Detailed information for compound 1554782

Basic information

Technical information
  • TDR Targets ID: 1554782
  • Name: 5-chloro-N-[(4-methoxyphenyl)methyl]-2-[(4-me thylphenyl)methylsulfanyl]pyrimidine-4-carbox amide
  • MW: 413.92 | Formula: C21H20ClN3O2S
  • H donors: 1 H acceptors: 3 LogP: 4.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)c1nc(ncc1Cl)SCc1ccc(cc1)C
  • InChi: 1S/C21H20ClN3O2S/c1-14-3-5-16(6-4-14)13-28-21-24-12-18(22)19(25-21)20(26)23-11-15-7-9-17(27-2)10-8-15/h3-10,12H,11,13H2,1-2H3,(H,23,26)
  • InChiKey: BGTRZDMMTIBBPK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-[(4-methoxyphenyl)methyl]-2-[(4-methylphenyl)methylthio]-4-pyrimidinecarboxamide
  • 5-chloro-N-(4-methoxybenzyl)-2-[(4-methylbenzyl)thio]pyrimidine-4-carboxamide
  • D233-0104
  • NCGC00117391-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0107 0.0757
Brugia malayi hypothetical protein 0.0047 0.0193 0.1391
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0004 0.0004
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0025 0.0282
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0114 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0461
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0025 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0107 0.0107
Brugia malayi nuclear receptor RXR 0.0017 0.0015 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.009 0.0127
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.034 0.1719
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0114 0.0812
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0021 0.003
Brugia malayi CXXC zinc finger family protein 0.012 0.0621 0.4559
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0303 0.1527
Plasmodium falciparum diacylglycerol kinase, putative 0.0047 0.0193 1
Onchocerca volvulus Huntingtin homolog 0.0139 0.0733 1
Onchocerca volvulus 0.0019 0.0025 0.0282
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0248 0.1244
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0009 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Schistosoma mansoni hypothetical protein 0.0047 0.0193 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Brugia malayi Ceramide kinase 0.0047 0.0193 0.1391
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0107 0.0757
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0259 0.13
Brugia malayi mbt repeat family protein 0.0049 0.0205 0.1481
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Onchocerca volvulus 0.0019 0.0025 0.0282
Toxoplasma gondii histone lysine methyltransferase SET1 0.0227 0.1255 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0733 0.1032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0022
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0107 0.0757
Schistosoma mansoni apoferritin-2 0.0026 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0132
Onchocerca volvulus 0.0031 0.0093 0.1221
Plasmodium vivax vivapain-2 0.0019 0.0025 0.0873
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0047 0.0193 0.9833
Leishmania major diacylglycerol kinase, putative 0.0047 0.0193 0.0955
Schistosoma mansoni apoferritin-2 0.0026 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Loa Loa (eye worm) DR-78 0.0016 0.0004 0.0006
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0112 0.0572 0.0806
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.1454 0.8493 0.8493
Brugia malayi Cathepsin L-like precursor 0.0019 0.0025 0.0152
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0056 0.0053
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0025 0.0873
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0042 0.0278
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0247
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0004 0.0006
Echinococcus multilocularis ferritin 0.0026 0.0068 0.0068
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0004 0.0004
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0205 0.0205
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0056 0.005
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0107 0.0757
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0068 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0764 0.1076
Brugia malayi Cytochrome P450 family protein 0.0018 0.0019 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0519 0.3805
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0107 0.0103
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0107 0.0757
Brugia malayi diacylglycerol kinase 0.0047 0.0193 0.1391
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0313 0.0309
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0036
Brugia malayi ecdysteroid receptor 0.0033 0.0107 0.0757
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0033 0.0105 0.01
Echinococcus granulosus expressed protein 0.0026 0.0068 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0384
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Plasmodium vivax diacylglycerol kinase, putative 0.0047 0.0193 1
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0129 0.0923
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0042 0.0207
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0107 0.0757
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0197 0.101
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0025 0.0025
Echinococcus multilocularis expressed conserved protein 0.0105 0.0532 0.0532
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0193 0.0243
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0107 0.0107
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0009 0.0004
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0047 0.0193 0.0272
Schistosoma mansoni hypothetical protein 0.1709 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Leishmania major cytochrome p450-like protein 0.0018 0.0019 0.0052
Schistosoma mansoni ferritin light chain 0.0026 0.0068 0.0064
Brugia malayi hypothetical protein 0.0018 0.0022 0.0128
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0047 0.0193 0.0955
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.034 0.1719
Trypanosoma cruzi diacylglycerol kinase, putative 0.0047 0.0193 0.0955
Leishmania major DNA polymerase kappa, putative 0.0022 0.0042 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0519 0.3805
Trypanosoma cruzi Sphingosine kinase 0.0047 0.0193 0.0955
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0107 0.0757
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0313 0.0313
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0019 0.0088
Plasmodium falciparum diacylglycerol kinase, putative 0.0047 0.0193 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0042 0.1207
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0273 0.0268
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0025 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0015 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Schistosoma mansoni patched 1 0.0048 0.0196 0.0191
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Schistosoma mansoni intermediate filament proteins 0.0031 0.0093 0.0089
Trypanosoma cruzi diacylglycerol kinase, putative 0.0047 0.0193 0.0955
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0068 0.0076
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0056 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0247
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0013
Schistosoma mansoni hypothetical protein 0.0366 0.2072 0.2069
Entamoeba histolytica hypothetical protein 0.0037 0.0131 0.0155
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0025 0.0282
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0019 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0107 0.0151
Echinococcus multilocularis sphingosine kinase 1 0.1217 0.7095 0.7095
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0015 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0107 0.0107
Toxoplasma gondii hypothetical protein 0.0055 0.0239 0.1845
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0093 0.0132
Trichomonas vaginalis sphingosine kinase, putative 0.0047 0.0193 0.9833
Schistosoma mansoni hypothetical protein 0.005 0.0208 0.0203
Trichomonas vaginalis bmru protein, putative 0.0047 0.0193 0.9833
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0384
Schistosoma mansoni lamin 0.0031 0.0093 0.0089
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0047 0.0193 0.9833
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.1933 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0132 0.0132
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0021 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0082 0.0378
Echinococcus granulosus Diacylglycerol kinase theta 0.0047 0.0193 0.0193
Onchocerca volvulus 0.0019 0.0025 0.0282
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0021 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Schistosoma mansoni hypothetical protein 0.0033 0.0105 0.01
Schistosoma mansoni sphingoid long chain base kinase 0.1217 0.7095 0.7093
Entamoeba histolytica cysteine protease, putative 0.0019 0.0025 0.0006
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0205 0.02
Trichomonas vaginalis bmru protein, putative 0.0047 0.0193 0.9833
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0107 0.0757
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.002 0.5
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0033
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1357 0.1357
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0021 0.0021
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0025 0.0873
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0519 0.0732
Brugia malayi Cathepsin L-like precursor 0.0019 0.0025 0.0152
Onchocerca volvulus 0.012 0.0621 0.8471
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0015 0.0022
Schistosoma mansoni cpg binding protein 0.012 0.0621 0.0617
Schistosoma mansoni survival motor neuron protein 0.005 0.0208 0.0203
Brugia malayi CHE-14 protein 0.0048 0.0196 0.1413
Loa Loa (eye worm) cysteine protease 0.0019 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0107 0.0107
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0205 0.0289
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0042 0.0033
Echinococcus multilocularis expressed protein 0.0026 0.0068 0.0068
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0004 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0205 0.02
Echinococcus granulosus intermediate filament protein 0.0031 0.0093 0.0093
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.0582 0.0578
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0025 0.0006
Loa Loa (eye worm) ceramide kinase 0.0047 0.0193 0.0272
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0047 0.0193 0.0955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0107 0.1408
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0025 0.0006
Leishmania major mitochondrial DNA polymerase beta 0.0342 0.1933 1
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0033
Brugia malayi intermediate filament protein 0.0031 0.0093 0.0657
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0196 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Leishmania major cathepsin L-like protease 0.0072 0.034 0.1719
Schistosoma mansoni hypothetical protein 0.0037 0.0131 0.0126
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0196 0.0196
Toxoplasma gondii cathepsin CPL 0.0019 0.0025 0.0129
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0047 0.0193 0.0955
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0107 0.0107
Trichomonas vaginalis diacylglycerol kinase, putative 0.0047 0.0193 0.9833
Loa Loa (eye worm) hypothetical protein 0.0049 0.0205 0.0289
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0196 0.0196
Echinococcus multilocularis lamin 0.0031 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.034 0.1719
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0193 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Loa Loa (eye worm) hypothetical protein 0.0139 0.0733 0.1032
Mycobacterium ulcerans diacylglycerol kinase 0.0047 0.0193 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0107 0.1408
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0015 0.0015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0056 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0107 0.1408
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0114 0.5733
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0127 0.0662 0.0662
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.002 0.0613
Echinococcus granulosus GPCR family 2 0.0033 0.0105 0.0105
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0114 0.0846
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.0572 0.4192
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0009 0.0004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0042 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0056 0.0384
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.002 0.0008
Echinococcus granulosus lamin 0.0031 0.0093 0.0093
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1709 0.9996 0.9996
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0025 0.0025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0042 0.0039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0105 0.0105
Leishmania major cathepsin L-like protease 0.0019 0.0025 0.0083
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.0572 0.0778
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0869 0.447
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0047 0.0193 0.0188
Trichomonas vaginalis diacylglycerol kinase, putative 0.0047 0.0193 0.9833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Trypanosoma brucei unspecified product 0.0022 0.0042 0.0207
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0025 0.0228
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0105 0.0148
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0082 0.3954
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0327 0.2387
Schistosoma mansoni ferritin 0.0026 0.0068 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0042 0.0172
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0245 0.0245
Trichomonas vaginalis helicase, putative 0.0027 0.0073 0.3003
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0009 0.0009
Brugia malayi isocitrate dehydrogenase 0.0034 0.0114 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0107 0.0757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0021 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0107 0.0103
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0255 0.1415 0.1411
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0193 0.0955
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0028
Echinococcus granulosus dna polymerase kappa 0.0022 0.0042 0.0042
Loa Loa (eye worm) diacylglycerol kinase 2 0.0047 0.0193 0.0272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0053
Toxoplasma gondii exonuclease III APE 0.0018 0.0021 0.0097
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0114 0.0547
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0208 0.1501
Schistosoma mansoni hypothetical protein 0.0046 0.0185 0.0181
Echinococcus multilocularis protein dispatched 1 0.0055 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.034 0.1719
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0196 0.0196
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0107 0.0151
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Schistosoma mansoni DNA polymerase eta 0.0022 0.0042 0.0038
Trypanosoma brucei diacylglycerol kinase, putative 0.0047 0.0193 0.0987
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0869 0.447
Brugia malayi Diacylglycerol kinase protein 2 0.0047 0.0193 0.1391
Mycobacterium ulcerans hypothetical protein 0.018 0.0977 0.1354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0487 0.0487
Brugia malayi diacylglycerol kinase 0.0047 0.0193 0.1391
Loa Loa (eye worm) hypothetical protein 0.0059 0.0259 0.0365
Onchocerca volvulus 0.0019 0.0025 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0487 0.357
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0105 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0107 0.0151
Echinococcus granulosus sphingosine kinase 1 0.1217 0.7095 0.7095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0042 0.0172
Schistosoma mansoni ap endonuclease 0.0018 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0047 0.0193 0.0272
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0114 0.0547
Echinococcus multilocularis ceramide kinase 0.0047 0.0193 0.0193
Echinococcus granulosus dna polymerase eta 0.0022 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0148
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0107 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0487 0.0483
Leishmania major cathepsin L-like protease 0.0019 0.0025 0.0083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.002 0.0002
Brugia malayi hypothetical protein 0.0037 0.0131 0.0933
Trichomonas vaginalis ferritin, putative 0.0026 0.0068 0.2689
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0068 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Brugia malayi Eye-specific diacylglycerol kinase 0.0047 0.0193 0.1391
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0107 0.0107
Leishmania major hypothetical protein, conserved 0.0047 0.0193 0.0955
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.0977 0.136
Brugia malayi hypothetical protein 0.0245 0.1357 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0193 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0015 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0073 0.3003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0042 0.0042
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0047 0.0193 0.0188
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0025 0.0873
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0197 0.0978
Leishmania major cathepsin L-like protease 0.0072 0.034 0.1719
Loa Loa (eye worm) CXXC zinc finger family protein 0.012 0.0621 0.0876
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Echinococcus multilocularis microtubule associated protein 2 0.1454 0.8493 0.8493
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.002 0.0613
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0082 0.3954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0107 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0073 0.3003
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0193 0.0243
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0107 0.0107
Brugia malayi Cathepsin L-like precursor 0.0019 0.0025 0.0152
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0009 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0487 0.0487
Brugia malayi nuclear receptor NHR-88 0.0033 0.0107 0.0757
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0073 0.3003
Onchocerca volvulus 0.0019 0.0025 0.0282
Trichomonas vaginalis sphingosine kinase, putative 0.0047 0.0193 0.9833
Onchocerca volvulus 0.005 0.0208 0.279
Trypanosoma brucei Sphingosine kinase 0.0047 0.0193 0.0987
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0107 0.0757
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0114 0.011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0114 0.0114
Echinococcus granulosus expressed conserved protein 0.0105 0.0532 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Echinococcus granulosus ferritin 0.0026 0.0068 0.0068
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0132 0.0186
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0131 0.0126
Loa Loa (eye worm) MBCTL1 0.0056 0.0245 0.0346
Entamoeba histolytica hypothetical protein 0.0037 0.0131 0.0155
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0764 0.1076
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0047 0.0193 0.1475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Echinococcus granulosus cathepsin l1 0.0019 0.0025 0.0025
Leishmania major cathepsin L-like protease 0.0019 0.0025 0.0083
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0205 0.2752
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0082 0.0378
Echinococcus multilocularis lamin dm0 0.0031 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.007 0.0327 0.0323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0073 0.3003
Echinococcus granulosus Niemann Pick C1 protein 0.016 0.0854 0.0854
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0114 0.0581
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.008
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0042 0.0038
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0047 0.0193 0.9833
Schistosoma mansoni hypothetical protein 0.0366 0.2072 0.2069
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0047 0.0193 0.0193
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0114 0.0161
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0107 0.0151
Echinococcus multilocularis GPCR, family 2 0.0033 0.0105 0.0105
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1357 0.1357
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0313 0.0309
Brugia malayi MH2 domain containing protein 0.0144 0.0764 0.5612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0487 0.0487
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0047 0.0193 0.0987
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0073 0.3003
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0342 0.1933 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0197 0.0978
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0197 0.0978
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0013
Echinococcus granulosus lamin dm0 0.0031 0.0093 0.0093
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0132 0.0132
Echinococcus multilocularis cysteine protease 0.0019 0.0025 0.0025
Echinococcus multilocularis geminin 0.0366 0.2072 0.2072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Schistosoma mansoni ferritin 0.0026 0.0068 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0196 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0042 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0107 0.0757
Plasmodium vivax diacylglycerol kinase, putative 0.0047 0.0193 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0004 0.0004
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0245 0.178
Echinococcus granulosus ceramide kinase 0.0047 0.0193 0.0193
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0025 0.0025
Brugia malayi steroid hormone receptor 0.0033 0.0107 0.0757
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0487 0.0487
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0107 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0107 0.0103
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0107 0.0103
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0082 0.0412
Entamoeba histolytica hypothetical protein 0.0037 0.0131 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Onchocerca volvulus 0.0033 0.0107 0.1408
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0245 0.0245
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0015 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0273 0.0273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0487 0.0483
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0025 0.0025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0114 0.0547
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0205 0.02
Loa Loa (eye worm) hypothetical protein 0.1217 0.7095 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0021 0.0063
Loa Loa (eye worm) hypothetical protein 0.0103 0.0519 0.0732
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0313 0.0441
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0056 0.0247
Loa Loa (eye worm) ctsf protein 0.0019 0.0025 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0015 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0073 0.3003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0107 0.0151
Schistosoma mansoni coup transcription factor 0.0033 0.0107 0.0103
Schistosoma mansoni cpg binding protein 0.0127 0.0662 0.0657
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0004 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0042 0.1207
Giardia lamblia DINP protein human, muc B family 0.0022 0.0042 1
Onchocerca volvulus 0.0049 0.0205 0.2752
Onchocerca volvulus 0.0019 0.0025 0.0282
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0068 0.0069
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0107 0.0103
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0089 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0107 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Schistosoma mansoni ferritin 0.0026 0.0068 0.0064
Toxoplasma gondii diacylglycerol kinase, putative 0.0047 0.0193 0.1475
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0107 0.0107
Entamoeba histolytica hypothetical protein, conserved 0.1217 0.7095 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0042 0.0278
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0093 0.0657
Trypanosoma cruzi Sphingosine kinase 0.0047 0.0193 0.0955
Schistosoma mansoni hypothetical protein 0.0046 0.0185 0.0181
Echinococcus granulosus phd:f box containing protein 0.0016 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0068 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0107 0.0757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0042 0.0059
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0025 0.0025
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.001 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0107 0.0757
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0193 0.0987
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0033
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0245 0.1357 0.1913
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0056 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0025 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0107 0.0107
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0107 0.0107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0021 0.0063
Leishmania major sphingosine kinase A, B, putative 0.0047 0.0193 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0042 0.0042
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0033 0.0105 0.01
Echinococcus multilocularis musashi 0.0031 0.0093 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0082 0.3954
Schistosoma mansoni hypothetical protein 0.0046 0.0185 0.0181
Schistosoma mansoni sphingosine kinase A B 0.1217 0.7095 0.7093
Leishmania major cathepsin L-like protease 0.0019 0.0025 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0042 0.0207
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0042 0.0172
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0042 0.003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0107 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0042 0.0207
Brugia malayi Cathepsin L-like precursor 0.0019 0.0025 0.0152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0487 0.0687
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Brugia malayi jmjC domain containing protein 0.0068 0.0313 0.2282
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0093 0.0132
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0025 0.0282
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0068 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0114 0.5733
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0105 0.0105
Brugia malayi Cytochrome P450 family protein 0.0018 0.0019 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0107 0.0107
Schistosoma mansoni cpg binding protein 0.0127 0.0662 0.0657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.0869 0.449
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0205 0.0205
Echinococcus multilocularis cpg binding protein 0.0127 0.0662 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0009 0.0009
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0193 0.0243
Plasmodium vivax vivapain-2 0.0019 0.0025 0.0873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0107 0.0151
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0068 0.0076
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0114 0.0581
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0107 0.0103
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0021 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0107 0.0103
Mycobacterium tuberculosis Diacylglycerol kinase 0.0047 0.0193 0.0252
Echinococcus multilocularis dnaJ subfamily B 0.1709 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0056 0.0053
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0107 0.0103
Leishmania major hypothetical protein, conserved 0.0029 0.0082 0.0378
Loa Loa (eye worm) hypothetical protein 0.0056 0.0245 0.0346
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0004 0.0006
Echinococcus granulosus geminin 0.0366 0.2072 0.2072
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0025 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0089 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0056 0.006
Brugia malayi Cathepsin L-like precursor 0.0019 0.0025 0.0152
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0019 0.0052
Echinococcus multilocularis Niemann Pick C1 protein 0.016 0.0854 0.0854
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Brugia malayi nuclear hormone receptor 0.0033 0.0107 0.0757
Brugia malayi Cathepsin L-like precursor 0.0019 0.0025 0.0152
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0056 0.006
Onchocerca volvulus Ceramide kinase 1 homolog 0.0047 0.0193 0.2585
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0107 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0107 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0193 0.9833
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.1933 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0193 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0245 0.0241
Schistosoma mansoni ap endonuclease 0.0018 0.0021 0.0017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0021 0.0657
Echinococcus granulosus microtubule associated protein 2 0.1454 0.8493 0.8493
Onchocerca volvulus 0.0024 0.0056 0.0714
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0047 0.0193 0.1475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Brugia malayi mbt repeat family protein 0.0049 0.0205 0.1481
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0107 0.0757
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0572 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0025 0.0228
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0025 0.0152
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0245 0.0245
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0107 0.0107
Schistosoma mansoni ferritin light chain 0.0026 0.0068 0.0064
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0025 0.0083
Schistosoma mansoni hypothetical protein 0.0304 0.1709 0.1705
Loa Loa (eye worm) hypothetical protein 0.0048 0.0196 0.0276
Mycobacterium tuberculosis Conserved protein 0.1217 0.7095 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0042 0.0033
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0205 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0056 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0105 0.0105
Schistosoma mansoni ferritin 0.0026 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0022
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0047 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Echinococcus multilocularis protein patched 0.0048 0.0196 0.0196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0073 0.3003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0107 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0042 0.0207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0059
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0107 0.0103
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0015 0.0081
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0114 0.0846
Loa Loa (eye worm) hypothetical protein 0.0047 0.0193 0.0272
Onchocerca volvulus 0.0047 0.0193 0.2585
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0025 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0114 0.0114
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0021 0.0009
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0042 0.0042
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0004 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0107 0.0107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0131 0.0131
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0107 0.0107
Brugia malayi hypothetical protein 0.0017 0.0015 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0107 0.0757
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0042 0.0038
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0009 0.0009
Mycobacterium ulcerans hypothetical protein 0.0024 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0487 0.0483
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0131 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0082 0.0583
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0019 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0042 0.0172
Brugia malayi hypothetical protein 0.0017 0.0015 0.0081
Echinococcus granulosus Diacylglycerol kinase zeta 0.0047 0.0193 0.0193
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0572 0.0572
Leishmania major cathepsin L-like protease 0.0072 0.034 0.1719
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0105 0.0742
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0033 0.0105 0.01
Echinococcus multilocularis Diacylglycerol kinase theta 0.0047 0.0193 0.0193
Brugia malayi hypothetical protein 0.0139 0.0733 0.5382
Schistosoma mansoni hypothetical protein 0.0046 0.0185 0.0181
Onchocerca volvulus Huntingtin homolog 0.0139 0.0733 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0073 0.3003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0042 0.0172
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0056 0.005
Brugia malayi jmjC domain containing protein 0.0061 0.0273 0.1984
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0021 0.0657
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1085 0.1085
Onchocerca volvulus 0.0019 0.0025 0.0282
Leishmania major cathepsin L-like protease 0.0019 0.0025 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0042 0.0172
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0047 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Schistosoma mansoni lamin 0.0031 0.0093 0.0089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0073 0.3003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.034 0.1749
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0009 0.0004
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0193 0.0188
Echinococcus multilocularis dna polymerase eta 0.0022 0.0042 0.0042
Leishmania major diacylglycerol kinase-like protein 0.0047 0.0193 0.0955
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0082 0.0115
Entamoeba histolytica hypothetical protein 0.0037 0.0131 0.0155
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0035
Onchocerca volvulus 0.0031 0.0093 0.1221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0114 0.0141
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0245 0.0245
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0009 0.0004
Leishmania major DNA polymerase eta, putative 0.0022 0.0042 0.0172
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0273 0.0273
Brugia malayi hypothetical protein 0.0029 0.0082 0.057
Mycobacterium ulcerans hypothetical protein 0.1217 0.7095 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0006
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1085 0.1085
Echinococcus multilocularis cysteine protease 0.0019 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0025 0.0228
Loa Loa (eye worm) fibroinase 0.0019 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0025 0.0228
Leishmania major hypothetical protein, conserved 0.0047 0.0193 0.0955
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0151

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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