Detailed information for compound 1550474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 938.201 | Formula: C54H75N5O9
  • H donors: 5 H acceptors: 6 LogP: 7.22 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOC(=O)[C@@H](NC(=O)[C@@]1(O)[C@H](O)[C@]2(CC)C=CCN3[C@@H]2[C@@]2([C@@]1(C)N(C)c1c2cc(c(c1)OC)[C@]1(C[C@H]2CN(CCc4c1[nH]c1c4cccc1)C[C@](C2)(O)CC)C(=O)OC)CC3)CC(C)C
  • InChi: 1S/C54H75N5O9/c1-10-13-25-68-44(60)40(26-33(4)5)56-47(62)54(65)46(61)51(12-3)20-16-22-59-24-21-53(45(51)59)37-27-38(42(66-8)28-41(37)57(7)49(53,54)6)52(48(63)67-9)30-34-29-50(64,11-2)32-58(31-34)23-19-36-35-17-14-15-18-39(35)55-43(36)52/h14-18,20,27-28,33-34,40,45-46,55,61,64-65H,10-13,19,21-26,29-32H2,1-9H3,(H,56,62)/t34-,40-,45-,46+,49+,50-,51+,52-,53+,54-/m0/s1
  • InChiKey: UATCLLGRGWLAOY-VWZNINQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0019 0.0005 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0049 0.0149
Echinococcus granulosus heat shock protein 90 0.0051 0.0086 0.0272
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0004 0.0011
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0045 0.3291
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0058 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0015 0.0149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0058 0.0178
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0125 0.0272 0.2425
Schistosoma mansoni hypothetical protein 0.1213 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0192 0.1711
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0184 0.0418 0.0414
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0049 0.0435
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0137 0.0228
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0049 0.0045
Brugia malayi nuclear receptor RXR 0.0021 0.001 0.008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0049 0.0724
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0041 0.0133
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0022 0.0285
Brugia malayi nuclear hormone receptor 0.004 0.0058 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni survival motor neuron protein 0.0094 0.0194 0.0642
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0049 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0058 0.0514
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0086 0.4343
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0058 0.0189
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0049 0.0724
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0005 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0058 0.0506
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0086 0.4343
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0137 0.0228
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0031 0.0027
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0137 0.0228
Trichomonas vaginalis helicase, putative 0.0026 0.0022 0.0285
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0005 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0062 0.0544
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0024
Echinococcus granulosus Protein patched homolog 1 0.0125 0.0272 0.089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni thyroid hormone receptor 0.004 0.0058 0.0189
Brugia malayi nuclear receptor NHR-67 0.0019 0.0004 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0058 0.0506
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0005 0.038
Schistosoma mansoni endoplasmin 0.0065 0.0119 0.0393
Loa Loa (eye worm) hypothetical protein 0.021 0.0484 0.4321
Brugia malayi conserved hypotetical protein 0.0019 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0153 0.0343 0.3058
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0015 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0137 0.0204
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0236 0.0549 0.1823
Onchocerca volvulus Huntingtin homolog 0.012 0.0258 0.4424
Brugia malayi CHE-14 protein 0.0125 0.0272 0.2418
Schistosoma mansoni nuclear hormone receptor 0.004 0.0058 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0086 0.0142
Onchocerca volvulus 0.0115 0.0246 0.4215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.025 0.2233
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0199 0.0195
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0119 0.6111
Mycobacterium ulcerans lipase LipD 0.0072 0.0137 0.0228
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0045 0.0073
Onchocerca volvulus 0.0249 0.0582 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0292 0.0691 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0058 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Echinococcus multilocularis Niemann Pick C1 protein 0.0417 0.1006 0.1003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0119 0.6111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis transcription factor btf3 0.0035 0.0045 0.0041
Echinococcus granulosus cpg binding protein 0.0127 0.0276 0.0907
Brugia malayi steroid hormone receptor 0.004 0.0058 0.0506
Brugia malayi ecdysone receptor 0.0019 0.0004 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Schistosoma mansoni hypothetical protein 0.0841 0.2071 0.6885
Loa Loa (eye worm) DR-78 0.0019 0.0004 0.0037
Brugia malayi hypothetical protein 0.0019 0.0004 0.0028
Trypanosoma brucei ISWI complex protein 0.0045 0.0071 0.3529
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Onchocerca volvulus 0.0072 0.0137 0.2346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0199 0.1771
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0058 0.0506
Echinococcus granulosus histone lysine methyltransferase setb 0.0084 0.0168 0.0545
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Loa Loa (eye worm) bromodomain containing protein 0.0052 0.0088 0.0787
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0034 0.1585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0137 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0058 0.0506
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0045 0.2171
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Plasmodium falciparum heat shock protein 90 0.0065 0.0119 1
Echinococcus granulosus tumor protein p63 0.0341 0.0814 0.2696
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0073 0.0141 0.0137
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0023 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0058 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0074 0.1137
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0082 0.027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0015 0.0024
Onchocerca volvulus 0.0094 0.0194 0.3321
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0137 0.2165
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.112 0.3715
Brugia malayi nuclear receptor RXR 0.0019 0.0004 0.0028
Schistosoma mansoni patched 1 0.0125 0.0272 0.0901
Schistosoma mansoni alpha glucosidase 0.0037 0.0049 0.016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0058 0.0053
Echinococcus multilocularis endoplasmin 0.0051 0.0086 0.0082
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0119 0.1867
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0086 0.0142
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0034 0.003
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0086 0.1326
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0045 0.2171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0058 0.0053
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0137 0.0133
Plasmodium vivax patched family protein, putative 0.0018 0.0001 0.0069
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0192 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0023 0.0379
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Trichomonas vaginalis heat shock protein, putative 0.004 0.0056 0.0841
Brugia malayi nuclear hormone receptor 0.0019 0.0004 0.0028
Brugia malayi DnaJ domain containing protein 0.0062 0.0113 0.1002
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2412 0.6025 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi Endoplasmin precursor 0.0065 0.0119 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0228
Brugia malayi Pre-SET motif family protein 0.0034 0.0041 0.0355
Brugia malayi beta-lactamase family protein 0.0072 0.0137 0.1217
Mycobacterium leprae Probable lipase LipE 0.0072 0.0137 0.0204
Schistosoma mansoni alpha-glucosidase 0.0143 0.0315 0.1046
Onchocerca volvulus 0.0019 0.0004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0113 0.0109
Loa Loa (eye worm) hypothetical protein 0.0121 0.026 0.2324
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0058 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Loa Loa (eye worm) hypothetical protein 0.012 0.0258 0.2302
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.01
Mycobacterium ulcerans beta-lactamase 0.0072 0.0137 0.0228
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0113 0.101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0034 0.1585
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0058 0.0053
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Echinococcus granulosus muscleblind protein 0.0155 0.0347 0.114
Loa Loa (eye worm) hypothetical protein 0.0084 0.0168 0.1499
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Echinococcus granulosus fetal alzheimer antigen falz 0.0073 0.0141 0.0456
Echinococcus multilocularis GPCR, family 2 0.0096 0.0199 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0119 0.6111
Brugia malayi beta-lactamase 0.0072 0.0137 0.1217
Schistosoma mansoni alpha-glucosidase 0.0143 0.0315 0.1046
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0236 0.0549 0.1814
Schistosoma mansoni myst-related protein 0.0019 0.0005 0.0013
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0045 0.0592
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.0525 0.087
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0184 0.0418 0.1379
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0032 0.0091
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0119 0.6111
Toxoplasma gondii exonuclease III APE 0.0019 0.0005 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0058 0.0514
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2412 0.6025 1
Onchocerca volvulus 0.0019 0.0004 0.0055
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.0647
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0058 0.0189
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0034 0.0055
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0023 0.1675
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0137 0.0443
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0119 0.6111
Schistosoma mansoni heat shock protein 0.0026 0.0023 0.0074
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.039 0.6699
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0023 0.1932
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0296 0.0702 0.2333
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Brugia malayi hypothetical protein 0.0019 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0208 0.0481 0.4293
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0199 0.0649
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0192 0.0624
Schistosoma mansoni hypothetical protein 0.0208 0.0481 0.1596
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0004 0.0055
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0049 0.0724
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0119 0.0196
Brugia malayi hypothetical protein 0.0071 0.0136 0.1209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0058 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Schistosoma mansoni bromodomain containing protein 0.0194 0.0445 0.1477
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0096 0.0199 0.1778
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0199 0.1778
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0034 0.0305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0058 0.0506
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0137 0.1224
Trypanosoma brucei polo-like protein kinase 0.0093 0.0192 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0058 0.0514
Echinococcus multilocularis tumor protein p63 0.0341 0.0814 0.081
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0133 0.0291 0.2598
Schistosoma mansoni cpg binding protein 0.0127 0.0276 0.0917
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0119 0.6111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Giardia lamblia Kinase, PLK 0.0093 0.0192 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0663
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0137 0.2165
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0136 0.0451
Brugia malayi hypothetical protein 0.0021 0.001 0.008
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0113 0.1773
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0373 0.0369
Loa Loa (eye worm) hypothetical protein 0.005 0.0082 0.0731
Echinococcus multilocularis protein patched 0.0125 0.0272 0.0268
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0015 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0137 0.0228
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.025 0.2233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0015 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0373 0.3326
Onchocerca volvulus 0.0034 0.0041 0.0685
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus granulosus geminin 0.0841 0.2071 0.6881
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0137 0.709
Plasmodium vivax endoplasmin, putative 0.0065 0.0119 0.8666
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0074 0.1137
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0137 0.2165
Echinococcus granulosus FTZ F1 alpha 0.004 0.0058 0.0178
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0004 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0023 0.0986
Echinococcus granulosus expressed conserved protein 0.0274 0.0646 0.2138
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0137 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0137 0.0228
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.001 0.0019
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0031 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0023 0.0301
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0192 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0034 0.0111
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0004 0.0037
Brugia malayi PHD-finger family protein 0.008 0.0159 0.141
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.0691 0.2286
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0137 0.709
Schistosoma mansoni transcription factor btf3 0.0035 0.0045 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Entamoeba histolytica hypothetical protein 0.0019 0.0005 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0031 0.009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0058 0.0189
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0107 0.0225 0.0734
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0041 0.0037
Schistosoma mansoni coup transcription factor 0.004 0.0058 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0272 0.436
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0058 0.0975
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0004 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0005 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0058 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Echinococcus granulosus endoplasmin 0.0051 0.0086 0.0272
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Schistosoma mansoni kinase 0.0048 0.0077 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0663
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0084 0.0276
Loa Loa (eye worm) beta-lactamase 0.0072 0.0137 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0305 0.0724 0.646
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0347 0.0343
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0136 0.044
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Schistosoma mansoni zinc finger protein 0.0019 0.0004 0.0011
Schistosoma mansoni zinc finger protein 0.0065 0.0119 0.0393
Echinococcus granulosus GPCR family 2 0.0096 0.0199 0.0649
Echinococcus granulosus sterol regulatory element binding protein 0.0125 0.0272 0.089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0058 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0058 0.0506
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0192 0.2726
Loa Loa (eye worm) hypothetical protein 0.0155 0.0347 0.3095
Loa Loa (eye worm) hypothetical protein 0.0292 0.0691 0.6168
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0582 0.942
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0137 0.2165
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0192 0.1704
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0305 0.0724 0.6457
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0058 0.0178
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0192 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0015 0.0149
Echinococcus granulosus Niemann Pick C1 protein 0.0417 0.1006 0.3336
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0192 0.0635
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0058 0.0189
Echinococcus multilocularis zinc finger protein 0.0065 0.0119 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.0168 0.0556
Schistosoma mansoni cpg binding protein 0.0115 0.0246 0.0814
Schistosoma mansoni hypothetical protein 0.0045 0.0071 0.0232
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0058 0.0506
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0058 0.0178
Loa Loa (eye worm) hypothetical protein 0.0155 0.0347 0.3095
Schistosoma mansoni hypothetical protein 0.0062 0.0113 0.0374
Treponema pallidum heat shock protein 90 0.0051 0.0086 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0058 0.0178
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0086 0.4343
Schistosoma mansoni endoplasmin 0.0065 0.0119 0.0393
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0034 0.2491
Schistosoma mansoni heat shock protein 0.0065 0.0119 0.0393
Brugia malayi hypothetical protein 0.012 0.0258 0.2295
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0373 0.1229
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0023 0.1932
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Schistosoma mansoni myst-related protein 0.0019 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0114 0.0243 0.2166
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0058 0.0514
Toxoplasma gondii pantoate-beta-alanine ligase 0.2412 0.6025 1
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0004 0.0028
Brugia malayi Muscleblind-like protein 0.0155 0.0347 0.3089
Brugia malayi latrophilin 2 splice variant baaae 0.0208 0.0481 0.4288
Echinococcus multilocularis protein dispatched 1 0.0143 0.0316 0.0312
Onchocerca volvulus 0.0072 0.0137 0.2346
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.011 0.0985
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0058 0.0189
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0084 0.008
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0119 0.6111
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0119 0.1666
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0031 0.009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0073 0.0141 0.0467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0199 0.0649
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Trypanosoma cruzi ISWI complex protein 0.0045 0.0071 0.3529
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.0123
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0373 0.0369
Echinococcus granulosus zinc finger protein 0.0065 0.0119 0.0382
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0049 0.2372
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.001 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0015 0.0547
Onchocerca volvulus 0.0096 0.0198 0.3385
Loa Loa (eye worm) endoplasmin 0.0065 0.0119 0.1061
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.0617 0.5505
Onchocerca volvulus 0.0072 0.0137 0.2346
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Schistosoma mansoni ap endonuclease 0.0019 0.0005 0.0012
Echinococcus multilocularis heat shock protein 90 0.0065 0.0119 0.0115
Brugia malayi Bromodomain containing protein 0.0114 0.0242 0.2155
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0272 0.2425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0058 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0058 0.0506
Mycobacterium tuberculosis Conserved protein 0.0072 0.0137 0.0228
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0034 0.0297
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.0647
Schistosoma mansoni cpg binding protein 0.0127 0.0276 0.0917
Onchocerca volvulus Huntingtin homolog 0.012 0.0258 0.4424
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0058 0.0053
Brugia malayi hypothetical protein 0.0463 0.112 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.0086 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0049 0.0724
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.0691 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0132
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0072 0.0137 0.1224
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0004 0.0028
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0119 0.6111
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0058 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0058 0.0506
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0136 0.0132
Onchocerca volvulus 0.005 0.0082 0.1395
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0058 0.0178
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Brugia malayi heat shock protein 90 0.0065 0.0119 0.1054
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0034 0.0055
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0034 0.1585
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0034 0.1585
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.112 0.1117
Onchocerca volvulus 0.0023 0.0015 0.0238
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis muscleblind protein 0.0155 0.0347 0.0343
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0031 0.0101
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Schistosoma mansoni zinc finger protein 0.0045 0.0071 0.0232
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.0724
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.0617 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.001 0.008
Brugia malayi Bromodomain containing protein 0.0229 0.0533 0.4749
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0058 0.0189
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0004 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0034 0.003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0194 0.1723
Brugia malayi Pre-SET motif family protein 0.0219 0.0507 0.4517
Schistosoma mansoni hypothetical protein 0.0121 0.026 0.0863
Loa Loa (eye worm) hypothetical protein 0.0463 0.112 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.039 0.6291
Plasmodium falciparum zinc finger protein, putative 0.0019 0.0005 0.0402
Schistosoma mansoni hypothetical protein 0.0094 0.0194 0.0642
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0058 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0058 0.0506
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0004 0.0028
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0049 0.0436
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0507 0.4521
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0119 0.0196
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Leishmania major basic transcription factor 3a, putative 0.0035 0.0045 0.2171
Brugia malayi isocitrate dehydrogenase 0.0031 0.0034 0.0297
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0084 0.0276
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0023 0.0205
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0052 0.2554
Echinococcus multilocularis geminin 0.0841 0.2071 0.2068
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0034 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0137 0.0454
Schistosoma mansoni hypothetical protein 0.0061 0.011 0.0364
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.001 0.003
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0049 0.2372
Brugia malayi nuclear receptor NHR-88 0.004 0.0058 0.0506
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0058 0.0506
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Giardia lamblia Grp94/Hsp90 0.0051 0.0086 0.4343
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Schistosoma mansoni hypothetical protein 0.0071 0.0136 0.0451
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0058 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0137 0.2165
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Trypanosoma cruzi ISWI complex protein 0.0045 0.0071 0.3529
Brugia malayi Hsp90 protein 0.0026 0.0023 0.0197
Loa Loa (eye worm) patched family protein 0.0018 0.0001 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0005 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0663
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0137 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.001 0.008
Echinococcus granulosus transcription factor btf3 0.0035 0.0045 0.0137
Echinococcus granulosus dnaJ subfamily B 0.1213 0.3008 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0413 0.6672
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0015 0.0149
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0113 0.0363
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0199 0.1771
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0058 0.0506
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0192 1
Leishmania major heat shock protein, putative 0.0026 0.0023 0.0986
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0305 0.0724 0.646
Schistosoma mansoni hypothetical protein 0.0096 0.0199 0.066
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0199 0.0195
Plasmodium vivax SET domain protein, putative 0.0034 0.0041 0.2968
Echinococcus multilocularis dnaJ subfamily B 0.1213 0.3008 0.3006
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0049 0.2372
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0004 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0049 0.0045
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Toxoplasma gondii Hsp90 domain-containing protein 0.0026 0.0023 0.0037
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0192 0.3284
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0058 0.0506
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0137 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0086 0.1326
Brugia malayi nuclear receptor NHR-88 0.0019 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0088
Echinococcus granulosus heat shock protein 0.0065 0.0119 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0192 0.3054
Brugia malayi beta-lactamase family protein 0.0072 0.0137 0.1217
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0041 0.0066
Schistosoma mansoni nuclear receptor 0.0019 0.0004 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0022 0.0285
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0058 0.0053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.0168 0.0556
Schistosoma mansoni bromodomain containing protein 0.0019 0.0005 0.0013
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0119 0.6111
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0049 0.0149
Mycobacterium ulcerans hypothetical protein 0.0023 0.0015 0.0024
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0107 0.0225 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis heat shock protein 90 0.0051 0.0086 0.0082
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0058 0.0189
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.0592
Mycobacterium ulcerans hypothetical protein 0.0072 0.0137 0.0228
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0086 0.1326
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2412 0.6025 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0024
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0119 0.1061
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.0617 0.5509
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0022 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.0123
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.1111 0.1845
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0045 0.3798
Plasmodium falciparum endoplasmin, putative 0.004 0.0056 0.4716
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0015 0.0547
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0045 0.2171
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0084 0.0265
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0119 0.8666
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0058 0.0975
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0137 0.0228
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0137 0.0228
Brugia malayi Calcitonin receptor-like protein seb-1 0.0305 0.0724 0.6457
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0004 0.0028
Brugia malayi hypothetical protein 0.0021 0.001 0.008
Brugia malayi CXXC zinc finger family protein 0.0115 0.0246 0.2187
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0058 0.0975
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.001 0.0088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0034 0.2875
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0137 0.709
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0023 0.0986
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0023 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis sterol regulatory element binding protein 0.0125 0.0272 0.0268
Schistosoma mansoni thyroid hormone receptor 0.004 0.0058 0.0189
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0058 0.0514
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0034 0.003
Toxoplasma gondii ABC1 family protein 0.0072 0.0137 0.0226
Leishmania major hypothetical protein, conserved 0.0072 0.0137 0.709
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0004 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0058 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0024
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0119 0.1666
Onchocerca volvulus 0.004 0.0058 0.0975
Trichomonas vaginalis endoplasmin, putative 0.004 0.0056 0.0841
Brugia malayi MH2 domain containing protein 0.0117 0.025 0.2226
Brugia malayi beta-NAC-like protein 0.0035 0.0045 0.0395
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0246 0.2193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Trypanosoma brucei heat shock protein, putative 0.0065 0.0119 0.6111
Brugia malayi ecdysteroid receptor 0.004 0.0058 0.0506
Schistosoma mansoni hypothetical protein 0.0841 0.2071 0.6885
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.0123
Echinococcus multilocularis expressed conserved protein 0.0274 0.0646 0.0643
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0137 0.1217
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0086 0.4343
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0015 0.0547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0058 0.0514
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0022 0.0285
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0005 0.004
Schistosoma mansoni heat shock protein 0.0065 0.0119 0.0393
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Leishmania major heat shock protein 83-1 0.0065 0.0119 0.6111
Plasmodium vivax heat shock protein, putative 0.0026 0.0023 0.1675
Echinococcus multilocularis heat shock protein 0.0065 0.0119 0.0115
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0086 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0058 0.0506
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0001 0.0079
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0034 0.1585
Echinococcus granulosus heat shock protein 90 0.0065 0.0119 0.0382
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.0514
Trypanosoma brucei glucosidase, putative 0.0037 0.0049 0.2372
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0373 0.3332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0084 0.0168 0.0164
Toxoplasma gondii heat shock protein 75, putative 0.0026 0.0023 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0037
Brugia malayi tailless protein 0.0019 0.0004 0.0028
Leishmania major hypothetical protein, conserved 0.0045 0.0071 0.3529
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0004 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0413 0.6672
Echinococcus multilocularis cpg binding protein 0.0127 0.0276 0.0272
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0236 0.0549 0.0545
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0086 0.0272
Trichomonas vaginalis esterase, putative 0.0072 0.0137 0.2165
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0245 0.0573 0.1903
Entamoeba histolytica hypothetical protein 0.0071 0.0136 0.1919
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0045 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0058 0.0514
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0041 0.0133
Brugia malayi Niemann-Pick C1 protein precursor 0.0292 0.0691 0.6165
Schistosoma mansoni nuclear receptor 0.0019 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.012 0.0258 0.2302

Activities

Activity type Activity value Assay description Source Reference
ILS (functional) = 13.8 % Percent increase in life span at dose 65 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 23 % Percent increase in life span at dose 55 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 26 % Percent increase in life span at dose 60 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 26.7 % Percent increase in life span at dose 70 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 27.6 % Percent increase in life span at dose 80 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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