Detailed information for compound 1530178

Basic information

Technical information
  • TDR Targets ID: 1530178
  • Name: [2-(cyclopentylamino)-2-oxo-1-pyridin-2-yleth yl] thiophene-2-carboxylate
  • MW: 330.401 | Formula: C17H18N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccn1)OC(=O)c1cccs1)NC1CCCC1
  • InChi: 1S/C17H18N2O3S/c20-16(19-12-6-1-2-7-12)15(13-8-3-4-10-18-13)22-17(21)14-9-5-11-23-14/h3-5,8-12,15H,1-2,6-7H2,(H,19,20)
  • InChiKey: WDAZZVKMJSRDOS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(cyclopentylamino)-2-oxo-1-(2-pyridyl)ethyl] thiophene-2-carboxylate
  • 2-thiophenecarboxylic acid [2-(cyclopentylamino)-2-oxo-1-(2-pyridyl)ethyl] ester
  • thiophene-2-carboxylic acid [2-(cyclopentylamino)-2-keto-1-(2-pyridyl)ethyl] ester
  • [2-(cyclopentylamino)-2-oxo-1-pyridin-2-yl-ethyl] thiophene-2-carboxylate
  • SMR000119929
  • ASN 07460763
  • Thiophene-2-carboxylic acid cyclopentylcarbamoyl-pyridin-2-yl-methyl ester
  • MLS000122552

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax amine transporter, putative 0.0275 0.0547 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0019 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0038 0.0039
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0035 0.0609
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Echinococcus granulosus tm gpcr rhodopsin 0.0536 0.1088 0.1173
Echinococcus multilocularis serotonin receptor 0.0021 0.0019 0.0019
Echinococcus granulosus synaptic vesicular amine transporter 0.4258 0.8808 0.9509
Brugia malayi Dopamine receptor protein 2 0.0021 0.0019 0.0019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0496 0.0494
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0016
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0035 0.0609
Loa Loa (eye worm) hypothetical protein 0.0157 0.0303 0.0301
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0039 0.0057 0.0056
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0155 0.0155
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0038 0.0344
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0038 0.0661
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0275 0.0547 0.059
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0015 0.024
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0153 0.0295 0.0293
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi jmjC domain containing protein 0.0093 0.017 0.0169
Schistosoma mansoni amine GPCR 0.0021 0.0019 0.0021
Leishmania major squalene synthase, putative 0.1043 0.2139 0.2139
Loa Loa (eye worm) hypothetical protein 0.0236 0.0467 0.0465
Leishmania major hypothetical protein, conserved 0.0325 0.0651 0.0651
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0085 0.0152 0.0152
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Schistosoma mansoni hypothetical protein 0.005 0.008 0.0086
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0008 0.0008
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0026 0.0024
Schistosoma mansoni acetylcholine receptor-related 0.0039 0.0057 0.0062
Schistosoma mansoni adenoreceptor 0.0021 0.0019 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Brugia malayi Serotonin receptor 0.0021 0.0019 0.0019
Onchocerca volvulus 0.0085 0.0152 0.0144
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni glutamate receptor NMDA 0.0023 0.0024 0.0025
Brugia malayi Sodium:neurotransmitter symporter family protein 0.162 0.3337 0.3337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0019 0.0021
Echinococcus multilocularis serotonin receptor 0.0021 0.0019 0.0019
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0021 0.0216
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0038 0.0038
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.0568 1
Echinococcus granulosus sphingosine kinase 1 0.0152 0.0292 0.0313
Echinococcus multilocularis peregrin 0.0033 0.0044 0.0045
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0039 0.0056 0.0633
Brugia malayi Cation transporter family protein 0.0085 0.0152 0.0152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0152 0.0152
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0019 0.0019
Echinococcus granulosus GPCR family 2 0.005 0.008 0.0084
Schistosoma mansoni hypothetical protein 0.005 0.008 0.0086
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0275 0.0547 0.0588
Schistosoma mansoni hypothetical protein 0.0325 0.0651 0.0702
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0275 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.02 0.0198
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0019 0.0021
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0008 0.0006
Loa Loa (eye worm) solute carrier family 6 member 4 0.162 0.3337 0.3335
Loa Loa (eye worm) hypothetical protein 0.162 0.3337 0.3335
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0196 0.0383 0.7223
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0038 0.0661
Onchocerca volvulus 0.0046 0.0071 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0019 0.0019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0085 0.0152 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Onchocerca volvulus Putative nachr subunit 0.0153 0.0295 0.0298
Trichomonas vaginalis dullard protein, putative 0.0012 0.0002 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) GABA receptor subunit 0.0046 0.0071 0.0069
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0026 0.0026
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0038 0.0661
Loa Loa (eye worm) acetyltransferase 0.0175 0.0339 0.0338
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0046 0.0071 0.0076
Echinococcus multilocularis sphingosine kinase 1 0.0152 0.0292 0.0313
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0053 0.0559
Echinococcus granulosus sodium and chloride dependent glycine 0.0275 0.0547 0.0588
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0015
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0053 0.0584
Onchocerca volvulus 0.0039 0.0057 0.0041
Schistosoma mansoni biogenic amine receptor 0.0021 0.0019 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0303 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.01 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0225 0.0223
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0152 0.0292 0.029
Echinococcus granulosus nAChR subunit 0.0085 0.0152 0.0162
Echinococcus granulosus dna polymerase kappa 0.0019 0.0016 0.0015
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0019 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor 0.0021 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0218 0.0429 0.6502
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0508 0.5323
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Onchocerca volvulus 0.0039 0.0057 0.0041
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0046 0.0071 0.0071
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0035 0.0038
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0038 0.04
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0153 0.0295 0.0316
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4833 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0038 0.0038
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0039 0.0056 0.0055
Onchocerca volvulus 0.0085 0.0152 0.0144
Schistosoma mansoni biogenic amine receptor 0.0021 0.0019 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0152 0.0162
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0053 0.0053
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0026 0.0026
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0026 0.0025
Toxoplasma gondii hypothetical protein 0.0275 0.0547 1
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0008 0.0006
Schistosoma mansoni glutamate receptor NMDA 0.0073 0.0127 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0152 0.0162
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0275 0.0547 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0275 0.0547 0.0545
Brugia malayi Dopamine receptor 0.0021 0.0019 0.0019
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0021 0.0019 0.0021
Trypanosoma brucei unspecified product 0.0013 0.0004 0.0004
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0019 0.0019
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0071 0.0076
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0275 0.0547 0.059
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0085 0.0152 0.0162
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0026 0.0026
Brugia malayi G-protein coupled receptor 0.0021 0.0019 0.0019
Echinococcus granulosus Squalene phytoene synthase 0.0325 0.0651 0.07
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0016 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.01 0.0105
Echinococcus multilocularis sodium and chloride dependent glycine 0.0275 0.0547 0.0588
Brugia malayi G protein-coupled receptor 0.0021 0.0019 0.0019
Brugia malayi Bromodomain containing protein 0.0033 0.0044 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0325 0.0331
Treponema pallidum sodium- and chloride- dependent transporter 0.162 0.3337 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0275 0.0547 0.0588
Echinococcus granulosus dna polymerase eta 0.0019 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0021
Schistosoma mansoni amine GPCR 0.0021 0.0019 0.0021
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0152 0.0164
Plasmodium falciparum amino acid transporter, putative 0.0275 0.0547 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0019 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0019 0.0021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0568 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0085 0.0152 0.0162
Schistosoma mansoni survival motor neuron protein 0.0048 0.0076 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Onchocerca volvulus 0.0275 0.0547 0.0571
Plasmodium vivax hypothetical protein, conserved 0.0275 0.0547 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0019 0.0019
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0508 0.0507
Entamoeba histolytica hypothetical protein, conserved 0.0152 0.0292 0.5144
Brugia malayi G-protein coupled receptor 0.0021 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0275 0.0547 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0303 0.0303
Plasmodium falciparum transporter, putative 0.0275 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0196 0.0383 0.5786
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0071 0.0071
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.0057 0.006
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0024 0.0023
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0053 0.0584
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0019 0.0019
Echinococcus multilocularis glutamate receptor 2 0.0023 0.0024 0.0023
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.008 0.0084
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0019 0.0019
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0275 0.0547 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni DNA polymerase eta 0.0019 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.012 0.0225 0.0223
Toxoplasma gondii thioredoxin reductase 0.0086 0.0155 0.2802
Mycobacterium ulcerans hypothetical protein 0.0152 0.0292 0.4347
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0019 0.0019
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0085 0.0152 0.0152
Echinococcus granulosus fmrfamide receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0153 0.0295 0.0293
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0196 0.0383 0.5786
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0085 0.0152 0.0152
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0155 0.2802
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0152 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0019 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0019 0.0019
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0058 0.0061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0071 0.0071
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0085 0.0152 0.0162
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0467 0.0501
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0153 0.0295 0.0316
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0019 0.0021
Plasmodium falciparum thioredoxin reductase 0.0086 0.0155 0.2802
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Brugia malayi Cation transporter family protein 0.0085 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.4833 1 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.0021 0.0019 0.0019
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0085 0.0152 0.0152
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0048 0.0051
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0019 0.0019
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Plasmodium vivax SET domain protein, putative 0.0059 0.01 0.1791
Brugia malayi Latrophilin receptor protein 2 0.005 0.008 0.0079
Schistosoma mansoni neuropeptide receptor 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Echinococcus multilocularis somatostatin receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0026 0.0026
Schistosoma mansoni vesicular amine transporter 0.4258 0.8808 0.9509
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0325 0.0651 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0856 0.1752 0.1891
Echinococcus granulosus nAChR subunit 0.0046 0.0071 0.0074
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.0057 0.006
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0085 0.0152 0.015
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0026 0.0026
Onchocerca volvulus 0.0159 0.0306 0.031
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.4477 0.9262 0.9262
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) glutathione reductase 0.0086 0.0155 0.0153
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0076 0.0076
Trypanosoma brucei squalene synthase, putative 0.1043 0.2139 0.2139
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0002 0.0002
Trichomonas vaginalis chaperonin, putative 0.0024 0.0026 0.027
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.02 0.0199
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0046 0.0071 0.0071
Brugia malayi vesicular acetylcholine transporter unc-17 0.4477 0.9262 0.9262
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0023 0.0024 0.0023
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Echinococcus multilocularis NMDA receptor 0.0015 0.0008 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0048 0.0051
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.162 0.3337 0.3602
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0016
Schistosoma mansoni opsin-like receptor 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Onchocerca volvulus Alhambra homolog 0.0028 0.0035 0.0017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0152 0.0162
Onchocerca volvulus 0.0275 0.0547 0.0571
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0038 0.0344
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0019 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0057 0.0062
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0303 0.0301
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0159 0.0306 0.0304
Echinococcus granulosus zinc finger transcription factor gli2 0.031 0.0619 0.0667
Schistosoma mansoni hypothetical protein 0.0856 0.1752 0.1891
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.0057 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0019 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0218 0.0429 0.6502
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0035 0.0034
Echinococcus multilocularis sodium and chloride dependent glycine 0.0275 0.0547 0.0588
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.4258 0.8808 0.8808
Brugia malayi Thioredoxin reductase 0.0086 0.0155 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0021 0.0216
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0053 1
Brugia malayi neuropeptide F receptor 0.0021 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus granulosus somatostatin receptor 0.0021 0.0019 0.0019
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0011 0.0012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0196 0.0383 0.5786
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.4477 0.9262 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.017 0.0181
Echinococcus granulosus glycine receptor subunit beta 0.0085 0.0152 0.0162
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0026 0.0028
Echinococcus granulosus serotonin receptor 0.0021 0.0019 0.0019
Trypanosoma cruzi squalene synthase, putative 0.1043 0.2139 0.2139
Echinococcus multilocularis glycine receptor subunit beta 0.0085 0.0152 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0019 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0344 0.3604
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0053 0.0941
Brugia malayi Dopamine receptor protein 1 0.0021 0.0019 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0152 0.0162
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0053 0.0941
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0016
Echinococcus multilocularis geminin 0.0856 0.1752 0.1889
Echinococcus multilocularis nAChR subunit 0.0046 0.0071 0.0074
Schistosoma mansoni opsin-like receptor 0.0021 0.0019 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Brugia malayi PHD-finger family protein 0.0028 0.0035 0.0035
Trypanosoma brucei trypanothione reductase 0.0086 0.0155 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0035 0.0609
Echinococcus granulosus g protein coupled receptor 0.0021 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0508 0.5323
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0026 0.0417
Schistosoma mansoni vesicular acetylcholine transporter 0.4477 0.9262 1
Echinococcus multilocularis sex peptide receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Plasmodium falciparum glutathione reductase 0.0086 0.0155 0.2802
Toxoplasma gondii exonuclease III APE 0.0037 0.0053 0.0941
Echinococcus multilocularis zinc finger transcription factor gli2 0.031 0.0619 0.0667
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0026 0.0433
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0038 0.0661
Brugia malayi ORL1-like opioid receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) norepinephrine transporter 0.162 0.3337 0.3335
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0275 0.0547 0.059
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0019 0.0019
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Loa Loa (eye worm) acetylcholine receptor protein 0.0039 0.0057 0.0056
Leishmania major DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Schistosoma mansoni sphingosine kinase A B 0.0152 0.0292 0.0315
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.0196 0.0383 0.5786
Brugia malayi hypothetical protein 0.0275 0.0547 0.0547
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0038 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.01 0.0107
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0496 0.0496
Schistosoma mansoni histamine h1 receptor 0.0021 0.0019 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0053 0.0559
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0085 0.0152 0.015
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0057 0.0062
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0019 0.0018
Schistosoma mansoni myosin xvIII 0.0021 0.0019 0.0021
Echinococcus granulosus nmda type glutamate receptor 0.0054 0.0088 0.0092
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0019 0.0019
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0008 0.0007
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Onchocerca volvulus 0.0275 0.0547 0.0571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.0156 0.0166
Leishmania major hypothetical protein, conserved 0.0012 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0021 0.0019 0.0021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0568 1
Onchocerca volvulus 0.0048 0.0076 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0275 0.0547 0.059
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0008 0.0008
Plasmodium vivax glutathione reductase, putative 0.0086 0.0155 0.2802
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0039 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.162 0.3337 0.3335
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0083 0.0087
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0218 0.0429 1
Leishmania major trypanothione reductase 0.0086 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.247 0.51 0.5099
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.0156 0.0166
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0026 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0265 0.3924
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0019 0.0019
Echinococcus multilocularis dna polymerase eta 0.0019 0.0016 0.0015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.008 0.0084
Echinococcus granulosus hypothetical protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Echinococcus granulosus orexin receptor type 2 0.0021 0.0019 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0019 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0547 0.0547
Schistosoma mansoni nAChR subunit 0.0039 0.0057 0.0062
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0026 0.0028
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0019 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0152 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Echinococcus granulosus geminin 0.0856 0.1752 0.1889
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Loa Loa (eye worm) hypothetical protein 0.0028 0.0035 0.0034
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0275 0.0547 0.059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.008 0.0079
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0083 0.087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0159 0.0306 0.033
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0074 0.1308
Entamoeba histolytica hypothetical protein 0.0046 0.0071 0.1251
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0021
Echinococcus granulosus vesicular acetylcholine transporter 0.4477 0.9262 1
Brugia malayi MH2 domain containing protein 0.012 0.0225 0.0224
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0026 0.0433
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0038 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0016 0.0171
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0002 0.0023
Brugia malayi Zinc finger, C2H2 type family protein 0.031 0.0619 0.0619
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0508 0.5323
Brugia malayi glutathione reductase 0.0086 0.0155 0.0155
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0053 0.0055
Onchocerca volvulus 0.0159 0.0306 0.031
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0467 0.0501
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0019 0.0019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0218 0.0429 0.6502
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0108 0.02 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Schistosoma mansoni hypothetical protein 0.005 0.008 0.0086
Plasmodium falciparum glutathione reductase 0.003 0.0038 0.0661
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0019 0.0021
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0083 0.087
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) RecQ helicase 0.0021 0.0021 0.0019
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0275 0.0547 0.059
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.005 0.008 0.0086
Giardia lamblia PHD finger protein 15 0.0028 0.0035 0.0587
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0153 0.0295 0.0316
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0085 0.0152 0.0164
Echinococcus granulosus glutamate NMDA receptor subunit 0.0073 0.0127 0.0135
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0039 0.0057 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Schistosoma mansoni ap endonuclease 0.0037 0.0053 0.0057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Brugia malayi larval opioid receptor 0.0021 0.0019 0.0019
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0039 0.0056 0.036
Mycobacterium tuberculosis Probable reductase 0.0196 0.0383 0.5786
Onchocerca volvulus 0.0472 0.0955 0.1012
Trypanosoma brucei unspecified product 0.0013 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0053 0.0053
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0008 0.0006
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0006 0.0075
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0472 0.0955 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0053 0.0052
Echinococcus granulosus serotonin transporter 0.162 0.3337 0.3601
Schistosoma mansoni sphingoid long chain base kinase 0.0152 0.0292 0.0315
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0019 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.0836 0.0835
Echinococcus multilocularis serotonin transporter 0.162 0.3337 0.3601
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0074 0.1323
Echinococcus multilocularis Squalene phytoene synthase 0.0325 0.0651 0.07
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0085 0.0152 0.0152
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0095 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0085 0.0152 0.0162
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0008 0.0006
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0019 0.0021
Leishmania major C-8 sterol isomerase-like protein 0.4833 1 1
Schistosoma mansoni ap endonuclease 0.0037 0.0053 0.0057
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0152 0.0152
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0016 0.0288
Loa Loa (eye worm) LGC-31 protein 0.0085 0.0152 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.01 0.0105
Loa Loa (eye worm) hypothetical protein 0.0059 0.01 0.0098
Echinococcus multilocularis nAChR subunit 0.0085 0.0152 0.0162
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0019 0.0019
Schistosoma mansoni nAChR subunit 0.0039 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0008 0.0008
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0039 0.0057 0.006
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0085 0.0152 0.0162
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.008 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0275 0.0547 1
Echinococcus granulosus g protein coupled receptor 0.0021 0.0019 0.0019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0024 0.0023
Onchocerca volvulus 0.0046 0.0071 0.0056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0152 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.01 0.0107
Onchocerca volvulus 0.0085 0.0152 0.0144
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0153 0.0295 0.0316
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0275 0.0547 0.0588
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0339 0.0339
Brugia malayi neuropeptide F receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0098 0.0096
Brugia malayi jmjC domain containing protein 0.0034 0.0048 0.0048
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0275 0.0547 0.0588
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0038 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0008 0.0007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0159 0.0306 0.0304
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0019 0.0018
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0021 0.002
Chlamydia trachomatis glutamine binding protein 0.0039 0.0056 0.036
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0023 0.0024 0.0023
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0019 0.0019
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Mycobacterium ulcerans phytoene synthase, CrtB 0.0325 0.0651 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0019 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0152 0.0152
Schistosoma mansoni amine GPCR 0.0021 0.0019 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor 0.0021 0.0019 0.0019
Schistosoma mansoni opsin-like receptor 0.0021 0.0019 0.0021
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0225 0.0223
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) serotonin transporter b 0.162 0.3337 0.3335
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0002 0.0023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0038 0.0038
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0054 0.0088 0.0092
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0085 0.0152 0.0162
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0159 0.0306 0.033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0547 0.0547
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0035 0.0036
Brugia malayi hypothetical protein 0.0236 0.0467 0.0466
Echinococcus granulosus allatostatin A receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0019 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.008 0.0084
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0019 0.0019
Echinococcus multilocularis synaptic vesicular amine transporter 0.4258 0.8808 0.9509
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0008 0.0006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0053 0.0906
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0019 0.0019
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0508 0.0508
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0046 0.0071 0.0076
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0083 0.1486
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0339 0.0364
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0002 0.0023
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0019 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Plasmodium falciparum thioredoxin reductase 0.003 0.0038 0.0661
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0152 0.0162
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0019 0.0019
Echinococcus granulosus sex peptide receptor 0.0021 0.0019 0.0019
Brugia malayi putative neuropeptide receptor 0.0021 0.0019 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.008 0.0084
Trypanosoma cruzi squalene synthase, putative 0.1043 0.2139 0.2139
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0006 0.0069
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0024 0.0023
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0152 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0019 0.0019
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus multilocularis glycine receptor subunit beta 0.0085 0.0152 0.0162
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0019 0.0021
Schistosoma mansoni amine GPCR 0.0021 0.0019 0.0021
Trypanosoma brucei unspecified product 0.0019 0.0016 0.0016
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0002 0.0023
Mycobacterium tuberculosis Conserved protein 0.0152 0.0292 0.4347
Brugia malayi Serotonin receptor 0.0021 0.0019 0.0019
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0019 0.0019
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0048 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0016 0.0171
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0026 0.0433
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0002 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0019 0.0019
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0155 0.2182
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0508 0.5323
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0019 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0152 0.0152
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0019 0.0019
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0153 0.0295 0.0294
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0275 0.0547 0.0545
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0019 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0053 0.0941
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0019 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0024 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.0015
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0085 0.0152 0.0162
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.0568 0.1605
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0152 0.0152
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0019 0.0021
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0085 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) zinc finger protein 0.031 0.0619 0.0618
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0019 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0019 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.01 0.0105
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0019 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0019 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0019 0.0019
Brugia malayi excitatory GABA receptor EXP-1A 0.0085 0.0152 0.0152
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0344 0.3604
Brugia malayi Pre-SET motif family protein 0.0059 0.01 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.162 0.3337 0.3335
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0026 0.0454
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0152 0.0164
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0019 0.0019
Schistosoma mansoni sodium/chloride dependent transporter 0.162 0.3337 0.3602
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.01 0.1791
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0019 0.0019
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0008 0.0006
Trichomonas vaginalis dullard protein, putative 0.0012 0.0002 0.0023
Schistosoma mansoni acetylcholine receptor subunit beta 0.0039 0.0057 0.0062
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0073 0.0127 0.0135
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0019 0.0019
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0039 0.0057 0.006
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0016
Echinococcus granulosus sodium and chloride dependent glycine 0.0275 0.0547 0.0588
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0038 0.0038
Loa Loa (eye worm) ACC-1 protein 0.0085 0.0152 0.015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0536 0.1088 0.1173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0275 0.0547 0.059
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0038 0.04
Echinococcus multilocularis vesicular acetylcholine transporter 0.4477 0.9262 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0083 0.1486
Loa Loa (eye worm) hypothetical protein 0.0325 0.0651 0.0649
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0035 0.0036
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0074 0.1274
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.01 0.0107
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0019 0.0021
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0053 0.0053
Echinococcus granulosus peregrin 0.0033 0.0044 0.0045
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0325 0.0651 0.0683
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0019 0.0021
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0019 0.0021
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0019 0.0019
Brugia malayi Pre-SET motif family protein 0.0415 0.0836 0.0836
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0016 0.0017
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0024 0.0023
Loa Loa (eye worm) ACC-1 protein 0.0085 0.0152 0.015
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0038 0.0637
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0085 0.0152 0.015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0019 0.0019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0019 0.0019
Brugia malayi AKH receptor 0.0021 0.0019 0.0019
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Echinococcus granulosus glutamate receptor 2 0.0023 0.0024 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0508 0.5323
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0085 0.0152 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0016 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0019 0.0021
Trypanosoma brucei C-8 sterol isomerase, putative 0.4833 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.0275 0.0547 0.0545
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0019 0.0021
Onchocerca volvulus 0.0059 0.01 0.0087
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0019 0.0021
Giardia lamblia DINP protein human, muc B family 0.0019 0.0016 0.0251
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0155 0.0153
Brugia malayi Abnormal catecholamine distribution protein 1 0.4258 0.8808 0.8808
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0008 0.0008
Plasmodium falciparum phd finger protein, putative 0.0028 0.0035 0.0609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0568 0.5943
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0265 0.3924
Schistosoma mansoni sodium-dependent amino acid transporter 0.0275 0.0547 0.059
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0339 0.0366
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0019 0.0019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0038 0.0344
Brugia malayi Melatonin receptor type 1A 0.0021 0.0019 0.0019
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0028 0.0035 0.0038
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0016 0.0015
Onchocerca volvulus 0.0159 0.0306 0.031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Onchocerca volvulus 0.162 0.3337 0.3589
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0019 0.0021
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0275 0.0547 0.0588
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0275 0.0547 0.059
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0275 0.0547 0.0588
Brugia malayi GnHR receptor homolog 0.0021 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0508 0.5323
Echinococcus multilocularis GPCR, family 2 0.005 0.008 0.0084
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Brugia malayi hypothetical protein 0.0039 0.0057 0.0057
Echinococcus granulosus jumonji domain containing protein 0.004 0.0058 0.0061
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0019 0.0019
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0026 0.027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0153 0.0295 0.0316
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0085 0.0152 0.0162
Schistosoma mansoni nAChR subunit 0.0085 0.0152 0.0164
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0275 0.0547 0.0547
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0038 0.0661
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0039 0.0056 0.0633
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0053 0.0046
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0038 0.0344
Echinococcus multilocularis nmda type glutamate receptor 0.0054 0.0088 0.0092
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0021 0.0019 0.0021
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0039 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0329 0.0353
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0008 0.0008
Brugia malayi RE15519p 0.0021 0.0019 0.0019
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0085 0.0152 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0008 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0057 0.0057
Echinococcus granulosus bloom syndrome protein 0.0021 0.0021 0.002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0152 0.0152
Trypanosoma cruzi phytoene synthase, putative 0.0325 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0325 0.3408
Schistosoma mansoni neuropeptide receptor 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0048 0.0076 0.0082
Loa Loa (eye worm) hypothetical protein 0.0046 0.0071 0.0069
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.008 0.0078
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.017 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0004 0.0004
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0039 0.0057 0.0057
Schistosoma mansoni jumonji domain containing protein 0.0074 0.013 0.014
Schistosoma mansoni sodium/chloride dependent transporter 0.0275 0.0547 0.059
Schistosoma mansoni sodium/chloride dependent transporter 0.0275 0.0547 0.059
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0153 0.0295 0.0316
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0038 0.0038
Brugia malayi sulfakinin receptor protein 0.0021 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0056
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0038 0.0661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0053 0.0053
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0083 0.1486
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0022 0.0022
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0275 0.0547 0.0588
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0008 0.0006
Onchocerca volvulus 0.0039 0.0057 0.0041
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0152 0.015
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0026 0.0025
Trichomonas vaginalis dullard protein, putative 0.0012 0.0002 0.0023
Echinococcus granulosus glycine receptor subunit beta 0.0085 0.0152 0.0162
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0038 0.0038
Brugia malayi Cation transporter family protein 0.0159 0.0306 0.0306
Brugia malayi hypothetical protein 0.0021 0.0019 0.0019
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0016 0.0017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0196 0.0383 0.5786
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0024 0.0023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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