 0.067289
Echinococcus multilocularis insulin receptor 0.0135521 0.0618072 0.0615841
Plasmodium falciparum alpha tubulin 2 0.120024 0.74826 0.746114
Schistosoma mansoni agrin 0.00400239 0.00023771 0.00023771
Echinococcus granulosus Tubulin beta 2C chain 0.15907 1 1
Trypanosoma cruzi MFS transporter, putative 0.00619529 0.0143759 0.00597396
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00544735 0.00955376 0.00931827
Loa Loa (eye worm) nuclear receptor NHR-67 0.00836093 0.0283384 0.0283384
Trichomonas vaginalis tubulin epsilon chain, putative 0.15907 1 1
Schistosoma mansoni tubulin subunit alpha 0.120024 0.74826 0.74826
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0177245 0.088708 0.0884913
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Toxoplasma gondii beta-1 tubulin, putative 0.15907 1 1
Schistosoma mansoni tyrosine kinase 0.00891427 0.0319059 0.0319059
Brugia malayi Tyrosine-protein kinase abl-1 0.0141539 0.0656868 0.0654647
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0177245 0.088708 0.0884913
Brugia malayi Protein kinase domain containing protein 0.00494079 0.00628783 0.00605156
Plasmodium vivax tubulin alpha chain, putative 0.120024 0.74826 0.746114
Leishmania major alpha tubulin 0.120024 0.74826 0.746114
Echinococcus granulosus tubulin alpha chain 0.120024 0.74826 0.7482
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0146432 0.0688417 0.0686203
Brugia malayi SRC-1 0.00891427 0.0319059 0.0316757
Trypanosoma brucei tubulin gamma chain 0.0962752 0.595145 0.591694
Leishmania major beta tubulin 0.15907 1 1
Leishmania major beta tubulin 0.15907 1 1
Schistosoma mansoni nuclear receptor 0.00836093 0.0283384 0.0283384
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0177245 0.088708 0.0884913
Loa Loa (eye worm) hypothetical protein 0.0093636 0.0348029 0.0348029
Plasmodium falciparum tubulin gamma chain 0.0962752 0.595145 0.591694
Schistosoma mansoni RAR-like nuclear receptor 0.0177245 0.088708 0.088708
Trypanosoma cruzi beta tubulin, putative 0.15907 1 1
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.00400239 0.00023771 0.00023771
Trypanosoma brucei beta tubulin 0.15907 1 1
Loa Loa (eye worm) hypothetical protein 0.0177245 0.088708 0.088708
Brugia malayi Nuclear hormone receptor-like 1 0.0093636 0.0348029 0.0345734

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.45 uM Trypanocidal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs ChEMBL. 21315611
IC90 (functional) = 4.34 uM Trypanocidal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs ChEMBL. 21315611

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 21315611
Trypanosoma brucei ChEMBL23 21315611

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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