Detailed information for compound 1538001

Basic information

Technical information
  • TDR Targets ID: 1538001
  • Name: 6-fluoro-1-methyl-7-morpholin-4-yl-3-phenylsu lfonylquinolin-4-one
  • MW: 402.439 | Formula: C20H19FN2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc2c(cc1N1CCOCC1)n(C)cc(c2=O)S(=O)(=O)c1ccccc1
  • InChi: 1S/C20H19FN2O4S/c1-22-13-19(28(25,26)14-5-3-2-4-6-14)20(24)15-11-16(21)18(12-17(15)22)23-7-9-27-10-8-23/h2-6,11-13H,7-10H2,1H3
  • InChiKey: KQIRKQRTEDLCCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-fluoro-1-methyl-7-morpholino-3-phenylsulfonyl-quinolin-4-one
  • 6-fluoro-1-methyl-7-morpholino-3-phenylsulfonyl-4-quinolinone
  • 6-fluoro-1-methyl-7-morpholino-3-phenylsulfonyl-4-quinolone
  • 6-fluoro-1-methyl-7-morpholin-4-yl-3-phenylsulfonyl-quinolin-4-one
  • E599-0007
  • NCGC00141597-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.034 0.034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0783 0.2127
Schistosoma mansoni single-minded 0.0047 0.0486 0.06
Plasmodium falciparum heat shock protein 90, putative 0.0203 0.2432 1
Echinococcus granulosus glutamate receptor 2 0.0045 0.0453 0.0559
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0365 0.0885
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0423 0.1257
Schistosoma mansoni hypothetical protein 0.0029 0.0264 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0192 0.0521
Mycobacterium ulcerans phytoene synthase, CrtB 0.0156 0.184 0.4998
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0566 0.0918
Echinococcus granulosus hypothetical protein 0.0019 0.0132 0.0163
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1123 0.1366
Brugia malayi diacylglycerol kinase 0.0012 0.0044 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0132 0.0163
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0132 0.0126
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0531 0.0862
Echinococcus granulosus heat shock protein 0.0054 0.0566 0.0699
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.0733
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0332 0.0472
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0132 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.034 0.042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0587 0.0701
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0044 0.013
Brugia malayi Melatonin receptor type 1A 0.0019 0.0132 0.0138
Trypanosoma cruzi phytoene synthase, putative 0.0156 0.184 0.2997
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0453 0.0559
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0119
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0132 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0332 0.0902
Echinococcus granulosus importin subunit beta 1 0.0035 0.0332 0.0409
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4539 0.5594
Echinococcus multilocularis snurportin 1 0.0372 0.4539 0.4539
Onchocerca volvulus 0.0019 0.0132 0.0126
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.2385
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0044 0.0054
Echinococcus granulosus fmrfamide receptor 0.0019 0.0132 0.0163
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0075 0.0839 0.2278
Echinococcus multilocularis heat shock protein 90 0.0054 0.0566 0.0566
Plasmodium falciparum heat shock protein 90 0.0054 0.0566 0.2184
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0015 0.0085 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0587 0.0724
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0132 0.0137
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1384 0.1687
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0132 0.0132
Loa Loa (eye worm) endoplasmin 0.0054 0.0566 0.0674
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0029 0.0264 0.0326
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0085 0.0079
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0132 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0587 0.0587
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0264 0.0326
Leishmania major squalene synthase, putative 0.0499 0.6132 1
Schistosoma mansoni amine GPCR 0.0019 0.0132 0.0163
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0105 0.0105
Schistosoma mansoni sphingoid long chain base kinase 0.0303 0.3681 0.4546
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0057 0.0614 0.688
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0132 0.0137
Onchocerca volvulus 0.0019 0.0132 0.0126
Brugia malayi G-protein coupled receptor 0.0019 0.0132 0.0138
Echinococcus granulosus expressed conserved protein 0.0092 0.1049 0.1295
Brugia malayi Metabotropic glutamate receptor precursor. 0.0015 0.0085 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0117 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Loa Loa (eye worm) serotonin transporter b 0.0338 0.4121 0.5076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Onchocerca volvulus 0.0015 0.0085 0.0068
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0117 0.0318
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0132 0.0163
Schistosoma mansoni amine GPCR 0.0019 0.0132 0.0163
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0029 0.0264 0.0326
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0044 0.0067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0132 0.0137
Schistosoma mansoni hypothetical protein 0.0036 0.0346 0.0428
Brugia malayi CHE-14 protein 0.0042 0.0423 0.0499
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Brugia malayi Pre-SET motif family protein 0.0244 0.2943 0.3619
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0338 0.4121 0.5077
Loa Loa (eye worm) glutamate receptor 0.0015 0.0085 0.0079
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0453 0.0453
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0132 0.0138
Brugia malayi metabotropic glutamate receptor type 2 0.0015 0.0085 0.008
Schistosoma mansoni tyrosine kinase 0.0015 0.0085 0.0105
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0338 0.4121 0.5089
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0075 0.0839 1
Schistosoma mansoni ATP-binding cassette transporter 0.0029 0.0264 0.0326
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0614 0.0758
Onchocerca volvulus 0.0024 0.0192 0.0201
Leishmania major hypothetical protein, conserved 0.0156 0.184 0.2997
Echinococcus granulosus serotonin receptor 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0783 0.0967
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0365 0.1344
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0055 0.0085
Onchocerca volvulus 0.0278 0.3363 0.4131
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0614 0.0758
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0044 0.0067
Schistosoma mansoni neuropeptide receptor 0.0019 0.0132 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1579
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis ceramide kinase 0.0012 0.0044 0.0044
Plasmodium vivax importin-beta 2, putative 0.0035 0.0332 0.1204
Echinococcus granulosus sex peptide receptor 0.0019 0.0132 0.0163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0285
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0105 0.0129
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1123 0.1387
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0365 0.059
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0132 0.0137
Brugia malayi hypoxia-induced factor 1 0.0146 0.1719 0.2104
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0119
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0192 0.0407
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0132 0.0132
Schistosoma mansoni endoplasmin 0.0054 0.0566 0.0699
Echinococcus granulosus glutamate receptor subunit protein glur 0.0029 0.0264 0.0326
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0346 0.0404
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Brugia malayi Muscleblind-like protein 0.0149 0.1758 0.2151
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0579 0.2239
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0057 0.0614 0.0614
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0132 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.0735
Schistosoma mansoni histamine h1 receptor 0.0019 0.0132 0.0163
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0075 0.0839 0.2278
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.0735
Echinococcus multilocularis endoplasmin 0.005 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0211
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0132 0.0163
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0132 0.0163
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0156 0.184 0.2244
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0036 0.0341 0.0421
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0531 0.0656
Trichomonas vaginalis ran, putative 0.0026 0.0217 0.0643
Onchocerca volvulus 0.0019 0.0132 0.0126
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0132 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0132 0.0163
Echinococcus granulosus metabotropic glutamate receptor 2 0.0015 0.0085 0.0105
Schistosoma mansoni ferritin 0.0008 0 0.0001
Echinococcus granulosus neuropeptide receptor 0.0019 0.0132 0.0163
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0044 0.0067
Brugia malayi neuropeptide F receptor 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.0053 0.0555 0.066
Toxoplasma gondii heat shock protein 90, putative 0.0054 0.0566 0.2184
Schistosoma mansoni endoplasmin 0.0054 0.0566 0.0699
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0382 0.1135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0587 0.07
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0192 0.0521
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0249 0.074
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0192 0.0521
Onchocerca volvulus 0.0057 0.0614 0.0723
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1579
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0075 0.0839 0.2035
Leishmania major diacylglycerol kinase, putative 0.0012 0.0044 0.0067
Echinococcus multilocularis protein patched 0.0042 0.0423 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.165 0.165
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0132 0.0132
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0132 0.0132
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0192 0.3655
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0531 0.0632
Brugia malayi MAP kinase sur-1 0.0051 0.0531 0.0633
Brugia malayi Dopamine receptor 0.0019 0.0132 0.0138
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0085 0.0105
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0132 0.0137
Echinococcus multilocularis vesicular acetylcholine transporter 0.0657 0.8098 0.8098
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0029 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0587 0.0724
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Plasmodium vivax SET domain protein, putative 0.0036 0.034 0.124
Echinococcus granulosus heat shock protein 90 0.0054 0.0566 0.0699
Brugia malayi hypothetical protein 0.0057 0.0614 0.0735
Schistosoma mansoni importin beta-1 0.0035 0.0332 0.0409
Loa Loa (eye worm) hypothetical protein 0.0017 0.0105 0.0103
Loa Loa (eye worm) glutamate receptor 2 0.0029 0.0264 0.0301
Onchocerca volvulus 0.0019 0.0132 0.0126
Onchocerca volvulus 0.0057 0.0614 0.0723
Echinococcus granulosus single minded 2 0.0035 0.0332 0.0411
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0566 0.0918
Toxoplasma gondii heat shock protein 75, putative 0.0036 0.0341 0.1244
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0657 0.8098 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0132 0.0132
Onchocerca volvulus 0.0019 0.0132 0.0126
Echinococcus granulosus heat shock protein 90 0.0046 0.0469 0.0579
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0132 0.0132
Onchocerca volvulus 0.0036 0.034 0.0384
Loa Loa (eye worm) hypothetical protein 0.0338 0.4121 0.5076
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.005 0.0147
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.005 0.0525 1
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0332 0.0387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Brugia malayi CXXC zinc finger family protein 0.0028 0.0248 0.0282
Schistosoma mansoni hypothetical protein 0.052 0.6386 0.7886
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0591 0.073
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0469 0.1394
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Leishmania major importin beta-1 subunit, putative 0.0028 0.0249 0.0401
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0249 0.074
Echinococcus multilocularis sex peptide receptor 0.0019 0.0132 0.0132
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0036 0.0341 0.0817
Onchocerca volvulus 0.0338 0.4121 0.507
Loa Loa (eye worm) hypothetical protein 0.0188 0.2242 0.2749
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0132 0.0132
Schistosoma mansoni heat shock protein 0.0036 0.0341 0.0421
Trypanosoma cruzi squalene synthase, putative 0.0499 0.6132 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0132 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0783 0.0967
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1579
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Trypanosoma brucei C-8 sterol isomerase, putative 0.0367 0.4484 0.7294
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0055 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni cpg binding protein 0.003 0.0268 0.0331
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0192 0.0213
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0044 0.0067
Onchocerca volvulus 0.0015 0.0085 0.0068
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0036 0.0341 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0332 0.0332
Echinococcus multilocularis cpg binding protein 0.003 0.0268 0.0268
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.005 0.0147
Schistosoma mansoni amine GPCR 0.0019 0.0132 0.0163
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.005 0.0147
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0085 0.0105
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0132 0.0163
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.0129
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0531 0.0656
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0085 0.0079
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0192 0.0407
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0614 0.0614
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0453 0.0453
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0132 0.0163
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0566 0.0857
Giardia lamblia Grp94/Hsp90 0.005 0.0525 0.8822
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0566 0.0918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0566 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0044 0.0067
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0044 0.0028
Brugia malayi MH2 domain containing protein 0.0119 0.1384 0.1689
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0132 0.0132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0132 0.0163
Trypanosoma brucei heat shock protein 84, putative 0.0036 0.0341 0.0488
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0365 0.0451
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0132 0.0163
Entamoeba histolytica hypothetical protein 0.0028 0.0249 0.0564
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0132 0.0137
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0132 0.0138
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0132 0.0163
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0192 0.0308
Mycobacterium ulcerans heat shock protein 90 0.005 0.0525 0.1424
Schistosoma mansoni ferritin light chain 0.0008 0 0.0001
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0531 0.902
Brugia malayi Serotonin receptor 0.0019 0.0132 0.0138
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0657 0.8098 1
Echinococcus multilocularis tyrosine kinase 0.0015 0.0085 0.0085
Echinococcus multilocularis nmda type glutamate receptor 0.0105 0.1206 0.1206
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0132 0.0132
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.005 0.0525 0.1424
Echinococcus multilocularis NMDA receptor 0.0029 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0469 0.723
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0132 0.0163
Schistosoma mansoni protein kinase 0.0015 0.0085 0.0105
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0132 0.0163
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0566 0.0857
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.005 0.0147
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Plasmodium vivax amine transporter, putative 0.0057 0.0614 0.2385
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0132 0.0163
Loa Loa (eye worm) solute carrier family 6 member 4 0.0338 0.4121 0.5076
Brugia malayi hypothetical protein 0.0158 0.1872 0.2293
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Onchocerca volvulus 0.0019 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0211
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.005 0.0147
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0132 0.0132
Schistosoma mansoni cpg binding protein 0.003 0.0268 0.0331
Echinococcus granulosus geminin 0.052 0.6386 0.7886
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.2385
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0132 0.0132
Echinococcus granulosus g protein coupled receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0132 0.0132
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0591 0.0707
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0015 0.0085 0.0085
Mycobacterium ulcerans hypothetical protein 0.0024 0.0192 0.0521
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0132 0.0132
Schistosoma mansoni sodium/chloride dependent transporter 0.0338 0.4121 0.5089
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.034 0.124
Trypanosoma cruzi extracellular receptor, putative 0.0015 0.0085 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0035
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0132 0.0132
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0217 0.0242
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0044 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0028
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0044 0.0028
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1123 0.2967
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0045 0.0453 0.0453
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0057 0.0614 0.0614
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.005 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0117 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0132 0.0132
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0365 0.0427
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0029 0.0264 0.0264
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0046 0.0469 0.0579
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0132 0.0163
Schistosoma mansoni ap endonuclease 0.0037 0.0365 0.0451
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0614 0.0758
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0192 0.0521
Chlamydia trachomatis glutamine binding protein 0.0075 0.0839 1
Onchocerca volvulus 0.0019 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0044 0.013
Echinococcus granulosus ferritin 0.0008 0 0.0001
Trypanosoma cruzi Heat shock protein 83, putative 0.0054 0.0566 0.0918
Schistosoma mansoni tyrosine kinase 0.0015 0.0085 0.0105
Echinococcus granulosus expressed protein 0.0008 0 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0217 0.0723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0783 0.0783
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0192 0.0308
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0132 0.0163
Loa Loa (eye worm) glutamate receptor 1 0.0029 0.0264 0.0301
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0192 0.0521
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0105 0.0105
Brugia malayi AKH receptor 0.0019 0.0132 0.0138
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Onchocerca volvulus 0.0019 0.0132 0.0126
Trichomonas vaginalis bmru protein, putative 0.0012 0.0044 0.013
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0132 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Brugia malayi neuropeptide F receptor 0.0019 0.0132 0.0138
Schistosoma mansoni apoferritin-2 0.0008 0 0.0001
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Trypanosoma brucei squalene synthase, putative 0.0499 0.6132 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Schistosoma mansoni sodium/chloride dependent transporter 0.0058 0.0619 0.0765
Schistosoma mansoni opsin-like receptor 0.0019 0.0132 0.0163
Toxoplasma gondii hypothetical protein 0.0057 0.0614 0.2385
Echinococcus granulosus Squalene phytoene synthase 0.0156 0.184 0.2272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.0724
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0029 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0338 0.4121 0.5076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0132 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0587 0.0587
Echinococcus multilocularis muscleblind protein 0.0149 0.1758 0.1758
Entamoeba histolytica Ran family GTPase 0.0026 0.0217 0.0475
Schistosoma mansoni adenoreceptor 0.0019 0.0132 0.0163
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0163
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0531 0.0801
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.005 0.0525 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0223 0.0249
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0105 0.0103
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0057 0.0614 0.0735
Loa Loa (eye worm) norepinephrine transporter 0.0338 0.4121 0.5076
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0132 0.0163
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Brugia malayi Serotonin receptor 0.0019 0.0132 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1719 0.2102
Brugia malayi PAS domain containing protein 0.0047 0.0486 0.0576
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0566 0.1681
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0044 0.0067
Plasmodium falciparum transporter, putative 0.0057 0.0614 0.2385
Schistosoma mansoni hypothetical protein 0.052 0.6386 0.7886
Echinococcus granulosus allatostatin A receptor 0.0019 0.0132 0.0163
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0192 0.0407
Brugia malayi Pre-SET motif family protein 0.0036 0.034 0.0396
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0085 0.008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0026
Echinococcus granulosus nmda type glutamate receptor 0.0105 0.1206 0.149
Schistosoma mansoni glutamate receptor NMDA 0.0045 0.0453 0.0559
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0132 0.0137
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0591 0.1605
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0365 0.099
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0192 0.0521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.034 0.042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0591 0.1605
Plasmodium vivax endoplasmin, putative 0.0054 0.0566 0.2184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0614 0.2385
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0249 0.0401
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.2385
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0132 0.0132
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0591 0.073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0217 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0147
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0044 0.013
Onchocerca volvulus 0.0019 0.0132 0.0126
Brugia malayi larval opioid receptor 0.0019 0.0132 0.0138
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Plasmodium falciparum amino acid transporter, putative 0.0057 0.0614 0.2385
Loa Loa (eye worm) hypothetical protein 0.0158 0.1872 0.2292
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0132 0.0163
Schistosoma mansoni sphingosine kinase A B 0.0303 0.3681 0.4546
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.005 0.0076
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.005 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0192 0.0521
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0264 0.0326
Echinococcus granulosus GPCR family 2 0.0017 0.0105 0.0129
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0303 0.3681 0.4532
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0044 0.013
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0217 0.0217
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0029 0.0264 0.0264
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0015 0.0085 0.0068
Brugia malayi Glutamate receptor 1 precursor 0.0029 0.0264 0.0302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0028
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0044 0.013
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0423 0.0423
Brugia malayi heat shock protein 90 0.0054 0.0566 0.0676
Brugia malayi ORL1-like opioid receptor 0.0019 0.0132 0.0138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0365 0.059
Echinococcus granulosus ceramide kinase 0.0012 0.0044 0.0054
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0132 0.0137
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0055 0.0085
Echinococcus multilocularis heat shock protein 0.0054 0.0566 0.0566
Loa Loa (eye worm) heat shock protein 90 0.0054 0.0566 0.0674
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Echinococcus granulosus snurportin 1 0.0372 0.4539 0.5606
Toxoplasma gondii hypothetical protein 0.0057 0.0614 0.2385
Treponema pallidum sodium- and chloride- dependent transporter 0.0338 0.4121 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0365 0.099
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Schistosoma mansoni glutamate receptor AMPA 0.0029 0.0264 0.0326
Leishmania major hypothetical protein, conserved 0.0012 0.0044 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0783 0.2127
Echinococcus granulosus tyrosine kinase 0.0015 0.0085 0.0105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.034 0.034
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0156 0.184 0.4998
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0044 0.0119
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0132 0.0163
Echinococcus granulosus neuropeptide receptor 0.0019 0.0132 0.0163
Schistosoma mansoni amine GPCR 0.0019 0.0132 0.0163
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0132 0.0137
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0192 0.3655
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.005 0.0061
Schistosoma mansoni hypothetical protein 0.0012 0.0044 0.0054
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0566 0.1434
Brugia malayi vesicular acetylcholine transporter unc-17 0.0657 0.8098 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0132 0.0138
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0332 0.0332
Echinococcus granulosus g protein coupled receptor 0.0019 0.0132 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.0724
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.034 0.042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.034 0.042
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.0735
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0365 0.0527
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0316 0.0391
Schistosoma mansoni cpg binding protein 0.0028 0.0248 0.0306
Echinococcus granulosus muscleblind protein 0.0149 0.1758 0.2171
Entamoeba histolytica hypothetical protein, conserved 0.0303 0.3681 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0132 0.0163
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.0129
Echinococcus multilocularis serotonin receptor 0.0019 0.0132 0.0132
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0075 0.0839 0.2035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0248 0.0281
Brugia malayi Hsp90 protein 0.0036 0.0341 0.0398
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0217 0.0243
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0132 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0132 0.0163
Echinococcus granulosus glutamate NMDA receptor subunit 0.0029 0.0264 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0591 0.0591
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0163
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.005 0.0076
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.0129
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0085 0.0085
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0044 0.0067
Loa Loa (eye worm) hypothetical protein 0.0149 0.1758 0.215
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0192 0.0213
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0783 0.2127
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0177 0.0283
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Schistosoma mansoni hypothetical protein 0.0041 0.0404 0.0499
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0614 0.0758
Schistosoma mansoni heat shock protein 0.0054 0.0566 0.0699
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.0724
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1384 0.1687
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0192 0.0521
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0365 0.059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0541 0.0644
Schistosoma mansoni apoferritin-2 0.0008 0 0.0001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.005 0.0147
Leishmania major C-8 sterol isomerase-like protein 0.0367 0.4484 0.7312
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0105 0.0129
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0055 0.0085
Plasmodium vivax heat shock protein 86, putative 0.0054 0.0566 0.2184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Brugia malayi G-protein coupled receptor 0.0019 0.0132 0.0138
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0044 0.013
Schistosoma mansoni ferritin 0.0008 0 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0469 0.076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Toxoplasma gondii Hsp90 domain-containing protein 0.0203 0.2432 1
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0044 0.0054
Schistosoma mansoni neuropeptide receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0149 0.1758 0.215
Echinococcus granulosus vesicular acetylcholine transporter 0.0657 0.8098 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0217 0.0268
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0469 0.076
Trypanosoma brucei protein kinase, putative 0.0051 0.0531 0.0801
Onchocerca volvulus 0.0012 0.005 0.0024
Brugia malayi Dopamine receptor protein 1 0.0019 0.0132 0.0138
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Leishmania major hypothetical protein, conserved 0.0012 0.0044 0.0067
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0365 0.4247
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0085 0.008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0555 0.0662
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0085 0.0085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.2943 0.3618
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0044 0.013
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0036 0.0341 0.0386
Mycobacterium tuberculosis Conserved protein 0.0303 0.3681 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0367 0.4484 0.5527
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0085 0.008
Brugia malayi RE15519p 0.0019 0.0132 0.0138
Brugia malayi Ceramide kinase 0.0012 0.0044 0.003
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0192 0.0213
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0566 0.0918
Echinococcus granulosus serotonin transporter 0.0338 0.4121 0.5089
Schistosoma mansoni biogenic amine receptor 0.0019 0.0132 0.0163
Schistosoma mansoni opsin-like receptor 0.0019 0.0132 0.0163
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0085 0.0105
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0544 0.0647
Plasmodium falciparum endoplasmin, putative 0.0039 0.0382 0.1416
Echinococcus multilocularis glutamate receptor 2 0.0045 0.0453 0.0453
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0045 0.0453 0.0559
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0132 0.0138
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0332 0.0472
Plasmodium vivax heat shock protein 90, putative 0.0036 0.0341 0.1244
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0057 0.0614 0.0758
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis somatostatin receptor 0.0019 0.0132 0.0132
Brugia malayi RNA, U transporter 1 0.0099 0.1133 0.1378
Schistosoma mansoni ferritin light chain 0.0008 0 0.0001
Echinococcus granulosus glutamate receptor 2 0.0015 0.0085 0.0105
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0132 0.0163
Trichomonas vaginalis bmru protein, putative 0.0012 0.0044 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.034 0.042
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0531 0.0862
Onchocerca volvulus 0.0019 0.0132 0.0126
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.005 0.005
Echinococcus granulosus cpg binding protein 0.003 0.0268 0.0331
Loa Loa (eye worm) hypothetical protein 0.0098 0.1123 0.1364
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0217 0.0723
Onchocerca volvulus 0.0019 0.0132 0.0126
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0382 0.1135
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0531 0.0656
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0365 0.1084
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Brugia malayi G protein-coupled receptor 0.0019 0.0132 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0132 0.0132
Echinococcus multilocularis GPCR, family 2 0.0017 0.0105 0.0105
Schistosoma mansoni myosin xvIII 0.0019 0.0132 0.0163
Trichomonas vaginalis heat shock protein, putative 0.005 0.0525 0.1559
Echinococcus granulosus somatostatin receptor 0.0019 0.0132 0.0163
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0365 0.6954
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0132 0.0137
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0423 0.0522
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0423 0.0497
Echinococcus multilocularis Squalene phytoene synthase 0.0156 0.184 0.184
Schistosoma mansoni patched 1 0.0042 0.0423 0.0522
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0132 0.0138
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0453 0.0559
Brugia malayi GnHR receptor homolog 0.0019 0.0132 0.0138
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0015 0.0085 0.0079
Schistosoma mansoni hypothetical protein 0.0156 0.184 0.2272
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.005 0.0147
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0531 0.0531
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0132 0.0163
Schistosoma mansoni hypothetical protein 0.0041 0.0404 0.0499
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Trypanosoma cruzi heat shock protein, putative 0.0036 0.0341 0.0551
Echinococcus granulosus sphingosine kinase 1 0.0303 0.3681 0.4546
Brugia malayi diacylglycerol kinase 0.0012 0.0044 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0365 0.1344
Onchocerca volvulus 0.0019 0.0132 0.0126
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0132 0.0163
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0783 0.0967
Echinococcus multilocularis geminin 0.052 0.6386 0.6386
Echinococcus multilocularis protein dispatched 1 0.0048 0.0497 0.0497
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0286 0.0848
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0783 0.3095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.005 0.0147
Echinococcus multilocularis sphingosine kinase 1 0.0303 0.3681 0.3681
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0423 0.0522
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.005 0.0061
Schistosoma mansoni ran 0.0026 0.0217 0.0268
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0044 0.003
Loa Loa (eye worm) hypothetical protein 0.0367 0.4484 0.5526
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0132 0.0163
Schistosoma mansoni hypothetical protein 0.0041 0.0404 0.0499
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0132 0.0132
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0132 0.0132
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0531 0.0862
Loa Loa (eye worm) hypothetical protein 0.0338 0.4121 0.5076
Loa Loa (eye worm) hypothetical protein 0.0156 0.184 0.2252
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Schistosoma mansoni hypothetical protein 0.0041 0.0404 0.0499
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0057 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0085 0.0105
Onchocerca volvulus 0.0012 0.0044 0.0017
Entamoeba histolytica hypothetical protein 0.0015 0.0085 0.0113
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0555 0.0662
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0132 0.0132
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0132 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0365 0.0425
Echinococcus multilocularis serotonin transporter 0.0338 0.4121 0.4121
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0132 0.0163
Mycobacterium leprae Possible regulatory protein 0.0012 0.005 0.094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Brugia malayi hypothetical protein 0.0012 0.0044 0.003
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0044 0.003
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0044 0.0054
Schistosoma mansoni ap endonuclease 0.0037 0.0365 0.0451
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0614 0.0733
Onchocerca volvulus 0.0019 0.0132 0.0126
Onchocerca volvulus 0.0019 0.0132 0.0126
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Onchocerca volvulus 0.0035 0.0332 0.0375
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0044 0.0054
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0217 0.0348
Schistosoma mansoni hypothetical protein 0.0372 0.4539 0.5606
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.0395
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0132 0.0163
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0105 0.1206 0.1206
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0132 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0085 0.0079
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0117 0.0307
Leishmania major GTP-binding protein, putative 0.0026 0.0217 0.0348
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Loa Loa (eye worm) heat shock protein 75 0.0036 0.0341 0.0396
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0132 0.0163
Echinococcus granulosus g protein coupled receptor 0.0019 0.0132 0.0163
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0132 0.0163
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0132 0.0163
Trichomonas vaginalis heat shock protein, putative 0.005 0.0525 0.1559
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1123 0.1123
Toxoplasma gondii heat shock protein HSP90 0.0054 0.0566 0.2184
Treponema pallidum heat shock protein 90 0.005 0.0525 0.1272
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Onchocerca volvulus 0.0019 0.0132 0.0126
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0044 0.0119
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0044 0.0044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0132 0.0132
Brugia malayi Dopamine receptor protein 2 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0192 0.0521
Trypanosoma brucei Heat shock protein 83, putative 0.0054 0.0566 0.0857
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0249 0.074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0085 0.0079
Schistosoma mansoni opsin-like receptor 0.0019 0.0132 0.0163
Leishmania major protein kinase, putative 0.0013 0.0055 0.0085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0028
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0085 0.0085
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0531 0.0862
Schistosoma mansoni neuropeptide receptor 0.0019 0.0132 0.0163
Brugia malayi sulfakinin receptor protein 0.0019 0.0132 0.0138
Plasmodium falciparum heat shock protein 90, putative 0.0031 0.0286 0.1011
Leishmania major heat shock protein, putative 0.0036 0.0341 0.0551
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0365 0.0365
Brugia malayi Importin beta-1 subunit 0.0035 0.0332 0.0386
Leishmania major heat shock protein 83-1 0.0054 0.0566 0.0918
Schistosoma mansoni neuropeptide receptor 0.0019 0.0132 0.0163
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0044 0.0054
Plasmodium vivax heat shock protein, putative 0.0203 0.2432 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0119
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0015 0.0085 0.0079
Echinococcus granulosus endoplasmin 0.005 0.0525 0.0648
Schistosoma mansoni ferritin 0.0008 0 0.0001
Brugia malayi Glutamate receptor 2 precursor 0.0029 0.0264 0.0302
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0132 0.0163
Schistosoma mansoni biogenic amine receptor 0.0019 0.0132 0.0163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0105 0.0285
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0453 0.0559
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0044 0.0044
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0044 0.0017
Plasmodium falciparum importin beta, putative 0.0035 0.0332 0.1204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0365 0.0882
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0264 0.0326
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Echinococcus granulosus metabotropic glutamate receptor 5 0.0015 0.0085 0.0105
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0217 0.0284
Schistosoma mansoni ran 0.0026 0.0217 0.0268
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.165 0.2037
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0531 0.2041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0531 0.0862
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0264 0.0326
Brugia malayi Endoplasmin precursor 0.0054 0.0566 0.0676
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0132 0.0132
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0591 0.0959
Schistosoma mansoni biogenic amine receptor 0.0019 0.0132 0.0163
Leishmania major protein kinase, putative 0.0013 0.0055 0.0085
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0531 0.0862
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni ferritin 0.0008 0 0.0001
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.005 0.0525 0.0851
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0132 0.0132
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0044 0.0067
Schistosoma mansoni glutamate receptor AMPA 0.0029 0.0264 0.0326
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0132 0.0163
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0614 0.0758
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0365 0.1084
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0132 0.0132
Onchocerca volvulus 0.0028 0.0248 0.027
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0217 0.0723
Onchocerca volvulus 0.0019 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Brugia malayi hypothetical protein 0.0015 0.0085 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0555 0.066
Onchocerca volvulus 0.0057 0.0614 0.0723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0132 0.0163
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0566 0.1434
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0085 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni sodium-dependent amino acid transporter 0.0057 0.0614 0.0758
Loa Loa (eye worm) hypothetical protein 0.0042 0.0423 0.0497
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0029 0.0264 0.0326
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0044 0.0054
Echinococcus multilocularis expressed conserved protein 0.0092 0.1049 0.1049
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0132 0.0163
Toxoplasma gondii exonuclease III APE 0.0037 0.0365 0.1344
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0085 0.0105
Schistosoma mansoni vesicular acetylcholine transporter 0.0657 0.8098 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0192 0.0308
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0044 0.0067
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0132 0.0163
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0132 0.0132
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0614 0.0758
Echinococcus multilocularis heat shock protein 90 0.0046 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0132 0.0163
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0163
Echinococcus granulosus orexin receptor type 2 0.0019 0.0132 0.0163
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.002 0.0146 0.0402
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0486 0.06
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Echinococcus multilocularis serotonin receptor 0.0019 0.0132 0.0132
Mycobacterium ulcerans hypothetical protein 0.0303 0.3681 1
Leishmania major extracellular receptor, putative 0.0015 0.0085 0.0134
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0044 0.0044
Brugia malayi hypothetical protein 0.0019 0.0132 0.0138
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0453 0.0453
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1579
Trichomonas vaginalis set domain proteins, putative 0.0278 0.3363 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0211
Brugia malayi Cytochrome P450 family protein 0.0026 0.0223 0.0251
Brugia malayi putative neuropeptide receptor 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0332 0.0384
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0332 0.1204
Schistosoma mansoni amine GPCR 0.0019 0.0132 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0658 0.0813
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0036 0.0346 0.0402
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0614 0.0758
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0783 0.1273
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0367 0.4484 0.7312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0085 0.0085
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1142 0.1411
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0044 0.013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0591 0.1605
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0085 0.0079
Onchocerca volvulus 0.0019 0.0132 0.0126
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0119
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0733
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0132 0.0132
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0614 0.0758
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0783 0.2127
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1758 0.1758
Schistosoma mansoni heat shock protein 0.0054 0.0566 0.0699
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0132 0.0132
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0044 0.0067
Trypanosoma cruzi squalene synthase, putative 0.0499 0.6132 1
Trypanosoma brucei heat shock protein, putative 0.0054 0.0566 0.0857
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0132 0.0138
Schistosoma mansoni hypothetical protein 0.0017 0.0105 0.0129
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0132 0.0163
Loa Loa (eye worm) ceramide kinase 0.0012 0.0044 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5805 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 0.7079 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 59.7279 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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