Detailed information for compound 156858

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.321 | Formula: C8H3F5N4O4S3
  • H donors: 2 H acceptors: 6 LogP: 0.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1c(F)c(F)c(c(c1S(=O)(=O)Nc1nnc(s1)S(=O)(=O)N)F)F
  • InChi: 1S/C8H3F5N4O4S3/c9-1-2(10)4(12)6(5(13)3(1)11)24(20,21)17-7-15-16-8(22-7)23(14,18)19/h(H,15,17)(H2,14,18,19)
  • InChiKey: SNVIUSFXXHRDCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Bos taurus Carbonic anhydrase IV Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 287 aa 26.8 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Leishmania braziliensis carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 25.6 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor Carbonic anhydrase IV   312 aa 268 aa 24.6 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 253 aa 26.9 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 265 aa 26.0 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative Carbonic anhydrase IV   312 aa 264 aa 25.4 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 264 aa 24.2 %
Leishmania infantum carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 26.7 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 322 aa 28.3 %
Onchocerca volvulus Carbonic anhydrase IV   312 aa 252 aa 23.4 %
Echinococcus granulosus carbonic anhydrase Carbonic anhydrase IV   312 aa 304 aa 29.6 %
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase IV   312 aa 259 aa 30.1 %
Loa Loa (eye worm) hypothetical protein Carbonic anhydrase IV   312 aa 268 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0181 0.6454
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.1147
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0278 0.2919
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0078 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0165 0.0165
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.003 0.0078 0.0078
Onchocerca volvulus 0.003 0.0078 0.0249
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0043 0.0453
Brugia malayi C1-like domain containing protein 0.0019 0.0004 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0043 0.0342
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0043 0.2655
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0562 0.8726
Echinococcus granulosus cysteine protease 0.0062 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0453 0.2789 0.2789
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0278 0.0997
Echinococcus granulosus cathepsin b 0.0453 0.2789 0.2789
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0078 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.0984 0.0984
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0083 0.0871
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0006 0.0006
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.1259 0.4514
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Onchocerca volvulus Matrilysin homolog 0.0035 0.0106 0.0339
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0089 0.0089
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0278 0.0278
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.003 0.0078 0.2747
Loa Loa (eye worm) hypothetical protein 0.0102 0.0535 0.0535
Echinococcus multilocularis geminin 0.0673 0.4202 0.4202
Loa Loa (eye worm) hypothetical protein 0.0035 0.0106 0.0106
Entamoeba histolytica hypothetical protein, conserved 0.0018 0 0.0002
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0278 0.0278
Schistosoma mansoni hypothetical protein 0.0101 0.0529 0.0529
Schistosoma mansoni cpg binding protein 0.0086 0.0436 0.0436
Echinococcus granulosus phd:f box containing protein 0.0019 0.0006 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.1063 0.1063
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0278 0.0997
Brugia malayi Cathepsin L-like cysteine proteinase 0.003 0.0078 0.0078
Plasmodium vivax JmjC domain containing protein 0.0019 0.0006 0.0113
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0286 0.1717 0.1717
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Onchocerca volvulus 0.0086 0.0436 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0387 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Brugia malayi Cathepsin L-like precursor 0.0062 0.0278 0.0278
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.0078 0.028
Plasmodium vivax vivapain-3 0.0062 0.0278 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0043 0.2655
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Loa Loa (eye worm) fibroinase 0.0062 0.0278 0.0278
Brugia malayi jmjC domain containing protein 0.0194 0.1129 0.1129
Echinococcus granulosus geminin 0.0673 0.4202 0.4202
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.0078 0.2747
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0007 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Schistosoma mansoni tyrosine kinase 0.0837 0.5254 0.5254
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0062 0.0278 0.5232
Mycobacterium tuberculosis Probable reductase 0.0106 0.0562 0.8807
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.0505 0.3125 0.3125
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0006 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Brugia malayi MH2 domain containing protein 0.0116 0.0627 0.0627
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0774 0.4855 0.4855
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.003 0.0078 0.0078
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0529 0.0529
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0031 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0006 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.1226 0.7758 0.7758
Trypanosoma brucei rac serine-threonine kinase, putative 0.0026 0.0048 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0165 0.0165
Brugia malayi Matrixin family protein 0.0035 0.0106 0.0106
Brugia malayi Cathepsin L-like precursor 0.0062 0.0278 0.0278
Echinococcus granulosus GPCR family 2 0.0032 0.0089 0.0089
Brugia malayi glutathione reductase 0.0046 0.0181 0.0181
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Echinococcus granulosus cpg binding protein 0.0093 0.0479 0.0479
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0006 0.0006
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.0078 0.2747
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0042 0.0155 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0673 0.4202 0.4202
Echinococcus multilocularis serine:threonine protein kinase 38 0.0026 0.0048 0.0048
Brugia malayi cathepsin B-like cysteine proteinase 0.0453 0.2789 0.2789
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.1129 0.1129
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0056 0.0056
Onchocerca volvulus Cathepsin L homolog 0.0062 0.0278 0.0885
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0089
Brugia malayi jmjC domain containing protein 0.0019 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0529 0.0529
Brugia malayi jmjC domain containing protein 0.0019 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Plasmodium falciparum serine repeat antigen 6 0.003 0.0078 0.1437
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0278 0.2919
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0562 0.8807
Loa Loa (eye worm) glutathione reductase 0.0046 0.0181 0.0181
Schistosoma mansoni tyrosine kinase 0.0837 0.5254 0.5254
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0627 0.0627
Leishmania major carbonic anhydrase-like protein 0.0214 0.1259 1
Schistosoma mansoni cathepsin s 0.0031 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0083 0.0297
Echinococcus granulosus NDR protein kinase 0.0026 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.1147
Loa Loa (eye worm) hypothetical protein 0.0069 0.0328 0.0328
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.0078 0.028
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0278 0.2919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Loa Loa (eye worm) hypothetical protein 0.0031 0.0083 0.0083
Onchocerca volvulus 0.0031 0.0083 0.0264
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.1259 0.4514
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0019 0.0004 0.0004
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0127 0.0696 0.0696
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0109 0.0109
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0263 0.9463
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0505 0.3125 0.3125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Schistosoma mansoni carbonic anhydrase 0.0101 0.0529 0.0529
Brugia malayi cahepsin L-like non-peptiedase homolog 0.003 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.003 0.0078 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0025 0.0045 0.0076
Onchocerca volvulus 0.0035 0.0106 0.0339
Plasmodium vivax vivapain-2 0.0062 0.0278 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0078 0.0145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Echinococcus granulosus cathepsin l1 0.003 0.0078 0.0078
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0161 0.0917 0.1874
Echinococcus multilocularis epidermal growth factor receptor 0.1576 1 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0006 0.002
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0078 0.0145
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0043 0.2655
Schistosoma mansoni hypothetical protein 0.0049 0.02 0.02
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0165 0.0165
Toxoplasma gondii cathepsin CPC1 0.003 0.0078 0.0823
Onchocerca volvulus 0.0049 0.02 0.0635
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0106 0.0106
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0637 1
Echinococcus multilocularis insulin receptor 0.0505 0.3125 0.3125
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0078 0.0145
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0278 0.0997
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0278 0.0278
Plasmodium vivax unspecified product 0.003 0.0078 0.2747
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0453 0.2789 0.2789
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0019 0.0004 0.0004
Entamoeba histolytica protein kinase, putative 0.0026 0.0048 0.0509
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.0078 0.0822
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Brugia malayi protein kinase C3,putative 0.0267 0.16 0.16
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0181 0.2802
Onchocerca volvulus Tyrosine kinase homolog 0.0161 0.0915 0.291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.1259 0.1259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0278 0.0997
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0562 0.8807
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0026 0.0048 0.0048
Plasmodium vivax unspecified product 0.0031 0.0083 0.2909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.029 0.029
Onchocerca volvulus Glucosylceramidase homolog 0.0508 0.3145 1
Leishmania major hypothetical protein, conserved 0.0019 0.0006 0.0045
Entamoeba histolytica cysteine protease, putative 0.003 0.0078 0.0822
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Brugia malayi Protein kinase domain containing protein 0.0505 0.3125 0.3125
Echinococcus granulosus raf serine:threonine protein kinase 0.0029 0.007 0.007
Echinococcus granulosus cathepsin b 0.0453 0.2789 0.2789
Loa Loa (eye worm) AGC/NDR protein kinase 0.0026 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0167 0.0953 0.0953
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Onchocerca volvulus 0.0062 0.0278 0.0885
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0019 0.0004 0.0004
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.1259 0.1259
Brugia malayi Protein kinase domain containing protein 0.0019 0.0004 0.0004
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0043
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0083 0.0083
Brugia malayi Cathepsin L-like precursor 0.0062 0.0278 0.0278
Echinococcus granulosus cathepsin l1 0.0062 0.0278 0.0278
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.1259 0.1259
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0078 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0083 0.0083
Echinococcus multilocularis cathepsin b 0.0453 0.2789 0.2789
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0109 0.0109
Echinococcus granulosus serine:threonine protein kinase N2 0.0026 0.0048 0.0048
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.1259 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.1129 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0048 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0043 0.2655
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.1147
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0043 0.0342
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.003 0.0078 0.028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.029 0.029
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0006 0.0006
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0529 0.0529
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0534 0.0534
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0026 0.0048 0.0509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0062 0.0278 0.0278
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Brugia malayi jmjC domain containing protein 0.0079 0.0387 0.0387
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0035 0.0106 0.0106
Plasmodium falciparum serine repeat antigen 7 0.003 0.0078 0.1437
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Brugia malayi cathepsin F-like cysteine proteinase 0.003 0.0078 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0774 0.4855 1
Entamoeba histolytica hypothetical protein 0.003 0.0078 0.0822
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0534 0.0534
Loa Loa (eye worm) TK/FAK protein kinase 0.0283 0.1698 0.1698
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0109 0.0109
Onchocerca volvulus Cathepsin F homolog 0.0062 0.0278 0.0885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0436 0.0436
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1205 0.1205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0453 0.2789 0.2789
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.003 0.0078 0.2747
Echinococcus multilocularis protein kinase c iota type 0.0293 0.1762 0.1762
Onchocerca volvulus Matrix metalloproteinase homolog 0.0077 0.0379 0.1204
Echinococcus multilocularis cysteine protease 0.0062 0.0278 0.0278
Giardia lamblia Cathepsin B precursor 0.0161 0.0917 1
Echinococcus multilocularis cathepsin L 0.003 0.0078 0.0078
Plasmodium vivax unspecified product 0.0062 0.0278 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0161 0.0917 0.3287
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Entamoeba histolytica cysteine proteinase 1, putative 0.0062 0.0278 0.2919
Entamoeba histolytica cysteine protease, putative 0.003 0.0078 0.0822
Echinococcus granulosus epidermal growth factor receptor 0.0848 0.5325 0.5325
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.003 0.0078 0.2747
Echinococcus multilocularis GPCR, family 2 0.0032 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0013
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0848 0.5325 0.5325
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0167 0.0953 1
Onchocerca volvulus 0.0062 0.0278 0.0885
Brugia malayi Pre-SET motif family protein 0.0206 0.1205 0.1205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0453 0.2789 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0109 0.0109
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0006 0.0006
Onchocerca volvulus 0.0018 0 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.003 0.0078 0.0145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0534 0.0534
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0043 0.0043
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.1259 0.1259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1386 0.2842
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0263 0.2766
Echinococcus multilocularis zinc finger protein 0.0024 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0062 0.0278 0.0997
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0006 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0278 0.2919
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.1259 0.1259
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.1259 0.1259
Brugia malayi PHD-finger family protein 0.0029 0.0071 0.0071
Schistosoma mansoni unc-13 (munc13) 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0048 0.0048
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0387 0.0387
Toxoplasma gondii hypothetical protein 0.0101 0.0529 0.5559
Brugia malayi Cathepsin L-like precursor 0.0062 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Trichomonas vaginalis glucosylceramidase, putative 0.0774 0.4855 1
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Plasmodium vivax SET domain protein, putative 0.0031 0.0083 0.2912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0453 0.2789 0.2789
Echinococcus multilocularis serine threonine protein kinase 0.0026 0.0048 0.0048
Giardia lamblia PHD finger protein 15 0.0059 0.0263 0.2207
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0078 0.0078
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.003 0.0078 0.2747
Schistosoma mansoni cathepsin B (C01 family) 0.003 0.0078 0.0078
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0161 0.0917 0.0917
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Entamoeba histolytica protein kinase, putative 0.0026 0.0048 0.0509
Brugia malayi Protein kinase domain containing protein 0.0026 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0047 0.0183 0.0183
Loa Loa (eye worm) cathepsin B 0.0161 0.0917 0.0917
Echinococcus granulosus protein kinase c iota type 0.0293 0.1762 0.1762
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0529 0.0529
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0328 0.0328
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.0078 0.0822
Mycobacterium ulcerans hypothetical protein 0.0025 0.0043 0.2655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0043 0.0638
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Trichomonas vaginalis glucosylceramidase, putative 0.0774 0.4855 1
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0078 0.0822
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0026 0.0048 0.0048
Schistosoma mansoni atypical protein kinase C 0.0311 0.1879 0.1879
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.003 0.0078 0.0145
Schistosoma mansoni tyrosine kinase 0.0848 0.5325 0.5325
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0278 0.2919
Plasmodium falciparum serine repeat antigen 8 0.003 0.0078 0.1437
Loa Loa (eye worm) hypothetical protein 0.0042 0.0155 0.0155
Plasmodium vivax vivapain-1 0.0062 0.0278 1
Giardia lamblia Cathepsin B precursor 0.0161 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0529 0.0529
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0278 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Brugia malayi Matrixin family protein 0.0084 0.0423 0.0423
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.0048 0.0048
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0027 0.0027
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0026 0.0048 0.0048
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0026 0.0048 0.0048
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0007 0.0057
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0061 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0774 0.4855 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0056 0.0056
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0006 0.0061
Trypanosoma brucei trypanothione reductase 0.0046 0.0181 0.1433
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0263 0.0263
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Echinococcus granulosus cathepsin L 0.003 0.0078 0.0078
Plasmodium falciparum serine repeat antigen 9 0.003 0.0078 0.1437
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0048 0.0048
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0195 0.0195
Echinococcus multilocularis peregrin 0.0062 0.0278 0.0278
Echinococcus granulosus cathepsin L 0.0062 0.0278 0.0278
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0026 0.0048 0.0048
Plasmodium falciparum thioredoxin reductase 0.0046 0.0181 0.3377
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0089 0.0089
Brugia malayi PHD-finger family protein 0.0026 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0278 0.2919
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.0165 0.0165
Loa Loa (eye worm) AGC/PKN protein kinase 0.0026 0.0048 0.0048
Plasmodium falciparum serine repeat antigen 4 0.003 0.0078 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Plasmodium falciparum serine repeat antigen 1 0.003 0.0078 0.1437
Brugia malayi Pre-SET motif family protein 0.0031 0.0083 0.0083
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0078 0.0078
Echinococcus granulosus cathepsin l cysteine peptidase 0.0062 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0181 0.0181
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0027 0.0027
Schistosoma mansoni cathepsin C 0.003 0.0078 0.0078
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0048 0.0048
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0161 0.0917 0.7281
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.0165 0.0165
Schistosoma mansoni cpg binding protein 0.0093 0.0479 0.0479
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0562 0.8807
Schistosoma mansoni protein kinase C mu 0.0019 0.0004 0.0004
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0263 0.2766
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0278 0.0278
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0167 0.0953 1
Echinococcus multilocularis 0.0487 0.301 0.301
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.003 0.0078 0.1437
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.0078 0.0078
Entamoeba histolytica cysteine protease, putative 0.003 0.0078 0.0822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Plasmodium falciparum serine repeat antigen 5 0.003 0.0078 0.1437
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0026 0.0048 0.0048
Leishmania major trypanothione reductase 0.0046 0.0181 0.1433
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0412 0.0412
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.003 0.0078 0.0078
Brugia malayi jmjC domain containing protein 0.0019 0.0006 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0637 1
Trypanosoma cruzi cysteine protease, putative 0.0062 0.0278 0.0997
Brugia malayi cathepsin L precursor 0.003 0.0078 0.0078
Schistosoma mansoni cathepsin S (C01 family) 0.003 0.0078 0.0078
Onchocerca volvulus 0.0062 0.0278 0.0885
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0041 0.1392
Plasmodium vivax vivapain-2 0.0062 0.0278 1
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Plasmodium falciparum carbonic anhydrase 0.0101 0.0529 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0029 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0043 0.0043
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.003 0.0078 0.2747
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0181 0.0647
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0043 0.2655
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.0505 0.3125 0.3125
Giardia lamblia Cathepsin B precursor 0.0161 0.0917 1
Schistosoma mansoni hypothetical protein 0.0673 0.4202 0.4202
Brugia malayi Hr1 repeat family protein 0.0026 0.0048 0.0048
Loa Loa (eye worm) cysteine protease 0.0062 0.0278 0.0278
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0873 0.0873
Brugia malayi Matrixin family protein 0.0035 0.0106 0.0106
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0007 0.0057
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.003 0.0078 0.2747
Echinococcus granulosus epidermal growth factor receptor 0.1576 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0059 0.0263 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.0774 0.4855 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0181 0.1896
Echinococcus granulosus cathepsin L cysteine proteinase 0.0062 0.0278 0.0278
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0171 0.0984 0.0984
Schistosoma mansoni tyrosine kinase 0.0848 0.5325 0.5325
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.003 0.0078 0.2747
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Brugia malayi p70 ribosomal S6 kinase beta 0.0026 0.0048 0.0048
Loa Loa (eye worm) TK/INSR protein kinase 0.0505 0.3125 0.3125
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0043 0.2655
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0637 1
Brugia malayi protein kinase C II. 0.0044 0.0165 0.0165
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0026 0.0048 0.0048
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0165 0.0165
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.019 0.019
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0049 0.0049
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0006 0.0006
Echinococcus multilocularis protein tyrosine kinase 0.028 0.1678 0.1678
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0101 0.0529 0.0529
Brugia malayi Matrixin family protein 0.0035 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0078 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.004 0.0139 0.0139
Toxoplasma gondii cathepsin CPC2 0.003 0.0078 0.0823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.003 0.0078 0.0145
Brugia malayi cathepsin F-like cysteine proteinase 0.0031 0.0083 0.0083
Echinococcus multilocularis cathepsin L cysteine protease 0.0062 0.0278 0.0278
Leishmania major cysteine peptidase A (CPA) 0.0062 0.0278 0.2209
Onchocerca volvulus Matrilysin homolog 0.0077 0.0379 0.1204
Schistosoma mansoni cpg binding protein 0.0093 0.0479 0.0479
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0263 0.0263
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0412 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.0101 0.0534 0.0534
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.003 0.0078 0.0078
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0529 0.0529
Echinococcus granulosus peregrin 0.0062 0.0278 0.0278
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.0078 0.0078
Brugia malayi fibroinase precursor 0.003 0.0078 0.0078
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0278 0.0278
Echinococcus multilocularis cysteine protease 0.0062 0.0278 0.0278
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0278 0.0997
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0089 0.0089
Echinococcus multilocularis cathepsin b 0.0453 0.2789 0.2789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.003 0.0078 0.1437
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0637 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0019 0.0004 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0027 0.0027
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0048 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0089 0.0089
Brugia malayi jmjC domain containing protein 0.0019 0.0006 0.0006
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0078 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0152 0.0152
Loa Loa (eye worm) ctsf protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0006 0.0006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0062 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Schistosoma mansoni serine/threonine kinase 0.0026 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.003 0.0078 0.0822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.0078 0.2747
Echinococcus granulosus zinc finger protein 0.0024 0.0038 0.0038
Brugia malayi CXXC zinc finger family protein 0.0086 0.0436 0.0436
Brugia malayi Cathepsin L-like precursor 0.0031 0.0083 0.0083
Plasmodium falciparum phd finger protein, putative 0.0059 0.0263 0.4951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.019 0.019
Brugia malayi Protein kinase domain containing protein 0.0026 0.0048 0.0048
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.003 0.0078 0.1437
Plasmodium vivax glutathione reductase, putative 0.0046 0.0181 0.6454
Trypanosoma cruzi cruzipain precursor, putative 0.0031 0.0083 0.0297
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0043 0.0453
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.0952 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0083 0.0414 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0006 0.0061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0278 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0062 0.0278 0.0278
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0006 0.0006
Mycobacterium leprae PROBABLE HYDROLASE 0.0042 0.0155 0.1885
Brugia malayi Protein kinase domain containing protein 0.0019 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0083 0.0083
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0062 0.0278 0.5232
Echinococcus granulosus carbonic anhydrase 0.0101 0.0529 0.0529
Brugia malayi AF-10 protein 0.0019 0.0007 0.0007
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0529 0.0529
Plasmodium falciparum serine repeat antigen 3 0.003 0.0078 0.1437
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Schistosoma mansoni tyrosine kinase 0.0837 0.5254 0.5254
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0078 0.0145
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.0078 0.2747
Onchocerca volvulus 0.0147 0.0829 0.2635
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Onchocerca volvulus 0.003 0.0078 0.0249
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0562 0.8807
Loa Loa (eye worm) matrix metalloproteinase 0.0035 0.0106 0.0106
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0181 0.0181
Plasmodium falciparum cysteine proteinase falcipain 3 0.0062 0.0278 0.5232
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0026 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Plasmodium falciparum glutathione reductase 0.0046 0.0181 0.3377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0078 0.0145
Onchocerca volvulus 0.0234 0.1386 0.4406
Entamoeba histolytica cysteine protease, putative 0.0062 0.0278 0.2919
Leishmania major cathepsin L-like protease 0.0062 0.0278 0.2209
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0505 0.3125 0.3125
Brugia malayi Cathepsin L-like precursor 0.0062 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.028 0.1678 0.1678
Toxoplasma gondii cathepsin B 0.0161 0.0917 0.9626
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.1259 0.1259
Trypanosoma brucei cysteine peptidase C (CPC) 0.0161 0.0917 0.7281
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0007 0.0077
Echinococcus granulosus insulin receptor 0.0505 0.3125 0.3125
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0043 0.2655
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0529 0.0529
Entamoeba histolytica protein kinase, putative 0.0026 0.0048 0.0509
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0774 0.4855 0.4855
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0048 0.0048
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0006 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.003 0.0078 0.0822
Echinococcus granulosus carbonic anhydrase 0.0101 0.0529 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.0535 0.3321 0.6835
Brugia malayi cathepsin L-like precursor 0.003 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0048 0.019 0.019
Onchocerca volvulus Cathepsin L homolog 0.0062 0.0278 0.0885
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Onchocerca volvulus 0.0062 0.0278 0.0885
Loa Loa (eye worm) TK/EGFR protein kinase 0.1576 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.003 0.0078 0.0823
Echinococcus granulosus protein kinase C gamma type 0.0026 0.0048 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0278 0.0997
Schistosoma mansoni tyrosine kinase 0.1576 1 1
Brugia malayi Hemopexin family protein 0.0049 0.02 0.02
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0049 0.0049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0003 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0083 0.0083
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0019 0.0004 0.0004
Loa Loa (eye worm) matrixin family protein 0.0077 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Onchocerca volvulus 0.0019 0.0004 0.0012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0106 0.0106
Entamoeba histolytica cysteine proteinase 2 0.0062 0.0278 0.2919
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0529 0.0529
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0101 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0062 0.0278 0.0557
Echinococcus multilocularis cpg binding protein 0.0093 0.0479 0.0479
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0061 0.0061
Brugia malayi Cathepsin L-like precursor 0.003 0.0078 0.0078
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0006 0.0059
Onchocerca volvulus Protein TFG homolog 0.0018 0 0.0001
Onchocerca volvulus Cathepsin L homolog 0.003 0.0078 0.0249
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0627 0.0627
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0278 0.0997
Echinococcus multilocularis cathepsin L 0.0062 0.0278 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0048 0.0083
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0181 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Plasmodium falciparum serine repeat antigen 2 0.003 0.0078 0.1437
Trichomonas vaginalis glucosylceramidase, putative 0.0508 0.3145 0.6472
Entamoeba histolytica cysteine protease, putative 0.003 0.0078 0.0822
Brugia malayi Bromodomain containing protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0387 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.0774 0.4855 1
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0069 0.0328 0.0328
Toxoplasma gondii cathepsin CPL 0.0062 0.0278 0.2922
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0127 0.0696 0.0696
Echinococcus multilocularis cathepsin L cysteine protease 0.0062 0.0278 0.0278
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0042 0.0155 0.2402
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0062 0.0278 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0078
Plasmodium falciparum cysteine proteinase falcipain 1 0.0062 0.0278 0.5232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0278 0.2209
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0669 0.0669
Brugia malayi Bromodomain containing protein 0.0038 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0069 0.0328 0.0328
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.1147
Brugia malayi Cathepsin L-like precursor 0.0062 0.0278 0.0278
Brugia malayi Protein kinase c protein 2 0.0019 0.0004 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0453 0.2789 0.2789
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0124
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0078 0.0078
Brugia malayi cathepsin L-like cysteine proteinase 0.003 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Mycobacterium ulcerans hydrolase 0.0042 0.0155 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Echinococcus granulosus protein tyrosine kinase 0.028 0.1678 0.1678
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0043 0.0638
Onchocerca volvulus 0.0025 0.0043 0.0137
Echinococcus multilocularis dnaJ subfamily B 0.1226 0.7758 0.7758
Brugia malayi Thioredoxin reductase 0.0046 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0278 0.0997
Schistosoma mansoni hypothetical protein 0.0059 0.0263 0.0263
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0043 0.0342
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0013 0.0013
Echinococcus granulosus carbonic anhydrase II 0.0214 0.1259 0.1259
Brugia malayi hypothetical protein 0.0035 0.0109 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0535 0.3321 0.6835
Schistosoma mansoni zinc finger protein 0.0024 0.0038 0.0038
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0089
Toxoplasma gondii AGC kinase 0.0026 0.0048 0.0509
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0043
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.003 0.0078 0.2747
Brugia malayi Protein kinase domain containing protein 0.0026 0.0048 0.0048
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0263 0.0263
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0529 0.0529
Onchocerca volvulus 0.0062 0.0278 0.0885
Echinococcus granulosus dnaJ subfamily B 0.1226 0.7758 0.7758
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0043 0.0453
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0263 0.0263
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0027 0.0027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0562 0.8807
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0062 0.0278 0.0557
Brugia malayi Protein kinase domain containing protein 0.0283 0.1698 0.1698
Brugia malayi Matrixin family protein 0.0035 0.0106 0.0106
Echinococcus granulosus carbonic anhydrase 0.0101 0.0529 0.0529
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.019 0.019
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0025 0.0041 0.0728
Onchocerca volvulus 0.0062 0.0278 0.0885
Schistosoma mansoni cathepsin F (C01 family) 0.0062 0.0278 0.0278
Schistosoma mansoni bromodomain containing protein 0.0067 0.0313 0.0313
Onchocerca volvulus 0.0062 0.0278 0.0885
Brugia malayi PHD-finger family protein 0.0059 0.0263 0.0263
Brugia malayi Bromodomain containing protein 0.0078 0.0386 0.0386
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0026 0.0048 0.0048
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0006 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0078 0.0145
Schistosoma mansoni hypothetical protein 0.0032 0.0089 0.0089
Echinococcus multilocularis epidermal growth factor receptor 0.0848 0.5325 0.5325
Loa Loa (eye worm) matrixin family protein 0.0084 0.0423 0.0423
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0026 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0278 0.0557
Onchocerca volvulus Alhambra homolog 0.0059 0.0263 0.0838

Activities

Activity type Activity value Assay description Source Reference
Delta IOP (functional) = 4.9 mmHg Tested for in vivo IOP-lowering of normotensive albino rabbits after topical administration at the specified interval (30 min) at pH 7.5 ChEMBL. 11087579
Delta IOP (functional) = 8.3 mmHg Tested for in vivo IOP-lowering of glaucomatous rabbits after topical administration at the specified interval( 30 min) at pH 7.5 ChEMBL. 11087579
Delta IOP (functional) = 10.2 mmHg Tested for in vivo IOP-lowering of normotensive albino rabbits after topical administration at the specified interval (90 min) at pH 7.5 ChEMBL. 11087579
Delta IOP (functional) = 12.5 mmHg Tested for in vivo IOP-lowering of normotensive albino rabbits after topical administration at the specified interval (60 min) at pH 7.5 ChEMBL. 11087579
Delta IOP (functional) = 15.7 mmHg Tested for in vivo IOP-lowering of glaucomatous rabbits after topical administration at the specified interval( 60 min) at pH 7.5 ChEMBL. 11087579
Delta IOP (functional) = 17.4 mmHg Tested for in vivo IOP-lowering of glaucomatous rabbits after topical administration at the specified interval( 90 min) at pH 7.5 ChEMBL. 11087579
Drug concentration (functional) = 12.5 uM Tested for ex vivo distribution in ciliary process after topical administration in albino rabbits (Ocular tissue concentration after 2 hr) ChEMBL. 11087579
Drug concentration (functional) = 42 uM Tested for ex vivo distribution in aqueous humor after topical administration in albino rabbits (Ocular tissue concentration after 2 hr) ChEMBL. 11087579
Drug concentration (functional) = 45 uM Tested for ex vivo distribution in ciliary process after topical administration in albino rabbits (Ocular tissue concentration after 1 hr) ChEMBL. 11087579
Drug concentration (functional) = 69 uM Tested for ex vivo distribution in cornea after topical administration in albino rabbits (Ocular tissue concentration after 2 hr) ChEMBL. 11087579
Drug concentration (functional) = 176 uM Tested for ex vivo distribution in cornea after topical administration in albino rabbits (Ocular tissue concentration after 1 hr) ChEMBL. 11087579
Drug concentration (functional) = 324 uM Tested for ex vivo distribution in aqueous humor after topical administration in albino rabbits (Ocular tissue concentration after 1 hr) ChEMBL. 11087579
IC50 (functional) > 50 uM Ex vivo inhibition of Plasmodium falciparum growth in cultured cells after 48hrs as [3H]hypoxanthine uptake ChEMBL. 18805693
Ki (binding) = 0.3 nM Inhibition of human recombinant carbonic anhydrase II (CA2) ChEMBL. 11087579
Ki (binding) = 0.3 nM Inhibition of human recombinant carbonic anhydrase II (CA2) ChEMBL. 11087579
Ki (binding) = 6 nM Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes ChEMBL. 11087579
Ki (binding) = 6 nM Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes ChEMBL. 11087579
Ki (binding) = 210 nM Inhibition of human recombinant carbonic anhydrase I (CA1) ChEMBL. 11087579
Ki (binding) = 210 nM Inhibition of human recombinant carbonic anhydrase I (CA1) ChEMBL. 11087579
Kin (functional) = 4500 hr-1 In vitro transcorneal accession rate in rabbit corneal intact epithelium ChEMBL. 11087579
Kin (functional) = 8700 hr-1 In vitro transcorneal accession rate in rabbit corneal denuded epithelium ChEMBL. 11087579
logD (ADMET) = 2.113 Partition coefficient (logD) (chloroform/buffer) ChEMBL. 11087579
Reactivity (functional) = 68 % Reactivity of the compound was determined against glutathione after 24 hours of incubation ChEMBL. 15139757
Reactivity (functional) = 76 % Reactivity of the compound was determined against cysteine after 24 hours of incubation ChEMBL. 15139757
Solubility = 62 mM Solubility of the compound in pH 7.4 Buffer, at 25 Degree C ChEMBL. 11087579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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