Detailed information for compound 1565976

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 363.411 | Formula: C15H13N3O4S2
  • H donors: 2 H acceptors: 3 LogP: 2.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/2\S/C(=N\c3nccs3)/NC2=O)cc(c1O)OC
  • InChi: 1S/C15H13N3O4S2/c1-21-9-5-8(6-10(22-2)12(9)19)7-11-13(20)17-15(24-11)18-14-16-3-4-23-14/h3-7,19H,1-2H3,(H,16,17,18,20)/b11-7-
  • InChiKey: WZTAMSUHWXJZEV-XFFZJAGNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0588 0.0588
Schistosoma mansoni alpha tubulin 0.1183 0.7461 0.7461
Echinococcus granulosus peregrin 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.048 0.2985 0.2985
Trichomonas vaginalis tubulin beta chain, putative 0.1183 0.7461 0.7461
Echinococcus multilocularis Tubulin beta 2C chain 0.1582 1 1
Plasmodium falciparum bromodomain protein 1 0.0011 0.0001 0.0000000081606
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) tubulin alpha-2 chain 0.1183 0.7461 0.7461
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0588 0.0588
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0022 0.0022
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0588 0.0588
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Entamoeba histolytica tubulin alpha chain, putative 0.1183 0.7461 0.7461
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0126 0.0126
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin, putative 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trypanosoma cruzi alpha tubulin, putative 0.1183 0.7461 0.7461
Trichomonas vaginalis hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0131 0.0766 0.0765
Leishmania major beta tubulin 0.1582 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.1582 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum alpha tubulin 2 0.1183 0.7461 0.7461
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Giardia lamblia Delta tubulin 0.0406 0.2514 0.2514
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Schistosoma mansoni hypothetical protein 0.0068 0.0364 0.0364
Entamoeba histolytica ankyrin repeat protein, putative 0.0011 0.0001 0.0000000081606
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0011 0.0001 0.0001
Loa Loa (eye worm) alpha-tubulin 0.1183 0.7461 0.7461
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0126
Mycobacterium leprae cell division protein FtsZ 0.0406 0.2514 0.5
Echinococcus multilocularis tubulin alpha chain 0.1183 0.7461 0.7461
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0182 0.0182
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0361 0.0361
Echinococcus multilocularis PH interacting protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0162 0.0162
Echinococcus multilocularis Tubulin beta 2C chain 0.1582 1 1
Brugia malayi Tubulin beta chain 0.0406 0.2514 0.2514
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0588 0.0588
Brugia malayi Pre-SET motif family protein 0.0031 0.0126 0.0126
Loa Loa (eye worm) tubulin beta-2A chain 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi tubulin alpha-2 chain 0.1183 0.7461 0.7461
Echinococcus multilocularis tubulin subunit TubB 0.1183 0.7461 0.7461
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin, putative 0.048 0.2985 0.2985
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0364 0.0364
Entamoeba histolytica tubulin family protein 0.1582 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.1183 0.7461 0.7461
Echinococcus granulosus beta tubulin 0.1582 1 1
Echinococcus granulosus zinc finger protein 0.0011 0.0001 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0131 0.0766 0.0766
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin subunit beta 0.1582 1 1
Echinococcus multilocularis tubulin alpha chain 0.1183 0.7461 0.7461
Trypanosoma cruzi tubulin delta chain 0.0908 0.571 0.571
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0011 0.0001 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0588 0.0588
Echinococcus granulosus tubulin alpha 1C chain 0.1183 0.7461 0.7461
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum tubulin beta chain 0.1582 1 1
Schistosoma mansoni tubulin subunit alpha 0.1183 0.7461 0.7461
Trypanosoma brucei tubulin gamma chain 0.0967 0.6085 0.6085
Brugia malayi Muscleblind-like protein 0.0444 0.2759 0.2759
Echinococcus granulosus polybromo 1 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0364 0.0364
Schistosoma mansoni hypothetical protein 0.0031 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus Bromodomain containing protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0131 0.0131
Schistosoma mansoni tubulin subunit beta 0.0406 0.2514 0.2514
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) BRM protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0131 0.0131
Trypanosoma cruzi beta tubulin, putative 0.1582 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.012 0.0696 0.0696
Echinococcus multilocularis hypothetical protein 0.1183 0.7461 0.7461
Schistosoma mansoni transient receptor potential channel 0.0101 0.0573 0.0573
Echinococcus multilocularis protein kinase C binding protein 1 0.0011 0.0001 0.0001
Loa Loa (eye worm) tubulin beta chain 0.1582 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.1183 0.7461 0.7461
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0022 0.0022
Trypanosoma brucei epsilon tubulin 0.0885 0.5568 0.5567
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 1 0.0444 0.2759 0.2759
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus Tubulin beta 2C chain 0.1582 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0131 0.0131
Mycobacterium ulcerans cell division protein FtsZ 0.0406 0.2514 1
Echinococcus granulosus Tubulin beta 2C chain 0.1582 1 1
Trypanosoma brucei alpha tubulin, putative 0.048 0.2985 0.2984
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Loa Loa (eye worm) alpha-tubulin 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0703 0.4408 0.4408
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin gamma chain, putative 0.0965 0.6078 0.6078
Echinococcus granulosus tubulin alpha chain 0.1183 0.7461 0.7461
Echinococcus granulosus GPCR family 2 0.0031 0.0131 0.0131
Echinococcus granulosus tubulin delta chain 0.0406 0.2514 0.2514
Schistosoma mansoni tubulin subunit beta 0.1582 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0194 0.0194
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0364 0.0364
Loa Loa (eye worm) tubulin alpha 2 0.0777 0.4879 0.4879
Giardia lamblia Histone acetyltransferase GCN5 0.012 0.0696 0.0696
Echinococcus multilocularis beta tubulin 0.1582 1 1
Loa Loa (eye worm) acetyltransferase 0.0446 0.2769 0.2769
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Plasmodium vivax SET domain protein, putative 0.0031 0.0126 0.0125
Plasmodium vivax tubulin alpha chain, putative 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin epsilon chain, putative 0.0406 0.2514 0.2514
Plasmodium vivax tubulin epsilon chain, putative 0.0965 0.6078 0.6077
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) CYP4Cod1 0.0025 0.009 0.009
Trichomonas vaginalis tubulin alpha chain, putative 0.048 0.2985 0.2985
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.0444 0.2759 0.2759
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii alpha tubulin TUBA1 0.1183 0.7461 0.7461
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0131 0.0131
Echinococcus granulosus global transcription activator snf2l2 0.0011 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0564 0.0564
Echinococcus granulosus Tubulin alpha 1 chain 0.1183 0.7461 0.7461
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0216 0.0216
Trypanosoma cruzi epsilon tubulin, putative 0.0965 0.6078 0.6077
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0013 0.0011 0.0011
Loa Loa (eye worm) tubulin alpha 2 0.0777 0.4879 0.4879
Echinococcus multilocularis tubulin alpha 0.0885 0.5568 0.5568
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0588 0.0588
Trichomonas vaginalis tubulin gamma chain, putative 0.1582 1 1
Trypanosoma brucei epsilon tubulin 0.0965 0.6078 0.6077
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0364 0.0364
Trypanosoma brucei beta tubulin 0.0885 0.5568 0.5567
Plasmodium falciparum tubulin epsilon chain, putative 0.0965 0.6078 0.6077
Brugia malayi polybromodomain protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.009 0.009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0011 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0588 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0001 0.0000000081606
Brugia malayi Tubulin alpha chain 0.0406 0.2514 0.2514
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin alpha 0.0885 0.5568 0.5568
Loa Loa (eye worm) hypothetical protein 0.1183 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi zeta tubulin, putative 0.1245 0.7857 0.7857
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi alpha-tubulin 0.1183 0.7461 0.7461
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0119 0.0119
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0588 0.0588
Trichomonas vaginalis bromodomain containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi epsilon tubulin, putative 0.0965 0.6078 0.6077
Echinococcus granulosus tubulin alpha chain 0.1183 0.7461 0.7461
Schistosoma mansoni tubulin subunit beta 0.1582 1 1
Trichomonas vaginalis bromodomain containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0011 0.0001 0.0001
Trypanosoma cruzi tubulin gamma chain 0.0967 0.6085 0.6085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei beta tubulin 0.1582 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0967 0.6085 0.6085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin gamma 1 chain 0.0967 0.6085 0.6085
Echinococcus granulosus tubulin beta 4A class IVa 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis tubulin subunit beta 0.1582 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.1183 0.7461 0.7461
Plasmodium vivax tubulin alpha chain, putative 0.1183 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1451 0.1451
Onchocerca volvulus 0.048 0.2985 1
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0588 0.0588
Schistosoma mansoni bromodomain containing 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Schistosoma mansoni bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.1183 0.7461 0.7461
Schistosoma mansoni tubulin subunit beta 0.1582 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0885 0.5568 0.5567
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0573 0.0573
Brugia malayi Transient-receptor-potential like protein 0.0039 0.018 0.018
Echinococcus granulosus Tubulin beta 2C chain 0.1582 1 1
Brugia malayi bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni polybromo-1 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin, putative 0.0487 0.3032 0.3032
Plasmodium falciparum tubulin gamma chain 0.0967 0.6085 0.6085
Giardia lamblia Gamma tubulin 0.0967 0.6085 0.6085
Echinococcus granulosus Tubulin alpha 1 chain 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin epsilon chain, putative 0.1582 1 1
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Schistosoma mansoni tubulin subunit beta 0.1582 1 1
Entamoeba histolytica tubulin gamma chain 0.0967 0.6085 0.6085
Echinococcus granulosus histone acetyltransferase KAT2B 0.0433 0.269 0.269
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1477 0.1477
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis tubulin alpha 3 chain 0.1183 0.7461 0.7461
Toxoplasma gondii tubulin, putative 0.008 0.0441 0.044
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0777 0.4879 0.4879
Trichomonas vaginalis tubulin epsilon chain, putative 0.1582 1 1
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0011 0.0001 0.0001
Brugia malayi Cell division protein ftsZ 0.0406 0.2514 0.2514
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Echinococcus multilocularis polybromo 1 0.0011 0.0001 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0156 0.0156
Loa Loa (eye worm) beta-tubulin 0.1582 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.048 0.2985 0.2985
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0588 0.0588
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0364 0.0364
Trichomonas vaginalis bromodomain containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi BRM protein 0.0011 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0025 0.009 0.009
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0131 0.0766 0.0765
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0588 0.0588
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0536 0.0536
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis tubulin alpha 1C chain 0.1183 0.7461 0.7461
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0588 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum histone acetyltransferase GCN5 0.012 0.0696 0.0696
Entamoeba histolytica tubulin family protein 0.1582 1 1
Schistosoma mansoni tubulin subunit gamma 0.0967 0.6085 0.6085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0143
Echinococcus granulosus tubulin alpha 3 chain 0.1183 0.7461 0.7461
Trypanosoma brucei zeta tubulin 0.1245 0.7857 0.7857
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0131 0.0766 0.0765
Schistosoma mansoni transcription initiation factor tfiid 0.0011 0.0001 0.0001
Echinococcus multilocularis peroxisome assembly protein 26 0.1183 0.7461 0.7461
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Plasmodium falciparum tubulin delta chain, putative 0.0406 0.2514 0.2514
Echinococcus multilocularis Tubulin alpha 1 chain 0.1183 0.7461 0.7461
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0022 0.0022
Onchocerca volvulus 0.0243 0.1477 0.4947
Mycobacterium tuberculosis Cell division protein FtsZ 0.0406 0.2514 0.5
Trichomonas vaginalis lymphoid specific helicase, putative 0.0011 0.0001 0.0001
Brugia malayi tubulin alpha chain - mouse 0.1183 0.7461 0.7461
Echinococcus multilocularis GPCR, family 2 0.0031 0.0131 0.0131
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0011 0.0001 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0011 0.0001 0.0001
Trypanosoma cruzi zeta tubulin, putative 0.1245 0.7857 0.7857
Echinococcus multilocularis peregrin 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0446 0.2769 0.2769
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0364 0.0364
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0022 0.0022
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0194 0.0194
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni phd finger protein 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus alpha tubulin 0.1183 0.7461 0.7461
Toxoplasma gondii beta-1 tubulin, putative 0.1582 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0885 0.5568 0.5568
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.018 0.018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis tubulin epsilon chain 0.0965 0.6078 0.6078
Leishmania major beta tubulin 0.1582 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin epsilon chain, putative 0.1183 0.7461 0.7461
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.018 0.018
Loa Loa (eye worm) tubulin alpha-3 chain 0.0703 0.4408 0.4408
Echinococcus granulosus Tubulin beta 2C chain 0.1582 1 1
Brugia malayi Tubulin alpha chain 0.1183 0.7461 0.7461
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0131 0.0131
Schistosoma mansoni bromodomain containing protein 0.0011 0.0001 0.0001
Echinococcus granulosus CREB binding protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0156 0.0156
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Echinococcus multilocularis zinc finger protein 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin beta 1 chain 0.1582 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2514 0.2514
Leishmania major zeta tubulin, putative 0.1245 0.7857 0.7857
Brugia malayi polybromodomain protein 0.0011 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0131 0.0131
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0588 0.0588
Echinococcus granulosus bromodomain containing 2 0.0011 0.0001 0.0001
Loa Loa (eye worm) CBP-B 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0099 0.0564 0.0564
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis tubulin delta chain 0.0406 0.2514 0.2514
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0703 0.4408 0.4408
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0588 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0157 0.0157
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Plasmodium falciparum alpha tubulin 1 0.1183 0.7461 0.7461
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni tubulin subunit alpha 0.1183 0.7461 0.7461
Schistosoma mansoni hypothetical protein 0.0035 0.0156 0.0156
Echinococcus granulosus Tubulin beta 2C chain 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0126 0.0126
Leishmania major beta tubulin 0.1582 1 1
Onchocerca volvulus 0.0031 0.0126 0.042
Loa Loa (eye worm) hypothetical protein 0.0444 0.2759 0.2759
Loa Loa (eye worm) tubulin beta chain 0.0406 0.2514 0.2514
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0564 0.0564
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0182 0.0182
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0194 0.0194
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0361 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) BEN-1 protein 0.1582 1 1
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Echinococcus granulosus tubulin alpha 3 chain 0.1183 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.0062 0.0324 0.0324
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0364 0.0364
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0126
Trichomonas vaginalis tubulin gamma chain, putative 0.0406 0.2514 0.2514
Schistosoma mansoni zinc finger protein 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1183 0.7461 0.7461
Echinococcus granulosus tubulin alpha chain 0.1183 0.7461 0.7461
Schistosoma mansoni transient receptor potential channel 0.0068 0.0361 0.0361
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.018 0.018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi ATPase, AAA family protein 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0131 0.0131
Trichomonas vaginalis bromodomain-containing protein, putative 0.0131 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei beta tubulin 0.1582 1 1
Loa Loa (eye worm) BEN-1 protein 0.1582 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0297 0.1825 0.1825
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0022
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0013 0.0011 0.0011
Trypanosoma brucei beta tubulin 0.1582 1 1
Loa Loa (eye worm) hypothetical protein 0.0444 0.2759 0.2759
Schistosoma mansoni helicase 0.0011 0.0001 0.0001
Schistosoma mansoni transient receptor potential channel 0.0068 0.0361 0.0361
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0588 0.0588
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis global transcription activator snf2l2 0.0011 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0126 0.0126
Echinococcus granulosus bromodomain containing protein 8 0.0011 0.0001 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0216 0.0216
Brugia malayi Pre-SET motif family protein 0.0213 0.1289 0.1289
Schistosoma mansoni tubulin subunit delta 0.0406 0.2514 0.2514
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2514 0.2514
Leishmania major beta tubulin 0.1582 1 1
Leishmania major beta tubulin 0.1582 1 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0364 0.0364
Schistosoma mansoni tubulin subunit alpha 0.0406 0.2514 0.2514
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0777 0.4879 0.4879
Echinococcus granulosus protein kinase C binding protein 1 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.048 0.2985 0.2985
Toxoplasma gondii bromodomain-containing protein 0.0011 0.0001 0.0000000081606
Trichomonas vaginalis bromodomain containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis bromodomain containing 2 0.0011 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0126 0.0125
Trypanosoma brucei protein kinase, putative 0.0103 0.0588 0.0588
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0131 0.0766 0.0766
Trypanosoma brucei tubulin delta chain 0.0908 0.571 0.571
Schistosoma mansoni alpha tubulin 0.1183 0.7461 0.7461
Brugia malayi Tubulin alpha-2 chain 0.1183 0.7461 0.7461
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0011 0.0001 0.0001
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0536 0.0536
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0588 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii alpha-tubulin I, putative 0.1183 0.7461 0.7461
Echinococcus granulosus tubulin alpha chain 0.1183 0.7461 0.7461
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0364 0.0364
Trypanosoma brucei alpha tubulin 0.1183 0.7461 0.7461
Echinococcus granulosus beta tubulin 0.1582 1 1
Echinococcus multilocularis 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Loa Loa (eye worm) tubulin alpha chain 0.1183 0.7461 0.7461
Echinococcus multilocularis tubulin alpha chain 0.1183 0.7461 0.7461
Echinococcus multilocularis tubulin gamma 1 chain 0.0967 0.6085 0.6085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei alpha tubulin 0.1183 0.7461 0.7461
Echinococcus multilocularis Tubulin alpha 1 chain 0.1183 0.7461 0.7461
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0486 0.3024 0.3023
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) tubulin beta-1 chain 0.1582 1 1
Schistosoma mansoni CREB-binding protein 2 0.0011 0.0001 0.0001
Schistosoma mansoni tubulin subunit alpha 0.1183 0.7461 0.7461
Echinococcus granulosus muscleblind protein 0.0444 0.2759 0.2759
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0012 0.0008 0.0007
Schistosoma mansoni tubulin subunit beta 0.1582 1 1
Echinococcus granulosus Bromodomain containing protein 0.0011 0.0001 0.0001
Giardia lamblia Beta tubulin 0.1582 1 1
Schistosoma mansoni bromodomain containing protein 0.0011 0.0001 0.0001
Echinococcus granulosus PH interacting protein 0.0011 0.0001 0.0001
Brugia malayi Tubulin alpha-2 chain 0.1183 0.7461 0.7461
Trypanosoma brucei beta tubulin 0.1582 1 1
Trypanosoma brucei alpha tubulin 0.1183 0.7461 0.7461
Brugia malayi Tubulin beta chain 0.048 0.2985 0.2985
Leishmania major beta tubulin 0.1582 1 1
Echinococcus multilocularis beta tubulin 0.1582 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0022 0.0022
Loa Loa (eye worm) tubulin gamma chain 0.0967 0.6085 0.6085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0031 0.0131 0.0131
Echinococcus multilocularis tubulin alpha 3 chain 0.1183 0.7461 0.7461
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1451 0.1451
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0588 0.0588
Trypanosoma brucei alpha tubulin 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin beta chain, putative 0.1183 0.7461 0.7461
Plasmodium vivax tubulin beta chain, putative 0.1582 1 1
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) tubulin alpha chain 0.1183 0.7461 0.7461
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.009 0.0089
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0364 0.0364
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.1582 1 1
Toxoplasma gondii beta tubulin 0.1582 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0908 0.571 0.571
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0126
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0446 0.2769 0.2769
Trypanosoma cruzi tubulin delta chain 0.0908 0.571 0.571
Loa Loa (eye worm) hypothetical protein 0.0068 0.0364 0.0364
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0131 0.0131
Echinococcus multilocularis Tubulin beta 2C chain 0.1582 1 1
Plasmodium vivax SET domain containing protein 0.0012 0.0008 0.0007
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0406 0.2514 0.2514
Brugia malayi Cytochrome P450 family protein 0.0025 0.009 0.009
Echinococcus multilocularis tubulin alpha chain 0.1183 0.7461 0.7461
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0126 0.0126
Leishmania major gamma-tubulin 0.0967 0.6085 0.6085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1289 0.1289
Trypanosoma brucei cytochrome P450, putative 0.0025 0.009 0.0089
Leishmania major beta tubulin 0.1582 1 1
Schistosoma mansoni alpha tubulin 0.1183 0.7461 0.7461
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.009 0.009
Schistosoma mansoni tubulin subunit epsilon 0.0965 0.6078 0.6078
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin, putative 0.048 0.2985 0.2985
Giardia lamblia Epsilon tubulin 0.0486 0.3024 0.3023
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Plasmodium vivax delta tubulin, putative 0.0406 0.2514 0.2514
Schistosoma mansoni hypothetical protein 0.0031 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei epsilon tubulin 0.0965 0.6078 0.6077
Echinococcus granulosus tubulin subunit TubB 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin alpha chain, putative 0.048 0.2985 0.2985
Trichomonas vaginalis bromodomain containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi beta-tubulin, identical 0.1582 1 1
Brugia malayi Tubulin gamma chain 0.0967 0.6085 0.6085
Echinococcus multilocularis tubulin alpha chain 0.1183 0.7461 0.7461
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0157 0.0157
Brugia malayi acetyltransferase, GNAT family protein 0.0446 0.2769 0.2769
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0361 0.0361
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin epsilon chain 0.0965 0.6078 0.6078
Echinococcus multilocularis Tubulin beta 2C chain 0.1582 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Echinococcus multilocularis Tubulin alpha 1 chain 0.1183 0.7461 0.7461
Trichomonas vaginalis tubulin alpha chain, putative 0.1582 1 1
Leishmania major beta tubulin 0.1582 1 1
Brugia malayi MAP kinase sur-1 0.0103 0.0588 0.0588
Leishmania major epsilon tubulin, putative 0.0965 0.6078 0.6077
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0573 0.0573
Echinococcus multilocularis tubulin beta 1 chain 0.1582 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.1183 0.7461 0.7461
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0361 0.0361
Echinococcus multilocularis CREB binding protein 0.0011 0.0001 0.0001
Brugia malayi TAZ zinc finger family protein 0.0011 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0588 0.0588
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0011 0.0001 0.0001
Echinococcus multilocularis Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei zeta tubulin, putative 0.1245 0.7857 0.7857
Trichomonas vaginalis tubulin beta chain, putative 0.1183 0.7461 0.7461
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0364 0.0364
Leishmania major cytochrome p450-like protein 0.0025 0.009 0.0089
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0001 0.0001
Giardia lamblia Beta tubulin 0.1582 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0194 0.0194
Echinococcus multilocularis tubulin alpha 1C chain 0.1183 0.7461 0.7461
Brugia malayi hypothetical protein 0.0035 0.0156 0.0156
Trichomonas vaginalis bromodomain containing protein, putative 0.0011 0.0001 0.0001
Leishmania major delta tubulin, putative 0.0908 0.571 0.571
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Giardia lamblia Alpha-tubulin 0.1183 0.7461 0.7461
Entamoeba histolytica hypothetical protein 0.0035 0.0156 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0101 0.0573 0.0573
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Leishmania major alpha tubulin 0.1183 0.7461 0.7461
Brugia malayi PHD-finger family protein 0.0011 0.0001 0.0001
Treponema pallidum cell division protein FtsZ 0.0406 0.2514 0.5
Giardia lamblia Alpha-tubulin 0.1183 0.7461 0.7461
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0011 0.0001 0.0001
Echinococcus granulosus tubulin alpha chain 0.1183 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.0777 0.4879 0.4879
Trichomonas vaginalis tubulin beta chain, putative 0.1183 0.7461 0.7461
Leishmania major beta tubulin 0.1582 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.1183 0.7461 0.7461
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Schistosoma mansoni tubulin subunit beta 0.1582 1 1
Echinococcus multilocularis bromodomain containing protein 8 0.0011 0.0001 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.009 0.0089
Echinococcus granulosus CREB binding protein 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0406 0.2514 0.5
Giardia lamblia Beta tubulin 0.1582 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0126 0.0126
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0011 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Plasmodium vivax tubulin gamma chain, putative 0.0967 0.6085 0.6085
Leishmania major beta tubulin 0.1582 1 1
Toxoplasma gondii beta-tubulin, putative 0.1582 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) tubulin beta-4 chain 0.1582 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 122.2 uM Inhibition of soybean LOX type 1 pre-incubated for 4 mins at 7x10'-7 w/v concentration assessed as inhibition of sodium linoleate to 13-hydroperoxylinoleic acid ChEMBL. 22119153
IC50 (binding) > 200 uM Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassay ChEMBL. 22119153
Inhibition (binding) = 0 % Competitive inhibition of human recombinant COX2 assessed as inhibition of PGF2a production at 200 uM by enzyme immunoassay ChEMBL. 23219856
Inhibition (binding) = 23 % Inhibition of ovine COX1 assessed as inhibition of PGF2a production by enzyme immunoassay ChEMBL. 23219856
Inhibition (functional) = 39 % Antiinflammatory activity in AKR mouse assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip measured after 3.5 hrs of carrageenan-challenge ChEMBL. 23219856
MBC (functional) = 33 10'-2 umol/ml Bactericidal activity against Escherichia coli ATCC 35210 after 72 hrs by serial subcultivation method ChEMBL. 23219856

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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