Detailed information for compound 1558587

Basic information

Technical information
  • TDR Targets ID: 1558587
  • Name: 2-(2-chlorophenyl)-2-oxoethyl N-(phenylacetyl )glycylglycinate
  • MW: 402.828 | Formula: C20H19ClN2O5
  • H donors: 2 H acceptors: 4 LogP: 2.44 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)Cc1ccccc1)NCC(=O)OCC(=O)c1ccccc1Cl
  • InChi: 1S/C20H19ClN2O5/c21-16-9-5-4-8-15(16)17(24)13-28-20(27)12-23-19(26)11-22-18(25)10-14-6-2-1-3-7-14/h1-9H,10-13H2,(H,22,25)(H,23,26)
  • InChiKey: FYSLJGXXCCRZLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000576369
  • STK326899
  • ZINC02594295
  • SMR000198010

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase eta 0.0222 0.1014 0.1009
Leishmania major DNA polymerase kappa, putative 0.0046 0.015 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0265 0.0438
Trypanosoma cruzi trypanothione reductase, putative 0.0502 0.2389 0.8299
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0601 0.2875 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0174 0.078 0.2667
Trichomonas vaginalis apoptosis inducing factor, putative 0.0046 0.0153 0.0239
Trypanosoma brucei DNA polymerase IV, putative 0.0172 0.0773 0.2643
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0018 0.0013
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0565 0.2699 0.4231
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0174 0.078 0.3214
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0174 0.078 0.2667
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0452 0.0498
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0046 0.0153 0.0012
Trichomonas vaginalis glutamate synthase, putative 0.0046 0.0153 0.0239
Loa Loa (eye worm) acetyltransferase 0.0175 0.0786 0.1988
Loa Loa (eye worm) hypothetical protein 0.0058 0.0209 0.052
Schistosoma mansoni disulfide oxidoreductase 0.0046 0.0153 0.0148
Brugia malayi Bromodomain containing protein 0.0062 0.023 0.0587
Giardia lamblia PHD finger protein 15 0.0058 0.0209 0.0254
Giardia lamblia Kinase, PLK 0.0094 0.0388 0.0577
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Echinococcus granulosus axis inhibition protein axin 0.0019 0.002 0.0014
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0046 0.0153 0.057
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0179 0.068
Plasmodium falciparum glutathione reductase 0.0502 0.2389 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0069 0.0214
Chlamydia trachomatis thioredoxin reductase 0.0046 0.0153 0.1187
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.002 0.0014
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0209 0.0204
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0283 0.0278
Leishmania major hypothetical protein, conserved 0.0046 0.0153 0.0473
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0501 0.0496
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Trypanosoma brucei protein kinase, putative 0.005 0.0174 0.0545
Brugia malayi ImpB/MucB/SamB family protein 0.0147 0.0646 0.1645
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0046 0.0153 0.057
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.051 0.1287
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0153 0.0473
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0162 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Brugia malayi glutamate synthase 0.0046 0.0153 0.039
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.002 0.0051
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0046 0.0153 0.057
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0153 0.0473
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0046 0.0153 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.3854 0.3851
Schistosoma mansoni DNA polymerase IV / kappa 0.0046 0.015 0.0145
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0046 0.0153 0.0148
Entamoeba histolytica deoxycytidyl transferase, putative 0.0147 0.0646 0.1123
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0147 0.0646 0.0641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0501 0.0496
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0018 0.0013
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0174 0.019
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.002 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0277 0.0905
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0174 0.078 0.2667
Schistosoma mansoni glutamate synthase 0.0046 0.0153 0.0148
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.002 0.0014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0129 0.0558 0.189
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0174 0.0545
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0174 0.0545
Schistosoma mansoni glutamate synthase 0.0046 0.0153 0.0148
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0452 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0388 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0209 0.0807
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0018 0.0013
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0046 0.0153 0.0148
Brugia malayi PXA domain containing protein 0.0019 0.002 0.0051
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0179 0.0174
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0153 0.0239
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0046 0.0153 0.0012
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0014
Mycobacterium ulcerans hypothetical protein 0.0046 0.0153 0.0012
Trypanosoma cruzi NADH dehydrogenase, putative 0.0046 0.0153 0.0473
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.002 0.0051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0174 0.078 0.3214
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0501 0.0496
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.015 0.0463
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0174 0.0545
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0153 0.0473
Schistosoma mansoni axis inhibition protein axin 0.0019 0.002 0.0014
Onchocerca volvulus 0.0164 0.0732 0.1524
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0024 0.0018
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0265 0.104
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0046 0.0153 0.0456
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0147 0.0646 0.1634
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.002 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0816 0.393 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0105
Schistosoma mansoni glutamate synthase 0.0046 0.0153 0.0148
Plasmodium vivax ferrodoxin reductase, putative 0.0046 0.0153 0.057
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0156 0.0244
Mycobacterium ulcerans DNA polymerase IV 0.0172 0.0773 0.2444
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0174 0.0657
Echinococcus granulosus axis inhibition protein axin 0.0019 0.002 0.0014
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0209 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0452 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0156 0.0244
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0046 0.0153 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0069 0.0088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0046 0.015 0.0557
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.002 0.0014
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0046 0.0153 0.0148
Brugia malayi Smad1 0.0016 0.0005 0.0014
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0164 0.0732 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0265 0.0438
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0388 0.0987
Mycobacterium tuberculosis Probable reductase 0.1145 0.5543 0.8958
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.002 0.0051
Echinococcus multilocularis musashi 0.0027 0.0057 0.0052
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.002 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0174 0.078 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0452 0.0775
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.002 0.0051
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0153 0.0473
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0452 0.1139
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0037
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0153 0.0678 0.231
Toxoplasma gondii peptidylprolyl isomerase 0.0129 0.0558 0.2277
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.0341 0.1132
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0174 0.0276
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0153 0.0239
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0204 0.0212
Loa Loa (eye worm) hypothetical protein 0.0048 0.0162 0.0399
Echinococcus granulosus thioredoxin glutathione reductase 0.0505 0.2403 0.2399
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0019 0.0005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0024 0.0046
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0204 0.052
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0014
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0189 0.0853 0.0848
Trypanosoma brucei polo-like protein kinase 0.0094 0.0388 0.1295
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0123 0.0369
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0153 0.0678 0.0872
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0269 0.0264
Echinococcus granulosus Solute carrier family 22 5 0.102 0.4933 0.493
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0046 0.0153 0.057
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0284 0.1322 0.4564
Echinococcus multilocularis dna polymerase kappa 0.0172 0.0773 0.0768
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0046 0.0153 0.039
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.002 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.015 0.0463
Loa Loa (eye worm) thioredoxin reductase 0.0502 0.2389 0.6074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0204 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0047 0.0121
Brugia malayi jmjC domain containing protein 0.007 0.0269 0.0684
Echinococcus granulosus L aminoadipate semialdehyde 0.0164 0.0732 0.0726
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0502 0.2389 0.3716
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0046 0.0153 0.0473
Loa Loa (eye worm) hypothetical protein 0.0046 0.0153 0.0376
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0452 0.1139
Brugia malayi MH2 domain containing protein 0.0236 0.1082 0.2754
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0046 0.0153 0.0012
Brugia malayi PHD-finger family protein 0.0019 0.0019 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0269 0.0671
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0283 0.0278
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0166 0.0742 0.2533
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0046 0.0153 0.0456
Trypanosoma brucei DNA polymerase eta, putative 0.0222 0.1014 0.3487
Echinococcus multilocularis peregrin 0.0062 0.023 0.0225
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.004 0.0123 0.0369
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0117 0.0501 0.0496
Brugia malayi Pre-SET motif family protein 0.0117 0.0501 0.1275
Brugia malayi hypothetical protein 0.0024 0.0047 0.0119
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0024 0.0046
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0452 0.1139
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0174 0.078 0.0775
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0153 0.0473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0158 0.0248
Brugia malayi MAP kinase sur-1 0.005 0.0174 0.0442
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0018
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0265 0.0863
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0132 0.0573 0.1447
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0018 0.0013
Brugia malayi AF-10 protein 0.0019 0.0019 0.0049
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0047 0.01
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0046 0.0153 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0117 0.0501 0.2037
Brugia malayi glutathione reductase 0.0502 0.2389 0.6079
Plasmodium falciparum thioredoxin reductase 0.0502 0.2389 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0174 0.078 0.3214
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0046
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0174 0.078 0.2471
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0145 0.014
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0204 0.0199
Trypanosoma cruzi DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0018 0.0013
Toxoplasma gondii selenide, water dikinase 0.0046 0.0153 0.057
Echinococcus granulosus intermediate filament protein 0.0027 0.0057 0.0052
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0172 0.0773 0.1349
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.002 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0145 0.014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0147 0.0646 0.082
Echinococcus granulosus tumor protein p63 0.0327 0.1534 0.1529
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0069 0.0214
Treponema pallidum thioredoxin reductase (trxB) 0.0046 0.0153 0.0153
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0024 0.0018
Trypanosoma brucei chrX additional, unordered contigs 0.0046 0.015 0.0463
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0153 0.0454
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0047 0.01
Trypanosoma cruzi NADH dehydrogenase, putative 0.0046 0.0153 0.0473
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0018 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0158 0.0162
Brugia malayi phosphofructokinase 0.0107 0.0452 0.1151
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0179 0.0286
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0452 0.0498
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0209 0.0807
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0269 0.0264
Leishmania major trypanothione reductase 0.0502 0.2389 0.8299
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0265 0.0863
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0565 0.2699 1
Echinococcus multilocularis tumor protein p63 0.0327 0.1534 0.1529
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0265 0.0438
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0018 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0601 0.2875 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1272 0.617 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0454 0.1528
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0069 0.0214
Loa Loa (eye worm) RGS-3 protein 0.0019 0.002 0.0037
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0164 0.0732 0.0726
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0145 0.014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1156 0.5601 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0174 0.0276
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0046 0.0153 0.0473
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0284 0.1322 0.4564
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0454 0.1528
Plasmodium falciparum glutathione reductase 0.0174 0.078 0.3214
Entamoeba histolytica disulphide oxidoreductase, putative 0.0046 0.0153 0.0239
Trichomonas vaginalis glutamate synthase, putative 0.0046 0.0153 0.0239
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0046 0.0153 0.0239
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0174 0.0545
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0153 0.057
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0046 0.0153 0.0473
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0046 0.0153 0.0148
Plasmodium vivax thioredoxin reductase, putative 0.0502 0.2389 1
Leishmania major DNA polymerase kappa, putative 0.0153 0.0678 0.231
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0452 0.0775
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0035
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0174 0.078 0.2667
Giardia lamblia Glutamate synthase 0.0046 0.0153 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0501 0.0496
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0047 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0018 0.0013
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0046 0.0153 0.0239
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0452 0.0694
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0018 0.0032
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0018 0.0013
Trichomonas vaginalis mercuric reductase, putative 0.0174 0.078 0.1362
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0069 0.0088
Echinococcus multilocularis jumonji domain containing protein 0.008 0.032 0.0315
Mycobacterium ulcerans DNA polymerase IV 0.0172 0.0773 0.2444
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0388 0.0748
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0145 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0388 0.1295
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0046
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0113 0.048 0.0475
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.002 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0069 0.0088
Leishmania major hypothetical protein, conserved 0.0046 0.0153 0.0473
Schistosoma mansoni kinase 0.0048 0.0162 0.0157
Brugia malayi hypothetical protein 0.0016 0.0004 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0501 0.0496
Brugia malayi MH1 domain containing protein 0.0016 0.0005 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0179 0.0286
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0265 0.0438
Trichomonas vaginalis glutathione reductase, putative 0.0174 0.078 0.1362
Schistosoma mansoni hypothetical protein 0.0504 0.24 0.2396
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0174 0.0545
Leishmania major hypothetical protein, conserved 0.0024 0.0047 0.01
Trypanosoma cruzi trypanothione reductase, putative 0.0174 0.078 0.2667
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0046 0.0153 0.057
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0269 0.0264
Schistosoma mansoni hypothetical protein 0.0058 0.0209 0.0204
Trichomonas vaginalis DNA polymerase eta, putative 0.0172 0.0773 0.1349
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0069 0.0214
Echinococcus multilocularis lamin 0.0027 0.0057 0.0052
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.004 0.0102
Echinococcus granulosus expressed protein 0.0132 0.0573 0.0568
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.015 0.0463
Toxoplasma gondii hypothetical protein 0.0097 0.0402 0.1621
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0046 0.0153 0.0148
Trypanosoma brucei DNA damage repair protein, putative 0.0046 0.015 0.0463
Treponema pallidum oxidoreductase 0.0046 0.0153 0.0153
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0153 0.0152
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1082 0.2744
Trypanosoma cruzi DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0174 0.0545
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0388 0.066
Brugia malayi 6-phosphofructokinase 0.0107 0.0452 0.1151
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0032
Treponema pallidum NADH oxidase 0.0174 0.078 0.1285
Echinococcus multilocularis glutamate synthase 0.0046 0.0153 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0573 0.0991
Trypanosoma brucei NADH dehydrogenase 0.0046 0.0153 0.0473
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1145 0.5543 0.8958
Leishmania major DNA polymerase eta, putative 0.012 0.0518 0.175
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0046 0.0153 0.039
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0123 0.0369
Plasmodium vivax SET domain protein, putative 0.0117 0.0501 0.2037
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0153 0.057
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0129 0.0558 0.189
Toxoplasma gondii NADPH-glutathione reductase 0.0174 0.078 0.3214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.004 0.0035
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0153 0.0239
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0153 0.0239
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0129 0.0558 0.0964
Toxoplasma gondii ImpB/MucB/SamB family protein 0.012 0.0518 0.2108
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0037
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0174 0.0168
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0069 0.0214
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1145 0.5543 0.8958
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0046 0.0153 0.0473
Entamoeba histolytica thioredoxin reductase, putative 0.0046 0.0153 0.0239
Entamoeba histolytica hypothetical protein 0.0046 0.0153 0.0239
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0046 0.0153 0.0473
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0158 0.0592
Leishmania major DNA polymerase eta, putative 0.0222 0.1014 0.3487
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0174 0.0429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0269 0.0264
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0786 0.0781
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1145 0.5543 0.8958
Schistosoma mansoni DNA polymerase eta 0.0222 0.1014 0.1009
Brugia malayi PHD-finger family protein 0.0058 0.0209 0.0533
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Onchocerca volvulus 0.0117 0.0501 0.1002
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0046 0.0153 0.0148
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0179 0.068
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0786 0.1999
Schistosoma mansoni hypothetical protein 0.0504 0.24 0.2396
Giardia lamblia NADH oxidase lateral transfer candidate 0.0174 0.078 0.1285
Trypanosoma brucei unspecified product 0.0166 0.0742 0.2533
Trichomonas vaginalis rotamase, putative 0.0132 0.0573 0.0991
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0153 0.057
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0174 0.078 0.3214
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0388 0.0975
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0209 0.0807
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0018 0.0013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0128 0.0553 0.1409
Giardia lamblia DINP protein human, muc B family 0.0153 0.0678 0.1101
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0209 0.052
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0129 0.0558 0.189
Loa Loa (eye worm) hypothetical protein 0.0099 0.0411 0.1034
Trypanosoma brucei unspecified product 0.0101 0.0423 0.1418
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0179 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0019 0.0005
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0204 0.0652
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0047 0.0121
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.002 0.0014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0174 0.078 0.0775
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0014
Brugia malayi polk-prov protein 0.0071 0.0277 0.0704
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0132 0.0573 0.1459
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0786 0.0781
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0046 0.0153 0.0153
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.002 0.0037
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0046 0.0153 0.0456
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0153 0.0239
Trypanosoma brucei unspecified product 0.0101 0.0423 0.1418
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0046 0.0153 0.0148
Schistosoma mansoni intermediate filament proteins 0.0027 0.0057 0.0052
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0046 0.0153 0.057
Brugia malayi jmjC domain containing protein 0.0189 0.0853 0.217
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1272 0.617 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0084 0.0341 0.1132
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0024 0.006
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0057 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1156 0.5601 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0069 0.0214
Plasmodium vivax DNA repair protein REV1, putative 0.0046 0.015 0.0557
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0047 0.01
Schistosoma mansoni terminal deoxycytidyl transferase 0.0147 0.0646 0.0641
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.002 0.0014
Trypanosoma brucei trypanothione reductase 0.0502 0.2389 0.8299
Trypanosoma cruzi DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Mycobacterium tuberculosis Conserved hypothetical protein 0.0316 0.1479 0.2205
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0052 0.0182 0.069
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0069 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0153 0.0678 0.231
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0057 0.0146
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0046 0.0153 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0069 0.0088
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0147 0.0646 0.0641
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0153 0.1186
Trypanosoma cruzi DNA damage repair protein, putative 0.0046 0.015 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Mycobacterium tuberculosis Probable oxidoreductase 0.1272 0.617 1
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0018 0.0013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1272 0.617 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0452 0.0775
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0046 0.0153 0.039
Plasmodium falciparum ferrodoxin reductase-like protein 0.0046 0.0153 0.057
Leishmania major mitochondrial DNA polymerase beta 0.0601 0.2875 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0046 0.0153 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0145 0.014
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0046 0.0153 0.0473
Echinococcus granulosus expressed protein 0.037 0.1741 0.1736
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0174 0.0276
Mycobacterium ulcerans glutamate synthase subunit beta 0.0046 0.0153 0.0012
Trypanosoma cruzi DNA damage repair protein, putative 0.0046 0.015 0.0463
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0019 0.0005
Schistosoma mansoni axis inhibition protein axin 0.0019 0.002 0.0014
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0046 0.0153 0.0148
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0046 0.0153 0.0012
Echinococcus multilocularis expressed protein 0.037 0.1741 0.1736
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.004 0.0123 0.0444
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0209 0.0204
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0174 0.078 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0046 0.0153 0.057
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1082 0.2744
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1145 0.5543 0.8958
Entamoeba histolytica hypothetical protein 0.0069 0.0265 0.0438
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0174 0.078 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0014
Schistosoma mansoni rotamase 0.0132 0.0573 0.0568
Mycobacterium tuberculosis Probable dehydrogenase 0.1145 0.5543 0.8958
Giardia lamblia Thioredoxin reductase 0.0046 0.0153 0.0153
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0018 0.0032
Onchocerca volvulus 0.0048 0.0162 0.0237
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0132
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0046 0.0153 0.057
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0204 0.0085
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0018 0.0013
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0123 0.0369
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0452 0.1521
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0069 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0047 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Echinococcus granulosus dna polymerase eta 0.0222 0.1014 0.1009
Onchocerca volvulus 0.0929 0.4483 1
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0046
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0265 0.0863
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0265 0.104
Brugia malayi PXA domain containing protein 0.0019 0.002 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0014
Echinococcus multilocularis L aminoadipate semialdehyde 0.0164 0.0732 0.0726
Echinococcus multilocularis lamin dm0 0.0027 0.0057 0.0052
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0153 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0069 0.0214
Echinococcus granulosus jumonji domain containing protein 0.008 0.032 0.0315
Brugia malayi Pre-SET motif family protein 0.0816 0.393 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0018 0.0013
Loa Loa (eye worm) glutathione reductase 0.0502 0.2389 0.6074
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0046 0.0153 0.0239
Brugia malayi hypothetical protein 0.0019 0.002 0.0051
Plasmodium falciparum DNA repair protein REV1, putative 0.0046 0.015 0.0557
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.002 0.0014
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0153 0.057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0117 0.0501 0.0496
Leishmania major DNA damage repair protein, putative 0.0046 0.015 0.0463
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0174 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0452 0.0775
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0153 0.0473
Echinococcus granulosus glutamate synthase 0.0046 0.0153 0.0148
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0174 0.078 0.2667
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0452 0.0775
Giardia lamblia DNA damage repair protein 0.0046 0.015 0.0147
Schistosoma mansoni jumonji domain containing protein 0.015 0.0662 0.0657
Brugia malayi beta-NAC-like protein 0.0069 0.0265 0.0673
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.0341 0.1132
Brugia malayi Thioredoxin reductase 0.0502 0.2389 0.6079
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0046 0.0153 0.0239
Schistosoma mansoni microtubule-associated protein tau 0.2053 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0222 0.1014 0.2581
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.002 0.0014
Trypanosoma brucei DNA damage repair protein, putative 0.0046 0.015 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0153 0.0473
Schistosoma mansoni sulfide quinone reductase 0.0046 0.0153 0.0148
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0129 0.0558 0.189
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0452 0.1521
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0046 0.0153 0.0239
Treponema pallidum fructose-bisphosphate aldolase 0.1156 0.5601 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0432 0.1449
Leishmania major hypothetical protein, conserved 0.0046 0.0153 0.0473
Plasmodium falciparum phd finger protein, putative 0.0058 0.0209 0.0807
Schistosoma mansoni lamin 0.0027 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0071 0.0277 0.0691
Leishmania major NADH dehydrogenase, putative 0.0046 0.0153 0.0473
Plasmodium falciparum thioredoxin reductase 0.0174 0.078 0.3214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Plasmodium vivax glutathione reductase, putative 0.0502 0.2389 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0084 0.0341 0.1132
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0046 0.0153 0.0148
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0069 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.002 0.0014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0174 0.078 0.1985
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0174 0.078 0.1042
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0174 0.0168
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0046 0.0153 0.0148
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0174 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0037
Echinococcus granulosus peregrin 0.0062 0.023 0.0225
Echinococcus granulosus lamin dm0 0.0027 0.0057 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0018
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0018 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0057 0.0132
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0126
Echinococcus granulosus lamin 0.0027 0.0057 0.0052
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0452 0.1186
Echinococcus multilocularis transcription factor btf3 0.0069 0.0265 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0108 0.0454 0.1528
Echinococcus granulosus phd:f box containing protein 0.0019 0.0018 0.0013
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0014
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0046 0.0153 0.0012
Loa Loa (eye worm) programmed cell death 8 0.0046 0.0153 0.0376
Echinococcus granulosus transcription factor btf3 0.0069 0.0265 0.0259
Schistosoma mansoni transcription factor btf3 0.0069 0.0265 0.0259
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0153 0.0239
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0046 0.0153 0.0376
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0174 0.0168
Trypanosoma brucei DNA polymerase IV, putative 0.0172 0.0773 0.2643
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0174 0.078 0.2471
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0174 0.078 0.3214
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0601 0.2875 1
Schistosoma mansoni sulfide quinone reductase 0.0046 0.0153 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0174 0.0168
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0018 0.0013
Echinococcus multilocularis geminin 0.0504 0.24 0.2396
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.002 0.0014
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0452 0.0447
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0145 0.0357
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0145 0.037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0153 0.0239
Mycobacterium ulcerans monoxygenase 0.0046 0.0153 0.0012
Brugia malayi hypothetical protein 0.0019 0.002 0.0051
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0284 0.1322 0.4564
Onchocerca volvulus 0.0046 0.0153 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0037
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0004
Brugia malayi intermediate filament protein 0.0027 0.0057 0.0146
Mycobacterium ulcerans NADH dehydrogenase 0.0046 0.0153 0.0012
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.002 0.0014
Echinococcus multilocularis microtubule associated protein 2 0.2053 1 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0046 0.0153 0.0473
Loa Loa (eye worm) hypothetical protein 0.0222 0.1014 0.257
Trypanosoma cruzi DNA polymerase eta, putative 0.012 0.0518 0.175
Schistosoma mansoni hypothetical protein 0.0046 0.0153 0.0148
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0153 0.0239
Toxoplasma gondii thioredoxin reductase 0.0502 0.2389 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.002 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0019 0.002 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0174 0.078 0.2667
Leishmania major basic transcription factor 3a, putative 0.0069 0.0265 0.0863
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0388 0.1295
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.002 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0153 0.0473
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1145 0.5543 0.8958
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0046 0.0153 0.0239
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0761 0.0756
Mycobacterium ulcerans ferredoxin reductase 0.0046 0.0153 0.0012
Brugia malayi 6-phosphofructokinase 0.0107 0.0452 0.1151
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0204 0.0199
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.015 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.0773 0.2643
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0019 0.0005
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0452 0.0447
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0265 0.066
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0388 0.066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0145 0.014
Loa Loa (eye worm) hypothetical protein 0.0117 0.0501 0.1262
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0452 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0277 0.0905
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis set domain proteins, putative 0.0928 0.4483 0.7996
Brugia malayi MH2 domain containing protein 0.0016 0.0005 0.0014
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0186 0.0459
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0069 0.0088
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0147 0.0646 0.0641
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0388 0.0383
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0153 0.0012
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0046 0.0153 0.0239
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0174 0.078 0.2667
Schistosoma mansoni lamin 0.0027 0.0057 0.0052
Trichomonas vaginalis rotamase, putative 0.0129 0.0558 0.0964
Echinococcus granulosus geminin 0.0504 0.24 0.2396
Trypanosoma cruzi DNA polymerase eta, putative 0.0222 0.1014 0.3487
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0204 0.0199
Loa Loa (eye worm) hypothetical protein 0.0164 0.0732 0.185
Mycobacterium ulcerans hypothetical protein 0.0316 0.1479 0.5216
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0388 0.1295
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0452 0.0447
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0153 0.0473
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0174 0.078 0.2667
Giardia lamblia Fructose-bisphosphate aldolase 0.1156 0.5601 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1156 0.5601 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0174 0.078 0.0775
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0189 0.0853 0.0848
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.002 0.0014
Echinococcus multilocularis expressed protein 0.0132 0.0573 0.0568
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0174 0.078 0.2667
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.002 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0505 0.2403 0.2399
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0452 0.0775
Onchocerca volvulus Alhambra homolog 0.0058 0.0209 0.0344
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0388 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0145 0.014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0128 0.0553 0.1409
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0265 0.104
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0174 0.078 0.2471
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0565 0.2699 0.4231
Echinococcus granulosus dna polymerase kappa 0.0172 0.0773 0.0768
Mycobacterium ulcerans dehydrogenase 0.0046 0.0153 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0174 0.0276

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2617 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.