Detailed information for compound 1512794

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.585 | Formula: C27H34N4O
  • H donors: 1 H acceptors: 2 LogP: 4.9 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN([C@@H]1CCn2c(C1)ccn2)CCCCNC(=O)c1ccc(cc1)c1ccccc1
  • InChi: 1S/C27H34N4O/c1-2-18-30(25-15-20-31-26(21-25)14-17-29-31)19-7-6-16-28-27(32)24-12-10-23(11-13-24)22-8-4-3-5-9-22/h3-5,8-14,17,25H,2,6-7,15-16,18-21H2,1H3,(H,28,32)/t25-/m1/s1
  • InChiKey: UTFOVXIJDJSMKK-RUZDIDTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0167 0.0691
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0025 0.0077 0.0445
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0047 0.0047
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0047 0.0288
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0055 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0081 0.0333 0.3486
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0259 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.0016 0.0036 0.0151
Echinococcus granulosus intermediate filament protein 0.0026 0.0083 0.0083
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Brugia malayi Carboxylesterase family protein 0.007 0.0285 0.1179
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0047 0.0192
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0047 0.0047
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0137 0.0671
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0424
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0047 0.0047
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0005 0.0005
Onchocerca volvulus 0.0018 0.0043 0.0268
Brugia malayi AKH receptor 0.0019 0.0047 0.0192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0353
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0083 0.0343
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0213 0.0942 0.0942
Toxoplasma gondii aspartyl protease 0.0045 0.0167 0.1708
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0134 0.0134
Echinococcus granulosus o acyltransferase membrane bound domain 0.0213 0.0942 0.0942
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0168 0.0168
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0012 0.0012
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0136 0.0136
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0153 0.1088
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0043 0.0043
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0055 0.0055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0055 0.0513
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1131 0.8826
Echinococcus granulosus sex peptide receptor 0.0019 0.0047 0.0047
Trypanosoma cruzi glycerol uptake protein, putative 0.0213 0.0942 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Loa Loa (eye worm) hypothetical protein 0.0049 0.0185 0.0185
Onchocerca volvulus 0.0012 0.0016 0.0099
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0162 0.0705 0.0705
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0036 0.0292
Brugia malayi G-protein coupled receptor 0.0019 0.0047 0.0192
Plasmodium vivax plasmepsin V, putative 0.0045 0.0167 0.1708
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0047 0.0047
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0213 0.0942 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1131 0.8826
Echinococcus multilocularis geminin 0.0166 0.0725 0.0725
Schistosoma mansoni DNA helicase recq5 0.002 0.0055 0.0055
Leishmania major glycerol uptake protein, putative 0.0213 0.0942 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0043 0.018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0043 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0043 0.0043
Mycobacterium ulcerans hydrolase/amidase 0.028 0.1248 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0081 0.0333 0.0333
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0153 0.1088
Plasmodium falciparum plasmepsin I 0.0081 0.0333 0.3242
Echinococcus granulosus neuropeptide receptor 0.0019 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0166 0.0725 0.0725
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0066
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0047 0.0047
Brugia malayi nuclear hormone receptor 0.0018 0.0043 0.018
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0055 0.0055
Schistosoma mansoni lamin 0.0026 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0047 0.0047
Trichomonas vaginalis transmembrane protein nessy, putative 0.0213 0.0942 0.7329
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0259 0.2457
Brugia malayi hypothetical protein 0.0009 0.0005 0.0019
Brugia malayi MBOAT family protein 0.0213 0.0942 0.3895
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0055
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0055 0.0055
Schistosoma mansoni cpg binding protein 0.0028 0.0091 0.0091
Brugia malayi peptidase family M13 containing protein 0.0024 0.0071 0.0294
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0047 0.0047
Brugia malayi nuclear receptor NHR-88 0.0018 0.0043 0.018
Loa Loa (eye worm) RecQ helicase 0.002 0.0055 0.0055
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0012 0.0016 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0113 0.0113
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Brugia malayi intermediate filament protein 0.0026 0.0083 0.0343
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.0251
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Echinococcus multilocularis lamin 0.0026 0.0083 0.0083
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0047 0.0047
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0055 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0167 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0073 0.0295 0.0295
Schistosoma mansoni lamin 0.0026 0.0083 0.0083
Echinococcus granulosus carboxylesterase 5A 0.007 0.0285 0.0285
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Plasmodium vivax aspartyl proteinase, putative 0.0081 0.0333 0.3486
Toxoplasma gondii aspartyl protease ASP1 0.0081 0.0333 0.3486
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1131 0.8826
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0047 0.0047
Echinococcus granulosus g protein coupled receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0043 0.0043
Echinococcus granulosus hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0115 0.0475
Loa Loa (eye worm) MBOAT family protein 0.0213 0.0942 0.0942
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0724
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0047 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0282
Brugia malayi ephrin receptor 1 precursor 0.003 0.0101 0.0417
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0041
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0081 0.0333 0.0333
Loa Loa (eye worm) peptidase family M13 containing protein 0.0073 0.0295 0.0295
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0168 0.0697
Echinococcus multilocularis musashi 0.0026 0.0083 0.0083
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0047 0.0047
Echinococcus granulosus ephrin type A receptor 4 A 0.0064 0.0254 0.0254
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0004
Onchocerca volvulus Matrix metalloproteinase homolog 0.0099 0.0415 0.2565
Brugia malayi hypothetical protein 0.0009 0.0005 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0005 0.0005
Onchocerca volvulus 0.0019 0.0047 0.0288
Trypanosoma cruzi GUP1, putative 0.0213 0.0942 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0064 0.0254 0.0254
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0047 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Plasmodium falciparum plasmepsin V 0.0045 0.0167 0.1397
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0098 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0044 0.0166 0.0166
Onchocerca volvulus 0.0012 0.0016 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Schistosoma mansoni amine GPCR 0.0019 0.0047 0.0047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0016 0.0016
Echinococcus granulosus orexin receptor type 2 0.0019 0.0047 0.0047
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0137 0.1023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0043 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0424
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.005 0.0189 0.0189
Brugia malayi hypothetical protein 0.0025 0.0077 0.0317
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0012 0.0012
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.213 0.213
Brugia malayi steroid hormone receptor 0.0018 0.0043 0.018
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0605 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0026 0.0079 0.0079
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0047 0.0047
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0055 0.0209
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0013 0.0013
Schistosoma mansoni neuropeptide receptor 0.0019 0.0047 0.0047
Echinococcus granulosus endothelin converting enzyme 1 0.0098 0.0412 0.0412
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0167 0.1708
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0054 0.021 0.3299
Schistosoma mansoni endothelin-converting enzyme-related 0.0024 0.0071 0.0071
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0213 0.0942 0.0942
Echinococcus multilocularis sex peptide receptor 0.0019 0.0047 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Schistosoma mansoni neuropeptide receptor 0.0019 0.0047 0.0047
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0055 0.0055
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0098 0.0412 0.6729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.002
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0213 0.0942 1
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0213 0.0942 0.0942
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Toxoplasma gondii peptidase family M13 protein 0.0098 0.0412 0.4334
Onchocerca volvulus Matrilysin homolog 0.0099 0.0415 0.2565
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni amine GPCR 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni zinc finger protein 0.0213 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0353
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0032 0.0032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0043 0.0043
Plasmodium falciparum plasmepsin III 0.0045 0.0167 0.1397
Plasmodium falciparum plasmepsin IX 0.0045 0.0167 0.1397
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0009 0.002
Plasmodium falciparum plasmepsin II 0.0081 0.0333 0.3242
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0047 0.0192
Echinococcus granulosus GPCR family 2 0.0015 0.0032 0.0032
Toxoplasma gondii aspartyl protease ASP3 0.0045 0.0167 0.1708
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0005 0.0005
Leishmania major glycerol uptake protein, putative 0.0213 0.0942 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0047 0.0047
Schistosoma mansoni coup transcription factor 0.0018 0.0043 0.0043
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0081 0.0333 0.2511
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0043 0.0043
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0213 0.0942 0.0942
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0013
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0047 0.0047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0047 0.0192
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0043 0.0043
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0043 0.0043
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0605 0.4781
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0043 0.0043
Brugia malayi neuropeptide F receptor 0.0019 0.0047 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0109
Loa Loa (eye worm) carboxylesterase 0.0012 0.0016 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Loa Loa (eye worm) matrixin family protein 0.0108 0.0456 0.0456
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0213 0.0942 0.0942
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0043 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0043 0.018
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0047 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0068 0.0424
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0213 0.0942 0.0942
Brugia malayi diacylglycerol acyltransferase 0.0213 0.0942 0.3895
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0043 0.0268
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0047 0.0047
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0074 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0535 0.2418 0.2418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0043 0.018
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0077 0.0724
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0081
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0047 0.0047
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0047 0.0047
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0213 0.0942 1
Onchocerca volvulus 0.0019 0.0047 0.0288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0186 0.0769
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0259 0.2677
Loa Loa (eye worm) acetylcholinesterase 1 0.007 0.0285 0.0285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0043 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0043 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0047 0.0047
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0153 0.1563
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0213 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0026 0.0079 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0047 0.0047
Echinococcus granulosus bloom syndrome protein 0.002 0.0055 0.0055
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0047 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0047 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0282
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0259 0.0259
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0213 0.0942 0.0942
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0043 0.0043
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0213 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.213 0.213
Echinococcus granulosus lamin dm0 0.0026 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Mycobacterium leprae probable zinc metalloprotease 0.0098 0.0412 0.6411
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0043 0.0043
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0019 0.0047 0.0288
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0041 0.0427
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0166
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0041 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0047 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1131 0.8826
Schistosoma mansoni ephrin receptor 0.0064 0.0254 0.0254
Echinococcus granulosus Solute carrier family 22 5 0.1016 0.4629 0.4629
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0942 0.7329
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0213 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0166
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.1131 0.1131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0186 0.0769
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0124 0.0859
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0077 0.0742
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0189 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0032 0.0032
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0091 0.0091
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0055 0.0158
Onchocerca volvulus 0.0019 0.0047 0.0288
Echinococcus granulosus o acyltransferase membrane bound domain 0.0213 0.0942 0.0942
Leishmania major glycerol uptake protein, putative 0.0213 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0016 0.0016
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus granulosus g protein coupled receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0047 0.0047
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0136 0.0136
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0596 0.0596
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0047 0.0192
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0167 0.1397
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0213 0.0942 0.0942
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0012 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0043 0.0043
Echinococcus multilocularis lamin dm0 0.0026 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0213 0.0942 0.0942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0016 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0213 0.0942 0.0942
Brugia malayi Matrixin family protein 0.0044 0.0166 0.0685
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0259 0.2677
Brugia malayi CXXC zinc finger family protein 0.0028 0.0091 0.0378
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0047 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0047 0.0047
Echinococcus granulosus somatostatin receptor 0.0019 0.0047 0.0047
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0259 0.1071
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0167 0.0691
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Schistosoma mansoni amine GPCR 0.0019 0.0047 0.0047
Brugia malayi Matrixin family protein 0.0108 0.0456 0.1885
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0043 0.018
Onchocerca volvulus 0.0045 0.0167 0.1032
Trypanosoma cruzi glycerol uptake protein, putative 0.0213 0.0942 1
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0047 0.0192
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0615 0.2543
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0168 0.0168
Brugia malayi hypothetical protein 0.0016 0.0036 0.0148
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0224 0.2315
Schistosoma mansoni amine GPCR 0.0019 0.0047 0.0047
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0047 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0043 0.0043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0047 0.0192
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0055 0.0229
Schistosoma mansoni hypothetical protein 0.0166 0.0725 0.0725
Echinococcus granulosus acetylcholinesterase 0.007 0.0285 0.0285
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0055 0.0209
Onchocerca volvulus 0.0019 0.0047 0.0288
Loa Loa (eye worm) acetyltransferase 0.0142 0.0615 0.0615
Brugia malayi MBOAT family protein 0.0213 0.0942 0.3895
Loa Loa (eye worm) TK/EPH protein kinase 0.0081 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0054 0.021 0.021
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0012 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0068 0.0478
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0068 0.0478
Echinococcus granulosus g protein coupled receptor 0.0019 0.0047 0.0047
Schistosoma mansoni biogenic amine receptor 0.0019 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0026 0.0079 0.0079
Loa Loa (eye worm) carboxylesterase 0.007 0.0285 0.0285
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0285 0.0285
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0055 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0043 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0055 0.0312
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0066
Echinococcus multilocularis GPCR, family 2 0.0015 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0259 0.2457
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0942 0.7329
Loa Loa (eye worm) hypothetical protein 0.0073 0.0295 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0012 0.0012
Loa Loa (eye worm) zinc metallopeptidase 4 0.0024 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0074 0.0302 0.0302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Echinococcus granulosus acetylcholinesterase 0.007 0.0285 0.0285
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0167 0.1708
Onchocerca volvulus 0.0063 0.0251 0.1553
Onchocerca volvulus 0.0026 0.0083 0.0512
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0043 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0168
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0047 0.0047
Entamoeba histolytica hypothetical protein, conserved 0.0213 0.0942 0.7347
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0167
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0213 0.0942 0.0942
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0047 0.0047
Brugia malayi Peptidase family M13 containing protein 0.0098 0.0412 0.1705
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0353
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0047 0.0047
Entamoeba histolytica recQ family helicase, putative 0.002 0.0055 0.0377
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0168 0.0168
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0047 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Onchocerca volvulus 0.0019 0.0047 0.0288
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0073 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0074 0.0302 0.0302
Leishmania major hypothetical protein, conserved 0.0213 0.0942 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0043 0.018
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0047 0.0047
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0213 0.0942 0.7347
Brugia malayi ORL1-like opioid receptor 0.0019 0.0047 0.0192
Plasmodium vivax aspartyl protease, putative 0.0045 0.0167 0.1708
Echinococcus multilocularis somatostatin receptor 0.0019 0.0047 0.0047
Schistosoma mansoni cathepsin D (A01 family) 0.0173 0.0757 0.0757
Echinococcus granulosus lamin 0.0026 0.0083 0.0083
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0043 0.0043
Echinococcus granulosus neuroligin 0.0012 0.0016 0.0016
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0162 0.0705 0.0705
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0353
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Echinococcus multilocularis cpg binding protein 0.003 0.0099 0.0099
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0047 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0168 0.0168
Onchocerca volvulus 0.0019 0.0047 0.0288
Brugia malayi Carboxylesterase family protein 0.007 0.0285 0.1179
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0043 0.0043
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0081 0.0333 0.0333
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0136 0.0136
Echinococcus multilocularis carboxylesterase 5A 0.007 0.0285 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0032 0.0134
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0167 0.0167
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0134 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0043 0.018
Loa Loa (eye worm) hypothetical protein 0.0098 0.0412 0.0412
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0213 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0074 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0213 0.0942 0.0942
Brugia malayi MBOAT family protein 0.0213 0.0942 0.3895
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0041 0.0361
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0259 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0068 0.0424
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0083 0.0083
Entamoeba histolytica vacuolar protein sorting 26 0.0213 0.0942 0.7347
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0124 0.0859
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0009 0.002
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0213 0.0942 0.0942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Schistosoma mansoni hypothetical protein 0.0026 0.0079 0.0079
Echinococcus granulosus neuropeptide s receptor 0.0472 0.213 0.213
Plasmodium vivax aspartyl protease, putative 0.0045 0.0167 0.1708
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0077 0.0395
Leishmania major glycerol uptake protein, putative 0.0213 0.0942 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0032 0.0134
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0012 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0068 0.0478
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0055 0.0513
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0047 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.035
Plasmodium falciparum plasmepsin IV 0.0081 0.0333 0.3242
Entamoeba histolytica recQ family DNA helicase 0.001 0.0009 0.0014
Plasmodium falciparum plasmepsin VI 0.0081 0.0333 0.3242
Onchocerca volvulus 0.0028 0.0091 0.0565
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hhat protein 0.0213 0.0942 0.0942
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0005 0.0005
Trypanosoma brucei glycerol uptake protein, putative 0.0213 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0412 0.0412
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0047 0.0047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0047 0.0047
Plasmodium vivax plasmepsin IV, putative 0.0081 0.0333 0.3486
Onchocerca volvulus 0.0019 0.0047 0.0288
Brugia malayi Melatonin receptor type 1A 0.0019 0.0047 0.0192
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0016 0.0016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) matrixin family protein 0.0099 0.0415 0.0415
Schistosoma mansoni memapsin-2 (A01 family) 0.0446 0.2011 0.2011
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0036 0.0036
Brugia malayi ecdysteroid receptor 0.0018 0.0043 0.018
Echinococcus multilocularis neuroligin 0.0012 0.0016 0.0016
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0047 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0047 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0043 0.0043
Echinococcus multilocularis serotonin receptor 0.0019 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0213 0.0942 0.7347
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.3237 0.3237
Plasmodium falciparum plasmepsin X 0.0045 0.0167 0.1397
Brugia malayi Serotonin receptor 0.0019 0.0047 0.0192
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0047 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0043 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0055 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0043 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0068 0.0424
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0019 0.0047 0.0288
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0026 0.0109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0115 0.0115
Onchocerca volvulus 0.0026 0.0083 0.0512
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0071 0.0071
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0043 0.018
Onchocerca volvulus 0.0019 0.0047 0.0288
Loa Loa (eye worm) hypothetical protein 0.0074 0.0302 0.0302
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1279 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0213 0.0942 0.0942
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1279 1
Onchocerca volvulus Matrilysin homolog 0.0044 0.0166 0.1025
Onchocerca volvulus 0.0213 0.0942 0.5823
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0136 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.0942 0.7329
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0068 0.0886
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0047 0.0192
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0213 0.0942 0.0942
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0071 0.0071
Echinococcus granulosus allatostatin A receptor 0.0019 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.0016 0.0036 0.0151
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0047 0.0047
Schistosoma mansoni amine GPCR 0.0019 0.0047 0.0047
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0213 0.0942 0.0942
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0024 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Schistosoma mansoni neuropeptide receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0019 0.0047 0.0288
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1131 0.8826
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0043 0.0043
Brugia malayi neuropeptide F receptor 0.0019 0.0047 0.0192
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.3237 0.3237
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0005 0.0005
Schistosoma mansoni neprilysin-2 (M13 family) 0.005 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0047 0.0047
Schistosoma mansoni histamine h1 receptor 0.0019 0.0047 0.0047
Echinococcus granulosus microtubule associated protein 2 0.0713 0.3237 0.3237
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0063 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0068
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0081 0.0333 0.0333
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0047 0.0047
Schistosoma mansoni opsin-like receptor 0.0019 0.0047 0.0047
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0213 0.0942 0.0942
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0043 0.0043
Echinococcus multilocularis endothelin converting enzyme 1 0.0098 0.0412 0.0412
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0016 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0047 0.0047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0259 0.1978
Schistosoma mansoni neprilysin 0.0026 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0043 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Schistosoma mansoni biogenic amine receptor 0.0019 0.0047 0.0047
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0036 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0032
Trichomonas vaginalis porcupine, putative 0.0213 0.0942 0.7329
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0032 0.0032
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0068 0.0424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0168 0.0168
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0047 0.0288
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.1131 0.4677
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0098 0.0412 0.1705
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi G-protein coupled receptor 0.0019 0.0047 0.0192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0047 0.0047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Brugia malayi GnHR receptor homolog 0.0019 0.0047 0.0192
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0055 0.0495
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) matrix metalloproteinase 0.0044 0.0166 0.0166
Onchocerca volvulus 0.0044 0.0166 0.1025
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.0007
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0213 0.0942 0.0942
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0043 0.0268
Loa Loa (eye worm) hypothetical protein 0.036 0.1617 0.1617
Brugia malayi Dopamine receptor protein 2 0.0019 0.0047 0.0192
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0063 0.0251 0.155
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0043 0.0043
Onchocerca volvulus 0.0012 0.0016 0.0099
Onchocerca volvulus 0.0019 0.0047 0.0288
Schistosoma mansoni hypothetical protein 0.0026 0.0079 0.0079
Echinococcus granulosus fmrfamide receptor 0.0019 0.0047 0.0047
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0153 0.1563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0026 0.0079 0.0079
Onchocerca volvulus 0.0023 0.0068 0.0421
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0729 0.5642
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Brugia malayi nuclear receptor RXR 0.0009 0.0005 0.0019
Trypanosoma cruzi glycerol uptake protein, putative 0.0213 0.0942 1
Brugia malayi Serotonin receptor 0.0019 0.0047 0.0192
Brugia malayi cancer related gene-liver 1 0.036 0.1617 0.669
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0047 0.0047
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0036 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0213 0.0942 0.0942
Brugia malayi hypothetical protein 0.0045 0.0167 0.0691
Brugia malayi hypothetical protein 0.0012 0.0016 0.0066
Trypanosoma cruzi GUP1, putative 0.0213 0.0942 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0167
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0047 0.0047
Brugia malayi putative neuropeptide receptor 0.0019 0.0047 0.0192
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0137 0.1069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0043 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0077 0.0445
Loa Loa (eye worm) hypothetical protein 0.0073 0.0295 0.0295
Schistosoma mansoni Nep2 peptidase (M13 family) 0.005 0.0189 0.0189
Onchocerca volvulus Alkaline ceramidase homolog 0.036 0.1617 1
Onchocerca volvulus 0.0049 0.0185 0.1142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni opsin-like receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0047 0.0047
Schistosoma mansoni myosin xvIII 0.0019 0.0047 0.0047
Trypanosoma brucei glycerol uptake protein, putative 0.0213 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0019 0.0047 0.0288
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0068
Brugia malayi MBOAT family protein 0.0213 0.0942 0.3895
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1256 0.5734 0.5734
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0168 0.0168
Brugia malayi Matrixin family protein 0.0044 0.0166 0.0685
Onchocerca volvulus 0.0019 0.0047 0.0288
Onchocerca volvulus 0.0012 0.0016 0.0099
Echinococcus granulosus neuropeptide receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) carboxylesterase 0.0012 0.0016 0.0016
Loa Loa (eye worm) hhat protein 0.0213 0.0942 0.0942
Echinococcus multilocularis bloom syndrome protein 0.002 0.0055 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.035
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0043 0.018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0068
Schistosoma mansoni biogenic amine receptor 0.0019 0.0047 0.0047
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0054 0.021 0.087
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0047 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1131 0.8826
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0083
Onchocerca volvulus 0.0019 0.0047 0.0288
Loa Loa (eye worm) MBOAT family protein 0.0213 0.0942 0.0942
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.002 0.002
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0213 0.0942 0.0942
Treponema pallidum alginate O-acetylation protein (algI) 0.0213 0.0942 0.7344
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.077 0.5969
Echinococcus granulosus geminin 0.0166 0.0725 0.0725
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0036 0.0292
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0077 0.0742
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0026 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0044 0.0166 0.0166
Brugia malayi Matrixin family protein 0.0044 0.0166 0.0685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0068 0.0886
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0043 0.0043
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0068 0.0424
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0047 0.0047
Schistosoma mansoni DNA helicase recq1 0.002 0.0055 0.0055
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0016 0.0016
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0259 0.0259
Echinococcus granulosus serotonin receptor 0.0019 0.0047 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0047 0.0047
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0189 0.0189
Brugia malayi G protein-coupled receptor 0.0019 0.0047 0.0192
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0016 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0005 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0152 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Brugia malayi RE15519p 0.0019 0.0047 0.0192
Onchocerca volvulus 0.0019 0.0047 0.0288
Brugia malayi Dopamine receptor protein 1 0.0019 0.0047 0.0192
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0047 0.0047
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0047 0.0047
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1279 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Schistosoma mansoni acetylcholinesterase 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0045 0.0167 0.1032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0043 0.018
Brugia malayi hypothetical protein 0.0535 0.2418 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0054 0.021 0.2648
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0066
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0032
Brugia malayi sulfakinin receptor protein 0.0019 0.0047 0.0192
Loa Loa (eye worm) hypothetical protein 0.007 0.0285 0.0285
Plasmodium vivax aspartyl protease, putative 0.0045 0.0167 0.1708
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0167 0.0691
Onchocerca volvulus 0.0019 0.0047 0.0288
Mycobacterium ulcerans hydrolase 0.0054 0.021 0.1577
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0047 0.0047
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0615 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0043 0.018
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0016 0.0016
Echinococcus granulosus cpg binding protein 0.003 0.0099 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0068 0.035
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0098 0.0412 0.0412
Mycobacterium ulcerans hypothetical protein 0.0023 0.0068 0.0424
Loa Loa (eye worm) hypothetical protein 0.0049 0.0186 0.0186
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0043 0.018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0047 0.0047
Brugia malayi Dopamine receptor 0.0019 0.0047 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1279 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.077 0.5969
Schistosoma mansoni gliotactin 0.0012 0.0016 0.0016
Brugia malayi Matrixin family protein 0.0044 0.0166 0.0685
Plasmodium falciparum plasmepsin VII 0.0045 0.0167 0.1397
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0047 0.0047
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0047 0.0047
Loa Loa (eye worm) MBOAT family protein 0.0213 0.0942 0.0942
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0071 0.0071
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0026 0.0026
Echinococcus multilocularis serotonin receptor 0.0019 0.0047 0.0047
Leishmania major glycerol uptake protein, putative 0.0213 0.0942 1
Echinococcus multilocularis acetylcholinesterase 0.007 0.0285 0.0285
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0055 0.0229
Schistosoma mansoni neuropeptide receptor 0.0019 0.0047 0.0047
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0041 0.0204
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0055 0.0055
Schistosoma mansoni adenoreceptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.1971 0.9019 0.9019
Schistosoma mansoni intermediate filament proteins 0.0026 0.0083 0.0083
Toxoplasma gondii hypothetical protein 0.0213 0.0942 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0228 0.1011 0.1011
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0605 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0068 0.0282
Brugia malayi MBOAT family protein 0.0213 0.0942 0.3895
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0237 0.0237
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0167 0.0167
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0153 0.1563
Echinococcus multilocularis acetylcholinesterase 0.007 0.0285 0.0285
Brugia malayi larval opioid receptor 0.0019 0.0047 0.0192
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0153 0.0153
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0016 0.0016
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0729 0.4505
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0043 0.018
Schistosoma mansoni opsin-like receptor 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0074 0.0302 0.0302
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0213 0.0942 0.7347
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0047 0.0047
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0047 0.0047
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0213 0.0942 0.7347
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1279 1
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.213 0.213
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0005 0.0019
Echinococcus granulosus o acyltransferase membrane bound domain 0.0213 0.0942 0.0942
Brugia malayi hypothetical protein 0.0019 0.0047 0.0192
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0213 0.0942 0.0942
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0032 0.0032
Brugia malayi Pepsin A precursor 0.0045 0.0167 0.0691
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.002 0.002
Brugia malayi Hemopexin family protein 0.0063 0.0251 0.1039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0043 0.0268
Loa Loa (eye worm) hypothetical protein 0.0033 0.0115 0.0115
Mycobacterium ulcerans zinc metalloprotease 0.0098 0.0412 0.3217
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0213 0.0942 0.0942
Brugia malayi Hhat protein 0.0213 0.0942 0.3895
Schistosoma mansoni cathepsin D (A01 family) 0.0173 0.0757 0.0757
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) peptidase family M13 containing protein 0.0073 0.0295 0.0295
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0024 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0081 0.0333 0.0333
Brugia malayi hypothetical protein 0.0045 0.0167 0.0691

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Agonist activity at human dopamine D2long receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP accumulation by bioluminescence assay ChEMBL. 21388142
Activity (functional) Agonist activity at human dopamine D2long receptor expressed in CHO cells assessed as induction of [3H]thymidine incorporation after 2 hrs ChEMBL. 21388142
EC50 (functional) = 51 nM Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting ChEMBL. 21388142
Ki (binding) = 6.3 nM Displacement of [3H]7-OH-DPAT from human dopamine D3 receptor expressed in CHO cells after 60 mins ChEMBL. 21388142
Ki (binding) = 15 nM Displacement of [3H]spiperone from human dopamine D3 receptor S5.46A mutant expressed in HEK293 cells after 60 mins ChEMBL. 21388142
Ki (binding) = 15 nM Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins ChEMBL. 21388142
Ki (binding) = 19 nM Displacement of [3H]spiperone from wild type human dopamine D3 receptor expressed in HEK293 cells after 60 mins ChEMBL. 21388142
Ki (binding) = 43 nM Displacement of [3H]spiperone from human dopamine D3 receptor S6.55A mutant expressed in HEK293 cells after 60 mins ChEMBL. 21388142
Ki (binding) = 49 nM Displacement of [3H]7-OH-DPAT from human dopamine D2long receptor expressed in CHO cells after 60 mins ChEMBL. 21388142
Ki (binding) = 240 nM Displacement of [3H]spiperone from human dopamine D3 receptor S5.42A mutant expressed in HEK293 cells after 60 mins ChEMBL. 21388142
Ki (binding) = 300 nM Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins ChEMBL. 21388142
Ki (binding) = 1400 nM Displacement of [3H]spiperone from human dopamine D3 receptor D3.32E mutant expressed in HEK293 cells after 60 mins ChEMBL. 21388142
Ki (binding) = 3700 nM Displacement of [3H]spiperone from human dopamine D3 receptor V2.61F mutant expressed in HEK293 cells after 60 mins ChEMBL. 21388142
Ratio EC50 (functional) = 80 Ratio of EC50 for human dopamine D2long receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation to EC50 for human dopamine D2long receptor expressed in CHO cells assessed as induction of [3H]thymidine incorporation ChEMBL. 21388142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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